Reference/HMDB HMDB0061362
type: UnificationXref
id: HMDB0061362
db: HMDB

Interaction2097
type: MolecularInteraction
interaction type: direct_interaction
name: pro-epidermal growth factor activates Epidermal growth factor receptor
participant: Low-density lipoprotein receptor
participant: Epidermal growth factor receptor

Interaction2098
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma_1 activates phosphatidylinositol 4,5-diphosphate
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
participant: phosphatidylinositol 4,5-diphosphate

Interaction2099
type: MolecularInteraction
interaction type: direct_interaction
name: 1,2-diacylglycerol activates Protein kinase C complex
participant: 1,2-diacylglycerol
participant: Protein kinase C complex

direct_interaction
type: InteractionVocabulary

Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q2KIC2
type: UnificationXref
id: Q2KIC2
db: UniProt

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/UniProt P09851
type: UnificationXref
id: P09851
db: UniProt

Reference/UniProt P61635
type: UnificationXref
id: P61635
db: UniProt

Reference/UniProt Q7YRP7
type: UnificationXref
id: Q7YRP7
db: UniProt

Mitogen-activated protein kinase 13
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 13

STATs
type: Complex
cellular location: Nucleus
component: Signal transducer and activator of transcription 3
component: Signal transducer and activator of transcription 5A

phosphatidylinositol 4,5-diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097074

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 1

Aurora kinase A
type: Protein
cellular location: Cytoplasm
entity reference: Aurora kinase A

Serum response factor
type: Protein
cellular location: Nucleus
entity reference: Serum response factor

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Rap guanine nucleotide exchange factor 2
type: ProteinReference
xref: Reference/UniProt F1MSG6
organism: Bos taurus

Reference/UniProt Q2KI05
type: UnificationXref
id: Q2KI05
db: UniProt

Reference/UniProt Q9TUM1
type: UnificationXref
id: Q9TUM1
db: UniProt

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine triphosphate

Reference/UniProt E1BJP4
type: UnificationXref
id: E1BJP4
db: UniProt

Reference/UniProt A6QLK6
type: UnificationXref
id: A6QLK6
db: UniProt

Guanosine 3',5'-bis(diphosphate)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17633
xref: Reference/ChemSpider 388557
xref: Reference/KEGG Compound C01228
xref: Reference/PubChem-compound 439450
xref: Reference/HMDB HMDB0059638
chemical formula: C10H17N5O17P4
molecular weight: 602.957
structure: ChemicalStructure/PW C040075

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P04409
organism: Bos taurus

Serum response factor
type: ProteinReference
xref: Reference/UniProt E1BJP4
organism: Bos taurus

phosphatidylinositol 4,5-diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: phosphatidylinositol 4,5-diphosphate

Low-density lipoprotein receptor
type: ProteinReference
xref: Reference/UniProt F1MZ58
organism: Bos taurus

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Signal transducer and activator of transcription 3
type: ProteinReference
xref: Reference/UniProt P61635
organism: Bos taurus

1,2-diacylglycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 1,2-diacylglycerol

Mitogen-activated protein kinase 13
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 13

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/ChemSpider 388557
type: UnificationXref
id: 388557
db: ChemSpider

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Protein/19587 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Activated CDC42 kinase 1
stoichiometric coefficient: 2.0

Reference/PathWhiz PW122187
type: UnificationXref
id: PW122187
db: PathWhiz

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inositol 1,4,5-trisphosphate

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Mitogen-activated protein kinase 13
type: ProteinReference
xref: Reference/UniProt Q3T0N5
organism: Bos taurus

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/UniProt F1MZ58
type: UnificationXref
id: F1MZ58
db: UniProt

ETS translocation variant 1
type: Protein
cellular location: Cytoplasm
entity reference: ETS translocation variant 1

Reference/UniProt Q3T0N5
type: UnificationXref
id: Q3T0N5
db: UniProt

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt O77627
organism: Bos taurus

Activated CDC42 kinase 1
type: ProteinReference
xref: Reference/UniProt O02742
organism: Bos taurus

