Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Proteasome subunit beta type-2
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-2

Protein Substrates
type: Protein
entity reference: Protein Substrates

Proteasome subunit alpha type-4
type: ProteinReference
xref: Reference/UniProt Q3ZCK9
organism: Bos taurus

Proteasome subunit alpha type-3
type: ProteinReference
xref: Reference/UniProt Q58DU5
organism: Bos taurus

direct_interaction
type: InteractionVocabulary

ProteinComplex/12363/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-1
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-1

Protein/21692 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-3
stoichiometric coefficient: 1.0

Polyubiquitin-B
type: Protein
entity reference: Polyubiquitin-B

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

26S proteasome (Bos taurus)_Ubiquitin Complex (Bos taurus)_Protein Substrates
type: Complex
component stoichiometry: ProteinComplex/12361/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12363/Stoichiometry/1.0
component stoichiometry: Protein/Generic404/Stoichiometry/1.0
component: Protein Substrates
component: Ubiquitin Complex
component: 26S proteasome

Protein Substrates_Ubiquitin Complex (Bos taurus)
type: Complex
component stoichiometry: ProteinComplex/12361/Stoichiometry/1.0
component stoichiometry: Protein/Generic404/Stoichiometry/1.0
component: Protein Substrates
component: Ubiquitin Complex

Ubiquitin Complex (Bos taurus)_Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
type: Complex
component stoichiometry: ProteinComplex/12361/Stoichiometry/1.0
component stoichiometry: Protein/20959/Stoichiometry/1.0
component: Ubiquitin Complex
component: Ubiquitin-conjugating enzyme E2 E3

Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus)_Ubiquitin Complex (Bos taurus)
type: Complex
component stoichiometry: ProteinComplex/12361/Stoichiometry/1.0
component stoichiometry: Protein/20953/Stoichiometry/1.0
component: Ubiquitin-like modifier-activating enzyme 1
component: Ubiquitin Complex

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/UniProt P0CG53
type: UnificationXref
id: P0CG53
db: UniProt

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Protein/21708 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-6
stoichiometric coefficient: 1.0

Protein/21697/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-4
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Protein/21732/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-4
stoichiometric coefficient: 1.0

Protein/21703 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-5
stoichiometric coefficient: 1.0

26S proteasome non-ATPase regulatory subunit 4
type: Protein
entity reference: 26S proteasome non-ATPase regulatory subunit 4

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-6
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-6

Ubiquitin Complex
type: Complex
component: Polyubiquitin-C
component: Polyubiquitin-B

Protein/Generic404 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates
stoichiometric coefficient: 1.0

Reference/UniProt Q3MHN0
type: UnificationXref
id: Q3MHN0
db: UniProt

26S proteasome regulatory subunit 10B
type: Protein
entity reference: 26S proteasome regulatory subunit 10B

Reference/UniProt Q2T9X7
type: UnificationXref
id: Q2T9X7
db: UniProt

26S proteasome
type: Complex
component stoichiometry: Protein/21687/Stoichiometry/1.0
component stoichiometry: Protein/21703/Stoichiometry/1.0
component stoichiometry: Protein/21742/Stoichiometry/1.0
component stoichiometry: Protein/21697/Stoichiometry/1.0
component stoichiometry: Protein/21717/Stoichiometry/1.0
component stoichiometry: Protein/21755/Stoichiometry/1.0
component stoichiometry: Protein/21722/Stoichiometry/1.0
component stoichiometry: Protein/21772/Stoichiometry/1.0
component stoichiometry: Protein/21737/Stoichiometry/1.0
component stoichiometry: Protein/21732/Stoichiometry/1.0
component stoichiometry: Protein/21712/Stoichiometry/1.0
component stoichiometry: Protein/21777/Stoichiometry/1.0
component stoichiometry: Protein/21682/Stoichiometry/1.0
component stoichiometry: Protein/21708/Stoichiometry/1.0
component stoichiometry: Protein/21754/Stoichiometry/1.0
component stoichiometry: Protein/21748/Stoichiometry/1.0
component stoichiometry: Protein/21770/Stoichiometry/1.0
component stoichiometry: Protein/21692/Stoichiometry/1.0
component stoichiometry: Protein/21729/Stoichiometry/1.0
component stoichiometry: Protein/21763/Stoichiometry/1.0
component: Proteasome subunit alpha type-6
component: Proteasome subunit beta type-3
component: Proteasome subunit beta type-1
component: Proteasome subunit alpha type-7
component: Proteasome subunit beta type-2
component: 26S proteasome regulatory subunit 7
component: 26S proteasome non-ATPase regulatory subunit 4
component: Proteasome subunit beta type-4
component: 26S proteasome regulatory subunit 6B
component: Proteasome subunit alpha type-2
component: Proteasome subunit beta type-6
component: Proteasome subunit beta type-5
component: Proteasome subunit beta type-7
component: Proteasome subunit alpha type-5
component: Proteasome subunit alpha type-1
component: 26S proteasome regulatory subunit 10B
component: Proteasome subunit alpha type-3
component: Proteasome subunit alpha type-4
component: 26S proteasome regulatory subunit 8
component: 26S proteasome non-ATPase regulatory subunit 13

