ReactionCatalysis168914
type: Catalysis
controller: Tissue factor:Coagulation factor VIIa
controlled: 3.4.21.22
control type: ACTIVATION

ReactionCatalysis168913
type: Catalysis
controller: Tenase complex
controlled: 3.4.21.22
control type: ACTIVATION

Compound/PW C002089/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced Vitamin K (phylloquinone)
stoichiometric coefficient: 1.0

ReactionCatalysis168912
type: Catalysis
controller: Prothrombin
controlled: 3.4.21.5
control type: ACTIVATION

Fibrinogen gamma-B chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen gamma-B chain

BiologicalState429
type: BioSource
xref: Reference/TAXONOMY 9913
name: Bos taurus, Liver
tissue: Liver

ReactionCatalysis168911
type: Catalysis
controller: Prothrombin
controlled: 3.4.21.5
control type: ACTIVATION

ReactionCatalysis168910
type: Catalysis
controller: Coagulation factor XI
controlled: 3.4.21.27
control type: ACTIVATION

Protein/20369/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor X
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05849
type: UnificationXref
id: C05849
db: KEGG Compound

Collagen alpha-1(I) chain
type: Protein
cellular location: Extracellular Space
entity reference: Collagen alpha-1(I) chain
name: SubPathwayActivator

Coagulation factor X
type: ProteinReference
xref: Reference/UniProt P00743
organism: Bos taurus

Tissue factor
type: ProteinReference
xref: Reference/UniProt Q08DD5

Coagulation factor VII
type: ProteinReference
xref: Reference/UniProt Q58DL3

Tenase complex
type: Complex
cellular location: Extracellular Space
component: Coagulation factor IX
component: Coagulation factor V

ProteinComplex/11665 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (loose)
stoichiometric coefficient: 1.0

Plasminogen
type: Protein
cellular location: Extracellular Space
entity reference: Plasminogen

Coagulation factor IX
type: ProteinReference
xref: Reference/UniProt F1MFL4
organism: Bos taurus

Reference/PubChem-compound 5284607
type: UnificationXref
id: 5284607
db: PubChem-compound

Coagulation factor V
type: ProteinReference
xref: Reference/UniProt Q28108
organism: Bos taurus

SubPathwayControl109317
type: Interaction
name: SubPathway109317Control
name: ActivatingSubPathwayControl
participant: Protein-glutamine gamma-glutamyltransferase E
participant: Coagulation factor XIII A and B activate to Coagulation factor XIIIa
participant: Complement factor H
participant: Coagulation factor XIIIa

SubPathwayControl109318
type: Interaction
name: SubPathway109318Control
name: ActivatingSubPathwayControl
participant: Coagulation factor VII
participant: Tissue factor
participant: Activate Coagulatin factor VII to VIIa by binding to Tissue Factor
participant: Tissue factor:Coagulation factor VIIa

ReactionCatalysis168909
type: Catalysis
controller: Coagulation factor XII
controlled: 3.4.21.38
control type: ACTIVATION

SubPathwayControl109314
type: Interaction
name: SubPathway109314Control
name: ActivatingSubPathwayControl
participant: Collagen alpha-1(I) chain
participant: Coagulation factor XII
participant: XII activated to XIIa by Collagen

SubPathwayControl109315
type: Interaction
name: SubPathway109315Control
name: ActivatingSubPathwayControl
participant: Plasma kallikrein
participant: Coagulation factor XII
participant: XII activated to XIIa by Plasma kallikrein

SubPathwayControl109316
type: Interaction
name: SubPathway109316Control
name: ActivatingSubPathwayControl
participant: Plasma kallikrein
participant: Plasma prekallikrein activated to Plasma kallikrein by XIIa
participant: Coagulation factor XII

Reference/ChemSpider 82688
type: UnificationXref
id: 82688
db: ChemSpider

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/ChemSpider 4447652
type: UnificationXref
id: 4447652
db: ChemSpider

Reference/UniProt F1MFL4
type: UnificationXref
id: F1MFL4
db: UniProt

Fibrinogen gamma-B chain
type: ProteinReference
xref: Reference/UniProt P12799
organism: Bos taurus

Reference/KEGG Compound C05850
type: UnificationXref
id: C05850
db: KEGG Compound

Coagulation factor X
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor X

Fibrinogen alpha chain
type: ProteinReference
xref: Reference/UniProt Q3T049
organism: Bos taurus

Reference/UniProt A6QP57
type: UnificationXref
id: A6QP57
db: UniProt

Prothrombin and coagulation factors VII, IX and X
type: Protein
entity reference: Prothrombin and coagulation factors VII, IX and X

