Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Interaction2090
type: MolecularInteraction
interaction type: direct_interaction
name: Growth factor receptor-bound protein 2 activates Son of sevenless homolog 1
participant: Rap guanine nucleotide exchange factor 2
participant: GRB2-related adapter protein

Cyclic AMP-dependent transcription factor ATF-4
type: ProteinReference
xref: Reference/UniProt Q3ZCH6
organism: Bos taurus

Unknown
type: Protein
cellular location: Membrane
entity reference: Unknown

direct_interaction
type: InteractionVocabulary

Gonadoliberin
type: Protein
cellular location: Cell Membrane
entity reference: Gonadoliberin

Reference/UniProt Q29W20
type: UnificationXref
id: Q29W20
db: UniProt

Protein/19407 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Bos taurus)
type: Complex
component stoichiometry: Protein/19407 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Phosphate
component: Dual specificity mitogen-activated protein kinase kinase 6

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Reference/UniProt Q2KJE6
type: UnificationXref
id: Q2KJE6
db: UniProt

Reference/UniProt Q2KIC2
type: UnificationXref
id: Q2KIC2
db: UniProt

Reference/UniProt P04837
type: UnificationXref
id: P04837
db: UniProt

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q7M2U0
organism: Bos taurus

Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Bos taurus)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/19407 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Dual specificity mitogen-activated protein kinase kinase 6

Mitogen-activated protein kinase 13
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 13

Protein/21889 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Early growth response protein 1
stoichiometric coefficient: 1.0

Ternary complex (LRRC7, CAMK2a, ACTN4)
type: Complex
component stoichiometry: Protein/21979 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22028 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22026 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Alpha-actinin-4
component: Leucine-rich repeat-containing protein 7
component: Calcium/calmodulin-dependent protein kinase type II subunit delta

Protein/22028 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leucine-rich repeat-containing protein 7
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 1

Aurora kinase A
type: Protein
cellular location: Cytoplasm
entity reference: Aurora kinase A

Reference/UniProt Q7M2U0
type: UnificationXref
id: Q7M2U0
db: UniProt

Reference/UniProt P01217
type: UnificationXref
id: P01217
db: UniProt

Reference/UniProt A5D7D1
type: UnificationXref
id: A5D7D1
db: UniProt

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: Reference/UniProt Q2TA47
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt P10894
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Phosphate_Mitogen-activated protein kinase 1 (Bos taurus)
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19413 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase 1
component: Phosphate

Cyclic AMP-dependent transcription factor ATF-4
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-dependent transcription factor ATF-4

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/UniProt E1BIN8
type: UnificationXref
id: E1BIN8
db: UniProt

Rap guanine nucleotide exchange factor 2
type: ProteinReference
xref: Reference/UniProt F1MSG6
organism: Bos taurus

Activated CDC42 kinase 1
type: Protein
cellular location: Membrane
entity reference: Activated CDC42 kinase 1

Protein/19413 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Reference/UniProt A6QLK6
type: UnificationXref
id: A6QLK6
db: UniProt

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P04409
organism: Bos taurus

Protein/21979 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Alpha-actinin-4
stoichiometric coefficient: 1.0

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Mitogen-activated protein kinase 13
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 13

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Transport10250
type: Transport
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Bos taurus, Cell, Endoplasmic Reticulum to Bos taurus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt P19754
organism: Bos taurus

Tyrosine-protein kinase Fyn
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase Fyn

Cytosolic phospholipase A2
type: Protein
cellular location: Cytoplasm
entity reference: Cytosolic phospholipase A2

Protein/19460 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcription factor AP-1
stoichiometric coefficient: 1.0

Reference/UniProt Q2KI66
type: UnificationXref
id: Q2KI66
db: UniProt

Protein/19587 Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Activated CDC42 kinase 1
stoichiometric coefficient: 2.0

DG
type: SmallMoleculeReference

Protein/19458 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 13
stoichiometric coefficient: 1.0

Reference/PathWhiz PW122188
type: UnificationXref
id: PW122188
db: PathWhiz

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: Reference/UniProt A0JNB0
organism: Bos taurus

