Phosphatidylinositol 3-kinase regulatory subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Membrane spanning 4-domains A2
type: Protein
cellular location: Cell Membrane
entity reference: Membrane spanning 4-domains A2

Compound/PW C013567 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mono- and diglycerides
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
name: SubPathwayInput

ChemicalStructure/PW C000693
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC=N1

Leukotriene E4
type: SmallMoleculeReference
xref: Reference/CAS 75715-89-8
xref: Reference/ChemSpider 4444402
xref: Reference/PubChem-compound 5280749
xref: Reference/HMDB HMDB0002200
xref: Reference/KEGG Compound C05952
xref: Reference/ChEBI CHEBI 15650
chemical formula: C23H37NO5S
molecular weight: 439.23926
structure: ChemicalStructure/PW C001485

ProteinComplex/11209 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

Reference/CAS 9005-49-6
type: UnificationXref
id: 9005-49-6
db: CAS

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Immunoglobulin E
type: Complex
component stoichiometry: Protein/19564 Extracellular Space/Stoichiometry/4.0
cellular location: Extracellular Space
component: Uncharacterized protein
name: SubPathwayActivation
name: SubPathwayActivator

Reference/BioCyc LEUKOTRIENE-C4
type: UnificationXref
id: LEUKOTRIENE-C4
db: BioCyc

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown
name: SubPathwayOutput

Interleukin-5
type: Complex
component stoichiometry: Protein/19646 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Interleukin-5
name: SubPathwayOutput

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayInput

Leukotriene D4
type: SmallMolecule
cellular location: Cytosol
entity reference: Leukotriene D4
name: SubPathwayOutput

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytosol
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Reference/HMDB HMDB0001198
type: UnificationXref
id: HMDB0001198
db: HMDB

Reaction174230
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11244 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19500 Cytosol/Stoichiometry/1.0
right: RAC-alpha serine/threonine-protein kinase
spontaneous: true
left: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
name: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial → RAC-alpha serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

Reaction174231
type: BiochemicalReaction
participant stoichiometry: Protein/19618 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11209 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19407 Cytosol/Stoichiometry/1.0
right: Dual specificity mitogen-activated protein kinase kinase 6
spontaneous: true
left: Ras-related C3 botulinum toxin substrate 1
name: Ras-related C3 botulinum toxin substrate 1 → Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 6 + Dual specificity mitogen-activated protein kinase kinase 7
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 4444133
type: UnificationXref
id: 4444133
db: ChemSpider

Reaction174232
type: BiochemicalReaction
participant stoichiometry: Protein/19458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19407 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 13
spontaneous: true
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 7 → Mitogen-activated protein kinase 8
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW000044
type: UnificationXref
id: PW000044
db: PathWhiz

Reaction174233
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11209 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19407 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 13
spontaneous: true
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 6 → Mitogen-activated protein kinase 14
conversion direction: LEFT_TO_RIGHT

Reaction174234
type: BiochemicalReaction
participant stoichiometry: Protein/19605 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19628 Cytosol/Stoichiometry/1.0
right: GRB2-related adapter protein
spontaneous: true
left: Linker for activation of T cells
name: Linker for activation of T-cells family member 1 → Growth factor receptor-bound protein 2
conversion direction: LEFT_TO_RIGHT

Reaction174235
type: BiochemicalReaction
participant stoichiometry: Protein/19628 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19396 Cytosol/Stoichiometry/1.0
right: Rap guanine nucleotide exchange factor 2
spontaneous: true
left: GRB2-related adapter protein
name: Growth factor receptor-bound protein 2 → Son of sevenless homolog 1
conversion direction: LEFT_TO_RIGHT

Reaction174237
type: BiochemicalReaction
participant stoichiometry: Protein/19430 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19396 Cytosol/Stoichiometry/1.0
right: Ras-related protein Rap-1b
spontaneous: true
left: Rap guanine nucleotide exchange factor 2
name: Son of sevenless homolog 1 → GTPase HRas + GTPase KRas + GTPase NRas
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1
name: SubPathwayInput

Reference/KEGG Compound C00696
type: UnificationXref
id: C00696
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/19587 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Activated CDC42 kinase 1
stoichiometric coefficient: 1.0

Rap guanine nucleotide exchange factor 2
type: ProteinReference
xref: Reference/UniProt F1MSG6
organism: Bos taurus

Protein/19570 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Membrane spanning 4-domains A2
stoichiometric coefficient: 1.0

Protein/19598 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte cytosolic protein 2
stoichiometric coefficient: 1.0

