Coagulation factor X
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor X

Compound/PW C002089/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced Vitamin K (phylloquinone)
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05849
type: UnificationXref
id: C05849
db: KEGG Compound

Tissue factor
type: ProteinReference
xref: Reference/UniProt P42533

Coagulation factor X
type: ProteinReference
xref: Reference/UniProt Q63207
organism: Rattus norvegicus

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Protein/16198 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5284607
type: UnificationXref
id: 5284607
db: PubChem-compound

Unknown
type: Protein
cellular location: Extracellular Space
entity reference: Unknown

Hephaestin
type: ProteinReference
xref: Reference/UniProt Q920H8
organism: Rattus norvegicus

Reference/ChemSpider 82688
type: UnificationXref
id: 82688
db: ChemSpider

Reference/ChemSpider 4447652
type: UnificationXref
id: 4447652
db: ChemSpider

Fibrinogen gamma chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen gamma chain

ProteinComplex/11746 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin degradation products
stoichiometric coefficient: 1.0

Fibrinogen gamma chain
type: ProteinReference
xref: Reference/UniProt Q68FY3
organism: Rattus norvegicus

Protein/20368/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor X
stoichiometric coefficient: 1.0

Fibrinogen beta chain
type: ProteinReference
xref: Reference/UniProt Q7TME5
organism: Rattus norvegicus

Reference/UniProt Q7TME5
type: UnificationXref
id: Q7TME5
db: UniProt

Reference/KEGG Compound C05850
type: UnificationXref
id: C05850
db: KEGG Compound

Fibrinogen alpha chain
type: ProteinReference
xref: Reference/UniProt P06399
organism: Rattus norvegicus

Prothrombin and coagulation factors VII, IX and X
type: Protein
entity reference: Prothrombin and coagulation factors VII, IX and X

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Protein/20359 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor IX
stoichiometric coefficient: 1.0

Collagen alpha-1(I) chain
type: Protein
cellular location: Extracellular Space
entity reference: Collagen alpha-1(I) chain
name: SubPathwayActivator

Vitamin K epoxide reductase complex subunit 1
type: Protein
entity reference: Vitamin K epoxide reductase complex subunit 1

ChemicalStructure/PW C002089
type: ChemicalStructure
structure format: SMILES

Protein/Generic45/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin and coagulation factors VII, IX and X
stoichiometric coefficient: 1.0

Reference/UniProt Q920H8
type: UnificationXref
id: Q920H8
db: UniProt

Tenase complex
type: Complex
cellular location: Extracellular Space
component: Coagulation factor IX
component: Hephaestin

Coagulation factor XIII A chain
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIII A chain

Reference/SMPDB SMP0119394
type: UnificationXref
id: SMP0119394
db: SMPDB

Coagulation
type: Pathway
pathway order: PathwaySubPathway/109345
pathway order: PathwaySubPathway/109344
pathway order: PathwayEnzymeReaction/2119039
pathway order: PathwayEnzymeReaction/2119049
pathway order: PathwaySubPathway/109347
pathway order: PathwaySubPathway/109346
pathway order: PathwaySubPathway/109348
pathway order: PathwayEnzymeReaction/2119040
pathway order: PathwayEnzymeReaction/2119051
pathway order: PathwayTransport/2119053
pathway order: PathwayEnzymeReaction/2119050
pathway order: PathwayEnzymeReaction/2119046
pathway order: PathwayEnzymeReaction/2119045
pathway order: PathwayEnzymeReaction/2119048
pathway order: PathwayEnzymeReaction/2119047
pathway order: PathwayEnzymeReaction/2119042
pathway order: PathwayEnzymeReaction/2119041
pathway order: PathwayEnzymeReaction/2119052
pathway order: PathwayEnzymeReaction/2119044
pathway order: PathwayEnzymeReaction/2119043
pathway component: 3.4.21.38
pathway component: ReactionCatalysis168937
pathway component: 3.4.21.27
pathway component: ReactionCatalysis168936
pathway component: ReactionCatalysis168935
pathway component: ReactionCatalysis168934
pathway component: 3.4.21.22
pathway component: Reaction178857
pathway component: ReactionCatalysis168932
pathway component: 3.4.21.5
pathway component: ReactionCatalysis168931
pathway component: ReactionCatalysis168930
pathway component: 2.3.2.13
pathway component: ReactionCatalysis168929
pathway component: ReactionCatalysis168928
pathway component: ReactionCatalysis168927
pathway component: 4.1.1.90
pathway component: 3.4.21.68
pathway component: 1.1.4.1
pathway component: ReactionCatalysis168940
pathway component: Transport10138
pathway component: 3.4.21.7
pathway component: SubPathwayControl109344
pathway component: SubPathwayControl109345
pathway component: SubPathwayControl109346
pathway component: SubPathwayControl109347
pathway component: ReactionCatalysis168939
pathway component: SubPathwayControl109348
pathway component: ReactionCatalysis168938
xref: Reference/PathWhiz PW120617
xref: Reference/SMPDB SMP0119394
organism: Rattus norvegicus

