Reference/UniProt Q6UA68
type: UnificationXref
id: Q6UA68
db: UniProt

DG(14:0/14:1(9Z)/0:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: DG(14:0/14:1(9Z)/0:0)

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sodium/calcium exchanger 1
type: ProteinReference
xref: Reference/UniProt Q9WU30

Reference/UniProt P0DP31
type: UnificationXref
id: P0DP31
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19708/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Protein/20530 sarcoplasmic reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

ATP-binding cassette sub-family C member 9
type: ProteinReference
xref: Reference/UniProt O89115

direct_interaction
type: InteractionVocabulary

Protein/20640 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin T, fast skeletal muscle
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Potassium channel subfamily K member 1
type: ProteinReference
xref: Reference/UniProt Q9Z2T2

Reference/UniProt Q9EQT0
type: UnificationXref
id: Q9EQT0
db: UniProt

Reference/UniProt O89115
type: UnificationXref
id: O89115
db: UniProt

Disks large homolog 1
type: Protein
entity reference: Disks large homolog 1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt P10687
organism: BiologicalState574

TransportCatalysis1337
type: Catalysis
controller: Voltage-gated sodium channel (INa)
controlled: Transport10127
control type: ACTIVATION

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q62869

Reference/UniProt Q62696
type: UnificationXref
id: Q62696
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Protein/7758/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayActivator

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown
name: SubPathwayActivator

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Inward rectifier potassium channel (IK1)
type: Complex
component: Unknown

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: ProteinReference
xref: Reference/UniProt Q9QZW4

Reference/UniProt P63251
type: UnificationXref
id: P63251
db: UniProt

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha
name: SubPathwayActivation
name: SubPathwayActivator

3.6.3.8
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 sarcoplasmic reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 sarcoplasmic reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 sarcoplasmic reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 sarcoplasmic reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 sarcoplasmic reticulum/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: Calcium
spontaneous: false
EC number: 3.6.3.8
left: Water
left: Adenosine triphosphate
left: Calcium
name: Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
conversion direction: LEFT_TO_RIGHT

Potassium voltage-gated channel subfamily A member 5
type: Protein
entity reference: Potassium voltage-gated channel subfamily A member 5

Reference/UniProt P48548
type: UnificationXref
id: P48548
db: UniProt

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Voltage-gated sodium channel (INa)
type: Complex
component: Unknown

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/7758/Stoichiometry/1.0
component: Unknown

Muscle/Heart Contraction
type: Pathway
pathway order: PathwaySubPathway/109349
pathway order: PathwayTransport/2119066
pathway order: PathwayTransport/2119065
pathway order: PathwayTransport/2119064
pathway order: PathwayTransport/2119063
pathway order: PathwayTransport/2119069
pathway order: PathwayTransport/2119068
pathway order: PathwayTransport/2119067
pathway order: PathwayInteraction/1167
pathway order: PathwayTransport/2119062
pathway order: PathwayTransport/2119061
pathway order: PathwayEnzymeReaction/2119055
pathway order: PathwayTransport/2119060
pathway order: PathwayEnzymeReaction/2119054
pathway order: PathwaySubPathway/109354
pathway order: PathwaySubPathway/109353
pathway order: PathwaySubPathway/109356
pathway order: PathwaySubPathway/109355
pathway order: PathwaySubPathway/109350
pathway order: PathwaySubPathway/109352
pathway order: PathwaySubPathway/109351
pathway order: PathwaySubPathway/109358
pathway order: PathwaySubPathway/109357
pathway order: PathwayTransport/2119059
pathway order: PathwayTransport/2119058
pathway order: PathwayTransport/2119057
pathway order: PathwayTransport/2119056
pathway order: PathwayTransport/2119071
pathway order: PathwayTransport/2119070
pathway component: TransportCatalysis1363
pathway component: Transport10127
pathway component: Interaction1167
pathway component: Transport10141
pathway component: SubPathwayControl109353
pathway component: Transport10120
pathway component: Transport10142
pathway component: SubPathwayControl109354
pathway component: Transport10143
pathway component: SubPathwayControl109355
pathway component: Transport10144
pathway component: SubPathwayControl109356
pathway component: SubPathwayControl109350
pathway component: SubPathwayControl109351
pathway component: Transport10140
pathway component: SubPathwayControl109352
pathway component: TransportCatalysis1360
pathway component: TransportCatalysis1362
pathway component: TransportCatalysis1361
pathway component: SubPathwayControl109357
pathway component: SubPathwayControl109358
pathway component: TransportCatalysis1357
pathway component: TransportCatalysis1356
pathway component: TransportCatalysis1359
pathway component: TransportCatalysis1337
pathway component: TransportCatalysis1358
pathway component: TransportCatalysis1353
pathway component: TransportCatalysis1352
pathway component: 3.1.4.11
pathway component: TransportCatalysis1355
pathway component: ReactionCatalysis168941
pathway component: TransportCatalysis1354
pathway component: Transport10139
pathway component: ReactionCoupledTransportCatalysis461
pathway component: 3.6.3.8
pathway component: TransportCatalysis1351
pathway component: TransportCatalysis1350
pathway component: SubPathwayControl109349
xref: Reference/PathWhiz PW120618
xref: Reference/SMPDB SMP0119395
organism: Rattus norvegicus

Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
type: Complex
component: Unknown

Voltage-gated slow delayed rectifying potassium channel (IK5)
type: Complex
component: Unknown

Reference/ChemSpider 24765843
type: UnificationXref
id: 24765843
db: ChemSpider

Voltage-gated rapid delayed rectifying potassium channel (IKr)
type: Complex
component: Unknown

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PathWhiz PW120618
type: UnificationXref
id: PW120618
db: PathWhiz

Protein/20537 sarcoplasmic reticulum/Stoichiometry/5.0
type: Stoichiometry
physical entity: Cardiac phospholamban
stoichiometric coefficient: 5.0

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

G protein-activated inward rectifier potassium channel 4
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 4

Transport10141
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cardiomyocyte , Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Transport10142
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 sarcoplasmic reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Rattus norvegicus, Cardiomyocyte , sarcoplasmic reticulum to Rattus norvegicus, Cardiomyocyte , Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10143
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cardiomyocyte , Cytosol
conversion direction: LEFT_TO_RIGHT

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Transport10144
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Rattus norvegicus, Cell, Endoplasmic Reticulum to Rattus norvegicus, Cardiomyocyte , Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10140
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
right: Sodium
spontaneous: false
left: Sodium
left: Calcium
name: Calcium (→), Sodium (←) Transport: Rattus norvegicus, Cardiomyocyte , Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Troponin T, cardiac muscle
type: Protein
cellular location: Cytosol
entity reference: Troponin T, cardiac muscle

G protein-activated inward rectifier potassium channel 1
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 1

Reference/UniProt Q9WU30
type: UnificationXref
id: Q9WU30
db: UniProt

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

TransportCatalysis1357
type: Catalysis
controller: Potassium channel subfamily K member 1
controlled: Transport10139
control type: ACTIVATION

TransportCatalysis1356
type: Catalysis
controller: ATP-sensitive inward rectifier potassium channel (IKATP)
controlled: Transport10139
control type: ACTIVATION

TransportCatalysis1359
type: Catalysis
controller: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
controlled: Transport10141
control type: ACTIVATION

TransportCatalysis1358
type: Catalysis
controller: Sodium/calcium exchanger 1
controlled: Transport10140
control type: ACTIVATION

Cardiac phospholamban
type: Complex
component stoichiometry: Protein/20537 sarcoplasmic reticulum/Stoichiometry/5.0
cellular location: sarcoplasmic reticulum
component: Cardiac phospholamban
name: SubPathwayInhibitor

TransportCatalysis1353
type: Catalysis
controller: Voltage-gated ultra rapid delayed rectifying potassium channel
controlled: Transport10139
control type: ACTIVATION

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

TransportCatalysis1352
type: Catalysis
controller: Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
controlled: Transport10139
control type: ACTIVATION

TransportCatalysis1355
type: Catalysis
controller: Voltage-gated rapid delayed rectifying potassium channel (IKr)
controlled: Transport10139
control type: ACTIVATION