Protein/19500 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAC-alpha serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001403
type: UnificationXref
id: HMDB0001403
db: HMDB

Reaction174238
type: BiochemicalReaction
participant stoichiometry: Protein/19409 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19430 Cytosol/Stoichiometry/1.0
right: RAF proto-oncogene serine/threonine-protein kinase
spontaneous: true
left: Ras-related protein Rap-1b
name: GTPase HRas + GTPase KRas + GTPase NRas → RAF proto-oncogene serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

High affinity immunoglobulin epsilon receptor subunit gamma
type: Protein
cellular location: Cytosol
entity reference: High affinity immunoglobulin epsilon receptor subunit gamma

Reaction174239
type: BiochemicalReaction
participant stoichiometry: Protein/19409 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19407 Cytosol/Stoichiometry/1.0
right: Dual specificity mitogen-activated protein kinase kinase 6
spontaneous: true
left: RAF proto-oncogene serine/threonine-protein kinase
name: RAF proto-oncogene serine/threonine-protein kinase → Dual specificity mitogen-activated protein kinase kinase
conversion direction: LEFT_TO_RIGHT

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/ChemSpider 17216115
type: UnificationXref
id: 17216115
db: ChemSpider

Reference/UniProt A6QLK6
type: UnificationXref
id: A6QLK6
db: UniProt

ChemicalStructure/PW C001084
type: ChemicalStructure
structure format: SMILES

Protein/17373 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 3-kinase regulatory subunit alpha
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P04409
organism: Bos taurus

Reaction174220
type: BiochemicalReaction
participant stoichiometry: Protein/19575 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11228 Cytosol/Stoichiometry/1.0
right: Tyrosine-protein kinase Fyn
spontaneous: true
left: High affinity immunoglobulin epsilon receptor
left: Tyrosine-protein kinase Fyn
name: High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase Lyn → Tyrosine-protein kinase BTK + Tyrosine-protein kinase Fyn
conversion direction: LEFT_TO_RIGHT

Reaction174221
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11241 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19605 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19587 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19590 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19598 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19600 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19592 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11228 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol 3-kinase
right: Linker for activation of T cells
right: GRB2-associated-binding protein 1
right: Proto-oncogene vav
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
right: Lymphocyte cytosolic protein 2
spontaneous: true
left: High affinity immunoglobulin epsilon receptor
left: Activated CDC42 kinase 1
name: High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase SYK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + GRB2-associated-binding protein 2 + Guanine nucleotide exchange factor VAV3 + Linker for activation of T-cells family member 1 + Lymphocyte cytosolic protein 2 + Phosphatidylinositol 3-kinase
conversion direction: LEFT_TO_RIGHT

Leukotriene C4
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444133
xref: Reference/CAS 72025-60-6
xref: Reference/ChEBI CHEBI 16978
xref: Reference/BioCyc LEUKOTRIENE-C4
xref: Reference/PubChem-compound 5280493
xref: Reference/KEGG Compound C02166
xref: Reference/HMDB HMDB0001198
chemical formula: C30H47N3O9S
molecular weight: 625.3033
structure: ChemicalStructure/PW C000933

Reaction174222
type: BiochemicalReaction
participant stoichiometry: Protein/19575 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19592 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002108 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol-3,4,5-trisphosphate
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
spontaneous: true
left: Phosphatidylinositol-3,4,5-trisphosphate
left: Tyrosine-protein kinase Fyn
name: Phosphatidylinositol-3,4,5-trisphosphate + Tyrosine-protein kinase BTK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Phosphatidylinositol-3,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reaction174223
type: BiochemicalReaction
participant stoichiometry: Protein/19575 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19590 Cytosol/Stoichiometry/1.0
right: GRB2-associated-binding protein 1
spontaneous: true
left: Tyrosine-protein kinase Fyn
name: Tyrosine-protein kinase Fyn → GRB2-associated-binding protein 2
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P32871
type: UnificationXref
id: P32871
db: UniProt

Reaction174224
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11241 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19590 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol 3-kinase
spontaneous: true
left: GRB2-associated-binding protein 1
name: GRB2-associated-binding protein 2 → Phosphatidylinositol 3-kinase
conversion direction: LEFT_TO_RIGHT

Reaction174225
type: BiochemicalReaction
participant stoichiometry: Protein/19592 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C013567 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
right: Mono- and diglycerides
right: Inositol 1,4,5-trisphosphate
spontaneous: true
left: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 → Inositol 1,4,5-trisphosphate + Mono- and diglycerides
conversion direction: LEFT_TO_RIGHT

