112934
Pathway
Protein Synthesis: Lysine
Protein synthesis is an essential life process that builds the important large amino acid macromolecules that function as enzymes, antibodies, and cellular structural components. Although synthesis begins with the transcription of DNA into RNA, this pathway depicts the reactions that occur during translation. Transcribed messenger RNA (mRNA), which contains the genetic code to direct protein synthesis, is transported out of the nucleus and becomes bound to ribosomes in the cytoplasm or endoplasmic reticulum. The amino acids required to assemble polypeptide chains are delivered to the ribosomes using transfer RNA (tRNA). Each tRNA molecule has both a binding site for a specific amino acid and a three-nucleotide sequence called the anticodon that forms three complementary base pairs with an mRNA codon. Charging or loading the appropriate amino acid onto its tRNA is carried out by an aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase. This enzyme catalyzes the esterification of an amino acid to one of all its compatible tRNAs to form an aminoacyl-tRNA. Each of the twenty amino acids has a corresponding aa-tRNA made by a specific aminoacyl-tRNA synthetase. Ribosomes match the anticodons of the charged tRNA molecules with successive codons of the mRNA. After a match is found, the ribosome transfers the amino acid from the matching tRNA onto the growing peptide chain via a reaction termed peptide condensation, and the tRNAs, no longer carrying amino acids, are released.
Protein
PW120627
Center
PathwayVisualizationContext120903
1080
1600
#000099
PathwayVisualization112797
112934
Protein Synthesis: Lysine
Protein synthesis is an essential life process that builds the important large amino acid macromolecules that function as enzymes, antibodies, and cellular structural components. Although synthesis begins with the transcription of DNA into RNA, this pathway depicts the reactions that occur during translation. Transcribed messenger RNA (mRNA), which contains the genetic code to direct protein synthesis, is transported out of the nucleus and becomes bound to ribosomes in the cytoplasm or endoplasmic reticulum. The amino acids required to assemble polypeptide chains are delivered to the ribosomes using transfer RNA (tRNA). Each tRNA molecule has both a binding site for a specific amino acid and a three-nucleotide sequence called the anticodon that forms three complementary base pairs with an mRNA codon. Charging or loading the appropriate amino acid onto its tRNA is carried out by an aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase. This enzyme catalyzes the esterification of an amino acid to one of all its compatible tRNAs to form an aminoacyl-tRNA. Each of the twenty amino acids has a corresponding aa-tRNA made by a specific aminoacyl-tRNA synthetase. Ribosomes match the anticodons of the charged tRNA molecules with successive codons of the mRNA. After a match is found, the ribosome transfers the amino acid from the matching tRNA onto the growing peptide chain via a reaction termed peptide condensation, and the tRNAs, no longer carrying amino acids, are released.
Protein
5
109443
Lysine Biosynthesis
SubPathway
108922
118
Compound
122
1
Cell
CL:0000000
2
Platelet
CL:0000233
5
Hepatocyte
CL:0000182
3
Neuron
CL:0000540
4
Cardiomyocyte
CL:0000746
8
Beta cell
CL:0000639
7
Epithelial Cell
CL:0000066
6
Myocyte
CL:0000187
1
Homo sapiens
9606
Eukaryote
Human
2
Bacteria
2
Prokaryote
Bacteria
3
Escherichia coli
562
Prokaryote
12
Mus musculus
10090
Eukaryote
Mouse
17
Rattus norvegicus
10116
Eukaryote
Rat
19
Schizosaccharomyces pombe
4896
Eukaryote
24
Solanum lycopersicum
4081
Eukaryote
Tomato
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
21
Xenopus laevis
8355
Eukaryote
African clawed frog
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
25
Escherichia coli (strain K12)
83333
Prokaryote
49
Bathymodiolus platifrons
220390
Eukaryote
Deep sea mussel
23
Pseudomonas aeruginosa
287
Prokaryote
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
5
Bos taurus
9913
Eukaryote
Cattle
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
51
Picea sitchensis
3332
Eukaryote
Sitka spruce
1
Cytosol
GO:0005829
3
Mitochondrial Matrix
GO:0005759
5
Cytoplasm
GO:0005737
14
Mitochondrial Outer Membrane
GO:0005741
2
Mitochondrion
GO:0005739
15
Nucleus
GO:0005634
4
Peroxisome
GO:0005777
13
Endoplasmic Reticulum
GO:0005783
7
Endoplasmic Reticulum Membrane
GO:0005789
10
Cell Membrane
GO:0005886
27
Peroxisome Membrane
GO:0005778
31
Periplasmic Space
GO:0005620
11
Extracellular Space
GO:0005615
35
Chloroplast
GO:0009507
12
Mitochondrial Inner Membrane
GO:0005743
32
Inner Membrane
GO:0070258
17
Nucleoplasm
GO:0005654
6
Lysosome
GO:0005764
37
Basolateral cell membrane
GO:0016323
36
Membrane
GO:0016020
2
Endothelium
BTO:0000393
1
Liver
BTO:0000759
72
9
7
Nervous System
BTO:0001484
18
Pancreas
BTO:0000988
25
Intestine
BTO:0000648
8
Blood Vessel
BTO:0001102
74
11
11
Heart
BTO:0000562
73
10
9
Muscle
BTO:0000887
141
18
2
1
1
1
PW_BS000002
4
3
1
1
PW_BS000004
8
5
1
1
PW_BS000008
16
2
1
2
PW_BS000016
22
14
1
1
PW_BS000022
13
1
2
1
PW_BS000013
32
1
15
1
5
PW_BS000032
5
4
1
1
PW_BS000005
39
7
1
1
3
PW_BS000039
3
2
1
1
PW_BS000003
18
13
1
1
PW_BS000018
10
1
7
1
1
PW_BS000010
49
7
1
1
PW_BS000049
14
10
1
PW_BS000014
58
1
14
1
1
PW_BS000058
59
27
1
1
PW_BS000059
27
15
1
PW_BS000027
46
1
1
4
PW_BS000046
29
1
1
1
PW_BS000029
66
18
5
1
8
PW_BS000066
72
5
1
3
