Reference/UniProt P49185
type: UnificationXref
id: P49185
db: UniProt

Nuclear factor of activated T-cells 5
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor of activated T-cells 5

BCR Signaling Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2121015
pathway order: PathwayEnzymeReaction/2121014
pathway order: PathwayEnzymeReaction/2121013
pathway order: PathwayEnzymeReaction/2121012
pathway order: PathwayInteraction/2779
pathway order: PathwayInteraction/2777
pathway order: PathwayInteraction/2778
pathway order: PathwayInteraction/2679
pathway order: PathwayInteraction/2775
pathway order: PathwayInteraction/2776
pathway order: PathwayInteraction/2773
pathway order: PathwayInteraction/2477
pathway order: PathwayInteraction/2774
pathway order: PathwayInteraction/2697
pathway order: PathwayInteraction/2771
pathway order: PathwayInteraction/2694
pathway order: PathwayInteraction/2772
pathway order: PathwayTransport/2121016
pathway order: PathwayInteraction/2770
pathway order: PathwayInteraction/2693
pathway order: PathwayInteraction/2768
pathway order: PathwayInteraction/2769
pathway order: PathwayInteraction/2766
pathway order: PathwayInteraction/2767
pathway order: PathwayInteraction/2786
pathway order: PathwayInteraction/2784
pathway order: PathwayInteraction/2785
pathway order: PathwayInteraction/2782
pathway order: PathwayInteraction/2485
pathway order: PathwayInteraction/2783
pathway order: PathwayInteraction/2780
pathway order: PathwayInteraction/2781
pathway component: Interaction2772
pathway component: Interaction2773
pathway component: Interaction2477
pathway component: Interaction2774
pathway component: Interaction2697
pathway component: Interaction2775
pathway component: Reaction179124
pathway component: Reaction179122
pathway component: Interaction2770
pathway component: Interaction2693
pathway component: Interaction2771
pathway component: Interaction2694
pathway component: Reaction115852
pathway component: Interaction2776
pathway component: Interaction2777
pathway component: Interaction2778
pathway component: Interaction2679
pathway component: Interaction2779
pathway component: TransportCatalysis1452
pathway component: Interaction2783
pathway component: Interaction2784
pathway component: Interaction2785
pathway component: Interaction2786
pathway component: Interaction2780
pathway component: Interaction2781
pathway component: Interaction2782
pathway component: Interaction2485
pathway component: Interaction2769
pathway component: Interaction2766
pathway component: Transport10271
pathway component: Interaction2767
pathway component: Interaction2768
pathway component: Reaction115846
xref: Reference/PathWhiz PW122227
xref: Reference/SMPDB SMP0120964
organism: Rattus norvegicus

Interaction2772
type: MolecularInteraction
interaction type: direct_interaction
name: SHC-transforming protein 1 with phosphorylation activates GRB2/SOS complex
participant: SHC-transforming protein 1
participant: GRB2/SOS complex

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Interaction2773
type: MolecularInteraction
interaction type: direct_interaction
name: GRB2/SOS complex activates GTPase HRas with GTP
participant: GTPase HRas
participant: GRB2/SOS complex

Interaction2774
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates Tyrosine-protein kinase BTK with Phosphate
participant: Tyrosine-protein kinase SYK
participant: Proto-oncogene tyrosine-protein kinase LCK

Reference/UniProt P0DP31
type: UnificationXref
id: P0DP31
db: UniProt

B-cell receptor
type: Protein
cellular location: Cytoplasm
entity reference: B-cell receptor

Interaction2775
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
participant: Tyrosine-protein kinase SYK

Proto-oncogene tyrosine-protein kinase LCK
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene tyrosine-protein kinase LCK

Calmodulin-3
type: Protein
cellular location: Cytoplasm
entity reference: Calmodulin-3

Interaction2770
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates Proto-oncogene vav with Phosphate
participant: Proto-oncogene vav
participant: Tyrosine-protein kinase SYK

Interaction2771
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates SHC-transforming protein 1 with phosphorylation
participant: SHC-transforming protein 1
participant: Tyrosine-protein kinase SYK

direct_interaction
type: InteractionVocabulary

BoundComplex/480 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells (Rattus norvegicus)_Phosphate
stoichiometric coefficient: 1.0

Interaction2776
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C complex
participant: Diacylglycerol
participant: Protein kinase C complex

Interaction2777
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Protein kinase C complex
participant: Calcium
participant: Protein kinase C complex

