Reference/UniProt Q6UA68
type: UnificationXref
id: Q6UA68
db: UniProt

Reference/UniProt P49185
type: UnificationXref
id: P49185
db: UniProt

Protein/21084 Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Receptor tyrosine-protein kinase erbB-4
stoichiometric coefficient: 2.0

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/7758 Membrane/Stoichiometry/1.0
cellular location: Membrane
component: Unknown

Interaction2530
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Rattus norvegicus) + ELK1 (Rattus norvegicus) activates Glycoprotein hormones alpha chain
participant: Phosphate_Early growth response protein 1 (Rattus norvegicus)_ELK1 (Rattus norvegicus)
participant: Glycoprotein hormones alpha chain

Interaction2531
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Rattus norvegicus) + ELK1 (Rattus norvegicus) activates Follitropin subunit beta
participant: Follitropin subunit beta
participant: Phosphate_Early growth response protein 1 (Rattus norvegicus)_ELK1 (Rattus norvegicus)

Reference/UniProt P0DP31
type: UnificationXref
id: P0DP31
db: UniProt

Interaction2532
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 activates Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Rattus norvegicus)
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Rattus norvegicus)

Reference/UniProt Q9JID2
type: UnificationXref
id: Q9JID2
db: UniProt

Cyclic AMP-dependent transcription factor ATF-4
type: ProteinReference
xref: Reference/UniProt Q9ES19
organism: Rattus norvegicus

Interaction2533
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Rattus norvegicus) activates Phosphate + Mitogen-activated protein kinase 8 (Rattus norvegicus)
participant: Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Rattus norvegicus)
participant: Phosphate_Mitogen-activated protein kinase 8 (Rattus norvegicus)

Calmodulin-3
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin-3

Phosphate_Early growth response protein 1 (Rattus norvegicus)_ELK1 (Rattus norvegicus)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/19418 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/21890 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Early growth response protein 1
component: ETS domain-containing protein Elk-1

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Dual specificity mitogen-activated protein kinase kinase 7
type: Protein
cellular location: Nucleus
entity reference: Dual specificity mitogen-activated protein kinase kinase 7

direct_interaction
type: InteractionVocabulary

Interaction2534
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Mitogen-activated protein kinase 8 (Rattus norvegicus) activates Phosphate + Transcription factor AP-1 (Rattus norvegicus)
participant: Phosphate_Transcription factor AP-1 (Rattus norvegicus)
participant: Phosphate_Mitogen-activated protein kinase 8 (Rattus norvegicus)

Interaction2535
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Rattus norvegicus) activates Lutropin subunit beta
participant: Phosphate_Transcription factor AP-1 (Rattus norvegicus)
participant: Lutropin subunit beta

Interaction2536
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Rattus norvegicus) activates Glycoprotein hormones alpha chain
participant: Phosphate_Transcription factor AP-1 (Rattus norvegicus)
participant: Glycoprotein hormones alpha chain

Interaction2537
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Transcription factor AP-1 (Rattus norvegicus) activates Follitropin subunit beta
participant: Phosphate_Transcription factor AP-1 (Rattus norvegicus)
participant: Follitropin subunit beta

MMP2-MMP14
type: Complex
cellular location: Extracellular Space
component: 72 kDa type IV collagenase
component: Matrix metalloproteinase-14

Reference/UniProt Q9JI42
type: UnificationXref
id: Q9JI42
db: UniProt

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt P10687
organism: Rattus norvegicus

Follitropin subunit beta
type: Protein
cellular location: Nucleus
entity reference: Follitropin subunit beta

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q62869
organism: Rattus norvegicus

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/21084 Membrane/Stoichiometry/2.0
cellular location: Membrane
component: Receptor tyrosine-protein kinase erbB-4

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Interaction2520
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus) + Phosphate activates Lutropin subunit beta
participant: Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus)_Phosphate
participant: Lutropin subunit beta

Protein/21455 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic AMP-dependent transcription factor ATF-4
stoichiometric coefficient: 1.0

Interaction2521
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus) + Phosphate activates Glycoprotein hormones alpha chain
participant: Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus)_Phosphate
participant: Glycoprotein hormones alpha chain