PW_BS000072
61
25
1
7
PW_BS000061
51
8
1
PW_BS000051
23
15
1
1
PW_BS000023
31
1
5
1
1
PW_BS000031
91
8
5
1
1
PW_BS000091
54
1
3
1
5
PW_BS000054
89
2
PW_BS000089
26
1
1
1
5
PW_BS000026
7
1
1
PW_BS000007
97
1
5
2
1
PW_BS000097
100
5
2
1
PW_BS000100
104
14
3
1
PW_BS000104
101
5
3
1
PW_BS000101
111
5
12
1
PW_BS000111
112
2
12
1
PW_BS000112
103
3
3
1
PW_BS000103
117
1
3
1
PW_BS000117
118
1
17
1
PW_BS000118
120
3
17
1
PW_BS000120
129
1
5
12
1
PW_BS000129
132
1
12
1
PW_BS000132
133
3
12
1
PW_BS000133
135
5
17
1
PW_BS000135
108
1
3
PW_BS000108
143
1
5
19
1
PW_BS000143
146
5
19
1
PW_BS000146
107
31
3
PW_BS000107
147
1
24
1
PW_BS000147
151
1
4
1
PW_BS000151
155
3
24
1
PW_BS000155
161
3
18
1
PW_BS000161
166
1
1
PW_BS000166
178
3
21
1
PW_BS000178
188
1
18
PW_BS000024
160
1
18
1
PW_BS000160
199
14
18
1
PW_BS000024
205
5
6
1
PW_BS000024
206
2
6
1
PW_BS000024
210
13
18
1
PW_BS000024
213
7
18
1
PW_BS000024
211
10
18
PW_BS000024
198
5
18
1
PW_BS000024
216
4
18
1
PW_BS000024
217
15
18
PW_BS000024
218
15
18
1
PW_BS000024
163
2
18
1
PW_BS000163
222
3
4
1
PW_BS000024
190
11
18
PW_BS000024
225
35
4
1
PW_BS000024
277
1
2
18
PW_BS000024
170
18
PW_BS000170
281
1
25
1
PW_BS000024
164
4
PW_BS000164
285
10
4
1
PW_BS000024
226
4
4
1
PW_BS000024
290
5
49
1
PW_BS000024
223
12
4
1
PW_BS000024
308
10
1
1
PW_BS000024
315
1
23
PW_BS000024
322
1
23
1
PW_BS000024
318
31
23
PW_BS000024
253
5
4
1
PW_BS000024
134
12
12
1
PW_BS000134
329
14
12
1
PW_BS000028
333
1
2
12
PW_BS000028
336
1
12
1
PW_BS000028
332
1
7
12
1
PW_BS000028
350
1
14
12
1
PW_BS000028
128
15
12
1
PW_BS000128
351
15
12
PW_BS000028
353
25
12
7
PW_BS000028
335
27
12
1
PW_BS000028
115
10
12
PW_BS000115
130
13
12
1
PW_BS000130
331
7
12
1
PW_BS000028
334
4
12
1
PW_BS000028
368
3
60
1
PW_BS000028
184
1
2
1
PW_BS000024
119
2
17
1
PW_BS000119
1
1
PW_BS000001
124
1
5
1
PW_BS000124
94
3
PW_BS000094
388
1
6
1
PW_BS000112
109
32
3
PW_BS000109
122
5
5
1
PW_BS000122
406
3
5
1
PW_BS000115
407
2
5
1
PW_BS000115
382
14
5
1
PW_BS000100
412
1
2
5
PW_BS000115
429
1
5
1
PW_BS000115
123
1
7
5
1
PW_BS000123
433
1
14
5
1
PW_BS000115
408
4
5
1
PW_BS000115
410
15
5
1
PW_BS000115
125
13
5
1
PW_BS000125
383
7
5
1
PW_BS000100
405
10
5
PW_BS000115
422
27
5
1
PW_BS000115
435
15
5
PW_BS000115
399
14
17
1
PW_BS000113
446
1
2
17
PW_BS000115
464
1
17
1
PW_BS000115
447
1
7
17
1
PW_BS000115
468
1
14
17
1
PW_BS000115
374
4
17
1
PW_BS000053
444
15
17
1
PW_BS000115
136
13
17
1
PW_BS000136
398
7
17
1
PW_BS000113
376
10
17
PW_BS000053
472
25
17
7
PW_BS000115
375
27
17
1
PW_BS000053
470
15
17
PW_BS000115
297
5
10
1
PW_BS000024
479
3
10
1
PW_BS000115
299
1
10
1
PW_BS000024
481
2
10
1
PW_BS000115
484
14
10
1
PW_BS000115
485
15
10
1
PW_BS000115
300
13
10
1
PW_BS000024
495
7
10
1
PW_BS000115
478
10
10
PW_BS000115
491
27
10
1
PW_BS000115
499
15
10
PW_BS000115
501
3
6
1
PW_BS000115
389
14
6
1
PW_BS000112
516
15
6
1
PW_BS000115
395
13
6
1
PW_BS000113
390
7
6
1
PW_BS000112
209
10
6
PW_BS000024
508
27
6
1
PW_BS000115
517
15
6
PW_BS000115
15
11
1
PW_BS000015
30
17
1
1
PW_BS000030
105
11
3
PW_BS000105
114
11
12
PW_BS000114
338
17
12
1
PW_BS000028
409
11
5
PW_BS000115
413
17
5
1
PW_BS000115
137
11
17
PW_BS000137
449
17
17
1
PW_BS000115
483
11
10
PW_BS000115
502
4
6
1
PW_BS000115
249
13
4
1
PW_BS000024
288
14
4
1
PW_BS000024
306
35
51
1
PW_BS000024
17
12
1
1
PW_BS000017
372
10
2
PW_BS000028
384
12
5
1
PW_BS000100
391
12
6
1
PW_BS000112
121
12
17
1
PW_BS000121
126
6
5
1
PW_BS000126
526
37
5
PW_BS000172
421
36
5
PW_BS000115
182
5
PW_BS000024
416
8
5
PW_BS000115
542
2
5
2
PW_BS000174
545
11
5
PW_BS000174
427
9
10
5
6
PW_BS000115
546
10
5
4
PW_BS000174
548
10
5
3
PW_BS000174
385
10
5
1
PW_BS000100
438
25
10
5
7
PW_BS000115
430
11
5
1
PW_BS000115
267
PW_B000267
751
11514
ProteinComplex
1
752
11515
ProteinComplex
1
753
490
ElementCollection
1
279
PW_B000279
798
45
NucleicAcid
1
799
11514
ProteinComplex
1
800
11515
ProteinComplex
1
801
490
ElementCollection
1
414
Adenosine triphosphate
HMDB0000538
Adenosine triphosphate (ATP) is a nucleotide consisting of a purine base (adenine) attached to the first carbon atom of ribose (a pentose sugar). Three phosphate groups are esterified at the fifth carbon atom of the ribose. ATP is incorporated into nucleic acids by polymerases in the processes of DNA replication and transcription. ATP contributes to cellular energy charge and participates in overall energy balance, maintaining cellular homeostasis. ATP can act as an extracellular signaling molecule via interactions with specific purinergic receptors to mediate a wide variety of processes as diverse as neurotransmission, inflammation, apoptosis, and bone remodelling. Extracellular ATP and its metabolite adenosine have also been shown to exert a variety of effects on nearly every cell type in human skin, and ATP seems to play a direct role in triggering skin inflammatory, regenerative, and fibrotic responses to mechanical injury, an indirect role in melanocyte proliferation and apoptosis, and a complex role in Langerhans cell-directed adaptive immunity. During exercise, intracellular homeostasis depends on the matching of adenosine triphosphate (ATP) supply and ATP demand. Metabolites play a useful role in communicating the extent of ATP demand to the metabolic supply pathways. Effects as different as proliferation or differentiation, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular ATP. The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. (PMID: 15490415, 15129319, 14707763, 14696970, 11157473).