Reaction174226
type: BiochemicalReaction
participant stoichiometry: Protein/19608 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C013567 Cytosol/Stoichiometry/1.0
right: Protein kinase C alpha type
spontaneous: true
left: Mono- and diglycerides
name: Mono- and diglycerides → Protein kinase C alpha type
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5280493
type: UnificationXref
id: 5280493
db: PubChem-compound

Ras-related protein Rap-1b
type: Protein
cellular location: Cytosol
entity reference: Ras-related protein Rap-1b

ProteinComplex/11228 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor
stoichiometric coefficient: 1.0

Reference/BioCyc HEPARIN
type: UnificationXref
id: HEPARIN
db: BioCyc

Protein/19605 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Linker for activation of T cells
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004249
type: UnificationXref
id: HMDB0004249
db: HMDB

ChemicalStructure/PW C001775
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Protein/19572 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit gamma
stoichiometric coefficient: 2.0

Mono- and diglycerides
type: SmallMoleculeReference
xref: Reference/CAS 67254-73-3
xref: Reference/PubChem-compound 6850771
xref: Reference/ChemSpider 5254058
xref: Reference/HMDB HMDB0032436
chemical formula: C100H188O22
molecular weight: 1741.3593
structure: ChemicalStructure/PW C013567

Proto-oncogene vav
type: ProteinReference
xref: Reference/UniProt Q08DN7
organism: Bos taurus

Reaction174227
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11241 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11244 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19618 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19592 Cytosol/Stoichiometry/1.0
right: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
right: Ras-related C3 botulinum toxin substrate 1
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
spontaneous: true
left: Phosphatidylinositol 3-kinase
name: Phosphatidylinositol 3-kinase → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Ras-related C3 botulinum toxin substrate 1 + [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
conversion direction: LEFT_TO_RIGHT

Reaction174228
type: BiochemicalReaction
participant stoichiometry: Protein/19598 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19600 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19592 Cytosol/Stoichiometry/1.0
right: Proto-oncogene vav
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
spontaneous: true
left: Lymphocyte cytosolic protein 2
name: Lymphocyte cytosolic protein 2 → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Guanine nucleotide exchange factor VAV3
conversion direction: LEFT_TO_RIGHT

Reaction174229
type: BiochemicalReaction
participant stoichiometry: Protein/19618 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19600 Cytosol/Stoichiometry/1.0
right: Ras-related C3 botulinum toxin substrate 1
spontaneous: true
left: Proto-oncogene vav
name: Guanine nucleotide exchange factor VAV3 → Ras-related C3 botulinum toxin substrate 1
conversion direction: LEFT_TO_RIGHT

Linker for activation of T cells
type: ProteinReference
xref: Reference/UniProt F1MZ60
organism: Bos taurus

ChemicalStructure/PW C013567
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16978
type: UnificationXref
id: CHEBI:16978
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Low affinity immunoglobulin gamma Fc region receptor III
type: Protein
cellular location: Cell Membrane
entity reference: Low affinity immunoglobulin gamma Fc region receptor III

Tyrosine-protein kinase Fyn
type: Protein
cellular location: Cytosol
entity reference: Tyrosine-protein kinase Fyn

Protein/19615 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
stoichiometric coefficient: 2.0

Membrane spanning 4-domains A2
type: ProteinReference
xref: Reference/UniProt E1BNU1
organism: Bos taurus

High affinity immunoglobulin epsilon receptor subunit gamma
type: ProteinReference
xref: Reference/UniProt Q3SZX3
organism: Bos taurus

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: Reference/UniProt A0JNB0
organism: Bos taurus

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Protein/19570 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Membrane spanning 4-domains A2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 13
type: ProteinReference
xref: Reference/UniProt Q3T0N5
organism: Bos taurus

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reaction174241
type: BiochemicalReaction
participant stoichiometry: Protein/19413 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/7764 Cytosol/Stoichiometry/1.0
right: Unknown
spontaneous: true
left: Mitogen-activated protein kinase 1
name: Mitogen-activated protein kinase 1 → Cytosolic phospholipase A2
conversion direction: LEFT_TO_RIGHT

Reaction174242
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/7764 Cytosol/Stoichiometry/1.0
right: Arachidonic acid
spontaneous: true
left: Unknown
name: Cytosolic phospholipase A2 → Arachidonic acid
conversion direction: LEFT_TO_RIGHT

Granulocyte-macrophage colony-stimulating factor
type: Protein
cellular location: Cytosol
entity reference: Granulocyte-macrophage colony-stimulating factor
name: SubPathwayOutput