Interaction2778
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates ETS domain-containing protein Elk-1
participant: ETS domain-containing protein Elk-1
participant: Protein kinase C complex

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Interaction2779
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase with Phosphate
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: GTPase HRas

Reference/UniProt B1H265
type: UnificationXref
id: B1H265
db: UniProt

Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

TransportCatalysis1452
type: Catalysis
controller: Calcium release-activated calcium channel protein 1
controlled: Transport10271
control type: ACTIVATION

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Tyrosine-protein kinase Lyn
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase Lyn

B29/Ig-beta/CD79b
type: ProteinReference
xref: Reference/UniProt F1MAP5
organism: Rattus norvegicus

Reference/UniProt Q5EBD5
type: UnificationXref
id: Q5EBD5
db: UniProt

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Interaction2769
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase SYK with Phosphate activates B-cell linker protein with Phosphate
participant: B-cell linker protein
participant: Tyrosine-protein kinase SYK

SHC-transforming protein 1
type: Protein
cellular location: Cytoplasm
entity reference: SHC-transforming protein 1

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt F1MAC3
organism: Rattus norvegicus

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Interaction2766
type: MolecularInteraction
interaction type: direct_interaction
name: B-cell antigen receptor complex-associated protein (Rattus norvegicus) + B-cell receptor + Phosphate activates Tyrosine-protein kinase Lyn
participant: Tyrosine-protein kinase Lyn
participant: B-cell antigen receptor complex-associated protein (Rattus norvegicus)_B-cell receptor_Phosphate

Transport10271
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Interaction2767
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase Lyn activates Tyrosine-protein kinase SYK with Phosphate
participant: Tyrosine-protein kinase SYK
participant: Tyrosine-protein kinase Lyn

Interaction2768
type: MolecularInteraction
interaction type: direct_interaction
name: Tyrosine-protein kinase Lyn activates B-cell linker protein with Phosphate
participant: B-cell linker protein
participant: Tyrosine-protein kinase Lyn

B-cell antigen receptor complex-associated protein (Rattus norvegicus)_B-cell receptor_Phosphate
type: Complex
component stoichiometry: Protein/Generic440 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12685 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: B-cell antigen receptor complex-associated protein
component: B-cell receptor
component: Phosphate

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Nuclear factor of activated T-cells (Rattus norvegicus)_Phosphate
type: Complex
component stoichiometry: Protein/21130 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Nuclear factor of activated T-cells 5
component: Phosphate

Protein kinase C alpha type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C alpha type

Reaction179124
type: BiochemicalReaction
participant stoichiometry: Protein/19593 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
right: Phosphatidylinositol 4,5-bisphosphate
spontaneous: false
left: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
left: Water
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 with phosphate + Water → Phosphatidylinositol 4,5-bisphosphate
conversion direction: LEFT_TO_RIGHT

Reaction179122
type: BiochemicalReaction
participant stoichiometry: Protein/21130 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/480 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
right: Nuclear factor of activated T-cells 5
right: Phosphate
spontaneous: false
left: Nuclear factor of activated T-cells (Rattus norvegicus)_Phosphate
name: Nuclear factor of activated T-cells (Rattus norvegicus) + Phosphate → Nuclear factor of activated T-cells + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/UniProt Q4KM52
type: UnificationXref
id: Q4KM52
db: UniProt

B-cell receptor
type: ProteinReference
organism: Rattus norvegicus

Interaction2679
type: MolecularInteraction
interaction type: direct_interaction
name: Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate
participant: Mitogen-activated protein kinase 3
participant: Dual specificity mitogen-activated protein kinase kinase 1

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Reference/UniProt Q63320
type: UnificationXref
id: Q63320
db: UniProt

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q6LDJ7
type: UnificationXref
id: Q6LDJ7
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Interaction2783
type: MolecularInteraction
interaction type: direct_interaction
name: Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Ras-related C3 botulinum toxin substrate 1

Interaction2784
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 8 without Magnesium
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Mitogen-activated protein kinase 8

Interaction2785
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Mitogen-activated protein kinase 14 with Magnesium
participant: Calcium release-activated calcium channel protein 1
participant: Mitogen-activated protein kinase kinase kinase 1

Interaction2786
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 14 with Magnesium activates FOS,JUN Complex
participant: FOS,JUN Complex
participant: Calcium release-activated calcium channel protein 1

