Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Unknown
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Unknown

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Alanine--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Alanine--tRNA ligase, cytoplasmic

L-Alanyl-tRNA(Ala)
type: Rna
cellular location: Cytosol
entity reference: L-Alanyl-tRNA(Ala)

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

DNA/1 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Ala)
stoichiometric coefficient: 1.0

DNA/1 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Ala)
stoichiometric coefficient: 1.0

Compound/PW C000075 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyoxylic acid
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Unknown
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Unknown

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Alanine--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P50475
organism: Rattus norvegicus

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Alanine--tRNA ligase, mitochondrial
type: ProteinReference
xref: Reference/UniProt D3ZX08
organism: Rattus norvegicus

Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

RNA/2 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanyl-tRNA(Ala)
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Citric Acid Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108434
pathway component: SubPathwayInteraction108434
xref: Reference/PathWhiz PW000005
xref: Reference/SMPDB SMP0000057
name: SubPathway

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/PathWhiz PW122016
type: UnificationXref
id: PW122016
db: PathWhiz

ReactionCatalysis2567
type: Catalysis
controller: Alanine aminotransferase 1
controlled: 2.6.1.2
control type: ACTIVATION

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
right: Oxalacetic acid
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 6.4.1.1
left: Pyruvic acid
left: Adenosine triphosphate
left: Hydrogen carbonate
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction2596
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000075 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Mitochondrial Matrix/Stoichiometry/1.0
right: Glycine
right: Pyruvic acid
spontaneous: false
left: Glyoxylic acid
left: L-Alanine
name: Glyoxylic acid + L-Alanine ↔ Glycine + Pyruvic acid
conversion direction: REVERSIBLE

ReactionCatalysis2566
type: Catalysis
controller: Alanine--tRNA ligase, mitochondrial
controlled: 6.1.1.7
control type: ACTIVATION

6.1.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: RNA/2 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: RNA/2 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: DNA/1 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: DNA/1 Mitochondrial Matrix/Stoichiometry/1.0
right: Adenosine monophosphate
right: Pyrophosphate
right: L-Alanyl-tRNA(Ala)
spontaneous: false
EC number: 6.1.1.7
left: Adenosine triphosphate
left: L-Alanine
left: tRNA(Ala)
name: Adenosine triphosphate + L-Alanine + tRNA(Ala) → Adenosine monophosphate + L-Alanyl-tRNA(Ala) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis2569
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: 6.4.1.1
control type: ACTIVATION

2.6.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
right: Pyruvic acid
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.2
left: Oxoglutaric acid
left: L-Alanine
name: L-Alanine + Oxoglutaric acid ↔ L-Glutamic acid + Pyruvic acid
conversion direction: REVERSIBLE

Reference/SMPDB SMP0120755
type: UnificationXref
id: SMP0120755
db: SMPDB

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

ReactionCatalysis2565
type: Catalysis
controller: Alanine--tRNA ligase, cytoplasmic
controlled: 6.1.1.7
control type: ACTIVATION

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Protein/7761 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/7760 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Unknown

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Adenosine monophosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine monophosphate

L-Alanyl-tRNA(Ala)
type: Rna
cellular location: Mitochondrial Matrix
entity reference: L-Alanyl-tRNA(Ala)

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

L-Alanine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Alanine

Glyoxylic acid
type: SmallMoleculeReference
xref: Reference/BioCyc GLYOX
xref: Reference/ChemSpider 740
xref: Reference/CAS 298-12-4
xref: Reference/HMDB HMDB0000119
xref: Reference/PubChem-compound 760
xref: Reference/ChEBI CHEBI 16891
xref: Reference/KEGG Compound C00048
chemical formula: C2H2O3
molecular weight: 74.0004
structure: ChemicalStructure/PW C000075

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

tRNA(Ala)
type: DnaReference
xref: Reference/ChEBI CHEBI 29170
organism: Rattus norvegicus

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyrophosphate

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000057
type: UnificationXref
id: SMP0000057
db: SMPDB

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/UniProt P50475
type: UnificationXref
id: P50475
db: UniProt

