454-29-5
CAS
C00315
KEGG Compound
7722-84-1
CAS
Q6TXG7
UniProt
937
ChemSpider
Spermidine synthase
CYS
BioCyc
CHEBI:16134
ChEBI
HMDB0003125
HMDB
439153
PubChem-compound
57
ChemSpider
Cystathionine beta-synthase
Cystathionine gamma-lyase
HMDB0000092
HMDB
10-FORMYL-THF
BioCyc
HMDB0000097
HMDB
HMDB0001185
HMDB
HMDB0000099
HMDB
CHEBI:20506
ChEBI
CHEBI:17115
ChEBI
CHEBI:16027
ChEBI
CHEBI:17119
ChEBI
S-adenosylmethionine synthase isoform type-1
D4A7E8
UniProt
C00440
KEGG Compound
CHEBI:17230
ChEBI
ATP
BioCyc
6137
PubChem-compound
PW121977
PathWhiz
5-METHYL-THF
BioCyc
Amine oxidase [flavin-containing] A
18714427
ChemSpider
Methylenetetrahydrofolate reductase
124-20-9
CAS
559142
ChemSpider
βine
Tetrahydrofolic acid
C15H23N6O5S
S-Adenosylmethionine
399.14505
1.0
NADH
5742
ChemSpider
C00213
KEGG Compound
CHEBI:17561
ChEBI
C00212
KEGG Compound
PW000040
PathWhiz
CHEBI:15022
ChEBI
952
ChemSpider
439176
PubChem-compound
439175
PubChem-compound
Methionyl-tRNA synthetase
L-CYSTATHIONINE
BioCyc
SubPathwayInteraction108663
SubPathway108663Reaction
SubPathwayReaction
107-43-7
CAS
SubPathwayInteraction108661
SubPathwayReaction
SubPathway108661Reaction
10-Formyltetrahydrofolate
SubPathwayInteraction108662
SubPathway108662Reaction
SubPathwayReaction
Methionyl-tRNA synthetase
5858
ChemSpider
5736
ChemSpider
Adenosylhomocysteinase
1.0
C00109
KEGG Compound
PW000157
PathWhiz
METHYLENE-THF
BioCyc
CHEBI:16240
ChEBI
824
ChemSpider
1.0
C00101
KEGG Compound
CHEBI:15033
ChEBI
1.0
Rattus norvegicus
PPI
BioCyc
SMILES
NCCCCN
72843-83-5
CAS
CHEBI:17148
ChEBI
1.0
ReactionCatalysis138189
ACTIVATION
ReactionCatalysis138188
ACTIVATION
1.0
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
979-92-0
CAS
Cytosol
P18757
UniProt
1.0
1.0
C00114
KEGG Compound
C00234
KEGG Compound
C14H20N6O5S
S-Adenosylhomocysteine
384.12158
SARCOSINE
BioCyc
Dimethylglycine
122347
PubChem-compound
1.0
ReactionCatalysis138185
ACTIVATION
ReactionCatalysis138184
ACTIVATION
ReactionCatalysis138187
ACTIVATION
ReactionCatalysis138186
ACTIVATION
ReactionCatalysis138181
ACTIVATION
ReactionCatalysis138180
ACTIVATION
Glycine
ReactionCatalysis138183
ACTIVATION
ReactionCatalysis138182
ACTIVATION
C00009
KEGG Compound
110-60-1
CAS
C00007
KEGG Compound
C00001
KEGG Compound
Adenosine
CHEBI:18361
ChEBI
388321
ChemSpider
C00004
KEGG Compound
CHEBI:18367
ChEBI
135-16-0
CAS
C00003
KEGG Compound
2-OXOBUTANOATE
BioCyc
1032
ChemSpider
1.0
388320
ChemSpider
C00002
KEGG Compound
CHEBI:49033
ChEBI
ReactionCatalysis138190
ACTIVATION
Q5U2R0
UniProt
C00019
KEGG Compound
Methionyl-tRNA formyltransferase, mitochondrial
1.0
S-adenosylmethionine decarboxylase proenzyme
C21H28N7O14P2
NAD
664.11694
CHEBI:17482
ChEBI
C00011
KEGG Compound
HMDB0000902
HMDB
C00014
KEGG Compound
C00134
KEGG Compound
C00013