Interaction2522
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 2 activates Dual specificity mitogen-activated protein kinase kinase 3 (Rattus norvegicus) + Phosphate
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Dual specificity mitogen-activated protein kinase kinase 3 (Rattus norvegicus)_Phosphate

Reference/UniProt Q5EBD5
type: UnificationXref
id: Q5EBD5
db: UniProt

Interaction2527
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 1 (Rattus norvegicus) + Phosphate activates Phosphate + Mitogen-activated protein kinase 1 (Rattus norvegicus)
participant: Dual specificity mitogen-activated protein kinase kinase 1 (Rattus norvegicus)_Phosphate
participant: Phosphate_Mitogen-activated protein kinase 1 (Rattus norvegicus)

Interaction2528
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Mitogen-activated protein kinase 1 (Rattus norvegicus) activates Phosphate + Early growth response protein 1 (Rattus norvegicus) + ELK1 (Rattus norvegicus)
participant: Phosphate_Mitogen-activated protein kinase 1 (Rattus norvegicus)
participant: Phosphate_Early growth response protein 1 (Rattus norvegicus)_ELK1 (Rattus norvegicus)

Interaction2529
type: MolecularInteraction
interaction type: direct_interaction
name: Phosphate + Early growth response protein 1 (Rattus norvegicus) + ELK1 (Rattus norvegicus) activates Lutropin subunit beta
participant: Lutropin subunit beta
participant: Phosphate_Early growth response protein 1 (Rattus norvegicus)_ELK1 (Rattus norvegicus)

Protein/7758 Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Interaction2523
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 3 (Rattus norvegicus) + Phosphate activates Mitogen-activated protein kinase 14 (Rattus norvegicus) + Phosphate
participant: Mitogen-activated protein kinase 14 (Rattus norvegicus)_Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 3 (Rattus norvegicus)_Phosphate

Interaction2524
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates RAF proto-oncogene serine/threonine-protein kinase (Rattus norvegicus) + Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase (Rattus norvegicus)_Phosphate
participant: Protein kinase C complex

Interaction2525
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase (Rattus norvegicus) + Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase (Rattus norvegicus)_Phosphate
participant: GTPase HRas

Interaction2526
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase (Rattus norvegicus) + Phosphate activates Dual specificity mitogen-activated protein kinase kinase 1 (Rattus norvegicus) + Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 1 (Rattus norvegicus)_Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase (Rattus norvegicus)_Phosphate

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Leucine-rich repeat-containing protein 7
type: Protein
cellular location: Cytoplasm
entity reference: Leucine-rich repeat-containing protein 7

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 1

Alpha-actinin-4
type: Protein
cellular location: Cytoplasm
entity reference: Alpha-actinin-4

Transport10264
type: Transport
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Rattus norvegicus, Cell, Endoplasmic Reticulum to Rattus norvegicus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Protein/19418 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: ETS domain-containing protein Elk-1
stoichiometric coefficient: 1.0

Protein/19450 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 7
stoichiometric coefficient: 1.0

Protein/21890 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Early growth response protein 1
stoichiometric coefficient: 1.0

Reference/UniProt P50393
type: UnificationXref
id: P50393
db: UniProt

Reference/UniProt Q9QWJ6
type: UnificationXref
id: Q9QWJ6
db: UniProt

Reference/UniProt P01230
type: UnificationXref
id: P01230
db: UniProt

Reference/UniProt Q06175
type: UnificationXref
id: Q06175
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Protein/19639 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 1
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Reference/UniProt P11275
type: UnificationXref
id: P11275
db: UniProt

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt P68403
organism: Rattus norvegicus

