Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Interaction2410
type: MolecularInteraction
interaction type: direct_interaction
name: Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Ras-related C3 botulinum toxin substrate 1
participant: Aurora kinase A

Interaction2411
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 8 without Magnesium
participant: Aurora kinase A
participant: Mitogen-activated protein kinase 13

Reference/UniProt F1MMQ7
type: UnificationXref
id: F1MMQ7
db: UniProt

B-cell receptor
type: Protein
cellular location: Cytoplasm
entity reference: B-cell receptor

Interaction2412
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 14 with Magnesium
participant: ORAI calcium release-activated calcium modulator 1
participant: Aurora kinase A

TransportCatalysis1449
type: Catalysis
controller: ORAI calcium release-activated calcium modulator 1
controlled: Transport10257
control type: ACTIVATION

direct_interaction
type: InteractionVocabulary

Interaction2413
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 14 with Magnesium activates FOS,JUN Complex
participant: ORAI calcium release-activated calcium modulator 1
participant: FOS,JUN Complex

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt Q2KJE6
type: UnificationXref
id: Q2KJE6
db: UniProt

Reference/UniProt Q2KIC2
type: UnificationXref
id: Q2KIC2
db: UniProt

Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9913
type: UnificationXref
id: 9913
db: TAXONOMY

Protein/19592 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
stoichiometric coefficient: 1.0

Reference/UniProt Q7YRP7
type: UnificationXref
id: Q7YRP7
db: UniProt

Mitogen-activated protein kinase 13
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 13

Interaction2400
type: MolecularInteraction
interaction type: direct_interaction
name: GRB2/SOS complex activates GTPase HRas with GTP
participant: GRB2/SOS complex
participant: Ras-related protein Rap-1b

Interaction2401
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates Tyrosine-protein kinase BTK with Phosphate
participant: Activated CDC42 kinase 1
participant: Tyrosine-protein kinase Fyn

Reference/UniProt Q309F2
type: UnificationXref
id: Q309F2
db: UniProt

CD79b molecule
type: ProteinReference
xref: Reference/UniProt F1MMQ7
organism: Bos taurus

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Interaction2406
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase with Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Ras-related protein Rap-1b

B-cell antigen receptor complex-associated protein alpha chain
type: ProteinReference
xref: Reference/UniProt Q28134
organism: Bos taurus

Interaction2407
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase with Phosphate activates Active Dual specificity mitogen-activated protein kinase kinase 1
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Dual specificity mitogen-activated protein kinase kinase 6

Interaction2408
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 3 with Phosphate activates FOS,JUN Complex
participant: Mitogen-activated protein kinase 1
participant: FOS,JUN Complex

Interaction2409
type: MolecularInteraction
interaction type: direct_interaction
name: Proto-oncogene vav with Phosphate activates Ras-related C3 botulinum toxin substrate 1
participant: Ras-related C3 botulinum toxin substrate 1
participant: Proto-oncogene vav

Interaction2402
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
participant: Activated CDC42 kinase 1

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Interaction2403
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C complex
participant: Protein kinase C complex
participant: Diacylglycerol

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 1

Interaction2404
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Protein kinase C complex
participant: Protein kinase C complex
participant: Calcium

Interaction2405
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates ETS domain-containing protein Elk-1
participant: Protein kinase C complex
participant: ETS translocation variant 1

Aurora kinase A
type: Protein
cellular location: Cytoplasm
entity reference: Aurora kinase A

GRB2/SOS complex
type: Complex
cellular location: Cytoplasm
component: Rap guanine nucleotide exchange factor 2
component: GRB2-related adapter protein

