Reference/KEGG Compound C00438
type: UnificationXref
id: C00438
db: KEGG Compound

3'-AMP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28931
xref: Reference/PubChem-compound 41211
xref: Reference/ChemSpider 37610
xref: Reference/CAS 84-21-9
xref: Reference/KEGG Compound C01367
xref: Reference/HMDB HMDB0003540
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C001918

Reference/KEGG Compound C00672
type: UnificationXref
id: C00672
db: KEGG Compound

Reference/CAS 964-26-1
type: UnificationXref
id: 964-26-1
db: CAS

Compound/PW C001189 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP
stoichiometric coefficient: 1.0

Reference/ChemSpider 58580
type: UnificationXref
id: 58580
db: ChemSpider

Reference/PathWhiz PW121724
type: UnificationXref
id: PW121724
db: PathWhiz

Compound/PW C000950 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Thymidylic acid
stoichiometric coefficient: 1.0

3.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001363 Cytosol/Stoichiometry/1.0
right: Ureidoisobutyric acid
right: Ammonia
right: Carbon dioxide
spontaneous: false
EC number: 3.5.1.6
left: Ureidoisobutyric acid
left: Water
name: Ureidoisobutyric acid + Water → Ammonia + Carbon dioxide + Ureidoisobutyric acid
conversion direction: LEFT_TO_RIGHT

3.6.1.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000927 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: dUMP
spontaneous: false
EC number: 3.6.1.23
left: Deoxyuridine triphosphate
left: Water
name: Deoxyuridine triphosphate + Water → Phosphate + dUMP
conversion direction: LEFT_TO_RIGHT

dUDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dUDP

1.17.4.1
type: BiochemicalReaction
participant stoichiometry: Protein/Generic27 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000792 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic28 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
right: dUDP
right: Thioredoxin
spontaneous: false
EC number: 1.17.4.1
left: Uridine 5'-diphosphate
left: Thioredoxin disulfide
left: Water
name: Thioredoxin disulfide + Uridine 5'-diphosphate + Water → Thioredoxin + dUDP
conversion direction: LEFT_TO_RIGHT

2.7.1.48
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000202 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Uridine 5'-monophosphate
spontaneous: false
EC number: 2.7.1.48
left: Adenosine triphosphate
left: Uridine
name: Adenosine triphosphate + Uridine → Adenosine diphosphate + Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000792 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000927 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: dUDP
spontaneous: false
EC number: 2.7.4.6
left: Adenosine diphosphate
left: Deoxyuridine triphosphate
name: Adenosine diphosphate + Deoxyuridine triphosphate → Adenosine triphosphate + dUDP
conversion direction: LEFT_TO_RIGHT

2.1.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000792 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dUDP
spontaneous: false
EC number: 2.1.1.45
left: Adenosine triphosphate
left: dUMP
name: Adenosine triphosphate + dUMP ↔ Adenosine diphosphate + dUDP
conversion direction: REVERSIBLE

3.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001993 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001363 Cytosol/Stoichiometry/1.0
right: Ammonia
right: 3-Aminoisobutanoic acid
right: Carbon dioxide
spontaneous: false
EC number: 3.5.1.6
left: Ureidoisobutyric acid
left: Water
name: Ureidoisobutyric acid + Water → 3-Aminoisobutanoic acid + Ammonia + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Reference/PubChem-compound 6132
type: UnificationXref
id: 6132
db: PubChem-compound

Dihydrofolic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00415
xref: Reference/BioCyc DIHYDROFOLATE
xref: Reference/ChEBI CHEBI 15633
xref: Reference/ChemSpider 89228
xref: Reference/PubChem-compound 98792
xref: Reference/HMDB HMDB0001056
xref: Reference/CAS 4033-27-6
chemical formula: C19H21N7O6
molecular weight: 443.15533
structure: ChemicalStructure/PW C000831

Reference/CAS 2905-86-4
type: UnificationXref
id: 2905-86-4
db: CAS

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/ChEBI CHEBI 27389
type: UnificationXref
id: CHEBI:27389
db: ChEBI

Reference/CAS 13184-27-5
type: UnificationXref
id: 13184-27-5
db: CAS

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

L-Dihydroorotic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dihydroorotic acid

Reference/CAS 63-38-7
type: UnificationXref
id: 63-38-7
db: CAS

Reference/ChEBI CHEBI 17568
type: UnificationXref
id: CHEBI:17568
db: ChEBI

Reference/KEGG Compound C00459
type: UnificationXref
id: C00459
db: KEGG Compound

Reference/KEGG Compound C00458
type: UnificationXref
id: C00458
db: KEGG Compound

3.5.4.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000937 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: dUMP
spontaneous: false
EC number: 3.5.4.12
left: dCMP
left: Water
name: Water + dCMP → Ammonia + dUMP
conversion direction: LEFT_TO_RIGHT

2.7.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dUMP
spontaneous: false
EC number: 2.7.1.21
left: Adenosine triphosphate
left: Deoxyuridine
name: Adenosine triphosphate + Deoxyuridine → Adenosine diphosphate + dUMP
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/CAS 365-08-2
type: UnificationXref
id: 365-08-2
db: CAS

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C000202 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00214
type: UnificationXref
id: C00214
db: KEGG Compound

Reference/PathWhiz PW000162
type: UnificationXref
id: PW000162
db: PathWhiz

Reference/ChEBI CHEBI 17562
type: UnificationXref
id: CHEBI:17562
db: ChEBI

Reference/ChemSpider 1141
type: UnificationXref
id: 1141
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

ChemicalStructure/PW C001087
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Reference/PubChem-compound 439175
type: UnificationXref
id: 439175
db: PubChem-compound

Thioredoxin
type: Protein
cellular location: Cytosol
entity reference: Thioredoxin

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000962 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000790 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: dCTP
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.6
left: Adenosine triphosphate
left: dCDP
name: Adenosine triphosphate + dCDP → Adenosine diphosphate + dCTP
conversion direction: LEFT_TO_RIGHT

Reaction110323
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000962 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000937 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dCDP
spontaneous: false
left: Adenosine triphosphate
left: dCMP
name: Adenosine triphosphate + dCMP → Adenosine diphosphate + dCDP
conversion direction: LEFT_TO_RIGHT

3.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000018 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: β-Alanine
right: Carbon dioxide
spontaneous: false
EC number: 3.5.1.6
left: Ureidopropionic acid
left: Water
name: Ureidopropionic acid + Water → Ammonia + Carbon dioxide + β-Alanine
conversion direction: LEFT_TO_RIGHT

1.17.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/Generic53 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000962 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic54 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: dCDP
right: thioredoxin
spontaneous: false
EC number: 1.17.4.1
left: thioredoxin disulfide
left: CDP
left: Water
name: CDP + Water + thioredoxin disulfide → dCDP + thioredoxin
conversion direction: LEFT_TO_RIGHT

3.5.4.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000008 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Deoxyuridine
spontaneous: false
EC number: 3.5.4.5
left: Deoxycytidine
left: Water
name: Deoxycytidine + Water → Ammonia + Deoxyuridine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 64968
type: UnificationXref
id: 64968
db: PubChem-compound

2.4.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000204 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001042 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Deoxyribose 1-phosphate
right: Uracil
spontaneous: false
EC number: 2.4.2.4
left: Phosphate
left: Deoxyuridine
name: Deoxyuridine + Phosphate → Deoxyribose 1-phosphate + Uracil
conversion direction: LEFT_TO_RIGHT

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000008 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000937 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Deoxycytidine
spontaneous: false
EC number: 3.1.3.5
left: dCMP
left: Water
name: Water + dCMP → Deoxycytidine + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.48
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000008 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000937 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dCMP
spontaneous: false
EC number: 2.7.1.48
left: Adenosine triphosphate
left: Deoxycytidine
name: Adenosine triphosphate + Deoxycytidine → Adenosine diphosphate + dCMP
conversion direction: LEFT_TO_RIGHT

Protein/7725 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

3.5.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000056 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001363 Cytosol/Stoichiometry/1.0
right: Ureidoisobutyric acid
spontaneous: false
EC number: 3.5.2.2
left: Dihydrothymine
left: Water
name: Dihydrothymine + Water → Ureidoisobutyric acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C02642
type: UnificationXref
id: C02642
db: KEGG Compound

Reference/KEGG Compound C00460
type: UnificationXref
id: C00460
db: KEGG Compound

Compound/Generic54 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: thioredoxin
stoichiometric coefficient: 1.0

Thymidine 5'-triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thymidine 5'-triphosphate
name: SubPathwayInput

2.1.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000831 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001178 Cytosol/Stoichiometry/1.0
right: 5-Thymidylic acid
right: Dihydrofolic acid
spontaneous: false
EC number: 2.1.1.45
left: 5,10-Methylene-THF
left: dUMP
name: 5,10-Methylene-THF + dUMP → 5-Thymidylic acid + Dihydrofolic acid
conversion direction: LEFT_TO_RIGHT

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Thymidine 5'-triphosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.6
left: Adenosine triphosphate
left: dTDP
name: Adenosine triphosphate + dTDP ↔ Adenosine diphosphate + Thymidine 5'-triphosphate
conversion direction: REVERSIBLE

3.6.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: dTDP
spontaneous: false
EC number: 3.6.1.6
left: Thymidine 5'-triphosphate
left: Water
name: Thymidine 5'-triphosphate + Water → Phosphate + dTDP
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001096
type: UnificationXref
id: HMDB0001096
db: HMDB