56-65-5
C00002
5957
15422
ATP
5742
DB00171
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
C10H16N5O13P3
InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
ZKHQWZAMYRWXGA-KQYNXXCUSA-N
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
507.181
506.995745159
-2.05
7
adenosine triphosphate
0
-3
FDB021813
5'-(tetrahydrogen triphosphate) adenosine;5'-atp;Atp;Adenosine 5'-triphosphate;Adenosine 5'-triphosphorate;Adenosine 5'-triphosphoric acid;Adenosine triphosphate;Adenylpyrophosphorate;Adenylpyrophosphoric acid;Adephos;Adetol;Adynol;Atipi;Atriphos;Cardenosine;Fosfobion;Glucobasin;Myotriphos;Phosphobion;Striadyne;Triadenyl;Triphosphaden;Triphosphoric acid adenosine ester;Adenosine-5'-triphosphate;H4atp;Adenosine triphosphoric acid;Adenosine-5'-triphosphoric acid
PW_C000414
ATP
9
2
21
4
60
8
266
16
414
22
478
13
733
32
799
5
934
39
976
3
2105
18
2112
10
2146
49
2156
14
2160
58
2405
59
2434
27
2726
46
2812
29
3029
66
3163
72
3616
61
3617
51
4399
23
4474
31
4768
91
4864
54
5032
89
5035
26
5155
7
5205
97
5215
100
5250
104
5291
101
5313
111
5346
112
5390
103
5406
117
5430
118
5443
120
5542
129
5556
132
5569
133
5603
135
5621
108
5846
143
5854
146
5876
107
5897
147
5924
151
6048
155
6109
161
6230
166
6493
178
6839
188
6870
160
6976
199
7157
205
7184
206
7209
210
7225
213
7229
211
7298
198
7302
216
7390
217
7408
218
7432
163
7481
222
7499
190
8186
225
11847
277
11903
170
12010
281
12039
164
12178
285
12578
226
12691
290
13264
223
15327
308
42326
315
42621
322
42694
318
77028
253
77218
134
77233
329
77468
333
77632
336
78037
332
78041
350
78168
128
78214
351
78240
353
78411
335
78494
115
78850
130
78865
331
78919
334
80028
368
80046
184
80674
119
85629
1
94826
124
113234
94
113282
388
116280
109
119914
122
119992
406
120154
407
120245
382
120362
412
121246
429
121392
123
121397
433
121471
408
121974
410
122065
125
122079
383
122083
405
122402
422
122444
435
122919
399
123009
446
123816
464
123951
447
123956
468
124029
374
124527
444
124616
136
124630
398
124634
376
124943
472
124972
375
125011
470
125304
297
125371
479
125392
299
125515
481
125595
484
126123
485
126220
300
126234
495
126240
478
126547
491
126596
499
126913
501
127123
389
127731
516
127781
395
127796
390
127801
209
128119
508
128167
517
118
L-Lysine
HMDB0000182
L-lysine is an essential amino acid. Normal requirements for lysine have been found to be about 8 g per day or 12 mg/kg in adults. Children and infants need more- 44 mg/kg per day for an eleven to-twelve-year old, and 97 mg/kg per day for three-to six-month old. Lysine is highly concentrated in muscle compared to most other amino acids. Lysine is high in foods such as wheat germ, cottage cheese and chicken. Of meat products, wild game and pork have the highest concentration of lysine. Fruits and vegetables contain little lysine, except avocados. Normal lysine metabolism is dependent upon many nutrients including niacin, vitamin B6, riboflavin, vitamin C, glutamic acid and iron. Excess arginine antagonizes lysine. Several inborn errors of lysine metabolism are known. Most are marked by mental retardation with occasional diverse symptoms such as absence of secondary sex characteristics, undescended testes, abnormal facial structure, anemia, obesity, enlarged liver and spleen, and eye muscle imbalance. Lysine also may be a useful adjunct in the treatment of osteoporosis. Although high protein diets result in loss of large amounts of calcium in urine, so does lysine deficiency. Lysine may be an adjunct therapy because it reduces calcium losses in urine. Lysine deficiency also may result in immunodeficiency. Requirements for this amino acid are probably increased by stress. Lysine toxicity has not occurred with oral doses in humans. Lysine dosages are presently too small and may fail to reach the concentrations necessary to prove potential therapeutic applications. Lysine metabolites, amino caproic acid and carnitine have already shown their therapeutic potential. Thirty grams daily of amino caproic acid has been used as an initial daily dose in treating blood clotting disorders, indicating that the proper doses of lysine, its precursor, have yet to be used in medicine. Low lysine levels have been found in patients with Parkinson's, hypothyroidism, kidney disease, asthma and depression. The exact significance of these levels is unclear, yet lysine therapy can normalize the level and has been associated with improvement of some patients with these conditions. Abnormally elevated hydroxylysines have been found in virtually all chronic degenerative diseases and coumadin therapy. The levels of this stress marker may be improved by high doses of vitamin C. Lysine is particularly useful in therapy for marasmus (wasting) and herpes simplex. It stops the growth of herpes simplex in culture, and has helped to reduce the number and occurrence of cold sores in clinical studies. Dosing has not been adequately studied, but beneficial clinical effects occur in doses ranging from 100 mg to 4 g a day. Higher doses may also be useful, and toxicity has not been reported in doses as high as 8 g per day. Diets high in lysine and low in arginine can be useful in the prevention and treatment of herpes. Some researchers think herpes simplex virus is involved in many other diseases related to cranial nerves such as migraines, Bell's palsy and Meniere's disease. Herpes blister fluid will produce fatal encephalitis in the rabbit. (http://www.dcnutrition.com).
56-87-1
C00047
5962
18019
LYS
5747
DB00123
NCCCC[C@H](N)C(O)=O
C6H14N2O2
InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1
KDXKERNSBIXSRK-YFKPBYRVSA-N
(2S)-2,6-diaminohexanoic acid
146.1876
146.105527702
-0.14
3
L-lysine
0
1
FDB000474
(+)-s-lysine;(s)-2,6-diaminohexanoate;(s)-2,6-diaminohexanoic acid;(s)-2,6-diamino-hexanoate;(s)-2,6-diamino-hexanoic acid;(s)-lysine;(s)-a,e-diaminocaproate;(s)-a,e-diaminocaproic acid;2,6-diaminohexanoate;2,6-diaminohexanoic acid;6-amino-aminutrin;6-amino-l-norleucine;Aminutrin;L-(+)-lysine;L-2,6-diainohexanoate;L-2,6-diainohexanoic acid;L-2,6-diaminocaproate;L-2,6-diaminocaproic acid;L-lys;Lys;Lysine;Lysine acid;A-lysine;Alpha-lysine;H-lys-oh;(s)-alpha,epsilon-diaminocaproic acid;6-ammonio-l-norleucine;K;L-lysin;(s)-a,epsilon-diaminocaproate;(s)-a,epsilon-diaminocaproic acid;(s)-alpha,epsilon-diaminocaproate;(s)-α,epsilon-diaminocaproate;(s)-α,epsilon-diaminocaproic acid
PW_C000118
Lys
581
15
632
30
1065
3
1091
8
5299
105
5303
107
5304
108
5552
114
8214
225
42370
318
42371
315
77730
338
78275
112
78287
111
120504
409
120536
413
120780
407
120807
122
123110
137
123170
449
123372
119
123392
135
125719
483
32
Adenosine monophosphate
HMDB0000045
Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP can be produced during ATP synthesis by the enzyme adenylate kinase. AMP has recently been approved as a 'Bitter Blocker' additive to foodstuffs. When AMP is added to bitter foods or foods with a bitter aftertaste it makes them seem 'sweeter'. This potentially makes lower calorie food products more palatable.