TransportCatalysis1354
type: Catalysis
controller: Voltage-gated slow delayed rectifying potassium channel (IK5)
controlled: Transport10139
control type: ACTIVATION

BiologicalState574
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 10116
name: Rattus norvegicus, Cardiomyocyte

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Transport10139
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Rattus norvegicus, Cardiomyocyte , Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/CELL TYPE ONTOLOGY CL 0000746
type: UnificationXref
id: CL:0000746
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

TransportCatalysis1351
type: Catalysis
controller: Acetylcholine-activated potassium channel (IKACh)
controlled: Transport10139
control type: ACTIVATION

TransportCatalysis1350
type: Catalysis
controller: Inward rectifier potassium channel (IK1)
controlled: Transport10139
control type: ACTIVATION

Reference/ChemSpider 24767919
type: UnificationXref
id: 24767919
db: ChemSpider

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Reference/UniProt Q9Z2T2
type: UnificationXref
id: Q9Z2T2
db: UniProt

Troponin, fast skeletal muscle
type: Complex
component stoichiometry: Protein/20627 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/20640 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19864 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calmodulin-3
component: Troponin T, fast skeletal muscle
component: Troponin I, fast skeletal muscle
name: SubPathwayActivation

Transport10127
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Troponin I, slow skeletal muscle
type: ProteinReference
xref: Reference/UniProt P13413
organism: BiologicalState574

Potassium voltage-gated channel subfamily A member 5
type: ProteinReference
xref: Reference/UniProt Q6LEB7

SubPathwayControl109353
type: Interaction
name: SubPathway109353Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Ryanodine receptor 2

Transport10120
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

SubPathwayControl109354
type: Interaction
name: SubPathway109354Control
name: ActivatingSubPathwayControl
participant: Calmodulin-3
participant: Myosin light chain kinase 2, skeletal/cardiac muscle
participant: Calcium
participant: Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
name: SubPathwayInhibition

SubPathwayControl109355
type: Interaction
name: SubPathway109355Control
name: ActivatingSubPathwayControl
participant: Myosin light chain kinase 2, skeletal/cardiac muscle
participant: Muscle Contraction

SubPathwayControl109356
type: Interaction
name: SubPathway109356Control
name: ActivatingSubPathwayControl
participant: Ryanodine receptor 2
participant: Calcium
participant: Calcium activates Ryanodine receptor 2

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

SubPathwayControl109350
type: Interaction
name: SubPathway109350Control
name: InhibitorySubPathwayControl
participant: Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
participant: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
participant: Cardiac phospholamban

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/20530 sarcoplasmic reticulum/Stoichiometry/4.0
cellular location: sarcoplasmic reticulum
component: Ryanodine receptor 2
name: SubPathwayActivation

SubPathwayControl109351
type: Interaction
name: SubPathway109351Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase type I-alpha regulatory subunit
participant: G-protein signalling cascade
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Unknown

sarcoplasmic reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

SubPathwayControl109352
type: Interaction
name: SubPathway109352Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Voltage-depenent L-type calcium channel

Adenosine diphosphate
type: SmallMolecule
cellular location: sarcoplasmic reticulum
entity reference: Adenosine diphosphate

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/PubChem-compound 53480233
type: UnificationXref
id: 53480233
db: PubChem-compound

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

SubPathwayControl109357
type: Interaction
name: SubPathway109357Control
name: ActivatingSubPathwayControl
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: Unknown
participant: G-protein signalling cascade

SubPathwayControl109358
type: Interaction
name: SubPathway109358Control
name: ActivatingSubPathwayControl
participant: Troponin, fast skeletal muscle
participant: Calcium activates Troponin
participant: Calcium
participant: Troponin, slow skeletal muscle
participant: Tropomyosin
participant: Troponin, cardiac muscle

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/20530/Stoichiometry/4.0
component: Ryanodine receptor 2

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

ReactionCatalysis168941
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: 3.1.4.11
control type: ACTIVATION

Compound/PW C000353 sarcoplasmic reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Acetylcholine-activated potassium channel (IKACh)
type: Complex
component: G protein-activated inward rectifier potassium channel 4
component: G protein-activated inward rectifier potassium channel 1
name: SubPathwayActivation