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Protein/20369 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor X
stoichiometric coefficient: 1.0

Fibrinogen beta chain
type: ProteinReference
xref: Reference/UniProt P02676
organism: Bos taurus

ChemicalStructure/PW C002089
type: ChemicalStructure
structure format: SMILES

Protein/Generic45/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin and coagulation factors VII, IX and X
stoichiometric coefficient: 1.0

Vitamin K epoxide reductase complex subunit 1
type: Protein
entity reference: Vitamin K epoxide reductase complex subunit 1

3.4.21.38
type: BiochemicalReaction
participant stoichiometry: Protein/20355/Stoichiometry/1.0
right: Coagulation factor XI
spontaneous: false
EC number: 3.4.21.38
left: Coagulation factor XI
name: Coagulation factor XI → Coagulation factor XIa
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt Q3MHM2
type: UnificationXref
id: Q3MHM2
db: UniProt

Fibrinogen
type: Complex
cellular location: Extracellular Space
component: Fibrinogen gamma-B chain
component: Fibrinogen beta chain
component: Fibrinogen alpha chain

ProteinComplex/11666 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (mesh)
stoichiometric coefficient: 1.0

Reference/UniProt Q28108
type: UnificationXref
id: Q28108
db: UniProt

Protein-glutamine gamma-glutamyltransferase E
type: ProteinReference
xref: Reference/UniProt A6QP57
organism: Bos taurus

Tissue-type plasminogen activator
type: Protein
cellular location: Extracellular Space
entity reference: Tissue-type plasminogen activator

Reference/HMDB HMDB0002972
type: UnificationXref
id: HMDB0002972
db: HMDB

Complement factor H
type: ProteinReference
xref: Reference/UniProt Q9TQZ7
organism: Bos taurus

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: Protein/20362 Extracellular Space/Stoichiometry/1.0
right: Coagulation factor V
spontaneous: false
EC number: 3.4.21.5
left: Coagulation factor V
name: Coagulation factor V → Coagulation factor Va
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P02676
type: UnificationXref
id: P02676
db: UniProt

Reference/HMDB HMDB0004198
type: UnificationXref
id: HMDB0004198
db: HMDB

3.4.21.22
type: BiochemicalReaction
participant stoichiometry: Protein/20369 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/20369/Stoichiometry/1.0
right: Coagulation factor X
spontaneous: false
EC number: 3.4.21.22
left: Coagulation factor X
name: Coagulation factor X → Coagulation factor Xa
conversion direction: LEFT_TO_RIGHT

Vitamin K-dependent gamma-carboxylase
type: ProteinReference
xref: Reference/UniProt Q07175

3.4.21.27
type: BiochemicalReaction
participant stoichiometry: Protein/20360 Extracellular Space/Stoichiometry/1.0
right: Coagulation factor IX
spontaneous: false
EC number: 3.4.21.27
left: Coagulation factor IX
name: Coagulation factor IX → Coagulation factor IXa
conversion direction: LEFT_TO_RIGHT

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: Protein/20362 Extracellular Space/Stoichiometry/1.0
right: Coagulation factor V
spontaneous: false
EC number: 3.4.21.5
left: Coagulation factor V
name: Coagulation factor VIII → Coagulation factor VIIIa
conversion direction: LEFT_TO_RIGHT

Protein-glutamine gamma-glutamyltransferase E
type: Protein
cellular location: Extracellular Space
entity reference: Protein-glutamine gamma-glutamyltransferase E

Activate Coagulatin factor VII to VIIa by binding to Tissue Factor
type: Pathway
name: ActivatingSubPathway

Plasma prekallikrein activated to Plasma kallikrein by XIIa
type: Pathway
name: ActivatingSubPathway

Protein/20355/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor XI
stoichiometric coefficient: 1.0

Coagulation factor XIII A and B activate to Coagulation factor XIIIa
type: Pathway
name: ActivatingSubPathway

Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
type: UnificationXref
id: 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
db: BioCyc

XII activated to XIIa by Collagen
type: Pathway
name: ActivatingSubPathway

XII activated to XIIa by Plasma kallikrein
type: Pathway
name: ActivatingSubPathway

Vitamin K1 2,3-epoxide
type: SmallMoleculeReference
xref: Reference/ChemSpider 82688
xref: Reference/HMDB HMDB0002972
xref: Reference/CAS 25486-55-9
xref: Reference/PubChem-compound 91577
xref: Reference/KEGG Compound C05849
xref: Reference/ChEBI CHEBI 28371
xref: Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
chemical formula: C31H46O3
molecular weight: 466.3447
structure: ChemicalStructure/PW C001746