Heparin binding EGF like growth factor
type: Protein
cellular location: Extracellular Space
entity reference: Heparin binding EGF like growth factor

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Mitogen-activated protein kinase 13
type: ProteinReference
xref: Reference/UniProt Q3T0N5
organism: Bos taurus

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/7764 Membrane/Stoichiometry/1.0
cellular location: Membrane
component: Unknown

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Alpha-actinin-4
type: Protein
cellular location: Cytoplasm
entity reference: Alpha-actinin-4

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Mitogen-activated protein kinase 14 (Bos taurus)_Phosphate
type: Complex
component stoichiometry: Protein/19458 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase 13
component: Phosphate

Reference/UniProt Q3T0N5
type: UnificationXref
id: Q3T0N5
db: UniProt

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Heparin binding EGF like growth factor
type: ProteinReference
xref: Reference/UniProt E1BIN8
organism: Bos taurus

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt O77627
organism: Bos taurus

Gonadotropin-releasing hormone receptor
type: Protein
cellular location: Cytoplasm
entity reference: Gonadotropin-releasing hormone receptor

Protein kinase C complex
type: Complex
cellular location: Membrane
component: Protein kinase C beta type
component: Protein kinase C alpha type

Protein kinase C beta type
type: Protein
cellular location: Membrane
entity reference: Protein kinase C beta type

Activated CDC42 kinase 1
type: ProteinReference
xref: Reference/UniProt O02742
organism: Bos taurus

Protein/19409 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Phosphate_Mitogen-activated protein kinase 1 (Bos taurus)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/19413 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Mitogen-activated protein kinase 1

Heparin binding EGF like growth factor
type: Protein
cellular location: Membrane
entity reference: Heparin binding EGF like growth factor

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/19587 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Activated CDC42 kinase 1

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/UniProt O77627
type: UnificationXref
id: O77627
db: UniProt

Reference/UniProt A7YY51
type: UnificationXref
id: A7YY51
db: UniProt

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

72 kDa type IV collagenase
type: Protein
cellular location: Extracellular Space
entity reference: 72 kDa type IV collagenase

Protein/19709 Endoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Reference/UniProt Q3T0M4
type: UnificationXref
id: Q3T0M4
db: UniProt

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Calmodulin
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Interaction2118
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Growth factor receptor-bound protein 2
participant: Epidermal growth factor receptor
participant: GRB2-related adapter protein

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Protein/22026 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium/calmodulin-dependent protein kinase type II subunit delta
stoichiometric coefficient: 1.0

GRB2-related adapter protein
type: Protein
cellular location: Cytoplasm
entity reference: GRB2-related adapter protein

Protein/19587 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Activated CDC42 kinase 1
stoichiometric coefficient: 2.0

DG
type: SmallMolecule
cellular location: Cytoplasm
entity reference: DG

Protein/19458 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 13
stoichiometric coefficient: 1.0

Ras-related protein Rap-1b
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related protein Rap-1b

Matrix metalloproteinase-14
type: ProteinReference
xref: Reference/UniProt Q9GLE4
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: Protein
cellular location: Cytoplasm
entity reference: Guanine nucleotide-binding protein subunit alpha-11

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Gonadotropin-releasing hormone receptor
type: Protein
cellular location: Cell Membrane
entity reference: Gonadotropin-releasing hormone receptor

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Dual specificity mitogen-activated protein kinase kinase 3 (Bos taurus)_Phosphate
type: Complex
component stoichiometry: Protein/19407 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Phosphate
component: Dual specificity mitogen-activated protein kinase kinase 6

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt A5D7N0
organism: Bos taurus

72 kDa type IV collagenase
type: ProteinReference
xref: Reference/UniProt Q9GLE5
organism: Bos taurus

Reference/UniProt P19754
type: UnificationXref
id: P19754
db: UniProt

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Arachidonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Arachidonic acid

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Reference/UniProt Q1XD55
type: UnificationXref
id: Q1XD55
db: UniProt