Interaction2780
type: MolecularInteraction
interaction type: direct_interaction
name: RAF proto-oncogene serine/threonine-protein kinase with Phosphate activates Active Dual specificity mitogen-activated protein kinase kinase 1
participant: RAF proto-oncogene serine/threonine-protein kinase
participant: Dual specificity mitogen-activated protein kinase kinase 1

Interaction2781
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 3 with Phosphate activates FOS,JUN Complex
participant: Mitogen-activated protein kinase 3
participant: FOS,JUN Complex

Interaction2782
type: MolecularInteraction
interaction type: direct_interaction
name: Proto-oncogene vav with Phosphate activates Ras-related C3 botulinum toxin substrate 1
participant: Proto-oncogene vav
participant: Ras-related C3 botulinum toxin substrate 1

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Proto-oncogene vav
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene vav

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Calcium release-activated calcium channel protein 1
type: Protein
entity reference: Calcium release-activated calcium channel protein 1

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt P68403
organism: Rattus norvegicus

Proto-oncogene vav
type: ProteinReference
xref: Reference/UniProt P54100
organism: Rattus norvegicus

Reference/UniProt Q5BKA7
type: UnificationXref
id: Q5BKA7
db: UniProt

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P05696
organism: Rattus norvegicus

Reference/UniProt P28818
type: UnificationXref
id: P28818
db: UniProt

Interaction2697
type: MolecularInteraction
interaction type: direct_interaction
name: protein phosphatase 3 activates Nuclear factor of activated T-cells (Rattus norvegicus) + Phosphate
participant: Nuclear factor of activated T-cells (Rattus norvegicus)_Phosphate
participant: protein phosphatase 3

Interaction2693
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Calmodulin(123)
participant: Calcium
participant: Calmodulin-3

Interaction2694
type: MolecularInteraction
interaction type: direct_interaction
name: Calmodulin(123) activates protein phosphatase 3
participant: protein phosphatase 3
participant: Calmodulin-3

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: Reference/UniProt Q63320
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inositol 1,4,5-trisphosphate

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P49185
organism: Rattus norvegicus

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Mitogen-activated protein kinase 3
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 3

Reference/UniProt P05696
type: UnificationXref
id: P05696
db: UniProt

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt Q5RJJ8
type: UnificationXref
id: Q5RJJ8
db: UniProt

protein phosphatase 3
type: Complex
cellular location: Cytoplasm
component: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
component: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/UniProt Q5M848
type: UnificationXref
id: Q5M848
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Proto-oncogene tyrosine-protein kinase LCK
type: ProteinReference
xref: Reference/UniProt B1H265
organism: Rattus norvegicus

Reference/UniProt Q4FDN1
type: UnificationXref
id: Q4FDN1
db: UniProt

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt P17325
organism: Rattus norvegicus

Tyrosine-protein kinase SYK
type: ProteinReference
xref: Reference/UniProt Q64725
organism: Rattus norvegicus

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphatidylinositol 4,5-bisphosphate

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cytoplasm
entity reference: Ras-related C3 botulinum toxin substrate 1

Reference/UniProt P11345
type: UnificationXref
id: P11345
db: UniProt

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Interaction2477
type: MolecularInteraction
interaction type: direct_interaction
name: GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate
participant: GTPase HRas

Diacylglycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Diacylglycerol

Reference/UniProt Q64725
type: UnificationXref
id: Q64725
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: Reference/UniProt P10686
organism: Rattus norvegicus

Reference/UniProt P17325
type: UnificationXref
id: P17325
db: UniProt

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

B-cell linker protein
type: ProteinReference
xref: Reference/UniProt Q4KM52
organism: Rattus norvegicus

Reference/UniProt Q6RUV5
type: UnificationXref
id: Q6RUV5
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Protein kinase C beta type
type: Protein
cellular location: Cytoplasm
entity reference: Protein kinase C beta type

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Reference/UniProt Q9JJ13
type: UnificationXref
id: Q9JJ13
db: UniProt

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: Reference/UniProt Q6LDJ7
organism: Rattus norvegicus

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Protein/19593 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P11345
organism: Rattus norvegicus

Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Proto-oncogene c-Fos
type: ProteinReference
xref: Reference/UniProt Q4FDN1
organism: Rattus norvegicus

ETS domain-containing protein Elk-1
type: ProteinReference
xref: Reference/UniProt A4GTP4
organism: Rattus norvegicus

Protein/21130 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor of activated T-cells 5
stoichiometric coefficient: 1.0

Calcium release-activated calcium channel protein 1
type: Protein
cellular location: Cytoplasm
entity reference: Calcium release-activated calcium channel protein 1