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Protein/20668 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin beta chain
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Disks large homolog 1
type: ProteinReference
xref: Reference/UniProt Q62696

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Protein/20652 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin alpha-1 chain
stoichiometric coefficient: 1.0

Protein/20564 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin I, slow skeletal muscle
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: sarcoplasmic reticulum
entity reference: Calcium

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

Voltage-gated ultra rapid delayed rectifying potassium channel
type: Complex
component: Potassium voltage-gated channel subfamily A member 5
component: Disks large homolog 1

ATP-sensitive inward rectifier potassium channel (IKATP)
type: Complex
component: ATP-sensitive inward rectifier potassium channel 11
component: ATP-sensitive inward rectifier potassium channel 8
component: ATP-binding cassette sub-family C member 9
component: ATP-binding cassette sub-family C member 8

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Troponin T, slow skeletal muscle
type: ProteinReference
xref: Reference/UniProt Q923S7
organism: BiologicalState574

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Troponin I, cardiac muscle
type: Protein
cellular location: Cytosol
entity reference: Troponin I, cardiac muscle

ChemicalStructure/PW C003060
type: ChemicalStructure
structure format: SMILES

Compound/PW C001420 sarcoplasmic reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C006083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/20:3(8Z,11Z,14Z))
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0010042
type: UnificationXref
id: HMDB0010042
db: HMDB

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/UniProt P61016
type: UnificationXref
id: P61016
db: UniProt

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003060 Cytosol/Stoichiometry/1.0
right: DG(14:0/14:1(9Z)/0:0)
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: PIP2(16:0/20:3(8Z,11Z,14Z))
name: PIP2(16:0/20:3(8Z,11Z,14Z)) → DG(14:0/14:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

ATP-sensitive inward rectifier potassium channel 11
type: ProteinReference
xref: Reference/UniProt Q9JM48

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

ATP-sensitive inward rectifier potassium channel 8
type: ProteinReference
xref: Reference/UniProt Q9JM50

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/UniProt P13413
type: UnificationXref
id: P13413
db: UniProt

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/UniProt Q548R1
type: UnificationXref
id: Q548R1
db: UniProt

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

ATP-binding cassette sub-family C member 8
type: ProteinReference
xref: Reference/UniProt Q9EQT0

Reference/UniProt D7UNT3
type: UnificationXref
id: D7UNT3
db: UniProt

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

SubPathwayControl109349
type: Interaction
name: SubPathway109349Control
name: ActivatingSubPathwayControl
participant: Acetylcholine-activated potassium channel (IKACh)
participant: G-protein signalling cascade
participant: Muscarinic acetylcholine receptor M2

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

Protein/20627 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin I, fast skeletal muscle
stoichiometric coefficient: 1.0

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
name: SubPathwayActivation

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Troponin, slow skeletal muscle
type: Complex
component stoichiometry: Protein/20580 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/20564 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19864 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Troponin I, slow skeletal muscle
component: Calmodulin-3
component: Troponin T, slow skeletal muscle
name: SubPathwayActivation

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
cellular location: sarcoplasmic reticulum
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Interaction1167
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: Reference/UniProt Q9Z2Z1
organism: BiologicalState574

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Protein/20530/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Protein/20580 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin T, slow skeletal muscle
stoichiometric coefficient: 1.0

Troponin T, fast skeletal muscle
type: ProteinReference
xref: Reference/UniProt Q4PPA0
organism: BiologicalState574

Reference/UniProt Q9JM48
type: UnificationXref
id: Q9JM48
db: UniProt

Reference/UniProt Q4PP23
type: UnificationXref
id: Q4PP23
db: UniProt

Reference/PubChem-compound 53477948
type: UnificationXref
id: 53477948
db: PubChem-compound

PIP2(16:0/20:3(8Z,11Z,14Z))
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP2(16:0/20:3(8Z,11Z,14Z))

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Troponin T, fast skeletal muscle
type: Protein
cellular location: Cytosol
entity reference: Troponin T, fast skeletal muscle