Activated CDC42 kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Activated CDC42 kinase 1

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Reference/UniProt A5D7N0
type: UnificationXref
id: A5D7N0
db: UniProt

Interaction2134
type: MolecularInteraction
interaction type: direct_interaction
name: Voltage-dependent L-type calcium channel activates Protein kinase C complex
participant: Protein kinase C complex
participant: Unknown

Interaction2135
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates Voltage-depenent L-type calcium channel
participant: Protein kinase C complex
participant: Voltage-depenent L-type calcium channel

Interaction2136
type: MolecularInteraction
interaction type: direct_interaction
name: MMP2-MMP14 activates Proheparin-binding EGF-like growth factor
participant: Heparin binding EGF like growth factor
participant: MMP2-MMP14

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Interaction2137
type: MolecularInteraction
interaction type: direct_interaction
name: Proheparin-binding EGF-like growth factor activates Epidermal growth factor receptor
participant: Epidermal growth factor receptor
participant: Heparin binding EGF like growth factor

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Nucleus
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2130
type: MolecularInteraction
interaction type: direct_interaction
name: Calmodulin-like protein 6 activates Ternary complex (LRRC7, CAMK2a, ACTN4)
participant: Calmodulin
participant: Ternary complex (LRRC7, CAMK2a, ACTN4)

Alpha-actinin-4
type: ProteinReference
xref: Reference/UniProt A5D7D1
organism: Bos taurus

Leucine-rich repeat-containing protein 7
type: ProteinReference
xref: Reference/UniProt F1MCA7
organism: Bos taurus

Interaction2131
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates DG
participant: DG
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Interaction2132
type: MolecularInteraction
interaction type: direct_interaction
name: DG activates Protein kinase C complex
participant: Protein kinase C complex
participant: DG

Interaction2133
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Voltage-dependent L-type calcium channel
participant: Calcium
participant: Unknown

Reference/UniProt P00517
type: UnificationXref
id: P00517
db: UniProt

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: ProteinReference
xref: Reference/UniProt Q2HJF7
organism: Bos taurus

Phospholipase D2
type: ProteinReference
xref: Reference/UniProt Q08DV7
organism: Bos taurus

Interaction2138
type: MolecularInteraction
interaction type: direct_interaction
name: Son of sevenless homolog 1 activates GTPase HRas
participant: Ras-related protein Rap-1b
participant: Rap guanine nucleotide exchange factor 2

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/19587 Membrane/Stoichiometry/2.0
cellular location: Membrane
component: Activated CDC42 kinase 1

Interaction2139
type: MolecularInteraction
interaction type: direct_interaction
name: Cytosolic phospholipase A2 beta activates Arachidonic acid
participant: Arachidonic acid
participant: Cytosolic phospholipase A2

Reference/UniProt A2VE60
type: UnificationXref
id: A2VE60
db: UniProt

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Glycoprotein hormones alpha chain
type: ProteinReference
xref: Reference/UniProt P01217
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt A2VE60
organism: Bos taurus

IP3
type: SmallMoleculeReference

Follitropin subunit beta
type: ProteinReference
xref: Reference/UniProt P04837
organism: Bos taurus

Phosphatidic Acid
type: SmallMoleculeReference

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

ETS translocation variant 1
type: Protein
cellular location: Nucleus
entity reference: ETS translocation variant 1

Lutropin subunit beta
type: ProteinReference
xref: Reference/UniProt P04651
organism: Bos taurus

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

Phosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Phosphate

Interaction2123
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Adenylate cyclase type 1
participant: Unknown
participant: Adenylate cyclase type 1

Interaction2124
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylate cyclase type 1 activates cAMP
participant: Adenylate cyclase type 1
participant: cAMP

Interaction2125
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP

Interaction2126
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein subunit alpha-11 activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1
participant: Guanine nucleotide-binding protein subunit alpha-11
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Glycoprotein hormones alpha chain
type: Protein
cellular location: Nucleus
entity reference: Glycoprotein hormones alpha chain

