Reference/UniProt P50172
type: UnificationXref
id: P50172
db: UniProt

Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C01089
type: UnificationXref
id: C01089
db: KEGG Compound

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Succinic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinic acid

Reference/KEGG Compound C00207
type: UnificationXref
id: C00207
db: KEGG Compound

Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000054
type: UnificationXref
id: PW000054
db: PathWhiz

Reference/PathWhiz PW000050
type: UnificationXref
id: PW000050
db: PathWhiz

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetyl-CoA
name: SubPathwayOutput
name: SubPathwayInput

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway107946
pathway component: SubPathwayInteraction107946
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Compound/PW C001212 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetone
stoichiometric coefficient: 1.0

Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Acetone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetone

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

(R)-3-Hydroxybutyric acid
type: SmallMoleculeReference
xref: Reference/CAS 625-72-9
xref: Reference/BioCyc CPD-335
xref: Reference/PubChem-compound 92135
xref: Reference/KEGG Compound C01089
xref: Reference/ChemSpider 83181
xref: Reference/HMDB HMDB0000011
xref: Reference/ChEBI CHEBI 17066
chemical formula: C4H8O3
molecular weight: 104.04734
structure: ChemicalStructure/PW C000006

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl-CoA
name: SubPathwayOutput

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/UniProt P38060
type: UnificationXref
id: P38060
db: UniProt

Fatty Acid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway107944
pathway component: SubPathwayInteraction107944
xref: Reference/SMPDB SMP0000051
xref: Reference/PathWhiz PW000023
name: SubPathway

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/CAS 67-64-1
type: UnificationXref
id: 67-64-1
db: CAS

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Hydroxymethylglutaryl-CoA synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P54869
organism: Mus musculus

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/SMPDB SMP0120633
type: UnificationXref
id: SMP0120633
db: SMPDB

Pyruvate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway107945
pathway component: SubPathwayInteraction107945
xref: Reference/SMPDB SMP0000060
xref: Reference/PathWhiz PW000054
name: SubPathway

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Protein/14117 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydroxymethylglutaryl-CoA lyase, mitochondrial
stoichiometric coefficient: 2.0

Protein/13935 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Compound/PW C000006 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-3-Hydroxybutyric acid
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-335
type: UnificationXref
id: CPD-335
db: BioCyc

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3-Hydroxy-3-methylglutaryl-CoA
name: SubPathwayOutput

Reference/HMDB HMDB0001659
type: UnificationXref
id: HMDB0001659
db: HMDB

ChemicalStructure/PW C000006
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)CC(O)=O

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

Reference/PathWhiz PW121889
type: UnificationXref
id: PW121889
db: PathWhiz

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Corticosteroid 11-beta-dehydrogenase isozyme 1
type: Protein
cellular location: Mitochondrion
entity reference: Corticosteroid 11-beta-dehydrogenase isozyme 1

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Complex
component stoichiometry: Protein/14117 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Hydroxymethylglutaryl-CoA lyase, mitochondrial

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Reference/ChemSpider 83181
type: UnificationXref
id: 83181
db: ChemSpider

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt P54869
type: UnificationXref
id: P54869
db: UniProt

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/SMPDB SMP0000051
type: UnificationXref
id: SMP0000051
db: SMPDB

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Acetone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetone

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reaction109658
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
name: 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

Reference/SMPDB SMP0000060
type: UnificationXref
id: SMP0000060
db: SMPDB

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinyl-CoA

ReactionCatalysis100395
type: Catalysis
controller: D-beta-hydroxybutyrate dehydrogenase, mitochondrial
controlled: 1.1.1.30
control type: ACTIVATION

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9D0K2
organism: Mus musculus

D-beta-hydroxybutyrate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/13756 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Corticosteroid 11-beta-dehydrogenase isozyme 1

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P38060
organism: Mus musculus

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency
type: Pathway
pathway order: PathwayTransport/2111011
pathway order: PathwaySubPathway/107946
pathway order: PathwayTransport/2111010
pathway order: PathwaySubPathway/107947
pathway order: PathwayEnzymeReaction/2111004
pathway order: PathwayEnzymeReaction/2111006
pathway order: PathwayEnzymeReaction/2111005
pathway order: PathwayEnzymeReaction/2111008
pathway order: PathwaySubPathway/107944
pathway order: PathwayEnzymeReaction/2111007
pathway order: PathwaySubPathway/107945
pathway order: PathwayEnzymeReaction/2111009
pathway component: Reaction817
pathway component: ReactionCatalysis99917
pathway component: 2.3.3.10
pathway component: Reaction109658
pathway component: 2.8.3.5
pathway component: 4.1.3.4
pathway component: Steroid Biosynthesis
pathway component: 1.1.1.30
pathway component: ReactionCatalysis100395
pathway component: Fatty Acid Metabolism
pathway component: Glycolysis
pathway component: Pyruvate Metabolism
pathway component: Transport1072
pathway component: Transport1071
pathway component: ReactionCatalysis100149
pathway component: ReactionCatalysis100148
pathway component: ReactionCatalysis100147
xref: Reference/SMPDB SMP0120633
xref: Reference/PathWhiz PW121889
organism: Mus musculus

Compound/PW C001063 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Steroid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway107947
pathway component: SubPathwayInteraction107947
xref: Reference/SMPDB SMP0000023
xref: Reference/PathWhiz PW000050
name: SubPathway