Reference/UniProt F1MGR6
type: UnificationXref
id: F1MGR6
db: UniProt

Reference/UniProt Q3T0N5
type: UnificationXref
id: Q3T0N5
db: UniProt

Leukotriene E4
type: SmallMolecule
cellular location: Cytosol
entity reference: Leukotriene E4
name: SubPathwayOutput

GRB2-associated-binding protein 1
type: ProteinReference
xref: Reference/UniProt A6QLU3
organism: Bos taurus

Reference/ChEBI CHEBI 15650
type: UnificationXref
id: CHEBI:15650
db: ChEBI

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reaction174240
type: BiochemicalReaction
participant stoichiometry: Protein/19413 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19407 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 1
spontaneous: true
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase → Mitogen-activated protein kinase 1
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000933
type: ChemicalStructure
structure format: SMILES

High affinity immunoglobulin epsilon receptor
type: Complex
component stoichiometry: Protein/19570 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19572 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/19567 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Low affinity immunoglobulin gamma Fc region receptor III
component: Membrane spanning 4-domains A2
component: High affinity immunoglobulin epsilon receptor subunit gamma

Reference/CAS 75715-89-8
type: UnificationXref
id: 75715-89-8
db: CAS

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Fc Epsilon Receptor I Signaling in Mast Cells
type: Pathway
pathway order: PathwayEnzymeReaction/2118027
pathway order: PathwayEnzymeReaction/2118026
pathway order: PathwayEnzymeReaction/2118029
pathway order: PathwayEnzymeReaction/2118028
pathway order: PathwayEnzymeReaction/2118023
pathway order: PathwayEnzymeReaction/2118022
pathway order: PathwayEnzymeReaction/2118025
pathway order: PathwayEnzymeReaction/2118024
pathway order: PathwayEnzymeReaction/2118040
pathway order: PathwayEnzymeReaction/2118021
pathway order: PathwayEnzymeReaction/2118020
pathway order: PathwaySubPathway/109211
pathway order: PathwayEnzymeReaction/2118019
pathway order: PathwaySubPathway/109210
pathway order: PathwaySubPathway/109213
pathway order: PathwaySubPathway/109212
pathway order: PathwayEnzymeReaction/2118038
pathway order: PathwayEnzymeReaction/2118037
pathway order: PathwayEnzymeReaction/2118039
pathway order: PathwaySubPathway/109215
pathway order: PathwaySubPathway/109214
pathway order: PathwaySubPathway/109217
pathway order: PathwaySubPathway/109216
pathway order: PathwayEnzymeReaction/2118034
pathway order: PathwayEnzymeReaction/2118033
pathway order: PathwayEnzymeReaction/2118036
pathway order: PathwayEnzymeReaction/2118035
pathway order: PathwayEnzymeReaction/2118030
pathway order: PathwayEnzymeReaction/2118032
pathway order: PathwayEnzymeReaction/2118031
pathway component: Reaction174230
pathway component: Reaction174231
pathway component: Reaction174232
pathway component: Reaction174233
pathway component: Reaction174234
pathway component: Reaction174235
pathway component: Reaction174237
pathway component: SubPathwayControl109210
pathway component: SubPathwayControl109211
pathway component: Arachidonic Acid Metabolism
pathway component: Reaction174238
pathway component: Reaction174239
pathway component: Reaction174241
pathway component: Reaction174220
pathway component: Reaction174242
pathway component: Reaction174221
pathway component: Reaction174222
pathway component: Reaction174223
pathway component: Reaction174224
pathway component: Reaction174225
pathway component: Reaction174226
pathway component: Phosphatidylinositol signaling system
pathway component: MAPK signaling pathway
pathway component: Generation of eicosanoids
pathway component: Degranulation
pathway component: Reaction174240
pathway component: Cytokine gene transcription
pathway component: Reaction174227
pathway component: Reaction174228
pathway component: Reaction174229
xref: Reference/PathWhiz PW109228
xref: Reference/SMPDB SMP0108186
organism: Bos taurus

Reference/UniProt F1MZ60
type: UnificationXref
id: F1MZ60
db: UniProt

Activated CDC42 kinase 1
type: ProteinReference
xref: Reference/UniProt O02742
organism: Bos taurus

Uncharacterized protein
type: Protein
cellular location: Extracellular Space
entity reference: Uncharacterized protein

Reference/UniProt P79107
type: UnificationXref
id: P79107
db: UniProt

Reference/ChEBI CHEBI 16618
type: UnificationXref
id: CHEBI:16618
db: ChEBI

Leukotriene C4
type: SmallMolecule
cellular location: Cytosol
entity reference: Leukotriene C4
name: SubPathwayOutput