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

ChemicalStructure/PW C040682
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC(CO)OC(C)=O

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/19587 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Activated CDC42 kinase 1

Reference/KEGG Compound C01228
type: UnificationXref
id: C01228
db: KEGG Compound

Guanosine 3',5'-bis(diphosphate)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine 3',5'-bis(diphosphate)

Reference/UniProt O77627
type: UnificationXref
id: O77627
db: UniProt

Reference/UniProt A7YY51
type: UnificationXref
id: A7YY51
db: UniProt

Interaction2112
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 4 activates Mitogen-activated protein kinase 8 without Magnesium
participant: Mitogen-activated protein kinase 13
participant: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2113
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex
participant: Mitogen-activated protein kinase 13
participant: FOS,JUN Complex

Interaction2114
type: MolecularInteraction
interaction type: direct_interaction
name: Signal transducer and activator of transcription 3 activates STATs
participant: Signal transducer and activator of transcription 3
participant: STATs

Reference/UniProt Q3T0M4
type: UnificationXref
id: Q3T0M4
db: UniProt

Interaction2115
type: MolecularInteraction
interaction type: direct_interaction
name: ETS domain-containing protein Elk_1 activates FOS,JUN Complex
participant: ETS translocation variant 1
participant: FOS,JUN Complex

Interaction2110
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3
participant: Mitogen-activated protein kinase 1
participant: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2111
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 4
participant: Aurora kinase A
participant: Dual specificity mitogen-activated protein kinase kinase 6

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt P08487
organism: Bos taurus

Casein kinase II subunit alpha
type: Protein
cellular location: Nucleus
entity reference: Casein kinase II subunit alpha

Interaction2116
type: MolecularInteraction
interaction type: direct_interaction
name: Casein kinase II subunit alpha activates Serum response factor
participant: Serum response factor
participant: Casein kinase II subunit alpha

SHC-transforming protein 1
type: Protein
cellular location: Cytoplasm
entity reference: SHC-transforming protein 1

Interaction2117
type: MolecularInteraction
interaction type: direct_interaction
name: Ras GTPase-activating protein 1 activates GTPase HRas with GDP, Phosphate
participant: Ras GTPase-activating protein 1
participant: Ras-related protein Rap-1b

Interaction2118
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Growth factor receptor-bound protein 2
participant: Epidermal growth factor receptor
participant: GRB2-related adapter protein

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Interaction2119
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates SHC-transforming protein 1
participant: Epidermal growth factor receptor
participant: SHC-transforming protein 1

GRB2-related adapter protein
type: Protein
cellular location: Cytoplasm
entity reference: GRB2-related adapter protein

Protein/19587 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Activated CDC42 kinase 1
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Ras-related protein Rap-1b
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related protein Rap-1b

Interaction2101
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 3 activates ETS domain-containing protein Elk_1
participant: ETS translocation variant 1
participant: Mitogen-activated protein kinase 1

Interaction2102
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Tyrosine-protein kinase JAK1
participant: Epidermal growth factor receptor
participant: Activated CDC42 kinase 1

Interaction2103
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 1-alpha/beta
participant: Activated CDC42 kinase 1
participant: Signal transducer and activator of transcription 3

Interaction2104
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 3
participant: Activated CDC42 kinase 1
participant: Signal transducer and activator of transcription 3

Reference/HMDB HMDB0059638
type: UnificationXref
id: HMDB0059638
db: HMDB

Interaction2100
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates ETS domain-containing protein Elk_1
participant: Protein kinase C complex
participant: ETS translocation variant 1

Interaction2109
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 1
participant: Aurora kinase A
participant: Dual specificity mitogen-activated protein kinase kinase 6

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Signal transducer and activator of transcription 5A
type: Protein
cellular location: Nucleus
entity reference: Signal transducer and activator of transcription 5A

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Interaction2105
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate
participant: Ras-related protein Rap-1b

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt A5D7N0
organism: Bos taurus

Interaction2106
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase without zinc
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Ras-related protein Rap-1b

Interaction2107
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Ras-related protein Rap-1b
participant: Aurora kinase A

