Reference/UniProt A7MBJ4
type: UnificationXref
id: A7MBJ4
db: UniProt

Tyrosine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

direct_interaction
type: InteractionVocabulary

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt Q2KJE6
type: UnificationXref
id: Q2KJE6
db: UniProt

T cell receptor
type: Complex
cellular location: Cytoplasm
component: Uncharacterized protein

Reference/UniProt Q2KIC2
type: UnificationXref
id: Q2KIC2
db: UniProt

Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Protein/19592 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
stoichiometric coefficient: 1.0

Antigen
type: SmallMolecule
entity reference: Antigen

Reference/UniProt Q7YRP7
type: UnificationXref
id: Q7YRP7
db: UniProt

Mitogen-activated protein kinase 13
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 13

Reference/UniProt Q309F2
type: UnificationXref
id: Q309F2
db: UniProt

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Tyrosine-protein kinase
type: ProteinReference
xref: Reference/UniProt Q32PK0
organism: Bos taurus

T cell receptor (Bos taurus)_T-cell surface glycoprotein CD3 (Bos taurus)
type: Complex
component stoichiometry: ProteinComplex/12414/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12413/Stoichiometry/1.0
component: T cell receptor
component: T-cell surface glycoprotein CD3

T cell receptor (Bos taurus)_T-cell surface glycoprotein CD3 (Bos taurus)
type: Complex
component stoichiometry: ProteinComplex/12414 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12413 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: T-cell surface glycoprotein CD3
component: T cell receptor

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 1

Aurora kinase A
type: Protein
cellular location: Cytoplasm
entity reference: Aurora kinase A

Interaction2310
type: MolecularInteraction
interaction type: direct_interaction
name: Proto-oncogene vav activates Activated Ras-related C3 botulinum toxin substrate 1
participant: Ras-related C3 botulinum toxin substrate 1
participant: Proto-oncogene vav

Interaction2311
type: MolecularInteraction
interaction type: direct_interaction
name: Activated Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Ras-related C3 botulinum toxin substrate 1
participant: Aurora kinase A

Interaction2312
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate
participant: Aurora kinase A
participant: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2313
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate activates Mitogen-activated protein kinase 8 with Phosphate
participant: Mitogen-activated protein kinase 13
participant: Dual specificity mitogen-activated protein kinase kinase 6

Reference/HMDB HMDB0015002
type: UnificationXref
id: HMDB0015002
db: HMDB

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Interaction2318
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C complex (Bos taurus) + Calcium
participant: Protein kinase C complex (Bos taurus)_Calcium
participant: Diacylglycerol

Interaction2319
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex (Bos taurus) + Calcium activates NFKB1,NFKBIA,RELA,Ub Complex with Phosphate
participant: Protein kinase C complex (Bos taurus)_Calcium
participant: NFKB1,NFKBIA,RELA,Ub Complex with Phosphate

Rap guanine nucleotide exchange factor 2
type: ProteinReference
xref: Reference/UniProt F1MSG6
organism: Bos taurus

Interaction2314
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 8 with Phosphate activates Transcription factor AP-1
participant: Transcription factor AP-1
participant: Mitogen-activated protein kinase 13

Interaction2315
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 3 with Phosphate activates Proto-oncogene c-Fos
participant: Proto-oncogene c-Fos
participant: Mitogen-activated protein kinase 1

Interaction2316
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 3 with Phosphate activates ETS domain-containing protein Elk-1
participant: Mitogen-activated protein kinase 1
participant: ETS translocation variant 1

Interaction2317
type: MolecularInteraction
interaction type: direct_interaction
name: Linker for activation of T-cells family member 1 with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 without zinc
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
participant: Linker for activation of T cells

