Protein/13908 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glutaryl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 17220838
type: UnificationXref
id: 17220838
db: ChemSpider

Reference/KEGG Compound C00318
type: UnificationXref
id: C00318
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

(2E)-Decenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Decenoyl-CoA

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: L-Carnitine

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/13901 Mitochondrial Inner Membrane/Stoichiometry/2.0
cellular location: Mitochondrial Inner Membrane
component: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced electron-transfer flavoprotein
stoichiometric coefficient: 1.0

Compound/PW C000032 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Lauroyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc LAUROYLCOA-CPD
xref: Reference/KEGG Compound C01832
xref: Reference/ChEBI CHEBI 15521
xref: Reference/HMDB HMDB0003571
xref: Reference/CAS 6244-92-4
xref: Reference/ChemSpider 145018
xref: Reference/PubChem-compound 165436
chemical formula: C33H56N7O17P3S
molecular weight: 947.2666
structure: ChemicalStructure/PW C001928

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/CAS 38795-33-4
type: UnificationXref
id: 38795-33-4
db: CAS

Hexanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hexanoyl-CoA

Reference/HMDB HMDB0001070
type: UnificationXref
id: HMDB0001070
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt P45952
type: UnificationXref
id: P45952
db: UniProt

Compound/PW C002007 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxohexanoyl-CoA
stoichiometric coefficient: 1.0

Reduced electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Reduced electron-transfer flavoprotein

Reference/HMDB HMDB0006404
type: UnificationXref
id: HMDB0006404
db: HMDB

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000147 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Palmitoylcarnitine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006402
type: UnificationXref
id: HMDB0006402
db: HMDB

Compound/PW C000147 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Palmitoylcarnitine
stoichiometric coefficient: 1.0

Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway107913
pathway component: SubPathwayInteraction107913
xref: Reference/SMPDB SMP0087235
xref: Reference/PathWhiz PW088254
name: SubPathway

Tetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Tetradecanoyl-CoA

ReactionCatalysis99949
type: Catalysis
controller: Acetyl-CoA acyltransferase
controlled: 2.3.1.16
control type: ACTIVATION

ReactionCatalysis99946
type: Catalysis
controller: Acetyl-CoA acyltransferase
controlled: 2.3.1.16
control type: ACTIVATION

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/BioCyc CPD-196
type: UnificationXref
id: CPD-196
db: BioCyc

ReactionCatalysis99942
type: Catalysis
controller: Carnitine O-palmitoyltransferase 2, mitochondrial
controlled: 2.3.1.21
control type: ACTIVATION

Reference/KEGG Compound C02990
type: UnificationXref
id: C02990
db: KEGG Compound

ReactionCatalysis99943
type: Catalysis
controller: Acetyl-CoA acyltransferase
controlled: 2.3.1.16
control type: ACTIVATION

Acetyl-CoA acyltransferase
type: Complex
component stoichiometry: Protein/7725 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Unknown

ReactionCatalysis99941
type: Catalysis
controller: Carnitine O-palmitoyltransferase 1
controlled: 2.3.1.21
control type: ACTIVATION

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/PubChem-compound 11966197
type: UnificationXref
id: 11966197
db: PubChem-compound

Reference/PubChem-compound 440045
type: UnificationXref
id: 440045
db: PubChem-compound

Compound/Generic69 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: electron-transfer flavoprotein
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001088
type: UnificationXref
id: HMDB0001088
db: HMDB

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/CAS 2364-67-2
type: UnificationXref
id: 2364-67-2
db: CAS

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Carbon dioxide

ReactionCatalysis99838
type: Catalysis
controller: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.9
control type: ACTIVATION

Reference/BioCyc 7-METHYL-3-OXOOCTANOYL-COA
type: UnificationXref
id: 7-METHYL-3-OXOOCTANOYL-COA
db: BioCyc

ReactionCatalysis99839
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.9
control type: ACTIVATION

ReactionCatalysis99958
type: Catalysis
controller: Acetyl-CoA acyltransferase
controlled: 2.3.1.16
control type: ACTIVATION

ReactionCatalysis99955
type: Catalysis
controller: Acetyl-CoA acyltransferase
controlled: 2.3.1.16
control type: ACTIVATION

Reduced electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Reduced electron-transfer flavoprotein

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ReactionCatalysis99952
type: Catalysis
controller: Acetyl-CoA acyltransferase
controlled: 2.3.1.16
control type: ACTIVATION

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis99840
type: Catalysis
controller: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.9
control type: ACTIVATION

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

(2E)-Octenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Octenoyl-CoA

Reference/UniProt P41216
type: UnificationXref
id: P41216
db: UniProt

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Hexanoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002845
xref: Reference/KEGG Compound C05270
xref: Reference/ChemSpider 395736
xref: Reference/CAS 5060-32-2
xref: Reference/PubChem-compound 449118
xref: Reference/ChEBI CHEBI 27540
chemical formula: C27H46N7O17P3S
molecular weight: 865.18835
structure: ChemicalStructure/PW C001719

ReactionCatalysis99849
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109622
control type: ACTIVATION

ReactionCatalysis99847
type: Catalysis
controller: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109620
control type: ACTIVATION

ReactionCatalysis99845
type: Catalysis
controller: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109619
control type: ACTIVATION

ReactionCatalysis99846
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109620
control type: ACTIVATION

ReactionCatalysis99843
type: Catalysis
controller: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109618
control type: ACTIVATION

Reference/ChEBI CHEBI 5086
type: UnificationXref
id: CHEBI:5086
db: ChEBI

ReactionCatalysis99844
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109619
control type: ACTIVATION

ReactionCatalysis99842
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109618
control type: ACTIVATION

Reference/BioCyc LAUROYLCOA-CPD
type: UnificationXref
id: LAUROYLCOA-CPD
db: BioCyc

ReactionCatalysis99850
type: Catalysis
controller: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: Reaction109622
control type: ACTIVATION

ReactionCatalysis99851
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

Lauroyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Lauroyl-CoA

2.3.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000044 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000147 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000147 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: L-Palmitoylcarnitine
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.21
left: L-Carnitine
left: Palmityl-CoA
name: L-Carnitine + Palmityl-CoA ↔ Coenzyme A + L-Palmitoylcarnitine
conversion direction: REVERSIBLE

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002740 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001171 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: 3-Oxohexadecanoyl-CoA
spontaneous: false
EC number: 2.3.1.16
left: Acetyl-CoA
left: Tetradecanoyl-CoA
name: Acetyl-CoA + Tetradecanoyl-CoA ↔ 3-Oxohexadecanoyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001999 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001928 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-Oxotetradecanoyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.16
left: Lauroyl-CoA
left: Acetyl-CoA
name: Acetyl-CoA + Lauroyl-CoA → 3-Oxotetradecanoyl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002742 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002001 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: 3-Oxododecanoyl-CoA
spontaneous: false
EC number: 2.3.1.16
left: Acetyl-CoA
left: Decanoyl-CoA
name: Acetyl-CoA + Decanoyl-CoA → 3-Oxododecanoyl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 53477508
type: UnificationXref
id: 53477508
db: PubChem-compound

Trifunctional enzyme subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8BMS1
organism: Mus musculus

