direct_interaction
type: InteractionVocabulary

Reference/UniProt Q95KV0
type: UnificationXref
id: Q95KV0
db: UniProt

Protein/21289 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Reference/UniProt Q5EA16
type: UnificationXref
id: Q5EA16
db: UniProt

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Reference/UniProt Q9TVA7
type: UnificationXref
id: Q9TVA7
db: UniProt

Mitogen-activated protein kinase 13
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 13

Protein/22182 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte antigen 96
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 59309
type: UnificationXref
id: CHEBI:59309
db: ChEBI

TNF receptor-associated factor 6
type: ProteinReference
xref: Reference/UniProt Q3ZCC3
organism: Bos taurus

Aurora kinase A
type: Protein
cellular location: Cytoplasm
entity reference: Aurora kinase A

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Lymphocyte antigen 96
type: Protein
cellular location: Cytoplasm
entity reference: Lymphocyte antigen 96

NF-kappa-B essential modulator
type: ProteinReference
xref: Reference/UniProt Q5EA16
organism: Bos taurus

Toll-Like Receptor Pathway 2
type: Pathway
pathway order: PathwayInteraction/2339
pathway order: PathwayInteraction/2337
pathway order: PathwayInteraction/2359
pathway order: PathwayInteraction/2338
pathway order: PathwayInteraction/2335
pathway order: PathwayInteraction/2357
pathway order: PathwayInteraction/2336
pathway order: PathwayInteraction/2358
pathway order: PathwayInteraction/2333
pathway order: PathwayInteraction/2355
pathway order: PathwayInteraction/2334
pathway order: PathwayInteraction/2356
pathway order: PathwayInteraction/2331
pathway order: PathwayInteraction/2353
pathway order: PathwayInteraction/2332
pathway order: PathwayInteraction/2354
pathway order: PathwayInteraction/2351
pathway order: PathwayInteraction/2330
pathway order: PathwayInteraction/2352
pathway order: PathwayInteraction/2350
pathway order: PathwayEnzymeReaction/2120457
pathway order: PathwayInteraction/2329
pathway order: PathwayInteraction/2348
pathway order: PathwayInteraction/2349
pathway order: PathwayInteraction/2346
pathway order: PathwayInteraction/2347
pathway order: PathwayInteraction/2344
pathway order: PathwayInteraction/2345
pathway order: PathwayInteraction/2342
pathway order: PathwayInteraction/2343
pathway order: PathwayInteraction/2340
pathway order: PathwayInteraction/2341
pathway order: PathwayInteraction/2360
pathway component: Interaction2332
pathway component: Interaction2354
pathway component: Interaction2333
pathway component: Interaction2355
pathway component: Reaction179085
pathway component: Interaction2334
pathway component: Interaction2356
pathway component: Interaction2335
pathway component: Interaction2357
pathway component: Interaction2350
pathway component: Interaction2351
pathway component: Interaction2330
pathway component: Interaction2352
pathway component: Interaction2331
pathway component: Interaction2353
pathway component: Interaction2336
pathway component: Interaction2358
pathway component: Interaction2337
pathway component: Interaction2359
pathway component: Interaction2338
pathway component: Interaction2339
pathway component: Interaction2360
pathway component: Interaction2343
pathway component: Interaction2344
pathway component: Interaction2345
pathway component: Interaction2346
pathway component: Interaction2340
pathway component: Interaction2341
pathway component: Interaction2342
pathway component: Interaction2329
pathway component: Interaction2347
pathway component: Interaction2348
pathway component: Interaction2349
xref: Reference/PathWhiz PW122200
xref: Reference/SMPDB SMP0120937
organism: Bos taurus

ProteinComplex/11303 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKB1,RELA complex
stoichiometric coefficient: 1.0

Monocyte differentiation antigen CD14
type: Protein
entity reference: Monocyte differentiation antigen CD14

Interleukin-1 receptor-associated kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Interleukin-1 receptor-associated kinase 1

CpG-DNA
type: DnaReference
organism: Bos taurus

Double-Stranded RNA
type: DnaReference
organism: Bos taurus

Reference/UniProt Q706D2
type: UnificationXref
id: Q706D2
db: UniProt

MAP3K7IP1 protein
type: Protein
cellular location: Cytoplasm
entity reference: MAP3K7IP1 protein

Liproproteins
type: ProteinReference
organism: Bos taurus

NF-kappa-B inhibitor zeta
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B inhibitor zeta

