6022
PubChem-compound
Unknown
C23H38N7O17P3S
Acetyl-CoA
809.1258
439161
PubChem-compound
937
ChemSpider
C00311
KEGG Compound
CHEBI:30797
ChEBI
439153
PubChem-compound
1.0
110-17-8
CAS
1.0
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
HMDB0000094
HMDB
Q6P7S4
UniProt
50
ChemSpider
Succinate dehydrogenase complex subunit C
1.0
PW000054
PathWhiz
OXALACETIC_ACID
BioCyc
ATP
BioCyc
PW000051
PathWhiz
Q68FX0
UniProt
HMDB0001072
HMDB
Q641Z9
UniProt
HMDB0001197
HMDB
Aconitate hydratase, mitochondrial
SubPathwayInteraction108418
SubPathway108418Reaction
SubPathwayReaction
PW000046
PathWhiz
SubPathwayInteraction108419
SubPathwayReaction
SubPathway108419Reaction
PW000165
PathWhiz
SubPathwayInteraction108414
SubPathway108414Reaction
SubPathwayReaction
CHEBI:16238
ChEBI
SubPathwayInteraction108415
SubPathwayReaction
SubPathway108415Reaction
SubPathwayInteraction108416
SubPathwayReaction
SubPathway108416Reaction
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
HCO3
BioCyc
Q920L2
UniProt
SubPathwayInteraction108417
SubPathway108417Reaction
SubPathwayReaction
CHEBI:15380
ChEBI
5742
ChemSpider
C25H40N7O19P3S
Succinyl-CoA
867.1312
PW000163
PathWhiz
PW000162
PathWhiz
1.0
4.2.1.3
false
4.2.1.3
Water + cis-Aconitic acid ↔ Isocitric acid
REVERSIBLE
4.2.1.3
false
4.2.1.3
Citric acid ↔ Water + cis-Aconitic acid
REVERSIBLE
1.3.5.1
false
1.3.5.1
Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2
REVERSIBLE
Reaction146993
false
L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
REVERSIBLE
SubPathwayInteraction108421
SubPathwayReaction
SubPathway108421Reaction
4.2.1.2
false
4.2.1.2
L-Malic acid ↔ Fumaric acid + Water
REVERSIBLE
SubPathwayInteraction108422
SubPathwayReaction
SubPathway108422Reaction
Reaction146991
false
Guanosine diphosphate + Phosphate + Succinyl-CoA ↔ Coenzyme A + Guanosine triphosphate + Succinic acid
REVERSIBLE
SubPathwayInteraction108423
SubPathway108423Reaction
SubPathwayReaction
1.2.4.2
false
1.2.4.2
Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA
LEFT_TO_RIGHT
5281915
PubChem-compound
SubPathwayInteraction108424
SubPathwayReaction
SubPathway108424Reaction
97-67-6
CAS
SubPathwayInteraction108420
SubPathway108420Reaction
SubPathwayReaction
1.0
SubPathwayInteraction108407
SubPathwayReaction
SubPathway108407Reaction
SubPathwayInteraction108408
SubPathwayReaction
SubPathway108408Reaction
PW000155
PathWhiz
SubPathwayInteraction108409
SubPathway108409Reaction
SubPathwayReaction
C27H35N9O15P2
FADH
787.1728
Carbon dioxide
4.0
SubPathwayInteraction108406
SubPathway108406Reaction
SubPathwayReaction
945
ChemSpider
Succinyl-CoA ligase
PW000152
PathWhiz
PW000030
PathWhiz
1010
ChemSpider
C10H15N5O11P2
Guanosine diphosphate
443.02432
6.4.1.1
false
6.4.1.1
Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
LEFT_TO_RIGHT
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
1.0
1.1.1.41
false
1.1.1.41
Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid
LEFT_TO_RIGHT
2.3.3.1
false
2.3.3.1
Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A
LEFT_TO_RIGHT
1.2.4.1
false
1.2.4.1
Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH
LEFT_TO_RIGHT
CHEBI:30769
ChEBI
Rattus norvegicus
CHEBI:30887
ChEBI
1.0
SubPathwayInteraction108410
SubPathwayReaction
SubPathway108410Reaction
Q6P6R2
UniProt
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
SubPathwayInteraction108411