Compound/PW C001104 sarcoplasmic reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Myosin light chain kinase 2, skeletal/cardiac muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase 2, skeletal/cardiac muscle
name: SubPathwayActivation
name: SubPathwayActivator

Reference/UniProt P10687
type: UnificationXref
id: P10687
db: UniProt

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Reference/UniProt P09456
type: UnificationXref
id: P09456
db: UniProt

Reference/KEGG Compound C00165
type: UnificationXref
id: C00165
db: KEGG Compound

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: ProteinReference
xref: Reference/UniProt P11508
organism: BiologicalState574

ReactionCoupledTransportCatalysis461
type: Catalysis
controller: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
controlled: 3.6.3.8
control type: ACTIVATION

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Unknown
type: Protein
entity reference: Unknown

Tropomyosin alpha-1 chain
type: ProteinReference
xref: Reference/UniProt Q63609
organism: BiologicalState574

Cardiac phospholamban
type: ProteinReference
xref: Reference/UniProt P61016
organism: BiologicalState574

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Protein/19708/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt D7UNT3

Protein/19708 Endoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Reference/SMPDB SMP0119395
type: UnificationXref
id: SMP0119395
db: SMPDB

Reference/UniProt Q9JM50
type: UnificationXref
id: Q9JM50
db: UniProt

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Phosphate
type: SmallMolecule
cellular location: sarcoplasmic reticulum
entity reference: Phosphate

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Tropomyosin beta chain
type: ProteinReference
xref: Reference/UniProt P06395
organism: BiologicalState574

Reference/UniProt Q62869
type: UnificationXref
id: Q62869
db: UniProt

Tropomyosin beta chain
type: Protein
cellular location: Cytosol
entity reference: Tropomyosin beta chain

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: Reference/UniProt P20689
organism: BiologicalState574

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19708 Endoplasmic Reticulum/Stoichiometry/4.0
cellular location: Endoplasmic Reticulum
component: Inositol 1,4,5-trisphosphate receptor type 1

Reference/UniProt Q6LEB7
type: UnificationXref
id: Q6LEB7
db: UniProt

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48548

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt Q548R1

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: Reference/UniProt P63251

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Inositol 1,4,5-trisphosphate

Reference/UniProt Q63609
type: UnificationXref
id: Q63609
db: UniProt

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C003060 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(14:0/14:1(9Z)/0:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
name: SubPathwayActivation

Calmodulin-3
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-3
name: SubPathwayActivator

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt Q9EQ60

PIP2(16:0/20:3(8Z,11Z,14Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010042
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/PubChem-compound 53480233
xref: Reference/ChemSpider 24767919
chemical formula: C45H83O19P3
molecular weight: 1020.4741
structure: ChemicalStructure/PW C006083

Tropomyosin
type: Complex
component stoichiometry: Protein/20652 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/20668 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Tropomyosin beta chain
component: Tropomyosin alpha-1 chain
name: SubPathwayActivation

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

TransportCatalysis1363
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport10144
control type: ACTIVATION

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Troponin I, cardiac muscle
type: ProteinReference
xref: Reference/UniProt Q4PP23
organism: BiologicalState574

Protein/19864 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-3
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/UniProt P20689
type: UnificationXref
id: P20689
db: UniProt

Protein/20617 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin T, cardiac muscle
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0007009
type: UnificationXref
id: HMDB0007009
db: HMDB

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: Protein
entity reference: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

TransportCatalysis1360
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport10142
control type: ACTIVATION

Muscarinic acetylcholine receptor M2
type: Protein
cellular location: Cell Membrane
entity reference: Muscarinic acetylcholine receptor M2
name: SubPathwayActivator

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

DG(14:0/14:1(9Z)/0:0)
type: SmallMoleculeReference
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/HMDB HMDB0007009
xref: Reference/ChemSpider 24765843
xref: Reference/KEGG Compound C00165
xref: Reference/PubChem-compound 53477948
chemical formula: C31H58O5
molecular weight: 510.42844
structure: ChemicalStructure/PW C003060

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

TransportCatalysis1362
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport10143
control type: ACTIVATION