Protein/7764 Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/UniProt A0JNB0
type: UnificationXref
id: A0JNB0
db: UniProt

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Interaction2127
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates IP3
participant: IP3
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Interaction2128
type: MolecularInteraction
interaction type: direct_interaction
name: IP3 activates Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate receptor type 1
participant: IP3

Leucine-rich repeat-containing protein 7
type: Protein
cellular location: Cytoplasm
entity reference: Leucine-rich repeat-containing protein 7

Gonadoliberin
type: ProteinReference
xref: Reference/UniProt Q0VBW7
organism: Bos taurus

Interaction2129
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calmodulin-like protein 6
participant: Calmodulin
participant: Calcium

Gonadotropin-releasing hormone receptor
type: ProteinReference
xref: Reference/UniProt P32236
organism: Bos taurus

ETS translocation variant 1
type: ProteinReference
xref: Reference/UniProt Q2KIC2
organism: Bos taurus

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cytoplasm
entity reference: Rap guanine nucleotide exchange factor 2

Serine/threonine-protein kinase 4
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein kinase 4

Phospholipase D2
type: Protein
cellular location: Cytoplasm
entity reference: Phospholipase D2

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C alpha type
component: Protein kinase C beta type

Interaction2150
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 2 activates Dual specificity mitogen-activated protein kinase kinase 3 (Bos taurus) + Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 3 (Bos taurus)_Phosphate
participant: Serine/threonine-protein kinase 4

Interaction2151
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 3 (Bos taurus) + Phosphate activates Mitogen-activated protein kinase 14 (Bos taurus) + Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 3 (Bos taurus)_Phosphate
participant: Mitogen-activated protein kinase 14 (Bos taurus)_Phosphate

Reference/UniProt O02742
type: UnificationXref
id: O02742
db: UniProt

Interaction2156
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Mitogen-activated protein kinase 1 (Bos taurus) activates Phosphate + Early growth response protein 1 (Bos taurus) + ELK1 (Bos taurus)
participant: Phosphate_Early growth response protein 1 (Bos taurus)_ELK1 (Bos taurus)
participant: Phosphate_Mitogen-activated protein kinase 1 (Bos taurus)

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Interaction2157
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Bos taurus) + ELK1 (Bos taurus) activates Lutropin subunit beta
participant: Phosphate_Early growth response protein 1 (Bos taurus)_ELK1 (Bos taurus)
participant: Lutropin subunit beta

Interaction2158
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Bos taurus) + ELK1 (Bos taurus) activates Glycoprotein hormones alpha chain
participant: Phosphate_Early growth response protein 1 (Bos taurus)_ELK1 (Bos taurus)
participant: Glycoprotein hormones alpha chain

Interaction2159
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Bos taurus) + ELK1 (Bos taurus) activates Follitropin subunit beta
participant: Phosphate_Early growth response protein 1 (Bos taurus)_ELK1 (Bos taurus)
participant: Follitropin subunit beta

Interaction2152
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates RAF proto-oncogene serine/threonine-protein kinase (Bos taurus) + Phosphate
participant: Protein kinase C complex
participant: RAF proto-oncogene serine/threonine-protein kinase (Bos taurus)_Phosphate

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: Protein
cellular location: Cytoplasm
entity reference: Calcium/calmodulin-dependent protein kinase type II subunit delta

Interaction2153
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase (Bos taurus) + Phosphate
participant: Ras-related protein Rap-1b
participant: RAF proto-oncogene serine/threonine-protein kinase (Bos taurus)_Phosphate

Interaction2154
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase (Bos taurus) + Phosphate activates Dual specificity mitogen-activated protein kinase kinase 1 (Bos taurus) + Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 1 (Bos taurus)_Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase (Bos taurus)_Phosphate

Phosphatidic Acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphatidic Acid

Interaction2155
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 1 (Bos taurus) + Phosphate activates Phosphate + Mitogen-activated protein kinase 1 (Bos taurus)
participant: Dual specificity mitogen-activated protein kinase kinase 1 (Bos taurus)_Phosphate
participant: Phosphate_Mitogen-activated protein kinase 1 (Bos taurus)