2.1.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dTDP
spontaneous: false
EC number: 2.1.1.45
left: 5-Thymidylic acid
left: Adenosine triphosphate
name: 5-Thymidylic acid + Adenosine triphosphate ↔ Adenosine diphosphate + dTDP
conversion direction: REVERSIBLE

Reference/ChemSpider 37610
type: UnificationXref
id: 37610
db: ChemSpider

thioredoxin
type: SmallMolecule
cellular location: Cytosol
entity reference: thioredoxin

3.6.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: 5-Thymidylic acid
spontaneous: false
EC number: 3.6.1.6
left: dTDP
left: Water
name: Water + dTDP → 5-Thymidylic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

2.4.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000187 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000179 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001042 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Deoxyribose 1-phosphate
right: Thymine
spontaneous: false
EC number: 2.4.2.4
left: Phosphate
left: Thymidine
name: Phosphate + Thymidine → Deoxyribose 1-phosphate + Thymine
conversion direction: LEFT_TO_RIGHT

1.3.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000056 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000179 Cytosol/Stoichiometry/1.0
right: Dihydrothymine
right: NADPH
spontaneous: false
EC number: 1.3.1.2
left: Thymine
left: NADP
name: NADP + Thymine → Dihydrothymine + NADPH
conversion direction: LEFT_TO_RIGHT

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000187 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Thymidine
spontaneous: false
EC number: 3.1.3.5
left: 5-Thymidylic acid
left: Water
name: 5-Thymidylic acid + Water → Phosphate + Thymidine
conversion direction: LEFT_TO_RIGHT

2.7.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000187 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000950 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: 5-Thymidylic acid
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.21
left: Adenosine triphosphate
left: Thymidine
name: Adenosine triphosphate + Thymidine → 5-Thymidylic acid + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 64956
type: UnificationXref
id: 64956
db: PubChem-compound

3.6.1.19
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: Uridine 5'-monophosphate
spontaneous: false
EC number: 3.6.1.19
left: Uridine triphosphate
left: Water
name: Uridine triphosphate + Water → Pyrophosphate + Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000192 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

6.3.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000790 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: dCTP
right: Cytidine triphosphate
spontaneous: false
EC number: 6.3.4.2
left: Adenosine triphosphate
left: Uridine triphosphate
name: Adenosine triphosphate + Uridine triphosphate → Adenosine diphosphate + Cytidine triphosphate + Phosphate + dCTP
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00239
type: UnificationXref
id: C00239
db: KEGG Compound

3.6.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
right: Phosphoric acid
right: Uridine 5'-diphosphate
spontaneous: false
EC number: 3.6.1.6
left: Uridine triphosphate
left: Water
name: Uridine triphosphate + Water → Phosphoric acid + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

2.7.4.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001918 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Uridine triphosphate
right: 3'-AMP
spontaneous: false
EC number: 2.7.4.10
left: Adenosine diphosphate
left: Uridine 5'-diphosphate
name: Adenosine diphosphate + Uridine 5'-diphosphate → 3'-AMP + Uridine triphosphate
conversion direction: LEFT_TO_RIGHT

Carbamoyl phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 278
xref: Reference/BioCyc CARBAMOYL-P
xref: Reference/ChemSpider 272
xref: Reference/HMDB HMDB0001096
xref: Reference/CAS 590-55-6
xref: Reference/KEGG Compound C00169
xref: Reference/ChEBI CHEBI 17672
chemical formula: CH4NO5P
molecular weight: 140.98271
structure: ChemicalStructure/PW C000862

Quinone
type: SmallMolecule
cellular location: Cytosol
entity reference: Quinone

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Compound/PW C000064 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00475
type: UnificationXref
id: C00475
db: KEGG Compound

Compound/PW C001146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

1.3.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/Generic52 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001852 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001860 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000151 Cytosol/Stoichiometry/1.0
right: quinol
right: Orotic acid
spontaneous: false
EC number: 1.3.5.2
left: Quinone
left: L-Dihydroorotic acid
name: L-Dihydroorotic acid + Quinone → Orotic acid + quinol
conversion direction: LEFT_TO_RIGHT

Reaction110301
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000151 Cytosol/Stoichiometry/1.0
right: Orotidylic acid
spontaneous: false
left: Phosphoribosyl pyrophosphate
left: Orotic acid
name: Orotic acid + Phosphoribosyl pyrophosphate ↔ Orotidylic acid
conversion direction: REVERSIBLE

Reaction110304
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Uridine 5'-diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Uridine 5'-monophosphate
name: Adenosine triphosphate + Uridine 5'-monophosphate → Adenosine diphosphate + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: Uridine 5'-diphosphate
spontaneous: false
EC number: 2.7.4.6
left: Adenosine diphosphate
left: Uridine triphosphate
name: Adenosine diphosphate + Uridine triphosphate ↔ Adenosine triphosphate + Uridine 5'-diphosphate
conversion direction: REVERSIBLE

Reaction110302
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000144 Cytosol/Stoichiometry/1.0
right: Uridine 5'-monophosphate
spontaneous: false
left: Orotidylic acid
name: Orotidylic acid → Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

3.6.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Uridine 5'-monophosphate
spontaneous: false
EC number: 3.6.1.6
left: Uridine 5'-diphosphate
left: Water
name: Uridine 5'-diphosphate + Water → Phosphate + Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

3.5.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000018 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000053 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ureidopropionic acid
spontaneous: false
EC number: 3.5.2.2
left: Dihydrouracil
left: Water
name: Dihydrouracil + Water → Ureidopropionic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

2.4.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000204 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000202 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Uracil
right: Ribose 1-phosphate
spontaneous: false
EC number: 2.4.2.3
left: Phosphate
left: Uridine
name: Phosphate + Uridine → Ribose 1-phosphate + Uracil
conversion direction: LEFT_TO_RIGHT

1.3.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000204 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000053 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Dihydrouracil
right: NADPH
spontaneous: false
EC number: 1.3.1.2
left: Uracil
left: NADP
name: NADP + Uracil → Dihydrouracil + NADPH
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: CDP
spontaneous: false
EC number: 2.7.4.6
left: Adenosine diphosphate
left: Cytidine triphosphate
name: Adenosine diphosphate + Cytidine triphosphate ↔ Adenosine triphosphate + CDP
conversion direction: REVERSIBLE

3.6.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000064 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Cytidine monophosphate
spontaneous: false
EC number: 3.6.1.6
left: CDP
left: Water
name: CDP + Water → Cytidine monophosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

3.6.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: CDP
spontaneous: false
EC number: 3.6.1.6
left: Cytidine triphosphate
left: Water
name: Cytidine triphosphate + Water → CDP + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000927 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyuridine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000201 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

3.5.4.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000202 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000061 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Uridine
spontaneous: false
EC number: 3.5.4.3
left: Cytidine
left: Water
name: Cytidine + Water → Ammonia + Uridine
conversion direction: LEFT_TO_RIGHT

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000202 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Uridine
spontaneous: false
EC number: 3.1.3.5
left: Uridine 5'-monophosphate
left: Water
name: Uridine 5'-monophosphate + Water → Phosphate + Uridine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 93072
type: UnificationXref
id: 93072
db: PubChem-compound

Reaction110313
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: Cytidine monophosphate
spontaneous: false
left: Adenosine diphosphate
left: CDP
name: Adenosine diphosphate + CDP ↔ Adenosine triphosphate + Cytidine monophosphate
conversion direction: REVERSIBLE

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000061 Cytosol/Stoichiometry/1.0
right: Phosphoric acid
right: Cytidine
spontaneous: false
EC number: 3.1.3.5
left: Cytidine monophosphate
left: Water
name: Cytidine monophosphate + Water → Cytidine + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000414 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Reference/KEGG Compound C01346
type: UnificationXref
id: C01346
db: KEGG Compound

Reference/KEGG Compound C01103
type: UnificationXref
id: C01103
db: KEGG Compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Compound/PW C000190 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 58574
type: UnificationXref
id: 58574
db: ChemSpider

Compound/PW C000056 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrothymine
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/ChemSpider 388420
type: UnificationXref
id: 388420
db: ChemSpider

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Dihydropyrimidinase-related protein 5
type: Protein
cellular location: Cytosol
entity reference: Dihydropyrimidinase-related protein 5

Reference/CAS 3432-99-3
type: UnificationXref
id: 3432-99-3
db: CAS

Thioredoxin domain-containing protein 3
type: ProteinReference
xref: Reference/UniProt Q715T0
organism: Mus musculus

Compound/PW C000057 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/CAS 504-07-4
type: UnificationXref
id: 504-07-4
db: CAS

Reference/KEGG Compound C01367
type: UnificationXref
id: C01367
db: KEGG Compound

Reference/ChemSpider 128553
type: UnificationXref
id: 128553
db: ChemSpider

Reference/HMDB HMDB0001227
type: UnificationXref
id: HMDB0001227
db: HMDB

ChemicalStructure/PW C000179
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CNC(=O)NC1=O

Reference/PubChem-compound 98792
type: UnificationXref
id: 98792
db: PubChem-compound

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000187
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc DIHYDROFOLATE
type: UnificationXref
id: DIHYDROFOLATE
db: BioCyc

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

ChemicalStructure/PW C001035
type: ChemicalStructure
structure format: SMILES

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Compound/PW C000061 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine
stoichiometric coefficient: 1.0

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/ChemSpider 5902
type: UnificationXref
id: 5902
db: ChemSpider

