Compound/PW C104585 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Reaction109915
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
right: Malonyl-CoA
spontaneous: false
left: Acetyl-CoA
name: Acetyl-CoA → Malonyl-CoA
conversion direction: LEFT_TO_RIGHT

TransportCatalysis1447
type: Catalysis
controller: Tricarboxylate transport protein, mitochondrial
controlled: Transport10245
control type: ACTIVATION

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Compound/Generic25 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 446013
type: UnificationXref
id: 446013
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

NF-kappa-B essential modulator
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B essential modulator

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Reference/PubChem-compound 31348
type: UnificationXref
id: 31348
db: PubChem-compound

direct_interaction
type: InteractionVocabulary

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

ATP-dependent 6-phosphofructokinase, platelet type
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: ATP-dependent 6-phosphofructokinase, platelet type

Protein/20024 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B essential modulator
stoichiometric coefficient: 1.0

Protein/13636 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Malate dehydrogenase, cytoplasmic
stoichiometric coefficient: 2.0

2-Hydroxybutanedioate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 160434
chemical formula: C4H4O5
molecular weight: 132.00697
structure: ChemicalStructure/PW C104588

Hydrogen ion
type: SmallMoleculeReference
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C041026

Lipopolysaccharide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11970143
chemical formula: C205H366N3O117P5
molecular weight: 4897.147
structure: ChemicalStructure/PW C104587

2-Oxobutanedioate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 164550
chemical formula: C4H2O5
molecular weight: 129.99022
structure: ChemicalStructure/PW C104584

Citrate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 31348
chemical formula: C6H5O7
molecular weight: 189.00352
structure: ChemicalStructure/PW C104585

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

Acetyl Coenzyme A
type: SmallMoleculeReference
xref: Reference/PubChem-compound 444493
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C104583

Citrate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9CZU6
organism: Mus musculus

Reference/HMDB HMDB0001197
type: UnificationXref
id: HMDB0001197
db: HMDB

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Toll-like receptor 4
type: Protein
cellular location: Extracellular Space
entity reference: Toll-like receptor 4

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChEBI CHEBI 16238
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Citrate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Citrate

NFKB1,NFKBIA,RELA Complex with Phosphate
type: Complex
cellular location: Nucleus
component: Transcription factor p65
component: Nuclear factor NF-kappa-B p105 subunit
component: NF-kappa-B inhibitor alpha

Protein/19504 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inhibitor of nuclear factor kappa-B kinase subunit alpha
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

NF-kappa-B essential modulator
type: ProteinReference
xref: Reference/UniProt Q924H4
organism: Mus musculus

Tricarboxylate transport protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3TDH6

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8K2B3
organism: Mus musculus

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9CQA3
organism: Mus musculus

Reference/UniProt Q9D2X3
type: UnificationXref
id: Q9D2X3
db: UniProt

Reference/ChemSpider 393487
type: UnificationXref
id: 393487
db: ChemSpider

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9CXV1
organism: Mus musculus

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9CZB0
organism: Mus musculus

Reference/UniProt Q9CXV1
type: UnificationXref
id: Q9CXV1
db: UniProt

FADH
type: SmallMoleculeReference
xref: Reference/PubChem-compound 446013
xref: Reference/ChEBI CHEBI 17877
xref: Reference/BioCyc FADH2
xref: Reference/KEGG Compound C01352
xref: Reference/ChemSpider 393487
xref: Reference/HMDB HMDB0001197
xref: Reference/CAS 1910-41-4
chemical formula: C27H35N9O15P2
molecular weight: 787.1728
structure: ChemicalStructure/PW C000932

NADP-dependent malic enzyme
type: Complex
component stoichiometry: Protein/7725 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Unknown

Protein/22102 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myeloid differentiation primary response protein MyD88
stoichiometric coefficient: 1.0

ReactionCatalysis169012
type: Catalysis
controller: NADP-dependent malic enzyme
controlled: Reaction179054
control type: ACTIVATION

ReactionCatalysis169011
type: Catalysis
controller: Malate dehydrogenase, cytoplasmic
controlled: Reaction179053
control type: ACTIVATION

CHUK-IKBKB-IKBKG complex
type: Complex
component stoichiometry: Protein/19508 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/20024 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19504 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Inhibitor of nuclear factor kappa-B kinase subunit alpha
component: Inhibitor of nuclear factor kappa-B kinase subunit beta
component: NF-kappa-B essential modulator

