Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/KEGG Compound C00314
type: UnificationXref
id: C00314
db: KEGG Compound

Compound/PW C001017 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine 5'-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

3.1.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Pyridoxal
right: Phosphoric acid
spontaneous: false
EC number: 3.1.3.1
left: Pyridoxal 5'-phosphate
left: Water
name: Pyridoxal 5'-phosphate + Water ← Phosphoric acid + Pyridoxal
conversion direction: RIGHT_TO_LEFT

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Sphingolipid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108019
pathway component: SubPathwayInteraction108019
xref: Reference/PathWhiz PW000148
xref: Reference/SMPDB SMP0000034
name: SubPathway

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Valine, Leucine, and Isoleucine Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108022
pathway component: SubPathwayInteraction108022
xref: Reference/SMPDB SMP0000032
xref: Reference/PathWhiz PW000051
name: SubPathway

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/ChEBI CHEBI 28803
type: UnificationXref
id: CHEBI:28803
db: ChEBI

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Reaction1015
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003016 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003017 Cytosol/Stoichiometry/1.0
right: 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
spontaneous: false
left: 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
name: 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate → 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
conversion direction: LEFT_TO_RIGHT

Reaction1016
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001850 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000161 Cytosol/Stoichiometry/1.0
right: Pyridoxine
spontaneous: false
left: Glycolaldehyde
name: Glycolaldehyde → Pyridoxine
conversion direction: LEFT_TO_RIGHT

Compound/PW C003017 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
stoichiometric coefficient: 1.0

Reaction1014
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000011 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003016 Cytosol/Stoichiometry/1.0
right: 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
spontaneous: false
left: 4-Pyridoxic acid
name: 4-Pyridoxic acid → 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis99818
type: Catalysis
controller: Pyridoxal kinase
controlled: 3.1.3.1
control type: ACTIVATION

ReactionCatalysis99819
type: Catalysis
controller: Unknown
controlled: 1.4.3.5
control type: ACTIVATION

ReactionCatalysis99817
type: Catalysis
controller: Unknown
controlled: 3.1.3.1
control type: ACTIVATION

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
type: UnificationXref
id: DIHYDROXYPHENYLGLYCOLALDEHYDE
db: BioCyc

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Pyridoxal phosphate phosphatase
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/PathWhiz PW000051
type: UnificationXref
id: PW000051
db: PathWhiz

Pyridoxamine 5'-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyridoxamine 5'-phosphate

Reference/CAS 66-72-8
type: UnificationXref
id: 66-72-8
db: CAS

Pyridoxamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyridoxamine

Pyridoxine
type: SmallMoleculeReference
xref: Reference/CAS 65-23-6
xref: Reference/ChemSpider 1025
xref: Reference/KEGG Compound C00314
xref: Reference/BioCyc CPD-455
xref: Reference/HMDB HMDB0000239
xref: Reference/ChEBI CHEBI 16709
xref: Reference/PubChem-compound 1054
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000161

Reference/ChemSpider 1026
type: UnificationXref
id: 1026
db: ChemSpider

Reference/ChemSpider 1025
type: UnificationXref
id: 1025
db: ChemSpider

Reference/ChemSpider 1024
type: UnificationXref
id: 1024
db: ChemSpider

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

ReactionCatalysis99829
type: Catalysis
controller: Pyridoxal phosphate phosphatase
controlled: Reaction109609
control type: ACTIVATION

ReactionCatalysis99827
type: Catalysis
controller: Unknown
controlled: 3.1.3.1
control type: ACTIVATION

ReactionCatalysis99828
type: Catalysis
controller: Pyridoxal phosphate phosphatase
controlled: Reaction109608
control type: ACTIVATION

ReactionCatalysis99825
type: Catalysis
controller: Unknown
controlled: 1.4.3.5
control type: ACTIVATION

ReactionCatalysis99826
type: Catalysis
controller: Pyridoxal phosphate phosphatase
controlled: 3.1.3.1
control type: ACTIVATION

ReactionCatalysis99823
type: Catalysis
controller: Pyridoxal kinase
controlled: 2.7.1.35
control type: ACTIVATION

Reference/PubChem-compound 6723
type: UnificationXref
id: 6723
db: PubChem-compound

ReactionCatalysis99824
type: Catalysis
controller: Unknown
controlled: 1.4.3.5
control type: ACTIVATION

