Reference/UniProt Q9EQ25
type: UnificationXref
id: Q9EQ25
db: UniProt

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Reference/PathWhiz PW122028
type: UnificationXref
id: PW122028
db: PathWhiz

b(0,+)-type amino acid transporter 1
type: Protein
entity reference: b(0,+)-type amino acid transporter 1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Urea transporter 2
type: Protein
entity reference: Urea transporter 2

Reference/CAS 57-13-6
type: UnificationXref
id: 57-13-6
db: CAS

Reference/ChEBI CHEBI 33709
type: UnificationXref
id: CHEBI:33709
db: ChEBI

Neutral and basic amino acid transport protein rBAT
type: Protein
entity reference: Neutral and basic amino acid transport protein rBAT

TransportCatalysis1334
type: Catalysis
controller: Chloride channel protein ClC-Ka
controlled: Transport10121
control type: ACTIVATION

TransportCatalysis1336
type: Catalysis
controller: Epithelial Sodium Channel
controlled: Transport10127
control type: ACTIVATION

TransportCatalysis1333
type: Catalysis
controller: Unknown
controlled: Transport10119
control type: ACTIVATION

Reference/UniProt Q9QWL4
type: UnificationXref
id: Q9QWL4
db: UniProt

SLC3A2/4F2hc Y+L amino acid transporter 2
type: Complex
component: 4F2 cell-surface antigen heavy chain
component: Y+L amino acid transporter 1

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

SLC3A2/4F2hc Y+L amino acid transporter 1
type: Complex
component: 4F2 cell-surface antigen heavy chain
component: Y+L amino acid transporter 1

L-Cysteine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Cysteine

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/UniProt P97709
type: UnificationXref
id: P97709
db: UniProt

Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
type: Complex
component: b(0,+)-type amino acid transporter 1
component: Neutral and basic amino acid transport protein rBAT

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

TransportCatalysis1339
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
controlled: Transport10129
control type: ACTIVATION

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
type: Complex
component: Large neutral amino acids transporter small subunit 1
component: 4F2 cell-surface antigen heavy chain

TransportCatalysis1338
type: Catalysis
controller: Excitatory amino acid transporter 3
controlled: Transport10128
control type: ACTIVATION

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
type: Complex
component: Large neutral amino acids transporter small subunit 2
component: 4F2 cell-surface antigen heavy chain

Chloride channel protein ClC-Ka
type: ProteinReference
xref: Reference/UniProt P97709

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Imino acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Imino acids

Reference/UniProt Q9Z1G6
type: UnificationXref
id: Q9Z1G6
db: UniProt

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Y+L amino acid transporter 1
type: Protein
entity reference: Y+L amino acid transporter 1

Compound/Generic51 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

TransportCatalysis1346
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 2
controlled: Transport10132
control type: ACTIVATION

TransportCatalysis1345
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 1
controlled: Transport10132
control type: ACTIVATION

TransportCatalysis1348
type: Catalysis
controller: Urea transporter 2
controlled: Transport10134
control type: ACTIVATION

TransportCatalysis1347
type: Catalysis
controller: Urea transporter 2
controlled: Transport10133
control type: ACTIVATION

TransportCatalysis1342
type: Catalysis
controller: Sodium-coupled neutral amino acid transporter 4
controlled: Transport10131
control type: ACTIVATION

TransportCatalysis1341
type: Catalysis
controller: Sodium- and chloride-dependent transporter XTRP3
controlled: Transport10130
control type: ACTIVATION

Reference/UniProt Q794F9
type: UnificationXref
id: Q794F9
db: UniProt

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Compound/PW C000026 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

TransportCatalysis1349
type: Catalysis
controller: Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
controlled: Transport10137
control type: ACTIVATION

Reference/ChemSpider 1143
type: UnificationXref
id: 1143
db: ChemSpider

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Large neutral amino acids transporter small subunit 1
type: Protein
entity reference: Large neutral amino acids transporter small subunit 1

Reference/SMPDB SMP0120767
type: UnificationXref
id: SMP0120767
db: SMPDB

Sodium- and chloride-dependent transporter XTRP3
type: Protein
entity reference: Sodium- and chloride-dependent transporter XTRP3

Reference/BioCyc UREA
type: UnificationXref
id: UREA
db: BioCyc

TransportCatalysis1340
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
controlled: Transport10129
control type: ACTIVATION

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

Compound/Generic39 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Compound/PW C000374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Transport10134
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10135
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Urea
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Urea

Reference/UniProt Q9WUD3
type: UnificationXref
id: Q9WUD3
db: UniProt

Transport10136
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10137
type: Transport
participant stoichiometry: Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
spontaneous: false
left: L-Cysteine
name: L-Cysteine (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Large neutral amino acids transporter small subunit 2
type: Protein
entity reference: Large neutral amino acids transporter small subunit 2

Transport10130
type: Transport
participant stoichiometry: Compound/Generic51 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic51 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Imino acids
right: Chloride ion
right: Sodium
spontaneous: false
left: Imino acids
left: Sodium
left: Chloride ion
name: Imino acids (→), Sodium (→), Chloride ion (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10131
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10132
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10133
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

4F2 cell-surface antigen heavy chain
type: Protein
entity reference: 4F2 cell-surface antigen heavy chain

Reference/ChEBI CHEBI 26271
type: UnificationXref
id: CHEBI:26271
db: ChEBI

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

ChemicalStructure/PW C000200
type: ChemicalStructure
structure format: SMILES
structure data: NC(N)=O

Reference/ChEBI CHEBI 15705
type: UnificationXref
id: CHEBI:15705
db: ChEBI

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Excitatory amino acid transporter 3
type: Protein
entity reference: Excitatory amino acid transporter 3

Reference/UniProt Q64093
type: UnificationXref
id: Q64093
db: UniProt

Imino acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Imino acids

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Iminoglycinuria
type: Pathway
pathway order: PathwaySubPathway/109343
pathway order: PathwayTransport/2119019
pathway order: PathwayTransport/2119018
pathway order: PathwayTransport/2119029
pathway order: PathwayTransport/2119017
pathway order: PathwayTransport/2119028
pathway order: PathwayTransport/2119016
pathway order: PathwayTransport/2119027
pathway order: PathwayTransport/2119038
pathway order: PathwayTransport/2119022
pathway order: PathwayTransport/2119021
pathway order: PathwayTransport/2119020
pathway order: PathwayTransport/2119031
pathway order: PathwayTransport/2119030
pathway order: PathwayTransport/2119026
pathway order: PathwayTransport/2119037
pathway order: PathwayTransport/2119025
pathway order: PathwayTransport/2119036
pathway order: PathwayTransport/2119024
pathway order: PathwayTransport/2119035
pathway order: PathwayTransport/2119023
pathway order: PathwayTransport/2119034
pathway component: TransportCatalysis1346
pathway component: TransportCatalysis1345
pathway component: TransportCatalysis1348
pathway component: TransportCatalysis1347
pathway component: TransportCatalysis1342
pathway component: TransportCatalysis1341
pathway component: Transport10127
pathway component: Transport10128
pathway component: Transport10129
pathway component: Transport10123
pathway component: Transport10124
pathway component: TransportCatalysis1349
pathway component: Transport10125
pathway component: Transport10126
pathway component: Transport10120
pathway component: Transport10121
pathway component: Transport10122
pathway component: Transcription/Translation
pathway component: TransportCatalysis1340
pathway component: TransportCatalysis1334
pathway component: TransportCatalysis1336
pathway component: TransportCatalysis1333
pathway component: Transport10119
pathway component: TransportCatalysis1339
pathway component: Transport10134
pathway component: TransportCatalysis1338
pathway component: Transport10135
pathway component: Transport10136
pathway component: Transport10137
pathway component: Transport10130
pathway component: Transport10131
pathway component: Transport10132
pathway component: Transport10133
xref: Reference/SMPDB SMP0120767
xref: Reference/PathWhiz PW122028
organism: Rattus norvegicus