GnRH Signaling Pathway
type: Pathway
pathway order: PathwayInteraction/2519
pathway order: PathwayInteraction/2517
pathway order: PathwayInteraction/2518
pathway order: PathwayInteraction/2515
pathway order: PathwayInteraction/2537
pathway order: PathwayInteraction/2516
pathway order: PathwayInteraction/2513
pathway order: PathwayInteraction/2535
pathway order: PathwayInteraction/2514
pathway order: PathwayInteraction/2536
pathway order: PathwayInteraction/2511
pathway order: PathwayInteraction/2533
pathway order: PathwayInteraction/2512
pathway order: PathwayInteraction/2534
pathway order: PathwayInteraction/2498
pathway order: PathwayInteraction/2531
pathway order: PathwayInteraction/2499
pathway order: PathwayInteraction/2510
pathway order: PathwayInteraction/2532
pathway order: PathwayInteraction/2496
pathway order: PathwayInteraction/2497
pathway order: PathwayInteraction/2530
pathway order: PathwayInteraction/2495
pathway order: PathwayInteraction/2490
pathway order: PathwayInteraction/2508
pathway order: PathwayInteraction/2509
pathway order: PathwayInteraction/2506
pathway order: PathwayInteraction/2528
pathway order: PathwayInteraction/2507
pathway order: PathwayInteraction/2529
pathway order: PathwayInteraction/2504
pathway order: PathwayInteraction/2526
pathway order: PathwayInteraction/2505
pathway order: PathwayInteraction/2527
pathway order: PathwayInteraction/2502
pathway order: PathwayInteraction/2524
pathway order: PathwayInteraction/2503
pathway order: PathwayInteraction/2525
pathway order: PathwayInteraction/2500
pathway order: PathwayInteraction/2522
pathway order: PathwayInteraction/2501
pathway order: PathwayInteraction/2523
pathway order: PathwayInteraction/2520
pathway order: PathwayInteraction/2521
pathway order: PathwayTransport/2120675
pathway order: PathwayInteraction/2462
pathway component: Interaction2490
pathway component: Interaction2497
pathway component: Interaction2530
pathway component: Interaction2498
pathway component: Interaction2531
pathway component: Interaction2499
pathway component: Interaction2510
pathway component: Interaction2532
pathway component: Interaction2511
pathway component: Interaction2533
pathway component: Interaction2495
pathway component: Interaction2496
pathway component: Interaction2516
pathway component: Interaction2517
pathway component: Transport10264
pathway component: Interaction2518
pathway component: Interaction2519
pathway component: Interaction2512
pathway component: Interaction2534
pathway component: Interaction2513
pathway component: Interaction2535
pathway component: Interaction2514
pathway component: Interaction2536
pathway component: Interaction2515
pathway component: Interaction2537
pathway component: Interaction2520
pathway component: Interaction2521
pathway component: Interaction2500
pathway component: Interaction2522
pathway component: Interaction2462
pathway component: Interaction2505
pathway component: Interaction2527
pathway component: Interaction2506

Adenylate cyclase type 5
type: ProteinReference
xref: Reference/UniProt Q04400
organism: Rattus norvegicus

Reference/UniProt Q5BKA7
type: UnificationXref
id: Q5BKA7
db: UniProt

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P05696
organism: Rattus norvegicus

Glycoprotein hormones alpha chain
type: Protein
cellular location: Nucleus
entity reference: Glycoprotein hormones alpha chain

Reference/UniProt P28818
type: UnificationXref
id: P28818
db: UniProt

Phosphate_Mitogen-activated protein kinase 1 (Rattus norvegicus)
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19414 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Phosphate
component: Mitogen-activated protein kinase 1

Cytosolic phospholipase A2
type: Protein
cellular location: Cytoplasm
entity reference: Cytosolic phospholipase A2

Protein/22030 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leucine-rich repeat-containing protein 7
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Membrane
entity reference: Unknown

Protein/19410 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Early growth response protein 1
type: ProteinReference
xref: Reference/UniProt Q53YM5
organism: Rattus norvegicus

DG
type: SmallMoleculeReference

Ternary complex (LRRC7, CAMK2a, ACTN4)
type: Complex
component stoichiometry: Protein/22024 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22030 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21980 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Alpha-actinin-4
component: Leucine-rich repeat-containing protein 7
component: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: Reference/UniProt Q4KSH7
organism: Rattus norvegicus

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Proto-oncogene tyrosine-protein kinase Src
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene tyrosine-protein kinase Src

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P49185
organism: Rattus norvegicus

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Phosphate_Mitogen-activated protein kinase 8 (Rattus norvegicus)
type: Complex
component stoichiometry: Protein/19454 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Mitogen-activated protein kinase 8
component: Phosphate

Reference/UniProt Q6IN06
type: UnificationXref
id: Q6IN06
db: UniProt

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/21455 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Cyclic AMP-dependent transcription factor ATF-4
component: Phosphate