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

Reference/KEGG Compound C00295
type: UnificationXref
id: C00295
db: KEGG Compound

Reference/KEGG Compound C00299
type: UnificationXref
id: C00299
db: KEGG Compound

Compound/Generic52 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: quinol
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001245
type: UnificationXref
id: HMDB0001245
db: HMDB

Reference/HMDB HMDB0001489
type: UnificationXref
id: HMDB0001489
db: HMDB

ChemicalStructure/PW C000151
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC(=O)NC(=O)N1

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Reference/PubChem-compound 145729
type: UnificationXref
id: 145729
db: PubChem-compound

5,10-Methylene-THF
type: SmallMolecule
cellular location: Cytosol
entity reference: 5,10-Methylene-THF

Reference/HMDB HMDB0001000
type: UnificationXref
id: HMDB0001000
db: HMDB

Reference/BioCyc DUDP
type: UnificationXref
id: DUDP
db: BioCyc

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

Reference/ChEBI CHEBI 18261
type: UnificationXref
id: CHEBI:18261
db: ChEBI

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/CAS 4033-27-6
type: UnificationXref
id: 4033-27-6
db: CAS

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

Ureidopropionic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ureidopropionic acid

Reference/CAS 58-96-8
type: UnificationXref
id: 58-96-8
db: CAS

3-Aminoisobutanoic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27389
xref: Reference/KEGG Compound C05145
xref: Reference/BioCyc 3-AMINO-ISOBUTYRATE
xref: Reference/CAS 144-90-1
xref: Reference/HMDB HMDB0003911
xref: Reference/ChemSpider 58481
xref: Reference/PubChem-compound 64956
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C001993

Ureidosuccinic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00438
xref: Reference/CAS 13184-27-5
xref: Reference/BioCyc CARBAMYUL-L-ASPARTATE
xref: Reference/ChEBI CHEBI 15859
xref: Reference/ChemSpider 84022
xref: Reference/HMDB HMDB0000828
xref: Reference/PubChem-compound 93072
chemical formula: C5H8N2O5
molecular weight: 176.04332
structure: ChemicalStructure/PW C000662

Reference/PubChem-compound 41211
type: UnificationXref
id: 41211
db: PubChem-compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000007 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyuridine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 967
type: UnificationXref
id: 967
db: PubChem-compound

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Reference/ChEBI CHEBI 18077
type: UnificationXref
id: CHEBI:18077
db: ChEBI

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/ChEBI CHEBI 18075
type: UnificationXref
id: CHEBI:18075
db: ChEBI

Reference/PubChem-compound 13712
type: UnificationXref
id: 13712
db: PubChem-compound

Reference/PubChem-compound 13711
type: UnificationXref
id: 13711
db: PubChem-compound

Reference/CAS 951-77-9
type: UnificationXref
id: 951-77-9
db: CAS

Soluble calcium-activated nucleotidase 1
type: Protein
cellular location: Cytosol
entity reference: Soluble calcium-activated nucleotidase 1

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/PubChem-compound 6175
type: UnificationXref
id: 6175
db: PubChem-compound

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Reference/PubChem-compound 13945
type: UnificationXref
id: 13945
db: PubChem-compound

Reference/BioCyc THYMINE
type: UnificationXref
id: THYMINE
db: BioCyc

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate
name: SubPathwayInput

Reference/HMDB HMDB0001274
type: UnificationXref
id: HMDB0001274
db: HMDB

Reference/ChemSpider 1103
type: UnificationXref
id: 1103
db: ChemSpider

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChemSpider 84456
type: UnificationXref
id: 84456
db: ChemSpider

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Uracil
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17568
xref: Reference/KEGG Compound C00106
xref: Reference/HMDB HMDB0000300
xref: Reference/CAS 66-22-8
xref: Reference/BioCyc URACIL
xref: Reference/PubChem-compound 1174
xref: Reference/ChemSpider 1141
chemical formula: C4H4N2O2
molecular weight: 112.027275
structure: ChemicalStructure/PW C000204

Uridine
type: SmallMoleculeReference
xref: Reference/CAS 58-96-8
xref: Reference/ChEBI CHEBI 16704
xref: Reference/PubChem-compound 6029
xref: Reference/ChemSpider 5807
xref: Reference/BioCyc URIDINE
xref: Reference/HMDB HMDB0000296
xref: Reference/KEGG Compound C00299
chemical formula: C9H12N2O6
molecular weight: 244.06953
structure: ChemicalStructure/PW C000202

Reference/KEGG Compound C00099
type: UnificationXref
id: C00099
db: KEGG Compound

Reference/ChemSpider 5940
type: UnificationXref
id: 5940
db: ChemSpider

Carbamoyl phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbamoyl phosphate
name: SubPathwayOutput

ChemicalStructure/PW C001042
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(C[C@@H]1O)OP(O)(O)=O

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000194
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc DEOXYCYTIDINE
type: UnificationXref
id: DEOXYCYTIDINE
db: BioCyc

Reference/BioCyc UMP
type: UnificationXref
id: UMP
db: BioCyc

Reference/ChemSpider 629
type: UnificationXref
id: 629
db: ChemSpider

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Dihydropyrimidinase Deficiency
type: Pathway
pathway order: PathwayEnzymeReaction/2111592
pathway order: PathwaySubPathway/108033
pathway order: PathwayEnzymeReaction/2111591
pathway order: PathwaySubPathway/108034
pathway order: PathwayEnzymeReaction/2111550
pathway order: PathwayEnzymeReaction/2111594
pathway order: PathwaySubPathway/108035
pathway order: PathwayEnzymeReaction/2111593
pathway order: PathwaySubPathway/108036
pathway order: PathwayEnzymeReaction/2111552
pathway order: PathwayEnzymeReaction/2111551
pathway order: PathwayEnzymeReaction/2111554
pathway order: PathwayEnzymeReaction/2111553
pathway order: PathwaySubPathway/108032
pathway order: PathwayEnzymeReaction/2111556
pathway order: PathwayEnzymeReaction/2111555
pathway order: PathwayEnzymeReaction/2111558
pathway order: PathwayEnzymeReaction/2111557
pathway order: PathwaySubPathway/108037
pathway order: PathwayEnzymeReaction/2111559
pathway order: PathwaySubPathway/108038
pathway order: PathwayEnzymeReaction/2111590
pathway order: PathwayEnzymeReaction/2111581
pathway order: PathwayEnzymeReaction/2111580
pathway order: PathwayEnzymeReaction/2111583
pathway order: PathwayEnzymeReaction/2111582
pathway order: PathwayEnzymeReaction/2111585
pathway order: PathwayEnzymeReaction/2111584
pathway order: PathwayEnzymeReaction/2111587
pathway order: PathwayEnzymeReaction/2111586
pathway order: PathwayEnzymeReaction/2111545
pathway order: PathwayEnzymeReaction/2111589
pathway order: PathwayEnzymeReaction/2111588
pathway order: PathwayEnzymeReaction/2111547
pathway order: PathwayEnzymeReaction/2111546
pathway order: PathwayEnzymeReaction/2111549
pathway order: PathwayEnzymeReaction/2111548
pathway order: PathwayEnzymeReaction/2111570
pathway order: PathwayEnzymeReaction/2111572
pathway order: PathwayEnzymeReaction/2111571
pathway order: PathwayEnzymeReaction/2111574
pathway order: PathwayEnzymeReaction/2111573
pathway order: PathwayEnzymeReaction/2111576
pathway order: PathwayEnzymeReaction/2111575
pathway order: PathwayEnzymeReaction/2111578
pathway order: PathwayEnzymeReaction/2111577
pathway order: PathwayEnzymeReaction/2111579
pathway order: PathwayEnzymeReaction/2111561
pathway order: PathwayEnzymeReaction/2111560
pathway order: PathwayEnzymeReaction/2111563
pathway order: PathwayEnzymeReaction/2111562
pathway order: PathwayEnzymeReaction/2111565
pathway order: PathwayEnzymeReaction/2111564
pathway order: PathwayEnzymeReaction/2111567
pathway order: PathwayEnzymeReaction/2111566
pathway order: PathwayEnzymeReaction/2111569
pathway order: PathwayEnzymeReaction/2111568
pathway component: ReactionCatalysis100609
pathway component: RNA reaction
pathway component: Valine, Leucine, and Isoleucine Degradation
pathway component: Pentose Phosphate Pathway
pathway component: 3.5.1.6
pathway component: 3.6.1.23
pathway component: ReactionCatalysis100616
pathway component: 1.17.4.1
pathway component: ReactionCatalysis100615
pathway component: 2.7.1.48
pathway component: ReactionCatalysis100614
pathway component: 2.7.4.6
pathway component: ReactionCatalysis100613
pathway component: 2.1.1.45
pathway component: ReactionCatalysis100612
pathway component: ReactionCatalysis100611
pathway component: ReactionCatalysis100610
pathway component: 3.5.4.12
pathway component: 2.7.1.21
pathway component: ReactionCatalysis100629
pathway component: ReactionCatalysis100628

Reference/UniProt Q9EQF6
type: UnificationXref
id: Q9EQF6
db: UniProt

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Reference/HMDB HMDB0001056
type: UnificationXref
id: HMDB0001056
db: HMDB

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/CAS 1032-65-1
type: UnificationXref
id: 1032-65-1
db: CAS

Reference/PubChem-compound 1135
type: UnificationXref
id: 1135
db: PubChem-compound