Interaction2108
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase without zinc activates Dual specificity mitogen-activated protein kinase kinase 1
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Dual specificity mitogen-activated protein kinase kinase 6

1,2-diacylglycerol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061362
chemical formula: C7H12O5
molecular weight: 176.06847
structure: ChemicalStructure/PW C040682

Activated CDC42 kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Activated CDC42 kinase 1

Reference/UniProt A5D7N0
type: UnificationXref
id: A5D7N0
db: UniProt

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Reference/UniProt Q45KX9
type: UnificationXref
id: Q45KX9
db: UniProt

Ras GTPase-activating protein 1
type: ProteinReference
xref: Reference/UniProt P09851
organism: Bos taurus

Reference/UniProt A2VE60
type: UnificationXref
id: A2VE60
db: UniProt

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt A2VE60
organism: Bos taurus

Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

ETS translocation variant 1
type: Protein
cellular location: Nucleus
entity reference: ETS translocation variant 1

Proto-oncogene c-Fos
type: ProteinReference
xref: Reference/UniProt Q7YRP7
organism: Bos taurus

ChemicalStructure/PW C040075
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17633
type: UnificationXref
id: CHEBI:17633
db: ChEBI

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

Low-density lipoprotein receptor
type: Protein
cellular location: Cell Membrane
entity reference: Low-density lipoprotein receptor

Reference/UniProt P08487
type: UnificationXref
id: P08487
db: UniProt

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reaction179057
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097074 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: phosphatidylinositol 4,5-diphosphate
name: phosphatidylinositol 4,5-diphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Interaction2120
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Son of sevenless homolog 1
participant: Epidermal growth factor receptor
participant: Rap guanine nucleotide exchange factor 2

Reaction179056
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097074 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040682 Cytoplasm/Stoichiometry/1.0
right: 1,2-diacylglycerol
spontaneous: false
left: phosphatidylinositol 4,5-diphosphate
name: phosphatidylinositol 4,5-diphosphate → 1,2-diacylglycerol
conversion direction: LEFT_TO_RIGHT

Interaction2121
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Ras GTPase-activating protein 1
participant: Epidermal growth factor receptor
participant: Ras GTPase-activating protein 1

Interaction2122
type: MolecularInteraction
interaction type: direct_interaction
name: Son of sevenless homolog 1 activates Guanosine triphosphate
participant: Rap guanine nucleotide exchange factor 2
participant: Guanosine triphosphate

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Activated CDC42 kinase 1
type: Protein
cellular location: Cell Membrane
entity reference: Activated CDC42 kinase 1

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

ETS translocation variant 1
type: ProteinReference
xref: Reference/UniProt Q2KIC2
organism: Bos taurus

SHC-transforming protein 1
type: ProteinReference
xref: Reference/UniProt Q45KX9
organism: Bos taurus

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cytoplasm
entity reference: Rap guanine nucleotide exchange factor 2

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C alpha type
component: Protein kinase C beta type

Proto-oncogene c-Fos
type: Protein
cellular location: Nucleus
entity reference: Proto-oncogene c-Fos

Reference/UniProt O02742
type: UnificationXref
id: O02742
db: UniProt

Interaction637
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Calcium
participant: Inositol 1,4,5-trisphosphate
participant: Calcium

Reference/SMPDB SMP0120924
type: UnificationXref
id: SMP0120924
db: SMPDB

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Reference/PubChem-compound 439450
type: UnificationXref
id: 439450
db: PubChem-compound

Ras-related protein Rap-1b
type: ProteinReference
xref: Reference/UniProt Q3T0M4
organism: Bos taurus

FOS,JUN Complex
type: Complex
cellular location: Nucleus
component: Transcription factor AP-1
component: Proto-oncogene c-Fos

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Casein kinase II subunit alpha
type: ProteinReference
xref: Reference/UniProt Q2KI05
organism: Bos taurus

ChemicalStructure/PW C097074
type: ChemicalStructure
structure format: SMILES

Reaction110971
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040075 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
right: Guanosine 3',5'-bis(diphosphate)
spontaneous: false
left: Guanosine triphosphate
name: Guanosine triphosphate → Guanosine 3',5'-bis(diphosphate)
conversion direction: LEFT_TO_RIGHT