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Nucleus
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Ras-related protein Rap-1b
type: ProteinReference
xref: Reference/UniProt Q3T0M4
organism: Bos taurus

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Cell division control protein 42 homolog
type: ProteinReference
xref: Reference/UniProt Q2KJ93
organism: Bos taurus

Reference/SMPDB SMP0120925
type: UnificationXref
id: SMP0120925
db: SMPDB

Reference/UniProt P32236
type: UnificationXref
id: P32236
db: UniProt

Interaction2140
type: MolecularInteraction
interaction type: direct_interaction
name: Phospholipase D1 activates Phosphatidic Acid
participant: Phospholipase D2
participant: Phosphatidic Acid

Lutropin subunit beta
type: Protein
cellular location: Nucleus
entity reference: Lutropin subunit beta

Interaction2145
type: MolecularInteraction
interaction type: direct_interaction
name: Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein alpha
participant: Gonadotropin-releasing hormone receptor
participant: Unknown

Interaction2146
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP-dependent protein kinase catalytic subunit alpha activates Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus) + Phosphate
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus)_Phosphate

Interaction2147
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus) + Phosphate activates Follitropin subunit beta
participant: Follitropin subunit beta
participant: Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus)_Phosphate

Interaction2148
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus) + Phosphate activates Lutropin subunit beta
participant: Lutropin subunit beta
participant: Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus)_Phosphate

Interaction2141
type: MolecularInteraction
interaction type: direct_interaction
name: Proto-oncogene tyrosine-protein kinase Src activates Cell division control protein 42 homolog
participant: Cell division control protein 42 homolog
participant: Tyrosine-protein kinase Fyn

Interaction2142
type: MolecularInteraction
interaction type: direct_interaction
name: Cell division control protein 42 homolog activates Mitogen-activated protein kinase kinase kinase 1
participant: Cell division control protein 42 homolog
participant: Aurora kinase A

Phosphate_Mitogen-activated protein kinase 8 (Bos taurus)
type: Complex
component stoichiometry: Protein/19458 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Mitogen-activated protein kinase 13
component: Phosphate

Reference/UniProt Q2KJ93
type: UnificationXref
id: Q2KJ93
db: UniProt

Interaction2143
type: MolecularInteraction
interaction type: direct_interaction
name: Progonadoliberin-1 activates Gonadotropin-releasing hormone receptor
participant: Gonadotropin-releasing hormone receptor
participant: Gonadoliberin

Early growth response protein 1
type: ProteinReference
xref: Reference/UniProt Q29W20
organism: Bos taurus

Interaction2144
type: MolecularInteraction
interaction type: direct_interaction
name: Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein subunit alpha-11
participant: Gonadotropin-releasing hormone receptor
participant: Guanine nucleotide-binding protein subunit alpha-11

IP3
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: IP3

Reference/GENE ONTOLOGY GO 0016020
type: UnificationXref
id: GO:0016020
db: GENE ONTOLOGY

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Interaction2149
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus) + Phosphate activates Glycoprotein hormones alpha chain
participant: Glycoprotein hormones alpha chain
participant: Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus)_Phosphate

Reference/UniProt F1MSG6
type: UnificationXref
id: F1MSG6
db: UniProt

Aurora kinase A
type: ProteinReference
xref: Reference/UniProt Q2TA06
organism: Bos taurus

Mitogen-activated protein kinase 1
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 1

Cytosolic phospholipase A2
type: ProteinReference
xref: Reference/UniProt Q1XD55
organism: Bos taurus

Adenylate cyclase type 1
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 1

Cell division control protein 42 homolog
type: Protein
cellular location: Cytoplasm
entity reference: Cell division control protein 42 homolog

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

RAF proto-oncogene serine/threonine-protein kinase (Bos taurus)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19409 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: RAF proto-oncogene serine/threonine-protein kinase
component: Phosphate