Reference/ChemSpider 1023
type: UnificationXref
id: 1023
db: ChemSpider

ReactionCatalysis99821
type: Catalysis
controller: Unknown
controlled: 1.4.3.5
control type: ACTIVATION

Reference/PathWhiz PW000042
type: UnificationXref
id: PW000042
db: PathWhiz

Reference/ChemSpider 1022
type: UnificationXref
id: 1022
db: ChemSpider

ReactionCatalysis99822
type: Catalysis
controller: Pyridoxal kinase
controlled: 2.7.1.35
control type: ACTIVATION

Reference/PathWhiz PW121824
type: UnificationXref
id: PW121824
db: PathWhiz

Reference/ChemSpider 1021
type: UnificationXref
id: 1021
db: ChemSpider

ReactionCatalysis99820
type: Catalysis
controller: Unknown
controlled: Reaction109601
control type: ACTIVATION

Compound/PW C001850 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycolaldehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/BioCyc PYRIDOXAL PHOSPHATE
type: UnificationXref
id: PYRIDOXAL_PHOSPHATE
db: BioCyc

4-Pyridoxic acid
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-1112
xref: Reference/HMDB HMDB0000017
xref: Reference/KEGG Compound C00847
xref: Reference/ChEBI CHEBI 17405
xref: Reference/ChemSpider 6467
xref: Reference/PubChem-compound 6723
xref: Reference/CAS 82-82-6
chemical formula: C8H9NO4
molecular weight: 183.05316
structure: ChemicalStructure/PW C000011

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Reference/PathWhiz PW000158
type: UnificationXref
id: PW000158
db: PathWhiz

Reference/PathWhiz PW000157
type: UnificationXref
id: PW000157
db: PathWhiz

Pyridoxamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001431
xref: Reference/ChEBI CHEBI 16410
xref: Reference/KEGG Compound C00534
xref: Reference/PubChem-compound 1052
xref: Reference/CAS 85-87-0
xref: Reference/ChemSpider 1023
xref: Reference/BioCyc PYRIDOXAMINE
chemical formula: C8H12N2O2
molecular weight: 168.08987
structure: ChemicalStructure/PW C001106

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/PathWhiz PW000152
type: UnificationXref
id: PW000152
db: PathWhiz

Compound/PW C000161 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine
stoichiometric coefficient: 1.0

Reference/CAS 529-96-4
type: UnificationXref
id: 529-96-4
db: CAS

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Reference/BioCyc CPD-455
type: UnificationXref
id: CPD-455
db: BioCyc

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

4-Pyridoxic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Pyridoxic acid

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C003016 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
stoichiometric coefficient: 1.0

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

ChemicalStructure/PW C000011
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CO)C(C(O)=O)=C1O

Reference/BioCyc PYRIDOXAMINE-5P
type: UnificationXref
id: PYRIDOXAMINE-5P
db: BioCyc

Reference/HMDB HMDB0001545
type: UnificationXref
id: HMDB0001545
db: HMDB

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C04604
type: UnificationXref
id: C04604
db: KEGG Compound

Pyridoxine 5'-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyridoxine 5'-phosphate

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

ChemicalStructure/PW C001106
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(O)C(CN)=C(CO)C=N1

Reference/CAS 141-46-8
type: UnificationXref
id: 141-46-8
db: CAS

Glycolaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycolaldehyde

Reference/HMDB HMDB0001431
type: UnificationXref
id: HMDB0001431
db: HMDB

Pyridoxine
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyridoxine

Reference/HMDB HMDB0001555
type: UnificationXref
id: HMDB0001555
db: HMDB

Reference/KEGG Compound C00250
type: UnificationXref
id: C00250
db: KEGG Compound

Glycolaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17071
xref: Reference/PubChem-compound 756
xref: Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
xref: Reference/ChemSpider 736
xref: Reference/HMDB HMDB0003344
xref: Reference/CAS 141-46-8
xref: Reference/KEGG Compound C00266
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C001850

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Phenylalanine and Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108021
pathway component: SubPathwayInteraction108021
xref: Reference/SMPDB SMP0000008
xref: Reference/PathWhiz PW000042
name: SubPathway

Gluconeogenesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108016
pathway component: SubPathwayInteraction108016
xref: Reference/SMPDB SMP0000128
xref: Reference/PathWhiz PW000152
name: SubPathway

Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108017
pathway component: SubPathwayInteraction108017
xref: Reference/PathWhiz PW000142
xref: Reference/SMPDB SMP0000006
name: SubPathway

Glycine and Serine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108020
pathway component: SubPathwayInteraction108020
xref: Reference/PathWhiz PW000157
xref: Reference/SMPDB SMP0000004
name: SubPathway

Reference/KEGG Compound C00018
type: UnificationXref
id: C00018
db: KEGG Compound

Reference/ChEBI CHEBI 18335
type: UnificationXref
id: CHEBI:18335
db: ChEBI

Reference/HMDB HMDB0001319
type: UnificationXref
id: HMDB0001319
db: HMDB

Pyridoxine 5'-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 1026
xref: Reference/KEGG Compound C00627
xref: Reference/ChEBI CHEBI 28803
xref: Reference/HMDB HMDB0001319
xref: Reference/BioCyc PYRIDOXINE-5P
xref: Reference/PubChem-compound 1055
xref: Reference/CAS 447-05-2
chemical formula: C8H12NO6P
molecular weight: 249.04022
structure: ChemicalStructure/PW C001017

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/PubChem-compound 440403
type: UnificationXref
id: 440403
db: PubChem-compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Compound/PW C001188 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/SMPDB SMP0120568
type: UnificationXref
id: SMP0120568
db: SMPDB

Reference/HMDB HMDB0000239
type: UnificationXref
id: HMDB0000239
db: HMDB

Reference/ChEBI CHEBI 16709
type: UnificationXref
id: CHEBI:16709
db: ChEBI

Pyridoxal kinase
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Pyridoxal 5'-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00018
xref: Reference/PubChem-compound 1051
xref: Reference/BioCyc PYRIDOXAL PHOSPHATE
xref: Reference/CAS 54-47-7
xref: Reference/ChEBI CHEBI 18405
xref: Reference/HMDB HMDB0001491
xref: Reference/ChemSpider 1022
chemical formula: C8H10NO6P
molecular weight: 247.02457
structure: ChemicalStructure/PW C001148

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Pyridoxal
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Pyridoxal

Reference/BioCyc PYRIDOXAL
type: UnificationXref
id: PYRIDOXAL
db: BioCyc

Reference/KEGG Compound C00266
type: UnificationXref
id: C00266
db: KEGG Compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Reference/CAS 54-47-7
type: UnificationXref
id: 54-47-7
db: CAS

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C001148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PYRIDOXAMINE
type: UnificationXref
id: PYRIDOXAMINE
db: BioCyc

Porphyrin Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108018
pathway component: SubPathwayInteraction108018
xref: Reference/PathWhiz PW000158
xref: Reference/SMPDB SMP0000024
name: SubPathway