61-19-8
C00020
6083
16027
AMP
5858
DB00131
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
C10H14N5O7P
InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
UDMBCSSLTHHNCD-KQYNXXCUSA-N
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
347.2212
347.063084339
-2.02
5
adenylate
0
-2
DBMET00485
FDB021806
5'-amp;5'-adenosine monophosphate;5'-adenylate;5'-adenylic acid;Amp;Adenosine 5'-monophosphate;Adenosine 5'-phosphate;Adenosine 5'-phosphorate;Adenosine 5'-phosphoric acid;Adenosine phosphate;Adenosine-5'-monophosphorate;Adenosine-5'-monophosphoric acid;Adenosine-5-monophosphorate;Adenosine-5-monophosphoric acid;Adenosine-monophosphate;Adenosine-phosphate;Adenovite;Adenylate;Adenylic acid;Cardiomone;Lycedan;Muscle adenylate;Muscle adenylic acid;My-b-den;My-beta-den;Phosaden;Phosphaden;Phosphentaside;5'-o-phosphonoadenosine;Adenosine 5'-(dihydrogen phosphate);Adenosine monophosphate;Adenosine-5'p;Adenosini phosphas;Ado5'p;Fosfato de adenosina;Pa;Pado;Phosphate d'adenosine;5'-adenosine monophosphoric acid;Adenosine phosphoric acid;Adenosine 5'-(dihydrogen phosphoric acid);Adenosine 5'-monophosphoric acid;Adenosine monophosphoric acid;Adenosine-5'-monophosphate;Phosphoric acid d'adenosine
PW_C000032
AMP
11
2
34
4
62
8
270
16
734
32
881
22
1189
14
4572
5
4867
54
5033
89
5251
104
5408
117
5423
103
5432
118
5457
120
5558
132
5583
133
5779
101
5795
108
6977
199
7072
188
11789
198
11868
161
11988
151
12003
222
12580
226
12636
31
12694
290
13331
225
42266
3
42646
315
77234
329
77325
111
78392
334
78809
115
79320
112
80399
1
80684
135
80900
7
119916
122
120016
124
120031
406
120246
382
120888
405
121954
408
122920
399
123464
376
124507
374
125306
297
125394
299
125409
479
125596
484
126853
205
126934
388
126949
501
127124
389
127311
209
127711
502
170
Pyrophosphate
HMDB0000250
The anion, the salts, and the esters of pyrophosphoric acid are called pyrophosphates. The pyrophosphate anion is abbreviated PPi and is formed by the hydrolysis of ATP into AMP in cells. This hydrolysis is called pyrophosphorolysis. The pyrophosphate anion has the structure P2O74-, and is an acid anhydride of phosphate. It is unstable in aqueous solution and rapidly hydrolyzes into inorganic phosphate. Pyrophosphate is an osteotoxin (arrests bone development) and an arthritogen (promotes arthritis). It is also a metabotoxin (an endogenously produced metabolite that causes adverse health affects at chronically high levels). Chronically high levels of pyrophosphate are associated with hypophosphatasia. Hypophosphatasia (also called deficiency of alkaline phosphatase or phosphoethanolaminuria) is a rare, and sometimes fatal, metabolic bone disease. Hypophosphatasia is associated with a molecular defect in the gene encoding tissue non-specific alkaline phosphatase (TNSALP). TNSALP is an enzyme that is tethered to the outer surface of osteoblasts and chondrocytes. TNSALP hydrolyzes several substances, including inorganic pyrophosphate (PPi) and pyridoxal 5'-phosphate (PLP), a major form of vitamin B6. When TSNALP is low, inorganic pyrophosphate (PPi) accumulates outside of cells and inhibits the formation of hydroxyapatite, one of the main components of bone, causing rickets in infants and children and osteomalacia (soft bones) in adults. Vitamin B6 must be dephosphorylated by TNSALP before it can cross the cell membrane. Vitamin B6 deficiency in the brain impairs synthesis of neurotransmitters which can cause seizures. In some cases, a build-up of calcium pyrophosphate dihydrate crystals in the joints can cause pseudogout.
14000-31-8
C00013
644102
18361
PPI
559142
DB04160
[O-]P([O-])(=O)OP([O-])([O-])=O
O7P2
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-4
XPPKVPWEQAFLFU-UHFFFAOYSA-J
(phosphonooxy)phosphonic acid
173.9433
173.911925378
4
pyrophosphoric acid
0
-3
FDB021918
(4-)diphosphoric acid ion;(p2o74-)diphosphate;Diphosphate;Diphosphoric acid;Ppi;Pyrometaphosphate;Pyrophosphate;Pyrophosphate tetraanion;Pyrophosphate(4-) ion;[o3popo3](4-);Diphosphat;P2o7(4-);Pyrophosphat;Pyrophosphate ion;Phosphonato phosphoric acid;Pyrophosphoric acid;Pyrophosphoric acid ion
PW_C000170
Ppi
12
2
35
4
63
8
429
23
735
32
882
22
1217
3
1620
49
2410
59
2815
29
4175
14
4868
54
5034
89
5252
104
5294
101
5409
117
5424
103
5433
118
5458
120
5548
111
5559
132
5584
133
5606
135
5655
108
5879
107
6239
166
6978
199
7073
188
7134
163
7272
160
7312
198
7318
213
8275
151
8283
210
11869
161
12002
222
12041
164
12315
225
12323
249
12512
288
12579
226
12695
290
15219
306
15375
18
34760
17
42561
315
42697
318
77235
329
77317
128
77635
336
78416
335
78928
331
79153
112
79950
134
79958
130
80047
372
80417
170
85630
1
94786
384
94814
125
94819
382
98678
223
110634
391
113270
395
113275
389
115527
136
115532
399
119934
122
120017
124
120032
406
120330
410
120936
407
121261
429
121341
121
121486
383
122407
422
122985
444
123502
119
123831
464
124044
398
124977
375
125324
297
125395
299
125410
479
125597
484
125656
485
125876
481
126552
491
126869
205
126935
388
126950
501
127337
206
128124
508
490
mRNA
NucleicAcid
NucleicAcid
PW_EC000490
mRNA
45
L-Lysyl-tRNA(Lys)
RNA
PW_NA000045
16047
LLTL
133681
8
133802
111
133843
122
133886
135
3662
45
12
122
true
1249
0
14
150
regular
150
70
44
tRNA(Lys)
RNA
945336
PW_NA000044
TRNALYS
133680
8
133803
111
133844
122
133887
135
20545
60S ribosomal protein L3
P39872
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
RPL3
5
133955
122
20548
60S ribosomal protein L4
Q58DW0
RPL4
5
133956
122
20551
60S ribosomal protein L5
Q58DW5
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B.