SubPathwayReaction
SubPathway108411Reaction
SubPathwayInteraction108412
SubPathway108412Reaction
SubPathwayReaction
SubPathwayInteraction108413
SubPathway108413Reaction
SubPathwayReaction
PW000029
PathWhiz
1.0
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O
C10H16N5O14P3
Guanosine triphosphate
522.99066
1161
ChemSpider
Cytosol
SUC
BioCyc
1.0
C00009
KEGG Compound
C00008
KEGG Compound
1.0
C00001
KEGG Compound
C00122
KEGG Compound
559059
ChemSpider
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1
NADH
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
Dihydrolipoyl dehydrogenase, mitochondrial
C00004
KEGG Compound
CHEBI:18367
ChEBI
C00003
KEGG Compound
1032
ChemSpider
1910-41-4
CAS
1031
ChemSpider
C00002
KEGG Compound
Fumarate hydratase, mitochondrial
Coenzyme A
Mitochondrial Inner Membrane
24.0
C11378
KEGG Compound
C59H90O4
Coenzyme Q10
862.6839
C27H33N9O15P2
FAD
785.1571
Pyruvic acid
SubPathwayOutput
SubPathwayInput
C21H28N7O14P2
NAD
664.11694
1.0
C00011
KEGG Compound
C00010
KEGG Compound
HMDB0000902
HMDB
C00016
KEGG Compound
FAD
P26284
UniProt
1.0
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
FADH
SubPathwayInput
H
Hydrogen Ion
1.007825
C00149
KEGG Compound
388307
ChemSpider
Phosphate
C00022
KEGG Compound
56-65-5
CAS
C01352
KEGG Compound
53-84-9
CAS
C00026
KEGG Compound
C00024
KEGG Compound
4.0
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Fumaric acid
SubPathwayOutput
Q8VHF5
UniProt
C00390
KEGG Compound
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
1.0
769
PubChem-compound
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
56275-39-9
CAS
C00158
KEGG Compound
C00036
KEGG Compound
C00035
KEGG Compound
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
328-50-7
CAS
HMDB0000134
HMDB
HMDB0000254
HMDB
SMILES
OC(=O)CCC(O)=O
1.0
SMILES
OC(=O)C\C(=C\C(O)=O)C(O)=O
HMDB0001341
HMDB
1.0
C00044
KEGG Compound
C00042
KEGG Compound
4445197
ChemSpider
C00288
KEGG Compound
303-98-0
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
SMILES
OC(=O)CC(O)(CC(O)=O)C(O)=O
604-98-8
CAS
cis-Aconitic acid
Q6AY95
UniProt
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Succinyl-CoA
10197150
ChemSpider
FUM
BioCyc
Succinate dehydrogenase
SMILES
OC(=O)CC(=O)C(O)=O
7732-18-5
CAS
CHEBI:18012
ChEBI
HMDB0001487
HMDB
HMDB0000156
HMDB
Mitochondrial pyruvate carrier 1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
HMDB0001248
HMDB
Pyruvic acid
1.0
60.0
C10H16N5O13P3
Adenosine triphosphate
506.99576
SMILES
COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC
NAD
305
ChemSpider
SMILES
CC(=O)C(O)=O
Q5XI35
UniProt
962
PubChem-compound
1.0
5800
ChemSpider
CO2
Carbon dioxide
43.98983
Succinate-CoA ligase subunit beta
Oxoglutarate dehydrogenase complex
C00080
KEGG Compound
Water
Glutamate Metabolism
SubPathway
Ketone Body Metabolism
SubPathway
HMDB0002111
HMDB
HMDB0001022
HMDB
Adenosine diphosphate
SubPathwayInteraction108429
SubPathway108429Reaction
SubPathwayReaction
146-14-5
CAS
14265-44-2
CAS
SubPathwayInteraction108425
SubPathway108425Reaction
SubPathwayReaction
PYRUVATE
BioCyc
QH2
BioCyc
SubPathwayInteraction108426
SubPathway108426Reaction
SubPathwayReaction
SubPathwayInteraction108427
SubPathway108427Reaction
SubPathwayReaction
SubPathwayInteraction108428
SubPathway108428Reaction
SubPathwayReaction
1.0
58-64-0
CAS
GTP
BioCyc
585-84-2
CAS
C00091