LPS core
type: SmallMolecule
cellular location: Cell Membrane
entity reference: LPS core

Reference/UniProt Q58D12
type: UnificationXref
id: Q58D12
db: UniProt

Imiquimod
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014862
xref: Reference/ChEBI CHEBI 36704
xref: Reference/ChemSpider 51809
xref: Reference/PubChem-compound 57469
xref: Reference/CAS 99011-02-6
chemical formula: C14H16N4
molecular weight: 240.1375
structure: ChemicalStructure/PW C009198

NF-kappa-B essential modulator
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B essential modulator

Imiquimod
type: SmallMolecule
entity reference: Imiquimod

Mitogen-activated protein kinase kinase kinase 7
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 7

Reference/UniProt Q3SX05
type: UnificationXref
id: Q3SX05
db: UniProt

Interaction2332
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR1,2
participant: Liproproteins
participant: TLR1,2

Interaction2333
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR1,2
participant: Monocyte differentiation antigen CD14
participant: TLR1,2

Reference/UniProt A7YWD1
type: UnificationXref
id: A7YWD1
db: UniProt

Interaction2334
type: MolecularInteraction
interaction type: direct_interaction
name: TLR1,2 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: TLR1,2

Interaction2335
type: MolecularInteraction
interaction type: direct_interaction
name: TLR2,6 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: TLR2,6

Interaction2330
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR2,6
participant: Liproproteins
participant: TLR2,6

Reference/BioCyc CPD0-2271
type: UnificationXref
id: CPD0-2271
db: BioCyc

Interaction2331
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR2,6
participant: Monocyte differentiation antigen CD14
participant: TLR2,6

TGF-beta activated kinase 1 and MAP3K7 binding protein 3
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta activated kinase 1 and MAP3K7 binding protein 3

Interaction2336
type: MolecularInteraction
interaction type: direct_interaction
name: MYD88,IRAK (myddosome) activates TNF receptor-associated factor 6
participant: MYD88,IRAK (myddosome)
participant: TNF receptor-associated factor 6

Interaction2337
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Toll-like receptor 4 (Bos taurus) + Lymphocyte antigen 96 (Bos taurus)
participant: Toll-like receptor 4 (Bos taurus)_Lymphocyte antigen 96 (Bos taurus)
participant: LPS core

Interaction2338
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Monocyte differentiation antigen CD14
participant: LPS core
participant: Monocyte differentiation antigen CD14

Reference/KEGG Compound c0338
type: UnificationXref
id: c0338
db: KEGG Compound

Interaction2339
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates Toll-like receptor 4 (Bos taurus) + Lymphocyte antigen 96 (Bos taurus)
participant: Toll-like receptor 4 (Bos taurus)_Lymphocyte antigen 96 (Bos taurus)
participant: Monocyte differentiation antigen CD14

Toll-interacting protein
type: ProteinReference
xref: Reference/UniProt Q58D12
organism: Bos taurus

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Lymphocyte antigen 96
type: ProteinReference
xref: Reference/UniProt P58754
organism: Bos taurus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: Reference/UniProt Q3T0N5
organism: Bos taurus

Reference/UniProt A6QQK2
type: UnificationXref
id: A6QQK2
db: UniProt

Reference/HMDB HMDB0014862
type: UnificationXref
id: HMDB0014862
db: HMDB

Reference/UniProt Q3T0N5
type: UnificationXref
id: Q3T0N5
db: UniProt

ProteinComplex/11302 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKBIA, NFKB1, RELA complex
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2329
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates Monocyte differentiation antigen CD14
participant: Monocyte differentiation antigen CD14
participant: Liproproteins

Reference/ChemSpider 51809
type: UnificationXref
id: 51809
db: ChemSpider

NF-kappaB transcription factor p65 subunit
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappaB transcription factor p65 subunit

Reference/PubChem-compound 53481794
type: UnificationXref
id: 53481794
db: PubChem-compound

Reference/UniProt E1B7Z0
type: UnificationXref
id: E1B7Z0
db: UniProt

ChemicalStructure/PW C009198
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)CN1C=NC2=C1C1=CC=CC=C1N=C2N

Reference/UniProt P58754
type: UnificationXref
id: P58754
db: UniProt

Liproproteins
type: Protein
cellular location: Cytoplasm
entity reference: Liproproteins

Interaction2354
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Inhibitor of nuclear factor kappa-B kinase
participant: Aurora kinase A
participant: Inhibitor of nuclear factor kappa-B kinase

