P50172
UniProt
388357
ChemSpider
C23H38N7O17P3S
Acetyl-CoA
809.1258
439161
PubChem-compound
937
ChemSpider
C01089
KEGG Compound
388353
ChemSpider
439153
PubChem-compound
SMILES
O
Succinic acid
C00207
KEGG Compound
1.0
PW000054
PathWhiz
PW000050
PathWhiz
Acetoacetyl-CoA
SubPathwayOutput
SubPathwayInput
6816
PubChem-compound
Glycolysis
SubPathway
CHEBI:15846
ChEBI
1.0
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
C4H6O3
Acetoacetic acid
102.03169
Acetone
10090
TAXONOMY
1553-55-5
CAS
C4H8O3
(R)-3-Hydroxybutyric acid
104.04734
CHEBI:15380
ChEBI
C25H40N7O19P3S
Succinyl-CoA
867.1312
Acetyl-CoA
SubPathwayOutput
C00332
KEGG Compound
P38060
UniProt
Fatty Acid Metabolism
SubPathway
274
ChemSpider
67-64-1
CAS
CHEBI:16908
ChEBI
Hydroxymethylglutaryl-CoA synthase, mitochondrial
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
SMP0120633
SMPDB
Pyruvate Metabolism
SubPathway
Mus musculus
Mitochondrion
2.0
2.0
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O
1.0
CPD-335
BioCyc
3-Hydroxy-3-methylglutaryl-CoA
SubPathwayOutput
HMDB0001659
HMDB
SMILES
C[C@@H](O)CC(O)=O
C00356
KEGG Compound
PW121889
PathWhiz
SUC
BioCyc
58-68-4
CAS
SMP0000040
SMPDB
HMDB0001423
HMDB
Water
Corticosteroid 11-beta-dehydrogenase isozyme 1
Hydroxymethylglutaryl-CoA lyase, mitochondrial
124-38-9
CAS
94
ChemSpider
83181
ChemSpider
C00001
KEGG Compound
P54869
UniProt
C00004
KEGG Compound
C00003
KEGG Compound
SMP0000051
SMPDB
CHEBI:15741
ChEBI
Acetone
C21H28N7O14P2
NAD
664.11694
C00011
KEGG Compound
SMILES
O=C=O
C00010
KEGG Compound
HMDB0000902
HMDB
Reaction109658
false
2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
REVERSIBLE
1110
PubChem-compound
Extracellular Space
C25H40N7O18P3S
Acetoacetyl-CoA
851.13635
SMP0000060
SMPDB
Succinyl-CoA
ReactionCatalysis100395
ACTIVATION
C21H29N7O14P2
NADH
665.12476
3-HYDROXY-3-METHYL-GLUTARYL-COA
BioCyc
HMDB0001206
HMDB
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
C4H6O4
Succinic acid
118.02661
Hydroxymethylglutaryl-CoA lyase, mitochondrial
388307
ChemSpider
Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency
1.0
53-84-9
CAS
C00024
KEGG Compound
Steroid Biosynthesis
SubPathway
1.0
GO:0005739
GENE ONTOLOGY
1.0
1.1.1.30
false
1.1.1.30
(R)-3-Hydroxybutyric acid + NAD ↔ Acetoacetic acid + NADH
REVERSIBLE
GO:0005615
GENE ONTOLOGY
1.0
GO:0005737
GENE ONTOLOGY
SMILES
CC(C)=O
1.0
ReactionCatalysis100149
ACTIVATION
ReactionCatalysis100148
ACTIVATION
ReactionCatalysis100147
ACTIVATION
SubPathwayInteraction107945
SubPathwayReaction
SubPathway107945Reaction
SubPathwayInteraction107946
SubPathway107946Reaction
SubPathwayReaction
SubPathwayInteraction107947
SubPathway107947Reaction
SubPathwayReaction
SubPathwayInteraction107944
SubPathway107944Reaction
SubPathwayReaction
3-KETOBUTYRATE
BioCyc
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
1.0
CHEBI:17066
ChEBI
5682
ChemSpider
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
CHEBI:1146900
ChEBI
HMDB0000254
HMDB
SMILES
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
SMILES
OC(=O)CCC(O)=O
1.0
1.0
Acetoacetic acid
HMDB0000011
HMDB
Acetone
CO-A
BioCyc
C00164
KEGG Compound
C00042
KEGG Compound
72-89-9
CAS
1078
ChemSpider
Carbon dioxide
3-oxoacid CoA-transferase 1
C21H36N7O16P3S
Coenzyme A
767.11523
604-98-8
CAS
Cytoplasm
ACETOACETYL-COA
BioCyc
Reaction817
true
Acetoacetic acid → Acetone + Carbon dioxide
LEFT_TO_RIGHT
Coenzyme A
6557
ChemSpider
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
7732-18-5
CAS
Q9D0K2
UniProt
388299
ChemSpider
C27H44N7O20P3S
3-Hydroxy-3-methylglutaryl-CoA
911.1575
(R)-3-Hydroxybutyric acid
NAD
HMDB0001487
HMDB
439214
PubChem-compound
SMP0000023
SMPDB
HMDB0001484
HMDB
439218
PubChem-compound
CHEBI:16526
ChEBI
2.3.3.10
false
2.3.3.10
Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A
LEFT_TO_RIGHT
2.8.3.5
false
2.8.3.5
Acetoacetic acid + Succinyl-CoA ↔ Acetoacetyl-CoA + Succinic acid
REVERSIBLE
4.1.3.4
false
4.1.3.4
3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA
LEFT_TO_RIGHT
SMILES
CC(=O)CC(O)=O
Transport1072
false
Acetone (→) Transport: Mus musculus, Cell, Cytoplasm to Mus musculus, Extracellular Space
LEFT_TO_RIGHT
Transport1071
false
Acetone (→) Transport: Mus musculus, Cell, Mitochondrion to Mus musculus, Cell, Cytoplasm
LEFT_TO_RIGHT
NADH
HMDB0001375
HMDB
962
PubChem-compound
PW000023
PathWhiz
392413
ChemSpider
PW000146
PathWhiz
CO2
Carbon dioxide
43.98983
5893
PubChem-compound
110-15-6
CAS
2.0
625-72-9
CAS
92135
PubChem-compound
175
ChemSpider
1420-36-6
CAS
HMDB0002111
HMDB
SMILES
C[C@](O)(CC(O)=O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
HMDB0001022
HMDB
Corticosteroid 11-beta-dehydrogenase isozyme 1
CHEBI:15377
ChEBI
1.0
C00091
KEGG Compound
280
PubChem-compound
C3H6O
Acetone
58.041866
HMDB0000060
HMDB
Acetyl-CoA acetyltransferase, mitochondrial
96
PubChem-compound
CHEBI:15344
ChEBI
CHEBI:15467
ChEBI
CHEBI:15345
ChEBI
444493
PubChem-compound
CHEBI:15347
ChEBI
1.0
ACETYL-COA
BioCyc
H2O
Water
18.010565
541-50-4
CAS
1.0
3-METHYLBENZYLSUCCINYL-COA
BioCyc
NADH
BioCyc
4.0
NAD
BioCyc
Hydroxymethylglutaryl-CoA lyase, mitochondrial
Hydroxymethylglutaryl-CoA synthase, mitochondrial
ReactionCatalysis99917
ACTIVATION
HMDB0001967
HMDB
CHEBI:15351
ChEBI
180
PubChem-compound
85-61-0
CAS
1.0