Protein/16197 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin
stoichiometric coefficient: 1.0

Vitamin K-dependent gamma-carboxylase
type: Protein
entity reference: Vitamin K-dependent gamma-carboxylase

Tissue-type plasminogen activator
type: ProteinReference
xref: Reference/UniProt Q2KJG9
organism: Bos taurus

Plasminogen
type: ProteinReference
xref: Reference/UniProt Q28162
organism: Bos taurus

Protein/20362 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor V
stoichiometric coefficient: 1.0

Fibrinogen beta chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen beta chain

Coagulation factor XIIIa
type: Complex
cellular location: Extracellular Space
component: Complement factor H
component: Protein-glutamine gamma-glutamyltransferase E

Reference/SMPDB SMP0119377
type: UnificationXref
id: SMP0119377
db: SMPDB

Protein-glutamine gamma-glutamyltransferase E
type: Protein
entity reference: Protein-glutamine gamma-glutamyltransferase E
name: SubPathwayActivator

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: Protein
cellular location: Extracellular Space
entity reference: Precursors of Prothrombin and coagulation factors VII, IX, ad X

Reference/UniProt A2VDX1
type: UnificationXref
id: A2VDX1
db: UniProt

Fibrin (loose)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen gamma-B chain
component: Fibrinogen beta chain
component: Fibrinogen alpha chain

Complement factor H
type: Protein
entity reference: Complement factor H
name: SubPathwayActivator

Reference/UniProt Q3MHK7
type: UnificationXref
id: Q3MHK7
db: UniProt

Fibrin degradation products
type: Complex
cellular location: Extracellular Space
component: Fibrinogen gamma-B chain
component: Fibrinogen beta chain
component: Fibrinogen alpha chain

Unknown
type: Protein
cellular location: Extracellular Space
entity reference: Unknown

Prothrombin and coagulation factors VII, IX and X
type: Protein
cellular location: Extracellular Space
entity reference: Prothrombin and coagulation factors VII, IX and X

Vitamin K1 2,3-epoxide
type: SmallMolecule
entity reference: Vitamin K1 2,3-epoxide

Reference/UniProt Q08DD5
type: UnificationXref
id: Q08DD5
db: UniProt

ProteinComplex/11667 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin degradation products
stoichiometric coefficient: 1.0

Reference/CAS 84-80-0
type: UnificationXref
id: 84-80-0
db: CAS

Protein/7764 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Protein/Generic44 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Precursors of Prothrombin and coagulation factors VII, IX, ad X
stoichiometric coefficient: 1.0

Reference/UniProt Q28162
type: UnificationXref
id: Q28162
db: UniProt

Fibrin (mesh)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen gamma-B chain
component: Fibrinogen beta chain
component: Fibrinogen alpha chain

Vitamin K-dependent gamma-carboxylase
type: Protein
cellular location: Extracellular Space
entity reference: Vitamin K-dependent gamma-carboxylase

Coagulation
type: Pathway
pathway order: PathwayEnzymeReaction/2118966
pathway order: PathwayEnzymeReaction/2118965
pathway order: PathwayEnzymeReaction/2118968
pathway order: PathwayEnzymeReaction/2118967
pathway order: PathwayEnzymeReaction/2118962
pathway order: PathwayEnzymeReaction/2118961
pathway order: PathwayEnzymeReaction/2118964
pathway order: PathwayEnzymeReaction/2118963
pathway order: PathwaySubPathway/109318
pathway order: PathwaySubPathway/109317
pathway order: PathwayTransport/2118972
pathway order: PathwayEnzymeReaction/2118959
pathway order: PathwaySubPathway/109314
pathway order: PathwayEnzymeReaction/2118958
pathway order: PathwayEnzymeReaction/2118969
pathway order: PathwaySubPathway/109316
pathway order: PathwaySubPathway/109315
pathway order: PathwayEnzymeReaction/2118960
pathway order: PathwayEnzymeReaction/2118971
pathway order: PathwayEnzymeReaction/2118970
pathway component: ReactionCatalysis168914
pathway component: ReactionCatalysis168913
pathway component: ReactionCatalysis168912
pathway component: ReactionCatalysis168911
pathway component: 3.4.21.38
pathway component: ReactionCatalysis168910
pathway component: Transport10104
pathway component: 3.4.21.5
pathway component: SubPathwayControl109317
pathway component: 3.4.21.22
pathway component: SubPathwayControl109318
pathway component: 3.4.21.27
pathway component: ReactionCatalysis168909
pathway component: SubPathwayControl109314
pathway component: SubPathwayControl109315
pathway component: SubPathwayControl109316
pathway component: 2.3.2.13
pathway component: Reaction178840
pathway component: 1.1.4.1
pathway component: ReactionCatalysis168922
pathway component: 4.1.1.90
pathway component: ReactionCatalysis168921
pathway component: 3.4.21.7
pathway component: ReactionCatalysis168920
pathway component: 3.4.21.68
pathway component: ReactionCatalysis168919
pathway component: ReactionCatalysis168918
pathway component: ReactionCatalysis168917
pathway component: ReactionCatalysis168916
xref: Reference/SMPDB SMP0119377
xref: Reference/PathWhiz PW120600
organism: Bos taurus