Compound/PW C104584 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxobutanedioate
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Fatty Acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Fatty Acid

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA

Reference/UniProt Q8C712
type: UnificationXref
id: Q8C712
db: UniProt

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B inhibitor alpha

Protein/19508 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inhibitor of nuclear factor kappa-B kinase subunit beta
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

ATP-dependent 6-phosphofructokinase, platelet type
type: ProteinReference
xref: Reference/UniProt Q9WUA3
organism: Mus musculus

Protein/22097 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll/interleukin-1 receptor domain-containing adapter protein
stoichiometric coefficient: 1.0

ReactionCatalysis169009
type: Catalysis
controller: ATP-citrate synthase
controlled: Reaction179051
control type: ACTIVATION

ReactionCatalysis169008
type: Catalysis
controller: Succinate dehydrogenase
controlled: Reaction179050
control type: ACTIVATION

ReactionCatalysis169007
type: Catalysis
controller: Citrate synthase, mitochondrial
controlled: Reaction179049
control type: ACTIVATION

Protein/7725 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/UniProt Q9WUA3
type: UnificationXref
id: Q9WUA3
db: UniProt

Transport10245
type: Transport
participant stoichiometry: Compound/PW C104585 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Citrate
spontaneous: false
left: Citrate
name: Citrate (→) Transport: Mus musculus, Cell, Mitochondrial Inner Membrane to Mus musculus, Cell, Mitochondrial Outer Membrane
conversion direction: LEFT_TO_RIGHT

Protein/13609 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrate synthase, mitochondrial
stoichiometric coefficient: 2.0

Reference/UniProt P14152
type: UnificationXref
id: P14152
db: UniProt

ChemicalStructure/PW C104584
type: ChemicalStructure
structure format: SMILES
structure data: [O-]C(=O)CC(=O)C([O-])=O

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C104583
type: ChemicalStructure
structure format: SMILES

NFKB1,NFKBIA,RELA Complex with Phosphate
type: Complex
cellular location: Cytoplasm
component: Nuclear factor NF-kappa-B p105 subunit
component: Transcription factor p65
component: NF-kappa-B inhibitor alpha

Monocyte differentiation antigen CD14
type: ProteinReference
xref: Reference/UniProt P10810
organism: Mus musculus

ChemicalStructure/PW C104585
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

Protein/13618 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

ChemicalStructure/PW C104588
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC([O-])=O)C([O-])=O

Reference/PathWhiz PW122185
type: UnificationXref
id: PW122185
db: PathWhiz

ChemicalStructure/PW C104587
type: ChemicalStructure
structure format: SMILES

Lymphocyte antigen 96
type: ProteinReference
xref: Reference/UniProt Q9JHF9
organism: Mus musculus

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/ChemSpider 559059
type: UnificationXref
id: 559059
db: ChemSpider

ChemicalStructure/PW C000932
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9R1J6
type: UnificationXref
id: Q9R1J6
db: UniProt

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/CAS 1910-41-4
type: UnificationXref
id: 1910-41-4
db: CAS

Reference/ChEBI CHEBI 35366
type: UnificationXref
id: CHEBI:35366
db: ChEBI

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

TNF receptor-associated factor 6
type: Protein
cellular location: Cytoplasm
entity reference: TNF receptor-associated factor 6

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Protein/13621 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

2-Hydroxybutanedioate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2-Hydroxybutanedioate

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/UniProt P10810
type: UnificationXref
id: P10810
db: UniProt

Reaction179049
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104583 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104584 Mitochondrion/Stoichiometry/1.0
right: Citrate
spontaneous: false
left: Acetyl Coenzyme A
left: 2-Oxobutanedioate
name: 2-Oxobutanedioate + Acetyl Coenzyme A → Citrate
conversion direction: LEFT_TO_RIGHT

FAD
type: SmallMoleculeReference
xref: Reference/CAS 146-14-5
xref: Reference/HMDB HMDB0001248
xref: Reference/ChEBI CHEBI 16238
xref: Reference/BioCyc FAD
xref: Reference/PubChem-compound 643975
xref: Reference/ChemSpider 559059
xref: Reference/KEGG Compound C00016
chemical formula: C27H33N9O15P2
molecular weight: 785.1571
structure: ChemicalStructure/PW C000964