Aurora kinase A
type: ProteinReference
xref: Reference/UniProt Q2TA06
organism: Bos taurus

Reference/UniProt F1MSG6
type: UnificationXref
id: F1MSG6
db: UniProt

Mitogen-activated protein kinase 1
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 1

Compound/PW C040075 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine 3',5'-bis(diphosphate)
stoichiometric coefficient: 1.0

Ras GTPase-activating protein 1
type: Protein
cellular location: Cytoplasm
entity reference: Ras GTPase-activating protein 1

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Signal transducer and activator of transcription 3
type: Protein
cellular location: Nucleus
entity reference: Signal transducer and activator of transcription 3

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/19587 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Activated CDC42 kinase 1

EGF Signalling Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2120166
pathway order: PathwayEnzymeReaction/2120165
pathway order: PathwayEnzymeReaction/2120164
pathway order: PathwayInteraction/2119
pathway order: PathwayInteraction/2117
pathway order: PathwayInteraction/2118
pathway order: PathwayInteraction/2115
pathway order: PathwayInteraction/2116
pathway order: PathwayInteraction/2113
pathway order: PathwayInteraction/2114
pathway order: PathwayInteraction/2111
pathway order: PathwayInteraction/2112
pathway order: PathwayInteraction/2098
pathway order: PathwayInteraction/2099
pathway order: PathwayInteraction/2110
pathway order: PathwayInteraction/2097
pathway order: PathwayInteraction/637
pathway order: PathwayInteraction/2108
pathway order: PathwayInteraction/2109
pathway order: PathwayInteraction/2106
pathway order: PathwayInteraction/2107
pathway order: PathwayInteraction/2104
pathway order: PathwayInteraction/2105
pathway order: PathwayInteraction/2102
pathway order: PathwayInteraction/2103
pathway order: PathwayInteraction/2100
pathway order: PathwayInteraction/2122
pathway order: PathwayInteraction/2101
pathway order: PathwayInteraction/2120
pathway order: PathwayInteraction/2121
pathway component: Interaction2112
pathway component: Interaction2113
pathway component: Interaction2114
pathway component: Interaction2115
pathway component: Interaction2097
pathway component: Interaction2098
pathway component: Interaction2099
pathway component: Interaction2110
pathway component: Interaction637
pathway component: Interaction2111
pathway component: Interaction2116
pathway component: Interaction2117
pathway component: Interaction2118
pathway component: Interaction2119
pathway component: Interaction2101
pathway component: Interaction2102
pathway component: Interaction2103
pathway component: Interaction2104
pathway component: Reaction179057
pathway component: Interaction2120
pathway component: Reaction179056
pathway component: Interaction2121
pathway component: Interaction2100
pathway component: Interaction2122
pathway component: Interaction2109
pathway component: Interaction2105
pathway component: Interaction2106
pathway component: Interaction2107
pathway component: Interaction2108
pathway component: Reaction110971
xref: Reference/SMPDB SMP0120924
xref: Reference/PathWhiz PW122187
organism: Bos taurus

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/UniProt P04409
type: UnificationXref
id: P04409
db: UniProt

GRB2-related adapter protein
type: ProteinReference
xref: Reference/UniProt A6QLK6
organism: Bos taurus

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q5E9X2
type: UnificationXref
id: Q5E9X2
db: UniProt

Signal transducer and activator of transcription 3
type: Protein
cellular location: Cytoplasm
entity reference: Signal transducer and activator of transcription 3

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Compound/PW C097074 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: phosphatidylinositol 4,5-diphosphate
stoichiometric coefficient: 1.0

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt A7YY51
organism: Bos taurus

Reference/UniProt Q2TA06
type: UnificationXref
id: Q2TA06
db: UniProt

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: Reference/UniProt Q9TUM1
organism: Bos taurus

Compound/PW C040682 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-diacylglycerol
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt Q5E9X2
organism: Bos taurus