ChemicalStructure/PW C000204
type: ChemicalStructure
structure format: SMILES
structure data: O=C1NC=CC(=O)N1

Compound/PW C000008 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxycytidine
stoichiometric coefficient: 1.0

Ureidoisobutyric acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 141172
xref: Reference/KEGG Compound C05100
xref: Reference/ChEBI CHEBI 1670
xref: Reference/BioCyc 3-UREIDO-ISOBUTYRATE
xref: Reference/HMDB HMDB0002031
xref: Reference/CAS 2905-86-4
xref: Reference/PubChem-compound 160663
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C001363

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/UniProt Q8CHR6
type: UnificationXref
id: Q8CHR6
db: UniProt

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Reference/PubChem-compound 111
type: UnificationXref
id: 111
db: PubChem-compound

Reference/HMDB HMDB0000300
type: UnificationXref
id: HMDB0000300
db: HMDB

Reference/KEGG Compound C05100
type: UnificationXref
id: C05100
db: KEGG Compound

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

β-Alanine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000056
xref: Reference/ChemSpider 234
xref: Reference/PubChem-compound 239
xref: Reference/ChEBI CHEBI 16958
xref: Reference/KEGG Compound C00099
xref: Reference/CAS 107-95-9
xref: Reference/BioCyc B-ALANINE
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000040

Deoxycytidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15698
xref: Reference/HMDB HMDB0000014
xref: Reference/CAS 951-77-9
xref: Reference/KEGG Compound C00881
xref: Reference/PubChem-compound 13711
xref: Reference/ChemSpider 13117
xref: Reference/BioCyc DEOXYCYTIDINE
chemical formula: C9H13N3O4
molecular weight: 227.0906
structure: ChemicalStructure/PW C000008

Deoxyuridine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00526
xref: Reference/HMDB HMDB0000012
xref: Reference/BioCyc DEOXYURIDINE
xref: Reference/PubChem-compound 13712
xref: Reference/ChemSpider 13118
xref: Reference/ChEBI CHEBI 16450
xref: Reference/CAS 951-78-0
chemical formula: C9H12N2O5
molecular weight: 228.07462
structure: ChemicalStructure/PW C000007

Reference/CAS 696-04-8
type: UnificationXref
id: 696-04-8
db: CAS

Uridine 5'-monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-monophosphate

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChemSpider 272
type: UnificationXref
id: 272
db: ChemSpider

Reference/CAS 4208-67-7
type: UnificationXref
id: 4208-67-7
db: CAS

Reference/BioCyc DUMP
type: UnificationXref
id: DUMP
db: BioCyc

Compound/PW C000151 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 141140
type: UnificationXref
id: 141140
db: ChemSpider

Ureidopropionic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000026
xref: Reference/CAS 462-88-4
xref: Reference/KEGG Compound C02642
xref: Reference/ChEBI CHEBI 18261
xref: Reference/PubChem-compound 111
xref: Reference/ChemSpider 109
xref: Reference/BioCyc 3-UREIDO-PROPIONATE
chemical formula: C4H8N2O3
molecular weight: 132.0535
structure: ChemicalStructure/PW C000018

Compound/PW C000144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotidylic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/HMDB HMDB0001409
type: UnificationXref
id: HMDB0001409
db: HMDB

Reference/BioCyc DI-H-URACIL
type: UnificationXref
id: DI-H-URACIL
db: BioCyc

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

Cytidine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Cytidine monophosphate

ChemicalStructure/PW C000202
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00906
type: UnificationXref
id: C00906
db: KEGG Compound

Thioredoxin domain-containing protein 3
type: Protein
cellular location: Cytosol
entity reference: Thioredoxin domain-containing protein 3

Reference/ChemSpider 141172
type: UnificationXref
id: 141172
db: ChemSpider

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000053 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrouracil
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000008
type: ChemicalStructure
structure format: SMILES

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

ChemicalStructure/PW C000007
type: ChemicalStructure
structure format: SMILES

Compound/PW C000179 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thymine
stoichiometric coefficient: 1.0

Dihydrothymine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrothymine

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/ChEBI CHEBI 28846
type: UnificationXref
id: CHEBI:28846
db: ChEBI

Reference/BioCyc CYTIDINE
type: UnificationXref
id: CYTIDINE
db: BioCyc

dUMP
type: SmallMolecule
cellular location: Cytosol
entity reference: dUMP

Compound/PW C000962 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCDP
stoichiometric coefficient: 1.0

Compound/PW C000194 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-monophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

ChemicalStructure/PW C000018
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCNC(O)=N

Reference/BioCyc 3-UREIDO-PROPIONATE
type: UnificationXref
id: 3-UREIDO-PROPIONATE
db: BioCyc

Reference/KEGG Compound C05145
type: UnificationXref
id: C05145
db: KEGG Compound

Reference/BioCyc 3-AMINO-ISOBUTYRATE
type: UnificationXref
id: 3-AMINO-ISOBUTYRATE
db: BioCyc

5,10-Methylene-THF
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001533
xref: Reference/CAS 3432-99-3
xref: Reference/PubChem-compound 439175
xref: Reference/ChEBI CHEBI 15636
xref: Reference/KEGG Compound C00143
xref: Reference/BioCyc METHYLENE-THF
xref: Reference/ChemSpider 388320
chemical formula: C20H23N7O6
molecular weight: 457.171
structure: ChemicalStructure/PW C001178

thioredoxin disulfide
type: SmallMolecule
cellular location: Cytosol
entity reference: thioredoxin disulfide

Reference/SMPDB SMP0000059
type: UnificationXref
id: SMP0000059
db: SMPDB

Compound/PW C001042 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyribose 1-phosphate
stoichiometric coefficient: 1.0

Dihydrouracil
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrouracil

Reference/SMPDB SMP0000055
type: UnificationXref
id: SMP0000055
db: SMPDB

Compound/PW C001035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thymidine 5'-triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/ChemSpider 234
type: UnificationXref
id: 234
db: ChemSpider

Reference/HMDB HMDB0001202
type: UnificationXref
id: HMDB0001202
db: HMDB

Ribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 14075-00-4
xref: Reference/ChEBI CHEBI 16300
xref: Reference/HMDB HMDB0001489
xref: Reference/PubChem-compound 439236
xref: Reference/ChemSpider 388373
xref: Reference/BioCyc RIBOSE-1P
xref: Reference/KEGG Compound C00620
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001146

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Dihydrothymine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000079
xref: Reference/ChEBI CHEBI 27468
xref: Reference/BioCyc DIHYDRO-THYMINE
xref: Reference/ChemSpider 84456
xref: Reference/CAS 696-04-8
xref: Reference/PubChem-compound 93556
xref: Reference/KEGG Compound C00906
chemical formula: C5H8N2O2
molecular weight: 128.05858
structure: ChemicalStructure/PW C000056

Dihydrouracil
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00429
xref: Reference/ChEBI CHEBI 15901
xref: Reference/ChemSpider 629
xref: Reference/PubChem-compound 649
xref: Reference/CAS 504-07-4
xref: Reference/BioCyc DI-H-URACIL
xref: Reference/HMDB HMDB0000076
chemical formula: C4H6N2O2
molecular weight: 114.04293
structure: ChemicalStructure/PW C000053

Reference/KEGG Compound C00705
type: UnificationXref
id: C00705
db: KEGG Compound

Reference/BioCyc CARBAMYUL-L-ASPARTATE
type: UnificationXref
id: CARBAMYUL-L-ASPARTATE
db: BioCyc

Cytidine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000089
xref: Reference/PubChem-compound 6175
xref: Reference/BioCyc CYTIDINE
xref: Reference/ChemSpider 5940
xref: Reference/CAS 65-46-3
xref: Reference/KEGG Compound C00475
xref: Reference/ChEBI CHEBI 17562
chemical formula: C9H13N3O5
molecular weight: 243.08553
structure: ChemicalStructure/PW C000061

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Reference/BioCyc OROTIDINE-5-PHOSPHATE
type: UnificationXref
id: OROTIDINE-5-PHOSPHATE
db: BioCyc

Reference/ChEBI CHEBI 17748
type: UnificationXref
id: CHEBI:17748
db: ChEBI

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

CAD protein
type: Protein
cellular location: Cytosol
entity reference: CAD protein

Reference/BioCyc DIHYDRO-THYMINE
type: UnificationXref
id: DIHYDRO-THYMINE
db: BioCyc

Reference/PubChem-compound 93556
type: UnificationXref
id: 93556
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/BioCyc B-ALANINE
type: UnificationXref
id: B-ALANINE
db: BioCyc

Deoxyuridine
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxyuridine

Reference/PubChem-compound 65063
type: UnificationXref
id: 65063
db: PubChem-compound

Reference/PubChem-compound 65070
type: UnificationXref
id: 65070
db: PubChem-compound

ChemicalStructure/PW C000862
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)OP(O)(O)=O

Compound/PW C000831 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrofolic acid
stoichiometric coefficient: 1.0

Uridine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine triphosphate
name: SubPathwayInput

Uridine
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine

ChemicalStructure/PW C001918
type: ChemicalStructure
structure format: SMILES

Cytosolic purine 5'-nucleotidase
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

CDP
type: SmallMolecule
cellular location: Cytosol
entity reference: CDP
name: SubPathwayInput