Reference/KEGG Compound C00249
type: UnificationXref
id: C00249
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000845 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002003 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: 3-Oxodecanoyl-CoA
spontaneous: false
EC number: 2.3.1.16
left: Acetyl-CoA
left: Octanoyl-CoA
name: Acetyl-CoA + Octanoyl-CoA ↔ 3-Oxodecanoyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002005 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001719 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: 3-Oxooctanoyl-CoA
spontaneous: false
EC number: 2.3.1.16
left: Acetyl-CoA
left: Hexanoyl-CoA
name: Acetyl-CoA + Hexanoyl-CoA ↔ 3-Oxooctanoyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000856 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002007 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-Oxohexanoyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.16
left: Acetyl-CoA
left: Butyryl-CoA
name: Acetyl-CoA + Butyryl-CoA → 3-Oxohexanoyl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis99856
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ReactionCatalysis99857
type: Catalysis
controller: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

ReactionCatalysis99854
type: Catalysis
controller: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

ReactionCatalysis99855
type: Catalysis
controller: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

ReactionCatalysis99852
type: Catalysis
controller: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ReactionCatalysis99853
type: Catalysis
controller: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

Protein/13901 Mitochondrial Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

ReactionCatalysis99861
type: Catalysis
controller: Glutaryl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.6
control type: ACTIVATION

ReactionCatalysis99862
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: Reaction109628
control type: ACTIVATION

Reference/CAS 103192-48-9
type: UnificationXref
id: 103192-48-9
db: CAS

ReactionCatalysis99860
type: Catalysis
controller: Long-chain-fatty-acid--CoA ligase 1
controlled: 6.2.1.3
control type: ACTIVATION

L-Palmitoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: L-Palmitoylcarnitine

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: L-Carnitine

Reference/ChEBI CHEBI 28276
type: UnificationXref
id: CHEBI:28276
db: ChEBI

Reference/CAS 3130-72-1
type: UnificationXref
id: 3130-72-1
db: CAS

Reference/ChemSpider 389502
type: UnificationXref
id: 389502
db: ChemSpider

Reference/ChemSpider 389501
type: UnificationXref
id: 389501
db: ChemSpider

Octanoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01944
xref: Reference/ChEBI CHEBI 15533
xref: Reference/HMDB HMDB0001070
xref: Reference/ChemSpider 371
xref: Reference/BioCyc CPD-196
xref: Reference/PubChem-compound 380
xref: Reference/CAS 1264-52-4
chemical formula: C29H50N7O17P3S
molecular weight: 893.21967
structure: ChemicalStructure/PW C000845

Reference/ChemSpider 389500
type: UnificationXref
id: 389500
db: ChemSpider

ChemicalStructure/PW C000904
type: ChemicalStructure
structure format: SMILES

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Reference/ChemSpider 389506
type: UnificationXref
id: 389506
db: ChemSpider

Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChemSpider 389504
type: UnificationXref
id: 389504
db: ChemSpider

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

ReactionCatalysis99867
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: Reaction109631
control type: ACTIVATION

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

ReactionCatalysis99868
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: Reaction109632
control type: ACTIVATION

ReactionCatalysis99865
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: Reaction109630
control type: ACTIVATION

Reference/PubChem-compound 11966160
type: UnificationXref
id: 11966160
db: PubChem-compound

Reference/PathWhiz PW121865
type: UnificationXref
id: PW121865
db: PathWhiz

Reference/KEGG Compound C00136
type: UnificationXref
id: C00136
db: KEGG Compound

Reaction109658
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
name: 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

ReactionCatalysis99873
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: Reaction109635
control type: ACTIVATION

ReactionCatalysis99870
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: Reaction109633
control type: ACTIVATION

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/13903 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 10723
type: UnificationXref
id: CHEBI:10723
db: ChEBI

Reference/ChemSpider 389508
type: UnificationXref
id: 389508
db: ChemSpider

Reference/ChEBI CHEBI 28264
type: UnificationXref
id: CHEBI:28264
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/BioCyc CARNITINE
type: UnificationXref
id: CARNITINE
db: BioCyc

Butyryl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 2140-48-9
xref: Reference/ChEBI CHEBI 57371
xref: Reference/ChemSpider 260
xref: Reference/PubChem-compound 265
xref: Reference/KEGG Compound C00136
xref: Reference/BioCyc CPD-12174
xref: Reference/HMDB HMDB0001088
chemical formula: C25H42N7O17P3S
molecular weight: 837.15704
structure: ChemicalStructure/PW C000856

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

ReactionCatalysis99879
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction109640
control type: ACTIVATION

ReactionCatalysis99876
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction109638
control type: ACTIVATION

Reference/ChemSpider 389510
type: UnificationXref
id: 389510
db: ChemSpider

Compound/PW C001719 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hexanoyl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis99874
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: Reaction109636
control type: ACTIVATION

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

3-Hydroxydecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxydecanoyl-CoA

ReactionCatalysis99883
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction109643
control type: ACTIVATION

Reference/CAS 1264-57-9
type: UnificationXref
id: 1264-57-9
db: CAS

Reference/ChEBI CHEBI 17490
type: UnificationXref
id: CHEBI:17490
db: ChEBI

Reference/ChEBI CHEBI 28493
type: UnificationXref
id: CHEBI:28493
db: ChEBI

Adenosine monophosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine monophosphate

Reference/CAS 4460-95-1
type: UnificationXref
id: 4460-95-1
db: CAS

Reaction109638
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002740 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001996 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-Oxohexadecanoyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
left: 3-Hydroxyhexadecanoyl-CoA
left: NAD
name: 3-Hydroxyhexadecanoyl-CoA + NAD ↔ 3-Oxohexadecanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/CAS 72059-49-5
type: UnificationXref
id: 72059-49-5
db: CAS

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/13905 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

L-Palmitoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: L-Palmitoylcarnitine

3-Oxohexadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Oxohexadecanoyl-CoA

Reaction109630
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001998 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002010 Mitochondrial Matrix/Stoichiometry/1.0
right: Water
right: (2E)-Tetradecenoyl-CoA
spontaneous: false
left: 3-Hydroxytetradecanoyl-CoA
name: 3-Hydroxytetradecanoyl-CoA ↔ (2E)-Tetradecenoyl-CoA + Water
conversion direction: REVERSIBLE

Reference/KEGG Compound C00154
type: UnificationXref
id: C00154
db: KEGG Compound

3-Hydroxyhexadecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27402
xref: Reference/HMDB HMDB0003932
xref: Reference/CAS 35106-50-4
xref: Reference/ChemSpider 389498
xref: Reference/PubChem-compound 440600
xref: Reference/KEGG Compound C05258
chemical formula: C37H66N7O18P3S
molecular weight: 1021.3398
structure: ChemicalStructure/PW C001996

Reaction109631
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002010 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002000 Mitochondrial Matrix/Stoichiometry/1.0
right: Water
right: (2E)-Tetradecenoyl-CoA
spontaneous: false
left: 3-Hydroxydodecanoyl-CoA
name: 3-Hydroxydodecanoyl-CoA → (2E)-Tetradecenoyl-CoA + Water
conversion direction: LEFT_TO_RIGHT

Reaction109632
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002002 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002012 Mitochondrial Matrix/Stoichiometry/1.0
right: (2E)-Decenoyl-CoA
right: Water
spontaneous: false
left: 3-Hydroxydecanoyl-CoA
name: 3-Hydroxydecanoyl-CoA ↔ (2E)-Decenoyl-CoA + Water
conversion direction: REVERSIBLE

3-Hydroxytetradecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27466
xref: Reference/ChemSpider 389500
xref: Reference/HMDB HMDB0003934
xref: Reference/KEGG Compound C05260
xref: Reference/PubChem-compound 440602
chemical formula: C35H62N7O18P3S
molecular weight: 993.3085
structure: ChemicalStructure/PW C001998