Reference/UniProt P05696
type: UnificationXref
id: P05696
db: UniProt

Proheparin-binding EGF-like growth factor
type: ProteinReference
xref: Reference/UniProt Q06175
organism: Rattus norvegicus

Proheparin-binding EGF-like growth factor
type: Protein
cellular location: Extracellular Space
entity reference: Proheparin-binding EGF-like growth factor

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt Q5RJJ8
type: UnificationXref
id: Q5RJJ8
db: UniProt

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Mitogen-activated protein kinase 14
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 14

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt P17325
organism: Rattus norvegicus

Reference/UniProt Q71TW5
type: UnificationXref
id: Q71TW5
db: UniProt

Protein kinase C complex
type: Complex
cellular location: Membrane
component: Protein kinase C alpha type
component: Protein kinase C beta type

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Mitogen-activated protein kinase 1
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 1

Protein/19470 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 14
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Gonadotropin-releasing hormone receptor
type: Protein
cellular location: Cell Membrane
entity reference: Gonadotropin-releasing hormone receptor

Reference/UniProt P11345
type: UnificationXref
id: P11345
db: UniProt

Protein kinase C alpha type
type: Protein
cellular location: Membrane
entity reference: Protein kinase C alpha type

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Nucleus
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

72 kDa type IV collagenase
type: ProteinReference
xref: Reference/UniProt Q6GMM9
organism: Rattus norvegicus

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Mitogen-activated protein kinase 14
type: ProteinReference
xref: Reference/UniProt Q99MG4
organism: Rattus norvegicus

Protein/19454 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 8
stoichiometric coefficient: 1.0

Reference/UniProt P17325
type: UnificationXref
id: P17325
db: UniProt

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

72 kDa type IV collagenase
type: Protein
cellular location: Extracellular Space
entity reference: 72 kDa type IV collagenase

Cell division control protein 42 homolog
type: Protein
cellular location: Cytoplasm
entity reference: Cell division control protein 42 homolog

Dual specificity mitogen-activated protein kinase kinase 1 (Rattus norvegicus)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19639 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Dual specificity mitogen-activated protein kinase kinase 1
component: Phosphate

DG
type: SmallMolecule
cellular location: Cytoplasm
entity reference: DG

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Reference/UniProt Q9ES19
type: UnificationXref
id: Q9ES19
db: UniProt

Reference/UniProt P18427
type: UnificationXref
id: P18427
db: UniProt

Matrix metalloproteinase-14
type: ProteinReference
xref: Reference/UniProt Q6IN06
organism: Rattus norvegicus

Interaction2462
type: MolecularInteraction
interaction type: direct_interaction
name: Growth factor receptor-bound protein 2 activates Son of sevenless homolog 1
participant: Growth factor receptor-bound protein 2
participant: Ras-specific guanine nucleotide-releasing factor 1

Phosphate_Mitogen-activated protein kinase 1 (Rattus norvegicus)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/19414 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Mitogen-activated protein kinase 1

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/UniProt P70516
type: UnificationXref
id: P70516
db: UniProt

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Receptor tyrosine-protein kinase erbB-4
type: Protein
cellular location: Cytoplasm
entity reference: Receptor tyrosine-protein kinase erbB-4

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Protein/21084 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Receptor tyrosine-protein kinase erbB-4
stoichiometric coefficient: 2.0

Arachidonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Arachidonic acid

Reference/UniProt Q9JJ10
type: UnificationXref
id: Q9JJ10
db: UniProt

Protein kinase C beta type
type: Protein
cellular location: Membrane
entity reference: Protein kinase C beta type

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Interaction2490
type: MolecularInteraction
interaction type: direct_interaction
name: Epidermal growth factor receptor activates Growth factor receptor-bound protein 2
participant: Growth factor receptor-bound protein 2
participant: Epidermal growth factor receptor

Mitogen-activated protein kinase 8
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 8

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Interaction2497
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP

Interaction2498
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein subunit alpha-11 activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: Guanine nucleotide-binding protein subunit alpha-11

Interaction2499
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates IP3
participant: IP3
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Interaction2495
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Adenylate cyclase type 1
participant: Adenylate cyclase type 5
participant: Unknown