Interaction2355
type: MolecularInteraction
interaction type: direct_interaction
name: Inhibitor of nuclear factor kappa-B kinase activates NFKBIA, NFKB1, RELA complex
participant: NFKBIA, NFKB1, RELA complex
participant: Inhibitor of nuclear factor kappa-B kinase

Interaction2356
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Mitogen-activated protein kinase kinase kinase 7 (Bos taurus) + TAB Complex (Bos taurus)
participant: Mitogen-activated protein kinase kinase kinase 7 (Bos taurus)_TAB Complex (Bos taurus)
participant: TNF receptor-associated factor 6

Interaction2357
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Bos taurus) + TAB Complex (Bos taurus) activates Mitogen-activated protein kinase kinase kinase 14
participant: Mitogen-activated protein kinase kinase kinase 7 (Bos taurus)_TAB Complex (Bos taurus)
participant: Mitogen-activated protein kinase 13

Interaction2350
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 7 activates MYD88,IRAK (myddosome)
participant: Toll-like receptor 9
participant: MYD88,IRAK (myddosome)

Toll-like receptor 4 (Bos taurus)_Lymphocyte antigen 96 (Bos taurus)
type: Complex
component stoichiometry: Protein/22182 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21289 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-like receptor 4
component: Lymphocyte antigen 96

Interaction2351
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 5 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 3

Interaction2352
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: TNF receptor-associated factor 6

Interaction2353
type: MolecularInteraction
interaction type: direct_interaction
name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: Aurora kinase A

Interaction2358
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 14 activates Inhibitor of nuclear factor kappa-B kinase
participant: Mitogen-activated protein kinase 13
participant: Inhibitor of nuclear factor kappa-B kinase

Toll-like receptor 9
type: ProteinReference
xref: Reference/UniProt Q5I2M5
organism: Bos taurus

Interaction2359
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Bos taurus) + TAB Complex (Bos taurus) activates Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate
participant: Mitogen-activated protein kinase kinase kinase 7 (Bos taurus)_TAB Complex (Bos taurus)
participant: Dual specificity mitogen-activated protein kinase kinase 6

Protein/22098 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TIR domain containing adaptor protein
stoichiometric coefficient: 1.0

Interaction2343
type: MolecularInteraction
interaction type: direct_interaction
name: Imiquimod activates Toll-like receptor 7
participant: Imiquimod
participant: Toll-like receptor 9

Interaction2344
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 3
participant: Double-Stranded RNA
participant: Toll-like receptor 3

Interaction2345
type: MolecularInteraction
interaction type: direct_interaction
name: Flagellin activates Toll-like receptor 5
participant: Toll-like receptor 3
participant: Unknown

Interaction2346
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 8
participant: Double-Stranded RNA
participant: Toll-like receptor 9

Interaction2340
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 4 (Bos taurus) + Lymphocyte antigen 96 (Bos taurus) activates Toll/interleukin-1 receptor domain-containing adapter protein (Bos taurus) + Toll-interacting protein (Bos taurus)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Bos taurus)_Toll-interacting protein (Bos taurus)
participant: Toll-like receptor 4 (Bos taurus)_Lymphocyte antigen 96 (Bos taurus)

Interaction2341
type: MolecularInteraction
interaction type: direct_interaction
name: Toll/interleukin-1 receptor domain-containing adapter protein (Bos taurus) + Toll-interacting protein (Bos taurus) activates MYD88,IRAK (myddosome)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Bos taurus)_Toll-interacting protein (Bos taurus)
participant: MYD88,IRAK (myddosome)

Interaction2342
type: MolecularInteraction
interaction type: direct_interaction
name: CpG-DNA activates Toll-like receptor 9
participant: CpG-DNA
participant: Toll-like receptor 9

Interaction2347
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 9 activates MYD88,IRAK (myddosome)
participant: Toll-like receptor 9
participant: MYD88,IRAK (myddosome)

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Interaction2348
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 3 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 3

TIR domain containing adaptor protein
type: ProteinReference
xref: Reference/UniProt Q2LGB6
organism: Bos taurus

Interaction2349
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 8 activates MYD88,IRAK (myddosome)
participant: Toll-like receptor 9
participant: MYD88,IRAK (myddosome)

Reference/UniProt Q5TJ59
type: UnificationXref
id: Q5TJ59
db: UniProt

Toll-like receptor 6
type: ProteinReference
xref: Reference/UniProt Q706D2
organism: Bos taurus