Reference/ChEBI CHEBI 16410
type: UnificationXref
id: CHEBI:16410
db: ChEBI

Reference/SMPDB SMP0000128
type: UnificationXref
id: SMP0000128
db: SMPDB

Reference/SMPDB SMP0000008
type: UnificationXref
id: SMP0000008
db: SMPDB

Hypophosphatasia
type: Pathway
pathway order: PathwayEnzymeReaction/2111411
pathway order: PathwayEnzymeReaction/2111399
pathway order: PathwayEnzymeReaction/2111410
pathway order: PathwayEnzymeReaction/2111413
pathway order: PathwaySubPathway/108019
pathway order: PathwayEnzymeReaction/2111412
pathway order: PathwayEnzymeReaction/2111414
pathway order: PathwayTransport/2111416
pathway order: PathwayTransport/2111415
pathway order: PathwaySubPathway/108016
pathway order: PathwaySubPathway/108017
pathway order: PathwaySubPathway/108018
pathway order: PathwayEnzymeReaction/2111409
pathway order: PathwaySubPathway/108022
pathway order: PathwayEnzymeReaction/2111400
pathway order: PathwaySubPathway/108020
pathway order: PathwaySubPathway/108021
pathway order: PathwayEnzymeReaction/2111402
pathway order: PathwayEnzymeReaction/2111401
pathway order: PathwayEnzymeReaction/2111404
pathway order: PathwayEnzymeReaction/2111403
pathway order: PathwayEnzymeReaction/2111406
pathway order: PathwayEnzymeReaction/2111405
pathway order: PathwayEnzymeReaction/2111408
pathway order: PathwayEnzymeReaction/2111407
pathway component: ReactionCatalysis99829
pathway component: Transport1131
pathway component: Transport1130
pathway component: ReactionCatalysis99827
pathway component: ReactionCatalysis99828
pathway component: ReactionCatalysis99825
pathway component: ReactionCatalysis99826
pathway component: 3.1.3.1
pathway component: ReactionCatalysis99823
pathway component: ReactionCatalysis99824
pathway component: ReactionCatalysis99821
pathway component: ReactionCatalysis99822
pathway component: ReactionCatalysis99820
pathway component: Sphingolipid Metabolism
pathway component: Valine, Leucine, and Isoleucine Degradation
pathway component: Reaction1015
pathway component: Reaction1016
pathway component: Reaction1014
pathway component: 1.4.3.5
pathway component: Reaction109608
pathway component: ReactionCatalysis99818
pathway component: Reaction109609
pathway component: ReactionCatalysis99819
pathway component: ReactionCatalysis99817
pathway component: Reaction109601
pathway component: 2.7.1.35
pathway component: Phenylalanine and Tyrosine Metabolism
pathway component: Gluconeogenesis
pathway component: Tyrosine Metabolism
pathway component: Glycine and Serine Metabolism
pathway component: Porphyrin Metabolism
xref: Reference/SMPDB SMP0120568
xref: Reference/PathWhiz PW121824
organism: Mus musculus

3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate

Reference/SMPDB SMP0000006
type: UnificationXref
id: SMP0000006
db: SMPDB

ChemicalStructure/PW C001017
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(CO)=C1O

ChemicalStructure/PW C001148
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O

Reference/HMDB HMDB0000017
type: UnificationXref
id: HMDB0000017
db: HMDB

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/SMPDB SMP0000004
type: UnificationXref
id: SMP0000004
db: SMPDB

Reference/ChemSpider 389728
type: UnificationXref
id: 389728
db: ChemSpider

Reference/KEGG Compound C00847
type: UnificationXref
id: C00847
db: KEGG Compound

Reference/PubChem-compound 756
type: UnificationXref
id: 756
db: PubChem-compound

Reference/PubChem-compound 440898
type: UnificationXref
id: 440898
db: PubChem-compound

Reference/CAS 65-23-6
type: UnificationXref
id: 65-23-6
db: CAS

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/ChEBI CHEBI 17071
type: UnificationXref
id: CHEBI:17071
db: ChEBI

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

SubPathwayInteraction108018
type: Interaction
name: SubPathway108018Reaction
name: SubPathwayReaction
participant: Pyridoxal 5'-phosphate

SubPathwayInteraction108019
type: Interaction
name: SubPathwayReaction
name: SubPathway108019Reaction
participant: Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyridoxal 5'-phosphate
name: SubPathwayInput

Reference/CAS 85-87-0
type: UnificationXref
id: 85-87-0
db: CAS

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 82-82-6
type: UnificationXref
id: 82-82-6
db: CAS

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

SubPathwayInteraction108020
type: Interaction
name: SubPathway108020Reaction
name: SubPathwayReaction
participant: Pyridoxal 5'-phosphate

Pyridoxal
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1050
xref: Reference/CAS 66-72-8
xref: Reference/KEGG Compound C00250
xref: Reference/HMDB HMDB0001545
xref: Reference/ChEBI CHEBI 17310
xref: Reference/ChemSpider 1021
xref: Reference/BioCyc PYRIDOXAL
chemical formula: C8H9NO3
molecular weight: 167.05824
structure: ChemicalStructure/PW C001188

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Pyridoxamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Pyridoxamine

Compound/PW C001106 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxamine
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000024
type: UnificationXref
id: SMP0000024
db: SMPDB

SubPathwayInteraction108021
type: Interaction
name: SubPathway108021Reaction
name: SubPathwayReaction
participant: Pyridoxal 5'-phosphate

SubPathwayInteraction108022
type: Interaction
name: SubPathway108022Reaction
name: SubPathwayReaction
participant: Pyridoxal 5'-phosphate