Reference/UniProt Q9CZU6
type: UnificationXref
id: Q9CZU6
db: UniProt

Reference/KEGG Compound C00016
type: UnificationXref
id: C00016
db: KEGG Compound

FAD
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: FAD

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Acetyl Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl Coenzyme A

Reference/PubChem-compound 164550
type: UnificationXref
id: 164550
db: PubChem-compound

Reaction179050
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000932 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000964 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: FADH
spontaneous: false
left: FAD
name: FAD → FADH
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/13621 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13618 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13619 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13620 Mitochondrial Inner Membrane/Stoichiometry/1.0
cellular location: Mitochondrial Inner Membrane
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Protein/13620 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

FADH
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: FADH

Compound/PW C104585 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cytoplasm
entity reference: Monocyte differentiation antigen CD14

Malate dehydrogenase, cytoplasmic
type: Complex
component stoichiometry: Protein/13636 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Malate dehydrogenase, cytoplasmic

Malonyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Malonyl-CoA

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/KEGG Compound C01352
type: UnificationXref
id: C01352
db: KEGG Compound

Transcription factor p65
type: Protein
cellular location: Cytoplasm
entity reference: Transcription factor p65

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Toll/interleukin-1 receptor domain-containing adapter protein
type: ProteinReference
xref: Reference/UniProt Q91ZW0
organism: Mus musculus

2-Oxobutanedioate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-Oxobutanedioate

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p105 subunit

Hydrogen ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen ion

ChemicalStructure/PW C000964
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q8BLV2
type: UnificationXref
id: Q8BLV2
db: UniProt

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/UniProt Q9CQA3
type: UnificationXref
id: Q9CQA3
db: UniProt

Transcription factor p65
type: Protein
cellular location: Nucleus
entity reference: Transcription factor p65

Compound/PW C000932 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: FADH
stoichiometric coefficient: 1.0

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

LPS Receptor Complex
type: Complex
cellular location: Extracellular Space
component: Monocyte differentiation antigen CD14
component: Toll-like receptor 4
component: Lymphocyte antigen 96

Citrate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Citrate

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt Q9Z203
organism: Mus musculus

ReactionCatalysis100214
type: Catalysis
controller: Unknown
controlled: Reaction109915
control type: ACTIVATION

Citrate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Citrate

Lipopolysaccharide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lipopolysaccharide

Reference/UniProt Q91ZW0
type: UnificationXref
id: Q91ZW0
db: UniProt

Reference/ChEBI CHEBI 17877
type: UnificationXref
id: CHEBI:17877
db: ChEBI

Reaction179054
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104588 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: 2-Hydroxybutanedioate
name: 2-Hydroxybutanedioate → Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reaction179053
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104588 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104584 Cytoplasm/Stoichiometry/1.0
right: 2-Hydroxybutanedioate
spontaneous: false
left: 2-Oxobutanedioate
name: 2-Oxobutanedioate → 2-Hydroxybutanedioate
conversion direction: LEFT_TO_RIGHT

Reaction179052
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104584 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Cytoplasm/Stoichiometry/1.0
right: 2-Oxobutanedioate
spontaneous: false
left: Citrate
name: Citrate → 2-Oxobutanedioate
conversion direction: LEFT_TO_RIGHT

Reaction179051
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104585 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: Acetyl-CoA
spontaneous: false
left: Citrate
name: Citrate → Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reaction179055
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: NADP
spontaneous: false
left: NADPH
name: NADPH → NADP
conversion direction: LEFT_TO_RIGHT

Compound/PW C104588 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hydroxybutanedioate
stoichiometric coefficient: 1.0

Reaction164136
type: BiochemicalReaction
participant stoichiometry: Compound/Generic25 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
right: Fatty Acid
spontaneous: false
left: Malonyl-CoA
name: Malonyl-CoA → Fatty Acid
conversion direction: LEFT_TO_RIGHT

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/UniProt Q924H4
type: UnificationXref
id: Q924H4
db: UniProt

Myeloid differentiation primary response protein MyD88 (Mus musculus)_Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus)_TNF receptor-associated factor 6 (Mus musculus)
type: Complex
component stoichiometry: Protein/22097 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21885 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22102 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Myeloid differentiation primary response protein MyD88
component: Toll/interleukin-1 receptor domain-containing adapter protein
component: TNF receptor-associated factor 6