KEGG Compound
Betaine--homocysteine S-methyltransferase 1
Q68FT5
UniProt
Q99MI5
UniProt
C7H19N3
Spermidine
145.1579
12126
ChemSpider
388301
ChemSpider
1057
ChemSpider
ReactionCatalysis138179
ACTIVATION
SMILES
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
C00143
KEGG Compound
MET
BioCyc
C00263
KEGG Compound
C00021
KEGG Compound
56-65-5
CAS
53-84-9
CAS
56-88-2
CAS
5653
ChemSpider
C00020
KEGG Compound
C00027
KEGG Compound
3432-99-3
CAS
1118-68-9
CAS
C5H11NO2S
L-Methionine
149.05106
PUTRESCINE
BioCyc
52-90-4
CAS
C00037
KEGG Compound
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
653
ChemSpider
AMP
BioCyc
Methionine-R-sulfoxide reductase B2, mitochondrial
HYDROGEN-PEROXIDE
BioCyc
CHEBI:29173
ChEBI
L-Methionyl-tRNA(Met)
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
N-formylmethionyl-tRNA(fMet)
C01137
KEGG Compound
107-97-1
CAS
Methionine-R-sulfoxide reductase B2, mitochondrial
5-Methylthioribose 1-phosphate
SMILES
C[N+](C)(C)CCO
SMILES
CNCC(O)=O
763
ChemSpider
SMILES
N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
C00170
KEGG Compound
2.0
388529
ChemSpider
SMILES
CN(C)CC(O)=O
Choline dehydrogenase, mitochondrial
Q9Z2Q4
UniProt
1.0
1.0
CPD-479
BioCyc
784
PubChem-compound
53477720
PubChem-compound
1.0
305
PubChem-compound
12647
PubChem-compound
7732-18-5
CAS
C01026
KEGG Compound
4.0
HMDB0001487
HMDB
61-19-8
CAS
Reduced acceptor
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
SMILES
C[N+](C)(C)CC([O-])=O
AMMONIA
BioCyc
SMILES
N
SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1
63-68-3
CAS
HMDB0000271
HMDB
5,10-Methylene-THF
C6H13O7PS
5-Methylthioribose 1-phosphate
260.01196
5907
ChemSpider
NAD
Adenosylhomocysteinase
C10H16N5O13P3
Adenosine triphosphate
506.99576
C20H23N7O7
10-Formyltetrahydrofolate
473.1659
56-40-6
CAS
C00065
KEGG Compound
1.0
58-61-7
CAS
2800-34-2
CAS
Methionine adenosyltransferase 2 subunit beta
HMDB0001377
HMDB
S-Adenosylhomocysteine
HMDB0000045
HMDB
HMDB0001257
HMDB
1.0
C00073
KEGG Compound
C14H23N6O3S
S-Adenosylmethioninamine
355.15524
HMDB0000043
HMDB
962
PubChem-compound
DIMETHYL-GLYCINE
BioCyc
31983
ChemSpider
Methionine sulfoxide
Amine oxidase [flavin-containing] A
CO2
Carbon dioxide
43.98983
Hydrogen peroxide
P17708
UniProt
730
ChemSpider
BETAINE
BioCyc
SMILES
O=O
583-92-6
CAS
HMDB0000051
HMDB
847
PubChem-compound
HMDB0000050
HMDB
1.0
HMDB0002111
HMDB
βine
C4H9NO2S
Homocysteine
135.0354
Methylenetetrahydrofolate reductase
14265-44-2
CAS
Cystathionine gamma-lyase
Putrescine
1.0
HOMO-CYS
BioCyc
HMDB0002005
HMDB
C01180
KEGG Compound
2.0
SMILES
CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2
S-adenosylmethionine decarboxylase proenzyme
C4H6O3
2-Ketobutyric acid
102.03169
1.0
C3H7NO3
L-Serine
105.042595
SMILES
CSCCC(=O)C(O)=O
HMDB0000187