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/ChEBI CHEBI 17978
type: UnificationXref
id: CHEBI:17978
db: ChEBI

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

Reference/KEGG Compound C00627
type: UnificationXref
id: C00627
db: KEGG Compound

Unknown
type: ProteinReference
organism: Mus musculus

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Pyridoxamine 5'-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00647
xref: Reference/BioCyc PYRIDOXAMINE-5P
xref: Reference/HMDB HMDB0001555
xref: Reference/ChEBI CHEBI 18335
xref: Reference/ChemSpider 1024
xref: Reference/CAS 529-96-4
xref: Reference/PubChem-compound 1053
chemical formula: C8H13N2O5P
molecular weight: 248.05621
structure: ChemicalStructure/PW C001197

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17978
xref: Reference/KEGG Compound C04604
xref: Reference/HMDB HMDB0006955
xref: Reference/PubChem-compound 440403
xref: Reference/ChemSpider 389354
chemical formula: C8H7NO5
molecular weight: 197.03242
structure: ChemicalStructure/PW C003017

2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006954
xref: Reference/KEGG Compound C06050
xref: Reference/ChemSpider 389728
xref: Reference/PubChem-compound 440898
chemical formula: C8H7NO4
molecular weight: 181.0375
structure: ChemicalStructure/PW C003016

Reference/KEGG Compound C06050
type: UnificationXref
id: C06050
db: KEGG Compound

SubPathwayInteraction108016
type: Interaction
name: SubPathway108016Reaction
name: SubPathwayReaction
participant: Pyridoxal 5'-phosphate

Reference/SMPDB SMP0000034
type: UnificationXref
id: SMP0000034
db: SMPDB

Reference/HMDB HMDB0001491
type: UnificationXref
id: HMDB0001491
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

SubPathwayInteraction108017
type: Interaction
name: SubPathwayReaction
name: SubPathway108017Reaction
participant: Pyridoxal 5'-phosphate

ChemicalStructure/PW C000161
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(O)C(CO)=C(CO)C=N1

Reference/SMPDB SMP0000032
type: UnificationXref
id: SMP0000032
db: SMPDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PubChem-compound 1050
type: UnificationXref
id: 1050
db: PubChem-compound

Reference/PubChem-compound 1051
type: UnificationXref
id: 1051
db: PubChem-compound

Reference/BioCyc CPD-1112
type: UnificationXref
id: CPD-1112
db: BioCyc

Reference/PubChem-compound 1052
type: UnificationXref
id: 1052
db: PubChem-compound

Reference/PathWhiz PW000142
type: UnificationXref
id: PW000142
db: PathWhiz

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Transport1131
type: Transport
participant stoichiometry: Compound/PW C001106 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106 Extracellular Space/Stoichiometry/1.0
right: Pyridoxamine
spontaneous: false
left: Pyridoxamine
name: Pyridoxamine (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C001188 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal
stoichiometric coefficient: 1.0

Transport1130
type: Transport
participant stoichiometry: Compound/PW C001188 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Extracellular Space/Stoichiometry/1.0
right: Pyridoxal
spontaneous: false
left: Pyridoxal
name: Pyridoxal (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW000148
type: UnificationXref
id: PW000148
db: PathWhiz

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Reference/ChemSpider 736
type: UnificationXref
id: 736
db: ChemSpider

Reference/PubChem-compound 1053
type: UnificationXref
id: 1053
db: PubChem-compound

Reference/PubChem-compound 1054
type: UnificationXref
id: 1054
db: PubChem-compound

Reference/PubChem-compound 1055
type: UnificationXref
id: 1055
db: PubChem-compound

ChemicalStructure/PW C001188
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CO)C(C=O)=C1O

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/HMDB HMDB0006954
type: UnificationXref
id: HMDB0006954
db: HMDB

Reference/HMDB HMDB0006955
type: UnificationXref
id: HMDB0006955
db: HMDB

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00647
type: UnificationXref
id: C00647
db: KEGG Compound

1.4.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001197 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Pyridoxal 5'-phosphate
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.5
left: Oxygen
left: Pyridoxamine 5'-phosphate
left: Water
name: Oxygen + Pyridoxamine 5'-phosphate + Water → Ammonia + Hydrogen peroxide + Pyridoxal 5'-phosphate
conversion direction: LEFT_TO_RIGHT