Reference/UniProt P30969
type: UnificationXref
id: P30969
db: UniProt

Interaction2496
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylate cyclase type 1 activates cAMP
participant: Adenylate cyclase type 5
participant: cAMP

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: ProteinReference
xref: Reference/UniProt P11275
organism: Rattus norvegicus

Reference/UniProt P63086
type: UnificationXref
id: P63086
db: UniProt

Reference/UniProt Q99MG4
type: UnificationXref
id: Q99MG4
db: UniProt

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P11345
organism: Rattus norvegicus

IP3
type: SmallMoleculeReference

Dual specificity mitogen-activated protein kinase kinase 7
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 7

Phosphatidic Acid
type: SmallMoleculeReference

Glycoprotein hormones alpha chain
type: ProteinReference
xref: Reference/UniProt P70516
organism: Rattus norvegicus

Mitogen-activated protein kinase 14 (Rattus norvegicus)_Phosphate
type: Complex
component stoichiometry: Protein/19470 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase 14
component: Phosphate

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P63086
organism: Rattus norvegicus

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Follitropin subunit beta
type: ProteinReference
xref: Reference/UniProt P18427
organism: Rattus norvegicus

Reference/SMPDB SMP0120949
type: UnificationXref
id: SMP0120949
db: SMPDB

ETS domain-containing protein Elk-1
type: ProteinReference
xref: Reference/UniProt A4GTP4
organism: Rattus norvegicus

Reference/UniProt P10687
type: UnificationXref
id: P10687
db: UniProt

Phosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Phosphate

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

Reference/UniProt Q4KSH7
type: UnificationXref
id: Q4KSH7
db: UniProt

Protein/19461 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcription factor AP-1
stoichiometric coefficient: 1.0

Gonadotropin-releasing hormone receptor
type: ProteinReference
xref: Reference/UniProt P30969
organism: Rattus norvegicus

Protein/19708 Endoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Leucine-rich repeat-containing protein 7
type: ProteinReference
xref: Reference/UniProt Q9JI42
organism: Rattus norvegicus

Lutropin subunit beta
type: ProteinReference
xref: Reference/UniProt P01230
organism: Rattus norvegicus

Alpha-actinin-4
type: ProteinReference
xref: Reference/UniProt Q6P786
organism: Rattus norvegicus

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

GTPase HRas
type: ProteinReference
xref: Reference/UniProt Q5RJJ8
organism: Rattus norvegicus

Progonadoliberin-1
type: ProteinReference
xref: Reference/UniProt P07490
organism: Rattus norvegicus

Progonadoliberin-1
type: Protein
cellular location: Cell Membrane
entity reference: Progonadoliberin-1

RAF proto-oncogene serine/threonine-protein kinase (Rattus norvegicus)_Phosphate
type: Complex
component stoichiometry: Protein/19410 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: RAF proto-oncogene serine/threonine-protein kinase
component: Phosphate

Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Rattus norvegicus)
type: Complex
component stoichiometry: Protein/19450 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Dual specificity mitogen-activated protein kinase kinase 7

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Receptor tyrosine-protein kinase erbB-4
type: Protein
cellular location: Membrane
entity reference: Receptor tyrosine-protein kinase erbB-4

Reference/UniProt Q62869
type: UnificationXref
id: Q62869
db: UniProt

Phosphatidic Acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphatidic Acid

Reference/UniProt P68403
type: UnificationXref
id: P68403
db: UniProt

Reference/UniProt Q9Z2N7
type: UnificationXref
id: Q9Z2N7
db: UniProt

Cell division control protein 42 homolog
type: ProteinReference
xref: Reference/UniProt Q71TW5
organism: Rattus norvegicus

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19708 Endoplasmic Reticulum/Stoichiometry/4.0
cellular location: Endoplasmic Reticulum
component: Inositol 1,4,5-trisphosphate receptor type 1

Proheparin-binding EGF-like growth factor
type: Protein
cellular location: Membrane
entity reference: Proheparin-binding EGF-like growth factor

Adenylate cyclase type 5
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 5

Protein/21980 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Alpha-actinin-4
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Protein/19414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Lutropin subunit beta
type: Protein
cellular location: Nucleus
entity reference: Lutropin subunit beta

Protein/19450 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 7
stoichiometric coefficient: 1.0

