Reference/HMDB HMDB0061362
type: UnificationXref
id: HMDB0061362
db: HMDB

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

direct_interaction
type: InteractionVocabulary

Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 3
type: ProteinReference
xref: Reference/UniProt Q91YW5
organism: Mus musculus

Ras-GEF domain-containing family member 1B
type: Protein
cellular location: Cytoplasm
entity reference: Ras-GEF domain-containing family member 1B

Disabled homolog 2-interacting protein
type: Protein
cellular location: Cytoplasm
entity reference: Disabled homolog 2-interacting protein

Reference/UniProt Q6P1G1
type: UnificationXref
id: Q6P1G1
db: UniProt

Signal transducer and activator of transcription 3
type: Protein
cellular location: Cytoplasm
entity reference: Signal transducer and activator of transcription 3

Reference/UniProt Q01279
type: UnificationXref
id: Q01279
db: UniProt

phosphatidylinositol 4,5-diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097074

Signal transducer and activator of transcription 1
type: Protein
cellular location: Nucleus
entity reference: Signal transducer and activator of transcription 1

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Dual specificity mitogen-activated protein kinase kinase 4
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 4

Reference/UniProt P01101
type: UnificationXref
id: P01101
db: UniProt

Mitogen-activated protein kinase 10
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 10

Mitogen-activated protein kinase 10
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 10

Endophilin-A3
type: Protein
cellular location: Cytoplasm
entity reference: Endophilin-A3

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Pro-epidermal growth factor
type: Protein
cellular location: Cell Membrane
entity reference: Pro-epidermal growth factor

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/14209 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Epidermal growth factor receptor

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine triphosphate

Guanosine 3',5'-bis(diphosphate)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17633
xref: Reference/ChemSpider 388557
xref: Reference/KEGG Compound C01228
xref: Reference/PubChem-compound 439450
xref: Reference/HMDB HMDB0059638
chemical formula: C10H17N5O17P4
molecular weight: 602.957
structure: ChemicalStructure/PW C040075

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P20444
organism: Mus musculus

Signal transducer and activator of transcription 1
type: ProteinReference
xref: Reference/UniProt P42225
organism: Mus musculus

phosphatidylinositol 4,5-diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: phosphatidylinositol 4,5-diphosphate

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Signal transducer and activator of transcription 3
type: ProteinReference
xref: Reference/UniProt B7ZC17
organism: Mus musculus

1,2-diacylglycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 1,2-diacylglycerol

Reference/UniProt Q8R0X4
type: UnificationXref
id: Q8R0X4
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Pro-epidermal growth factor
type: ProteinReference
xref: Reference/UniProt Q6P9J2
organism: Mus musculus

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/14209 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Epidermal growth factor receptor

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt F2Z441
organism: Mus musculus

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Serum response factor
type: ProteinReference
xref: Reference/UniProt Q9JM73
organism: Mus musculus

Reference/ChemSpider 388557
type: UnificationXref
id: 388557
db: ChemSpider

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Casein kinase II subunit alpha
type: Protein
cellular location: Nucleus
entity reference: Casein kinase II subunit alpha

Reference/UniProt B7ZC17
type: UnificationXref
id: B7ZC17
db: UniProt

Epidermal growth factor receptor
type: Protein
cellular location: Cytoplasm
entity reference: Epidermal growth factor receptor

Reference/SMPDB SMP0120900
type: UnificationXref
id: SMP0120900
db: SMPDB

Mitogen-activated protein kinase 10
type: ProteinReference
xref: Reference/UniProt Q9R0U6
organism: Mus musculus

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inositol 1,4,5-trisphosphate

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Casein kinase II subunit alpha
type: ProteinReference
xref: Reference/UniProt Q8R0X4
organism: Mus musculus

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt P05627
organism: Mus musculus

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Epidermal growth factor receptor
type: ProteinReference
xref: Reference/UniProt Q01279
organism: Mus musculus

Tyrosine-protein kinase JAK1
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase JAK1

Reference/UniProt Q8R2F1
type: UnificationXref
id: Q8R2F1
db: UniProt

Reaction179018
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097074 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040682 Cytoplasm/Stoichiometry/1.0
right: 1,2-diacylglycerol
spontaneous: false
left: phosphatidylinositol 4,5-diphosphate
name: phosphatidylinositol 4,5-diphosphate → 1,2-diacylglycerol
conversion direction: LEFT_TO_RIGHT

Reaction179019
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097074 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: phosphatidylinositol 4,5-diphosphate
name: phosphatidylinositol 4,5-diphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