HMDB
1.0
HMDB0001396
HMDB
Methionine synthase
1.0
C3H7NO2S
L-Cysteine
121.01975
644102
PubChem-compound
6083
PubChem-compound
CHEBI:33574
ChEBI
1.0
C00097
KEGG Compound
757
ChemSpider
N-formylmethionyl-tRNA(fMet)
Glycine
25246222
PubChem-compound
1.0
1.0
H2O
Water
18.010565
H2O2
Hydrogen peroxide
34.005478
D3Z941
UniProt
SMILES
NCC(O)=O
54923
ChemSpider
1.0
NADH
BioCyc
C4H9NO3
L-Homoserine
119.05824
Nucleus
NAD
BioCyc
Choline
1.0
S-methyl-5'-thioadenosine phosphorylase
977
PubChem-compound
DNA (cytosine-5)-methyltransferase 1
SPERMIDINE
BioCyc
1.0
62-49-7
CAS
1.0
C02291
KEGG Compound
SMILES
[H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O
134-35-0
CAS
L-Homoserine
SubPathwayOutput
DNA (cytosine-5)-methyltransferase 1
HMDB0001173
HMDB
247
PubChem-compound
Methylenetetrahydrofolate reductase
2457-80-9
CAS
L-Methionine
SMILES
N[C@@H](CS)C(O)=O
1.0
C05330
KEGG Compound
1.0
SMILES
N[C@@H](CCO)C(O)=O
Adenosine monophosphate
SMILES
O
13837702
ChemSpider
SMILES
OO
Q9WU57
UniProt
H3N
Ammonia
17.026548
C10H13N5O4
Adenosine
267.09674
Q6UPE0
UniProt
1.0
C10H14N5O7P
Adenosine monophosphate
347.06308
Hypermethioninemia
ReactionCatalysis2650
ACTIVATION
C5H11NO2
βine
117.07898
2.1.2.9
false
2.1.2.9
10-Formyltetrahydrofolate + L-Methionyl-tRNA(Met) → N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid
LEFT_TO_RIGHT
CHEBI:15611
ChEBI
1.0
HMDB0000538
HMDB
Serine hydroxymethyltransferase
1.0
S-ADENOSYLMETHIONINAMINE
BioCyc
473
PubChem-compound
S-Adenosylmethionine
Sulfate/Sulfite Metabolism
SubPathway
242
ChemSpider
Serine hydroxymethyltransferase
2-Ketobutyric acid
CHEBI:15846
ChEBI
5-Methyltetrahydrofolic acid
1.5.1.20
false
1.5.1.20
5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD
LEFT_TO_RIGHT
58
PubChem-compound
49791978
PubChem-compound
L-Cystathionine
Methionyl-tRNA formyltransferase, mitochondrial
ReactionCatalysis137432
ACTIVATION
P13444
UniProt
SMILES
CSCC[C@H](N)C(O)=O
Acceptor
GO:0005829
GENE ONTOLOGY
C19H23N7O6
Tetrahydrofolic acid
445.171
C5H11NO3S
Methionine sulfoxide
165.04596
274
ChemSpider
Purine nucleoside phosphorylase
S-adenosylmethionine synthase
CHEBI:16908
ChEBI
Ammonia
ADENOSYL-HOMO-CYS
BioCyc
S-Adenosylhomocysteine
Pyrophosphate
485-80-3
CAS
O4P
Phosphate
94.95342
Cystathionine gamma-lyase
5862
PubChem-compound
SER
BioCyc
HMDB0001533
HMDB
HMDB0001414
HMDB
600-18-0
CAS
Mitochondrion
THF
BioCyc
S-Adenosylmethioninamine
CHEBI:15641
ChEBI
GLY
BioCyc
Q4FZX5
UniProt
CHEBI:16610
ChEBI
672-15-1
CAS
Carbon dioxide
CPD-6641
BioCyc
L-Methionyl-tRNA(Met)
1.0
217
ChemSpider
SMILES
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1
58-68-4
CAS
HMDB0000574
HMDB
SMILES
CS(=O)CCC(N)C(O)=O
HMDB0000696
HMDB
SMILES
[O-]P([O-])([O-])=O
124-38-9
CAS
CHEBI:15637
ChEBI
C2H5NO2
Glycine
75.03203