IP3
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: IP3

Reference/GENE ONTOLOGY GO 0016020
type: UnificationXref
id: GO:0016020
db: GENE ONTOLOGY

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Receptor tyrosine-protein kinase erbB-4
type: ProteinReference
xref: Reference/UniProt Q9Z2N7
organism: Rattus norvegicus

Protein/22024 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium/calmodulin-dependent protein kinase type II subunit alpha
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q62925
organism: Rattus norvegicus

Cytosolic phospholipase A2
type: ProteinReference
xref: Reference/UniProt P50393
organism: Rattus norvegicus

Protein/19414 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Guanine nucleotide-binding protein subunit alpha-11
type: Protein
cellular location: Cytoplasm
entity reference: Guanine nucleotide-binding protein subunit alpha-11

Epidermal growth factor receptor
type: Complex
component stoichiometry: Protein/21084 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Receptor tyrosine-protein kinase erbB-4

Reference/UniProt Q62925
type: UnificationXref
id: Q62925
db: UniProt

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

ETS domain-containing protein Elk-1
type: Protein
cellular location: Nucleus
entity reference: ETS domain-containing protein Elk-1

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Matrix metalloproteinase-14
type: Protein
cellular location: Extracellular Space
entity reference: Matrix metalloproteinase-14

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Calcium
type: SmallMolecule
cellular location: Membrane
entity reference: Calcium

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP31
organism: Rattus norvegicus

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C beta type
component: Protein kinase C alpha type

Growth factor receptor-bound protein 2
type: ProteinReference
xref: Reference/UniProt Q5BKA7
organism: Rattus norvegicus

Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016020

Phosphate_Transcription factor AP-1 (Rattus norvegicus)
type: Complex
component stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/19461 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Phosphate
component: Transcription factor AP-1

Reference/UniProt A4GTP4
type: UnificationXref
id: A4GTP4
db: UniProt

Unknown
type: ProteinReference
organism: Rattus norvegicus

Growth factor receptor-bound protein 2
type: Protein
cellular location: Cytoplasm
entity reference: Growth factor receptor-bound protein 2

Interaction2510
type: MolecularInteraction
interaction type: direct_interaction
name: Son of sevenless homolog 1 activates GTPase HRas
participant: GTPase HRas
participant: Ras-specific guanine nucleotide-releasing factor 1

Interaction2511
type: MolecularInteraction
interaction type: direct_interaction
name: Cytosolic phospholipase A2 beta activates Arachidonic acid
participant: Cytosolic phospholipase A2
participant: Arachidonic acid

Interaction2516
type: MolecularInteraction
interaction type: direct_interaction
name: Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein subunit alpha-11
participant: Gonadotropin-releasing hormone receptor
participant: Guanine nucleotide-binding protein subunit alpha-11

Interaction2517
type: MolecularInteraction
interaction type: direct_interaction
name: Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein alpha
participant: Gonadotropin-releasing hormone receptor
participant: Unknown

Interaction2518
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP-dependent protein kinase catalytic subunit alpha activates Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus) + Phosphate
participant: Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus)_Phosphate
participant: cAMP-dependent protein kinase catalytic subunit alpha

Interaction2519
type: MolecularInteraction
interaction type: direct_interaction
name: Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus) + Phosphate activates Follitropin subunit beta
participant: Follitropin subunit beta
participant: Cyclic AMP-dependent transcription factor ATF-4 (Rattus norvegicus)_Phosphate

Interaction2512
type: MolecularInteraction
interaction type: direct_interaction
name: Phospholipase D1 activates Phosphatidic Acid
participant: Phospholipase D1
participant: Phosphatidic Acid

Cyclic AMP-dependent transcription factor ATF-4
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-dependent transcription factor ATF-4

Interaction2513
type: MolecularInteraction
interaction type: direct_interaction
name: Proto-oncogene tyrosine-protein kinase Src activates Cell division control protein 42 homolog
participant: Proto-oncogene tyrosine-protein kinase Src
participant: Cell division control protein 42 homolog

Interaction2514
type: MolecularInteraction
interaction type: direct_interaction
name: Cell division control protein 42 homolog activates Mitogen-activated protein kinase kinase kinase 1
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Cell division control protein 42 homolog