CDP
type: SmallMoleculeReference
xref: Reference/ChemSpider 5902
xref: Reference/PubChem-compound 6132
xref: Reference/HMDB HMDB0001546
xref: Reference/ChEBI CHEBI 17239
xref: Reference/BioCyc CDP
xref: Reference/CAS 63-38-7
xref: Reference/KEGG Compound C00112
chemical formula: C9H15N3O11P2
molecular weight: 403.0182
structure: ChemicalStructure/PW C001189

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 9700
type: UnificationXref
id: 9700
db: PubChem-compound

ChemicalStructure/PW C000831
type: ChemicalStructure
structure format: SMILES

Compound/PW C001034 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

Reference/PubChem-compound 65091
type: UnificationXref
id: 65091
db: PubChem-compound

Reference/BioCyc DUTP
type: UnificationXref
id: DUTP
db: BioCyc

Compound/PW C001852 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dihydroorotic acid
stoichiometric coefficient: 1.0

Reaction110297
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Carbamoyl phosphate
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
left: L-Glutamine
left: Adenosine triphosphate
left: Hydrogen carbonate
left: Water
name: 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

β-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: β-Alanine
name: SubPathwayInput

Reaction110298
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000662 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862 Cytosol/Stoichiometry/1.0
right: Ureidosuccinic acid
spontaneous: false
left: Carbamoyl phosphate
name: Carbamoyl phosphate → Ureidosuccinic acid
conversion direction: LEFT_TO_RIGHT

Reaction110299
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001852 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000662 Cytosol/Stoichiometry/1.0
right: L-Dihydroorotic acid
spontaneous: false
left: Ureidosuccinic acid
name: Ureidosuccinic acid → L-Dihydroorotic acid
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0000032
type: UnificationXref
id: SMP0000032
db: SMPDB

Reference/ChEBI CHEBI 28850
type: UnificationXref
id: CHEBI:28850
db: ChEBI

Reference/SMPDB SMP0000031
type: UnificationXref
id: SMP0000031
db: SMPDB

Compound/PW C000018 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ureidopropionic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

dCTP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCTP
name: SubPathwayInput

Protein/Generic27 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioredoxin disulfide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1174
type: UnificationXref
id: 1174
db: PubChem-compound

Reference/ChEBI CHEBI 16450
type: UnificationXref
id: CHEBI:16450
db: ChEBI

Deoxyuridine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxyuridine triphosphate

Reference/ChEBI CHEBI 16695
type: UnificationXref
id: CHEBI:16695
db: ChEBI

Ureidoisobutyric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ureidoisobutyric acid

Compound/PW C001993 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Aminoisobutanoic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00526
type: UnificationXref
id: C00526
db: KEGG Compound

Soluble calcium-activated nucleotidase 1
type: ProteinReference
xref: Reference/UniProt Q8VCF1
organism: Mus musculus

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C000040 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-Alanine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000662
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)N[C@@H](CC(O)=O)C(O)=O

ChemicalStructure/PW C001993
type: ChemicalStructure
structure format: SMILES
structure data: CC(CN)C(O)=O

Reference/BioCyc 3-UREIDO-ISOBUTYRATE
type: UnificationXref
id: 3-UREIDO-ISOBUTYRATE
db: BioCyc

Reference/PathWhiz PW000001
type: UnificationXref
id: PW000001
db: PathWhiz

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine
name: SubPathwayInput

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

Reference/ChemSpider 89228
type: UnificationXref
id: 89228
db: ChemSpider

Reference/ChemSpider 388373
type: UnificationXref
id: 388373
db: ChemSpider

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Reference/UniProt Q8VCF1
type: UnificationXref
id: Q8VCF1
db: UniProt

Reference/HMDB HMDB0000998
type: UnificationXref
id: HMDB0000998
db: HMDB

Orotic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Orotic acid

Ribose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Ribose 1-phosphate

Reference/PubChem-compound 5789
type: UnificationXref
id: 5789
db: PubChem-compound

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Reference/BioCyc DEOXYURIDINE
type: UnificationXref
id: DEOXYURIDINE
db: BioCyc

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

ReactionCatalysis100609
type: Catalysis
controller: CAD protein
controlled: Reaction110297
control type: ACTIVATION

Reference/CAS 365-07-1
type: UnificationXref
id: 365-07-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 6029
type: UnificationXref
id: 6029
db: PubChem-compound

Reference/ChemSpider 388355
type: UnificationXref
id: 388355
db: ChemSpider

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

ReactionCatalysis100616
type: Catalysis
controller: Unknown
controlled: Reaction110304
control type: ACTIVATION

ReactionCatalysis100615
type: Catalysis
controller: Soluble calcium-activated nucleotidase 1
controlled: 3.6.1.6
control type: ACTIVATION

Reference/HMDB HMDB0002031
type: UnificationXref
id: HMDB0002031
db: HMDB

ReactionCatalysis100614
type: Catalysis
controller: Unknown
controlled: Reaction110302
control type: ACTIVATION

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

ReactionCatalysis100613
type: Catalysis
controller: Unknown
controlled: Reaction110301
control type: ACTIVATION

ReactionCatalysis100612
type: Catalysis
controller: Unknown
controlled: 1.3.5.2
control type: ACTIVATION

ReactionCatalysis100611
type: Catalysis
controller: CAD protein
controlled: Reaction110299
control type: ACTIVATION

ReactionCatalysis100610
type: Catalysis
controller: CAD protein
controlled: Reaction110298
control type: ACTIVATION

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Reference/PathWhiz PW000055
type: UnificationXref
id: PW000055
db: PathWhiz

Reference/ChEBI CHEBI 17239
type: UnificationXref
id: CHEBI:17239
db: ChEBI

Reference/HMDB HMDB0001191
type: UnificationXref
id: HMDB0001191
db: HMDB

5-Thymidylic acid
type: SmallMoleculeReference
xref: Reference/BioCyc TMP
xref: Reference/PubChem-compound 9700
xref: Reference/HMDB HMDB0001227
xref: Reference/ChemSpider 9319
xref: Reference/CAS 365-07-1
xref: Reference/KEGG Compound C00364
xref: Reference/ChEBI CHEBI 17013
chemical formula: C10H15N2O8P
molecular weight: 322.0566
structure: ChemicalStructure/PW C000950

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PathWhiz PW000051
type: UnificationXref
id: PW000051
db: PathWhiz

Compound/PW C000662 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ureidosuccinic acid
stoichiometric coefficient: 1.0

3-Aminoisobutanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Aminoisobutanoic acid
name: SubPathwayOutput

Reference/KEGG Compound C00337
type: UnificationXref
id: C00337
db: KEGG Compound

ReactionCatalysis100629
type: Catalysis
controller: Unknown
controlled: 2.4.2.3
control type: ACTIVATION

ReactionCatalysis100628
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

CAD protein
type: ProteinReference
xref: Reference/UniProt B2RQC6
organism: Mus musculus

Deoxyuridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 65070
xref: Reference/BioCyc DUTP
xref: Reference/CAS 1173-82-6
xref: Reference/HMDB HMDB0001191
xref: Reference/ChEBI CHEBI 17625
xref: Reference/KEGG Compound C00460
xref: Reference/ChemSpider 58580
chemical formula: C9H15N2O14P3
molecular weight: 467.9736
structure: ChemicalStructure/PW C000927

Reference/ChemSpider 58481
type: UnificationXref
id: 58481
db: ChemSpider

ReactionCatalysis100630
type: Catalysis
controller: Dihydropyrimidine dehydrogenase [NADP(+)]
controlled: 1.3.1.2
control type: ACTIVATION

ReactionCatalysis100638
type: Catalysis
controller: Unknown
controlled: 3.5.4.5
control type: ACTIVATION

ReactionCatalysis100637
type: Catalysis
controller: Unknown
controlled: 2.7.1.48
control type: ACTIVATION

ReactionCatalysis100636
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

ReactionCatalysis100635
type: Catalysis
controller: Unknown
controlled: Reaction110323
control type: ACTIVATION

ReactionCatalysis100634
type: Catalysis
controller: Thioredoxin domain-containing protein 3
controlled: 2.7.4.6
control type: ACTIVATION

ReactionCatalysis100633
type: Catalysis
controller: Ribonucleoside-diphosphate reductase large subunit
controlled: 1.17.4.1
control type: ACTIVATION

ReactionCatalysis100632
type: Catalysis
controller: Beta-ureidopropionase
controlled: 3.5.1.6
control type: ACTIVATION

ReactionCatalysis100631
type: Catalysis
controller: Dihydropyrimidinase
controlled: 3.5.2.2
control type: ACTIVATION

Reference/KEGG Compound C00106
type: UnificationXref
id: C00106
db: KEGG Compound

Reference/KEGG Compound C00105
type: UnificationXref
id: C00105
db: KEGG Compound

Reference/PubChem-compound 6030
type: UnificationXref
id: 6030
db: PubChem-compound

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

ReactionCatalysis100619
type: Catalysis
controller: Unknown
controlled: 2.7.4.10
control type: ACTIVATION

ReactionCatalysis100618
type: Catalysis
controller: Soluble calcium-activated nucleotidase 1
controlled: 3.6.1.6
control type: ACTIVATION

ReactionCatalysis100617
type: Catalysis
controller: Thioredoxin domain-containing protein 3
controlled: 2.7.4.6
control type: ACTIVATION

Reference/CAS 800-73-7
type: UnificationXref
id: 800-73-7
db: CAS

Reference/BioCyc METHYLENE-THF
type: UnificationXref
id: METHYLENE-THF
db: BioCyc