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Compound/PW C000808 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

1.1.1.30
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000006 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
right: Acetoacetic acid
right: NADH
spontaneous: false
EC number: 1.1.1.30
left: (R)-3-Hydroxybutyric acid
left: NAD
name: (R)-3-Hydroxybutyric acid + NAD ↔ Acetoacetic acid + NADH
conversion direction: REVERSIBLE

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C001212 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetone
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ChemicalStructure/PW C001212
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)=O

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCatalysis100149
type: Catalysis
controller: Hydroxymethylglutaryl-CoA lyase, mitochondrial
controlled: 4.1.3.4
control type: ACTIVATION

ReactionCatalysis100148
type: Catalysis
controller: 3-oxoacid CoA-transferase 1
controlled: 2.8.3.5
control type: ACTIVATION

ReactionCatalysis100147
type: Catalysis
controller: Hydroxymethylglutaryl-CoA synthase, mitochondrial
controlled: 2.3.3.10
control type: ACTIVATION

SubPathwayInteraction107945
type: Interaction
name: SubPathwayReaction
name: SubPathway107945Reaction
participant: Acetoacetyl-CoA

SubPathwayInteraction107946
type: Interaction
name: SubPathway107946Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

SubPathwayInteraction107947
type: Interaction
name: SubPathway107947Reaction
name: SubPathwayReaction
participant: 3-Hydroxy-3-methylglutaryl-CoA

SubPathwayInteraction107944
type: Interaction
name: SubPathway107944Reaction
name: SubPathwayReaction
participant: Acetoacetyl-CoA

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Compound/PW C001212 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17066
type: UnificationXref
id: CHEBI:17066
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Acetoacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetic acid

Reference/HMDB HMDB0000011
type: UnificationXref
id: HMDB0000011
db: HMDB

Acetone
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Acetone

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbon dioxide

3-oxoacid CoA-transferase 1
type: Complex
component stoichiometry: Protein/13935 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Reaction817
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001212 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
right: Carbon dioxide
right: Acetone
spontaneous: true
left: Acetoacetic acid
name: Acetoacetic acid → Acetone + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt Q9D0K2
type: UnificationXref
id: Q9D0K2
db: UniProt

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

(R)-3-Hydroxybutyric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: (R)-3-Hydroxybutyric acid

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Reference/SMPDB SMP0000023
type: UnificationXref
id: SMP0000023
db: SMPDB

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

2.3.3.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
right: Coenzyme A
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
EC number: 2.3.3.10
left: Acetoacetyl-CoA
left: Water
left: Acetyl-CoA
name: Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

2.8.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Succinic acid
spontaneous: false
EC number: 2.8.3.5
left: Succinyl-CoA
left: Acetoacetic acid
name: Acetoacetic acid + Succinyl-CoA ↔ Acetoacetyl-CoA + Succinic acid
conversion direction: REVERSIBLE

4.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
right: Acetoacetic acid
right: Acetyl-CoA
spontaneous: false
EC number: 4.1.3.4
left: 3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

Transport1072
type: Transport
participant stoichiometry: Compound/PW C001212 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001212 Cytoplasm/Stoichiometry/1.0
right: Acetone
spontaneous: false
left: Acetone
name: Acetone (→) Transport: Mus musculus, Cell, Cytoplasm to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport1071
type: Transport
participant stoichiometry: Compound/PW C001212 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001212 Cytoplasm/Stoichiometry/1.0
right: Acetone
spontaneous: false
left: Acetone
name: Acetone (→) Transport: Mus musculus, Cell, Mitochondrion to Mus musculus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PathWhiz PW000023
type: UnificationXref
id: PW000023
db: PathWhiz

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/CAS 625-72-9
type: UnificationXref
id: 625-72-9
db: CAS

Reference/PubChem-compound 92135
type: UnificationXref
id: 92135
db: PubChem-compound

Reference/ChemSpider 175
type: UnificationXref
id: 175
db: ChemSpider

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Corticosteroid 11-beta-dehydrogenase isozyme 1
type: ProteinReference
xref: Reference/UniProt P50172
organism: Mus musculus

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Acetone
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00207
xref: Reference/PubChem-compound 180
xref: Reference/ChEBI CHEBI 15347
xref: Reference/ChemSpider 175
xref: Reference/HMDB HMDB0001659
xref: Reference/CAS 67-64-1
chemical formula: C3H6O
molecular weight: 58.041866
structure: ChemicalStructure/PW C001212

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

Acetyl-CoA acetyltransferase, mitochondrial
type: Complex
cellular location: Mitochondrion

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/ChEBI CHEBI 15347
type: UnificationXref
id: CHEBI:15347
db: ChEBI

Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Protein/13756 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Corticosteroid 11-beta-dehydrogenase isozyme 1
stoichiometric coefficient: 4.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Hydroxymethylglutaryl-CoA lyase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Hydroxymethylglutaryl-CoA lyase, mitochondrial

Hydroxymethylglutaryl-CoA synthase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Hydroxymethylglutaryl-CoA synthase, mitochondrial

ReactionCatalysis99917
type: Catalysis
controller: Acetyl-CoA acetyltransferase, mitochondrial
controlled: Reaction109658
control type: ACTIVATION

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 180
type: UnificationXref
id: 180
db: PubChem-compound

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0