937
ChemSpider
Interaction2410
Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
Interaction2411
Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 8 without Magnesium
F1MMQ7
UniProt
B-cell receptor
Interaction2412
Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 14 with Magnesium
TransportCatalysis1449
ACTIVATION
direct_interaction
Interaction2413
Mitogen-activated protein kinase 14 with Magnesium activates FOS,JUN Complex
SMILES
O
Q2KJE6
UniProt
Q2KIC2
UniProt
1.0
9913
TAXONOMY
1.0
Q7YRP7
UniProt
Mitogen-activated protein kinase 13
Interaction2400
GRB2/SOS complex activates GTPase HRas with GTP
Interaction2401
Tyrosine-protein kinase SYK with Phosphate activates Tyrosine-protein kinase BTK with Phosphate
Q309F2
UniProt
CD79b molecule
SMILES
CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
Interaction2406
GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase with Phosphate
B-cell antigen receptor complex-associated protein alpha chain
Interaction2407
RAF proto-oncogene serine/threonine-protein kinase with Phosphate activates Active Dual specificity mitogen-activated protein kinase kinase 1
Interaction2408
Mitogen-activated protein kinase 3 with Phosphate activates FOS,JUN Complex
Interaction2409
Proto-oncogene vav with Phosphate activates Ras-related C3 botulinum toxin substrate 1
Interaction2402
Tyrosine-protein kinase SYK with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate
Water
Interaction2403
Diacylglycerol activates Protein kinase C complex
Mitogen-activated protein kinase 1
Interaction2404
Calcium activates Protein kinase C complex
Interaction2405
Protein kinase C complex activates ETS domain-containing protein Elk-1
Aurora kinase A
GRB2/SOS complex
BCR Signaling Pathway
1.0
B-cell antigen receptor complex-associated protein
CHEBI:16595
ChEBI
Rap guanine nucleotide exchange factor 2
B-cell receptor
85166-31-0
CAS
A6QLK6
UniProt
B-cell antigen receptor complex-associated protein alpha chain
Protein kinase C alpha type
SMILES
CCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC\C=C\CCCCCCCC
O4P
Phosphate
94.95342
Transport10257
false
Calcium (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytoplasm
LEFT_TO_RIGHT
Nuclear factor of activated T-cells, cytoplasmic 1
266
ChemSpider
Interaction2306
Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate
Proto-oncogene vav
Tyrosine-protein kinase Fyn
ORAI calcium release-activated calcium modulator 1
Proto-oncogene c-Fos
B-cell antigen receptor complex-associated protein (Bos taurus)_B-cell receptor_Phosphate
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
6026790
PubChem-compound
SMILES
[O-]P([O-])([O-])=O
Inositol 1,4,5-trisphosphate
Tyrosine-protein kinase Fyn
Mitogen-activated protein kinase 13
inositol_1,4,5-trisphosphate
BioCyc
C00009
KEGG Compound
C00001
KEGG Compound
HMDB0001429
HMDB
Interaction2321
Calmodulin(123) activates protein phosphatase 3
ETS translocation variant 1
Interaction2324
protein phosphatase 3 activates Nuclear factor of activated T-cells (Bos taurus) + Phosphate
Q3T0N5
UniProt
CHEBI:18367
ChEBI
1032
ChemSpider
388562
ChemSpider
Interaction2320
Calcium activates Calmodulin(123)
Dual specificity mitogen-activated protein kinase kinase 6
HMDB0000464
HMDB
Transcription factor AP-1
ORAI calcium release-activated calcium modulator 1
Activated CDC42 kinase 1
24742074
PubChem-compound
Phosphatidylinositol 4,5-bisphosphate
O77627
UniProt
1.0
A7YY51
UniProt
Interaction2113
Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex
Q3T0M4
UniProt
Diacylglycerol
Extracellular Space
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Calmodulin
SHC-transforming protein 1
1.0
14127-61-8
CAS
SMILES
[Ca++]
GRB2-related adapter protein
1.0
Calcium
Ras-related protein Rap-1b
C47H80O19P3
Phosphatidylinositol 4,5-bisphosphate
1041.4507
Protein kinase C alpha type
C6H15O15P3
Inositol 1,4,5-trisphosphate
419.96237
GO:0005615
GENE ONTOLOGY
Interaction2105
GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate
GO:0005737
GENE ONTOLOGY
CHEBI:29108
ChEBI
Protein kinase C beta type
Activated CDC42 kinase 1
A5D7N0
UniProt
CPD-8587
BioCyc
C01245
KEGG Compound
Q45KX9
UniProt
Nuclear factor of activated T-cells, cytoplasmic 1
B cell linker
A2VE60
UniProt
SMP0120940
SMPDB
1.0
Calcium
Mitogen-activated protein kinase 1
1.0
Proto-oncogene c-Fos
P08487
UniProt
C37H70O5
Diacylglycerol
594.52234
1.0
SMILES
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
A0JNB0
UniProt
Bos taurus
Q28134
UniProt
ETS translocation variant 1
SHC-transforming protein 1
Cytoplasm
Rap guanine nucleotide exchange factor 2
Protein kinase C complex
Interaction2393
B-cell antigen receptor complex-associated protein (Bos taurus) + B-cell receptor + Phosphate activates Tyrosine-protein kinase Lyn
Q08DN7
UniProt
O02742
UniProt
F1MDI4
UniProt
Interaction2398
Tyrosine-protein kinase SYK with Phosphate activates SHC-transforming protein 1 with phosphorylation
Reaction179086
false
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate + Water → Phosphatidylinositol 4,5-bisphosphate
LEFT_TO_RIGHT
Interaction2399
SHC-transforming protein 1 with phosphorylation activates GRB2/SOS complex
Reaction179084
false
Nuclear factor of activated T-cells (Bos taurus) + Phosphate → Nuclear factor of activated T-cells + Phosphate
LEFT_TO_RIGHT
7732-18-5
CAS
Interaction2394
Tyrosine-protein kinase Lyn activates Tyrosine-protein kinase SYK with Phosphate
Interaction2395
Tyrosine-protein kinase Lyn activates B-cell linker protein with Phosphate
Interaction2396
Tyrosine-protein kinase SYK with Phosphate activates B-cell linker protein with Phosphate
Interaction2397
Tyrosine-protein kinase SYK with Phosphate activates Proto-oncogene vav with Phosphate
ORAI calcium release-activated calcium modulator 1
RAF proto-oncogene serine/threonine-protein kinase
Reaction115852
false
Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate
LEFT_TO_RIGHT
439456
PubChem-compound
1.0
Ras-related protein Rap-1b
FOS,JUN Complex
B cell linker
HMDB0001498
HMDB
Protein kinase C beta type
A5PKA7
UniProt
F1MSG6
UniProt
Aurora kinase A
962
PubChem-compound
Ras-related C3 botulinum toxin substrate 1
C00076
KEGG Compound
Proto-oncogene vav
CA%2b2
BioCyc
Ca
Calcium
39.96259
HMDB0002111
HMDB
CHEBI:15377
ChEBI
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
14265-44-2
CAS
Transcription factor AP-1
271
PubChem-compound
Phosphate
CD79b molecule
1.0
Reaction115846
false
Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
LEFT_TO_RIGHT
P98201
UniProt
Calmodulin
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
P04409
UniProt
GRB2-related adapter protein
Q3ZBW9
UniProt
Q5E9X2
UniProt
PW122203
PathWhiz
H2O
Water
18.010565
1061
PubChem-compound
RAF proto-oncogene serine/threonine-protein kinase
Ras-related C3 botulinum toxin substrate 1
Nuclear factor of activated T-cells (Bos taurus)_Phosphate
Q2TA06
UniProt
1.0
Dual specificity mitogen-activated protein kinase kinase 6