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19709 Endoplasmic Reticulum/Stoichiometry/4.0
cellular location: Endoplasmic Reticulum
component: Inositol 1,4,5-trisphosphate receptor type 1

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Serine/threonine-protein kinase 4
type: ProteinReference
xref: Reference/UniProt Q2KI66
organism: Bos taurus

Reference/UniProt Q2TA47
type: UnificationXref
id: Q2TA47
db: UniProt

Protein kinase C alpha type
type: Protein
cellular location: Membrane
entity reference: Protein kinase C alpha type

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

MMP2-MMP14
type: Complex
cellular location: Extracellular Space
component: Matrix metalloproteinase-14
component: 72 kDa type IV collagenase

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Interaction2160
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 activates Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Bos taurus)
participant: Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Bos taurus)
participant: Aurora kinase A

Interaction2161
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Bos taurus) activates Phosphate + Mitogen-activated protein kinase 8 (Bos taurus)
participant: Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Bos taurus)
participant: Phosphate_Mitogen-activated protein kinase 8 (Bos taurus)

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Interaction2162
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Mitogen-activated protein kinase 8 (Bos taurus) activates Phosphate + Transcription factor AP-1 (Bos taurus)
participant: Phosphate_Transcription factor AP-1 (Bos taurus)
participant: Phosphate_Mitogen-activated protein kinase 8 (Bos taurus)

Phosphate_Transcription factor AP-1 (Bos taurus)
type: Complex
component stoichiometry: Protein/19460 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Transcription factor AP-1
component: Phosphate

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Interaction2163
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Bos taurus) activates Lutropin subunit beta
participant: Lutropin subunit beta
participant: Phosphate_Transcription factor AP-1 (Bos taurus)

Interaction2164
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Bos taurus) activates Glycoprotein hormones alpha chain
participant: Glycoprotein hormones alpha chain
participant: Phosphate_Transcription factor AP-1 (Bos taurus)

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Interaction2165
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Bos taurus) activates Follitropin subunit beta
participant: Phosphate_Transcription factor AP-1 (Bos taurus)
participant: Follitropin subunit beta

Calcium
type: SmallMolecule
cellular location: Membrane
entity reference: Calcium

Reference/UniProt F1MCA7
type: UnificationXref
id: F1MCA7
db: UniProt

Calmodulin
type: ProteinReference
xref: Reference/UniProt Q2KJE6
organism: Bos taurus

Follitropin subunit beta
type: Protein
cellular location: Nucleus
entity reference: Follitropin subunit beta

GnRH Signaling Pathway
type: Pathway
pathway order: PathwayInteraction/2160
pathway order: PathwayInteraction/2161
pathway order: PathwayInteraction/2139
pathway order: PathwayInteraction/2118
pathway order: PathwayInteraction/2137
pathway order: PathwayInteraction/2159
pathway order: PathwayInteraction/2138
pathway order: PathwayInteraction/2135
pathway order: PathwayInteraction/2157
pathway order: PathwayInteraction/2136
pathway order: PathwayInteraction/2158
pathway order: PathwayInteraction/2133
pathway order: PathwayInteraction/2155
pathway order: PathwayInteraction/2134
pathway order: PathwayInteraction/2156
pathway order: PathwayInteraction/2131
pathway order: PathwayInteraction/2153
pathway order: PathwayInteraction/2132
pathway order: PathwayInteraction/2154
pathway order: PathwayInteraction/2151
pathway order: PathwayInteraction/2130
pathway order: PathwayInteraction/2152
pathway order: PathwayInteraction/2150
pathway order: PathwayInteraction/2090
pathway order: PathwayTransport/2120194
pathway order: PathwayInteraction/2128
pathway order: PathwayInteraction/2129
pathway order: PathwayInteraction/2126
pathway order: PathwayInteraction/2148
pathway order: PathwayInteraction/2127
pathway order: PathwayInteraction/2149
pathway order: PathwayInteraction/2124
pathway order: PathwayInteraction/2146
pathway order: PathwayInteraction/2125
pathway order: PathwayInteraction/2147
pathway order: PathwayInteraction/2144
pathway order: PathwayInteraction/2123
pathway order: PathwayInteraction/2145
pathway order: PathwayInteraction/2142
pathway order: PathwayInteraction/2164
pathway order: PathwayInteraction/2143
pathway order: PathwayInteraction/2165
pathway order: PathwayInteraction/2140
pathway order: PathwayInteraction/2162
pathway order: PathwayInteraction/2141
pathway order: PathwayInteraction/2163
pathway component: Interaction2150
pathway component: Interaction2151
pathway component: Interaction2090
pathway component: Interaction2134
pathway component: Interaction2156
pathway component: Interaction2135
pathway component: Interaction2157
pathway component: Interaction2136
pathway component: Interaction2158
pathway component: Interaction2137
pathway component: Interaction2159
pathway component: Interaction2130
pathway component: Interaction2152
pathway component: Interaction2131
pathway component: Interaction2153
pathway component: Interaction2132
pathway component: Interaction2154
pathway component: Interaction2133
pathway component: Interaction2155
pathway component: Interaction2138
pathway component: Interaction2139
pathway component: Interaction2118
pathway component: Interaction2160
pathway component: Interaction2161
pathway component: Interaction2140
pathway component: Interaction2162
pathway component: Interaction2123
pathway component: Interaction2145
pathway component: Interaction2124
pathway component: Interaction2146
pathway component: Interaction2125
pathway component: Interaction2147
pathway component: Interaction2126