Reaction109633
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002013 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002004 Mitochondrial Matrix/Stoichiometry/1.0
right: Water
right: (2E)-Octenoyl-CoA
spontaneous: false
left: 3-Hydroxyoctanoyl-CoA
name: 3-Hydroxyoctanoyl-CoA ↔ (2E)-Octenoyl-CoA + Water
conversion direction: REVERSIBLE

3-Oxotetradecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11966197
xref: Reference/HMDB HMDB0003935
xref: Reference/ChemSpider 10140190
xref: Reference/KEGG Compound C05261
xref: Reference/ChEBI CHEBI 28726
xref: Reference/CAS 122364-86-7
chemical formula: C35H60N7O18P3S
molecular weight: 991.29285
structure: ChemicalStructure/PW C001999

Reaction109635
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002008 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002006 Mitochondrial Matrix/Stoichiometry/1.0
right: Water
right: (2E)-Hexenoyl-CoA
spontaneous: false
left: 3-Hydroxyhexanoyl-CoA
name: 3-Hydroxyhexanoyl-CoA ↔ (2E)-Hexenoyl-CoA + Water
conversion direction: REVERSIBLE

Reaction109636
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000904 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001345 Mitochondrial Matrix/Stoichiometry/1.0
right: Crotonoyl-CoA
right: Water
spontaneous: false
left: 3-Hydroxybutyryl-CoA
name: 3-Hydroxybutyryl-CoA ↔ Crotonoyl-CoA + Water
conversion direction: REVERSIBLE

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/CAS 2871-66-1
type: UnificationXref
id: 2871-66-1
db: CAS

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Reference/CAS 35106-50-4
type: UnificationXref
id: 35106-50-4
db: CAS

Reaction109640
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001999 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001998 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-Oxotetradecanoyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
left: 3-Hydroxytetradecanoyl-CoA
left: NAD
name: 3-Hydroxytetradecanoyl-CoA + NAD ↔ 3-Oxotetradecanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Protein/7725 Mitochondrial Outer Membrane/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

Palmitic acid
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Palmitic acid

Short-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/13906 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/PubChem-compound 16061159
type: UnificationXref
id: 16061159
db: PubChem-compound

Compound/PW C002002 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxydecanoyl-CoA
stoichiometric coefficient: 1.0

Reaction109643
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002001 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002000 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-Oxododecanoyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
left: 3-Hydroxydodecanoyl-CoA
left: NAD
name: 3-Hydroxydodecanoyl-CoA + NAD ↔ 3-Oxododecanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reaction109645
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002003 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002002 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-Oxodecanoyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
left: NAD
left: 3-Hydroxydecanoyl-CoA
name: 3-Hydroxydecanoyl-CoA + NAD ↔ 3-Oxodecanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reaction109646
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002004 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002005 Mitochondrial Matrix/Stoichiometry/1.0
right: NADH
right: 3-Oxooctanoyl-CoA
right: Hydrogen Ion
spontaneous: false
left: 3-Hydroxyoctanoyl-CoA
left: NAD
name: 3-Hydroxyoctanoyl-CoA + NAD ↔ 3-Oxooctanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/BioCyc CPD-12174
type: UnificationXref
id: CPD-12174
db: BioCyc

Acetyl-CoA acetyltransferase, mitochondrial
type: Complex
cellular location: Mitochondrial Matrix

Reaction109648
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002007 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002006 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-Oxohexanoyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
left: 3-Hydroxyhexanoyl-CoA
left: NAD
name: 3-Hydroxyhexanoyl-CoA + NAD ↔ 3-Oxohexanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

ChemicalStructure/PW C002003
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002004
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002005
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001032
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001031
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C02593
type: UnificationXref
id: C02593
db: KEGG Compound

ChemicalStructure/PW C002006
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C03561
type: UnificationXref
id: C03561
db: KEGG Compound

3-Oxohexadecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 34619-89-1
xref: Reference/HMDB HMDB0006402
xref: Reference/ChEBI CHEBI 15491
xref: Reference/ChemSpider 389499
xref: Reference/PubChem-compound 440601
xref: Reference/KEGG Compound C05259
xref: Reference/BioCyc 3-OXOPALMITOYL-COA
chemical formula: C37H64N7O18P3S
molecular weight: 1019.32416
structure: ChemicalStructure/PW C002740

ChemicalStructure/PW C002000
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002001
type: ChemicalStructure
structure format: SMILES

Compound/PW C002003 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxodecanoyl-CoA
stoichiometric coefficient: 1.0

3-Hydroxyoctanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxyoctanoyl-CoA

Decanoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05274
xref: Reference/CAS 1264-57-9
xref: Reference/HMDB HMDB0006404
xref: Reference/PubChem-compound 440615
xref: Reference/ChEBI CHEBI 28493
xref: Reference/ChemSpider 389510
chemical formula: C31H54N7O17P3S
molecular weight: 921.251
structure: ChemicalStructure/PW C002742

ChemicalStructure/PW C002002
type: ChemicalStructure
structure format: SMILES

Reaction109651
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000904 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
left: 3-Hydroxybutyryl-CoA
left: NAD
name: 3-Hydroxybutyryl-CoA + NAD ↔ Acetoacetyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Protein/13903 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

1.3.8.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002009 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002009 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
right: (2E)-Hexadecenoyl-CoA
right: Reduced electron-transfer flavoprotein
spontaneous: false
EC number: 1.3.8.9
left: electron-transfer flavoprotein
left: Palmityl-CoA
name: Palmityl-CoA + electron-transfer flavoprotein → (2E)-Hexadecenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

Protein/13909 Mitochondrial Matrix/Stoichiometry/6.0
type: Stoichiometry
physical entity: Enoyl-CoA hydratase, mitochondrial
stoichiometric coefficient: 6.0

Reaction109618
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001171 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002010 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
right: Reduced electron-transfer flavoprotein
right: (2E)-Tetradecenoyl-CoA
spontaneous: false
left: Tetradecanoyl-CoA
left: electron-transfer flavoprotein
name: Tetradecanoyl-CoA + electron-transfer flavoprotein → (2E)-Tetradecenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

Reaction109619
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001928 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002010 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
right: Reduced electron-transfer flavoprotein
right: (2E)-Tetradecenoyl-CoA
spontaneous: false
left: Lauroyl-CoA
left: electron-transfer flavoprotein
name: Lauroyl-CoA + electron-transfer flavoprotein → (2E)-Tetradecenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

Compound/PW C000147 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Palmitoylcarnitine
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 54684-64-9
type: UnificationXref
id: 54684-64-9
db: CAS

Reference/BioCyc 3-OXOPALMITOYL-COA
type: UnificationXref
id: 3-OXOPALMITOYL-COA
db: BioCyc

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/UniProt Q07417
type: UnificationXref
id: Q07417
db: UniProt

Reference/CAS 2140-48-9
type: UnificationXref
id: 2140-48-9
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Compound/PW C000904 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxybutyryl-CoA
stoichiometric coefficient: 1.0

Compound/PW C002013 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Octenoyl-CoA
stoichiometric coefficient: 1.0

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetoacetyl-CoA

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/CAS 57-10-3
type: UnificationXref
id: 57-10-3
db: CAS

3-Oxooctanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Oxooctanoyl-CoA

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

1.3.8.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001032 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001345 Mitochondrial Matrix/Stoichiometry/1.0
right: Crotonoyl-CoA
right: Carbon dioxide
spontaneous: false
EC number: 1.3.8.6
left: Glutaryl-CoA
name: Glutaryl-CoA → Carbon dioxide + Crotonoyl-CoA
conversion direction: LEFT_TO_RIGHT