RPL5
5
133957
122
20553
60S ribosomal protein L6
Q58DQ3
Component of the large ribosomal subunit.
RPL6
5
133958
122
20555
60S ribosomal protein L7a
Q2TBQ5
RPL7A
5
133959
122
20558
60S ribosomal protein L7
Q58DT1
Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).
RPL7
5
133960
122
20561
60S ribosomal protein L8
Q3T0S6
Component of the large ribosomal subunit.
RPL8
5
133961
122
20565
60S ribosomal protein L9
Q3SYR7
RPL9
5
133962
122
20567
60S ribosomal protein L10a
Q5E9E6
Component of the large ribosomal subunit.
RPL10A
5
133963
122
20571
60S ribosomal protein L10
Q9XSI3
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
RPL10
5
133964
122
20574
60S ribosomal protein L11
Q3T087
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML.
RPL11
5
133965
122
20577
60S ribosomal protein L12
P61284
Binds directly to 26S ribosomal RNA.
RPL12
5
133966
122
20579
60S ribosomal protein L13a
Q3SZ90
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).
RPL13A
5
133967
122
20582
60S ribosomal protein L13
Q56JZ1
RPL13
5
133968
122
20585
60S ribosomal protein L14
Q3T0U2
Component of the large ribosomal subunit.
RPL14
5
133969
122
20587
60S ribosomal protein L15
Q5EAD6
RPL15
5
133970
122
20590
60S ribosomal protein L17
Q3T025
Component of the large ribosomal subunit.
RPL17
5
133971
122
20592
60S ribosomal protein L18a
Q3T003
RPL18A
5
133972
122
20594
60S ribosomal protein L18
Q5E973
Component of the large ribosomal subunit.
RPL18
5
133973
122
20596
60S ribosomal protein L19
Q3T0W9
RPL19
5
133974
122
20598
Similar to ribosomal protein L21
Q861S4
RPL21
5
133975
122
20602
Ribosomal protein L22
F1N301
RPL22
5
133976
122
20605
60S ribosomal protein L23a
Q24JY1
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity).
RPL23A
5
133977
122
20607
60S ribosomal protein L23
Q3T057
RPL23
5
133978
122
20609
60S ribosomal protein L24
Q862I1
RPL24
5
133979
122
20611
60S ribosomal protein L26
P61257
RPL26
5
133980
122
20614
60S ribosomal protein L27a
Q56K03
RPL27A
5
133981
122
20618
60S ribosomal protein L27
P61356
Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).
RPL27
5
133982
122
20620
60S ribosomal protein L28
Q3T0L7
Component of the large ribosomal subunit.
RPL28
5
133983
122
20623
60S ribosomal protein L29
Q58DW3
Component of the large ribosomal subunit.
RPL29
5
133984
122
20626
60S ribosomal protein L30
Q3T0D5
RPL30
5
133985
122
20629
60S ribosomal protein L31
Q56JX3
RPL31
5
133986
122
20631
60S ribosomal protein L32
Q3SZQ6
RPL32
5
133987
122
20634
Ribosomal protein L34
F1ML72
RPL34
5
133988
122
20636
60S ribosomal protein L35a
Q56JY1
Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity).
RPL35A
5
133989
122
20638
60S ribosomal protein L35
Q3MHM7
Component of the large ribosomal subunit.
RPL35
5
133990
122
20641
60S ribosomal protein L36a
Q3SZ59
RPL36A
5
133991
122
20644
60S ribosomal protein L36
Q3T171
Component of the large ribosomal subunit.
RPL36
5
133993
122
20647
60S ribosomal protein L37a
Q3MIC0
RPL37A
5
133995
122
20649
60S ribosomal protein L37
P79244
Binds to the 23S rRNA.
RPL37
5
133997
122
20651
60S ribosomal protein L38
Q32PB9
RPL38
5
133999
122
20654
60S ribosomal protein L39
Q3T051
RPL39
5
134000
122
20658
Ubiquitin-60S ribosomal protein L40
P63048
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
UBA52
5
134001
122
7764
Unknown
Unknown
5
3.1.1.1, 3.1.1.56
5473
123
5486
125
120135
122
120349
406
120525
124
121238
126
121241
429
122400
384
122507
405
131832
410
131877
435
132247
407
132250
526
132253
421
132587
409
132590
182
132592
416
132594
542
132599
545
132600
427
132601
546
132602
548
133000
385
133575
438
133591
383
135142
430
20660
60S acidic ribosomal protein P0
Q95140
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
RPLP0
5
134002
122
20663
60S acidic ribosomal protein P1
Q56K14
Plays an important role in the elongation step of protein synthesis.
RPLP1
5
134003
122
20665
60S acidic ribosomal protein P2
P42899
Plays an important role in the elongation step of protein synthesis.
RPLP2
5
134004
122
20686
40S ribosomal protein S2
O18789
RPS2
5
134005
122
20690
40S ribosomal protein S3
Q3T169
Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
RPS3
5
4.2.99.18
134006
122
20692
40S ribosomal protein S3a
Q56JV9
May play a role during erythropoiesis through regulation of transcription factor DDIT3.
RPS3A
5
134007
122
20695
40S ribosomal protein S4
P79103
RPS4
5
134008
122
20698
40S ribosomal protein S5
Q5E988
RPS5
5
134009
122
20702
40S ribosomal protein S6
Q5E995
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
RPS6
5
134010
122
20704
40S ribosomal protein S7
A6H769
Required for rRNA maturation.
RPS7
5
134011
122
20707
40S ribosomal protein S8
Q5E958
RPS8
5
134012
122
20709
40S ribosomal protein S9
A6QLG5
RPS9
5
134013
122
20712
40S ribosomal protein S10
Q3T0F4
Component of the 40S ribosomal subunit.
RPS10
5
134014
122
20714
40S ribosomal protein S11
Q3T0V4
RPS11
5
134015
122
20716
40S ribosomal protein S12
Q76I81
RPS12
5
134016
122
20719
40S ribosomal protein S13
Q56JX8
RPS13
5
134017
122
20722
Similar to ribosomal protein S14
Q862B7
5
134018
122
20724
40S ribosomal protein S15
Q56K10
RPS15
5
134019
122
20726
40S ribosomal protein S15a
Q76I82
RPS15A
5
134020
122
20729
40S ribosomal protein S16
Q3T0X6
RPS16
5
134021
122
20732
40S ribosomal protein S17
A5PK63
RPS17
5
134022
122
20734
40S ribosomal protein S18
Q3T0R1
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
RPS18
5
134023
122
20736
40S ribosomal protein S19
Q32PD5
Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
RPS19
5
134024
122
20739
40S ribosomal protein S20
Q3ZBH8
RPS20
5
134025
122
20742
40S ribosomal protein S21
Q32PB8
RPS21
5
134026
122
20744
40S ribosomal protein S23
Q3T199
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy.
RPS23
5
134027
122
20747
40S ribosomal protein S24
Q56JU9
Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.
