Glutamine--fructose-6-phosphate aminotransferase
type: Complex
component stoichiometry: Protein/13644 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 388356
type: UnificationXref
id: 388356
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

ReactionCatalysis99928
type: Catalysis
controller: Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N-acetylmannosamine kinase
controlled: Reaction109668
control type: ACTIVATION

ReactionCatalysis99929
type: Catalysis
controller: Hexokinase-1
controlled: 2.7.1.1
control type: ACTIVATION

ReactionCatalysis99926
type: Catalysis
controller: Chitotriosidase-1
controlled: 3.2.1.14
control type: ACTIVATION

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

ReactionCatalysis99927
type: Catalysis
controller: Phosphoacetylglucosamine mutase
controlled: 5.4.2.3
control type: ACTIVATION

ReactionCatalysis98717
type: Catalysis
controller: N-acetylneuraminate lyase
controlled: 4.1.3.3
control type: ACTIVATION

ReactionCatalysis99925
type: Catalysis
controller: Chitotriosidase-1
controlled: 3.2.1.14
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Protein/13644 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
stoichiometric coefficient: 4.0

ReactionCatalysis98712
type: Catalysis
controller: N-acylglucosamine 2-epimerase
controlled: 5.1.3.8
control type: ACTIVATION

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Cytidine triphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Cytidine triphosphate

ReactionCatalysis98711
type: Catalysis
controller: UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
controlled: Reaction108554
control type: ACTIVATION

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/ChemSpider 388352
type: UnificationXref
id: 388352
db: ChemSpider

Reference/UniProt Q99KK2
type: UnificationXref
id: Q99KK2
db: UniProt

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/ChemSpider 9271300
type: UnificationXref
id: 9271300
db: ChemSpider

Reference/HMDB HMDB0003362
type: UnificationXref
id: HMDB0003362
db: HMDB

Reference/HMDB HMDB0001062
type: UnificationXref
id: HMDB0001062
db: HMDB

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/ChEBI CHEBI 62165
type: UnificationXref
id: CHEBI:62165
db: ChEBI

N-acylneuraminate cytidylyltransferase
type: Complex
component stoichiometry: Protein/13649 Nucleus/Stoichiometry/4.0
cellular location: Nucleus
component: N-acylneuraminate cytidylyltransferase

Reference/KEGG Compound C00329
type: UnificationXref
id: C00329
db: KEGG Compound

Compound/PW C000969 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis99933
type: Catalysis
controller: Sialic acid synthase
controlled: Reaction109673
control type: ACTIVATION

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PathWhiz PW121855
type: UnificationXref
id: PW121855
db: PathWhiz

Reference/ChEBI CHEBI 16264
type: UnificationXref
id: CHEBI:16264
db: ChEBI

ReactionCatalysis99931
type: Catalysis
controller: Sialic acid synthase
controlled: Reaction109671
control type: ACTIVATION

ReactionCatalysis98721
type: Catalysis
controller: N-acylneuraminate cytidylyltransferase
controlled: 2.7.7.43
control type: ACTIVATION

ReactionCatalysis99932
type: Catalysis
controller: Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N-acetylmannosamine kinase
controlled: Reaction109672
control type: ACTIVATION

Reference/CAS 53188-23-1
type: UnificationXref
id: 53188-23-1
db: CAS

Chitobiose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003556
xref: Reference/ChemSpider 17216232
xref: Reference/CAS 577-76-4
xref: Reference/PubChem-compound 22833609
xref: Reference/KEGG Compound C01674
xref: Reference/BioCyc CHITOBIOSE
chemical formula: C15H26N2O12
molecular weight: 426.14856
structure: ChemicalStructure/PW C001925

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15784
xref: Reference/ChemSpider 389821
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
xref: Reference/HMDB HMDB0001062
xref: Reference/KEGG Compound C00357
xref: Reference/CAS 102029-88-9
xref: Reference/PubChem-compound 440996
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C000837

ReactionCatalysis99930
type: Catalysis
controller: Hexokinase-1
controlled: 2.7.1.1
control type: ACTIVATION

ReactionCatalysis98720
type: Catalysis
controller: N-acylneuraminate-9-phosphatase
controlled: 3.1.3.29
control type: ACTIVATION

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
type: Protein
cellular location: Cytoplasm
entity reference: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

TransportCatalysis924
type: Catalysis
controller: Solute carrier family 17 member 9
controlled: Transport1041
control type: ACTIVATION

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000155 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylneuraminic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C000196 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

Reference/ChemSpider 17216232
type: UnificationXref
id: 17216232
db: ChemSpider

Pyrophosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Pyrophosphate

Cytidine monophosphate N-acetylneuraminic acid
type: SmallMolecule
cellular location: Nucleus
entity reference: Cytidine monophosphate N-acetylneuraminic acid

Reference/ChEBI CHEBI 63154
type: UnificationXref
id: CHEBI:63154
db: ChEBI

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/KEGG Compound C00461
type: UnificationXref
id: C00461
db: KEGG Compound