Reaction109628
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002009 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001996 Mitochondrial Matrix/Stoichiometry/1.0
right: (2E)-Hexadecenoyl-CoA
right: Water
spontaneous: false
left: 3-Hydroxyhexadecanoyl-CoA
name: 3-Hydroxyhexadecanoyl-CoA ↔ (2E)-Hexadecenoyl-CoA + Water
conversion direction: REVERSIBLE

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reaction109620
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002742 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002012 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
right: (2E)-Decenoyl-CoA
right: Reduced electron-transfer flavoprotein
spontaneous: false
left: electron-transfer flavoprotein
left: Decanoyl-CoA
name: Decanoyl-CoA + electron-transfer flavoprotein → (2E)-Decenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

Reaction109622
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000845 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002013 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
right: Reduced electron-transfer flavoprotein
right: (2E)-Octenoyl-CoA
spontaneous: false
left: Octanoyl-CoA
left: electron-transfer flavoprotein
name: Octanoyl-CoA + electron-transfer flavoprotein → (2E)-Octenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

1.3.8.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002008 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001719 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
right: Reduced electron-transfer flavoprotein
right: (2E)-Hexenoyl-CoA
spontaneous: false
EC number: 1.3.8.8
left: Hexanoyl-CoA
left: electron-transfer flavoprotein
name: Hexanoyl-CoA + electron-transfer flavoprotein → (2E)-Hexenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 165436
type: UnificationXref
id: 165436
db: PubChem-compound

1.3.8.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000856 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001345 Mitochondrial Matrix/Stoichiometry/1.0
right: Crotonoyl-CoA
right: Reduced electron-transfer flavoprotein
spontaneous: false
EC number: 1.3.8.8
left: electron-transfer flavoprotein
left: Butyryl-CoA
name: Butyryl-CoA + electron-transfer flavoprotein ↔ Crotonoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: REVERSIBLE

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

6.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000145 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Adenosine monophosphate
right: Palmityl-CoA
right: Pyrophosphate
spontaneous: false
EC number: 6.2.1.3
left: Coenzyme A
left: Palmitic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Coenzyme A + Palmitic acid → Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000044
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)C[C@H](O)CC([O-])=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Compound/PW C000044 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Glutaryl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q60759
organism: Mus musculus

Enoyl-CoA hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8BH95
organism: Mus musculus

Short-chain specific acyl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q07417
organism: Mus musculus

Long-chain-fatty-acid--CoA ligase 1
type: ProteinReference
xref: Reference/UniProt P41216
organism: Mus musculus

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9DBL1
organism: Mus musculus

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine triphosphate

Long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P51174
organism: Mus musculus

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P45952
organism: Mus musculus

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P50544
organism: Mus musculus

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt Q8BH95
type: UnificationXref
id: Q8BH95
db: UniProt

Reference/BioCyc GLUTARYL-COA
type: UnificationXref
id: GLUTARYL-COA
db: BioCyc

Long-chain-fatty-acid--CoA ligase 1
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Long-chain-fatty-acid--CoA ligase 1

(2E)-Hexenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Hexenoyl-CoA

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Glutaryl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutaryl-CoA dehydrogenase, mitochondrial

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Compound/PW C001928 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lauroyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Protein/7725 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/CAS 6245-70-1
type: UnificationXref
id: 6245-70-1
db: CAS

Compound/PW C001099 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Glutaryl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/13908 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Glutaryl-CoA dehydrogenase, mitochondrial

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C002001 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxododecanoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C002000 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxydodecanoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C001345 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Crotonoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C002009 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Hexadecenoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 960
type: UnificationXref
id: 960
db: ChemSpider

Reference/HMDB HMDB0002009
type: UnificationXref
id: HMDB0002009
db: HMDB

Protein/13902 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Compound/PW C002008 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Hexenoyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt P50544
type: UnificationXref
id: P50544
db: UniProt

Protein/13905 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0003571
type: UnificationXref
id: HMDB0003571
db: HMDB

Reference/HMDB HMDB0000062
type: UnificationXref
id: HMDB0000062
db: HMDB

Compound/PW C002004 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxyoctanoyl-CoA
stoichiometric coefficient: 1.0

Protein/13906 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Compound/PW C002005 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxooctanoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 1264-52-4
type: UnificationXref
id: 1264-52-4
db: CAS

Reference/PubChem-compound 985
type: UnificationXref
id: 985
db: PubChem-compound

Transport1038
type: Transport
participant stoichiometry: Compound/PW C000147 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000147 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Palmitoylcarnitine
spontaneous: false
left: L-Palmitoylcarnitine
name: L-Palmitoylcarnitine (→) Transport: Mus musculus, Cell, Cytoplasm to Mus musculus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

3-Oxododecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Oxododecanoyl-CoA

ChemicalStructure/PW C002007
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002008
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002009
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

ChemicalStructure/PW C002010
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C002012
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002013
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/HMDB HMDB0001166
type: UnificationXref
id: HMDB0001166
db: HMDB

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

ReactionCatalysis99917
type: Catalysis
controller: Acetyl-CoA acetyltransferase, mitochondrial
controlled: Reaction109658
control type: ACTIVATION

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/UniProt P52825
type: UnificationXref
id: P52825
db: UniProt

Protein/13910 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Trifunctional enzyme subunit alpha, mitochondrial
stoichiometric coefficient: 4.0

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/PubChem-compound 11953816
type: UnificationXref
id: 11953816
db: PubChem-compound

Reference/UniProt Q9DBL1
type: UnificationXref
id: Q9DBL1
db: UniProt

ChemicalStructure/PW C001171
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 65113
type: UnificationXref
id: 65113
db: PubChem-compound

3-Hydroxytetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxytetradecanoyl-CoA

L-Palmitoylcarnitine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000222
xref: Reference/CAS 2364-67-2
xref: Reference/PubChem-compound 11953816
xref: Reference/ChEBI CHEBI 17490
xref: Reference/ChemSpider 10128117
xref: Reference/KEGG Compound C02990
xref: Reference/BioCyc CPD-419
chemical formula: C23H45NO4
molecular weight: 399.33487
structure: ChemicalStructure/PW C000147

Reference/CAS 78303-19-2
type: UnificationXref
id: 78303-19-2
db: CAS

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Compound/PW C002010 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Tetradecenoyl-CoA
stoichiometric coefficient: 1.0

3-Oxotetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Oxotetradecanoyl-CoA

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Coenzyme A

Reference/ChemSpider 10140190
type: UnificationXref
id: 10140190
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Palmityl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Palmityl-CoA

Reference/ChemSpider 371
type: UnificationXref
id: 371
db: ChemSpider

Glycerolipid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway107912
pathway component: SubPathwayInteraction107912
xref: Reference/PathWhiz PW000144
xref: Reference/SMPDB SMP0000039
name: SubPathway

Reference/BioCyc CPD-419
type: UnificationXref
id: CPD-419
db: BioCyc

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 57371
type: UnificationXref
id: CHEBI:57371
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PathWhiz PW088254
type: UnificationXref
id: PW088254
db: PathWhiz

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/HMDB HMDB0003934
type: UnificationXref
id: HMDB0003934
db: HMDB

Reference/HMDB HMDB0002845
type: UnificationXref
id: HMDB0002845
db: HMDB

Reference/HMDB HMDB0003935
type: UnificationXref
id: HMDB0003935
db: HMDB

Reference/HMDB HMDB0003932
type: UnificationXref
id: HMDB0003932
db: HMDB

Reference/CAS 5060-32-2
type: UnificationXref
id: 5060-32-2
db: CAS

3-Hydroxyhexadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxyhexadecanoyl-CoA