FOS,JUN Complex
type: Complex
cellular location: Nucleus
component: Transcription factor AP-1
component: Proto-oncogene c-Fos

Reference/UniProt Q8JZL7
type: UnificationXref
id: Q8JZL7
db: UniProt

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/UniProt Q9QUU8
type: UnificationXref
id: Q9QUU8
db: UniProt

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

ChemicalStructure/PW C040682
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC(CO)OC(C)=O

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

Signal transducer and activator of transcription 2
type: Protein
cellular location: Nucleus
entity reference: Signal transducer and activator of transcription 2

Reference/KEGG Compound C01228
type: UnificationXref
id: C01228
db: KEGG Compound

Guanosine 3',5'-bis(diphosphate)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine 3',5'-bis(diphosphate)

Reference/UniProt Q62421
type: UnificationXref
id: Q62421
db: UniProt

Serum response factor
type: Protein
cellular location: Nucleus
entity reference: Serum response factor

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt Q6P1G1
organism: Mus musculus

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/PathWhiz PW122163
type: UnificationXref
id: PW122163
db: PathWhiz

Mitogen-activated protein kinase 3
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 3

ETS domain-containing protein Elk-1
type: Protein
cellular location: Nucleus
entity reference: ETS domain-containing protein Elk-1

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Signal transducer and activator of transcription 3
type: Protein
cellular location: Nucleus
entity reference: Signal transducer and activator of transcription 3

Reference/HMDB HMDB0059638
type: UnificationXref
id: HMDB0059638
db: HMDB

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Epidermal growth factor receptor
type: Protein
cellular location: Cell Membrane
entity reference: Epidermal growth factor receptor

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/UniProt Q9JM73
type: UnificationXref
id: Q9JM73
db: UniProt

1,2-diacylglycerol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061362
chemical formula: C7H12O5
molecular weight: 176.06847
structure: ChemicalStructure/PW C040682

Protein/14209 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Epidermal growth factor receptor
stoichiometric coefficient: 2.0

Reference/UniProt Q811B9
type: UnificationXref
id: Q811B9
db: UniProt

ETS domain-containing protein Elk-1
type: Protein
cellular location: Cytoplasm
entity reference: ETS domain-containing protein Elk-1

Signal transducer and activator of transcription 1
type: Protein
cellular location: Cytoplasm
entity reference: Signal transducer and activator of transcription 1

Disabled homolog 2-interacting protein
type: ProteinReference
xref: Reference/UniProt Q80T97
organism: Mus musculus

Reference/UniProt Q8CAM5
type: UnificationXref
id: Q8CAM5
db: UniProt

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

Reference/UniProt P31938
type: UnificationXref
id: P31938
db: UniProt

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Proto-oncogene c-Fos
type: ProteinReference
xref: Reference/UniProt P01101
organism: Mus musculus

Interaction1727
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma_1 activates phosphatidylinositol 4,5-diphosphate
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
participant: phosphatidylinositol 4,5-diphosphate

Interaction1726
type: MolecularInteraction
interaction type: direct_interaction
name: pro-epidermal growth factor activates Epidermal growth factor receptor
participant: Pro-epidermal growth factor
participant: Epidermal growth factor receptor

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: Reference/UniProt Q62126
organism: Mus musculus

Signal transducer and transcription activator 6
type: ProteinReference
xref: Reference/UniProt Q8R2F1
organism: Mus musculus

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Interaction1729
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates ETS domain-containing protein Elk_1
participant: ETS domain-containing protein Elk-1
participant: Protein kinase C complex

Interaction1728
type: MolecularInteraction
interaction type: direct_interaction
name: 1,2-diacylglycerol activates Protein kinase C complex
participant: 1,2-diacylglycerol
participant: Protein kinase C complex

ChemicalStructure/PW C040075
type: ChemicalStructure
structure format: SMILES

ETS domain-containing protein Elk-1
type: ProteinReference
xref: Reference/UniProt Q3V1M9
organism: Mus musculus

Reference/ChEBI CHEBI 17633
type: UnificationXref
id: CHEBI:17633
db: ChEBI

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Signal transducer and transcription activator 6
type: Protein
cellular location: Nucleus
entity reference: Signal transducer and transcription activator 6

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Ras-related protein Rab-36
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related protein Rab-36

Reference/UniProt F2Z441
type: UnificationXref
id: F2Z441
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/UniProt Q80T97
type: UnificationXref
id: Q80T97
db: UniProt

GTPase HRas
type: ProteinReference
xref: Reference/UniProt Q811B9
organism: Mus musculus