Interaction2515
type: MolecularInteraction
interaction type: direct_interaction
name: Progonadoliberin-1 activates Gonadotropin-releasing hormone receptor
participant: Progonadoliberin-1
participant: Gonadotropin-releasing hormone receptor

Reference/UniProt Q6P786
type: UnificationXref
id: Q6P786
db: UniProt

Reference/UniProt Q6GMM9
type: UnificationXref
id: Q6GMM9
db: UniProt

Ras-specific guanine nucleotide-releasing factor 1
type: ProteinReference
xref: Reference/UniProt P28818
organism: Rattus norvegicus

Phospholipase D1
type: ProteinReference
xref: Reference/UniProt Q9QWJ6
organism: Rattus norvegicus

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt Q6UA68
organism: Rattus norvegicus

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q5EBD5
organism: Rattus norvegicus

Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Rattus norvegicus)
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19450 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Dual specificity mitogen-activated protein kinase kinase 7
component: Phosphate

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Compound/PW C001104 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Calcium

Reference/UniProt Q53YM5
type: UnificationXref
id: Q53YM5
db: UniProt

Early growth response protein 1
type: Protein
cellular location: Nucleus
entity reference: Early growth response protein 1

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: Reference/UniProt Q9JJ10
organism: Rattus norvegicus

Interaction2500
type: MolecularInteraction
interaction type: direct_interaction
name: IP3 activates Inositol 1,4,5-trisphosphate receptor type 1
participant: IP3
participant: Inositol 1,4,5-trisphosphate receptor type 1

Ras-specific guanine nucleotide-releasing factor 1
type: Protein
cellular location: Cytoplasm
entity reference: Ras-specific guanine nucleotide-releasing factor 1

Compound/PW C000353 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P07490
type: UnificationXref
id: P07490
db: UniProt

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: Reference/UniProt Q9JID2
organism: Rattus norvegicus

Interaction2505
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Voltage-dependent L-type calcium channel
participant: Calcium
participant: Unknown

Interaction2506
type: MolecularInteraction
interaction type: direct_interaction
name: Voltage-dependent L-type calcium channel activates Protein kinase C complex
participant: Protein kinase C complex
participant: Unknown

Reference/UniProt Q04400
type: UnificationXref
id: Q04400
db: UniProt

IP3
type: SmallMolecule
cellular location: Cytoplasm
entity reference: IP3

Interaction2507
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates Voltage-depenent L-type calcium channel
participant: Protein kinase C complex
participant: Voltage-depenent L-type calcium channel

Interaction2508
type: MolecularInteraction
interaction type: direct_interaction
name: MMP2-MMP14 activates Proheparin-binding EGF-like growth factor
participant: Proheparin-binding EGF-like growth factor
participant: MMP2-MMP14

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Interaction2501
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calmodulin-like protein 6
participant: Calcium
participant: Calmodulin-3

Interaction2502
type: MolecularInteraction
interaction type: direct_interaction
name: Calmodulin-like protein 6 activates Ternary complex (LRRC7, CAMK2a, ACTN4)
participant: Ternary complex (LRRC7, CAMK2a, ACTN4)
participant: Calmodulin-3

Reference/PathWhiz PW122212
type: UnificationXref
id: PW122212
db: PathWhiz

Interaction2503
type: MolecularInteraction
interaction type: direct_interaction
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates DG
participant: DG
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Interaction2504
type: MolecularInteraction
interaction type: direct_interaction
name: DG activates Protein kinase C complex
participant: DG
participant: Protein kinase C complex

Phospholipase D1
type: Protein
cellular location: Cytoplasm
entity reference: Phospholipase D1

Gonadotropin-releasing hormone receptor
type: Protein
cellular location: Cytoplasm
entity reference: Gonadotropin-releasing hormone receptor

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Interaction2509
type: MolecularInteraction
interaction type: direct_interaction
name: Proheparin-binding EGF-like growth factor activates Epidermal growth factor receptor
participant: Proheparin-binding EGF-like growth factor
participant: Epidermal growth factor receptor

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

Dual specificity mitogen-activated protein kinase kinase 3 (Rattus norvegicus)_Phosphate
type: Complex
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19450 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Dual specificity mitogen-activated protein kinase kinase 7
component: Phosphate