Reference/UniProt P10686
type: UnificationXref
id: P10686
db: UniProt

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

Interaction2485
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex
participant: FOS,JUN Complex
participant: Mitogen-activated protein kinase 8

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

SHC-transforming protein 1
type: ProteinReference
xref: Reference/UniProt Q5M824
organism: Rattus norvegicus

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

GRB2/SOS complex
type: Complex
cellular location: Cytoplasm
component: Growth factor receptor-bound protein 2
component: Ras-specific guanine nucleotide-releasing factor 1

GTPase HRas
type: ProteinReference
xref: Reference/UniProt Q5RJJ8
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: Protein
cellular location: Cytoplasm
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Tyrosine-protein kinase SYK
type: Protein
cellular location: Cytoplasm
entity reference: Tyrosine-protein kinase SYK

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt F1MAC3
type: UnificationXref
id: F1MAC3
db: UniProt

Reference/UniProt Q5M824
type: UnificationXref
id: Q5M824
db: UniProt

Reference/UniProt P68403
type: UnificationXref
id: P68403
db: UniProt

FOS,JUN Complex
type: Complex
cellular location: Cytoplasm
component: Transcription factor AP-1
component: Proto-oncogene c-Fos

Reaction115852
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cytoplasm/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Protein/Generic440 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: B-cell receptor
stoichiometric coefficient: 1.0

Calcium release-activated calcium channel protein 1
type: ProteinReference
xref: Reference/UniProt Q5M848

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: Protein
cellular location: Cytoplasm
entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q62925
organism: Rattus norvegicus

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Transcription factor AP-1
type: Protein
cellular location: Cytoplasm
entity reference: Transcription factor AP-1

ProteinComplex/12685 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: B-cell antigen receptor complex-associated protein
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt Q62925
type: UnificationXref
id: Q62925
db: UniProt

Nuclear factor of activated T-cells 5
type: ProteinReference
xref: Reference/UniProt D3ZGB1
organism: Rattus norvegicus

Reference/PathWhiz PW122227
type: UnificationXref
id: PW122227
db: PathWhiz

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/UniProt D3ZGB1
type: UnificationXref
id: D3ZGB1
db: UniProt

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt Q6RUV5
organism: Rattus norvegicus

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt P54100
type: UnificationXref
id: P54100
db: UniProt

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

B-cell antigen receptor complex-associated protein
type: Complex
cellular location: Cytoplasm
component: B29/Ig-beta/CD79b
component: Uncharacterized protein

Mitogen-activated protein kinase 8
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 8

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097908 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytoplasm/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP31
organism: Rattus norvegicus

Proto-oncogene c-Fos
type: Protein
cellular location: Cytoplasm
entity reference: Proto-oncogene c-Fos

Growth factor receptor-bound protein 2
type: ProteinReference
xref: Reference/UniProt Q5BKA7
organism: Rattus norvegicus

Protein kinase C complex
type: Complex
cellular location: Cytoplasm
component: Protein kinase C beta type
component: Protein kinase C alpha type

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt Q9Z1I5
organism: Rattus norvegicus

Reference/UniProt A4GTP4
type: UnificationXref
id: A4GTP4
db: UniProt

Growth factor receptor-bound protein 2
type: Protein
cellular location: Cytoplasm
entity reference: Growth factor receptor-bound protein 2

B29/Ig-beta/CD79b
type: Protein
cellular location: Cytoplasm
entity reference: B29/Ig-beta/CD79b

B-cell linker protein
type: Protein
cellular location: Cytoplasm
entity reference: B-cell linker protein

Reference/SMPDB SMP0120964
type: UnificationXref
id: SMP0120964
db: SMPDB

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Ras-specific guanine nucleotide-releasing factor 1
type: ProteinReference
xref: Reference/UniProt P28818
organism: Rattus norvegicus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: Reference/UniProt Q9JJ13
organism: Rattus norvegicus

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q5EBD5
organism: Rattus norvegicus

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt F1MAP5
type: UnificationXref
id: F1MAP5
db: UniProt

ETS domain-containing protein Elk-1
type: Protein
cellular location: Cytoplasm
entity reference: ETS domain-containing protein Elk-1

Ras-specific guanine nucleotide-releasing factor 1
type: Protein
cellular location: Cytoplasm
entity reference: Ras-specific guanine nucleotide-releasing factor 1

Reference/UniProt Q9Z1I5
type: UnificationXref
id: Q9Z1I5
db: UniProt

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0