Compound/PW C000078 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Pyruvate Carboxylase Deficiency
type: Pathway
pathway order: PathwayTransport/2113728
pathway order: PathwayEnzymeReaction/2113724
pathway order: PathwayEnzymeReaction/2113725
pathway order: PathwayEnzymeReaction/2113723
pathway order: PathwaySubPathway/108433
pathway order: PathwaySubPathway/108434
pathway order: PathwayEnzymeReaction/2113726
pathway order: PathwayEnzymeReaction/2113727
pathway component: ReactionCatalysis2567
pathway component: 6.4.1.1
pathway component: Reaction2596
pathway component: ReactionCatalysis2566
pathway component: Transport340
pathway component: 6.1.1.7
pathway component: ReactionCatalysis2569
pathway component: 2.6.1.2
pathway component: ReactionCatalysis2570
pathway component: Selenoamino Acid Metabolism
pathway component: ReactionCatalysis2565
pathway component: Citric Acid Cycle
xref: Reference/PathWhiz PW122016
xref: Reference/SMPDB SMP0120755
organism: Rattus norvegicus

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/HMDB HMDB0000119
type: UnificationXref
id: HMDB0000119
db: HMDB

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Protein/7760 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/CAS 298-12-4
type: UnificationXref
id: 298-12-4
db: CAS

Selenoamino Acid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108433
pathway component: SubPathwayInteraction108433
xref: Reference/SMPDB SMP0000029
xref: Reference/PathWhiz PW000007
name: SubPathway

Protein/7759 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/ChEBI CHEBI 29170
type: UnificationXref
id: CHEBI:29170
db: ChEBI

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Compound/PW C000170 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 760
type: UnificationXref
id: 760
db: PubChem-compound

Reference/ChEBI CHEBI 16891
type: UnificationXref
id: CHEBI:16891
db: ChEBI

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxalacetic acid

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Compound/PW C000463 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Glyoxylic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glyoxylic acid

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00048
type: UnificationXref
id: C00048
db: KEGG Compound

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000105 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Glycine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glycine

Reference/SMPDB SMP0000029
type: UnificationXref
id: SMP0000029
db: SMPDB

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/BioCyc GLYOX
type: UnificationXref
id: GLYOX
db: BioCyc

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Compound/PW C000032 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyruvic acid

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/ChEBI CHEBI 17732
type: UnificationXref
id: CHEBI:17732
db: ChEBI

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

tRNA(Ala)
type: Dna
cellular location: Cytosol
entity reference: tRNA(Ala)

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

L-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Alanine
name: SubPathwayOutput

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Alanine--tRNA ligase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Alanine--tRNA ligase, mitochondrial

tRNA(Ala)
type: Dna
cellular location: Mitochondrial Matrix
entity reference: tRNA(Ala)

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

ReactionCatalysis2570
type: Catalysis
controller: Serine--pyruvate aminotransferase
controlled: Reaction2596
control type: ACTIVATION

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Serine--pyruvate aminotransferase
type: Complex
component stoichiometry: Protein/7761 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Unknown

SubPathwayInteraction108433
type: Interaction
name: SubPathwayReaction
name: SubPathway108433Reaction
participant: L-Alanine

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxalacetic acid
name: SubPathwayInput

SubPathwayInteraction108434
type: Interaction
name: SubPathway108434Reaction
name: SubPathwayReaction
participant: Oxalacetic acid

Reference/PathWhiz PW000007
type: UnificationXref
id: PW000007
db: PathWhiz

L-Alanyl-tRNA(Ala)
type: RnaReference
xref: Reference/ChEBI CHEBI 17732
organism: Rattus norvegicus

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PathWhiz PW000005
type: UnificationXref
id: PW000005
db: PathWhiz

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Unknown
type: ProteinReference
organism: Rattus norvegicus

Reference/UniProt D3ZX08
type: UnificationXref
id: D3ZX08
db: UniProt

Unknown
type: ProteinReference
organism: Rattus norvegicus

ChemicalStructure/PW C000075
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C=O

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Hydrogen carbonate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen carbonate

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Transport340
type: Transport
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: Pyruvic acid
name: Pyruvic acid (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Compound/PW C000164 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

RNA/2 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanyl-tRNA(Ala)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Unknown
type: ProteinReference
organism: Rattus norvegicus

Alanine aminotransferase 1
type: Complex
component stoichiometry: Protein/7759 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/ChemSpider 740
type: UnificationXref
id: 740
db: ChemSpider

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463