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11664 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11665 Extracellular Space/Stoichiometry/1.0
right: Fibrin (loose)
spontaneous: false
EC number: 3.4.21.5
left: Fibrinogen
name: Fibrinogen → Fibrin (loose)
conversion direction: LEFT_TO_RIGHT

2.3.2.13
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11665 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11666 Extracellular Space/Stoichiometry/1.0
right: Fibrin (mesh)
spontaneous: false
EC number: 2.3.2.13
left: Fibrin (loose)
name: Fibrin (loose) → Fibrin (mesh)
conversion direction: LEFT_TO_RIGHT

Reaction178840
type: BiochemicalReaction
participant stoichiometry: Protein/16197 Extracellular Space/Stoichiometry/1.0
right: Prothrombin
spontaneous: false
left: Prothrombin
name: Prothrombin → Thrombin
conversion direction: LEFT_TO_RIGHT

Complement factor H
type: Protein
cellular location: Extracellular Space
entity reference: Complement factor H

1.1.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002089/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001746/Stoichiometry/1.0
right: Reduced Vitamin K (phylloquinone)
spontaneous: false
EC number: 1.1.4.1
left: Vitamin K1 2,3-epoxide
name: Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone)
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 91577
type: UnificationXref
id: 91577
db: PubChem-compound

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002089/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001746/Stoichiometry/1.0
right: Vitamin K1 2,3-epoxide
spontaneous: false
EC number: 4.1.1.90
left: Reduced Vitamin K (phylloquinone)
name: Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide
conversion direction: LEFT_TO_RIGHT

3.4.21.7
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11666 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11667 Extracellular Space/Stoichiometry/1.0
right: Fibrin degradation products
spontaneous: false
EC number: 3.4.21.7
left: Fibrin (mesh)
name: Fibrin (mesh) → Fibrin degradation products
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q2KJG9
type: UnificationXref
id: Q2KJG9
db: UniProt

3.4.21.68
type: BiochemicalReaction
participant stoichiometry: Protein/7764 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/20391 Extracellular Space/Stoichiometry/1.0
right: Plasminogen
spontaneous: false
EC number: 3.4.21.68
left: Unknown
name: Plasminogen → Plasmin
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001746
type: ChemicalStructure
structure format: SMILES

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: ProteinReference
xref: Reference/UniProt P00734
organism: Bos taurus

Prothrombin and coagulation factors VII, IX and X
type: ProteinReference
xref: Reference/UniProt P00734
organism: Bos taurus

Reference/PathWhiz PW120600
type: UnificationXref
id: PW120600
db: PathWhiz

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/UniProt Q0P5I3
type: UnificationXref
id: Q0P5I3
db: UniProt

Coagulation factor X
type: Protein
entity reference: Coagulation factor X

Plasma kallikrein
type: Protein
cellular location: Extracellular Space
entity reference: Plasma kallikrein
name: SubPathwayActivator

Vitamin K epoxide reductase complex subunit 1
type: ProteinReference
xref: Reference/UniProt A2VDX1

Coagulation factor VII
type: Protein
entity reference: Coagulation factor VII
name: SubPathwayActivator

Tissue factor
type: Protein
entity reference: Tissue factor
name: SubPathwayActivator

Reference/CAS 25486-55-9
type: UnificationXref
id: 25486-55-9
db: CAS

Prothrombin
type: ProteinReference
xref: Reference/UniProt Q3MHK7
organism: Bos taurus

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Protein/Generic45 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/Generic44 Extracellular Space/Stoichiometry/1.0
right: Prothrombin and coagulation factors VII, IX and X
spontaneous: false
EC number: 4.1.1.90
left: Precursors of Prothrombin and coagulation factors VII, IX, ad X
name: Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X
conversion direction: LEFT_TO_RIGHT