Synaptojanin-1
type: ProteinReference
xref: Reference/UniProt O18964
organism: Bos taurus

Reference/PubChem-compound 22833565
type: UnificationXref
id: 22833565
db: PubChem-compound

Dual specificity mitogen-activated protein kinase kinase 6
type: Complex
component stoichiometry: Protein/19407 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Dual specificity mitogen-activated protein kinase kinase 6

Arachidonic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Arachidonic acid
name: SubPathwayInput

Reference/UniProt A7YY51
type: UnificationXref
id: A7YY51
db: UniProt

Protein/19564 Extracellular Space/Stoichiometry/4.0
type: Stoichiometry
physical entity: Uncharacterized protein
stoichiometric coefficient: 4.0

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type
name: SubPathwayInput

Reference/KEGG Compound C00374
type: UnificationXref
id: C00374
db: KEGG Compound

Protein/19567 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low affinity immunoglobulin gamma Fc region receptor III
stoichiometric coefficient: 1.0

Reference/PubChem-compound 448457
type: UnificationXref
id: 448457
db: PubChem-compound

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004249
xref: Reference/KEGG Compound C05981
xref: Reference/ChEBI CHEBI 16618
xref: Reference/BioCyc PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
chemical formula: C12H24O22P4
molecular weight: 643.97095
structure: ChemicalStructure/PW C002108

Reference/UniProt Q3T0M4
type: UnificationXref
id: Q3T0M4
db: UniProt

Protein/19567 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low affinity immunoglobulin gamma Fc region receptor III
stoichiometric coefficient: 1.0

Reference/BioCyc PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
type: UnificationXref
id: PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
db: BioCyc

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt P08487
organism: Bos taurus

SubPathwayControl109210
type: Interaction
name: SubPathway109210Control
name: ActivatingSubPathwayControl
participant: Immunoglobulin Activation
participant: High affinity immunoglobulin epsilon receptor
participant: Immunoglobulin E

SubPathwayControl109211
type: Interaction
name: SubPathway109211Control
name: InhibitorySubPathwayControl
participant: Phosphatidylinositol-3,4,5-trisphosphate
participant: Synaptojanin-1
participant: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 inhibition of Phosphatidylinositol-3,4,5-trisphosphate

Lymphocyte cytosolic protein 2
type: ProteinReference
xref: Reference/UniProt F1MGR6
organism: Bos taurus

Protein/19592 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
stoichiometric coefficient: 1.0

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/UniProt Q2KJG8
type: UnificationXref
id: Q2KJG8
db: UniProt

Activated CDC42 kinase 1
type: Protein
cellular location: Cytosol
entity reference: Activated CDC42 kinase 1

Protein/19575 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyrosine-protein kinase Fyn
stoichiometric coefficient: 1.0

Synaptojanin-1
type: Protein
cellular location: Cytosol
entity reference: Synaptojanin-1
name: SubPathwayInhibitor

Protein/7764 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/UniProt A9QWQ7
type: UnificationXref
id: A9QWQ7
db: UniProt

Reference/UniProt A9QWQ8
type: UnificationXref
id: A9QWQ8
db: UniProt

Reference/KEGG Compound C05952
type: UnificationXref
id: C05952
db: KEGG Compound

Reference/KEGG Compound C00388
type: UnificationXref
id: C00388
db: KEGG Compound

Reference/KEGG Compound C05951
type: UnificationXref
id: C05951
db: KEGG Compound

Protein/19590 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GRB2-associated-binding protein 1
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Linker for activation of T cells
type: Protein
cellular location: Cytosol
entity reference: Linker for activation of T cells

Reference/UniProt E1BNU1
type: UnificationXref
id: E1BNU1
db: UniProt

Protein/19458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 13
stoichiometric coefficient: 1.0

Heparin
type: SmallMolecule
cellular location: Cytosol
entity reference: Heparin
name: SubPathwayOutput

Reference/SMPDB SMP0000075
type: UnificationXref
id: SMP0000075
db: SMPDB

ProteinComplex/11244 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
stoichiometric coefficient: 1.0

Protein/19600 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proto-oncogene vav
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003080
type: UnificationXref
id: HMDB0003080
db: HMDB

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Cytosol
entity reference: RAC-alpha serine/threonine-protein kinase
name: SubPathwayInput

Tumor necrosis factor
type: Complex
component stoichiometry: Protein/19650 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Tumor necrosis factor
name: SubPathwayOutput