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Fibrinogen
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen gamma chain
component: Fibrinogen beta chain

Coagulation factor XIIIa
type: Complex
component: Coagulation factor XIII A chain
component: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
name: SubPathwayActivation

Reference/PathWhiz PW120617
type: UnificationXref
id: PW120617
db: PathWhiz

Protein/20353/Stoichiometry/1.0
type: Stoichiometry
physical entity: Plasma kallikrein
stoichiometric coefficient: 1.0

Reference/UniProt Q68FY3
type: UnificationXref
id: Q68FY3
db: UniProt

Coagulation factor XIII A chain
type: ProteinReference
xref: Reference/UniProt O08619
organism: Rattus norvegicus

Reference/HMDB HMDB0002972
type: UnificationXref
id: HMDB0002972
db: HMDB

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
type: ProteinReference
xref: Reference/UniProt P0C6B8
organism: Rattus norvegicus

Reference/UniProt P42533
type: UnificationXref
id: P42533
db: UniProt

Reference/UniProt P18292
type: UnificationXref
id: P18292
db: UniProt

Reference/HMDB HMDB0004198
type: UnificationXref
id: HMDB0004198
db: HMDB

Vitamin K-dependent gamma-carboxylase
type: ProteinReference
xref: Reference/UniProt O88496

Coagulation factor VII
type: Protein
entity reference: Coagulation factor VII
name: SubPathwayActivator

Fibrinogen beta chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen beta chain

Tissue factor:Coagulation factor VIIa
type: Complex
component: Tissue factor
component: Coagulation factor VII
name: SubPathwayActivation

Reference/UniProt O08619
type: UnificationXref
id: O08619
db: UniProt

Plasminogen
type: Protein
cellular location: Extracellular Space
entity reference: Plasminogen

Coagulation factor XIIIa
type: Complex
cellular location: Extracellular Space
component: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
component: Coagulation factor XIII A chain

Transport10138
type: Transport
participant stoichiometry: Protein/Generic45/Stoichiometry/1.0
right: Prothrombin and coagulation factors VII, IX and X
spontaneous: false
left: Prothrombin and coagulation factors VII, IX and X
name: Prothrombin and coagulation factors VII, IX and X (→) Transport: Rattus norvegicus, Liver, Cell to Rattus norvegicus, Blood Vessel
conversion direction: LEFT_TO_RIGHT

BiologicalState452
type: BioSource
xref: Reference/TAXONOMY 10116
name: Rattus norvegicus, Blood Vessel
tissue: Blood Vessel

Reference/UniProt Q63207
type: UnificationXref
id: Q63207
db: UniProt

Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
type: UnificationXref
id: 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
db: BioCyc

Coagulation factor VII
type: ProteinReference
xref: Reference/UniProt Q8K3U6

Vitamin K1 2,3-epoxide
type: SmallMoleculeReference
xref: Reference/ChemSpider 82688
xref: Reference/HMDB HMDB0002972
xref: Reference/CAS 25486-55-9
xref: Reference/PubChem-compound 91577
xref: Reference/KEGG Compound C05849
xref: Reference/ChEBI CHEBI 28371
xref: Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
chemical formula: C31H46O3
molecular weight: 466.3447
structure: ChemicalStructure/PW C001746

ProteinComplex/11743 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrinogen
stoichiometric coefficient: 1.0

Vitamin K-dependent gamma-carboxylase
type: Protein
entity reference: Vitamin K-dependent gamma-carboxylase

Fibrin (loose)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen gamma chain
component: Fibrinogen beta chain

Reference/UniProt Q6TEK4
type: UnificationXref
id: Q6TEK4
db: UniProt

Coagulation factor IX
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor IX

Plasminogen
type: ProteinReference
xref: Reference/UniProt Q9R0W3
organism: Rattus norvegicus

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Tissue-type plasminogen activator
type: ProteinReference
xref: Reference/UniProt P19637
organism: Rattus norvegicus