Reference/PubChem-compound 439174
type: UnificationXref
id: 439174
db: PubChem-compound

Reference/KEGG Compound C01674
type: UnificationXref
id: C01674
db: KEGG Compound

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 440273
type: UnificationXref
id: 440273
db: PubChem-compound

Reference/PubChem-compound 440272
type: UnificationXref
id: 440272
db: PubChem-compound

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Reference/ChEBI CHEBI 17029
type: UnificationXref
id: CHEBI:17029
db: ChEBI

Reference/ChemSpider 392810
type: UnificationXref
id: 392810
db: ChemSpider

Reference/ChemSpider 388319
type: UnificationXref
id: 388319
db: ChemSpider

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Reference/KEGG Compound C00352
type: UnificationXref
id: C00352
db: KEGG Compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00357
type: UnificationXref
id: C00357
db: KEGG Compound

Compound/PW C000192 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 131-48-6
type: UnificationXref
id: 131-48-6
db: CAS

Reference/ChemSpider 395082
type: UnificationXref
id: 395082
db: ChemSpider

Reference/BioCyc N-ACETYLNEURAMINATE
type: UnificationXref
id: N-ACETYLNEURAMINATE
db: BioCyc

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoenolpyruvic acid

Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Fructose 6-phosphate

D-Fructose
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-535
xref: Reference/ChEBI CHEBI 28645
xref: Reference/ChemSpider 388775
xref: Reference/PubChem-compound 439709
xref: Reference/KEGG Compound C02336
xref: Reference/HMDB HMDB0000660
xref: Reference/CAS 53188-23-1
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000517

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/CAS 3616-42-0
type: UnificationXref
id: 3616-42-0
db: CAS

Reference/KEGG Compound C00128
type: UnificationXref
id: C00128
db: KEGG Compound

N-Acetyl-D-mannosamine 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 62165
xref: Reference/ChemSpider 389249
xref: Reference/BioCyc N-ACETYL-D-MANNOSAMINE-6P
xref: Reference/PubChem-compound 440273
xref: Reference/CAS 873185-52-5
xref: Reference/HMDB HMDB0001121
xref: Reference/KEGG Compound C04257
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C000875

Reference/UniProt Q9CPT3
type: UnificationXref
id: Q9CPT3
db: UniProt

Compound/PW C000155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylneuraminic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

N-Acetylmannosamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00645
xref: Reference/BioCyc N-ACETYL-D-MANNOSAMINE
xref: Reference/PubChem-compound 11096158
xref: Reference/ChEBI CHEBI 63154
xref: Reference/ChemSpider 9271300
xref: Reference/HMDB HMDB0001129
xref: Reference/CAS 7772-94-3
chemical formula: C8H15NO6
molecular weight: 221.08994
structure: ChemicalStructure/PW C000883

Chitotriosidase-1
type: ProteinReference
xref: Reference/UniProt Q9D7Q1
organism: Mus musculus

Reference/ChemSpider 388775
type: UnificationXref
id: 388775
db: ChemSpider

N-acetyl-D-glucosamine kinase
type: Protein
cellular location: Cytoplasm
entity reference: N-acetyl-D-glucosamine kinase

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/UniProt Q3TW96
type: UnificationXref
id: Q3TW96
db: UniProt

3.1.3.29
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000155 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002695 Cytoplasm/Stoichiometry/1.0
right: N-Acetylneuraminic acid
right: Phosphate
spontaneous: false
EC number: 3.1.3.29
left: N-Acetylneuraminate 9-phosphate
left: Water
name: N-Acetylneuraminate 9-phosphate + Water → N-Acetylneuraminic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.7.43
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000057 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000155 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000912 Nucleus/Stoichiometry/1.0
right: Pyrophosphate
right: Cytidine monophosphate N-acetylneuraminic acid
spontaneous: false
EC number: 2.7.7.43
left: N-Acetylneuraminic acid
left: Cytidine triphosphate
name: Cytidine triphosphate + N-Acetylneuraminic acid ↔ Cytidine monophosphate N-acetylneuraminic acid + Pyrophosphate
conversion direction: REVERSIBLE

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Glucosamine 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 3616-42-0
xref: Reference/ChemSpider 388356
xref: Reference/ChEBI CHEBI 15873
xref: Reference/KEGG Compound C00352
xref: Reference/BioCyc D-GLUCOSAMINE-6-P
xref: Reference/PubChem-compound 439217
xref: Reference/HMDB HMDB0001254
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000969

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/ChEBI CHEBI 7125
type: UnificationXref
id: CHEBI:7125
db: ChEBI

Reference/KEGG Compound C00140
type: UnificationXref
id: C00140
db: KEGG Compound

Compound/PW C000057 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc D-GLUCOSAMINE-6-P
type: UnificationXref
id: D-GLUCOSAMINE-6-P
db: BioCyc

Phosphoacetylglucosamine mutase
type: ProteinReference
xref: Reference/UniProt Q9CYR6
organism: Mus musculus

