Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 9
type: Protein
entity reference: Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 9

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 57-13-6
type: UnificationXref
id: 57-13-6
db: CAS

Solute carrier family 3 (Cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
type: Protein
entity reference: Solute carrier family 3 (Cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1

Active Mineralocorticoid receptor (Bos taurus)_Aldosterone
type: Complex
component stoichiometry: ProteinComplex/10924 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C000026 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aldosterone
component: Active Mineralocorticoid receptor
name: SubPathwayInput

Reference/ChEBI CHEBI 33709
type: UnificationXref
id: CHEBI:33709
db: ChEBI

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

L-Cysteine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Cysteine

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Imino acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Imino acids

H(+)/Cl(-) exchange transporter 7
type: ProteinReference
xref: Reference/UniProt Q4PKH3

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

SLC7A7 protein
type: Protein
entity reference: SLC7A7 protein

Compound/Generic51 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Compound/PW C000026 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

Reference/ChemSpider 1143
type: UnificationXref
id: 1143
db: ChemSpider

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Blood-brain barrier large neutral amino acid transporter
type: Protein
entity reference: Blood-brain barrier large neutral amino acid transporter

Sodium-dependent neutral amino acid transporter B(0)AT2
type: Protein
entity reference: Sodium-dependent neutral amino acid transporter B(0)AT2

Reference/BioCyc UREA
type: UnificationXref
id: UREA
db: BioCyc

Reference/UniProt Q3ZCL6
type: UnificationXref
id: Q3ZCL6
db: UniProt

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2
type: Protein
entity reference: Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt Q08DA1
organism: Bos taurus

Compound/Generic39 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Compound/PW C000374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Reference/UniProt Q95135
type: UnificationXref
id: Q95135
db: UniProt

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Urea
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Urea

Reference/ChEBI CHEBI 26271
type: UnificationXref
id: CHEBI:26271
db: ChEBI

Solute carrier family 7 member 10
type: Protein
entity reference: Solute carrier family 7 member 10

ChemicalStructure/PW C000200
type: ChemicalStructure
structure format: SMILES
structure data: NC(N)=O

Epithelial Sodium Channel
type: Complex
cellular location: Cell Membrane
component: Unknown
name: SubPathwayOutput

Reference/ChEBI CHEBI 15705
type: UnificationXref
id: CHEBI:15705
db: ChEBI

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Imino acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Imino acids

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

L-Amino acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15705

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

SLC7A7 protein
type: ProteinReference
xref: Reference/UniProt Q0V8M6

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Large Neutral Amino Acids

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Chloride ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chloride ion

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 25697
type: UnificationXref
id: CHEBI:25697
db: ChEBI

Reference/ChEBI CHEBI 25696
type: UnificationXref
id: CHEBI:25696
db: ChEBI

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
type: Complex
component: Blood-brain barrier large neutral amino acid transporter
component: Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
type: Complex
component: Solute carrier family 7 member 10
component: Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 9
type: ProteinReference
xref: Reference/UniProt Q3ZCL6

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Urea
type: SmallMolecule
cellular location: Cytosol
entity reference: Urea

SLC3A2/4F2hc Y+L amino acid transporter 2
type: Complex
component: SLC7A7 protein
component: Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2

SLC3A2/4F2hc Y+L amino acid transporter 1
type: Complex
component: SLC7A7 protein
component: Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2

Compound/Generic50 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/UniProt Q95M41
type: UnificationXref
id: Q95M41
db: UniProt

Solute carrier family 3 (Cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
type: ProteinReference
xref: Reference/UniProt Q3SZF7

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/UniProt Q0V8M6
type: UnificationXref
id: Q0V8M6
db: UniProt

Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

TransportCatalysis1301
type: Catalysis
controller: Epithelial Sodium Channel
controlled: Transport10093
control type: ACTIVATION

TransportCatalysis1304
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
controlled: Transport10095
control type: ACTIVATION

TransportCatalysis1303
type: Catalysis
controller: Excitatory amino acid transporter 3
controlled: Transport10094
control type: ACTIVATION

Organic Anion
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Anion

Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
type: Complex
component: Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 9
component: Solute carrier family 3 (Cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1

TransportCatalysis1306
type: Catalysis
controller: Sodium-dependent neutral amino acid transporter B(0)AT2
controlled: Transport10096
control type: ACTIVATION

Transport10101
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

TransportCatalysis1305
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
controlled: Transport10095
control type: ACTIVATION

Transport10102
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10103
type: Transport
participant stoichiometry: Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
spontaneous: false
left: L-Cysteine
name: L-Cysteine (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

TransportCatalysis1307
type: Catalysis
controller: Sodium-coupled neutral amino acid transporter 2
controlled: Transport10097
control type: ACTIVATION

Protein/7764 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Transport10100
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Active Mineralocorticoid receptor
type: Complex
component stoichiometry: Protein/7764 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Unknown