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/UniProt Q9Z203
type: UnificationXref
id: Q9Z203
db: UniProt

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Citrate synthase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Citrate synthase, mitochondrial

Compound/PW C104585 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Protein/21885 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TNF receptor-associated factor 6
stoichiometric coefficient: 1.0

Reference/PubChem-compound 643975
type: UnificationXref
id: 643975
db: PubChem-compound

Reference/PubChem-compound 160434
type: UnificationXref
id: 160434
db: PubChem-compound

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

2-Oxobutanedioate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2-Oxobutanedioate

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Reference/SMPDB SMP0120922
type: UnificationXref
id: SMP0120922
db: SMPDB

Compound/PW C104583 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl Coenzyme A
stoichiometric coefficient: 1.0

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/HMDB HMDB0001248
type: UnificationXref
id: HMDB0001248
db: HMDB

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Nucleus
entity reference: NF-kappa-B inhibitor alpha

Reference/UniProt Q3TDH6
type: UnificationXref
id: Q3TDH6
db: UniProt

Reference/UniProt O35916
type: UnificationXref
id: O35916
db: UniProt

Reaction164141
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041026 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Hydrogen ion
right: NADPH
spontaneous: false
left: Pyruvic acid
name: Pyruvic acid → Hydrogen ion + NADPH
conversion direction: LEFT_TO_RIGHT

LPS Receptor Complex
type: Complex
cellular location: Cytoplasm
component: Monocyte differentiation antigen CD14
component: Toll-like receptor 4
component: Lymphocyte antigen 96

Reaction164142
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: NADP
name: NADP → Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C041026 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen ion
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference
organism: Mus musculus

Protein/13619 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

TNF receptor-associated factor 6
type: ProteinReference
xref: Reference/UniProt Q8BLV2
organism: Mus musculus

Citrate synthase, mitochondrial
type: Complex
component stoichiometry: Protein/13609 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Citrate synthase, mitochondrial

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/UniProt Q9WUM5
type: UnificationXref
id: Q9WUM5
db: UniProt

Reference/UniProt Q80ZX5
type: UnificationXref
id: Q80ZX5
db: UniProt

Toll/interleukin-1 receptor domain-containing adapter protein
type: Protein
cellular location: Cytoplasm
entity reference: Toll/interleukin-1 receptor domain-containing adapter protein

Reference/UniProt Q9CZB0
type: UnificationXref
id: Q9CZB0
db: UniProt

Tricarboxylate transport protein, mitochondrial
type: Protein
entity reference: Tricarboxylate transport protein, mitochondrial

Compound/PW C000964 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Fatty Acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 35366

Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt Q9JHF9
type: UnificationXref
id: Q9JHF9
db: UniProt

Monocyte differentiation antigen CD14
type: Protein
cellular location: Extracellular Space
entity reference: Monocyte differentiation antigen CD14

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt O35916
organism: Mus musculus

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P14152
organism: Mus musculus

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9WUM5
organism: Mus musculus

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt Q9R1J6
organism: Mus musculus