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
type: ProteinReference
xref: Reference/UniProt Q91WG8
organism: Mus musculus

Sialic acid synthase
type: ProteinReference
xref: Reference/UniProt Q99J77
organism: Mus musculus

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid

N-Acetyl-D-mannosamine 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetyl-D-mannosamine 6-phosphate

N-acylglucosamine 2-epimerase
type: Protein
cellular location: Cytoplasm
entity reference: N-acylglucosamine 2-epimerase

Chitin
type: SmallMolecule
cellular location: Lysosome
entity reference: Chitin

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

3.2.1.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001925 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001858 Lysosome/Stoichiometry/1.0
right: Chitobiose
spontaneous: false
EC number: 3.2.1.14
left: Chitin
name: Chitin → Chitobiose
conversion direction: LEFT_TO_RIGHT

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

3.2.1.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000141 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001858 Lysosome/Stoichiometry/1.0
right: N-Acetyl-D-glucosamine
spontaneous: false
EC number: 3.2.1.14
left: Chitin
name: Chitin → N-Acetyl-D-glucosamine
conversion direction: LEFT_TO_RIGHT

5.4.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001055 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cytoplasm/Stoichiometry/1.0
right: N-Acetyl-glucosamine 1-phosphate
spontaneous: false
EC number: 5.4.2.3
left: N-Acetyl-D-Glucosamine 6-Phosphate
name: N-Acetyl-D-Glucosamine 6-Phosphate ↔ N-Acetyl-glucosamine 1-phosphate
conversion direction: REVERSIBLE

Solute carrier family 17 member 9
type: Protein
entity reference: Solute carrier family 17 member 9

Reaction109668
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000883 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000196 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytoplasm/Stoichiometry/1.0
right: N-Acetylmannosamine
right: Uridine 5'-diphosphate
spontaneous: false
left: Uridine diphosphate-N-acetylglucosamine
left: Water
name: Uridine diphosphate-N-acetylglucosamine + Water → N-Acetylmannosamine + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

2.7.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000079 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Fructose 6-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.1
left: D-Fructose
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000912
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Reference/UniProt Q9JK38
type: UnificationXref
id: Q9JK38
db: UniProt

2.7.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001167 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Glucosamine 6-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.1
left: Glucosamine
left: Adenosine triphosphate
name: Adenosine triphosphate + Glucosamine → Adenosine diphosphate + Glucosamine 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction109671
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000883 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000155 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
right: N-Acetylneuraminic acid
right: Phosphate
spontaneous: false
left: N-Acetylmannosamine
left: Water
left: Phosphoenolpyruvic acid
name: N-Acetylmannosamine + Phosphoenolpyruvic acid + Water → N-Acetylneuraminic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction109672
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000883 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000875 Cytoplasm/Stoichiometry/1.0
right: N-Acetyl-D-mannosamine 6-phosphate
right: Adenosine diphosphate
spontaneous: false
left: N-Acetylmannosamine
left: Adenosine triphosphate
name: Adenosine triphosphate + N-Acetylmannosamine → Adenosine diphosphate + N-Acetyl-D-mannosamine 6-phosphate
conversion direction: LEFT_TO_RIGHT

N-Acetyl-D-glucosamine
type: SmallMolecule
cellular location: Lysosome
entity reference: N-Acetyl-D-glucosamine

Reaction109673
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002695 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000875 Cytoplasm/Stoichiometry/1.0
right: N-Acetylneuraminate 9-phosphate
right: Phosphate
spontaneous: false
left: N-Acetyl-D-mannosamine 6-phosphate
left: Water
left: Phosphoenolpyruvic acid
name: N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvic acid + Water ↔ N-Acetylneuraminate 9-phosphate + Phosphate
conversion direction: REVERSIBLE

3.5.1.25
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cytoplasm/Stoichiometry/1.0
right: Glucosamine 6-phosphate
right: Acetic acid
spontaneous: false
EC number: 3.5.1.25
left: N-Acetyl-D-Glucosamine 6-Phosphate
left: Water
name: N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc N-ACETYL-D-MANNOSAMINE
type: UnificationXref
id: N-ACETYL-D-MANNOSAMINE
db: BioCyc

N-Acetylneuraminate 9-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetylneuraminate 9-phosphate

Reference/CAS 577-76-4
type: UnificationXref
id: 577-76-4
db: CAS

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/KEGG Compound C02336
type: UnificationXref
id: C02336
db: KEGG Compound

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-1-P
db: BioCyc

3.2.1.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001925 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141 Lysosome/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Lysosome/Stoichiometry/1.0
right: N-Acetyl-D-glucosamine
spontaneous: false
EC number: 3.2.1.52
left: Water
left: Chitobiose
name: Chitobiose + Water → 2 N-Acetyl-D-glucosamine
conversion direction: LEFT_TO_RIGHT