Coagulation factor IX
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor IX

Reference/UniProt P12799
type: UnificationXref
id: P12799
db: UniProt

Reference/UniProt Q07175
type: UnificationXref
id: Q07175
db: UniProt

Reference/UniProt Q3T049
type: UnificationXref
id: Q3T049
db: UniProt

Coagulation factor XII
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XII
name: SubPathwayActivation
name: SubPathwayActivator

Collagen alpha-1(I) chain
type: ProteinReference
xref: Reference/UniProt Q3MHM2
organism: Bos taurus

ProteinComplex/11664 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrinogen
stoichiometric coefficient: 1.0

Reference/UniProt Q58DL3
type: UnificationXref
id: Q58DL3
db: UniProt

Reference/UniProt Q2KJ63
type: UnificationXref
id: Q2KJ63
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Protein/20391 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Plasminogen
stoichiometric coefficient: 1.0

Transport10104
type: Transport
participant stoichiometry: Protein/Generic45/Stoichiometry/1.0
right: Prothrombin and coagulation factors VII, IX and X
spontaneous: false
left: Prothrombin and coagulation factors VII, IX and X
name: Prothrombin and coagulation factors VII, IX and X (→) Transport: Bos taurus, Liver, Cell to Bos taurus, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Coagulation factor XIIIa
type: Complex
component: Protein-glutamine gamma-glutamyltransferase E
component: Complement factor H
name: SubPathwayActivation

Coagulation factor XI
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XI

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Coagulation factor XII
type: ProteinReference
xref: Reference/UniProt Q0P5I3

Protein/Generic45 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin and coagulation factors VII, IX and X
stoichiometric coefficient: 1.0

Plasma kallikrein
type: Protein
entity reference: Plasma kallikrein
name: SubPathwayActivation

Reference/UniProt Q5NTB3
type: UnificationXref
id: Q5NTB3
db: UniProt

Coagulation factor XI
type: Protein
entity reference: Coagulation factor XI

Fibrinogen alpha chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen alpha chain

Reference/UniProt P00734
type: UnificationXref
id: P00734
db: UniProt

BiologicalState416
type: BioSource
xref: Reference/TAXONOMY 9913
name: Bos taurus, Blood Vessel
tissue: Blood Vessel

ReactionCatalysis168922
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

ReactionCatalysis168921
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

ReactionCatalysis168920
type: Catalysis
controller: Vitamin K epoxide reductase complex subunit 1
controlled: 1.1.4.1
control type: ACTIVATION

Tissue factor:Coagulation factor VIIa
type: Complex
component: Coagulation factor VII
component: Tissue factor
name: SubPathwayActivation

Prothrombin
type: Protein
cellular location: Extracellular Space
entity reference: Prothrombin

Coagulation factor XI
type: ProteinReference
xref: Reference/UniProt Q5NTB3

Unknown
type: ProteinReference
organism: Bos taurus

Reference/ChEBI CHEBI 18067
type: UnificationXref
id: CHEBI:18067
db: ChEBI

Reduced Vitamin K (phylloquinone)
type: SmallMolecule
entity reference: Reduced Vitamin K (phylloquinone)

Reduced Vitamin K (phylloquinone)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5284607
xref: Reference/ChemSpider 4447652
xref: Reference/HMDB HMDB0004198
xref: Reference/KEGG Compound C05850
xref: Reference/ChEBI CHEBI 18067
xref: Reference/CAS 84-80-0
chemical formula: C31H46O2
molecular weight: 450.3498
structure: ChemicalStructure/PW C002089

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Protein/20360 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor IX
stoichiometric coefficient: 1.0

Coagulation factor V
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor V

Plasma kallikrein
type: ProteinReference
xref: Reference/UniProt Q2KJ63
organism: Bos taurus

Compound/PW C001746/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vitamin K1 2,3-epoxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28371
type: UnificationXref
id: CHEBI:28371
db: ChEBI

Coagulation factor XII
type: Protein
entity reference: Coagulation factor XII

Reference/UniProt P00743
type: UnificationXref
id: P00743
db: UniProt

ReactionCatalysis168919
type: Catalysis
controller: Tissue-type plasminogen activator
controlled: 3.4.21.68
control type: ACTIVATION

Reference/UniProt Q9TQZ7
type: UnificationXref
id: Q9TQZ7
db: UniProt

ReactionCatalysis168918
type: Catalysis
controller: Plasminogen
controlled: 3.4.21.7
control type: ACTIVATION

ReactionCatalysis168917
type: Catalysis
controller: Coagulation factor XIIIa
controlled: 2.3.2.13
control type: ACTIVATION

ReactionCatalysis168916
type: Catalysis
controller: Prothrombin
controlled: 3.4.21.5
control type: ACTIVATION