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Compound/Generic70 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced electron-transfer flavoprotein
stoichiometric coefficient: 1.0

L-Carnitine
type: SmallMoleculeReference
xref: Reference/BioCyc CARNITINE
xref: Reference/ChEBI CHEBI 16347
xref: Reference/PubChem-compound 10917
xref: Reference/CAS 541-15-1
xref: Reference/KEGG Compound C00318
xref: Reference/HMDB HMDB0000062
xref: Reference/ChemSpider 10455
chemical formula: C7H15NO3
molecular weight: 161.1052
structure: ChemicalStructure/PW C000044

Reference/CAS 102680-35-3
type: UnificationXref
id: 102680-35-3
db: CAS

Compound/PW C002006 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxyhexanoyl-CoA
stoichiometric coefficient: 1.0

Trifunctional Protein Deficiency
type: Pathway
pathway order: PathwayEnzymeReaction/2110881
pathway order: PathwayEnzymeReaction/2110880
pathway order: PathwayEnzymeReaction/2110861
pathway order: PathwayEnzymeReaction/2110883
pathway order: PathwayEnzymeReaction/2110860
pathway order: PathwayEnzymeReaction/2110882
pathway order: PathwayEnzymeReaction/2110863
pathway order: PathwayEnzymeReaction/2110885
pathway order: PathwayEnzymeReaction/2110862
pathway order: PathwayEnzymeReaction/2110884
pathway order: PathwayEnzymeReaction/2110843
pathway order: PathwayEnzymeReaction/2110865
pathway order: PathwayEnzymeReaction/2110864
pathway order: PathwayEnzymeReaction/2110845
pathway order: PathwayEnzymeReaction/2110867
pathway order: PathwayEnzymeReaction/2110844
pathway order: PathwayEnzymeReaction/2110866
pathway order: PathwayTransport/2110886
pathway order: PathwayEnzymeReaction/2110847
pathway order: PathwayEnzymeReaction/2110869
pathway order: PathwayEnzymeReaction/2110846
pathway order: PathwayEnzymeReaction/2110868
pathway order: PathwayEnzymeReaction/2110859
pathway order: PathwaySubPathway/107913
pathway order: PathwayEnzymeReaction/2110870
pathway order: PathwayEnzymeReaction/2110850
pathway order: PathwayEnzymeReaction/2110872
pathway order: PathwayEnzymeReaction/2110871
pathway order: PathwayEnzymeReaction/2110852
pathway order: PathwayEnzymeReaction/2110874
pathway order: PathwayEnzymeReaction/2110851
pathway order: PathwayEnzymeReaction/2110873
pathway order: PathwayEnzymeReaction/2110854
pathway order: PathwayEnzymeReaction/2110876
pathway order: PathwaySubPathway/107911
pathway order: PathwayEnzymeReaction/2110853
pathway order: PathwayEnzymeReaction/2110875
pathway order: PathwaySubPathway/107912
pathway order: PathwayEnzymeReaction/2110856
pathway order: PathwayEnzymeReaction/2110878
pathway order: PathwayEnzymeReaction/2110855
pathway order: PathwayEnzymeReaction/2110877
pathway order: PathwayEnzymeReaction/2110858
pathway order: PathwayEnzymeReaction/2110857
pathway order: PathwayEnzymeReaction/2110879
pathway order: PathwayEnzymeReaction/2110849
pathway order: PathwayEnzymeReaction/2110848
pathway component: Reaction109638
pathway component: ReactionCatalysis99849
pathway component: Reaction109630
pathway component: ReactionCatalysis99847
pathway component: Reaction109631
pathway component: Reaction109632
pathway component: ReactionCatalysis99845
pathway component: Reaction109633
pathway component: ReactionCatalysis99846
pathway component: ReactionCatalysis99843
pathway component: ReactionCatalysis99888
pathway component: Reaction109635
pathway component: ReactionCatalysis99844
pathway component: Reaction109636
pathway component: ReactionCatalysis99842
pathway component: ReactionCatalysis99850
pathway component: ReactionCatalysis99851
pathway component: ReactionCatalysis99895
pathway component: 2.3.1.21
pathway component: 2.3.1.16
pathway component: ReactionCatalysis99891
pathway component: Reaction109640
pathway component: Glycerolipid Metabolism
pathway component: Reaction109643
pathway component: ReactionCatalysis99856
pathway component: ReactionCatalysis99857
pathway component: Reaction109645

Reference/BioCyc PALMITYL-COA
type: UnificationXref
id: PALMITYL-COA
db: BioCyc

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/PubChem-compound 440608
type: UnificationXref
id: 440608
db: PubChem-compound

Compound/PW C001171 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetradecanoyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001999
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003938
type: UnificationXref
id: HMDB0003938
db: HMDB

Reference/PubChem-compound 440606
type: UnificationXref
id: 440606
db: PubChem-compound

ChemicalStructure/PW C001998
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003939
type: UnificationXref
id: HMDB0003939
db: HMDB

Reference/HMDB HMDB0003936
type: UnificationXref
id: HMDB0003936
db: HMDB

Reference/PubChem-compound 440604
type: UnificationXref
id: 440604
db: PubChem-compound

Reference/PubChem-compound 380
type: UnificationXref
id: 380
db: PubChem-compound

Reference/PubChem-compound 5280381
type: UnificationXref
id: 5280381
db: PubChem-compound

ChemicalStructure/PW C001996
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/PubChem-compound 440603
type: UnificationXref
id: 440603
db: PubChem-compound

Reference/HMDB HMDB0003937
type: UnificationXref
id: HMDB0003937
db: HMDB

Reference/PubChem-compound 440602
type: UnificationXref
id: 440602
db: PubChem-compound

Reference/PubChem-compound 265
type: UnificationXref
id: 265
db: PubChem-compound

Reference/PubChem-compound 440601
type: UnificationXref
id: 440601
db: PubChem-compound

Reference/PubChem-compound 440600
type: UnificationXref
id: 440600
db: PubChem-compound

Reference/HMDB HMDB0003941
type: UnificationXref
id: HMDB0003941
db: HMDB

Reference/HMDB HMDB0003942
type: UnificationXref
id: HMDB0003942
db: HMDB

Fatty Acid Elongation in Mitochondria
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway107911
pathway component: SubPathwayInteraction107911
xref: Reference/PathWhiz PW000022
xref: Reference/SMPDB SMP0000054
name: SubPathway

Reference/HMDB HMDB0001521
type: UnificationXref
id: HMDB0001521
db: HMDB

Reference/HMDB HMDB0003940
type: UnificationXref
id: HMDB0003940
db: HMDB

Reference/HMDB HMDB0003945
type: UnificationXref
id: HMDB0003945
db: HMDB

Reference/HMDB HMDB0003946
type: UnificationXref
id: HMDB0003946
db: HMDB

Reference/HMDB HMDB0003943
type: UnificationXref
id: HMDB0003943
db: HMDB

Reference/HMDB HMDB0003944
type: UnificationXref
id: HMDB0003944
db: HMDB

Crotonoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00877
xref: Reference/HMDB HMDB0002009
xref: Reference/PubChem-compound 5280381
xref: Reference/CAS 102680-35-3
xref: Reference/BioCyc CPD-1083
xref: Reference/ChEBI CHEBI 15473
xref: Reference/ChemSpider 4444072
chemical formula: C25H40N7O17P3S
molecular weight: 835.1414
structure: ChemicalStructure/PW C001345