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

2.7.1.59
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000141 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: N-Acetyl-D-Glucosamine 6-Phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.59
left: N-Acetyl-D-glucosamine
left: Adenosine triphosphate
name: Adenosine triphosphate + N-Acetyl-D-glucosamine ↔ Adenosine diphosphate + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: REVERSIBLE

2.3.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cytoplasm/Stoichiometry/1.0
right: N-Acetyl-D-Glucosamine 6-Phosphate
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.4
left: Glucosamine 6-phosphate
left: Acetyl-CoA
name: Acetyl-CoA + Glucosamine 6-phosphate → Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: LEFT_TO_RIGHT

Glucosamine-6-phosphate isomerase 1
type: Complex
component stoichiometry: Protein/13643 Cytoplasm/Stoichiometry/6.0
cellular location: Cytoplasm
component: Glucosamine-6-phosphate isomerase 2

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

3.5.99.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Cytoplasm/Stoichiometry/1.0
right: Ammonia
right: Fructose 6-phosphate
spontaneous: false
EC number: 3.5.99.6
left: Glucosamine 6-phosphate
left: Water
name: Glucosamine 6-phosphate + Water → Ammonia + Fructose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Glucosamine 6-phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Glucosamine 6-phosphate

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

2.6.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000079 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Cytoplasm/Stoichiometry/1.0
right: Glucosamine 6-phosphate
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.16
left: L-Glutamine
left: Fructose 6-phosphate
name: Fructose 6-phosphate + L-Glutamine → Glucosamine 6-phosphate + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Protein/13646 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: N-acylglucosamine 2-epimerase
stoichiometric coefficient: 2.0

Reaction108554
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000196 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192 Cytoplasm/Stoichiometry/1.0
right: Uridine diphosphate-N-acetylglucosamine
right: Pyrophosphate
spontaneous: false
left: Uridine triphosphate
left: N-Acetyl-glucosamine 1-phosphate
name: N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00043
type: UnificationXref
id: C00043
db: KEGG Compound

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

5.1.3.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000883 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141 Cytoplasm/Stoichiometry/1.0
right: N-Acetylmannosamine
spontaneous: false
EC number: 5.1.3.8
left: N-Acetyl-D-glucosamine
name: N-Acetyl-D-glucosamine ↔ N-Acetylmannosamine
conversion direction: REVERSIBLE

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

4.1.3.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000883 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000155 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: N-Acetylmannosamine
spontaneous: false
EC number: 4.1.3.3
left: N-Acetylneuraminic acid
name: N-Acetylneuraminic acid → N-Acetylmannosamine + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Uridine 5'-diphosphate

Reference/PubChem-compound 53477814
type: UnificationXref
id: 53477814
db: PubChem-compound

Compound/PW C000155 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylneuraminic acid
stoichiometric coefficient: 1.0

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/ChemSpider 389821
type: UnificationXref
id: 389821
db: ChemSpider

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Fructose 6-phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Fructose 6-phosphate

Reference/ChEBI CHEBI 47977
type: UnificationXref
id: CHEBI:47977
db: ChEBI

Reference/ChemSpider 399508
type: UnificationXref
id: 399508
db: ChemSpider

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine diphosphate

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Chitin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17029
xref: Reference/ChemSpider 399508
xref: Reference/HMDB HMDB0003362
xref: Reference/CAS 1398-61-4
xref: Reference/KEGG Compound C00461
xref: Reference/PubChem-compound 21252321
xref: Reference/BioCyc 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
chemical formula: C24H41N3O16
molecular weight: 627.24866
structure: ChemicalStructure/PW C001858

Reference/PubChem-compound 11096158
type: UnificationXref
id: 11096158
db: PubChem-compound

Reference/HMDB HMDB0001367
type: UnificationXref
id: HMDB0001367
db: HMDB

N-Acetylneuraminic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetylneuraminic acid

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/HMDB HMDB0001129
type: UnificationXref
id: HMDB0001129
db: HMDB

ChemicalStructure/PW C000155
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002695
type: ChemicalStructure
structure format: SMILES

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/BioCyc 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
type: UnificationXref
id: 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
db: BioCyc

Reference/HMDB HMDB0001121
type: UnificationXref
id: HMDB0001121
db: HMDB

Beta-hexosaminidase subunit beta
type: Protein
cellular location: Lysosome
entity reference: Beta-hexosaminidase subunit beta

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Uridine diphosphate-N-acetylglucosamine

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Hexokinase-1
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Hexokinase-1

Reference/PubChem-compound 445675
type: UnificationXref
id: 445675
db: PubChem-compound

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/CAS 6866-69-9
type: UnificationXref
id: 6866-69-9
db: CAS

Compound/PW C002695 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylneuraminate 9-phosphate
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0003556
type: UnificationXref
id: HMDB0003556
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Reference/SMPDB SMP0120599
type: UnificationXref
id: SMP0120599
db: SMPDB

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Compound/PW C000837 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001254
type: UnificationXref
id: HMDB0001254
db: HMDB

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/KEGG Compound C19910
type: UnificationXref
id: C19910
db: KEGG Compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Glucosamine 6-phosphate N-acetyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Glucosamine 6-phosphate N-acetyltransferase