KEGG Compound
SubPathwayInteraction108432
SubPathway108432Reaction
SubPathwayReaction
HMDB0001273
HMDB
Isocitric acid
SubPathwayInteraction108430
SubPathwayReaction
SubPathway108430Reaction
SubPathwayInteraction108431
SubPathway108431Reaction
SubPathwayReaction
444493
PubChem-compound
Succinic acid
SubPathwayInput
ACETYL-COA
BioCyc
H2O
Water
18.010565
FADH2
BioCyc
Succinic acid
HMDB0000193
HMDB
Hydrogen carbonate
HMDB0000072
HMDB
NADH
BioCyc
NAD
BioCyc
Transport340
false
Pyruvic acid (→) Transport: Rattus norvegicus, Cell, Cytosol to Rattus norvegicus, Cell, Mitochondrial Matrix
LEFT_TO_RIGHT
HMDB0059597
HMDB
Aconitate hydratase, mitochondrial
749
ChemSpider
71-52-3
CAS
970
PubChem-compound
CIS-ACONITATE
BioCyc
SMILES
OC(=O)\C=C\C(O)=O
Acetyl-CoA
SubPathwayOutput
SubPathwayInput
Succinate dehydrogenase complex subunit C
146-91-8
CAS
C4H6O5
L-Malic acid
134.02153
CHO3
Hydrogen carbonate
60.99257
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
446013
PubChem-compound
C4H4O5
Oxalacetic acid
132.00587
L-Malic acid
Adenosine triphosphate
1.0
Valine, Leucine, and Isoleucine Degradation
SubPathway
Oxidation of Branched-Chain Fatty Acids
SubPathway
21883788
PubChem-compound
Citric acid
SMILES
O
CIT
BioCyc
Guanosine triphosphate
Lysine Degradation
SubPathway
Q99NA5
UniProt
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
HMDB0000538
HMDB
(C5H8)nC14H20O4
QH2
P14408
UniProt
P70577
UniProt
1.0
6816
PubChem-compound
328-42-7
CAS
51
PubChem-compound
1.0
Glycolysis
SubPathway
SMILES
O[C@@H](CC(O)=O)C(O)=O
SMILES
OC([O-])=O
1.0
CHEBI:15846
ChEBI
ADP
BioCyc
C3H4O3
Pyruvic acid
88.016045
CHEBI:46245
ChEBI
1.0
C6H8O7
Isocitric acid
192.02701
1038
PubChem-compound
GO:0005829
GENE ONTOLOGY
Alanine Metabolism
SubPathway
Fatty Acid Metabolism
SubPathway
274
ChemSpider
Citrate synthase, mitochondrial
C5H6O5
Oxoglutaric acid
146.02153
393487
ChemSpider
Citric acid
Urea Cycle
SubPathway
CHEBI:16908
ChEBI
2-Ketoglutarate Dehydrogenase Complex Deficiency
O4P
Phosphate
94.95342
6830
PubChem-compound
77-92-9
CAS
558863
ChemSpider
Aspartate Metabolism
SubPathway
ReactionCatalysis2569
ACTIVATION
Tryptophan Metabolism
SubPathway
1.0
Pyruvate Metabolism
SubPathway
Mitochondrion
60.0
TransportCatalysis286
ACTIVATION
643757
PubChem-compound
HMDB0000208
HMDB
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
58-68-4
CAS
SMP0000040
SMPDB
HMDB0001423
HMDB
Pyruvate carboxylase, mitochondrial
Water
SMILES
[O-]P([O-])([O-])=O
HMDB0001304
HMDB
SMILES
OC(=O)CCC(=O)C(O)=O
124-38-9
CAS
CHEBI:30915
ChEBI
Guanosine diphosphate
Mitochondrial Electron Transport Chain
SubPathway
1.0
HMDB0001429
HMDB
SMP0000051
SMPDB
HMDB0000223
HMDB
GO:0005759
GENE ONTOLOGY
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
1.0
Malate-Aspartate Shuttle
SubPathway
SMP0000059
SMPDB
Isocitrate dehydrogenase
1.0
Gluconeogenesis
SubPathway
C4H4O4
Fumaric acid
116.010956
Tyrosine Metabolism
SubPathway
Glucose-Alanine Cycle
SubPathway
SMP0000055
SMPDB
CHEBI:15741
ChEBI
SMILES
O=C=O
4444052
ChemSpider
1110
PubChem-compound
Hydrogen Ion
1.0
Q4KLP0
UniProt
HMDB0001201
HMDB
HMDB0000595
HMDB
SMP0000060
SMPDB
C21H29N7O14P2
NADH
665.12476
5280344
PubChem-compound
HMDB0001206
HMDB
5957
PubChem-compound
GO:0005743
GENE ONTOLOGY
SMP0000067
SMPDB
Propanoate Metabolism
SubPathway
C4H6O4
Succinic acid
118.02661
SMP0000063
SMPDB
C6H6O6