Urea transporter 1
type: ProteinReference
xref: Reference/UniProt Q2TM53

Transcription/Translation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109313
pathway component: SubPathwayInteraction109313
xref: Reference/SMPDB SMP0000019
xref: Reference/PathWhiz PW000455
name: SubPathway

TransportCatalysis1313
type: Catalysis
controller: Urea transporter 1
controlled: Transport10100
control type: ACTIVATION

TransportCatalysis1312
type: Catalysis
controller: Urea transporter 1
controlled: Transport10099
control type: ACTIVATION

TransportCatalysis1314
type: Catalysis
controller: Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
controlled: Transport10103
control type: ACTIVATION

TransportCatalysis1311
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 2
controlled: Transport10098
control type: ACTIVATION

TransportCatalysis1310
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 1
controlled: Transport10098
control type: ACTIVATION

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Large Neutral Amino Acids

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/Generic32 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Organic Anion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Anion

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/UniProt Q3T0C6
type: UnificationXref
id: Q3T0C6
db: UniProt

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Compound/Generic39 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Excitatory amino acid transporter 3
type: Protein
entity reference: Excitatory amino acid transporter 3

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

TransportCatalysis1298
type: Catalysis
controller: Unknown
controlled: Transport10085
control type: ACTIVATION

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/SMPDB SMP0000019
type: UnificationXref
id: SMP0000019
db: SMPDB

Unknown
type: Protein
cellular location: Nucleus
entity reference: Unknown

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000455
type: UnificationXref
id: PW000455
db: PathWhiz

TransportCatalysis1299
type: Catalysis
controller: H(+)/Cl(-) exchange transporter 7
controlled: Transport10087
control type: ACTIVATION

Reference/UniProt Q08DA1
type: UnificationXref
id: Q08DA1
db: UniProt

ProteinComplex/10924 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor
stoichiometric coefficient: 1.0

Sodium/potassium ATPase
type: Complex
cellular location: Cell Membrane
component: Unknown
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-1
name: SubPathwayOutput

Compound/Generic5 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Sodium-coupled neutral amino acid transporter 2
type: Protein
entity reference: Sodium-coupled neutral amino acid transporter 2

Compound/PW C000200 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Imino acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26271

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Urea
type: SmallMoleculeReference
xref: Reference/BioCyc UREA
xref: Reference/CAS 57-13-6
xref: Reference/KEGG Compound C00086
xref: Reference/HMDB HMDB0000294
xref: Reference/ChemSpider 1143
xref: Reference/PubChem-compound 1176
xref: Reference/ChEBI CHEBI 16199
chemical formula: CH4N2O
molecular weight: 60.032364
structure: ChemicalStructure/PW C000200

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Aldosterone
type: SmallMolecule
cellular location: Nucleus
entity reference: Aldosterone

Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Compound/Generic5 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt Q2TM53
type: UnificationXref
id: Q2TM53
db: UniProt

Solute carrier family 7 member 10
type: ProteinReference
xref: Reference/UniProt G3MXA4

Reference/ChEBI CHEBI 16199
type: UnificationXref
id: CHEBI:16199
db: ChEBI

L-Amino acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Amino acid

Reference/UniProt Q3SZF7
type: UnificationXref
id: Q3SZF7
db: UniProt

Large Neutral Amino Acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 33709

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Unknown
type: Protein
entity reference: Unknown

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Organic Cation
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25697

Blood-brain barrier large neutral amino acid transporter
type: ProteinReference
xref: Reference/UniProt Q9TU26

Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2
type: ProteinReference
xref: Reference/UniProt Q5EA54

Epithelial Sodium Channel
type: Complex
component: Unknown

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

Sodium-dependent neutral amino acid transporter B(0)AT2
type: ProteinReference
xref: Reference/UniProt Q9XS59

Organic Anion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25696

Transport10097
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10098
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10099
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW120599
type: UnificationXref
id: PW120599
db: PathWhiz

Compound/Generic32 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Transport10093
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10094
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: L-Amino acid
right: Sodium
spontaneous: false
left: Sodium
left: L-Amino acid
name: L-Amino acid (→), Sodium (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10095
type: Transport
participant stoichiometry: Compound/Generic50 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic50 Extracellular Space/Stoichiometry/1.0
right: Large Neutral Amino Acids
spontaneous: false
left: Large Neutral Amino Acids
name: Large Neutral Amino Acids (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10096
type: Transport
participant stoichiometry: Compound/Generic51 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic51 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Imino acids
right: Chloride ion
right: Sodium
spontaneous: false
left: Imino acids
left: Sodium
left: Chloride ion
name: Imino acids (→), Sodium (→), Chloride ion (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0119376
type: UnificationXref
id: SMP0119376
db: SMPDB