Reference/UniProt Q3T0Z1
type: UnificationXref
id: Q3T0Z1
db: UniProt

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Protein/21729/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-3
stoichiometric coefficient: 1.0

Protein/21763/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 8
stoichiometric coefficient: 1.0

26S proteasome non-ATPase regulatory subunit 13
type: Protein
entity reference: 26S proteasome non-ATPase regulatory subunit 13

ProteinComplex/12361/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin Complex
stoichiometric coefficient: 1.0

Reference/UniProt A3KMV5
type: UnificationXref
id: A3KMV5
db: UniProt

Protein/Generic404/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates
stoichiometric coefficient: 1.0

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

26S proteasome
type: Complex
component stoichiometry: Protein/21722 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21697 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21708 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21763 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21729 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21737 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21682 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21755 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21748 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21772 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21742 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21770 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21703 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21712 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21777 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21687 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21692 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21754 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21717 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21732 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Proteasome subunit beta type-7
component: 26S proteasome non-ATPase regulatory subunit 13
component: Proteasome subunit alpha type-5
component: 26S proteasome regulatory subunit 6B
component: Proteasome subunit alpha type-3
component: Proteasome subunit beta type-2
component: Proteasome subunit alpha type-2
component: Proteasome subunit alpha type-7
component: 26S proteasome non-ATPase regulatory subunit 4
component: Proteasome subunit alpha type-1
component: Proteasome subunit beta type-4
component: Proteasome subunit alpha type-6
component: Proteasome subunit beta type-6
component: 26S proteasome regulatory subunit 7
component: Proteasome subunit alpha type-4
component: Proteasome subunit beta type-5
component: Proteasome subunit beta type-1
component: Proteasome subunit beta type-3
component: 26S proteasome regulatory subunit 8
component: 26S proteasome regulatory subunit 10B

STIP1 homology and U-box containing protein 1
type: ProteinReference
xref: Reference/UniProt A7LCW9
organism: Bos taurus

Reference/UniProt Q3T0Y5
type: UnificationXref
id: Q3T0Y5
db: UniProt

Proteasome subunit alpha type-7
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-7

Protein/21712 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-7
stoichiometric coefficient: 1.0

Protein/21708/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-6
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

26S proteasome regulatory subunit 8
type: Protein
entity reference: 26S proteasome regulatory subunit 8

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Ubiquitin-conjugating enzyme E2 E3
type: ProteinReference
xref: Reference/UniProt Q2T9X7
organism: Bos taurus

Reference/UniProt Q3T0H8
type: UnificationXref
id: Q3T0H8
db: UniProt

Protein/21748 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-7
stoichiometric coefficient: 1.0

Ubiquitin-like modifier-activating enzyme 1
type: ProteinReference
xref: Reference/UniProt A3KMV5
organism: Bos taurus

Reference/UniProt Q3T0X5
type: UnificationXref
id: Q3T0X5
db: UniProt

Reference/UniProt Q2TBX6
type: UnificationXref
id: Q2TBX6
db: UniProt

26S proteasome regulatory subunit 7
type: Protein
entity reference: 26S proteasome regulatory subunit 7

26S proteasome regulatory subunit 6B
type: Protein
entity reference: 26S proteasome regulatory subunit 6B

Proteasome subunit beta type-4
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-4

Protein/21754 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 6B
stoichiometric coefficient: 1.0

Reference/UniProt Q3ZCK9
type: UnificationXref
id: Q3ZCK9
db: UniProt

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/UniProt P0CH28
type: UnificationXref
id: P0CH28
db: UniProt

26S proteasome non-ATPase regulatory subunit 4
type: ProteinReference
xref: Reference/UniProt Q0V8P5
organism: Bos taurus

Protein/21737 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-5
stoichiometric coefficient: 1.0