Reference/UniProt Q08DV7
type: UnificationXref
id: Q08DV7
db: UniProt

Reference/UniProt P04409
type: UnificationXref
id: P04409
db: UniProt

Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016020

GRB2-related adapter protein
type: ProteinReference
xref: Reference/UniProt A6QLK6
organism: Bos taurus

Reference/UniProt P10894
type: UnificationXref
id: P10894
db: UniProt

Protein/21457 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic AMP-dependent transcription factor ATF-4
stoichiometric coefficient: 1.0

Reference/UniProt P04651
type: UnificationXref
id: P04651
db: UniProt

Reference/UniProt Q9GLE5
type: UnificationXref
id: Q9GLE5
db: UniProt

Reference/UniProt Q9GLE4
type: UnificationXref
id: Q9GLE4
db: UniProt

Reference/UniProt Q5E9X2
type: UnificationXref
id: Q5E9X2
db: UniProt

Early growth response protein 1
type: Protein
cellular location: Nucleus
entity reference: Early growth response protein 1

Protein/19422 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: ETS translocation variant 1
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P00517
organism: Bos taurus

Protein/19407 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Reference/UniProt Q3ZCH6
type: UnificationXref
id: Q3ZCH6
db: UniProt

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Cyclic AMP-dependent transcription factor ATF-4 (Bos taurus)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/21457 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Cyclic AMP-dependent transcription factor ATF-4
component: Phosphate

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt A7YY51
organism: Bos taurus

Dual specificity mitogen-activated protein kinase kinase 1 (Bos taurus)_Phosphate
type: Complex
component stoichiometry: Protein/19407 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Phosphate
component: Dual specificity mitogen-activated protein kinase kinase 6

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Matrix metalloproteinase-14
type: Protein
cellular location: Extracellular Space
entity reference: Matrix metalloproteinase-14

Compound/PW C001104 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Phosphate_Early growth response protein 1 (Bos taurus)_ELK1 (Bos taurus)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/19422 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/21889 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Early growth response protein 1
component: Phosphate
component: ETS translocation variant 1

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Calcium

Reference/UniProt Q2HJF7
type: UnificationXref
id: Q2HJF7
db: UniProt

Reference/UniProt Q2TA06
type: UnificationXref
id: Q2TA06
db: UniProt

Unknown
type: ProteinReference
organism: Bos taurus

Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

IP3
type: SmallMolecule
cellular location: Cytoplasm
entity reference: IP3

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Reference/UniProt Q0VBW7
type: UnificationXref
id: Q0VBW7
db: UniProt

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Protein/19413 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt Q5E9X2
organism: Bos taurus