TransportCatalysis1361
type: Catalysis
controller: Voltage-depenent L-type calcium channel
controlled: Transport10143
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Tropomyosin alpha-1 chain
type: Protein
cellular location: Cytosol
entity reference: Tropomyosin alpha-1 chain

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Troponin T, cardiac muscle
type: ProteinReference
xref: Reference/UniProt P50753
organism: BiologicalState574

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/UniProt Q923S7
type: UnificationXref
id: Q923S7
db: UniProt

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Cardiac phospholamban
type: Protein
cellular location: sarcoplasmic reticulum
entity reference: Cardiac phospholamban

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Troponin T, slow skeletal muscle
type: Protein
cellular location: Cytosol
entity reference: Troponin T, slow skeletal muscle

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: sarcoplasmic reticulum
entity reference: Adenosine triphosphate

Reference/UniProt Q9QZW4
type: UnificationXref
id: Q9QZW4
db: UniProt

Sodium/calcium exchanger 1
type: Protein
entity reference: Sodium/calcium exchanger 1

ATP-binding cassette sub-family C member 9
type: Protein
entity reference: ATP-binding cassette sub-family C member 9

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP31
organism: BiologicalState574

Potassium channel subfamily K member 1
type: Protein
entity reference: Potassium channel subfamily K member 1

Troponin I, fast skeletal muscle
type: Protein
cellular location: Cytosol
entity reference: Troponin I, fast skeletal muscle

ChemicalStructure/PW C006083
type: ChemicalStructure
structure format: SMILES

Troponin I, fast skeletal muscle
type: ProteinReference
xref: Reference/UniProt P27768
organism: BiologicalState574

Unknown
type: ProteinReference

Water
type: SmallMolecule
cellular location: sarcoplasmic reticulum
entity reference: Water

G-protein signalling cascade
type: Pathway
name: ActivatingSubPathway

Reference/UniProt Q9Z2Z1
type: UnificationXref
id: Q9Z2Z1
db: UniProt

Reference/UniProt P11508
type: UnificationXref
id: P11508
db: UniProt

Reference/UniProt P06395
type: UnificationXref
id: P06395
db: UniProt

Ryanodine receptor 2
type: Protein
cellular location: sarcoplasmic reticulum
entity reference: Ryanodine receptor 2

Troponin, cardiac muscle
type: Complex
component stoichiometry: Protein/20617 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/20604 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19864 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calmodulin-3
component: Troponin T, cardiac muscle
component: Troponin I, cardiac muscle
name: SubPathwayActivation

ATP-sensitive inward rectifier potassium channel 11
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 11

cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
type: Pathway
name: ActivatingSubPathway

cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Pathway
name: InhibitorySubPathway

ATP-sensitive inward rectifier potassium channel 8
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 8

G-protein signalling cascade
type: Pathway
name: ActivatingSubPathway

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt P50753
type: UnificationXref
id: P50753
db: UniProt

ATP-binding cassette sub-family C member 8
type: Protein
entity reference: ATP-binding cassette sub-family C member 8

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P09456
organism: BiologicalState574

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt Q6UA68
organism: BiologicalState574

Troponin I, slow skeletal muscle
type: Protein
cellular location: Cytosol
entity reference: Troponin I, slow skeletal muscle

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Reference/UniProt Q4PPA0
type: UnificationXref
id: Q4PPA0
db: UniProt

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Calcium

Cardiomyocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000746

Compound/PW C000414 sarcoplasmic reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Calcium activates Troponin
type: Pathway
name: ActivatingSubPathway

Calcium activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

Protein/20604 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin I, cardiac muscle
stoichiometric coefficient: 1.0

Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

G-protein signalling cascade
type: Pathway
name: ActivatingSubPathway

Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle
type: Pathway
name: ActivatingSubPathway

Muscle Contraction
type: Pathway
name: ActivatingSubPathway

Protein/7758 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Compound/PW C001034 sarcoplasmic reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/7758 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Unknown
name: SubPathwayActivation

Reference/UniProt Q9EQ60
type: UnificationXref
id: Q9EQ60
db: UniProt

Reference/UniProt P27768
type: UnificationXref
id: P27768
db: UniProt

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0