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Butyryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Butyryl-CoA

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/BioCyc K-HEXANOYL-COA
type: UnificationXref
id: K-HEXANOYL-COA
db: BioCyc

Reference/HMDB HMDB0003949
type: UnificationXref
id: HMDB0003949
db: HMDB

Reference/HMDB HMDB0003948
type: UnificationXref
id: HMDB0003948
db: HMDB

ChemicalStructure/PW C002740
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002742
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Coenzyme A

Reference/ChEBI CHEBI 61526
type: UnificationXref
id: CHEBI:61526
db: ChEBI

Palmitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 985
xref: Reference/KEGG Compound C00249
xref: Reference/ChemSpider 960
xref: Reference/ChEBI CHEBI 15756
xref: Reference/BioCyc CPD-8475
xref: Reference/CAS 57-10-3
xref: Reference/HMDB HMDB0000220
chemical formula: C16H32O2
molecular weight: 256.24023
structure: ChemicalStructure/PW C000145

Reference/ChemSpider 260
type: UnificationXref
id: 260
db: ChemSpider

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

Compound/PW C001031 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmityl-CoA
stoichiometric coefficient: 1.0

Enoyl-CoA hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/13909 Mitochondrial Matrix/Stoichiometry/6.0
cellular location: Mitochondrial Matrix
component: Enoyl-CoA hydratase, mitochondrial

Reference/ChEBI CHEBI 15521
type: UnificationXref
id: CHEBI:15521
db: ChEBI

Reference/ChEBI CHEBI 15524
type: UnificationXref
id: CHEBI:15524
db: ChEBI

Reference/ChEBI CHEBI 15525
type: UnificationXref
id: CHEBI:15525
db: ChEBI

Reference/CAS 541-15-1
type: UnificationXref
id: 541-15-1
db: CAS

3-Hydroxyhexanoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003942
xref: Reference/CAS 79171-47-4
xref: Reference/KEGG Compound C05268
xref: Reference/PubChem-compound 11966160
xref: Reference/ChEBI CHEBI 28276
xref: Reference/ChemSpider 10140154
chemical formula: C27H46N7O18P3S
molecular weight: 881.1833
structure: ChemicalStructure/PW C002006

3-Oxohexanoyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc K-HEXANOYL-COA
xref: Reference/HMDB HMDB0003943
xref: Reference/ChEBI CHEBI 27648
xref: Reference/ChemSpider 389508
xref: Reference/CAS 19774-86-8
xref: Reference/KEGG Compound C05269
xref: Reference/PubChem-compound 440610
chemical formula: C27H44N7O18P3S
molecular weight: 879.16766
structure: ChemicalStructure/PW C002007

(2E)-Hexenoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280765
xref: Reference/KEGG Compound C05271
xref: Reference/ChemSpider 4444331
xref: Reference/HMDB HMDB0003944
xref: Reference/ChEBI CHEBI 28706
xref: Reference/CAS 10018-93-6
chemical formula: C27H44N7O17P3S
molecular weight: 863.1727
structure: ChemicalStructure/PW C002008

(2E)-Hexadecenoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003945
xref: Reference/ChEBI CHEBI 61526
xref: Reference/KEGG Compound C05272
xref: Reference/PubChem-compound 46173176
xref: Reference/ChemSpider 26332261
xref: Reference/CAS 4460-95-1
chemical formula: C37H64N7O17P3S
molecular weight: 1003.3292
structure: ChemicalStructure/PW C002009

Compound/PW C002012 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Decenoyl-CoA
stoichiometric coefficient: 1.0

Palmityl-CoA
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Palmityl-CoA

Reference/ChemSpider 4444072
type: UnificationXref
id: 4444072
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

(2E)-Tetradecenoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444333
xref: Reference/ChEBI CHEBI 27721
xref: Reference/HMDB HMDB0003946
xref: Reference/CAS 38795-33-4
xref: Reference/KEGG Compound C05273
xref: Reference/PubChem-compound 5280767
chemical formula: C35H60N7O17P3S
molecular weight: 975.2979
structure: ChemicalStructure/PW C002010

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

(2E)-Decenoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05275
xref: Reference/BioCyc T2-DECENOYL-COA
xref: Reference/ChemSpider 4444334
xref: Reference/ChEBI CHEBI 10723
xref: Reference/CAS 10018-95-8
xref: Reference/HMDB HMDB0003948
xref: Reference/PubChem-compound 5280768
chemical formula: C31H52N7O17P3S
molecular weight: 919.23535
structure: ChemicalStructure/PW C002012

(2E)-Octenoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444335
xref: Reference/KEGG Compound C05276
xref: Reference/ChEBI CHEBI 27537
xref: Reference/HMDB HMDB0003949
xref: Reference/PubChem-compound 5280769
xref: Reference/CAS 10018-94-7
chemical formula: C29H48N7O17P3S
molecular weight: 891.20404
structure: ChemicalStructure/PW C002013

ChemicalStructure/PW C001345
type: ChemicalStructure
structure format: SMILES

Carnitine O-palmitoyltransferase 1
type: Complex
component stoichiometry: Protein/7725 Mitochondrial Outer Membrane/Stoichiometry/6.0
cellular location: Mitochondrial Outer Membrane
component: Unknown

Reference/ChEBI CHEBI 28726
type: UnificationXref
id: CHEBI:28726
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Pyrophosphate

Compound/Generic69 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: electron-transfer flavoprotein
stoichiometric coefficient: 1.0

Reference/ChemSpider 10140154
type: UnificationXref
id: 10140154
db: ChemSpider

Long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/13902 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 15533
type: UnificationXref
id: CHEBI:15533
db: ChEBI

Reference/ChEBI CHEBI 15532
type: UnificationXref
id: CHEBI:15532
db: ChEBI

Compound/PW C000044 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

(2E)-Hexadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: (2E)-Hexadecenoyl-CoA

3-Oxohexanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Oxohexanoyl-CoA

Compound/PW C002009 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Hexadecenoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28706
type: UnificationXref
id: CHEBI:28706
db: ChEBI

Reference/PubChem-compound 440615
type: UnificationXref
id: 440615
db: PubChem-compound

Reference/CAS 1763-10-6
type: UnificationXref
id: 1763-10-6
db: CAS

Reference/BioCyc TETRADECANOYL-COA
type: UnificationXref
id: TETRADECANOYL-COA
db: BioCyc

Reference/BioCyc CPD-1083
type: UnificationXref
id: CPD-1083
db: BioCyc

Reference/KEGG Compound C05259
type: UnificationXref
id: C05259
db: KEGG Compound

Reference/KEGG Compound C05258
type: UnificationXref
id: C05258
db: KEGG Compound

Reference/PubChem-compound 440610
type: UnificationXref
id: 440610
db: PubChem-compound

Reference/HMDB HMDB0000222
type: UnificationXref
id: HMDB0000222
db: HMDB

Enoyl-CoA hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Enoyl-CoA hydratase, mitochondrial

Reference/KEGG Compound C05264
type: UnificationXref
id: C05264
db: KEGG Compound

Reference/KEGG Compound C05263
type: UnificationXref
id: C05263
db: KEGG Compound

Reference/KEGG Compound C05266
type: UnificationXref
id: C05266
db: KEGG Compound

Reference/KEGG Compound C05265
type: UnificationXref
id: C05265
db: KEGG Compound

ChemicalStructure/PW C000147
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

Reference/KEGG Compound C05260
type: UnificationXref
id: C05260
db: KEGG Compound