Reference/ChemSpider 58493
type: UnificationXref
id: 58493
db: ChemSpider

dCMP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00239
xref: Reference/HMDB HMDB0001202
xref: Reference/CAS 1032-65-1
xref: Reference/BioCyc DCMP
xref: Reference/PubChem-compound 13945
xref: Reference/ChemSpider 13343
xref: Reference/ChEBI CHEBI 15918
chemical formula: C9H14N3O7P
molecular weight: 307.05695
structure: ChemicalStructure/PW C000937

Reference/ChemSpider 942
type: UnificationXref
id: 942
db: ChemSpider

Reference/ChEBI CHEBI 15033
type: UnificationXref
id: CHEBI:15033
db: ChEBI

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-diphosphate
name: SubPathwayInput

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/PubChem-compound 439287
type: UnificationXref
id: 439287
db: PubChem-compound

ReactionCatalysis100627
type: Catalysis
controller: Guanine deaminase
controlled: 3.5.4.3
control type: ACTIVATION

ReactionCatalysis100626
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

ReactionCatalysis100625
type: Catalysis
controller: Unknown
controlled: Reaction110313
control type: ACTIVATION

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

ReactionCatalysis100624
type: Catalysis
controller: Soluble calcium-activated nucleotidase 1
controlled: 3.6.1.6
control type: ACTIVATION

ReactionCatalysis100623
type: Catalysis
controller: Thioredoxin domain-containing protein 3
controlled: 2.7.4.6
control type: ACTIVATION

ReactionCatalysis100622
type: Catalysis
controller: Soluble calcium-activated nucleotidase 1
controlled: 3.6.1.6
control type: ACTIVATION

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

ReactionCatalysis100621
type: Catalysis
controller: Unknown
controlled: 6.3.4.2
control type: ACTIVATION

ReactionCatalysis100620
type: Catalysis
controller: Inosine triphosphate pyrophosphatase
controlled: 3.6.1.19
control type: ACTIVATION

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Reference/BioCyc THYMIDINE
type: UnificationXref
id: THYMIDINE
db: BioCyc

Reference/PubChem-compound 160617
type: UnificationXref
id: 160617
db: PubChem-compound

ChemicalStructure/PW C000927
type: ChemicalStructure
structure format: SMILES

dTDP
type: SmallMoleculeReference
xref: Reference/CAS 491-97-4
xref: Reference/ChemSpider 144320
xref: Reference/PubChem-compound 164628
xref: Reference/KEGG Compound C00363
xref: Reference/ChEBI CHEBI 18075
xref: Reference/HMDB HMDB0001274
xref: Reference/BioCyc TDP
chemical formula: C10H16N2O11P2
molecular weight: 402.02292
structure: ChemicalStructure/PW C000987

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChEBI CHEBI 17025
type: UnificationXref
id: CHEBI:17025
db: ChEBI

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00112
type: UnificationXref
id: C00112
db: KEGG Compound

Deoxyribose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxyribose 1-phosphate

Dihydropyrimidinase
type: Complex
component stoichiometry: Protein/13677 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Dihydropyrimidinase-related protein 5

dTDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dTDP

Reference/ChemSpider 13118
type: UnificationXref
id: 13118
db: ChemSpider

Reference/ChemSpider 13117
type: UnificationXref
id: 13117
db: ChemSpider

Compound/PW C001363 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ureidoisobutyric acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000937
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00364
type: UnificationXref
id: C00364
db: KEGG Compound

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/KEGG Compound C00363
type: UnificationXref
id: C00363
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/BioCyc DEOXY-RIBOSE-1P
type: UnificationXref
id: DEOXY-RIBOSE-1P
db: BioCyc

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00365
type: UnificationXref
id: C00365
db: KEGG Compound

Reference/ChemSpider 388320
type: UnificationXref
id: 388320
db: ChemSpider

Ureidosuccinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ureidosuccinic acid

Reference/CAS 65-86-1
type: UnificationXref
id: 65-86-1
db: CAS

dCDP
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001245
xref: Reference/ChemSpider 132961
xref: Reference/KEGG Compound C00705
xref: Reference/ChEBI CHEBI 28846
xref: Reference/CAS 800-73-7
xref: Reference/PubChem-compound 150855
xref: Reference/BioCyc DCDP
chemical formula: C9H15N3O10P2
molecular weight: 387.02325
structure: ChemicalStructure/PW C000962

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Inosine triphosphate pyrophosphatase
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/KEGG Compound C00143
type: UnificationXref
id: C00143
db: KEGG Compound

Compound/PW C001918 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3'-AMP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17013
type: UnificationXref
id: CHEBI:17013
db: ChEBI

Reference/CAS 5988-19-2
type: UnificationXref
id: 5988-19-2
db: CAS

Reference/ChemSpider 13343
type: UnificationXref
id: 13343
db: ChemSpider

Reference/BioCyc TTP
type: UnificationXref
id: TTP
db: BioCyc

Reference/UniProt B2RQC6
type: UnificationXref
id: B2RQC6
db: UniProt

Reference/CAS 462-88-4
type: UnificationXref
id: 462-88-4
db: CAS

Reference/BioCyc DCDP
type: UnificationXref
id: DCDP
db: BioCyc

RNA reaction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108034
pathway component: SubPathwayInteraction108034
name: SubPathway

Reference/HMDB HMDB0000012
type: UnificationXref
id: HMDB0000012
db: HMDB

Dihydropyrimidine dehydrogenase [NADP(+)]
type: Protein
cellular location: Cytosol
entity reference: Dihydropyrimidine dehydrogenase [NADP(+)]

ChemicalStructure/PW C000053
type: ChemicalStructure
structure format: SMILES
structure data: O=C1CCNC(=O)N1

Reference/HMDB HMDB0000014
type: UnificationXref
id: HMDB0000014
db: HMDB

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001146
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000056
type: ChemicalStructure
structure format: SMILES
structure data: CC1CNC(=O)NC1=O

Ribonucleoside-diphosphate reductase large subunit
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Unknown

Reference/PubChem-compound 649
type: UnificationXref
id: 649
db: PubChem-compound

dUDP
type: SmallMoleculeReference
xref: Reference/BioCyc DUDP
xref: Reference/PubChem-compound 145729
xref: Reference/CAS 4208-67-7
xref: Reference/KEGG Compound C01346
xref: Reference/HMDB HMDB0001000
xref: Reference/ChEBI CHEBI 28850
xref: Reference/ChemSpider 128553
chemical formula: C9H14N2O11P2
molecular weight: 388.0073
structure: ChemicalStructure/PW C000792

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

dCTP
type: SmallMoleculeReference
xref: Reference/CAS 2056-98-6
xref: Reference/PubChem-compound 65091
xref: Reference/ChEBI CHEBI 16311
xref: Reference/KEGG Compound C00458
xref: Reference/ChemSpider 58601
xref: Reference/HMDB HMDB0000998
xref: Reference/BioCyc DCTP
chemical formula: C9H16N3O13P3
molecular weight: 466.9896
structure: ChemicalStructure/PW C000790

Reference/HMDB HMDB0001342
type: UnificationXref
id: HMDB0001342
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

5-Thymidylic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Thymidylic acid

Protein/7725 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00169
type: UnificationXref
id: C00169
db: KEGG Compound

Reference/CAS 58-97-9
type: UnificationXref
id: 58-97-9
db: CAS

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000026
type: UnificationXref
id: HMDB0000026
db: HMDB

dCDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCDP

Reference/CAS 65-46-3
type: UnificationXref
id: 65-46-3
db: CAS

Reference/HMDB HMDB0001351
type: UnificationXref
id: HMDB0001351
db: HMDB

Reference/HMDB HMDB0000262
type: UnificationXref
id: HMDB0000262
db: HMDB

ChemicalStructure/PW C000061
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc DI-H-OROTATE
type: UnificationXref
id: DI-H-OROTATE
db: BioCyc

Reference/BioCyc URACIL
type: UnificationXref
id: URACIL
db: BioCyc

L-Dihydroorotic acid
type: SmallMoleculeReference
xref: Reference/CAS 5988-19-2
xref: Reference/KEGG Compound C00337
xref: Reference/BioCyc DI-H-OROTATE
xref: Reference/HMDB HMDB0003349
xref: Reference/PubChem-compound 439216
xref: Reference/ChEBI CHEBI 17025
xref: Reference/ChemSpider 388355
chemical formula: C5H6N2O4
molecular weight: 158.03276
structure: ChemicalStructure/PW C001852

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00178
type: UnificationXref
id: C00178
db: KEGG Compound

ChemicalStructure/PW C001363
type: ChemicalStructure
structure format: SMILES
structure data: CC(CNC(N)=O)C(O)=O

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 590-55-6
type: UnificationXref
id: 590-55-6
db: CAS

Reference/HMDB HMDB0000273
type: UnificationXref
id: HMDB0000273
db: HMDB

Reference/HMDB HMDB0003540
type: UnificationXref
id: HMDB0003540
db: HMDB

Reference/UniProt Q8VC97
type: UnificationXref
id: Q8VC97
db: UniProt

Thioredoxin
type: ProteinReference
xref: Reference/ChEBI CHEBI 15033
organism: Mus musculus

Reference/SMPDB SMP0120473
type: UnificationXref
id: SMP0120473
db: SMPDB

Thioredoxin disulfide
type: ProteinReference
xref: Reference/ChEBI CHEBI 18191
organism: Mus musculus