1.4.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001017 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
right: Pyridoxal 5'-phosphate
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.5
left: Oxygen
left: Pyridoxine 5'-phosphate
name: Oxygen + Pyridoxine 5'-phosphate ← Hydrogen peroxide + Pyridoxal 5'-phosphate
conversion direction: RIGHT_TO_LEFT

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

3.1.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001197 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Pyridoxamine 5'-phosphate
right: Water
spontaneous: false
EC number: 3.1.3.1
left: Phosphoric acid
left: Pyridoxamine
name: Phosphoric acid + Pyridoxamine ← Pyridoxamine 5'-phosphate + Water
conversion direction: RIGHT_TO_LEFT

Reaction109608
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Pyridoxal
right: Phosphoric acid
spontaneous: false
left: Pyridoxal 5'-phosphate
left: Water
name: Pyridoxal 5'-phosphate + Water → Phosphoric acid + Pyridoxal
conversion direction: LEFT_TO_RIGHT

Reaction109609
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001017 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000161 Cytosol/Stoichiometry/1.0
right: Pyridoxine
right: Phosphoric acid
spontaneous: false
left: Pyridoxine 5'-phosphate
left: Water
name: Pyridoxine 5'-phosphate + Water → Phosphoric acid + Pyridoxine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18405
type: UnificationXref
id: CHEBI:18405
db: ChEBI

Protein/7725 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Compound/PW C001197 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxamine 5'-phosphate
stoichiometric coefficient: 1.0

1.4.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Pyridoxal
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.5
left: Oxygen
left: Pyridoxamine
left: Water
name: Oxygen + Pyridoxamine + Water → Ammonia + Hydrogen peroxide + Pyridoxal
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17310
type: UnificationXref
id: CHEBI:17310
db: ChEBI

Reaction109601
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000011 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: 4-Pyridoxic acid
right: Hydrogen peroxide
spontaneous: false
left: Oxygen
left: Pyridoxal
left: Water
name: Oxygen + Pyridoxal + Water → 4-Pyridoxic acid + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

1.4.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000161 Cytosol/Stoichiometry/1.0
right: Pyridoxal
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.5
left: Oxygen
left: Pyridoxine
name: Oxygen + Pyridoxine ← Hydrogen peroxide + Pyridoxal
conversion direction: RIGHT_TO_LEFT

2.7.1.35
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001017 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000161 Cytosol/Stoichiometry/1.0
right: Pyridoxine 5'-phosphate
right: Water
spontaneous: false
EC number: 2.7.1.35
left: Pyridoxine
left: Phosphoric acid
name: Phosphoric acid + Pyridoxine → Pyridoxine 5'-phosphate + Water
conversion direction: LEFT_TO_RIGHT

2.7.1.35
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001197 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Pyridoxamine 5'-phosphate
right: Water
spontaneous: false
EC number: 2.7.1.35
left: Phosphoric acid
left: Pyridoxamine
name: Phosphoric acid + Pyridoxamine → Pyridoxamine 5'-phosphate + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C000011 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Pyridoxic acid
stoichiometric coefficient: 1.0

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

ChemicalStructure/PW C003016
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(C=O)C(C(O)=O)=C1O

ChemicalStructure/PW C003017
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(C(O)=O)C(C(O)=O)=C1O

ChemicalStructure/PW C001197
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(CN)=C1O

Reference/CAS 447-05-2
type: UnificationXref
id: 447-05-2
db: CAS

Reference/KEGG Compound C00534
type: UnificationXref
id: C00534
db: KEGG Compound

Reference/ChEBI CHEBI 17405
type: UnificationXref
id: CHEBI:17405
db: ChEBI

Reference/BioCyc PYRIDOXINE-5P
type: UnificationXref
id: PYRIDOXINE-5P
db: BioCyc

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001106 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxamine
stoichiometric coefficient: 1.0

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate

Reference/HMDB HMDB0003344
type: UnificationXref
id: HMDB0003344
db: HMDB

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/ChemSpider 6467
type: UnificationXref
id: 6467
db: ChemSpider

Reference/ChemSpider 389354
type: UnificationXref
id: 389354
db: ChemSpider

Pyridoxal
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyridoxal

ChemicalStructure/PW C001850
type: ChemicalStructure
structure format: SMILES
structure data: OCC=O

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB