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Mitogen- activated protein kinase 7 Insulin-like growth factor 1 receptor Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Adenylate cyclase type 1 cAMP-dependent protein kinase catalytic subunit alpha Guanine nucleotide- binding protein subunit alpha-11 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Inositol 1,4,5- trisphosphate receptor type 1 Calmodulin Calcium/calmodulin- dependent protein kinase type II subunit delta Protein kinase C beta type Unknown Unknown Voltage- dependent L-type calcium channel subunit alpha Matrix metalloproteinase- 14 72 kDa type IV collagenase Heparin binding EGF like growth factor Activated CDC42 kinase 1 GRB2-related adapter protein Rap guanine nucleotide exchange factor 2 Ras-related protein Rap-1b Cytosolic phospholipase A2 Phospholipase D2 Tyrosine- protein kinase Fyn Cell division control protein 42 homolog Aurora kinase A Gonadoliberin Gonadotropin- releasing hormone receptor Serine/threonine- protein kinase 4 Lutropin subunit beta Glycoprotein hormones alpha chain Follitropin subunit beta Cyclic AMP-dependent transcription factor ATF-4 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 13 RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 1 Early growth response protein 1 ETS translocation variant 1 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 13 Transcription factor AP-1 cAMP Ca+ Ca+ Arachidonic acid Ca+ Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Protein kinase C alpha type IP3 DG Phosphatidic Acid Neuroactive ligand-receptor interaction Gonadotropins gene expression & secretion Indirect link or Unknown reaction cytokine-cytokine receptor interactions Indirect link or Unknown reaction Extracellular Space Cytoplasm of Pituitary gonadotrope cell Nucleus Indirect link or Unknown reaction cAMP Signaling Pathway Calcium Signaling Pathway Erk1/Erk2 Mapk Signaling Pathway
Nucleus MAPK7 IGF1R GNAS ADCY1 PRKACA GNA11 PLCB1 ITPR1 CALM CAMK2D PRKCB Unknown Unknown CACNA1C MMP14 MMP2 HBEGF TNK2 GRAP RAPGEF2 RAP1B PLA2G4A PLD2 FYN CDC42 AURKA GNRH1 GNRHR STK4 LHB CGA FSHB ATF4 MAP2K6 MAPK13 RAF1 MAP2K6 MAPK1 EGR1 ETV1 MAP2K6 MAPK13 JUN cAMP Calcium Calcium Arachidonic acid Calcium Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate PRKCA IP3 DG Phosphatidic Acid
MAPK7 IGF1R GNAS ADCY1 PRKACA GNA11 PLCB1 ITPR1 CALM CAMK2D PRKCB CACNA1C MMP14 MMP2 HBEGF TNK2 GRAP RAPGEF2 RAP1B PLA2G4A PLD2 FYN CDC42 AURKA GNRH1 GNRHR STK4 LHB CGA FSHB ATF4 MAP2K6 MAPK13 RAF1 MAP2K6 MAPK1 EGR1 ETV1 MAP2K6 MAPK13 JUN cAMP Ca+ Ca+ 20:4 Ca+ Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi PRKCA IP3 DG PA Neuroactive ligand-receptor interaction Gonadotropins gene expression & secretion Indirect link or Unknown reaction cytokine-cytokine receptor interactions Indirect link or Unknown reaction Extracellular Space Cytoplasm of Pituitary gonadotrope cell Nucleus Indirect link or Unknown reaction cAMP Signaling Pathway Calcium Signaling Pathway Erk1/Erk2 Mapk Signaling Pathway