Reference/CAS 51-45-6
type: UnificationXref
id: 51-45-6
db: CAS

Protein/19396 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Rap guanine nucleotide exchange factor 2
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002108
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Phosphatidylinositol-3,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-3,4,5-trisphosphate
name: SubPathwayInhibition

Protein/19618 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related C3 botulinum toxin substrate 1
stoichiometric coefficient: 1.0

High affinity immunoglobulin epsilon receptor
type: Complex
component stoichiometry: Protein/19570 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/19567 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/19572 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Membrane spanning 4-domains A2
component: High affinity immunoglobulin epsilon receptor subunit gamma
component: Low affinity immunoglobulin gamma Fc region receptor III
name: SubPathwayActivation
name: SubPathwayActivator

Reference/UniProt A2VE60
type: UnificationXref
id: A2VE60
db: UniProt

Tumor necrosis factor
type: ProteinReference
xref: Reference/UniProt Q27978
organism: Bos taurus

Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
type: UnificationXref
id: 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
db: BioCyc

Tumor necrosis factor
type: Protein
cellular location: Cytosol
entity reference: Tumor necrosis factor

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt A2VE60
organism: Bos taurus

Reference/UniProt G3N342
type: UnificationXref
id: G3N342
db: UniProt

SubPathwayInteraction109214
type: Interaction
name: SubPathway109214Reaction
name: SubPathwayReaction
participant: Histamine
participant: Protein kinase C alpha type
participant: Calcium
participant: Heparin

Reference/UniProt Q9TV84
type: UnificationXref
id: Q9TV84
db: UniProt

SubPathwayInteraction109213
type: Interaction
name: SubPathway109213Reaction
name: SubPathwayReaction
participant: Prostaglandin D2
participant: Arachidonic acid
participant: Leukotriene D4
participant: Leukotriene C4
participant: Leukotriene E4

SubPathwayInteraction109216
type: Interaction
name: SubPathway109216Reaction
name: SubPathwayReaction
participant: Dual specificity mitogen-activated protein kinase kinase 6

SubPathwayInteraction109215
type: Interaction
name: SubPathwayReaction
name: SubPathway109215Reaction
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Proto-oncogene vav
type: Protein
cellular location: Cytosol
entity reference: Proto-oncogene vav

SubPathwayInteraction109212
type: Interaction
name: SubPathway109212Reaction
name: SubPathwayReaction
participant: Granulocyte-macrophage colony-stimulating factor
participant: RAC-alpha serine/threonine-protein kinase
participant: Mitogen-activated protein kinase 13
participant: Tumor necrosis factor
participant: Protein kinase C alpha type
participant: Unknown
participant: Interleukin-5
participant: Mitogen-activated protein kinase 1
participant: Interleukin-4
participant: Interleukin-13

Prostaglandin D2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15555
xref: Reference/ChemSpider 395250
xref: Reference/HMDB HMDB0001403
xref: Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
xref: Reference/PubChem-compound 448457
xref: Reference/KEGG Compound C00696
xref: Reference/CAS 41598-07-6
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001084

Membrane spanning 4-domains A2
type: Protein
cellular location: Cytosol
entity reference: Membrane spanning 4-domains A2

Reference/UniProt P08487
type: UnificationXref
id: P08487
db: UniProt

Reference/UniProt Q3SZX3
type: UnificationXref
id: Q3SZX3
db: UniProt

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C05981
type: UnificationXref
id: C05981
db: KEGG Compound

Reference/UniProt A0JNB0
type: UnificationXref
id: A0JNB0
db: UniProt

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Histamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Histamine
name: SubPathwayOutput

Reference/HMDB HMDB0002200
type: UnificationXref
id: HMDB0002200
db: HMDB

Reference/PubChem-compound 5280878
type: UnificationXref
id: 5280878
db: PubChem-compound

Prostaglandin D2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin D2
name: SubPathwayOutput

Reference/PathWhiz PW109228
type: UnificationXref
id: PW109228
db: PathWhiz

Reference/UniProt Q08DN7
type: UnificationXref
id: Q08DN7
db: UniProt

Reference/UniProt O02742
type: UnificationXref
id: O02742
db: UniProt

Mitogen-activated protein kinase 13
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 13
name: SubPathwayInput

Protein/19650 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Tumor necrosis factor
stoichiometric coefficient: 3.0

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Low affinity immunoglobulin gamma Fc region receptor III
type: Protein
cellular location: Cytosol
entity reference: Low affinity immunoglobulin gamma Fc region receptor III

ProteinComplex/11241 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 3-kinase
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001485
type: ChemicalStructure
structure format: SMILES