Reference/HMDB HMDB0000288
type: UnificationXref
id: HMDB0000288
db: HMDB

Dihydropyrimidine dehydrogenase [NADP(+)]
type: Complex
component stoichiometry: Protein/14178 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Dihydropyrimidine dehydrogenase [NADP(+)]

Reference/ChemSpider 132961
type: UnificationXref
id: 132961
db: ChemSpider

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

ChemicalStructure/PW C000040
type: ChemicalStructure
structure format: SMILES
structure data: NCCC(O)=O

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/BioCyc OROTATE
type: UnificationXref
id: OROTATE
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

ReactionCatalysis100652
type: Catalysis
controller: Beta-ureidopropionase
controlled: 3.5.1.6
control type: ACTIVATION

Reference/HMDB HMDB0000056
type: UnificationXref
id: HMDB0000056
db: HMDB

ReactionCatalysis100651
type: Catalysis
controller: Dihydropyrimidinase
controlled: 3.5.2.2
control type: ACTIVATION

ReactionCatalysis100650
type: Catalysis
controller: Dihydropyrimidine dehydrogenase [NADP(+)]
controlled: 1.3.1.2
control type: ACTIVATION

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/ChEBI CHEBI 18191
type: UnificationXref
id: CHEBI:18191
db: ChEBI

Reference/CAS 144-90-1
type: UnificationXref
id: 144-90-1
db: CAS

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108035
pathway component: SubPathwayInteraction108035
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

ChemicalStructure/PW C001189
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ReactionCatalysis100658
type: Catalysis
controller: Beta-ureidopropionase
controlled: 3.5.1.6
control type: ACTIVATION

ReactionCatalysis100657
type: Catalysis
controller: Unknown
controlled: 2.7.1.48
control type: ACTIVATION

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5807
type: UnificationXref
id: 5807
db: ChemSpider

ReactionCatalysis100656
type: Catalysis
controller: Ribonucleoside-diphosphate reductase large subunit
controlled: 1.17.4.1
control type: ACTIVATION

ReactionCatalysis100655
type: Catalysis
controller: Unknown
controlled: 2.1.1.45
control type: ACTIVATION

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

ReactionCatalysis100654
type: Catalysis
controller: Thioredoxin domain-containing protein 3
controlled: 2.7.4.6
control type: ACTIVATION

Reference/ChemSpider 5808
type: UnificationXref
id: 5808
db: ChemSpider

Reference/HMDB HMDB0000296
type: UnificationXref
id: HMDB0000296
db: HMDB

Reference/ChEBI CHEBI 15918
type: UnificationXref
id: CHEBI:15918
db: ChEBI

ReactionCatalysis100653
type: Catalysis
controller: Unknown
controlled: 3.6.1.23
control type: ACTIVATION

Reference/BioCyc TMP
type: UnificationXref
id: TMP
db: BioCyc

Dihydropyrimidine dehydrogenase [NADP(+)]
type: ProteinReference
xref: Reference/UniProt Q8CHR6
organism: Mus musculus

dCMP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCMP

Protein/7725 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Uracil
type: SmallMolecule
cellular location: Cytosol
entity reference: Uracil

ReactionCatalysis100639
type: Catalysis
controller: Unknown
controlled: 2.4.2.4
control type: ACTIVATION

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ReactionCatalysis100641
type: Catalysis
controller: Unknown
controlled: 2.7.1.21
control type: ACTIVATION

ReactionCatalysis100640
type: Catalysis
controller: Unknown
controlled: 3.5.4.12
control type: ACTIVATION

Protein/14178 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydropyrimidine dehydrogenase [NADP(+)]
stoichiometric coefficient: 2.0

ReactionCatalysis100649
type: Catalysis
controller: Unknown
controlled: 2.4.2.4
control type: ACTIVATION

ReactionCatalysis100648
type: Catalysis
controller: Unknown
controlled: 2.7.1.21
control type: ACTIVATION

ReactionCatalysis100647
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

ReactionCatalysis100646
type: Catalysis
controller: Soluble calcium-activated nucleotidase 1
controlled: 3.6.1.6
control type: ACTIVATION

ReactionCatalysis100645
type: Catalysis
controller: Thioredoxin domain-containing protein 3
controlled: 2.7.4.6
control type: ACTIVATION

ReactionCatalysis100644
type: Catalysis
controller: Soluble calcium-activated nucleotidase 1
controlled: 3.6.1.6
control type: ACTIVATION

ReactionCatalysis100643
type: Catalysis
controller: Unknown
controlled: 2.1.1.45
control type: ACTIVATION

ReactionCatalysis100642
type: Catalysis
controller: Unknown
controlled: 2.1.1.45
control type: ACTIVATION

Compound/PW C000790 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCTP
stoichiometric coefficient: 1.0

Reference/CAS 951-78-0
type: UnificationXref
id: 951-78-0
db: CAS

Reference/HMDB HMDB0000079
type: UnificationXref
id: HMDB0000079
db: HMDB

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0003349
type: UnificationXref
id: HMDB0003349
db: HMDB

Reference/HMDB HMDB0000076
type: UnificationXref
id: HMDB0000076
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C000792 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUDP
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

DNA reaction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108032
pathway component: SubPathwayInteraction108032
name: SubPathway

Reference/HMDB HMDB0000089
type: UnificationXref
id: HMDB0000089
db: HMDB

ChemicalStructure/PW C001178
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Reference/ChEBI CHEBI 15901
type: UnificationXref
id: CHEBI:15901
db: ChEBI

Reference/CAS 2149-82-8
type: UnificationXref
id: 2149-82-8
db: CAS

Guanine deaminase
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/ChEBI CHEBI 15842
type: UnificationXref
id: CHEBI:15842
db: ChEBI

Reference/CAS 66-22-8
type: UnificationXref
id: 66-22-8
db: CAS

Compound/PW C001178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-Methylene-THF
stoichiometric coefficient: 1.0

Reference/BioCyc RIBOSE-1P
type: UnificationXref
id: RIBOSE-1P
db: BioCyc

Valine, Leucine, and Isoleucine Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108038
pathway component: SubPathwayInteraction108038
xref: Reference/SMPDB SMP0000032
xref: Reference/PathWhiz PW000051
name: SubPathway

Dihydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrofolic acid

Pentose Phosphate Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108037
pathway component: SubPathwayInteraction108037
xref: Reference/PathWhiz PW000055
xref: Reference/SMPDB SMP0000031
name: SubPathway

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Protein/Generic28 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioredoxin
stoichiometric coefficient: 1.0

Orotic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16742
xref: Reference/HMDB HMDB0000226
xref: Reference/PubChem-compound 967
xref: Reference/BioCyc OROTATE
xref: Reference/KEGG Compound C00295
xref: Reference/CAS 65-86-1
xref: Reference/ChemSpider 942
chemical formula: C5H4N2O4
molecular weight: 156.0171
structure: ChemicalStructure/PW C000151

Compound/PW C000187 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thymidine
stoichiometric coefficient: 1.0

Compound/PW C001087 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 239
type: UnificationXref
id: 239
db: PubChem-compound

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Orotidylic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Orotidylic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ChemicalStructure/PW C000792
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Alanine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108033
pathway component: SubPathwayInteraction108033
xref: Reference/PathWhiz PW000001
xref: Reference/SMPDB SMP0000055
name: SubPathway

ChemicalStructure/PW C000790
type: ChemicalStructure
structure format: SMILES

Compound/PW C000862 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbamoyl phosphate
stoichiometric coefficient: 1.0

Urea Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108036
pathway component: SubPathwayInteraction108036
xref: Reference/SMPDB SMP0000059
xref: Reference/PathWhiz PW000162
name: SubPathway

Cytidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Cytidine

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Reference/PubChem-compound 164628
type: UnificationXref
id: 164628
db: PubChem-compound

Reference/HMDB HMDB0001533
type: UnificationXref
id: HMDB0001533
db: HMDB

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Orotidylic acid
type: SmallMoleculeReference
xref: Reference/CAS 2149-82-8
xref: Reference/BioCyc OROTIDINE-5-PHOSPHATE
xref: Reference/PubChem-compound 160617
xref: Reference/ChemSpider 141140
xref: Reference/ChEBI CHEBI 15842
xref: Reference/HMDB HMDB0000218
xref: Reference/KEGG Compound C01103
chemical formula: C10H13N2O11P
molecular weight: 368.0257
structure: ChemicalStructure/PW C000144

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Compound/PW C001860 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Reference/CAS 2056-98-6
type: UnificationXref
id: 2056-98-6
db: CAS

Reference/ChemSpider 144320
type: UnificationXref
id: 144320
db: ChemSpider

Reference/ChEBI CHEBI 17821
type: UnificationXref
id: CHEBI:17821
db: ChEBI

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

Deoxyribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439287
xref: Reference/KEGG Compound C00672
xref: Reference/CAS 17210-42-3
xref: Reference/BioCyc DEOXY-RIBOSE-1P
xref: Reference/HMDB HMDB0001351
xref: Reference/ChemSpider 388420
xref: Reference/ChEBI CHEBI 28542
chemical formula: C5H11O7P
molecular weight: 214.02425
structure: ChemicalStructure/PW C001042

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

Reference/HMDB HMDB0001546
type: UnificationXref
id: HMDB0001546
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000500 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Thioredoxin disulfide
type: Protein
cellular location: Cytosol
entity reference: Thioredoxin disulfide