BCR Signaling Pathway
type: Pathway
pathway order: PathwayInteraction/2412
pathway order: PathwayInteraction/2413
pathway order: PathwayInteraction/2399
pathway order: PathwayInteraction/2410
pathway order: PathwayInteraction/2113
pathway order: PathwayInteraction/2411
pathway order: PathwayInteraction/2397
pathway order: PathwayInteraction/2398
pathway order: PathwayInteraction/2395
pathway order: PathwayInteraction/2396
pathway order: PathwayInteraction/2393
pathway order: PathwayInteraction/2394
pathway order: PathwayEnzymeReaction/2120534
pathway order: PathwayEnzymeReaction/2120533
pathway order: PathwayEnzymeReaction/2120532
pathway order: PathwayEnzymeReaction/2120531
pathway order: PathwayInteraction/2409
pathway order: PathwayInteraction/2407
pathway order: PathwayInteraction/2408
pathway order: PathwayInteraction/2405
pathway order: PathwayInteraction/2306
pathway order: PathwayInteraction/2406
pathway order: PathwayInteraction/2403
pathway order: PathwayInteraction/2404
pathway order: PathwayInteraction/2401
pathway order: PathwayInteraction/2324
pathway order: PathwayInteraction/2105
pathway order: PathwayInteraction/2402
pathway order: PathwayTransport/2120535
pathway order: PathwayInteraction/2400
pathway order: PathwayInteraction/2320
pathway order: PathwayInteraction/2321
pathway component: Interaction2393
pathway component: Interaction2398
pathway component: Reaction179086
pathway component: Interaction2399
pathway component: Interaction2410
pathway component: Interaction2113
pathway component: Interaction2411
pathway component: Reaction179084
pathway component: Interaction2412
pathway component: TransportCatalysis1449
pathway component: Interaction2394
pathway component: Interaction2395
pathway component: Interaction2396
pathway component: Interaction2397
pathway component: Reaction115852
pathway component: Interaction2413
pathway component: Interaction2321
pathway component: Interaction2400
pathway component: Interaction2401
pathway component: Interaction2324
pathway component: Transport10257
pathway component: Interaction2320
pathway component: Interaction2406
pathway component: Interaction2407
pathway component: Interaction2408
pathway component: Interaction2409
pathway component: Interaction2105
pathway component: Interaction2402
pathway component: Interaction2403
pathway component: Interaction2404
pathway component: Interaction2405
pathway component: Interaction2306
pathway component: Reaction115846
xref: Reference/PathWhiz PW122203
xref: Reference/SMPDB SMP0120940
organism: Bos taurus

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

B-cell antigen receptor complex-associated protein
type: Complex
cellular location: Cytoplasm
component: B-cell antigen receptor complex-associated protein alpha chain
component: CD79b molecule

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Rap guanine nucleotide exchange factor 2
type: ProteinReference
xref: Reference/UniProt F1MSG6
organism: Bos taurus

B-cell receptor
type: ProteinReference
organism: Bos taurus

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/UniProt A6QLK6
type: UnificationXref
id: A6QLK6
db: UniProt

B-cell antigen receptor complex-associated protein alpha chain
type: Protein
cellular location: Cytoplasm
entity reference: B-cell antigen receptor complex-associated protein alpha chain

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P04409
organism: Bos taurus

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Transport10257
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Bos taurus, Extracellular Space to Bos taurus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Nuclear factor of activated T-cells, cytoplasmic 1
type: ProteinReference
xref: Reference/UniProt P98201
organism: Bos taurus

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Interaction2306
type: MolecularInteraction
interaction type: direct_interaction
name: Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate
participant: Mitogen-activated protein kinase 1
participant: Dual specificity mitogen-activated protein kinase kinase 6

Proto-oncogene vav
type: ProteinReference
xref: Reference/UniProt Q08DN7
organism: Bos taurus

Tyrosine-protein kinase Fyn
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase Fyn

ORAI calcium release-activated calcium modulator 1
type: Protein
entity reference: ORAI calcium release-activated calcium modulator 1

Proto-oncogene c-Fos
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene c-Fos

B-cell antigen receptor complex-associated protein (Bos taurus)_B-cell receptor_Phosphate
type: Complex
component stoichiometry: Protein/Generic440 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12467 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: B-cell antigen receptor complex-associated protein
component: B-cell receptor
component: Phosphate

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inositol 1,4,5-trisphosphate

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: Reference/UniProt A0JNB0
organism: Bos taurus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: Reference/UniProt Q3T0N5
organism: Bos taurus

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Interaction2321
type: MolecularInteraction
interaction type: direct_interaction
name: Calmodulin(123) activates protein phosphatase 3
participant: Calmodulin
participant: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

ETS translocation variant 1
type: Protein
cellular location: Cytoplasm
entity reference: ETS translocation variant 1