Phosphatidylinositol 3-kinase
type: Complex
component stoichiometry: Protein/16922 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/17373 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Phosphatidylinositol 3-kinase regulatory subunit alpha
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: Reference/UniProt P23727
organism: Bos taurus

Ras-related protein Rap-1b
type: ProteinReference
xref: Reference/UniProt Q3T0M4
organism: Bos taurus

Reference/ChEBI CHEBI 15555
type: UnificationXref
id: CHEBI:15555
db: ChEBI

Reference/ChemSpider 4444401
type: UnificationXref
id: 4444401
db: ChemSpider

Reference/ChemSpider 4444402
type: UnificationXref
id: 4444402
db: ChemSpider

Reference/PubChem-compound 774
type: UnificationXref
id: 774
db: PubChem-compound

SubPathwayInteraction109217
type: Interaction
name: SubPathwayReaction
name: SubPathway109217Reaction
participant: Arachidonic acid

Reference/UniProt A6QLU3
type: UnificationXref
id: A6QLU3
db: UniProt

Protein/19572 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: High affinity immunoglobulin epsilon receptor subunit gamma
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Heparin
type: SmallMoleculeReference
xref: Reference/CAS 9005-49-6
xref: Reference/ChEBI CHEBI 28304
xref: Reference/KEGG Compound C00374
xref: Reference/ChemSpider 17216115
xref: Reference/HMDB HMDB0001394
xref: Reference/BioCyc HEPARIN
xref: Reference/PubChem-compound 22833565
chemical formula: (C12H19NO19S3)nH2O
structure: ChemicalStructure/PW C001078

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt G3N342
organism: Bos taurus

Low affinity immunoglobulin gamma Fc region receptor III
type: ProteinReference
xref: Reference/UniProt P79107
organism: Bos taurus

Compound/PW C002108 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-3,4,5-trisphosphate
stoichiometric coefficient: 1.0

Compound/PW C000821 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Reference/UniProt F1MSG6
type: UnificationXref
id: F1MSG6
db: UniProt

Interleukin-4
type: Protein
cellular location: Cytosol
entity reference: Interleukin-4
name: SubPathwayOutput

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
type: Complex
component stoichiometry: Protein/19615 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Protein/19608 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase C alpha type
stoichiometric coefficient: 1.0

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt Q3ZBW9
organism: Bos taurus

Protein/19413 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Immunoglobulin Activation
type: Pathway
name: ActivatingSubPathway

Protein/19409 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Arachidonic Acid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109217
pathway component: SubPathwayInteraction109217
xref: Reference/PathWhiz PW000044
xref: Reference/SMPDB SMP0000075
name: SubPathway

GRB2-related adapter protein
type: Protein
cellular location: Cytosol
entity reference: GRB2-related adapter protein

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

GRB2-associated-binding protein 1
type: Protein
cellular location: Cytosol
entity reference: GRB2-associated-binding protein 1

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q2KJG8
organism: Bos taurus

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/BioCyc HISTAMINE
type: UnificationXref
id: HISTAMINE
db: BioCyc

Phosphatidylinositol signaling system
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109215
pathway component: SubPathwayInteraction109215
name: SubPathway

Reference/HMDB HMDB0032436
type: UnificationXref
id: HMDB0032436
db: HMDB

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

MAPK signaling pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109216
pathway component: SubPathwayInteraction109216
name: SubPathway

Generation of eicosanoids
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109213
pathway component: SubPathwayInteraction109213
name: SubPathway

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cytosol
entity reference: Ras-related C3 botulinum toxin substrate 1

Degranulation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109214
pathway component: SubPathwayInteraction109214
name: SubPathway

Reference/SMPDB SMP0108186
type: UnificationXref
id: SMP0108186
db: SMPDB

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 inhibition of Phosphatidylinositol-3,4,5-trisphosphate
type: Pathway
name: InhibitorySubPathway

Lymphocyte cytosolic protein 2
type: Protein
cellular location: Cytosol
entity reference: Lymphocyte cytosolic protein 2

Cytokine gene transcription
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109212
pathway component: SubPathwayInteraction109212
name: SubPathway

Mono- and diglycerides
type: SmallMolecule
cellular location: Cytosol
entity reference: Mono- and diglycerides

ChemicalStructure/PW C001078
type: ChemicalStructure
structure format: SMILES

Protein/19407 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 2.0

Reference/ChemSpider 395250
type: UnificationXref
id: 395250
db: ChemSpider

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 6
name: SubPathwayInput

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt Q5ER96
organism: Bos taurus