Reference/UniProt O88496
type: UnificationXref
id: O88496
db: UniProt

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: Protein
cellular location: Extracellular Space
entity reference: Precursors of Prothrombin and coagulation factors VII, IX, ad X

Coagulation factor XIII A chain
type: Protein
entity reference: Coagulation factor XIII A chain
name: SubPathwayActivator

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
type: Protein
entity reference: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
name: SubPathwayActivator

3.4.21.38
type: BiochemicalReaction
participant stoichiometry: Protein/20353/Stoichiometry/1.0
right: Plasma kallikrein
spontaneous: false
EC number: 3.4.21.38
left: Plasma kallikrein
name: Coagulation factor XI → Coagulation factor XIa
conversion direction: LEFT_TO_RIGHT

3.4.21.27
type: BiochemicalReaction
participant stoichiometry: Protein/20359 Extracellular Space/Stoichiometry/1.0
right: Coagulation factor IX
spontaneous: false
EC number: 3.4.21.27
left: Coagulation factor IX
name: Coagulation factor IX → Coagulation factor IXa
conversion direction: LEFT_TO_RIGHT

3.4.21.22
type: BiochemicalReaction
participant stoichiometry: Protein/20368 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/20368/Stoichiometry/1.0
right: Coagulation factor X
spontaneous: false
EC number: 3.4.21.22
left: Coagulation factor X
name: Coagulation factor X → Coagulation factor Xa
conversion direction: LEFT_TO_RIGHT

Reaction178857
type: BiochemicalReaction
participant stoichiometry: Protein/16198 Extracellular Space/Stoichiometry/1.0
right: Prothrombin
spontaneous: false
left: Prothrombin
name: Prothrombin → Thrombin
conversion direction: LEFT_TO_RIGHT

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: Protein/20363 Extracellular Space/Stoichiometry/1.0
right: Hephaestin
spontaneous: false
EC number: 3.4.21.5
left: Hephaestin
name: Coagulation factor VIII → Coagulation factor VIIIa
conversion direction: LEFT_TO_RIGHT

Prothrombin and coagulation factors VII, IX and X
type: Protein
cellular location: Extracellular Space
entity reference: Prothrombin and coagulation factors VII, IX and X

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: Protein/20363 Extracellular Space/Stoichiometry/1.0
right: Hephaestin
spontaneous: false
EC number: 3.4.21.5
left: Hephaestin
name: Coagulation factor V → Coagulation factor Va
conversion direction: LEFT_TO_RIGHT

BiologicalState464
type: BioSource
xref: Reference/TAXONOMY 10116
name: Rattus norvegicus, Liver
tissue: Liver

Protein/20392 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Plasminogen
stoichiometric coefficient: 1.0

Vitamin K1 2,3-epoxide
type: SmallMolecule
entity reference: Vitamin K1 2,3-epoxide

Hephaestin
type: Protein
cellular location: Extracellular Space
entity reference: Hephaestin

Fibrin (mesh)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen gamma chain
component: Fibrinogen beta chain

Prothrombin
type: Protein
cellular location: Extracellular Space
entity reference: Prothrombin

Reference/CAS 84-80-0
type: UnificationXref
id: 84-80-0
db: CAS

Reference/UniProt P14272
type: UnificationXref
id: P14272
db: UniProt

Reference/UniProt F1M1M6
type: UnificationXref
id: F1M1M6
db: UniProt

Protein/Generic44 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Precursors of Prothrombin and coagulation factors VII, IX, ad X
stoichiometric coefficient: 1.0

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11744 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11743 Extracellular Space/Stoichiometry/1.0
right: Fibrin (loose)
spontaneous: false
EC number: 3.4.21.5
left: Fibrinogen
name: Fibrinogen → Fibrin (loose)
conversion direction: LEFT_TO_RIGHT

2.3.2.13
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11744 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11745 Extracellular Space/Stoichiometry/1.0
right: Fibrin (mesh)
spontaneous: false
EC number: 2.3.2.13
left: Fibrin (loose)
name: Fibrin (loose) → Fibrin (mesh)
conversion direction: LEFT_TO_RIGHT

ProteinComplex/11744 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (loose)
stoichiometric coefficient: 1.0

Reference/UniProt Q8K3U6
type: UnificationXref
id: Q8K3U6
db: UniProt

Reference/PubChem-compound 91577
type: UnificationXref
id: 91577
db: PubChem-compound

ChemicalStructure/PW C001746
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis168940
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