Interaction2324
type: MolecularInteraction
interaction type: direct_interaction
name: protein phosphatase 3 activates Nuclear factor of activated T-cells (Bos taurus) + Phosphate
participant: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
participant: Nuclear factor of activated T-cells (Bos taurus)_Phosphate

Reference/UniProt Q3T0N5
type: UnificationXref
id: Q3T0N5
db: UniProt

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Interaction2320
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calmodulin(123)
participant: Calmodulin
participant: Calcium

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt O77627
organism: Bos taurus

ORAI calcium release-activated calcium modulator 1
type: Protein
cellular location: Cytoplasm
entity reference: ORAI calcium release-activated calcium modulator 1

Activated CDC42 kinase 1
type: ProteinReference
xref: Reference/UniProt O02742
organism: Bos taurus

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/UniProt O77627
type: UnificationXref
id: O77627
db: UniProt

ProteinComplex/12467 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: B-cell antigen receptor complex-associated protein
stoichiometric coefficient: 1.0

Reference/UniProt A7YY51
type: UnificationXref
id: A7YY51
db: UniProt

Interaction2113
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex
participant: Mitogen-activated protein kinase 13
participant: FOS,JUN Complex

Reference/UniProt Q3T0M4
type: UnificationXref
id: Q3T0M4
db: UniProt

Diacylglycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Diacylglycerol

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt P08487
organism: Bos taurus

Calmodulin
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin

SHC-transforming protein 1
type: Protein
cellular location: Cytoplasm
entity reference: SHC-transforming protein 1

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

GRB2-related adapter protein
type: Protein
cellular location: Cytoplasm
entity reference: GRB2-related adapter protein

BoundComplex/429 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells (Bos taurus)_Phosphate
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Ras-related protein Rap-1b
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related protein Rap-1b

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Interaction2105
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate
participant: Ras-related protein Rap-1b

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt A5D7N0
organism: Bos taurus

Activated CDC42 kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Activated CDC42 kinase 1

Reference/UniProt A5D7N0
type: UnificationXref
id: A5D7N0
db: UniProt

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Reference/UniProt Q45KX9
type: UnificationXref
id: Q45KX9
db: UniProt

Nuclear factor of activated T-cells, cytoplasmic 1
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor of activated T-cells, cytoplasmic 1

B cell linker
type: ProteinReference
xref: Reference/UniProt F1MDI4
organism: Bos taurus

Reference/UniProt A2VE60
type: UnificationXref
id: A2VE60
db: UniProt

Reference/SMPDB SMP0120940
type: UnificationXref
id: SMP0120940
db: SMPDB

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt A2VE60
organism: Bos taurus

Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Proto-oncogene c-Fos
type: ProteinReference
xref: Reference/UniProt Q7YRP7
organism: Bos taurus

Reference/UniProt P08487
type: UnificationXref
id: P08487
db: UniProt

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Protein/21129 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells, cytoplasmic 1
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt A0JNB0
type: UnificationXref
id: A0JNB0
db: UniProt

Bos taurus
type: BioSource
xref: Reference/TAXONOMY 9913

Reference/UniProt Q28134
type: UnificationXref
id: Q28134
db: UniProt

ETS translocation variant 1
type: ProteinReference
xref: Reference/UniProt Q2KIC2
organism: Bos taurus

SHC-transforming protein 1
type: ProteinReference
xref: Reference/UniProt Q45KX9
organism: Bos taurus

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cytoplasm
entity reference: Rap guanine nucleotide exchange factor 2

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C alpha type
component: Protein kinase C beta type

Interaction2393
type: MolecularInteraction
interaction type: direct_interaction
name: B-cell antigen receptor complex-associated protein (Bos taurus) + B-cell receptor + Phosphate activates Tyrosine-protein kinase Lyn
participant: B-cell antigen receptor complex-associated protein (Bos taurus)_B-cell receptor_Phosphate
participant: Tyrosine-protein kinase Fyn

Reference/UniProt Q08DN7
type: UnificationXref
id: Q08DN7
db: UniProt

Reference/UniProt O02742
type: UnificationXref
id: O02742
db: UniProt

Reference/UniProt F1MDI4
type: UnificationXref
id: F1MDI4
db: UniProt

Interaction2398
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates SHC-transforming protein 1 with phosphorylation
participant: SHC-transforming protein 1
participant: Activated CDC42 kinase 1

Reaction179086
type: BiochemicalReaction
participant stoichiometry: Protein/19592 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
right: Phosphatidylinositol 4,5-bisphosphate
spontaneous: false
left: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
left: Water
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate + Water → Phosphatidylinositol 4,5-bisphosphate
conversion direction: LEFT_TO_RIGHT

Interaction2399
type: MolecularInteraction
interaction type: direct_interaction
name: SHC-transforming protein 1 with phosphorylation activates GRB2/SOS complex
participant: GRB2/SOS complex
participant: SHC-transforming protein 1

Reaction179084
type: BiochemicalReaction
participant stoichiometry: BoundComplex/429 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/21129 Cytoplasm/Stoichiometry/1.0
right: Nuclear factor of activated T-cells, cytoplasmic 1
right: Phosphate
spontaneous: false
left: Nuclear factor of activated T-cells (Bos taurus)_Phosphate
name: Nuclear factor of activated T-cells (Bos taurus) + Phosphate → Nuclear factor of activated T-cells + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Interaction2394
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase Lyn activates Tyrosine-protein kinase SYK with Phosphate
participant: Activated CDC42 kinase 1
participant: Tyrosine-protein kinase Fyn

Interaction2395
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase Lyn activates B-cell linker protein with Phosphate
participant: Tyrosine-protein kinase Fyn
participant: B cell linker

Interaction2396
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates B-cell linker protein with Phosphate
participant: Activated CDC42 kinase 1
participant: B cell linker

Interaction2397
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates Proto-oncogene vav with Phosphate
participant: Activated CDC42 kinase 1
participant: Proto-oncogene vav

ORAI calcium release-activated calcium modulator 1
type: ProteinReference
xref: Reference/UniProt A5PKA7

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Reaction115852
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Protein/Generic440 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: B-cell receptor
stoichiometric coefficient: 1.0

Ras-related protein Rap-1b
type: ProteinReference
xref: Reference/UniProt Q3T0M4
organism: Bos taurus

FOS,JUN Complex
type: Complex
cellular location: Cytoplasm
component: Transcription factor AP-1
component: Proto-oncogene c-Fos

B cell linker
type: Protein
cellular location: Cytoplasm
entity reference: B cell linker

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Reference/UniProt A5PKA7
type: UnificationXref
id: A5PKA7
db: UniProt

Reference/UniProt F1MSG6
type: UnificationXref
id: F1MSG6
db: UniProt

Aurora kinase A
type: ProteinReference
xref: Reference/UniProt Q2TA06
organism: Bos taurus

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt Q3ZBW9
organism: Bos taurus

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Proto-oncogene vav
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene vav

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Transcription factor AP-1
type: Protein
cellular location: Cytoplasm
entity reference: Transcription factor AP-1

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

CD79b molecule
type: Protein
cellular location: Cytoplasm
entity reference: CD79b molecule

Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P98201
type: UnificationXref
id: P98201
db: UniProt

Calmodulin
type: ProteinReference
xref: Reference/UniProt Q2KJE6
organism: Bos taurus

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt Q309F2
organism: Bos taurus

Reference/UniProt P04409
type: UnificationXref
id: P04409
db: UniProt

GRB2-related adapter protein
type: ProteinReference
xref: Reference/UniProt A6QLK6
organism: Bos taurus

Reference/UniProt Q3ZBW9
type: UnificationXref
id: Q3ZBW9
db: UniProt

Reference/UniProt Q5E9X2
type: UnificationXref
id: Q5E9X2
db: UniProt

Reference/PathWhiz PW122203
type: UnificationXref
id: PW122203
db: PathWhiz

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt A7YY51
organism: Bos taurus

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related C3 botulinum toxin substrate 1

Nuclear factor of activated T-cells (Bos taurus)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21129 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Nuclear factor of activated T-cells, cytoplasmic 1
component: Phosphate

Reference/UniProt Q2TA06
type: UnificationXref
id: Q2TA06
db: UniProt

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt Q5E9X2
organism: Bos taurus