Reference/UniProt P11052
type: UnificationXref
id: P11052
db: UniProt

Reference/UniProt P04409
type: UnificationXref
id: P04409
db: UniProt

Reference/HMDB HMDB0001394
type: UnificationXref
id: HMDB0001394
db: HMDB

GRB2-related adapter protein
type: ProteinReference
xref: Reference/UniProt A6QLK6
organism: Bos taurus

Reference/UniProt Q3ZBW9
type: UnificationXref
id: Q3ZBW9
db: UniProt

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cytosol
entity reference: Rap guanine nucleotide exchange factor 2

Reference/CAS 72025-60-6
type: UnificationXref
id: 72025-60-6
db: CAS

Reference/ChemSpider 5254058
type: UnificationXref
id: 5254058
db: ChemSpider

Protein/16922 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
stoichiometric coefficient: 1.0

Protein/19430 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related protein Rap-1b
stoichiometric coefficient: 1.0

High affinity immunoglobulin epsilon receptor subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: High affinity immunoglobulin epsilon receptor subunit gamma

Leukotriene D4
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28666
xref: Reference/ChemSpider 4444401
xref: Reference/HMDB HMDB0003080
xref: Reference/CAS 73836-78-9
xref: Reference/KEGG Compound C05951
xref: Reference/PubChem-compound 5280878
chemical formula: C25H40N2O6S
molecular weight: 496.2607
structure: ChemicalStructure/PW C001775

Reference/ChEBI CHEBI 18295
type: UnificationXref
id: CHEBI:18295
db: ChEBI

Reference/UniProt Q5E9X2
type: UnificationXref
id: Q5E9X2
db: UniProt

Reference/UniProt Q27978
type: UnificationXref
id: Q27978
db: UniProt

Reference/CAS 41598-07-6
type: UnificationXref
id: 41598-07-6
db: CAS

Reference/HMDB HMDB0000870
type: UnificationXref
id: HMDB0000870
db: HMDB

Reference/ChemSpider 753
type: UnificationXref
id: 753
db: ChemSpider

Reference/UniProt Q5ER96
type: UnificationXref
id: Q5ER96
db: UniProt

Reference/ChEBI CHEBI 28666
type: UnificationXref
id: CHEBI:28666
db: ChEBI

Reference/ChEBI CHEBI 28304
type: UnificationXref
id: CHEBI:28304
db: ChEBI

Reference/PubChem-compound 6850771
type: UnificationXref
id: 6850771
db: PubChem-compound

Reference/PubChem-compound 5280749
type: UnificationXref
id: 5280749
db: PubChem-compound

Histamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000870
xref: Reference/ChemSpider 753
xref: Reference/PubChem-compound 774
xref: Reference/BioCyc HISTAMINE
xref: Reference/CAS 51-45-6
xref: Reference/ChEBI CHEBI 18295
xref: Reference/KEGG Compound C00388
chemical formula: C5H9N3
molecular weight: 111.07965
structure: ChemicalStructure/PW C000693

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt P32871
organism: Bos taurus

Interleukin-5
type: Protein
cellular location: Cytosol
entity reference: Interleukin-5

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt A7YY51
organism: Bos taurus

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Protein/19628 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GRB2-related adapter protein
stoichiometric coefficient: 1.0

Protein/19646 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Interleukin-5
stoichiometric coefficient: 2.0

Reference/UniProt O18964
type: UnificationXref
id: O18964
db: UniProt

Unknown
type: ProteinReference
organism: Bos taurus

Reference/KEGG Compound C02166
type: UnificationXref
id: C02166
db: KEGG Compound

Interleukin-13
type: Protein
cellular location: Cytosol
entity reference: Interleukin-13
name: SubPathwayOutput

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Reference/CAS 67254-73-3
type: UnificationXref
id: 67254-73-3
db: CAS

Interleukin-4
type: ProteinReference
xref: Reference/UniProt A9QWQ7
organism: Bos taurus

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Interleukin-13
type: ProteinReference
xref: Reference/UniProt Q9TV84
organism: Bos taurus

Interleukin-5
type: ProteinReference
xref: Reference/UniProt A9QWQ8
organism: Bos taurus

Granulocyte-macrophage colony-stimulating factor
type: ProteinReference
xref: Reference/UniProt P11052
organism: Bos taurus

Reference/CAS 73836-78-9
type: UnificationXref
id: 73836-78-9
db: CAS

Protein/19407 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

Reference/UniProt P23727
type: UnificationXref
id: P23727
db: UniProt

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt Q5E9X2
organism: Bos taurus