Tissue-type plasminogen activator
type: Protein
cellular location: Extracellular Space
entity reference: Tissue-type plasminogen activator

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: ProteinReference
xref: Reference/UniProt P00734
organism: Rattus norvegicus

Prothrombin and coagulation factors VII, IX and X
type: ProteinReference
xref: Reference/UniProt P00734
organism: Rattus norvegicus

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Coagulation factor XII
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XII
name: SubPathwayActivation
name: SubPathwayActivator

Tissue factor
type: Protein
entity reference: Tissue factor
name: SubPathwayActivator

Fibrin degradation products
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen gamma chain
component: Fibrinogen beta chain

Vitamin K epoxide reductase complex subunit 1
type: ProteinReference
xref: Reference/UniProt Q6TEK4

Coagulation factor X
type: Protein
entity reference: Coagulation factor X

Reference/CAS 25486-55-9
type: UnificationXref
id: 25486-55-9
db: CAS

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
type: Protein
cellular location: Extracellular Space
entity reference: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Prothrombin
type: ProteinReference
xref: Reference/UniProt P18292
organism: Rattus norvegicus

Protein/20363 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hephaestin
stoichiometric coefficient: 1.0

ReactionCatalysis168939
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

ReactionCatalysis168938
type: Catalysis
controller: Vitamin K epoxide reductase complex subunit 1
controlled: 1.1.4.1
control type: ACTIVATION

Reference/UniProt P06399
type: UnificationXref
id: P06399
db: UniProt

ReactionCatalysis168937
type: Catalysis
controller: Tissue-type plasminogen activator
controlled: 3.4.21.68
control type: ACTIVATION

ReactionCatalysis168936
type: Catalysis
controller: Plasminogen
controlled: 3.4.21.7
control type: ACTIVATION

Reference/UniProt Q63079
type: UnificationXref
id: Q63079
db: UniProt

ReactionCatalysis168935
type: Catalysis
controller: Coagulation factor XIIIa
controlled: 2.3.2.13
control type: ACTIVATION

ReactionCatalysis168934
type: Catalysis
controller: Prothrombin
controlled: 3.4.21.5
control type: ACTIVATION

Fibrinogen alpha chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen alpha chain

ReactionCatalysis168932
type: Catalysis
controller: Tissue factor:Coagulation factor VIIa
controlled: 3.4.21.22
control type: ACTIVATION

ReactionCatalysis168931
type: Catalysis
controller: Tenase complex
controlled: 3.4.21.22
control type: ACTIVATION

ReactionCatalysis168930
type: Catalysis
controller: Prothrombin
controlled: 3.4.21.5
control type: ACTIVATION

Unknown
type: ProteinReference
organism: Rattus norvegicus

Coagulation factor XIII A and B activate to Coagulation factor XIIIa
type: Pathway
name: ActivatingSubPathway

Activate Coagulatin factor VII to VIIa by binding to Tissue Factor
type: Pathway
name: ActivatingSubPathway

XII activated to XIIa by Plasma kallikrein
type: Pathway
name: ActivatingSubPathway

Plasma prekallikrein activated to Plasma kallikrein by XIIa
type: Pathway
name: ActivatingSubPathway

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

XII activated to XIIa by Collagen
type: Pathway
name: ActivatingSubPathway

Collagen alpha-1(I) chain
type: ProteinReference
xref: Reference/UniProt Q63079
organism: Rattus norvegicus

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Coagulation factor XII
type: ProteinReference
xref: Reference/UniProt Q5M879

Vitamin K-dependent gamma-carboxylase
type: Protein
cellular location: Extracellular Space
entity reference: Vitamin K-dependent gamma-carboxylase

Protein/Generic45 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin and coagulation factors VII, IX and X
stoichiometric coefficient: 1.0

ReactionCatalysis168929
type: Catalysis
controller: Prothrombin
controlled: 3.4.21.5
control type: ACTIVATION

Protein/7758 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

ReactionCatalysis168928
type: Catalysis
controller: Plasma kallikrein
controlled: 3.4.21.27
control type: ACTIVATION

Reference/UniProt P00734
type: UnificationXref
id: P00734
db: UniProt

ReactionCatalysis168927
type: Catalysis
controller: Coagulation factor XII
controlled: 3.4.21.38
control type: ACTIVATION

Plasma kallikrein
type: Protein
entity reference: Plasma kallikrein
name: SubPathwayActivation

Plasma kallikrein
type: Protein
cellular location: Extracellular Space
entity reference: Plasma kallikrein
name: SubPathwayActivator