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Octanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Octanoyl-CoA

ChemicalStructure/PW C000145
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(O)=O

Reference/KEGG Compound C05262
type: UnificationXref
id: C05262
db: KEGG Compound

Reference/KEGG Compound C05261
type: UnificationXref
id: C05261
db: KEGG Compound

Reference/ChEBI CHEBI 27868
type: UnificationXref
id: CHEBI:27868
db: ChEBI

Reference/CAS 19774-86-8
type: UnificationXref
id: 19774-86-8
db: CAS

Reference/SMPDB SMP0000054
type: UnificationXref
id: SMP0000054
db: SMPDB

Tetradecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 3130-72-1
xref: Reference/HMDB HMDB0001521
xref: Reference/KEGG Compound C02593
xref: Reference/ChEBI CHEBI 15532
xref: Reference/ChemSpider 58623
xref: Reference/PubChem-compound 65113
xref: Reference/BioCyc TETRADECANOYL-COA
chemical formula: C35H62N7O17P3S
molecular weight: 977.3136
structure: ChemicalStructure/PW C001171

Reference/HMDB HMDB0000220
type: UnificationXref
id: HMDB0000220
db: HMDB

electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: electron-transfer flavoprotein

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C05268
type: UnificationXref
id: C05268
db: KEGG Compound

Reference/KEGG Compound C05267
type: UnificationXref
id: C05267
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Reference/KEGG Compound C05269
type: UnificationXref
id: C05269
db: KEGG Compound

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05275
type: UnificationXref
id: C05275
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/KEGG Compound C05274
type: UnificationXref
id: C05274
db: KEGG Compound

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

Reference/KEGG Compound C05276
type: UnificationXref
id: C05276
db: KEGG Compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/KEGG Compound C05271
type: UnificationXref
id: C05271
db: KEGG Compound

Reference/KEGG Compound C05270
type: UnificationXref
id: C05270
db: KEGG Compound

Reference/KEGG Compound C05273
type: UnificationXref
id: C05273
db: KEGG Compound

Reference/KEGG Compound C05272
type: UnificationXref
id: C05272
db: KEGG Compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Decanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Decanoyl-CoA

Compound/PW C001999 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxotetradecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 34619-89-1
type: UnificationXref
id: 34619-89-1
db: CAS

Compound/PW C001998 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxytetradecanoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C001996 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxyhexadecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15756
type: UnificationXref
id: CHEBI:15756
db: ChEBI

Palmityl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Palmityl-CoA

L-Palmitoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Palmitoylcarnitine

(2E)-Hexadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Hexadecenoyl-CoA

Palmityl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 15667
xref: Reference/ChemSpider 14902
xref: Reference/HMDB HMDB0001338
xref: Reference/ChEBI CHEBI 15525
xref: Reference/KEGG Compound C00154
xref: Reference/CAS 1763-10-6
xref: Reference/BioCyc PALMITYL-COA
chemical formula: C37H66N7O17P3S
molecular weight: 1005.34485
structure: ChemicalStructure/PW C001031

3-Hydroxydodecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 72059-49-5
xref: Reference/ChemSpider 389501
xref: Reference/ChEBI CHEBI 27668
xref: Reference/KEGG Compound C05262
xref: Reference/HMDB HMDB0003936
xref: Reference/PubChem-compound 440603
chemical formula: C33H58N7O18P3S
molecular weight: 965.27716
structure: ChemicalStructure/PW C002000

Glutaryl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc GLUTARYL-COA
xref: Reference/CAS 103192-48-9
xref: Reference/ChEBI CHEBI 15524
xref: Reference/PubChem-compound 439252
xref: Reference/HMDB HMDB0001339
xref: Reference/KEGG Compound C00527
xref: Reference/ChemSpider 388388
chemical formula: C26H42N7O19P3S
molecular weight: 881.1469
structure: ChemicalStructure/PW C001032

Reference/ChEBI CHEBI 27721
type: UnificationXref
id: CHEBI:27721
db: ChEBI

3-Oxododecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05263
xref: Reference/ChemSpider 389502
xref: Reference/CAS 78303-19-2
xref: Reference/ChEBI CHEBI 27868
xref: Reference/PubChem-compound 440604
xref: Reference/HMDB HMDB0003937
chemical formula: C33H56N7O18P3S
molecular weight: 963.26154
structure: ChemicalStructure/PW C002001

3-Hydroxydecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05264
xref: Reference/ChEBI CHEBI 28325
xref: Reference/CAS 6245-70-1
xref: Reference/ChemSpider 17220838
xref: Reference/HMDB HMDB0003938
xref: Reference/PubChem-compound 16061159
chemical formula: C31H54N7O18P3S
molecular weight: 937.2459
structure: ChemicalStructure/PW C002002

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

3-Oxodecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05265
xref: Reference/ChEBI CHEBI 28528
xref: Reference/ChemSpider 389504
xref: Reference/PubChem-compound 440606
xref: Reference/HMDB HMDB0003939
xref: Reference/CAS 50411-91-1
chemical formula: C31H52N7O18P3S
molecular weight: 935.2302
structure: ChemicalStructure/PW C002003

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

3-Hydroxyoctanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28632
xref: Reference/KEGG Compound C05266
xref: Reference/HMDB HMDB0003940
xref: Reference/CAS 79171-48-5
xref: Reference/PubChem-compound 53477508
chemical formula: C29H50N7O18P3S
molecular weight: 909.2146
structure: ChemicalStructure/PW C002004

Reference/HMDB HMDB0001339
type: UnificationXref
id: HMDB0001339
db: HMDB

Reference/HMDB HMDB0001338
type: UnificationXref
id: HMDB0001338
db: HMDB

3-Oxooctanoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003941
xref: Reference/ChemSpider 389506
xref: Reference/PubChem-compound 440608
xref: Reference/BioCyc 7-METHYL-3-OXOOCTANOYL-COA
xref: Reference/ChEBI CHEBI 28264
xref: Reference/KEGG Compound C05267
xref: Reference/CAS 54684-64-9
chemical formula: C29H48N7O18P3S
molecular weight: 907.1989
structure: ChemicalStructure/PW C002005

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Reference/ChemSpider 58623
type: UnificationXref
id: 58623
db: ChemSpider

Reference/CAS 10018-95-8
type: UnificationXref
id: 10018-95-8
db: CAS

Reference/CAS 79171-47-4
type: UnificationXref
id: 79171-47-4
db: CAS

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

electron-transfer flavoprotein
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 5086

3-Oxodecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Oxodecanoyl-CoA

ReactionCatalysis99888
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction109645
control type: ACTIVATION

Compound/PW C001031 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmityl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Unknown
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Unknown

ChemicalStructure/PW C000845
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
type: UnificationXref
id: 2-METHYL-3-HYDROXY-BUTYRYL-COA
db: BioCyc

Reference/PubChem-compound 5280765
type: UnificationXref
id: 5280765
db: PubChem-compound

Reduced electron-transfer flavoprotein
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 5086

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

ReactionCatalysis99895
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction109648
control type: ACTIVATION

Carnitine O-palmitoyltransferase 2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Carnitine O-palmitoyltransferase 2, mitochondrial

ReactionCatalysis99891
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction109646
control type: ACTIVATION

Reference/ChEBI CHEBI 28528
type: UnificationXref
id: CHEBI:28528
db: ChEBI

Reference/SMPDB SMP0087235
type: UnificationXref
id: SMP0087235
db: SMPDB

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/PubChem-compound 5280769
type: UnificationXref
id: 5280769
db: PubChem-compound