Transport10127
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10128
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: L-Amino acid
right: Sodium
spontaneous: false
left: Sodium
left: L-Amino acid
name: L-Amino acid (→), Sodium (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

L-Amino acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15705

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Transport10129
type: Transport
participant stoichiometry: Compound/Generic50 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic50 Extracellular Space/Stoichiometry/1.0
right: Large Neutral Amino Acids
spontaneous: false
left: Large Neutral Amino Acids
name: Large Neutral Amino Acids (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Transport10123
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
left: Potassium
name: Sodium (→), Potassium (→), Chloride ion (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10124
type: Transport
participant stoichiometry: Compound/Generic32 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic32 Cytosol/Stoichiometry/1.0
right: Organic Anion
spontaneous: false
left: Organic Anion
name: Organic Anion (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Large Neutral Amino Acids

Transport10125
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
spontaneous: false
left: Chloride ion
left: Potassium
name: Chloride ion (→), Potassium (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10126
type: Transport
participant stoichiometry: Compound/Generic39 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic39 Extracellular Space/Stoichiometry/1.0
right: Organic Cation
spontaneous: false
left: Organic Cation
name: Organic Cation (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Transport10120
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10121
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
right: Chloride ion
spontaneous: false
left: Chloride ion
name: Chloride ion (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Transport10122
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (↔) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Chloride ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chloride ion

Y+L amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt Q9QZ66

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 25697
type: UnificationXref
id: CHEBI:25697
db: ChEBI

Reference/ChEBI CHEBI 25696
type: UnificationXref
id: CHEBI:25696
db: ChEBI

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

b(0,+)-type amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt Q4KM04

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Transport10119
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
name: Chloride ion (→), Sodium (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Urea
type: SmallMolecule
cellular location: Cytosol
entity reference: Urea

Urea transporter 2
type: ProteinReference
xref: Reference/UniProt Q9Z2R3

Reference/UniProt P13638
type: UnificationXref
id: P13638
db: UniProt

Compound/Generic50 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Neutral and basic amino acid transport protein rBAT
type: ProteinReference
xref: Reference/UniProt Q62672

Reference/UniProt Q4KM04
type: UnificationXref
id: Q4KM04
db: UniProt

Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Reference/UniProt Q63062
type: UnificationXref
id: Q63062
db: UniProt

Reference/UniProt Q9Z2R3
type: UnificationXref
id: Q9Z2R3
db: UniProt

Organic Anion
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Anion

Reference/UniProt Q64609
type: UnificationXref
id: Q64609
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/UniProt Q9WVR6
type: UnificationXref
id: Q9WVR6
db: UniProt

Transcription/Translation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109343
pathway component: SubPathwayInteraction109343
xref: Reference/SMPDB SMP0000019
xref: Reference/PathWhiz PW000455
name: SubPathway

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Reference/UniProt Q62672
type: UnificationXref
id: Q62672
db: UniProt

Reference/UniProt P06686
type: UnificationXref
id: P06686
db: UniProt

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Large Neutral Amino Acids

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/Generic32 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Organic Anion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Anion

Protein/7758 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Reference/UniProt Q63377
type: UnificationXref
id: Q63377
db: UniProt

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Unknown
type: Protein
cellular location: Nucleus
entity reference: Unknown

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Compound/Generic39 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

ProteinComplex/10964 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/SMPDB SMP0000019
type: UnificationXref
id: SMP0000019
db: SMPDB

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000455
type: UnificationXref
id: PW000455
db: PathWhiz

Active Mineralocorticoid receptor
type: Complex
component stoichiometry: Protein/7758 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Unknown

Compound/Generic5 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Unknown
type: Protein
entity reference: Unknown

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Compound/PW C000200 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Imino acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26271