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002089/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001746/Stoichiometry/1.0
right: Vitamin K1 2,3-epoxide
spontaneous: false
EC number: 4.1.1.90
left: Reduced Vitamin K (phylloquinone)
name: Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide
conversion direction: LEFT_TO_RIGHT

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Protein/Generic45 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/Generic44 Extracellular Space/Stoichiometry/1.0
right: Prothrombin and coagulation factors VII, IX and X
spontaneous: false
EC number: 4.1.1.90
left: Precursors of Prothrombin and coagulation factors VII, IX, ad X
name: Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X
conversion direction: LEFT_TO_RIGHT

3.4.21.68
type: BiochemicalReaction
participant stoichiometry: Protein/20392 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/7758 Extracellular Space/Stoichiometry/1.0
right: Plasminogen
spontaneous: false
EC number: 3.4.21.68
left: Unknown
name: Plasminogen → Plasmin
conversion direction: LEFT_TO_RIGHT

1.1.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002089/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001746/Stoichiometry/1.0
right: Reduced Vitamin K (phylloquinone)
spontaneous: false
EC number: 1.1.4.1
left: Vitamin K1 2,3-epoxide
name: Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone)
conversion direction: LEFT_TO_RIGHT

ProteinComplex/11745 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (mesh)
stoichiometric coefficient: 1.0

Reference/UniProt P0C6B8
type: UnificationXref
id: P0C6B8
db: UniProt

Reference/UniProt P19637
type: UnificationXref
id: P19637
db: UniProt

3.4.21.7
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11745 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11746 Extracellular Space/Stoichiometry/1.0
right: Fibrin degradation products
spontaneous: false
EC number: 3.4.21.7
left: Fibrin (mesh)
name: Fibrin (mesh) → Fibrin degradation products
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q5M879
type: UnificationXref
id: Q5M879
db: UniProt

Reference/ChEBI CHEBI 18067
type: UnificationXref
id: CHEBI:18067
db: ChEBI

Coagulation factor IX
type: ProteinReference
xref: Reference/UniProt F1M1M6
organism: Rattus norvegicus

Reduced Vitamin K (phylloquinone)
type: SmallMolecule
entity reference: Reduced Vitamin K (phylloquinone)

SubPathwayControl109344
type: Interaction
name: SubPathway109344Control
name: ActivatingSubPathwayControl
participant: Collagen alpha-1(I) chain
participant: XII activated to XIIa by Collagen
participant: Coagulation factor XII

Reduced Vitamin K (phylloquinone)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5284607
xref: Reference/ChemSpider 4447652
xref: Reference/HMDB HMDB0004198
xref: Reference/KEGG Compound C05850
xref: Reference/ChEBI CHEBI 18067
xref: Reference/CAS 84-80-0
chemical formula: C31H46O2
molecular weight: 450.3498
structure: ChemicalStructure/PW C002089

SubPathwayControl109345
type: Interaction
name: SubPathway109345Control
name: ActivatingSubPathwayControl
participant: Plasma kallikrein
participant: XII activated to XIIa by Plasma kallikrein
participant: Coagulation factor XII

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Protein/20368 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor X
stoichiometric coefficient: 1.0

Plasma kallikrein
type: ProteinReference
xref: Reference/UniProt P14272

Compound/PW C001746/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vitamin K1 2,3-epoxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28371
type: UnificationXref
id: CHEBI:28371
db: ChEBI

Reference/UniProt Q9R0W3
type: UnificationXref
id: Q9R0W3
db: UniProt

SubPathwayControl109346
type: Interaction
name: SubPathway109346Control
name: ActivatingSubPathwayControl
participant: Plasma kallikrein
participant: Plasma prekallikrein activated to Plasma kallikrein by XIIa
participant: Coagulation factor XII

SubPathwayControl109347
type: Interaction
name: SubPathway109347Control
name: ActivatingSubPathwayControl
participant: Coagulation factor XIIIa
participant: Coagulation factor XIII A and B activate to Coagulation factor XIIIa
participant: Coagulation factor XIII A chain
participant: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

SubPathwayControl109348
type: Interaction
name: SubPathway109348Control
name: ActivatingSubPathwayControl
participant: Tissue factor
participant: Tissue factor:Coagulation factor VIIa
participant: Activate Coagulatin factor VII to VIIa by binding to Tissue Factor
participant: Coagulation factor VII

Coagulation factor XII
type: Protein
entity reference: Coagulation factor XII