cis-Aconitic acid
174.01643
320-77-4
CAS
threo-d(s)-iso-citrate
BioCyc
Pyruvate dehydrogenase complex
Isocitric acid
CHEBI:15996
ChEBI
SMP0000072
SMPDB
HMDB0000243
HMDB
GO:0005739
GENE ONTOLOGY
Arginine and Proline Metabolism
SubPathway
SMP0000071
SMPDB
SMILES
OC(C(CC(O)=O)C(O)=O)C(O)=O
C10H15N5O10P2
Adenosine diphosphate
427.02942
1.0
1.0
C6H8O7
Citric acid
192.02701
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
1.0
SMP0000128
SMPDB
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
SMP0000129
SMPDB
SMP0000006
SMPDB
SMP0000127
SMPDB
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
CPD-8587
BioCyc
10116
TAXONOMY
19782904
PubChem-compound
1.0
SMILES
COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(\C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O
5682
ChemSpider
CHEBI:1146900
ChEBI
Oxalacetic acid
SubPathwayOutput
SubPathwayInput
1.0
Q3B7V7
UniProt
Mitochondrial Matrix
60.0
1.0
Fumarate hydratase, mitochondrial
Succinate-CoA ligase subunit beta
CO-A
BioCyc
CHEBI:17877
ChEBI
SMP0000016
SMPDB
222656
PubChem-compound
Fumaric acid
72-89-9
CAS
1078
ChemSpider
C21H36N7O16P3S
Coenzyme A
767.11523
Q0QEZ3
UniProt
ReactionCatalysis137158
ACTIVATION
ReactionCatalysis137159
ACTIVATION
CHEBI:15422
ChEBI
ReactionCatalysis137154
ACTIVATION
ReactionCatalysis137155
ACTIVATION
6557
ChemSpider
1.0
ReactionCatalysis137157
ACTIVATION
643975
PubChem-compound
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
Q6PCT8
UniProt
388299
ChemSpider
127-17-3
CAS
Coenzyme Q10
ReactionCatalysis137150
ACTIVATION
ReactionCatalysis137151
ACTIVATION
ReactionCatalysis137152
ACTIVATION
ReactionCatalysis137153
ACTIVATION
SMP0000020
SMPDB
CHEBI:16526
ChEBI
Q499V7
UniProt
8977
PubChem-compound
CHEBI:16761
ChEBI
SMP0000037
SMPDB
SMP0000032
SMPDB
SMP0000030
SMPDB
PW122093
PathWhiz
PW000023
PathWhiz
CHEBI:17544
ChEBI
PW000142
PathWhiz
PW000149
PathWhiz
PW000028
PathWhiz
2-KETOGLUTARATE
BioCyc
392413
ChemSpider
1.0
PW000146
PathWhiz
Oxoglutaric acid
SubPathwayOutput
SubPathwayInput
8630
ChemSpider
5893
PubChem-compound
110-15-6
CAS
1.0
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
CHEBI:32816
ChEBI
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
QH2
CHEBI:15377
ChEBI
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
CHEBI:15378
ChEBI
SMILES
[H+]
PW000010
PathWhiz
6569
ChemSpider
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
CHEBI:17552
ChEBI
280
PubChem-compound
CHEBI:30744
ChEBI
CHEBI:32805
ChEBI
1.0
PW000002
PathWhiz
PW000001
PathWhiz
Citrate synthase, mitochondrial
2.0
1.0
2.0
C00417
KEGG Compound
PW000003
PathWhiz
1.0
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
1198
PubChem-compound
Unknown
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
FAD
BioCyc
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
193317
ChemSpider
3-METHYLBENZYLSUCCINYL-COA
BioCyc
86-01-1
CAS
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Citrate synthase, mitochondrial
1060
PubChem-compound
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
1.0
1061
PubChem-compound
1.0
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
HMDB0001967
HMDB
1.0
CHEBI:15351
ChEBI
2.0
Mitochondrial pyruvate carrier 1
P63031
UniProt
SMP0120832
SMPDB
Q6P6V3
UniProt
SMP0000355
SMPDB
85-61-0
CAS
Fumarate hydratase, mitochondrial
UBIQUINONE-10
BioCyc
Dihydrolipoyl dehydrogenase, mitochondrial