Sodium-coupled neutral amino acid transporter 4
type: Protein
entity reference: Sodium-coupled neutral amino acid transporter 4

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Reference/UniProt Q9JJP8
type: UnificationXref
id: Q9JJP8
db: UniProt

Urea
type: SmallMoleculeReference
xref: Reference/BioCyc UREA
xref: Reference/CAS 57-13-6
xref: Reference/KEGG Compound C00086
xref: Reference/HMDB HMDB0000294
xref: Reference/ChemSpider 1143
xref: Reference/PubChem-compound 1176
xref: Reference/ChEBI CHEBI 16199
chemical formula: CH4N2O
molecular weight: 60.032364
structure: ChemicalStructure/PW C000200

Epithelial Sodium Channel
type: Complex
cellular location: Cell Membrane
component: Unknown
name: SubPathwayOutput

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Aldosterone
type: SmallMolecule
cellular location: Nucleus
entity reference: Aldosterone

4F2 cell-surface antigen heavy chain
type: ProteinReference
xref: Reference/UniProt Q794F9

Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Large neutral amino acids transporter small subunit 2
type: ProteinReference
xref: Reference/UniProt Q9WVR6

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Compound/Generic5 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Excitatory amino acid transporter 3
type: ProteinReference
xref: Reference/UniProt Q9JJP8

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 16199
type: UnificationXref
id: CHEBI:16199
db: ChEBI

L-Amino acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Amino acid

Large Neutral Amino Acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 33709

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Active Mineralocorticoid receptor (Rattus norvegicus)_Aldosterone
type: Complex
component stoichiometry: ProteinComplex/10964 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C000026 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aldosterone
component: Active Mineralocorticoid receptor
name: SubPathwayInput

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Sodium/potassium ATPase
type: Complex
cellular location: Cell Membrane
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Unknown
component: Sodium/potassium-transporting ATPase subunit alpha-3
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit gamma
name: SubPathwayOutput

Organic Cation
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25697

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

Organic Anion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25696

Sodium- and chloride-dependent transporter XTRP3
type: ProteinReference
xref: Reference/UniProt Q64093

Compound/Generic32 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Large neutral amino acids transporter small subunit 1
type: ProteinReference
xref: Reference/UniProt Q9QWL4

SubPathwayInteraction109343
type: Interaction
name: SubPathway109343Reaction
name: SubPathwayReaction
participant: Sodium/potassium ATPase
participant: Active Mineralocorticoid receptor (Rattus norvegicus)_Aldosterone
participant: Epithelial Sodium Channel

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q63062
organism: Rattus norvegicus

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/UniProt Q64541
type: UnificationXref
id: Q64541
db: UniProt

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1176
type: UnificationXref
id: 1176
db: PubChem-compound

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Organic Cation
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Cation

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt Q64609
organism: Rattus norvegicus

Compound/PW C000374 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Sodium-coupled neutral amino acid transporter 4
type: ProteinReference
xref: Reference/UniProt Q9EQ25

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P06686
organism: Rattus norvegicus

Chloride channel protein ClC-Ka
type: Protein
entity reference: Chloride channel protein ClC-Ka

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Hydrogen carbonate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen carbonate

Reference/HMDB HMDB0000294
type: UnificationXref
id: HMDB0000294
db: HMDB

Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt Q9Z1G6
organism: Rattus norvegicus

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q64541
organism: Rattus norvegicus

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/KEGG Compound C00086
type: UnificationXref
id: C00086
db: KEGG Compound

Compound/Generic51 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Reference/UniProt Q9QZ66
type: UnificationXref
id: Q9QZ66
db: UniProt

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P13638
organism: Rattus norvegicus

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt Q63377
organism: Rattus norvegicus

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt Q9WUD3
organism: Rattus norvegicus

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Unknown
type: ProteinReference

L-Amino acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Amino acid

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Epithelial Sodium Channel
type: Complex
component: Unknown

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Organic Cation
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Cation

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Compound/Generic50 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0