RPS24
5
134028
122
20750
40S ribosomal protein S25
Q56JX5
RPS25
5
134029
122
20753
40S ribosomal protein S26
Q56JV1
RPS26
5
134030
122
20756
40S ribosomal protein S27
Q2KHT7
Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity).
RPS27
5
134031
122
20759
40S ribosomal protein S28
Q56JX6
RPS28
5
134032
122
20762
40S ribosomal protein S29
P62276
RPS29
5
134033
122
20764
40S ribosomal protein S30
P62866
FAU
5
134034
122
20767
40S ribosomal protein SA
P26452
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
RPSA
5
134035
122
20770
Receptor of activated protein C kinase 1
P63243
Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (By similarity). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity).
RACK1
5
134036
122
20225
Lysine--tRNA ligase
Q3T0N2
KARS
5
6.1.1.6
133845
122
11514
Large 60S Ribosomal Subunit
5
PW_P011514
20542
20545
20543
20548
20544
20551
20545
20553
20546
20555
20547
20558
20548
20561
20549
20565
20550
20567
20551
20571
20552
20574
20553
20577
20554
20579
20555
20582
20556
20585
20557
20587
20558
20590
20559
20592
20560
20594
20561
20596
20562
20598
20563
20602
20564
20605
20565
20607
20566
20609
20567
20611
20568
20614
20569
20618
20570
20620
20571
20623
20572
20626
20573
20629
20574
20631
20575
20634
20576
20636
20577
20638
20578
20641
20579
20644
20580
20647
20581
20649
20582
20651
20583
20654
20584
20658
20585
20660
20586
20663
20587
20665
11515
Small 40S Ribosomal Subunit
5
PW_P011515
20588
20686
20589
20690
20590
20692
20591
20695
20592
20698
20593
20702
20594
20704
20595
20707
20596
20709
20597
20712
20598
20714
20599
20716
20600
20719
20601
20722
20602
20724
20603
20726
20604
20729
20605
20732
20606
20734
20607
20736
20608
20739
20609
20742
20610
20744
20611
20747
20612
20750
20613
20753
20614
20756
20615
20759
20616
20762
20617
20764
20618
20767
20619
20770
11520
Lysine--tRNA ligase
5
PW_P011520
20515
20225
2
133846
122
178916
PW_R178916
Right
675150
45
1
NucleicAcid
false
675151
267
1
Bound
false
675152
279
1
Bound
false
178917
PW_R178917
Right
675153
414
1
Compound
false
675154
118
1
Compound
false
675155
44
1
NucleicAcid
false
675156
32
1
Compound
false
675157
170
1
Compound
false
675158
45
1
NucleicAcid
false
168986
11520
1515
267
122
112797
697
14453
3645605
2154
799468
3645606
2155
799469
3645607
1516
279
122
112797
698
14454
3645609
115
3662
3645610
2156
799470
3645611
2157
799471
3645612
2673237
414
122
42
false
335
702
10
regular
50
30
2673238
118
122
3
false
295
413
10
regular
100
100
2673239
32
122
44
false
645
700
10
regular
50
30
2673240
170
122
45
false
638
465
10
regular
63
43
14453
490
37
122
true
769
0
12
regular
100
90
14454
490
37
122
true
1159
0
12
regular
100
90
3661
45
96
122
false
689
580
14
120
nucleic_acid
regular
120
115
3662
45
12
122
true
1249
0
14
150
regular
150
70
3663
44
96
122
false
225
577
14
120
nucleic_acid
regular
120
115
938384
20545
122
2
true
629
0
8
subunit
regular
150
70
938385
20548
122
2
true
629
60
8
subunit
regular
150
70
938386
20551
122
2
true
629
120
8
subunit
regular
150
70
938387
20553
122
2
true
629
180
8
subunit
regular
150
70
938388
20555
122
2
true
629
240
8
subunit
regular
150
70
938389
20558
122
2
true
629
300
8
subunit
regular
150
70
938390
20561
122
2
true
629
360
8
subunit
regular
150
70
938391
20565
122
2
true
629
420
8
subunit
regular
150
70
938392
20567
122
2
true
629
480
8
subunit
regular
150
70
938393
20571
122
2
true
629
540
8
subunit
regular
150
70
938394
20574
122
2
true
629
600
8
subunit
regular
150
70
938395
20577
122
2
true
629
660
8
subunit
regular
150
70
938396
20579
122
2
true
629
720
8
subunit
regular
150
70
938397
20582
122
2
true
629
780
8
subunit
regular
150
70
938398
20585
122
2
true
629
840
8
subunit
regular
150
70
938399
20587
122
2
true
629
900
8
subunit
regular
150
70
938400
20590
122
2
true
629
960
8
subunit
regular
150
70
938401
20592
122
2
true
629
1020
8
subunit
regular
150
70
938402
20594
122
2
true
629
1080
8
subunit
regular
150
70
938403
20596
122
2
true
629
1140
8
subunit
regular
150
70
938404
20598
122
2
true
629
1200
8
subunit
regular
150
70
938405
20602
122
2
true
629
1260
8
subunit
regular
150
70
938406
20605
122
2
true
629
1320
8
subunit
regular
150
70
938407
20607
122
2
true
629
1380
8
subunit
regular
150
70
938408
20609
122
2
true
629
1440
8
subunit
regular
150
70
938409
20611
122
2
true
629
1500
8
subunit
regular
150
70
938410
20614
122
2
true
629
1560
8
subunit
regular
150
70
938411
20618
122
2
true
629
1620
8
subunit
regular
150
70
938412
20620
122
2
true
629
1680
8
subunit
regular
150
70
938413
20623
122
2
true
629
1740
8
subunit
regular
150
70
938414
20626
122
2
true
629
1800
8
subunit
regular
150
70
938415
20629
122
2
true
629
1860
8
subunit
regular
150
70
938416
20631
122
2
true
629
1920
8
subunit
regular
150
70
938417
20634
122
2
true
629
1980
8
subunit
regular
150
70
938418
20636
122
2
true
629
2040
8
subunit
regular
150
70
938419
20638
122
2
true
629
2100
8
subunit
regular
150
70
938420
20641
122
2
true
629
2160
8
subunit
regular
150
70
938421
20644
122
2
true
629
2220
8
subunit
regular
150
70
938422
20647
122
2
true
629
2280
8
subunit
regular
150
70
938423
20649
122
2
true
629
2340
8
subunit
regular
150
70
938424
20651
122
2
true
629
2400
8
subunit
regular
150
70
938425
20654
122
2
true
629
2460
8
subunit
regular
150
70
938426
20658
122
2
true
629
2520
8
subunit
regular
150
70
938427
7764
122
2
true
629
2580
8
subunit
regular
150
70
938428
20660
122
2
true
629
2640
8
subunit
regular
150
70
938429
20663
122
2
true
629
2700
8
subunit
regular
150
70
938430
20665
122
2
true
629
2760
8
subunit
regular
150
70
938431
20686
122
2
true
629
2820
8
subunit
regular
150
70
938432