T Cell Receptor Signaling Pathway
type: Pathway
pathway order: PathwayInteraction/2319
pathway order: PathwayInteraction/2317
pathway order: PathwayInteraction/2318
pathway order: PathwayInteraction/2315
pathway order: PathwayInteraction/2316
pathway order: PathwayInteraction/2313
pathway order: PathwayInteraction/2314
pathway order: PathwayInteraction/2311
pathway order: PathwayInteraction/2312
pathway order: PathwayInteraction/2298
pathway order: PathwayInteraction/2299
pathway order: PathwayInteraction/2310
pathway order: PathwayInteraction/2296
pathway order: PathwayInteraction/2297
pathway order: PathwayInteraction/2294
pathway order: PathwayEnzymeReaction/2120418
pathway order: PathwayInteraction/2295
pathway order: PathwayEnzymeReaction/2120417
pathway order: PathwayInteraction/2292
pathway order: PathwayEnzymeReaction/2120416
pathway order: PathwayInteraction/2293
pathway order: PathwayEnzymeReaction/2120415
pathway order: PathwayEnzymeReaction/2120414
pathway order: PathwayInteraction/2308
pathway order: PathwayInteraction/2309
pathway order: PathwayInteraction/2306
pathway order: PathwayInteraction/2307
pathway order: PathwayInteraction/2304
pathway order: PathwayInteraction/2305
pathway order: PathwayInteraction/2302
pathway order: PathwayInteraction/2324
pathway order: PathwayInteraction/2303
pathway order: PathwayInteraction/2300
pathway order: PathwayInteraction/2322
pathway order: PathwayInteraction/2301
pathway order: PathwayInteraction/2323
pathway order: PathwayInteraction/2320
pathway order: PathwayInteraction/2321
pathway component: Interaction2292
pathway component: Interaction2293
pathway component: Interaction2294
pathway component: Interaction2299
pathway component: Interaction2310
pathway component: Interaction2311
pathway component: Interaction2312
pathway component: Reaction179084
pathway component: Interaction2313
pathway component: Interaction2295
pathway component: Interaction2296
pathway component: Interaction2297
pathway component: Interaction2298
pathway component: Interaction2318
pathway component: Interaction2319
pathway component: Reaction115852
pathway component: Interaction2314
pathway component: Interaction2315
pathway component: Interaction2316
pathway component: Interaction2317
pathway component: Interaction2321
pathway component: Interaction2300
pathway component: Interaction2322
pathway component: Interaction2301
pathway component: Interaction2323
pathway component: Interaction2302
pathway component: Interaction2324
pathway component: Interaction2320
pathway component: Interaction2307
pathway component: Interaction2308
pathway component: Interaction2309
pathway component: Reaction179083
pathway component: Interaction2303
pathway component: Reaction179082
pathway component: Interaction2304
pathway component: Interaction2305
pathway component: Interaction2306
pathway component: Reaction115846
xref: Reference/SMPDB SMP0120935
xref: Reference/PathWhiz PW122198
organism: Bos taurus

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

ProteinComplex/11303 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKB1,RELA complex
stoichiometric coefficient: 1.0

Reference/UniProt A6QLK6
type: UnificationXref
id: A6QLK6
db: UniProt

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P04409
organism: Bos taurus

ChemicalStructure/PW C097909
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P32871
type: UnificationXref
id: P32871
db: UniProt

Antigen
type: SmallMoleculeReference

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

T-cell surface glycoprotein CD3 gamma chain
type: Protein
cellular location: Cytoplasm
entity reference: T-cell surface glycoprotein CD3 gamma chain

Interaction2300
type: MolecularInteraction
interaction type: direct_interaction
name: Linker for activation of T-cells family member 1 with Phosphate activates Growth factor receptor-bound protein 2
participant: Linker for activation of T cells
participant: GRB2-related adapter protein

Interaction2301
type: MolecularInteraction
interaction type: direct_interaction
name: Linker for activation of T-cells family member 1 with Phosphate activates Son of sevenless homolog 1
participant: Linker for activation of T cells
participant: Rap guanine nucleotide exchange factor 2

Interaction2302
type: MolecularInteraction
interaction type: direct_interaction
name: Son of sevenless homolog 1 activates RAS guanyl-releasing protein 1
participant: Rap guanine nucleotide exchange factor 2
participant: RAS guanyl-releasing protein 4

Nuclear factor of activated T-cells, cytoplasmic 1
type: ProteinReference
xref: Reference/UniProt P98201
organism: Bos taurus

NF-kappa-B inhibitor zeta
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B inhibitor zeta

Interaction2307
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein phosphatase non-receptor type 7 inhibits Mitogen-activated protein kinase 3 with Phosphate
participant: Receptor-type tyrosine-protein phosphatase F
participant: Mitogen-activated protein kinase 1

Interaction2308
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas activates phosphoinositide (PIK) Complex
participant: phosphoinositide (PIK) Complex
participant: Ras-related protein Rap-1b

Interaction2309
type: MolecularInteraction
interaction type: direct_interaction
name: phosphoinositide (PIK) Complex activates Proto-oncogene vav
participant: phosphoinositide (PIK) Complex
participant: Proto-oncogene vav

phosphoinositide (PIK) Complex
type: Complex
cellular location: Cytoplasm
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
component: Phosphatidylinositol 3-kinase regulatory subunit alpha

Mitogen-activated protein kinase 13
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 13

Interaction2303
type: MolecularInteraction
interaction type: direct_interaction
name: RAS guanyl-releasing protein 1 activates GTPase HRas
participant: Ras-related protein Rap-1b
participant: RAS guanyl-releasing protein 4

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Interaction2304
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase without zinc
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Ras-related protein Rap-1b

Interaction2305
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase without zinc activates Active Dual specificity mitogen-activated protein kinase kinase 1
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2306
type: MolecularInteraction
interaction type: direct_interaction
name: Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate
participant: Mitogen-activated protein kinase 1
participant: Dual specificity mitogen-activated protein kinase kinase 6

Proto-oncogene vav
type: ProteinReference
xref: Reference/UniProt Q08DN7
organism: Bos taurus

Cyclosporin A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Cyclosporin A

Tyrosine-protein kinase Fyn
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase Fyn

Linker for activation of T cells
type: ProteinReference
xref: Reference/UniProt F1MZ60
organism: Bos taurus

Proto-oncogene c-Fos
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene c-Fos

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Reference/UniProt P0CH28
type: UnificationXref
id: P0CH28
db: UniProt

Reference/PubChem-compound 445643
type: UnificationXref
id: 445643
db: PubChem-compound

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inositol 1,4,5-trisphosphate

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: Reference/UniProt A0JNB0
organism: Bos taurus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: Reference/UniProt Q3T0N5
organism: Bos taurus

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/ChemSpider 393220
type: UnificationXref
id: 393220
db: ChemSpider

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Interaction2321
type: MolecularInteraction
interaction type: direct_interaction
name: Calmodulin(123) activates protein phosphatase 3
participant: Calmodulin
participant: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Interaction2322
type: MolecularInteraction
interaction type: direct_interaction
name: Tacrolimus inhibits protein phosphatase 3
participant: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
participant: Tacrolimus

ETS translocation variant 1
type: Protein
cellular location: Cytoplasm
entity reference: ETS translocation variant 1

Interaction2323
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclosporin A inhibits protein phosphatase 3
participant: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
participant: Cyclosporin A

Reference/UniProt Q3T0N5
type: UnificationXref
id: Q3T0N5
db: UniProt

Interaction2324
type: MolecularInteraction
interaction type: direct_interaction
name: protein phosphatase 3 activates Nuclear factor of activated T-cells (Bos taurus) + Phosphate
participant: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
participant: Nuclear factor of activated T-cells (Bos taurus)_Phosphate

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

RAS guanyl-releasing protein 4
type: ProteinReference
xref: Reference/UniProt Q58D14
organism: Bos taurus

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2320
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calmodulin(123)
participant: Calmodulin
participant: Calcium

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt O77627
organism: Bos taurus

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/UniProt F1MZ60
type: UnificationXref
id: F1MZ60
db: UniProt

Reference/PathWhiz PW122198
type: UnificationXref
id: PW122198
db: PathWhiz

NF-kappaB transcription factor p65 subunit
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappaB transcription factor p65 subunit

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/UniProt O77627
type: UnificationXref
id: O77627
db: UniProt

ProteinComplex/12414/Stoichiometry/1.0
type: Stoichiometry
physical entity: T-cell surface glycoprotein CD3
stoichiometric coefficient: 1.0

T-cell surface glycoprotein CD3
type: Complex
cellular location: Cytoplasm
component: T-cell surface glycoprotein CD3 delta chain
component: T-cell surface glycoprotein CD3 epsilon chain
component: T-cell surface glycoprotein CD3 gamma chain
component: CD247 molecule

Reference/UniProt A7YY51
type: UnificationXref
id: A7YY51
db: UniProt

Reference/UniProt G3MXJ1
type: UnificationXref
id: G3MXJ1
db: UniProt

Reference/UniProt Q3T0M4
type: UnificationXref
id: Q3T0M4
db: UniProt

Diacylglycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Diacylglycerol

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt P08487
organism: Bos taurus

Calmodulin
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin

SHC-transforming protein 1
type: Protein
cellular location: Cytoplasm
entity reference: SHC-transforming protein 1

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

CD247 molecule
type: Protein
entity reference: CD247 molecule

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

T-cell surface glycoprotein CD3 epsilon chain
type: Protein
entity reference: T-cell surface glycoprotein CD3 epsilon chain

T-cell surface glycoprotein CD3 delta chain
type: Protein
entity reference: T-cell surface glycoprotein CD3 delta chain

GRB2-related adapter protein
type: Protein
cellular location: Cytoplasm
entity reference: GRB2-related adapter protein

BoundComplex/429 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells (Bos taurus)_Phosphate
stoichiometric coefficient: 1.0

Ras-related protein Rap-1b
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related protein Rap-1b

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

T-cell surface glycoprotein CD3 gamma chain
type: Protein
entity reference: T-cell surface glycoprotein CD3 gamma chain

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt Q3SZA7
type: UnificationXref
id: Q3SZA7
db: UniProt

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt A5D7N0
organism: Bos taurus

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Tacrolimus
type: SmallMoleculeReference
xref: Reference/CAS 104987-11-3
xref: Reference/KEGG Compound C01375
xref: Reference/PubChem-compound 445643
xref: Reference/ChEBI CHEBI 61049
xref: Reference/HMDB HMDB0015002
xref: Reference/ChemSpider 393220
chemical formula: C44H69NO12
molecular weight: 803.482
structure: ChemicalStructure/PW C009318

Uncharacterized protein
type: Protein
entity reference: Uncharacterized protein

Reference/ChEBI CHEBI 61049
type: UnificationXref
id: CHEBI:61049
db: ChEBI

CD247 molecule
type: Protein
cellular location: Cytoplasm
entity reference: CD247 molecule

Uncharacterized protein
type: Protein
entity reference: Uncharacterized protein

ProteinComplex/11301 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase C complex
stoichiometric coefficient: 1.0

Reference/UniProt F1MC47
type: UnificationXref
id: F1MC47
db: UniProt

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Reference/UniProt A5D7N0
type: UnificationXref
id: A5D7N0
db: UniProt

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Reference/UniProt Q45KX9
type: UnificationXref
id: Q45KX9
db: UniProt

Nuclear factor of activated T-cells, cytoplasmic 1
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor of activated T-cells, cytoplasmic 1

Reference/CAS 104987-11-3
type: UnificationXref
id: 104987-11-3
db: CAS

Reference/UniProt A2VE60
type: UnificationXref
id: A2VE60
db: UniProt

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt A2VE60
organism: Bos taurus

Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q3SZH3
type: UnificationXref
id: Q3SZH3
db: UniProt

Proto-oncogene c-Fos
type: ProteinReference
xref: Reference/UniProt Q7YRP7
organism: Bos taurus

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

Reference/UniProt P08487
type: UnificationXref
id: P08487
db: UniProt

ProteinComplex/12413/Stoichiometry/1.0
type: Stoichiometry
physical entity: T cell receptor
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Protein/21129 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells, cytoplasmic 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01375
type: UnificationXref
id: C01375
db: KEGG Compound

RAS guanyl-releasing protein 4
type: Protein
cellular location: Cytoplasm
entity reference: RAS guanyl-releasing protein 4

Reference/SMPDB SMP0120935
type: UnificationXref
id: SMP0120935
db: SMPDB

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

ProteinComplex/12326 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKB1,NFKBIA,RELA,Ub Complex with Phosphate
stoichiometric coefficient: 1.0

Reference/UniProt A0JNB0
type: UnificationXref
id: A0JNB0
db: UniProt

ChemicalStructure/PW C009318
type: ChemicalStructure
structure format: SMILES

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

ETS translocation variant 1
type: ProteinReference
xref: Reference/UniProt Q2KIC2
organism: Bos taurus

SHC-transforming protein 1
type: ProteinReference
xref: Reference/UniProt Q45KX9
organism: Bos taurus

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Cyclosporin A
type: SmallMoleculeReference
chemical formula: C62H111N11O12
molecular weight: 1201.8413
structure: ChemicalStructure/PW C097909

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cytoplasm
entity reference: Rap guanine nucleotide exchange factor 2

T cell receptor
type: Complex
component: Uncharacterized protein

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C alpha type
component: Protein kinase C beta type