Reference/CAS 146-14-5
type: UnificationXref
id: 146-14-5
db: CAS

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

Reference/UniProt Q8K2B3
type: UnificationXref
id: Q8K2B3
db: UniProt

LPS and Citrate Signaling and Inflammation
type: Pathway
pathway order: PathwayInteraction/2072
pathway order: PathwayEnzymeReaction/2120119
pathway order: PathwayInteraction/2073
pathway order: PathwayEnzymeReaction/2120118
pathway order: PathwayInteraction/2070
pathway order: PathwayEnzymeReaction/2120117
pathway order: PathwayInteraction/2071
pathway order: PathwayEnzymeReaction/2120116
pathway order: PathwayEnzymeReaction/2120115
pathway order: PathwayEnzymeReaction/2120125
pathway order: PathwayEnzymeReaction/2120124
pathway order: PathwayEnzymeReaction/2120123
pathway order: PathwayEnzymeReaction/2120122
pathway order: PathwayEnzymeReaction/2120121
pathway order: PathwayEnzymeReaction/2120120
pathway order: PathwayInteraction/2069
pathway order: PathwayInteraction/2068
pathway order: PathwayInteraction/2074
pathway order: PathwayTransport/2120126
pathway component: Interaction2071
pathway component: Interaction2072
pathway component: Reaction179049
pathway component: Reaction109915
pathway component: TransportCatalysis1447
pathway component: Interaction2073
pathway component: Interaction2074
pathway component: ReactionCatalysis169009
pathway component: ReactionCatalysis169008
pathway component: ReactionCatalysis169007
pathway component: Interaction2070
pathway component: Transport10245
pathway component: Reaction179050
pathway component: Reaction164141
pathway component: Reaction164142
pathway component: ReactionCatalysis100214
pathway component: Reaction179054
pathway component: Interaction2068
pathway component: Reaction179053
pathway component: Interaction2069
pathway component: Reaction179052
pathway component: Reaction179051
pathway component: ReactionCatalysis169012
pathway component: ReactionCatalysis169011
pathway component: Reaction179055
pathway component: Reaction164136
xref: Reference/SMPDB SMP0120922
xref: Reference/PathWhiz PW122185
organism: Mus musculus

Lymphocyte antigen 96
type: Protein
cellular location: Extracellular Space
entity reference: Lymphocyte antigen 96

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor NF-kappa-B p105 subunit

Compound/PW C104584 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxobutanedioate
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9D2X3
organism: Mus musculus

Interaction2071
type: MolecularInteraction
interaction type: direct_interaction
name: Myeloid differentiation primary response protein MyD88 (Mus musculus) + Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus) + TNF receptor-associated factor 6 (Mus musculus) activates LPS Receptor Complex
participant: Myeloid differentiation primary response protein MyD88 (Mus musculus)_Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus)_TNF receptor-associated factor 6 (Mus musculus)
participant: LPS Receptor Complex

Interaction2072
type: MolecularInteraction
interaction type: direct_interaction
name: LPS Receptor Complex activates CHUK-IKBKB-IKBKG complex
participant: CHUK-IKBKB-IKBKG complex
participant: LPS Receptor Complex

Interaction2073
type: MolecularInteraction
interaction type: direct_interaction
name: CHUK-IKBKB-IKBKG complex activates NFKB1,NFKBIA,RELA Complex with Phosphate
participant: CHUK-IKBKB-IKBKG complex
participant: NFKB1,NFKBIA,RELA Complex with Phosphate

Interaction2074
type: MolecularInteraction
interaction type: direct_interaction
name: NFKB1,NFKBIA,RELA Complex with Phosphate activates Nuclear factor NF-kappa-B p105 subunit
participant: Nuclear factor NF-kappa-B p105 subunit
participant: NFKB1,NFKBIA,RELA Complex with Phosphate

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Malate dehydrogenase, cytoplasmic

Interaction2070
type: MolecularInteraction
interaction type: direct_interaction
name: Lipopolysaccharide activates LPS Receptor Complex
participant: Lipopolysaccharide
participant: LPS Receptor Complex

Reference/UniProt Q62025
type: UnificationXref
id: Q62025
db: UniProt

ATP-citrate synthase
type: Complex
component stoichiometry: Protein/13885 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Protein/13885 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
stoichiometric coefficient: 4.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/BioCyc FAD
type: UnificationXref
id: FAD
db: BioCyc

Reference/BioCyc FADH2
type: UnificationXref
id: FADH2
db: BioCyc

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: Reference/UniProt Q80ZX5
organism: Mus musculus

Lymphocyte antigen 96
type: Protein
cellular location: Cytoplasm
entity reference: Lymphocyte antigen 96

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt Q8C712
organism: Mus musculus

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

ChemicalStructure/PW C041026
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C104585 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Interaction2068
type: MolecularInteraction
interaction type: direct_interaction
name: Citrate inhibits 6-phosphofructokinase, muscle type
participant: ATP-dependent 6-phosphofructokinase, platelet type
participant: Citrate

Interaction2069
type: MolecularInteraction
interaction type: direct_interaction
name: Citrate inhibits Succinate dehydrogenase
participant: Succinate dehydrogenase
participant: Citrate

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 11970143
type: UnificationXref
id: 11970143
db: PubChem-compound

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Transcription factor p65
type: ProteinReference
xref: Reference/UniProt Q62025
organism: Mus musculus

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Citrate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Citrate