20690
122
2
true
629
2880
8
subunit
regular
150
70
938433
20692
122
2
true
629
2940
8
subunit
regular
150
70
938434
20695
122
2
true
629
3000
8
subunit
regular
150
70
938435
20698
122
2
true
629
3060
8
subunit
regular
150
70
938436
20702
122
2
true
629
3120
8
subunit
regular
150
70
938437
20704
122
2
true
629
3180
8
subunit
regular
150
70
938438
20707
122
2
true
629
3240
8
subunit
regular
150
70
938439
20709
122
2
true
629
3300
8
subunit
regular
150
70
938440
20712
122
2
true
629
3360
8
subunit
regular
150
70
938441
20714
122
2
true
629
3420
8
subunit
regular
150
70
938442
20716
122
2
true
629
3480
8
subunit
regular
150
70
938443
20719
122
2
true
629
3540
8
subunit
regular
150
70
938444
20722
122
2
true
629
3600
8
subunit
regular
150
70
938445
20724
122
2
true
629
3660
8
subunit
regular
150
70
938446
20726
122
2
true
629
3720
8
subunit
regular
150
70
938447
20729
122
2
true
629
3780
8
subunit
regular
150
70
938448
20732
122
2
true
629
3840
8
subunit
regular
150
70
938449
20734
122
2
true
629
3900
8
subunit
regular
150
70
938450
20736
122
2
true
629
3960
8
subunit
regular
150
70
938451
20739
122
2
true
629
4020
8
subunit
regular
150
70
938452
20742
122
2
true
629
4080
8
subunit
regular
150
70
938453
20744
122
2
true
629
4140
8
subunit
regular
150
70
938454
20747
122
2
true
629
4200
8
subunit
regular
150
70
938455
20750
122
2
true
629
4260
8
subunit
regular
150
70
938456
20753
122
2
true
629
4320
8
subunit
regular
150
70
938457
20756
122
2
true
629
4380
8
subunit
regular
150
70
938458
20759
122
2
true
629
4440
8
subunit
regular
150
70
938459
20762
122
2
true
629
4500
8
subunit
regular
150
70
938460
20764
122
2
true
629
4560
8
subunit
regular
150
70
938461
20767
122
2
true
629
4620
8
subunit
regular
150
70
938462
20770
122
2
true
629
4680
8
subunit
regular
150
70
938463
20545
122
188
false
1030
596
2
none
regular
300
140
938464
20548
122
2
true
1019
60
8
subunit
regular
150
70
938465
20551
122
2
true
1019
120
8
subunit
regular
150
70
938466
20553
122
2
true
1019
180
8
subunit
regular
150
70
938467
20555
122
2
true
1019
240
8
subunit
regular
150
70
938468
20558
122
2
true
1019
300
8
subunit
regular
150
70
938469
20561
122
2
true
1019
360
8
subunit
regular
150
70
938470
20565
122
2
true
1019
420
8
subunit
regular
150
70
938471
20567
122
2
true
1019
480
8
subunit
regular
150
70
938472
20571
122
2
true
1019
540
8
subunit
regular
150
70
938473
20574
122
2
true
1019
600
8
subunit
regular
150
70
938474
20577
122
2
true
1019
660
8
subunit
regular
150
70
938475
20579
122
2
true
1019
720
8
subunit
regular
150
70
938476
20582
122
2
true
1019
780
8
subunit
regular
150
70
938477
20585
122
2
true
1019
840
8
subunit
regular
150
70
938478
20587
122
2
true
1019
900
8
subunit
regular
150
70
938479
20590
122
2
true
1019
960
8
subunit
regular
150
70
938480
20592
122
2
true
1019
1020
8
subunit
regular
150
70
938481
20594
122
2
true
1019
1080
8
subunit
regular
150
70
938482
20596
122
2
true
1019
1140
8
subunit
regular
150
70
938483
20598
122
2
true
1019
1200
8
subunit
regular
150
70
938484
20602
122
2
true
1019
1260
8
subunit
regular
150
70
938485
20605
122
2
true
1019
1320
8
subunit
regular
150
70
938486
20607
122
2
true
1019
1380
8
subunit
regular
150
70
938487
20609
122
2
true
1019
1440
8
subunit
regular
150
70
938488
20611
122
2
true
1019
1500
8
subunit
regular
150
70
938489
20614
122
2
true
1019
1560
8
subunit
regular
150
70
938490
20618
122
2
true
1019
1620
8
subunit
regular
150
70
938491
20620
122
2
true
1019
1680
8
subunit
regular
150
70
938492
20623
122
2
true
1019
1740
8
subunit
regular
150
70
938493
20626
122
2
true
1019
1800
8
subunit
regular
150
70
938494
20629
122
2
true
1019
1860
8
subunit
regular
150
70
938495
20631
122
2
true
1019
1920
8
subunit
regular
150
70
938496
20634
122
2
true
1019
1980
8
subunit
regular
150
70
938497
20636
122
2
true
1019
2040
8
subunit
regular
150
70
938498
20638
122
2
true
1019
2100
8
subunit
regular
150
70
938499
20641
122
2
true
1019
2160
8
subunit
regular
150
70
938500
20644
122
2
true
1019
2220
8
subunit
regular
150
70
938501
20647
122
2
true
1019
2280
8
subunit
regular
150
70
938502
20649
122
2
true
1019
2340
8
subunit
regular
150
70
938503
20651
122
2
true
1019
2400
8
subunit
regular
150
70
938504
20654
122
2
true
1019
2460
8
subunit
regular
150
70
938505
20658
122
2
true
1019
2520
8
subunit
regular
150
70
938506
7764
122
2
true
1019
2580
8
subunit
regular
150
70
938507
20660
122
2
true
1019
2640
8
subunit
regular
150
70
938508
20663
122
2
true
1019
2700
8
subunit
regular
150
70
938509
20665
122
2
true
1019
2760
8
subunit
regular
150
70
938510
20686
122
186
false
1050
766
2
none
regular
150
70
938511
20690
122
186
false
1175
766
2
none
regular
150
70
938512
20692
122
2
true
1019
2940
8
subunit
regular
150
70
938513
20695
122
2
true
1019
3000
8
subunit
regular
150
70
938514
20698
122
2
true
1019
3060
8
subunit
regular
150
70
938515
20702
122
2
true
1019
3120
8
subunit
regular
150
70
938516
20704
122
2
true
1019
3180
8
subunit
regular
150
70
938517
20707
122
2
true
1019
3240
8
subunit
regular
150
70
938518
20709
122
2
true
1019
3300
8
subunit
regular
150
70
938519
20712
122
2
true
1019
3360
8
subunit
regular
150
70
938520
20714
122
2
true
1019
3420
8
subunit
regular
150
70
938521
20716
122
2
true
1019
3480
8
subunit
regular
150
70
938522
20719
122
2
true
1019
3540
8
subunit
regular
150
70
938523
20722
122
2
true
1019
3600
8
subunit
regular
150
70
938524
20724
122
2
true
1019
3660
8
subunit
regular
150
70
938525
20726
122
2
true
1019
3720
8
subunit
regular
150
70
938526
20729
122
2
true
1019
3780
8
subunit
regular
150
70
938527
20732
122
2
true
1019
3840
8
subunit
regular
150
70
938528