Uridine 5'-monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000288
xref: Reference/CAS 58-97-9
xref: Reference/KEGG Compound C00105
xref: Reference/PubChem-compound 6030
xref: Reference/BioCyc UMP
xref: Reference/ChEBI CHEBI 16695
xref: Reference/ChemSpider 5808
chemical formula: C9H13N2O9P
molecular weight: 324.03586
structure: ChemicalStructure/PW C000194

Reference/ChEBI CHEBI 16742
type: UnificationXref
id: CHEBI:16742
db: ChEBI

Reference/ChemSpider 9319
type: UnificationXref
id: 9319
db: ChemSpider

Reference/CAS 50-89-5
type: UnificationXref
id: 50-89-5
db: CAS

Reference/HMDB HMDB0000218
type: UnificationXref
id: HMDB0000218
db: HMDB

Reference/BioCyc URIDINE
type: UnificationXref
id: URIDINE
db: BioCyc

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000226
type: UnificationXref
id: HMDB0000226
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

ChemicalStructure/PW C000144
type: ChemicalStructure
structure format: SMILES

SubPathwayInteraction108036
type: Interaction
name: SubPathway108036Reaction
name: SubPathwayReaction
participant: Carbamoyl phosphate

Reference/BioCyc CDP
type: UnificationXref
id: CDP
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

SubPathwayInteraction108037
type: Interaction
name: SubPathwayReaction
name: SubPathway108037Reaction
participant: Phosphoribosyl pyrophosphate

Reference/CAS 107-95-9
type: UnificationXref
id: 107-95-9
db: CAS

SubPathwayInteraction108038
type: Interaction
name: SubPathwayReaction
name: SubPathway108038Reaction
participant: 3-Aminoisobutanoic acid

Reference/ChemSpider 84022
type: UnificationXref
id: 84022
db: ChemSpider

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

SubPathwayInteraction108032
type: Interaction
name: SubPathway108032Reaction
name: SubPathwayReaction
participant: Cytidine triphosphate
participant: Uridine 5'-diphosphate
participant: Uridine triphosphate
participant: CDP

SubPathwayInteraction108033
type: Interaction
name: SubPathwayReaction
name: SubPathway108033Reaction
participant: β-Alanine

SubPathwayInteraction108034
type: Interaction
name: SubPathwayReaction
name: SubPathway108034Reaction
participant: Thymidine 5'-triphosphate
participant: dCTP

SubPathwayInteraction108035
type: Interaction
name: SubPathway108035Reaction
name: SubPathwayReaction
participant: L-Glutamine

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/BioCyc TDP
type: UnificationXref
id: TDP
db: BioCyc

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Thymine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17821
xref: Reference/ChemSpider 1103
xref: Reference/CAS 65-71-4
xref: Reference/PubChem-compound 1135
xref: Reference/HMDB HMDB0000262
xref: Reference/BioCyc THYMINE
xref: Reference/KEGG Compound C00178
chemical formula: C5H6N2O2
molecular weight: 126.04293
structure: ChemicalStructure/PW C000179

Thymine
type: SmallMolecule
cellular location: Cytosol
entity reference: Thymine

Reference/ChEBI CHEBI 16704
type: UnificationXref
id: CHEBI:16704
db: ChEBI

Reference/ChEBI CHEBI 15859
type: UnificationXref
id: CHEBI:15859
db: ChEBI

Reference/BioCyc DCMP
type: UnificationXref
id: DCMP
db: BioCyc

Reference/ChEBI CHEBI 15633
type: UnificationXref
id: CHEBI:15633
db: ChEBI

Reference/ChEBI CHEBI 15636
type: UnificationXref
id: CHEBI:15636
db: ChEBI

Compound/PW C000937 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCMP
stoichiometric coefficient: 1.0

Reference/ChemSpider 109
type: UnificationXref
id: 109
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/ChEBI CHEBI 28931
type: UnificationXref
id: CHEBI:28931
db: ChEBI

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Thymidine 5'-triphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00459
xref: Reference/CAS 365-08-2
xref: Reference/ChEBI CHEBI 18077
xref: Reference/ChemSpider 58493
xref: Reference/PubChem-compound 64968
xref: Reference/HMDB HMDB0001342
xref: Reference/BioCyc TTP
chemical formula: C10H17N2O14P3
molecular weight: 481.98926
structure: ChemicalStructure/PW C001035

Reference/ChEBI CHEBI 16958
type: UnificationXref
id: CHEBI:16958
db: ChEBI

Thymidine
type: SmallMoleculeReference
xref: Reference/BioCyc THYMIDINE
xref: Reference/ChEBI CHEBI 17748
xref: Reference/CAS 50-89-5
xref: Reference/PubChem-compound 5789
xref: Reference/ChemSpider 5585
xref: Reference/HMDB HMDB0000273
xref: Reference/KEGG Compound C00214
chemical formula: C10H14N2O5
molecular weight: 242.09027
structure: ChemicalStructure/PW C000187

Beta-ureidopropionase
type: ProteinReference
xref: Reference/UniProt Q8VC97
organism: Mus musculus

Reference/ChEBI CHEBI 17622
type: UnificationXref
id: CHEBI:17622
db: ChEBI

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: Reference/UniProt Q9EQF6
organism: Mus musculus

Reference/ChEBI CHEBI 17625
type: UnificationXref
id: CHEBI:17625
db: ChEBI

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000962
type: ChemicalStructure
structure format: SMILES

dUMP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17622
xref: Reference/ChemSpider 58574
xref: Reference/HMDB HMDB0001409
xref: Reference/CAS 964-26-1
xref: Reference/BioCyc DUMP
xref: Reference/PubChem-compound 65063
xref: Reference/KEGG Compound C00365
chemical formula: C9H13N2O8P
molecular weight: 308.04095
structure: ChemicalStructure/PW C001087

Reference/PubChem-compound 150855
type: UnificationXref
id: 150855
db: PubChem-compound

Reference/BioCyc DCTP
type: UnificationXref
id: DCTP
db: BioCyc

3'-AMP
type: SmallMolecule
cellular location: Cytosol
entity reference: 3'-AMP

Reference/ChEBI CHEBI 16300
type: UnificationXref
id: CHEBI:16300
db: ChEBI

Reference/ChEBI CHEBI 15698
type: UnificationXref
id: CHEBI:15698
db: ChEBI

Reference/BioCyc CARBAMOYL-P
type: UnificationXref
id: CARBAMOYL-P
db: BioCyc

quinol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17594

thioredoxin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15033

thioredoxin disulfide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18191

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Beta-ureidopropionase
type: Protein
cellular location: Cytosol
entity reference: Beta-ureidopropionase

Reference/CAS 84-21-9
type: UnificationXref
id: 84-21-9
db: CAS

Reference/CAS 14075-00-4
type: UnificationXref
id: 14075-00-4
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5585
type: UnificationXref
id: 5585
db: ChemSpider

Reference/HMDB HMDB0000828
type: UnificationXref
id: HMDB0000828
db: HMDB

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000950
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Reference/PubChem-compound 439216
type: UnificationXref
id: 439216
db: PubChem-compound

Compound/Generic53 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: thioredoxin disulfide
stoichiometric coefficient: 1.0

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Unknown
type: ProteinReference
organism: Mus musculus

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Reference/KEGG Compound C00620
type: UnificationXref
id: C00620
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/PubChem-compound 160663
type: UnificationXref
id: 160663
db: PubChem-compound

Compound/PW C000204 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uracil
stoichiometric coefficient: 1.0

Reference/CAS 1173-82-6
type: UnificationXref
id: 1173-82-6
db: CAS

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Protein/13677 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Dihydropyrimidinase-related protein 5
stoichiometric coefficient: 4.0

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/PubChem-compound 439236
type: UnificationXref
id: 439236
db: PubChem-compound

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Reference/PubChem-compound 278
type: UnificationXref
id: 278
db: PubChem-compound

Thymidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Thymidine

Reference/KEGG Compound C00881
type: UnificationXref
id: C00881
db: KEGG Compound

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/ChEBI CHEBI 17672
type: UnificationXref
id: CHEBI:17672
db: ChEBI

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/ChEBI CHEBI 27468
type: UnificationXref
id: CHEBI:27468
db: ChEBI

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/CAS 491-97-4
type: UnificationXref
id: 491-97-4
db: CAS

Reference/ChEBI CHEBI 16311
type: UnificationXref
id: CHEBI:16311
db: ChEBI

Reference/KEGG Compound C00415
type: UnificationXref
id: C00415
db: KEGG Compound

Reference/ChemSpider 58601
type: UnificationXref
id: 58601
db: ChemSpider

Cytidine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Cytidine triphosphate
name: SubPathwayInput

ChemicalStructure/PW C000987
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/CAS 17210-42-3
type: UnificationXref
id: 17210-42-3
db: CAS

Compound/PW C000987 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dTDP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28542
type: UnificationXref
id: CHEBI:28542
db: ChEBI

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Reference/CAS 65-71-4
type: UnificationXref
id: 65-71-4
db: CAS

Reference/KEGG Compound C00429
type: UnificationXref
id: C00429
db: KEGG Compound

Deoxycytidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxycytidine

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

ChemicalStructure/PW C001852
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CC(=O)NC(=O)N1

quinol
type: SmallMolecule
cellular location: Cytosol
entity reference: quinol

Reference/UniProt Q715T0
type: UnificationXref
id: Q715T0
db: UniProt

Reference/ChEBI CHEBI 1670
type: UnificationXref
id: CHEBI:1670
db: ChEBI

Reference/HMDB HMDB0003911
type: UnificationXref
id: HMDB0003911
db: HMDB