Toll-like receptor 2
type: ProteinReference
xref: Reference/UniProt Q9GL66
organism: Bos taurus

ProteinComplex/12445 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TAB Complex
stoichiometric coefficient: 1.0

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Mitogen-activated protein kinase kinase kinase 7 (Bos taurus)_TAB Complex (Bos taurus)
type: Complex
component stoichiometry: ProteinComplex/12445 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21068 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase kinase kinase 7
component: TAB Complex

MAP3K7IP1 protein
type: ProteinReference
xref: Reference/UniProt A6QQK2
organism: Bos taurus

Lymphocyte antigen 96
type: Protein
cellular location: Cell Membrane
entity reference: Lymphocyte antigen 96

Reference/UniProt A2VDU3
type: UnificationXref
id: A2VDU3
db: UniProt

Toll-like receptor 3
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 3

Toll-like receptor 2
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 2

Interaction2360
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate activates Mitogen-activated protein kinase 8 without Magnesium
participant: Mitogen-activated protein kinase 13
participant: Dual specificity mitogen-activated protein kinase kinase 6

TGF-beta activated kinase 1/MAP3K7 binding protein 2
type: ProteinReference
xref: Reference/UniProt E1B7Z0
organism: Bos taurus

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

TGF-beta activated kinase 1 and MAP3K7 binding protein 3
type: ProteinReference
xref: Reference/UniProt G3N227
organism: Bos taurus

Toll-like receptor 3
type: Protein
entity reference: Toll-like receptor 3

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cytoplasm
entity reference: Monocyte differentiation antigen CD14

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: Reference/UniProt A2VDU3
organism: Bos taurus

Reference/UniProt Q6GV19
type: UnificationXref
id: Q6GV19
db: UniProt

Double-Stranded RNA
type: Dna
entity reference: Double-Stranded RNA

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

CpG-DNA
type: Dna
entity reference: CpG-DNA

Reference/SMPDB SMP0120937
type: UnificationXref
id: SMP0120937
db: SMPDB

MYD88,IRAK (myddosome)
type: Complex
cellular location: Cytoplasm
component: Interleukin-1 receptor-associated kinase 1
component: Myeloid differentiation primary response protein MyD88

Reaction179085
type: BiochemicalReaction
participant stoichiometry: Protein/19514 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11303 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11302 Cytoplasm/Stoichiometry/1.0
right: NF-kappa-B inhibitor zeta
right: NFKB1,RELA complex
spontaneous: false
left: NFKBIA, NFKB1, RELA complex
name: NFKBIA, NFKB1, RELA complex → NFKB1,RELA complex + NFKBIA with phosphate
conversion direction: LEFT_TO_RIGHT

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Protein/19514 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor zeta
stoichiometric coefficient: 1.0

Protein/21289 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Unknown
type: Protein
entity reference: Unknown

Reference/UniProt Q2LGB6
type: UnificationXref
id: Q2LGB6
db: UniProt

Reference/CAS 99011-02-6
type: UnificationXref
id: 99011-02-6
db: CAS

Reference/UniProt A1XG22
type: UnificationXref
id: A1XG22
db: UniProt

Reference/UniProt Q2LGB3
type: UnificationXref
id: Q2LGB3
db: UniProt

Reference/UniProt Q6GV22
type: UnificationXref
id: Q6GV22
db: UniProt

Toll-like receptor 4 (Bos taurus)_Lymphocyte antigen 96 (Bos taurus)
type: Complex
component stoichiometry: Protein/21289 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/22182 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Lymphocyte antigen 96
component: Toll-like receptor 4

Toll/interleukin-1 receptor domain-containing adapter protein (Bos taurus)_Toll-interacting protein (Bos taurus)
type: Complex
component stoichiometry: Protein/22187 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22098 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-interacting protein
component: TIR domain containing adaptor protein

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q3SX05
organism: Bos taurus

Reference/PubChem-compound 57469
type: UnificationXref
id: 57469
db: PubChem-compound

Reference/HMDB HMDB0013471
type: UnificationXref
id: HMDB0013471
db: HMDB

Monocyte differentiation antigen CD14
type: ProteinReference
xref: Reference/UniProt Q9TVA7
organism: Bos taurus

Reference/UniProt Q3ZCC3
type: UnificationXref
id: Q3ZCC3
db: UniProt

Double-Stranded RNA
type: Dna
cellular location: Cytoplasm
entity reference: Double-Stranded RNA