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Reference/HMDB HMDB0000290
type: UnificationXref
id: HMDB0000290
db: HMDB

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/ChEBI CHEBI 45744
type: UnificationXref
id: CHEBI:45744
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Compound/PW C001055 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-glucosamine 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/PubChem-compound 22833609
type: UnificationXref
id: 22833609
db: PubChem-compound

Reference/UniProt P17710
type: UnificationXref
id: P17710
db: UniProt

Protein/13934 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
stoichiometric coefficient: 2.0

Reference/BioCyc CMP-N-ACETYL-NEURAMINATE
type: UnificationXref
id: CMP-N-ACETYL-NEURAMINATE
db: BioCyc

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Glucosamine 6-phosphate N-acetyltransferase
type: Complex
component stoichiometry: Protein/13642 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glucosamine 6-phosphate N-acetyltransferase

Reference/UniProt P82343
type: UnificationXref
id: P82343
db: UniProt

ChemicalStructure/PW C000196
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Glucosamine-6-phosphate isomerase 2
type: Protein
cellular location: Cytoplasm
entity reference: Glucosamine-6-phosphate isomerase 2

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001167
type: ChemicalStructure
structure format: SMILES
structure data: N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O

Glucosamine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Glucosamine

Transport1041
type: Transport
participant stoichiometry: Compound/PW C000155 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000155 Cytosol/Stoichiometry/1.0
right: N-Acetylneuraminic acid
spontaneous: false
left: N-Acetylneuraminic acid
name: N-Acetylneuraminic acid (↔) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Cell, Lysosome
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7772-94-3
type: UnificationXref
id: 7772-94-3
db: CAS

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Protein/13649 Nucleus/Stoichiometry/4.0
type: Stoichiometry
physical entity: N-acylneuraminate cytidylyltransferase
stoichiometric coefficient: 4.0

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

ReactionCatalysis98709
type: Catalysis
controller: Glutamine--fructose-6-phosphate aminotransferase
controlled: 2.6.1.16
control type: ACTIVATION

G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease
type: Pathway
pathway order: PathwayEnzymeReaction/2110890
pathway order: PathwayEnzymeReaction/2110892
pathway order: PathwayEnzymeReaction/2110891
pathway order: PathwayEnzymeReaction/2110894
pathway order: PathwayEnzymeReaction/2110893
pathway order: PathwayEnzymeReaction/2110896
pathway order: PathwayEnzymeReaction/2110895
pathway order: PathwayEnzymeReaction/2110887
pathway order: PathwayEnzymeReaction/2110898
pathway order: PathwayEnzymeReaction/2110897
pathway order: PathwayEnzymeReaction/2110889
pathway order: PathwayEnzymeReaction/2110900
pathway order: PathwayEnzymeReaction/2110888
pathway order: PathwayEnzymeReaction/2110899
pathway order: PathwayEnzymeReaction/2110902
pathway order: PathwayEnzymeReaction/2110901
pathway order: PathwayEnzymeReaction/2110904
pathway order: PathwayEnzymeReaction/2110903
pathway order: PathwayEnzymeReaction/2110906
pathway order: PathwayEnzymeReaction/2110905
pathway order: PathwayTransport/2110907
pathway component: 3.5.1.25
pathway component: ReactionCatalysis99928
pathway component: ReactionCatalysis99929
pathway component: ReactionCatalysis99926
pathway component: ReactionCatalysis99927
pathway component: ReactionCatalysis98717
pathway component: 3.1.3.29
pathway component: ReactionCatalysis99925
pathway component: 2.7.7.43
pathway component: ReactionCatalysis98712
pathway component: 3.2.1.52
pathway component: ReactionCatalysis98711
pathway component: 2.7.1.59
pathway component: 2.3.1.4
pathway component: 3.5.99.6
pathway component: Transport1041
pathway component: ReactionCatalysis98709
pathway component: ReactionCatalysis98707
pathway component: ReactionCatalysis98708
pathway component: ReactionCatalysis98705
pathway component: ReactionCatalysis98706
pathway component: ReactionCatalysis98703
pathway component: 2.6.1.16
pathway component: 3.2.1.14
pathway component: Reaction108554
pathway component: ReactionCatalysis99933
pathway component: 5.1.3.8
pathway component: 5.4.2.3
pathway component: ReactionCatalysis99931
pathway component: ReactionCatalysis98721
pathway component: Reaction109668
pathway component: ReactionCatalysis99932
pathway component: 2.7.1.1
pathway component: ReactionCatalysis99930
pathway component: ReactionCatalysis98720
pathway component: Reaction109671
pathway component: 4.1.3.3
pathway component: TransportCatalysis924
pathway component: Reaction109672
pathway component: Reaction109673
xref: Reference/SMPDB SMP0120599
xref: Reference/PathWhiz PW121855
organism: Mus musculus