SMP0000041
SMPDB
CHEBI:15414
ChEBI
HMDB0001429
HMDB
1.0
CHEBI:27859
ChEBI
1.0
673
PubChem-compound
HMDB0001553
HMDB
5257127
PubChem-compound
C20H23N7O6
5,10-Methylene-THF
457.171
GO:0005634
GENE ONTOLOGY
7664-41-7
CAS
Glycine and Serine Metabolism
SubPathway
60961
PubChem-compound
CHEBI:15625
ChEBI
S-ADENOSYLMETHIONINE
BioCyc
SMILES
O=C=O
5951
PubChem-compound
222
PubChem-compound
Homocysteine
SubPathwayOutput
O7P2
Pyrophosphate
173.91193
C04188
KEGG Compound
C21H29N7O14P2
NADH
665.12476
5957
PubChem-compound
2.5.1.16
false
2.5.1.16
Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Spermidine
LEFT_TO_RIGHT
SMILES
NC(CCS)C(O)=O
439415
PubChem-compound
A6KEC5
UniProt
Cysteine Metabolism
SubPathway
Methionine synthase
tRNA(Met)
S-methylmethionine--homocysteine S-methyltransferase BHMT2
22365-13-5
CAS
ReactionCatalysis137403
ACTIVATION
CPD-444
BioCyc
Q5I0C5
UniProt
CHEBI:15636
ChEBI
CPD-563
BioCyc
1.0
1102
PubChem-compound
ReactionCatalysis137409
ACTIVATION
reduced thioredoxin
HMDB0000123
HMDB
SMILES
N[C@@H](CO)C(O)=O
Adenosine triphosphate
GO:0005739
GENE ONTOLOGY
ReactionCatalysis2648
ACTIVATION
S-methylmethionine--homocysteine S-methyltransferase BHMT2
HMDB0000005
HMDB
SMILES
CCC(=O)C(O)=O
ReactionCatalysis2647
ACTIVATION
ReactionCatalysis2649
ACTIVATION
460
ChemSpider
4.0
4.0
C7H14N2O4S
L-Cystathionine
222.06743
C5H14NO
Choline
104.10754
C3H7NO2
Sarcosine
89.047676
C4H9NO2
Dimethylglycine
103.06333
S-adenosylmethionine decarboxylase proenzyme
2.0
Methionine adenosyltransferase 2 subunit beta
S-adenosylmethionine synthase isoform type-1
Choline dehydrogenase, mitochondrial
Adenosylhomocysteinase
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
CPD-8587
BioCyc
10116
TAXONOMY
Q63817
UniProt
2.1.2.1
false
2.1.2.1
L-Serine + Tetrahydrofolic acid → 5,10-Methylene-THF + Glycine + Water
LEFT_TO_RIGHT
5682
ChemSpider
4.4.1.1
false
4.4.1.1
L-Cystathionine + Water → 2-Ketobutyric acid + L-Cysteine
LEFT_TO_RIGHT
Purine nucleoside phosphorylase
CHEBI:30831
ChEBI
4.2.1.22
false
4.2.1.22
L-Homoserine + L-Serine → L-Cystathionine + Water
LEFT_TO_RIGHT
2.1.1.5
false
2.1.1.5
L-Cystathionine → Homocysteine
LEFT_TO_RIGHT
2.1.1.37
false
2.1.1.37
Glycine + S-Adenosylmethionine → S-Adenosylhomocysteine + Sarcosine
LEFT_TO_RIGHT
oxidized thioredoxin
4.1.1.50
false
4.1.1.50
S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine
LEFT_TO_RIGHT
2.4.2.28
false
2.4.2.28
5'-Methylthioadenosine + Phosphate → 5-Methylthioribose 1-phosphate + L-Methionine
LEFT_TO_RIGHT
SMILES
NCCCCNCCCN
1.0
1.0
SMP0000004
SMPDB
C00719
KEGG Compound
5-METHYLTHIOADENOSINE
BioCyc
1.0
oxidized thioredoxin
14000-31-8
CAS
4.0
CHEBI:15699
ChEBI
CHEBI:15339
ChEBI
4.0
1.4.3.2
false
1.4.3.2
L-Methionine + Oxygen + Water → 2-Oxo-4-methylthiobutanoic acid + Ammonia + Hydrogen peroxide