Reference/CAS 50411-91-1
type: UnificationXref
id: 50411-91-1
db: CAS

Reference/PubChem-compound 5280767
type: UnificationXref
id: 5280767
db: PubChem-compound

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/PubChem-compound 5280768
type: UnificationXref
id: 5280768
db: PubChem-compound

Reference/ChemSpider 395736
type: UnificationXref
id: 395736
db: ChemSpider

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/BioCyc CPD-8475
type: UnificationXref
id: CPD-8475
db: BioCyc

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

ReactionCatalysis99899
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction109651
control type: ACTIVATION

Reference/ChEBI CHEBI 15452
type: UnificationXref
id: CHEBI:15452
db: ChEBI

Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000856
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 389056
type: UnificationXref
id: 389056
db: ChemSpider

Reference/ChEBI CHEBI 28632
type: UnificationXref
id: CHEBI:28632
db: ChEBI

Reference/PubChem-compound 10917
type: UnificationXref
id: 10917
db: PubChem-compound

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/ChEBI CHEBI 27668
type: UnificationXref
id: CHEBI:27668
db: ChEBI

Compound/PW C001031 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmityl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 79171-48-5
type: UnificationXref
id: 79171-48-5
db: CAS

Reference/ChemSpider 10128117
type: UnificationXref
id: 10128117
db: ChemSpider

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

3-Hydroxybutyryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxybutyryl-CoA

Reference/ChemSpider 10455
type: UnificationXref
id: 10455
db: ChemSpider

Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27540
type: UnificationXref
id: CHEBI:27540
db: ChEBI

Reference/KEGG Compound C01944
type: UnificationXref
id: C01944
db: KEGG Compound

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Reference/ChemSpider 14902
type: UnificationXref
id: 14902
db: ChemSpider

Compound/PW C000845 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Octanoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Compound/PW C001032 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutaryl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Crotonoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Crotonoyl-CoA

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

3-Hydroxydodecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxydodecanoyl-CoA

Reference/ChEBI CHEBI 27537
type: UnificationXref
id: CHEBI:27537
db: ChEBI

Trifunctional enzyme subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Trifunctional enzyme subunit alpha, mitochondrial

ChemicalStructure/PW C001928
type: ChemicalStructure
structure format: SMILES

Palmitic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Palmitic acid
name: SubPathwayOutput
name: SubPathwayInput

Reference/KEGG Compound C01832
type: UnificationXref
id: C01832
db: KEGG Compound

Unknown
type: ProteinReference
organism: Mus musculus

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/SMPDB SMP0000039
type: UnificationXref
id: SMP0000039
db: SMPDB

Reference/PubChem-compound 449118
type: UnificationXref
id: 449118
db: PubChem-compound

Reference/CAS 122364-86-7
type: UnificationXref
id: 122364-86-7
db: CAS

Reference/ChEBI CHEBI 27402
type: UnificationXref
id: CHEBI:27402
db: ChEBI

Reference/ChEBI CHEBI 27648
type: UnificationXref
id: CHEBI:27648
db: ChEBI

3-Hydroxyhexanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxyhexanoyl-CoA

Compound/PW C000147 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Palmitoylcarnitine
stoichiometric coefficient: 1.0

Reference/BioCyc T2-DECENOYL-COA
type: UnificationXref
id: T2-DECENOYL-COA
db: BioCyc

Reference/KEGG Compound C00877
type: UnificationXref
id: C00877
db: KEGG Compound

Reference/PathWhiz PW000144
type: UnificationXref
id: PW000144
db: PathWhiz

Reference/PathWhiz PW000022
type: UnificationXref
id: PW000022
db: PathWhiz

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/ChemSpider 145018
type: UnificationXref
id: 145018
db: ChemSpider

Reference/CAS 10018-93-6
type: UnificationXref
id: 10018-93-6
db: CAS

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

3-Hydroxybutyryl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 2871-66-1
xref: Reference/KEGG Compound C03561
xref: Reference/PubChem-compound 440045
xref: Reference/HMDB HMDB0001166
xref: Reference/ChEBI CHEBI 15452
xref: Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
xref: Reference/ChemSpider 389056
chemical formula: C25H42N7O18P3S
molecular weight: 853.152
structure: ChemicalStructure/PW C000904

Reference/ChEBI CHEBI 28325
type: UnificationXref
id: CHEBI:28325
db: ChEBI

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 16347
type: UnificationXref
id: CHEBI:16347
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/KEGG Compound C00527
type: UnificationXref
id: C00527
db: KEGG Compound

Reference/UniProt Q8BMS1
type: UnificationXref
id: Q8BMS1
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15491
type: UnificationXref
id: CHEBI:15491
db: ChEBI

Reference/ChemSpider 389499
type: UnificationXref
id: 389499
db: ChemSpider

Reference/UniProt Q60759
type: UnificationXref
id: Q60759
db: UniProt

Reference/ChemSpider 389498
type: UnificationXref
id: 389498
db: ChemSpider

Reference/ChEBI CHEBI 27466
type: UnificationXref
id: CHEBI:27466
db: ChEBI

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChemSpider 26332261
type: UnificationXref
id: 26332261
db: ChemSpider

Reference/ChemSpider 4444333
type: UnificationXref
id: 4444333
db: ChemSpider

Compound/PW C002742 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Decanoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444334
type: UnificationXref
id: 4444334
db: ChemSpider

Compound/PW C002740 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxohexadecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444335
type: UnificationXref
id: 4444335
db: ChemSpider

ChemicalStructure/PW C001719
type: ChemicalStructure
structure format: SMILES

Unknown
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Unknown

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

(2E)-Tetradecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Tetradecenoyl-CoA

Short-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Glutaryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glutaryl-CoA

Reference/ChemSpider 4444331
type: UnificationXref
id: 4444331
db: ChemSpider

Reference/PubChem-compound 46173176
type: UnificationXref
id: 46173176
db: PubChem-compound

Reference/CAS 6244-92-4
type: UnificationXref
id: 6244-92-4
db: CAS

Reference/CAS 10018-94-7
type: UnificationXref
id: 10018-94-7
db: CAS

Compound/PW C000145 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439252
type: UnificationXref
id: 439252
db: PubChem-compound

Reference/SMPDB SMP0120609
type: UnificationXref
id: SMP0120609
db: SMPDB

Carnitine O-palmitoyltransferase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P52825
organism: Mus musculus

Reference/PubChem-compound 15667
type: UnificationXref
id: 15667
db: PubChem-compound

Compound/PW C000856 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Butyryl-CoA
stoichiometric coefficient: 1.0

SubPathwayInteraction107912
type: Interaction
name: SubPathway107912Reaction
name: SubPathwayReaction
participant: Palmitic acid

SubPathwayInteraction107913
type: Interaction
name: SubPathway107913Reaction
name: SubPathwayReaction
participant: Palmitic acid

L-Palmitoylcarnitine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Palmitoylcarnitine

SubPathwayInteraction107911
type: Interaction
name: SubPathwayReaction
name: SubPathway107911Reaction
participant: Palmitic acid

Trifunctional enzyme, mitochondrial
type: Complex
component stoichiometry: Protein/13910 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Trifunctional enzyme subunit alpha, mitochondrial

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: electron-transfer flavoprotein

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/ChemSpider 388388
type: UnificationXref
id: 388388
db: ChemSpider

Reference/ChEBI CHEBI 15473
type: UnificationXref
id: CHEBI:15473
db: ChEBI

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/UniProt P51174
type: UnificationXref
id: P51174
db: UniProt