LPS core
type: SmallMolecule
entity reference: LPS core

Aurora kinase A
type: ProteinReference
xref: Reference/UniProt Q2TA06
organism: Bos taurus

Reference/UniProt A7Z059
type: UnificationXref
id: A7Z059
db: UniProt

Toll-interacting protein
type: Protein
cellular location: Cytoplasm
entity reference: Toll-interacting protein

LPS core
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 59309
xref: Reference/KEGG Compound c0338
xref: Reference/PubChem-compound 53481794
xref: Reference/HMDB HMDB0013471
xref: Reference/BioCyc CPD0-2271
chemical formula: C175H317N5O101P6
molecular weight: 4290.8247
structure: ChemicalStructure/PW C008388

Protein/22182 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte antigen 96
stoichiometric coefficient: 1.0

TNF receptor-associated factor 6
type: Protein
cellular location: Cytoplasm
entity reference: TNF receptor-associated factor 6

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cell Membrane
entity reference: Monocyte differentiation antigen CD14

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4

NFKB1,RELA complex
type: Complex
cellular location: Cytoplasm
component: NF-kappa-B inhibitor zeta
component: NF-kappaB transcription factor p65 subunit

Toll-like receptor 3
type: ProteinReference
xref: Reference/UniProt Q5TJ59
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase
type: Complex
cellular location: Cytoplasm
component: Inhibitor of nuclear factor kappa-B kinase subunit beta
component: Inhibitor of nuclear factor kappa-B kinase subunit alpha
component: NF-kappa-B essential modulator

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt Q6GV22
organism: Bos taurus

Interleukin-1 receptor-associated kinase 1
type: ProteinReference
xref: Reference/UniProt Q2LGB3
organism: Bos taurus

TLR1,2
type: Complex
cellular location: Cytoplasm
component: Toll-like receptor 2
component: Toll-like receptor 6

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt Q95KV0
organism: Bos taurus

NFKBIA, NFKB1, RELA complex
type: Complex
cellular location: Cytoplasm
component: NF-kappa-B inhibitor zeta
component: NF-kappaB transcription factor p65 subunit

Reference/UniProt Q5I2M5
type: UnificationXref
id: Q5I2M5
db: UniProt

TGF-beta activated kinase 1/MAP3K7 binding protein 2
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta activated kinase 1/MAP3K7 binding protein 2

TLR2,6
type: Complex
cellular location: Cytoplasm
component: Toll-like receptor 2
component: Toll-like receptor 6

ChemicalStructure/PW C008388
type: ChemicalStructure
structure format: SMILES

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: Reference/UniProt A7YWD1
organism: Bos taurus

TIR domain containing adaptor protein
type: Protein
cellular location: Cytoplasm
entity reference: TIR domain containing adaptor protein

Reference/UniProt Q5E9X2
type: UnificationXref
id: Q5E9X2
db: UniProt

Reference/PathWhiz PW122200
type: UnificationXref
id: PW122200
db: PathWhiz

Protein/21068 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase kinase kinase 7
stoichiometric coefficient: 1.0

NF-kappa-B inhibitor zeta
type: ProteinReference
xref: Reference/UniProt A7Z059
organism: Bos taurus

TAB Complex
type: Complex
cellular location: Cytoplasm
component: TGF-beta activated kinase 1/MAP3K7 binding protein 2
component: MAP3K7IP1 protein
component: TGF-beta activated kinase 1 and MAP3K7 binding protein 3

Protein/22187 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-interacting protein
stoichiometric coefficient: 1.0

Toll-like receptor 9
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 9

Reference/UniProt G3N227
type: UnificationXref
id: G3N227
db: UniProt

Reference/UniProt Q2TA06
type: UnificationXref
id: Q2TA06
db: UniProt

Unknown
type: ProteinReference
organism: Bos taurus

Toll-like receptor 6
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 6

NF-kappaB transcription factor p65 subunit
type: ProteinReference
xref: Reference/UniProt A1XG22
organism: Bos taurus

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt Q6GV19
organism: Bos taurus

Reference/ChEBI CHEBI 36704
type: UnificationXref
id: CHEBI:36704
db: ChEBI

Reference/UniProt Q9GL66
type: UnificationXref
id: Q9GL66
db: UniProt

Toll-like receptor 9
type: Protein
entity reference: Toll-like receptor 9

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt Q5E9X2
organism: Bos taurus