ReactionCatalysis98707
type: Catalysis
controller: Glucosamine 6-phosphate N-acetyltransferase
controlled: 2.3.1.4
control type: ACTIVATION

Compound/PW C000079 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis98708
type: Catalysis
controller: Glucosamine-6-phosphate isomerase 1
controlled: 3.5.99.6
control type: ACTIVATION

ReactionCatalysis98705
type: Catalysis
controller: N-acetyl-D-glucosamine kinase
controlled: 2.7.1.59
control type: ACTIVATION

ReactionCatalysis98706
type: Catalysis
controller: N-acetylglucosamine-6-phosphate deacetylase
controlled: 3.5.1.25
control type: ACTIVATION

ReactionCatalysis98703
type: Catalysis
controller: Beta-hexosaminidase subunit beta
controlled: 3.2.1.52
control type: ACTIVATION

Reference/CAS 102029-88-9
type: UnificationXref
id: 102029-88-9
db: CAS

Compound/PW C001420 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C001858 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chitin
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001055
type: ChemicalStructure
structure format: SMILES

N-Acetyl-D-glucosamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetyl-D-glucosamine

Reference/CAS 3063-71-6
type: UnificationXref
id: 3063-71-6
db: CAS

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Compound/PW C000517 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Fructose
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001176
type: UnificationXref
id: HMDB0001176
db: HMDB

Reference/UniProt Q9DCJ9
type: UnificationXref
id: Q9DCJ9
db: UniProt

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/BioCyc CPD-535
type: UnificationXref
id: CPD-535
db: BioCyc

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Reference/UniProt Q9QZ08
type: UnificationXref
id: Q9QZ08
db: UniProt

N-Acetylmannosamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetylmannosamine

N-Acetylneuraminate 9-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06241
xref: Reference/HMDB HMDB0006268
xref: Reference/PubChem-compound 53477814
xref: Reference/ChemSpider 30776539
chemical formula: C11H20NO12P
molecular weight: 389.07233
structure: ChemicalStructure/PW C002695

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Chitobiose
type: SmallMolecule
cellular location: Lysosome
entity reference: Chitobiose

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

N-Acetylneuraminic acid
type: SmallMoleculeReference
xref: Reference/CAS 131-48-6
xref: Reference/PubChem-compound 445063
xref: Reference/ChEBI CHEBI 45744
xref: Reference/ChemSpider 392810
xref: Reference/BioCyc N-ACETYLNEURAMINATE
xref: Reference/HMDB HMDB0000230
xref: Reference/KEGG Compound C19910
chemical formula: C11H19NO9
molecular weight: 309.106
structure: ChemicalStructure/PW C000155

Reference/PubChem-compound 21252321
type: UnificationXref
id: 21252321
db: PubChem-compound

UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
type: Protein
cellular location: Cytoplasm
entity reference: UDP-N-acetylhexosamine pyrophosphorylase-like protein 1

Reference/PubChem-compound 439709
type: UnificationXref
id: 439709
db: PubChem-compound

Reference/BioCyc N-ACETYL-D-MANNOSAMINE-6P
type: UnificationXref
id: N-ACETYL-D-MANNOSAMINE-6P
db: BioCyc

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Compound/PW C000912 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate N-acetylneuraminic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Reference/PubChem-compound 448209
type: UnificationXref
id: 448209
db: PubChem-compound

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

Reference/CAS 528-04-1
type: UnificationXref
id: 528-04-1
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/HMDB HMDB0001514
type: UnificationXref
id: HMDB0001514
db: HMDB

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/HMDB HMDB0000660
type: UnificationXref
id: HMDB0000660
db: HMDB

N-Acetylneuraminic acid
type: SmallMolecule
cellular location: Lysosome
entity reference: N-Acetylneuraminic acid

Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
type: UnificationXref
id: ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
db: BioCyc

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Lysosome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005764

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-6-P
db: BioCyc

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/UniProt Q9D7Q1
type: UnificationXref
id: Q9D7Q1
db: UniProt

Reference/KEGG Compound C04256
type: UnificationXref
id: C04256
db: KEGG Compound

N-acetylneuraminate lyase
type: Protein
cellular location: Cytoplasm
entity reference: N-acetylneuraminate lyase

Reference/KEGG Compound C04257
type: UnificationXref
id: C04257
db: KEGG Compound

Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 393240
type: UnificationXref
id: 393240
db: ChemSpider

Reference/BioCyc CHITOBIOSE
type: UnificationXref
id: CHITOBIOSE
db: BioCyc

Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Glucosamine 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glucosamine 6-phosphate

Protein/13642 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate N-acetyltransferase
stoichiometric coefficient: 2.0

Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Reference/UniProt Q99J77
type: UnificationXref
id: Q99J77
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

D-Fructose
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: D-Fructose

Compound/PW C000141 Lysosome/Stoichiometry/2.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA

N-Acetyl-D-glucosamine
type: SmallMoleculeReference
xref: Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
xref: Reference/ChEBI CHEBI 506227
xref: Reference/HMDB HMDB0000215
xref: Reference/KEGG Compound C00140
xref: Reference/ChemSpider 388319
xref: Reference/PubChem-compound 439174
xref: Reference/CAS 7512-17-6
chemical formula: C8H15NO6
molecular weight: 221.08994
structure: ChemicalStructure/PW C000141

N-acetyl-D-glucosamine kinase
type: Complex
component stoichiometry: Protein/13640 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: N-acetyl-D-glucosamine kinase

Hexokinase-1
type: ProteinReference
xref: Reference/UniProt P17710
organism: Mus musculus

Reference/CAS 873185-52-5
type: UnificationXref
id: 873185-52-5
db: CAS

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/HMDB HMDB0000215
type: UnificationXref
id: HMDB0000215
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/UniProt Q8VCL5
type: UnificationXref
id: Q8VCL5
db: UniProt

Glucosamine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439213
xref: Reference/ChEBI CHEBI 47977
xref: Reference/HMDB HMDB0001514
xref: Reference/CAS 3416-24-8
xref: Reference/KEGG Compound C00329
xref: Reference/ChemSpider 388352
xref: Reference/BioCyc GLUCOSAMINE
chemical formula: C6H13NO5
molecular weight: 179.07938
structure: ChemicalStructure/PW C001167

Reference/CAS 1398-61-4
type: UnificationXref
id: 1398-61-4
db: CAS

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Reference/GENE ONTOLOGY GO 0005764
type: UnificationXref
id: GO:0005764
db: GENE ONTOLOGY

Uridine diphosphate-N-acetylglucosamine
type: SmallMoleculeReference
xref: Reference/CAS 528-04-1
xref: Reference/PubChem-compound 445675
xref: Reference/HMDB HMDB0000290
xref: Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
xref: Reference/KEGG Compound C00043
xref: Reference/ChEBI CHEBI 16264
xref: Reference/ChemSpider 393240
chemical formula: C17H27N3O17P2
molecular weight: 607.08154
structure: ChemicalStructure/PW C000196

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

N-acetylglucosamine-6-phosphate deacetylase
type: Protein
cellular location: Cytoplasm
entity reference: N-acetylglucosamine-6-phosphate deacetylase

ChemicalStructure/PW C000141
type: ChemicalStructure
structure format: SMILES

N-Acetyl-glucosamine 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 7125
xref: Reference/ChemSpider 389248
xref: Reference/HMDB HMDB0001367
xref: Reference/PubChem-compound 440272
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
xref: Reference/CAS 6866-69-9
xref: Reference/KEGG Compound C04256
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C001055

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

N-acylglucosamine 2-epimerase
type: Complex
component stoichiometry: Protein/13646 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: N-acylglucosamine 2-epimerase

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Reference/PubChem-compound 445063
type: UnificationXref
id: 445063
db: PubChem-compound

Bifunctional UDP-N-acetyl glucosamine 2-epimerase / N-acetylmannosamine kinase
type: Complex
component stoichiometry: Protein/13934 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/UniProt P20060
type: UnificationXref
id: P20060
db: UniProt

Reference/UniProt Q91WG8
type: UnificationXref
id: Q91WG8
db: UniProt

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/KEGG Compound C06241
type: UnificationXref
id: C06241
db: KEGG Compound

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000230
type: UnificationXref
id: HMDB0000230
db: HMDB

Reference/ChEBI CHEBI 15873
type: UnificationXref
id: CHEBI:15873
db: ChEBI

N-Acetylneuraminic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetylneuraminic acid

Reference/PubChem-compound 440996
type: UnificationXref
id: 440996
db: PubChem-compound

Uridine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Uridine triphosphate

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Coenzyme A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Coenzyme A

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000969
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/ChEBI CHEBI 28645
type: UnificationXref
id: CHEBI:28645
db: ChEBI

Compound/PW C001925 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chitobiose
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

N-acetylneuraminate lyase
type: Complex
component stoichiometry: Protein/13647 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: N-acetylneuraminate lyase

Reference/UniProt Q9CRC9
type: UnificationXref
id: Q9CRC9
db: UniProt

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Sialic acid synthase
type: Protein
cellular location: Cytoplasm
entity reference: Sialic acid synthase

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/UniProt Q9CYR6
type: UnificationXref
id: Q9CYR6
db: UniProt

Compound/PW C000883 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylmannosamine
stoichiometric coefficient: 1.0

Compound/PW C000170 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000201 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15784
type: UnificationXref
id: CHEBI:15784
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Compound/PW C000155 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylneuraminic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439213
type: UnificationXref
id: 439213
db: PubChem-compound

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/CAS 3416-24-8
type: UnificationXref
id: 3416-24-8
db: CAS

Reference/PubChem-compound 439217
type: UnificationXref
id: 439217
db: PubChem-compound

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Lysosome
entity reference: Water

Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
type: UnificationXref
id: UDP-N-ACETYL-D-GLUCOSAMINE
db: BioCyc