Reference/UniProt Q9R0U6
type: UnificationXref
id: Q9R0U6
db: UniProt

Interaction1741
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 4 activates Mitogen-activated protein kinase 8 without Magnesium
participant: Dual specificity mitogen-activated protein kinase kinase 4
participant: Mitogen-activated protein kinase 10

Interaction1740
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 4
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Dual specificity mitogen-activated protein kinase kinase 4

Reference/UniProt Q3V1M9
type: UnificationXref
id: Q3V1M9
db: UniProt

Mitogen-activated protein kinase 3
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 3

Interaction637
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Calcium
participant: Inositol 1,4,5-trisphosphate
participant: Calcium

Interaction1745
type: MolecularInteraction
interaction type: direct_interaction
name: Casein kinase II subunit alpha activates Serum response factor
participant: Casein kinase II subunit alpha
participant: Serum response factor

Interaction1744
type: MolecularInteraction
interaction type: direct_interaction
name: ETS domain-containing protein Elk_1 activates FOS,JUN Complex
participant: FOS,JUN Complex
participant: ETS domain-containing protein Elk-1

Interaction1743
type: MolecularInteraction
interaction type: direct_interaction
name: Signal transducer and activator of transcription 3 activates STATs
participant: Signal transducer and activator of transcription 3
participant: STATs

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Interaction1742
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex
participant: FOS,JUN Complex
participant: Mitogen-activated protein kinase 10

Interaction1749
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Son of sevenless homolog 1
participant: Ras-GEF domain-containing family member 1B
participant: Epidermal growth factor receptor

Reference/PubChem-compound 439450
type: UnificationXref
id: 439450
db: PubChem-compound

Interaction1748
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates SHC-transforming protein 1
participant: Epidermal growth factor receptor
participant: Unknown

Interaction1747
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Growth factor receptor-bound protein 2
participant: Epidermal growth factor receptor
participant: Endophilin-A3

Interaction1746
type: MolecularInteraction
interaction type: direct_interaction
name: Ras GTPase-activating protein 1 activates GTPase HRas with GDP, Phosphate
participant: Disabled homolog 2-interacting protein
participant: GTPase HRas

Reference/UniProt Q9R256
type: UnificationXref
id: Q9R256
db: UniProt

Reference/UniProt Q91YW5
type: UnificationXref
id: Q91YW5
db: UniProt

Unknown
type: ProteinReference
organism: Mus musculus

Interaction1730
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 3 activates ETS domain-containing protein Elk_1
participant: Mitogen-activated protein kinase 3
participant: ETS domain-containing protein Elk-1

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Interaction1734
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate
participant: Ras-related protein Rab-36
participant: GTPase HRas

Interaction1733
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 3
participant: Signal transducer and activator of transcription 3
participant: Tyrosine-protein kinase JAK1

Interaction1732
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 1-alpha/beta
participant: Signal transducer and activator of transcription 1
participant: Tyrosine-protein kinase JAK1

Interaction1731
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Tyrosine-protein kinase JAK1
participant: Epidermal growth factor receptor
participant: Tyrosine-protein kinase JAK1

Interaction1738
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 1
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Dual specificity mitogen-activated protein kinase kinase 1

Interaction1737
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase without zinc activates Dual specificity mitogen-activated protein kinase kinase 1
participant: Dual specificity mitogen-activated protein kinase kinase 1
participant: RAF proto-oncogene serine/threonine-protein kinase

Interaction1736
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Ras-related protein Rab-36

ChemicalStructure/PW C097074
type: ChemicalStructure
structure format: SMILES

Interaction1735
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase without zinc
participant: Ras-related protein Rab-36
participant: RAF proto-oncogene serine/threonine-protein kinase

Reaction110971
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040075 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
right: Guanosine 3',5'-bis(diphosphate)
spontaneous: false
left: Guanosine triphosphate
name: Guanosine triphosphate → Guanosine 3',5'-bis(diphosphate)
conversion direction: LEFT_TO_RIGHT

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q9R256
organism: Mus musculus

Reference/UniProt Q64250
type: UnificationXref
id: Q64250
db: UniProt

Interaction1739
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3
participant: Dual specificity mitogen-activated protein kinase kinase 1
participant: Mitogen-activated protein kinase 3

Endophilin-A3
type: ProteinReference
xref: Reference/UniProt Q62421
organism: Mus musculus

Compound/PW C040075 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine 3',5'-bis(diphosphate)
stoichiometric coefficient: 1.0