20734
122
2
true
1019
3900
8
subunit
regular
150
70
938529
20736
122
2
true
1019
3960
8
subunit
regular
150
70
938530
20739
122
2
true
1019
4020
8
subunit
regular
150
70
938531
20742
122
2
true
1019
4080
8
subunit
regular
150
70
938532
20744
122
2
true
1019
4140
8
subunit
regular
150
70
938533
20747
122
2
true
1019
4200
8
subunit
regular
150
70
938534
20750
122
2
true
1019
4260
8
subunit
regular
150
70
938535
20753
122
2
true
1019
4320
8
subunit
regular
150
70
938536
20756
122
2
true
1019
4380
8
subunit
regular
150
70
938537
20759
122
2
true
1019
4440
8
subunit
regular
150
70
938538
20762
122
2
true
1019
4500
8
subunit
regular
150
70
938539
20764
122
2
true
1019
4560
8
subunit
regular
150
70
938540
20767
122
2
true
1019
4620
8
subunit
regular
150
70
938541
20770
122
2
true
1019
4680
8
subunit
regular
150
70
938542
20225
122
6
false
437
570
8
subunit
regular
160
80
799468
11514
112797
122
934547
938384
934548
938385
934549
938386
934550
938387
934551
938388
934552
938389
934553
938390
934554
938391
934555
938392
934556
938393
934557
938394
934558
938395
934559
938396
934560
938397
934561
938398
934562
938399
934563
938400
934564
938401
934565
938402
934566
938403
934567
938404
934568
938405
934569
938406
934570
938407
934571
938408
934572
938409
934573
938410
934574
938411
934575
938412
934576
938413
934577
938414
934578
938415
934579
938416
934580
938417
934581
938418
934582
938419
934583
938420
934584
938421
934585
938422
934586
938423
934587
938424
934588
938425
934589
938426
934590
938427
934591
938428
934592
938429
934593
938430
799469
11515
112797
122
934594
938431
934595
938432
934596
938433
934597
938434
934598
938435
934599
938436
934600
938437
934601
938438
934602
938439
934603
938440
934604
938441
934605
938442
934606
938443
934607
938444
934608
938445
934609
938446
934610
938447
934611
938448
934612
938449
934613
938450
934614
938451
934615
938452
934616
938453
934617
938454
934618
938455
934619
938456
934620
938457
934621
938458
934622
938459
934623
938460
934624
938461
934625
938462
799470
11514
112797
122
934626
938463
934627
938464
934628
938465
934629
938466
934630
938467
934631
938468
934632
938469
934633
938470
934634
938471
934635
938472
934636
938473
934637
938474
934638
938475
934639
938476
934640
938477
934641
938478
934642
938479
934643
938480
934644
938481
934645
938482
934646
938483
934647
938484
934648
938485
934649
938486
934650
938487
934651
938488
934652
938489
934653
938490
934654
938491
934655
938492
934656
938493
934657
938494
934658
938495
934659
938496
934660
938497
934661
938498
934662
938499
934663
938500
934664
938501
934665
938502
934666
938503
934667
938504
934668
938505
934669
938506
934670
938507
934671
938508
934672
938509
799471
11515
112797
122
934673
938510
934674
938511
934675
938512
934676
938513
934677
938514
934678
938515
934679
938516
934680
938517
934681
938518
934682
938519
934683
938520
934684
938521
934685
938522
934686
938523
934687
938524
934688
938525
934689
938526
934690
938527
934691
938528
934692
938529
934693
938530
934694
938531
934695
938532
934696
938533
934697
938534
934698
938535
934699
938536
934700
938537
934701
938538
934702
938539
934703
938540
934704
938541
799472
11520
112797
122
934705
938542
3645605
M764 -5 L764 45 L814 -5 z
10
true
18
3645606
M9 610 L9 660 L59 610 z
10
true
18
3645607
M9 3430 L9 3480 L59 3430 z
10
true
18
3645608
M869 50 C899 50 949 -588.75 979 -588.75
5
true
18
3645609
M1154 -5 L1154 45 L1204 -5 z
10
true
18
3645610
M1244 -5 L1244 45 L1294 -5 z
10
true
18
3645611
M9 1000 L9 1050 L59 1000 z
10
true
18
3645612
M9 3820 L9 3870 L59 3820 z
10
true
18
3645613
M1249 35 C1219 35 1009 -588.75 979 -588.75
5
true
18
true
M 39.946855044164835 242.26155629629605 L 25 241 L 31.380887721185843 254.57513432307834
false
3645614
M805 609 C918 649 969 670 1149 740
5
false
18
true
M 888.9749045598433 581.96644186147 L 901 573 L 887.2222858463324 567.0691827966269
false
3645615
M385 717 C390 655 407 610 437 610
5
false
18
3645616
M395 463 C393 528 413 611 437 610
5
false
18
3645617
M645 715 C644 641 627 610 597 610
5
false
18
true
M 25.946855044164835 174.26155629629605 L 11 173 L 17.380887721185843 186.57513432307834
false
3645618
M638 486.5 C639 549.5 627 610 597 610
5
false
18
true
M 25.946855044164835 174.26155629629605 L 11 173 L 17.380887721185843 186.57513432307834
false
3645619
M340 607 C370 607 407 610 437 610
5
false
18
3645620
M694 610 C664 610 627 610 597 610
5
false
18
true
M 25.946855044164835 174.26155629629605 L 11 173 L 17.380887721185843 186.57513432307834
false
3645621
M345 413 C345 383 345 344 345 314
5
false
18
true
M 197.5 395.0096189432334 L 205 408 L 212.5 395.0096189432334
false
795620
112797
178916
122
1043
1515
3645608
Left
1044
1516
3645613
Right
1641
3661
3645614
Left
795621
112797
178917
122
3217623
2673237
3645615
Left
3217624
2673238
3645616
Left
3217625
2673239
3645617
Right
3217626
2673240
3645618
Right
1642
3663
3645619
Left
1643
3661
3645620
Right
751830
168986
799472
109086
109443
112797
217
false
270
244
16
regular
105835
2673238
3645621
Right
185707
685
172
0.4
0.4
0
1
42
1785
1645
369156
M128 226.5 C128 176.5 178 126.5 228 126.5 C576 126.5 1028 126.5 1376 126.5 C1426 126.5 1476 176.5 1476 226.5 C1476 419.5 1476 669.5 1476 862.5 C1476 912.5 1426 962.5 1376 962.5 C1028 962.5 576 962.5 228 962.5 C178 962.5 128 912.5 128 862.5 C128 669.5 128 419.5 128 226.5
1
true
6
0.0
0.0
449231
15
mRNA
595
746
20
1.3
1.3
160
15
449232
15
Polypeptide Chain
885
442
20
1.3
1.3
160
15
449233
235
Translation
1021
799
20
1.6
1.6
200
15
449234
15
Ribosome
1242
580
20
1.3
1.3
160
15
449235
15
Cytoplasm
1207
173
20
1.3
1.3
160
15