T-cell surface glycoprotein CD3
type: Complex
component: T-cell surface glycoprotein CD3 gamma chain
component: CD247 molecule
component: T-cell surface glycoprotein CD3 epsilon chain
component: T-cell surface glycoprotein CD3 delta chain

Reference/UniProt Q08DN7
type: UnificationXref
id: Q08DN7
db: UniProt

Polyubiquitin-C
type: Protein
cellular location: Cytoplasm
entity reference: Polyubiquitin-C

Reaction179084
type: BiochemicalReaction
participant stoichiometry: BoundComplex/429 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/21129 Cytoplasm/Stoichiometry/1.0
right: Nuclear factor of activated T-cells, cytoplasmic 1
right: Phosphate
spontaneous: false
left: Nuclear factor of activated T-cells (Bos taurus)_Phosphate
name: Nuclear factor of activated T-cells (Bos taurus) + Phosphate → Nuclear factor of activated T-cells + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Reaction115852
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: Reference/UniProt P23727
organism: Bos taurus

Protein/19514 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor zeta
stoichiometric coefficient: 1.0

Ras-related protein Rap-1b
type: ProteinReference
xref: Reference/UniProt Q3T0M4
organism: Bos taurus

Reference/UniProt A1XG22
type: UnificationXref
id: A1XG22
db: UniProt

NFKB1,NFKBIA,RELA,Ub Complex with Phosphate
type: Complex
cellular location: Cytoplasm
component: NF-kappa-B inhibitor zeta
component: NF-kappaB transcription factor p65 subunit
component: Polyubiquitin-C

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Reaction179083
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/12326 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/19514 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11303 Cytoplasm/Stoichiometry/1.0
right: NF-kappa-B inhibitor zeta
right: NFKB1,RELA complex
spontaneous: false
left: NFKB1,NFKBIA,RELA,Ub Complex with Phosphate
name: NFKB1,NFKBIA,RELA,Ub Complex with Phosphate → NFKB1,RELA complex + NFKBIA with phosphate
conversion direction: LEFT_TO_RIGHT

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Reaction179082
type: BiochemicalReaction
participant stoichiometry: Protein/19592 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
right: Phosphatidylinositol 4,5-bisphosphate
spontaneous: false
left: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
left: Water
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 without zinc + Water → Phosphatidylinositol 4,5-bisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q0VCU4
type: UnificationXref
id: Q0VCU4
db: UniProt

Reference/UniProt F1MSG6
type: UnificationXref
id: F1MSG6
db: UniProt

Aurora kinase A
type: ProteinReference
xref: Reference/UniProt Q2TA06
organism: Bos taurus

Reference/UniProt A7Z059
type: UnificationXref
id: A7Z059
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Interaction2292
type: MolecularInteraction
interaction type: direct_interaction
name: T cell receptor (Bos taurus) + T-cell surface glycoprotein CD3 (Bos taurus) activates Tyrosine-protein kinase Lck
participant: T cell receptor (Bos taurus)_T-cell surface glycoprotein CD3 (Bos taurus)
participant: Tyrosine-protein kinase Fyn

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt Q3ZBW9
organism: Bos taurus

Interaction2293
type: MolecularInteraction
interaction type: direct_interaction
name: Antigen activates T cell receptor (Bos taurus) + T-cell surface glycoprotein CD3 (Bos taurus)
participant: T cell receptor (Bos taurus)_T-cell surface glycoprotein CD3 (Bos taurus)
participant: Antigen

Interaction2294
type: MolecularInteraction
interaction type: direct_interaction
name: T cell receptor (Bos taurus) + T-cell surface glycoprotein CD3 (Bos taurus) activates Tyrosine-protein kinase ZAP-70
participant: T cell receptor (Bos taurus)_T-cell surface glycoprotein CD3 (Bos taurus)
participant: Tyrosine-protein kinase

Interaction2299
type: MolecularInteraction
interaction type: direct_interaction
name: Linker for activation of T-cells family member 1 with Phosphate activates SHC-transforming protein 1
participant: Linker for activation of T cells
participant: SHC-transforming protein 1

NFKB1,RELA complex
type: Complex
cellular location: Cytoplasm
component: NF-kappa-B inhibitor zeta
component: NF-kappaB transcription factor p65 subunit