ChemicalStructure/PW C000837
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001925
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/BioCyc GLUCOSAMINE
type: UnificationXref
id: GLUCOSAMINE
db: BioCyc

Reference/ChEBI CHEBI 506227
type: UnificationXref
id: CHEBI:506227
db: ChEBI

Reference/HMDB HMDB0006268
type: UnificationXref
id: HMDB0006268
db: HMDB

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/ChemSpider 389249
type: UnificationXref
id: 389249
db: ChemSpider

Reference/ChemSpider 389248
type: UnificationXref
id: 389248
db: ChemSpider

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
type: Protein
cellular location: Cytoplasm
entity reference: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001858
type: ChemicalStructure
structure format: SMILES

Compound/PW C000079 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

N-Acetyl-glucosamine 1-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetyl-glucosamine 1-phosphate

Beta-hexosaminidase subunit beta
type: ProteinReference
xref: Reference/UniProt P20060
organism: Mus musculus

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Compound/PW C001167 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Glucosamine-6-phosphate isomerase 2
type: ProteinReference
xref: Reference/UniProt Q9CRC9
organism: Mus musculus

N-acylneuraminate-9-phosphatase
type: Protein
cellular location: Cytoplasm
entity reference: N-acylneuraminate-9-phosphatase

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
type: ProteinReference
xref: Reference/UniProt Q9Z2Z9
organism: Mus musculus

Cytidine monophosphate N-acetylneuraminic acid
type: SmallMoleculeReference
xref: Reference/BioCyc CMP-N-ACETYL-NEURAMINATE
xref: Reference/KEGG Compound C00128
xref: Reference/ChEBI CHEBI 16556
xref: Reference/CAS 3063-71-6
xref: Reference/ChemSpider 395082
xref: Reference/PubChem-compound 448209
xref: Reference/HMDB HMDB0001176
chemical formula: C20H31N4O16P
molecular weight: 614.1473
structure: ChemicalStructure/PW C000912

N-acetylglucosamine-6-phosphate deacetylase
type: ProteinReference
xref: Reference/UniProt Q8JZV7
organism: Mus musculus

Reference/KEGG Compound C00645
type: UnificationXref
id: C00645
db: KEGG Compound

Glucosamine 6-phosphate N-acetyltransferase
type: ProteinReference
xref: Reference/UniProt Q9JK38
organism: Mus musculus

N-acetyl-D-glucosamine kinase
type: ProteinReference
xref: Reference/UniProt Q9QZ08
organism: Mus musculus

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Compound/PW C000141 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 1.0

N-acylneuraminate cytidylyltransferase
type: ProteinReference
xref: Reference/UniProt Q99KK2
organism: Mus musculus

Compound/PW C000141 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 1.0

N-acetylneuraminate lyase
type: ProteinReference
xref: Reference/UniProt Q9DCJ9
organism: Mus musculus

N-acylneuraminate-9-phosphatase
type: ProteinReference
xref: Reference/UniProt Q9CPT3
organism: Mus musculus

UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
type: ProteinReference
xref: Reference/UniProt Q3TW96
organism: Mus musculus

N-acylneuraminate cytidylyltransferase
type: Protein
cellular location: Nucleus
entity reference: N-acylneuraminate cytidylyltransferase

Protein/13643 Cytoplasm/Stoichiometry/6.0
type: Stoichiometry
physical entity: Glucosamine-6-phosphate isomerase 2
stoichiometric coefficient: 6.0

N-acylglucosamine 2-epimerase
type: ProteinReference
xref: Reference/UniProt P82343
organism: Mus musculus

Protein/13640 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: N-acetyl-D-glucosamine kinase
stoichiometric coefficient: 2.0

Reference/UniProt Q9Z2Z9
type: UnificationXref
id: Q9Z2Z9
db: UniProt

Reference/ChEBI CHEBI 16556
type: UnificationXref
id: CHEBI:16556
db: ChEBI

Solute carrier family 17 member 9
type: ProteinReference
xref: Reference/UniProt Q8VCL5

Acetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetic acid

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Compound/PW C000969 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 30776539
type: UnificationXref
id: 30776539
db: ChemSpider

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Phosphoacetylglucosamine mutase
type: Protein
cellular location: Cytoplasm
entity reference: Phosphoacetylglucosamine mutase

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Chitotriosidase-1
type: Protein
cellular location: Lysosome
entity reference: Chitotriosidase-1

N-Acetylneuraminic acid
type: SmallMolecule
cellular location: Nucleus
entity reference: N-Acetylneuraminic acid

ChemicalStructure/PW C000875
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

ChemicalStructure/PW C000517
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO

Compound/PW C000875 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-mannosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

ChemicalStructure/PW C000883
type: ChemicalStructure
structure format: SMILES

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/UniProt Q8JZV7
type: UnificationXref
id: Q8JZV7
db: UniProt

Reference/CAS 7512-17-6
type: UnificationXref
id: 7512-17-6
db: CAS

Protein/13647 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: N-acetylneuraminate lyase
stoichiometric coefficient: 4.0