LEFT_TO_RIGHT
1071
ChemSpider
Reaction147921
false
Adenosine triphosphate + L-Methionine + tRNA(Met) → Adenosine monophosphate + L-Methionyl-tRNA(Met) + Pyrophosphate
LEFT_TO_RIGHT
CHEBI:17750
ChEBI
1.1.99.1
false
1.1.99.1
Acceptor + Choline → Reduced acceptor + βine
LEFT_TO_RIGHT
1.8.4.-
false
1.8.4.-
L-Methionine + oxidized thioredoxin → Methionine sulfoxide + reduced thioredoxin
LEFT_TO_RIGHT
1088
PubChem-compound
S-Adenosylmethionine
1.8.4.-
false
1.8.4.-
L-Methionine + oxidized thioredoxin → Methionine sulfoxide + reduced thioredoxin
LEFT_TO_RIGHT
HMDB0000939
HMDB
CHEBI:17509
ChEBI
SMP0000013
SMPDB
C4H12N2
Putrescine
88.10005
1.0
CHEBI:15422
ChEBI
CHEBI:16635
ChEBI
CHEBI:17724
ChEBI
388299
ChemSpider
Acceptor
1.0
Reduced acceptor
3.0
1.0
O2
Oxygen
31.98983
2-Oxo-4-methylthiobutanoic acid
4.2.1.22
false
4.2.1.22
Homocysteine + L-Serine → L-Cystathionine + Water
LEFT_TO_RIGHT
Water
1.0
CHEBI:16643
ChEBI
P32232
UniProt
CHEBI:16526
ChEBI
HMDB0000719
HMDB
7782-44-7
CAS
C5H8O3S
2-Oxo-4-methylthiobutanoic acid
148.01941
Serine hydroxymethyltransferase, cytosolic
HMDB0000963
HMDB
C20H25N7O6
5-Methyltetrahydrofolic acid
459.18665
Spermidine synthase
CHEBI:15428
ChEBI
1.0
CHEBI:16335
ChEBI
1.0
388392
ChemSpider
L-Methionine
5893
PubChem-compound
L-METHIONINE_SULFOXIDE
BioCyc
SMILES
CSCC1OC(OP(O)(O)=O)[C@H](O)[C@@H]1O
439234
PubChem-compound
HMDB0000972
HMDB
SMILES
NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1
299
ChemSpider
5'-Methylthioadenosine
PW000018
PathWhiz
L-Serine
ADENOSINE
BioCyc
CHEBI:15377
ChEBI
L-Cysteine
SubPathwayOutput
CHEBI:15379
ChEBI
C11H15N5O3S
5'-Methylthioadenosine
297.08957
P10760
UniProt
56-45-1
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1045
PubChem-compound
Phosphate
Oxygen
62697-73-8
CAS
HMDB0000742
HMDB
280
PubChem-compound
SMILES
C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
2.5.1.6
false
2.5.1.6
Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
LEFT_TO_RIGHT
3.3.1.1
false
3.3.1.1
S-Adenosylhomocysteine + Water → Adenosine + Homocysteine
LEFT_TO_RIGHT
2.1.1.5
false
2.1.1.5
Homocysteine + βine → Dimethylglycine + L-Methionine
LEFT_TO_RIGHT
2.1.1.13
false
2.1.1.13
5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid
LEFT_TO_RIGHT
1.0
ReactionCatalysis137476
ACTIVATION
25243997
PubChem-compound
HMDB0000988
HMDB
1.0
1.0
388371
ChemSpider
SMILES
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O
HOMO-SER
BioCyc
4.0
Cystathionine beta-synthase
Spermidine
tRNA(Met)
Sarcosine
1061
PubChem-compound
CHEBI:15354
ChEBI
Spermidine synthase
Cystathionine beta-synthase
109092
ChemSpider
HMDB0001846
HMDB
HMDB0001967
HMDB
CHEBI:16680
ChEBI
24762165
PubChem-compound
reduced thioredoxin
13781857
PubChem-compound
1.0
SMP0120718
SMPDB