Reference/UniProt Q58D14
type: UnificationXref
id: Q58D14
db: UniProt

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Interaction2295
type: MolecularInteraction
interaction type: direct_interaction
name: T cell receptor (Bos taurus) + T-cell surface glycoprotein CD3 (Bos taurus) activates Tyrosine-protein kinase Fyn without Mg
participant: T cell receptor (Bos taurus)_T-cell surface glycoprotein CD3 (Bos taurus)
participant: Tyrosine-protein kinase Fyn

Interaction2296
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase ZAP-70 activates Proto-oncogene vav
participant: Tyrosine-protein kinase
participant: Proto-oncogene vav

Interaction2297
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase Fyn without Mg activates Proto-oncogene vav
participant: Tyrosine-protein kinase Fyn
participant: Proto-oncogene vav

Proto-oncogene vav
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene vav

Interaction2298
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase ZAP-70 activates Linker for activation of T-cells family member 1 with Phosphate
participant: Linker for activation of T cells
participant: Tyrosine-protein kinase

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Reference/UniProt Q32PK0
type: UnificationXref
id: Q32PK0
db: UniProt

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Protein
cellular location: Cytoplasm
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Polyubiquitin-C
type: ProteinReference
xref: Reference/UniProt P0CH28
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha

Receptor-type tyrosine-protein phosphatase F
type: ProteinReference
xref: Reference/UniProt A7MBJ4
organism: Bos taurus

T-cell surface glycoprotein CD3 epsilon chain
type: Protein
cellular location: Cytoplasm
entity reference: T-cell surface glycoprotein CD3 epsilon chain

Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P98201
type: UnificationXref
id: P98201
db: UniProt

Calmodulin
type: ProteinReference
xref: Reference/UniProt Q2KJE6
organism: Bos taurus

Tacrolimus
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tacrolimus

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt Q309F2
organism: Bos taurus

Reference/UniProt P04409
type: UnificationXref
id: P04409
db: UniProt

GRB2-related adapter protein
type: ProteinReference
xref: Reference/UniProt A6QLK6
organism: Bos taurus

Reference/UniProt Q3ZBW9
type: UnificationXref
id: Q3ZBW9
db: UniProt

ProteinComplex/12413 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: T cell receptor
stoichiometric coefficient: 1.0

Reference/UniProt Q5E9X2
type: UnificationXref
id: Q5E9X2
db: UniProt

T-cell surface glycoprotein CD3 gamma chain
type: ProteinReference
xref: Reference/UniProt Q3SZA7
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt F1MC47
organism: Bos taurus

T-cell surface glycoprotein CD3 delta chain
type: Protein
cellular location: Cytoplasm
entity reference: T-cell surface glycoprotein CD3 delta chain

Protein kinase C complex (Bos taurus)_Calcium
type: Complex
component stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/11301 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Protein kinase C complex
component: Calcium

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt G3MXJ1
organism: Bos taurus

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt Q3ZCH2
type: UnificationXref
id: Q3ZCH2
db: UniProt

NF-kappa-B inhibitor zeta
type: ProteinReference
xref: Reference/UniProt A7Z059
organism: Bos taurus

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt P32871
organism: Bos taurus

Receptor-type tyrosine-protein phosphatase F
type: Protein
cellular location: Cytoplasm
entity reference: Receptor-type tyrosine-protein phosphatase F

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt A7YY51
organism: Bos taurus

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related C3 botulinum toxin substrate 1

Linker for activation of T cells
type: Protein
cellular location: Cytoplasm
entity reference: Linker for activation of T cells

Nuclear factor of activated T-cells (Bos taurus)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21129 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Nuclear factor of activated T-cells, cytoplasmic 1
component: Phosphate

Reference/UniProt Q2TA06
type: UnificationXref
id: Q2TA06
db: UniProt

CD247 molecule
type: ProteinReference
xref: Reference/UniProt Q0VCU4
organism: Bos taurus

NF-kappaB transcription factor p65 subunit
type: ProteinReference
xref: Reference/UniProt A1XG22
organism: Bos taurus

T-cell surface glycoprotein CD3 delta chain
type: ProteinReference
xref: Reference/UniProt Q3SZH3
organism: Bos taurus

ProteinComplex/12414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: T-cell surface glycoprotein CD3
stoichiometric coefficient: 1.0

T-cell surface glycoprotein CD3 epsilon chain
type: ProteinReference
xref: Reference/UniProt Q3ZCH2
organism: Bos taurus

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt Q5E9X2
organism: Bos taurus

Reference/UniProt P23727
type: UnificationXref
id: P23727
db: UniProt