Transport10090
type: Transport
participant stoichiometry: Compound/Generic32 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic32 Cytosol/Stoichiometry/1.0
right: Organic Anion
spontaneous: false
left: Organic Anion
name: Organic Anion (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10091
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
spontaneous: false
left: Chloride ion
left: Potassium
name: Chloride ion (→), Potassium (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q9XS59
type: UnificationXref
id: Q9XS59
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Transport10092
type: Transport
participant stoichiometry: Compound/Generic39 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic39 Extracellular Space/Stoichiometry/1.0
right: Organic Cation
spontaneous: false
left: Organic Cation
name: Organic Cation (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt Q5EA54
type: UnificationXref
id: Q5EA54
db: UniProt

Kidney Function
type: Pathway
pathway order: PathwayTransport/2118939
pathway order: PathwayTransport/2118938
pathway order: PathwayTransport/2118949
pathway order: PathwayTransport/2118937
pathway order: PathwayTransport/2118948
pathway order: PathwayTransport/2118936
pathway order: PathwayTransport/2118947
pathway order: PathwayTransport/2118942
pathway order: PathwayTransport/2118953
pathway order: PathwayTransport/2118941
pathway order: PathwayTransport/2118940
pathway order: PathwayTransport/2118950
pathway order: PathwayTransport/2118935
pathway order: PathwayTransport/2118946
pathway order: PathwayTransport/2118957
pathway order: PathwayTransport/2118945
pathway order: PathwayTransport/2118956
pathway order: PathwaySubPathway/109313
pathway order: PathwayTransport/2118944
pathway order: PathwayTransport/2118955
pathway order: PathwayTransport/2118943
pathway order: PathwayTransport/2118954
pathway component: TransportCatalysis1301
pathway component: TransportCatalysis1304
pathway component: TransportCatalysis1303
pathway component: TransportCatalysis1306
pathway component: Transport10101
pathway component: TransportCatalysis1305
pathway component: Transport10102
pathway component: Transport10103
pathway component: TransportCatalysis1307
pathway component: Transport10086
pathway component: Transport10087
pathway component: Transport10088
pathway component: Transport10089
pathway component: Transport10100
pathway component: Transport10085
pathway component: Transcription/Translation
pathway component: TransportCatalysis1313
pathway component: TransportCatalysis1312
pathway component: TransportCatalysis1314
pathway component: TransportCatalysis1298
pathway component: TransportCatalysis1311
pathway component: TransportCatalysis1299
pathway component: TransportCatalysis1310
pathway component: Transport10097
pathway component: Transport10098
pathway component: Transport10099
pathway component: Transport10093
pathway component: Transport10094
pathway component: Transport10095
pathway component: Transport10096
pathway component: Transport10090
pathway component: Transport10091
pathway component: Transport10092
xref: Reference/PathWhiz PW120599
xref: Reference/SMPDB SMP0119376
organism: Bos taurus

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1176
type: UnificationXref
id: 1176
db: PubChem-compound

Transport10086
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10087
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
right: Chloride ion
spontaneous: false
left: Chloride ion
name: Chloride ion (→) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Transport10088
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (↔) Transport: Bos taurus, Cell, Cytosol to Bos taurus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Organic Cation
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Cation

Transport10089
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
left: Potassium
name: Sodium (→), Potassium (→), Chloride ion (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q9TU26
type: UnificationXref
id: Q9TU26
db: UniProt

Transport10085
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
name: Chloride ion (→), Sodium (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000374 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Sodium-coupled neutral amino acid transporter 2
type: ProteinReference
xref: Reference/UniProt Q95M41

Hydrogen carbonate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen carbonate

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt A2VDL6
organism: Bos taurus

Reference/HMDB HMDB0000294
type: UnificationXref
id: HMDB0000294
db: HMDB

H(+)/Cl(-) exchange transporter 7
type: Protein
entity reference: H(+)/Cl(-) exchange transporter 7

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/KEGG Compound C00086
type: UnificationXref
id: C00086
db: KEGG Compound

Compound/Generic51 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Excitatory amino acid transporter 3
type: ProteinReference
xref: Reference/UniProt Q95135

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt Q28030
organism: Bos taurus

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt Q3T0C6
organism: Bos taurus

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt Q04645
organism: Bos taurus

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

L-Amino acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Amino acid

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

SubPathwayInteraction109313
type: Interaction
name: SubPathway109313Reaction
name: SubPathwayReaction
participant: Sodium/potassium ATPase
participant: Epithelial Sodium Channel
participant: Active Mineralocorticoid receptor (Bos taurus)_Aldosterone

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Organic Cation
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Cation

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/UniProt A2VDL6
type: UnificationXref
id: A2VDL6
db: UniProt

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

Reference/UniProt Q04645
type: UnificationXref
id: Q04645
db: UniProt

Compound/Generic50 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Reference/UniProt Q4PKH3
type: UnificationXref
id: Q4PKH3
db: UniProt

Urea transporter 1
type: Protein
entity reference: Urea transporter 1

Reference/UniProt Q28030
type: UnificationXref
id: Q28030
db: UniProt

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

Reference/UniProt G3MXA4
type: UnificationXref
id: G3MXA4
db: UniProt

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0