Peptide
type: Protein
entity reference: Peptide

Reference/UniProt Q2KIW6
type: UnificationXref
id: Q2KIW6
db: UniProt

Reference/UniProt Q3T108
type: UnificationXref
id: Q3T108
db: UniProt

Protein/21742 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-6
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Proteasome subunit beta type-6
type: Protein
entity reference: Proteasome subunit beta type-6

26S proteasome non-ATPase regulatory subunit 13
type: ProteinReference
xref: Reference/UniProt Q3T0Z1
organism: Bos taurus

Proteasome subunit beta type-7
type: Protein
entity reference: Proteasome subunit beta type-7

26S proteasome regulatory subunit 10B
type: ProteinReference
xref: Reference/UniProt Q2KIW6
organism: Bos taurus

26S proteasome regulatory subunit 7
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome regulatory subunit 7

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Protein/21742/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-6
stoichiometric coefficient: 1.0

Reference/UniProt A6H7C5
type: UnificationXref
id: A6H7C5
db: UniProt

Protein Substrates
type: ProteinReference
organism: Bos taurus

Protein/21712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-7
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Protein/21682/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-1
stoichiometric coefficient: 1.0

Proteasome subunit beta type-4
type: Protein
entity reference: Proteasome subunit beta type-4

Polyubiquitin-B
type: ProteinReference
xref: Reference/UniProt P0CG53
organism: Bos taurus

Proteasome subunit beta type-5
type: Protein
entity reference: Proteasome subunit beta type-5

Protein/21717 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-1
stoichiometric coefficient: 1.0

Protein/21692/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-3
stoichiometric coefficient: 1.0

Reference/PathWhiz PW122192
type: UnificationXref
id: PW122192
db: PathWhiz

26S proteasome regulatory subunit 6B
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome regulatory subunit 6B

Proteasome subunit alpha type-3
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-3

ProteinComplex/12361 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin Complex
stoichiometric coefficient: 1.0

Proteasome subunit beta type-3
type: Protein
entity reference: Proteasome subunit beta type-3

Interaction2230
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus) + Ubiquitin Complex (Bos taurus) activates Ubiquitin Complex (Bos taurus) + Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
participant: Ubiquitin Complex (Bos taurus)_Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
participant: Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus)_Ubiquitin Complex (Bos taurus)

Interaction2231
type: MolecularInteraction
interaction type: direct_interaction
name: E3 ubiquitin-protein ligase CHIP (E3) activates Ubiquitin Complex (Bos taurus) + Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
participant: STIP1 homology and U-box containing protein 1
participant: Ubiquitin Complex (Bos taurus)_Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)

Interaction2232
type: MolecularInteraction
interaction type: direct_interaction
name: Protein Substrates activates Ubiquitin Complex (Bos taurus) + Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
participant: Protein Substrates
participant: Ubiquitin Complex (Bos taurus)_Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)

Proteasome subunit beta type-2
type: Protein
entity reference: Proteasome subunit beta type-2

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

BoundComplex/422/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin Complex (Bos taurus)_Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
stoichiometric coefficient: 1.0

Protein/21763 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 8
stoichiometric coefficient: 1.0

Protein/21755/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 7
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-2
type: ProteinReference
xref: Reference/UniProt Q3T0Y5
organism: Bos taurus

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Proteasome subunit beta type-1
type: Protein
entity reference: Proteasome subunit beta type-1

Proteasome subunit alpha type-7
type: Protein
entity reference: Proteasome subunit alpha type-7

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Interaction2227
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin-like modifier-activating enzyme 1 with ATP activates Ubiquitin Complex
participant: Ubiquitin-like modifier-activating enzyme 1
participant: Ubiquitin Complex

Interaction2228
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin Complex activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus) + Ubiquitin Complex (Bos taurus)
participant: Ubiquitin Complex
participant: Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus)_Ubiquitin Complex (Bos taurus)

Proteasome subunit alpha type-1
type: ProteinReference
xref: Reference/UniProt Q3T0X5
organism: Bos taurus

Interaction2229
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin-conjugating enzyme E2 E1 activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus) + Ubiquitin Complex (Bos taurus)
participant: Ubiquitin-conjugating enzyme E2 E3
participant: Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus)_Ubiquitin Complex (Bos taurus)

Reference/UniProt A7LCW9
type: UnificationXref
id: A7LCW9
db: UniProt

Reaction179065
type: BiochemicalReaction
participant stoichiometry: Protein/20953/Stoichiometry/1.0
participant stoichiometry: BoundComplex/421/Stoichiometry/1.0
right: Ubiquitin-like modifier-activating enzyme 1
spontaneous: false
left: Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus)_Ubiquitin Complex (Bos taurus)
name: Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus) + Ubiquitin Complex (Bos taurus) → Ubiquitin-like modifier-activating enzyme 1 (E1)
conversion direction: LEFT_TO_RIGHT

Protein/21729 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-3
stoichiometric coefficient: 1.0

Reaction179064
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Protein/20953/Stoichiometry/1.0
right: Adenosine monophosphate
spontaneous: false
left: Ubiquitin-like modifier-activating enzyme 1
name: Ubiquitin-like modifier-activating enzyme 1 with ATP → Adenosine monophosphate
conversion direction: LEFT_TO_RIGHT

Proteasome subunit beta type-4
type: ProteinReference
xref: Reference/UniProt Q3T108
organism: Bos taurus

Proteasome subunit alpha type-6
type: Protein
entity reference: Proteasome subunit alpha type-6

Protein/21682 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-1
stoichiometric coefficient: 1.0

Protein/21755 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 7
stoichiometric coefficient: 1.0

Reaction179069
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/12363 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/424 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/423 Cytoplasm/Stoichiometry/1.0
right: 26S proteasome (Bos taurus)_Ubiquitin Complex (Bos taurus)_Protein Substrates
spontaneous: false
left: Protein Substrates_Ubiquitin Complex (Bos taurus)
left: 26S proteasome
name: 26S proteasome + Protein Substrates + Ubiquitin Complex (Bos taurus) → 26S proteasome (Bos taurus) + Ubiquitin Complex (Bos taurus) + Protein Substrates
conversion direction: LEFT_TO_RIGHT

Proteasome subunit beta type-5
type: ProteinReference
xref: Reference/UniProt Q32KL2
organism: Bos taurus

Reaction179068
type: BiochemicalReaction
participant stoichiometry: BoundComplex/423/Stoichiometry/1.0
right: Protein Substrates_Ubiquitin Complex (Bos taurus)
spontaneous: false
left: Protein Substrates_Ubiquitin Complex (Bos taurus)
name: Protein Substrates + Ubiquitin Complex (Bos taurus) → Protein Substrates + Ubiquitin Complex (Bos taurus)
conversion direction: LEFT_TO_RIGHT

Reaction179067
type: BiochemicalReaction
participant stoichiometry: BoundComplex/423/Stoichiometry/1.0
participant stoichiometry: BoundComplex/422/Stoichiometry/1.0
right: Protein Substrates_Ubiquitin Complex (Bos taurus)
spontaneous: false
left: Ubiquitin Complex (Bos taurus)_Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
name: Ubiquitin Complex (Bos taurus) + Ubiquitin-conjugating enzyme E2 E1 (Bos taurus) → Protein Substrates + Ubiquitin Complex (Bos taurus)
conversion direction: LEFT_TO_RIGHT

Protein/21770 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 10B
stoichiometric coefficient: 1.0

Reaction179066
type: BiochemicalReaction
participant stoichiometry: BoundComplex/422/Stoichiometry/1.0
participant stoichiometry: Protein/20959/Stoichiometry/1.0
right: Ubiquitin-conjugating enzyme E2 E3
spontaneous: false
left: Ubiquitin Complex (Bos taurus)_Ubiquitin-conjugating enzyme E2 E1 (Bos taurus)
name: Ubiquitin Complex (Bos taurus) + Ubiquitin-conjugating enzyme E2 E1 (Bos taurus) → Ubiquitin-conjugating enzyme E2 E1
conversion direction: LEFT_TO_RIGHT

Polyubiquitin-C
type: Protein
entity reference: Polyubiquitin-C

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Protein/21687 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-2
stoichiometric coefficient: 1.0

Reaction179071
type: BiochemicalReaction
participant stoichiometry: BoundComplex/424/Stoichiometry/1.0
participant stoichiometry: Protein/Generic19/Stoichiometry/1.0
right: Peptide
spontaneous: false
left: 26S proteasome (Bos taurus)_Ubiquitin Complex (Bos taurus)_Protein Substrates
name: 26S proteasome (Bos taurus) + Ubiquitin Complex (Bos taurus) + Protein Substrates → Peptide
conversion direction: LEFT_TO_RIGHT

Reaction179070
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/12361/Stoichiometry/1.0
participant stoichiometry: BoundComplex/424/Stoichiometry/1.0
right: Ubiquitin Complex
spontaneous: false
left: 26S proteasome (Bos taurus)_Ubiquitin Complex (Bos taurus)_Protein Substrates
name: 26S proteasome (Bos taurus) + Ubiquitin Complex (Bos taurus) + Protein Substrates → Ubiquitin Complex
conversion direction: LEFT_TO_RIGHT

Proteasome subunit alpha type-5
type: Protein
entity reference: Proteasome subunit alpha type-5

Polyubiquitin-B
type: Protein
cellular location: Cytoplasm
entity reference: Polyubiquitin-B

Proteasome subunit alpha type-4
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-4

Reference/UniProt Q0V8P5
type: UnificationXref
id: Q0V8P5
db: UniProt

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Protein/21687/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-2
stoichiometric coefficient: 1.0

Reference/UniProt Q5E9K0
type: UnificationXref
id: Q5E9K0
db: UniProt

Reference/UniProt Q32KL2
type: UnificationXref
id: Q32KL2
db: UniProt

BoundComplex/424 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome (Bos taurus)_Ubiquitin Complex (Bos taurus)_Protein Substrates
stoichiometric coefficient: 1.0

Protein/21722/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-2
stoichiometric coefficient: 1.0

Protein/21772/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 13
stoichiometric coefficient: 1.0

Proteasome subunit beta type-6
type: ProteinReference
xref: Reference/UniProt Q3MHN0
organism: Bos taurus

Protein/20953/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin-like modifier-activating enzyme 1
stoichiometric coefficient: 1.0

Proteasome subunit beta type-7
type: ProteinReference
xref: Reference/UniProt Q2TBP0
organism: Bos taurus

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Proteasome subunit beta type-5
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-5

Peptide
type: ProteinReference
xref: Reference/ChEBI CHEBI 16670
organism: Bos taurus

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/UniProt Q2YDE4
type: UnificationXref
id: Q2YDE4
db: UniProt

26S proteasome regulatory subunit 7
type: ProteinReference
xref: Reference/UniProt Q3T0H8
organism: Bos taurus

26S proteasome regulatory subunit 6B
type: ProteinReference
xref: Reference/UniProt Q3T030
organism: Bos taurus

Polyubiquitin-C
type: Protein
cellular location: Cytoplasm
entity reference: Polyubiquitin-C

Ubiquitin-conjugating enzyme E2 E3
type: Protein
entity reference: Ubiquitin-conjugating enzyme E2 E3

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Ubiquitin-like modifier-activating enzyme 1
type: Protein
entity reference: Ubiquitin-like modifier-activating enzyme 1

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Proteasome subunit beta type-6
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-6

Protein/21748/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-7
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0120929
type: UnificationXref
id: SMP0120929
db: SMPDB

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

26S proteasome regulatory subunit 8
type: ProteinReference
xref: Reference/UniProt A6H7C5
organism: Bos taurus

Protein/21772 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 13
stoichiometric coefficient: 1.0

Protein/Generic19/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

BoundComplex/423/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates_Ubiquitin Complex (Bos taurus)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

STIP1 homology and U-box containing protein 1
type: Protein
entity reference: STIP1 homology and U-box containing protein 1

Protein/21777 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 4
stoichiometric coefficient: 1.0

Protein Substrates
type: Protein
cellular location: Cytoplasm
entity reference: Protein Substrates

Reference/UniProt Q2TBP0
type: UnificationXref
id: Q2TBP0
db: UniProt

ProteinComplex/12363 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome
stoichiometric coefficient: 1.0

Reaction110970
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

26S proteasome regulatory subunit 10B
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome regulatory subunit 10B

Proteasome subunit beta type-7
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-7

Proteasome subunit alpha type-5
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-5

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Protein/21754/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 6B
stoichiometric coefficient: 1.0

Ubiquitin Complex
type: Complex
cellular location: Cytoplasm
component: Polyubiquitin-B
component: Polyubiquitin-C

Proteasome subunit beta type-1
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-1

26S proteasome regulatory subunit 8
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome regulatory subunit 8

Proteasome subunit alpha type-6
type: ProteinReference
xref: Reference/UniProt Q2YDE4
organism: Bos taurus

26S proteasome non-ATPase regulatory subunit 13
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome non-ATPase regulatory subunit 13

Reference/UniProt Q3T059
type: UnificationXref
id: Q3T059
db: UniProt

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

BoundComplex/421/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin-like modifier-activating enzyme 1 (E1) (Bos taurus)_Ubiquitin Complex (Bos taurus)
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-5
type: ProteinReference
xref: Reference/UniProt Q5E987
organism: Bos taurus

Polyubiquitin-C
type: ProteinReference
xref: Reference/UniProt P0CH28
organism: Bos taurus

26S proteasome (Bos taurus)_Ubiquitin Complex (Bos taurus)_Protein Substrates
type: Complex
component stoichiometry: ProteinComplex/12363 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/Generic404 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12361 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Ubiquitin Complex
component: Protein Substrates
component: 26S proteasome

Proteasome subunit alpha type-3
type: Protein
entity reference: Proteasome subunit alpha type-3

Reference/UniProt Q3ZBG0
type: UnificationXref
id: Q3ZBG0
db: UniProt

Proteasome subunit alpha type-4
type: Protein
entity reference: Proteasome subunit alpha type-4

Protein/21732 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-4
stoichiometric coefficient: 1.0

Ubiquitin–Proteasome Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2120316
pathway order: PathwayEnzymeReaction/2120315
pathway order: PathwayEnzymeReaction/2120314
pathway order: PathwayEnzymeReaction/2120313
pathway order: PathwayEnzymeReaction/2120312
pathway order: PathwayEnzymeReaction/2120311
pathway order: PathwayEnzymeReaction/2120310
pathway order: PathwayInteraction/2229
pathway order: PathwayInteraction/2227
pathway order: PathwayInteraction/2228
pathway order: PathwayInteraction/2232
pathway order: PathwayInteraction/2230
pathway order: PathwayInteraction/2231
pathway order: PathwayEnzymeReaction/2120309
pathway order: PathwayEnzymeReaction/2120308
pathway component: Reaction179065
pathway component: Reaction179064
pathway component: Reaction179069
pathway component: Reaction179068
pathway component: Interaction2230
pathway component: Reaction179067
pathway component: Interaction2231
pathway component: Reaction179066
pathway component: Interaction2232
pathway component: Reaction179071
pathway component: Interaction2227
pathway component: Reaction179070
pathway component: Interaction2228
pathway component: Interaction2229
pathway component: Reaction110970
xref: Reference/SMPDB SMP0120929
xref: Reference/PathWhiz PW122192
organism: Bos taurus

Proteasome subunit beta type-1
type: ProteinReference
xref: Reference/UniProt Q2TBX6
organism: Bos taurus

Protein/21703/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-5
stoichiometric coefficient: 1.0

Protein Substrates_Ubiquitin Complex (Bos taurus)
type: Complex
component stoichiometry: Protein/Generic404 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12361 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Ubiquitin Complex
component: Protein Substrates

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Protein/20959/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin-conjugating enzyme E2 E3
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16670
type: UnificationXref
id: CHEBI:16670
db: ChEBI

Protein/21777/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 4
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-7
type: ProteinReference
xref: Reference/UniProt Q3ZBG0
organism: Bos taurus

Proteasome subunit alpha type-2
type: Protein
entity reference: Proteasome subunit alpha type-2

Reference/UniProt Q58DU5
type: UnificationXref
id: Q58DU5
db: UniProt

Proteasome subunit alpha type-1
type: Protein
entity reference: Proteasome subunit alpha type-1

Protein/21722 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-2
stoichiometric coefficient: 1.0

Proteasome subunit beta type-3
type: ProteinReference
xref: Reference/UniProt Q3T059
organism: Bos taurus

Protein/21697 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-4
stoichiometric coefficient: 1.0

Protein/21717/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-1
stoichiometric coefficient: 1.0

Reference/UniProt Q5E987
type: UnificationXref
id: Q5E987
db: UniProt

Proteasome subunit beta type-2
type: ProteinReference
xref: Reference/UniProt Q5E9K0
organism: Bos taurus

Protein/21737/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-5
stoichiometric coefficient: 1.0

BoundComplex/424/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome (Bos taurus)_Ubiquitin Complex (Bos taurus)_Protein Substrates
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-2
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-2

Reference/UniProt Q3T030
type: UnificationXref
id: Q3T030
db: UniProt

26S proteasome non-ATPase regulatory subunit 4
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome non-ATPase regulatory subunit 4

Protein/21770/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome regulatory subunit 10B
stoichiometric coefficient: 1.0

BoundComplex/423 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates_Ubiquitin Complex (Bos taurus)
stoichiometric coefficient: 1.0

Proteasome subunit beta type-3
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-3