Reference/UniProt Q6P9J2
type: UnificationXref
id: Q6P9J2
db: UniProt

Reference/UniProt Q62126
type: UnificationXref
id: Q62126
db: UniProt

Ras-related protein Rab-36
type: ProteinReference
xref: Reference/UniProt Q8CAM5
organism: Mus musculus

Signal transducer and activator of transcription 2
type: ProteinReference
xref: Reference/UniProt Q64250
organism: Mus musculus

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Reference/UniProt P20444
type: UnificationXref
id: P20444
db: UniProt

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

Reference/UniProt P47809
type: UnificationXref
id: P47809
db: UniProt

Protein/14209 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Epidermal growth factor receptor
stoichiometric coefficient: 2.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Ras-GEF domain-containing family member 1B
type: ProteinReference
xref: Reference/UniProt Q8JZL7
organism: Mus musculus

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Interaction1751
type: MolecularInteraction
interaction type: direct_interaction
name: Son of sevenless homolog 1 activates Guanosine triphosphate
participant: Ras-GEF domain-containing family member 1B
participant: Guanosine triphosphate

Interaction1750
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Ras GTPase-activating protein 1
participant: Epidermal growth factor receptor
participant: Disabled homolog 2-interacting protein

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: Reference/UniProt P47809
organism: Mus musculus

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

Proto-oncogene c-Fos
type: Protein
cellular location: Nucleus
entity reference: Proto-oncogene c-Fos

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C beta type
component: Protein kinase C alpha type

STATs
type: Complex
cellular location: Nucleus
component: Signal transducer and activator of transcription 2
component: Signal transducer and activator of transcription 3
component: Signal transducer and transcription activator 6
component: Signal transducer and activator of transcription 1

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt Q9QUU8
organism: Mus musculus

Reference/UniProt P05627
type: UnificationXref
id: P05627
db: UniProt

Compound/PW C097074 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: phosphatidylinositol 4,5-diphosphate
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: Reference/UniProt P31938
organism: Mus musculus

Compound/PW C040682 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-diacylglycerol
stoichiometric coefficient: 1.0

Reference/UniProt P42225
type: UnificationXref
id: P42225
db: UniProt

EGF Signalling Pathway
type: Pathway
pathway order: PathwayInteraction/1729
pathway order: PathwayInteraction/1727
pathway order: PathwayInteraction/1749
pathway order: PathwayInteraction/1728
pathway order: PathwayInteraction/1747
pathway order: PathwayInteraction/1726
pathway order: PathwayInteraction/1748
pathway order: PathwayInteraction/1745
pathway order: PathwayInteraction/1746
pathway order: PathwayInteraction/1743
pathway order: PathwayInteraction/1744
pathway order: PathwayInteraction/1741
pathway order: PathwayInteraction/1742
pathway order: PathwayInteraction/1740
pathway order: PathwayInteraction/637
pathway order: PathwayInteraction/1738
pathway order: PathwayInteraction/1739
pathway order: PathwayInteraction/1736
pathway order: PathwayInteraction/1737
pathway order: PathwayInteraction/1734
pathway order: PathwayInteraction/1735
pathway order: PathwayInteraction/1732
pathway order: PathwayInteraction/1733
pathway order: PathwayInteraction/1730
pathway order: PathwayInteraction/1731
pathway order: PathwayEnzymeReaction/2119684
pathway order: PathwayInteraction/1750
pathway order: PathwayEnzymeReaction/2119683
pathway order: PathwayInteraction/1751
pathway order: PathwayEnzymeReaction/2119685
pathway component: Interaction1741
pathway component: Interaction1740
pathway component: Interaction637
pathway component: Interaction1745
pathway component: Interaction1744
pathway component: Interaction1743
pathway component: Interaction1742
pathway component: Interaction1727
pathway component: Interaction1749
pathway component: Interaction1726
pathway component: Interaction1748
pathway component: Interaction1747
pathway component: Interaction1746
pathway component: Interaction1729
pathway component: Interaction1728
pathway component: Reaction179018
pathway component: Reaction179019
pathway component: Interaction1730
pathway component: Interaction1751
pathway component: Interaction1750
pathway component: Interaction1734
pathway component: Interaction1733
pathway component: Interaction1732
pathway component: Interaction1731
pathway component: Interaction1738
pathway component: Interaction1737
pathway component: Interaction1736
pathway component: Interaction1735
pathway component: Reaction110971
pathway component: Interaction1739
xref: Reference/SMPDB SMP0120900
xref: Reference/PathWhiz PW122163
organism: Mus musculus