RELA
type: Protein
cellular location: Nucleus
entity reference: RELA

Compound/PW C104585 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Compound/Generic25 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 446013
type: UnificationXref
id: 446013
db: PubChem-compound

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cytoplasm
entity reference: Monocyte differentiation antigen CD14

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/UniProt Q7TQN4
type: UnificationXref
id: Q7TQN4
db: UniProt

Reaction147997
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
right: Malonyl-CoA
spontaneous: false
left: Acetyl-CoA
name: Acetyl-CoA → Malonyl-CoA
conversion direction: LEFT_TO_RIGHT

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

Reference/PubChem-compound 31348
type: UnificationXref
id: 31348
db: PubChem-compound

TNF receptor-associated factor 6
type: ProteinReference
xref: Reference/UniProt B5DF45
organism: Rattus norvegicus

direct_interaction
type: InteractionVocabulary

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B inhibitor alpha

Protein/14922 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase complex subunit C
stoichiometric coefficient: 1.0

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q6PCT8
organism: Rattus norvegicus

LPS Receptor Complex
type: Complex
cellular location: Extracellular Space
component: MD2
component: Monocyte differentiation antigen CD14
component: Toll-like receptor 4

Protein/20009 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TNF receptor-associated factor 6
stoichiometric coefficient: 1.0

Succinate dehydrogenase complex subunit C
type: ProteinReference
xref: Reference/UniProt Q641Z9
organism: Rattus norvegicus

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Nucleus
entity reference: NF-kappa-B inhibitor alpha

LPS and Citrate Signaling and Inflammation
type: Pathway
pathway order: PathwayEnzymeReaction/2121079
pathway order: PathwayEnzymeReaction/2121078
pathway order: PathwayEnzymeReaction/2121077
pathway order: PathwayEnzymeReaction/2121087
pathway order: PathwayInteraction/2818
pathway order: PathwayEnzymeReaction/2121086
pathway order: PathwayInteraction/2819
pathway order: PathwayEnzymeReaction/2121085
pathway order: PathwayInteraction/2816
pathway order: PathwayEnzymeReaction/2121084
pathway order: PathwayInteraction/2817
pathway order: PathwayEnzymeReaction/2121083
pathway order: PathwayInteraction/2814
pathway order: PathwayEnzymeReaction/2121082
pathway order: PathwayTransport/2121088
pathway order: PathwayInteraction/2815
pathway order: PathwayEnzymeReaction/2121081
pathway order: PathwayEnzymeReaction/2121080
pathway order: PathwayInteraction/2813
pathway component: Reaction179128
pathway component: Reaction179127
pathway component: Reaction179126
pathway component: Reaction179125
pathway component: ReactionCatalysis169029
pathway component: Reaction179129
pathway component: ReactionCatalysis169028
pathway component: ReactionCatalysis169027
pathway component: Reaction147997
pathway component: Interaction2813
pathway component: Interaction2814
pathway component: Interaction2815
pathway component: Interaction2816
pathway component: ReactionCatalysis138263
pathway component: Reaction164141
pathway component: Interaction2817
pathway component: Reaction164142
pathway component: Interaction2818
pathway component: Interaction2819
pathway component: TransportCatalysis1453
pathway component: Reaction179131
pathway component: Reaction179130
pathway component: ReactionCatalysis169032
pathway component: ReactionCatalysis169031
pathway component: Transport10273
pathway component: Reaction164136
xref: Reference/PathWhiz PW122233
xref: Reference/SMPDB SMP0120970
organism: Rattus norvegicus

2-Hydroxybutanedioate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 160434
chemical formula: C4H4O5
molecular weight: 132.00697
structure: ChemicalStructure/PW C104588

Hydrogen ion
type: SmallMoleculeReference
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C041026

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Lipopolysaccharide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11970143
chemical formula: C205H366N3O117P5
molecular weight: 4897.147
structure: ChemicalStructure/PW C104587

2-Oxobutanedioate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 164550
chemical formula: C4H2O5
molecular weight: 129.99022
structure: ChemicalStructure/PW C104584

Protein/22099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: RCG22794, isoform CRA_a
stoichiometric coefficient: 1.0

Citrate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 31348
chemical formula: C6H5O7
molecular weight: 189.00352
structure: ChemicalStructure/PW C104585

TransportCatalysis1453
type: Catalysis
controller: Tricarboxylate transport protein, mitochondrial
controlled: Transport10273
control type: ACTIVATION

Acetyl Coenzyme A
type: SmallMoleculeReference
xref: Reference/PubChem-compound 444493
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C104583

NF-kappa-B essential modulator
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B essential modulator

ReactionCatalysis169032
type: Catalysis
controller: NADP-dependent malic enzyme
controlled: Reaction179130
control type: ACTIVATION

ReactionCatalysis169031
type: Catalysis
controller: Malate dehydrogenase, cytoplasmic
controlled: Reaction179129
control type: ACTIVATION

Transport10273
type: Transport
participant stoichiometry: Compound/PW C104585 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Citrate
spontaneous: false
left: Citrate
name: Citrate (→) Transport: Rattus norvegicus, Cell, Mitochondrial Inner Membrane to Rattus norvegicus, Cell, Mitochondrial Outer Membrane
conversion direction: LEFT_TO_RIGHT

Protein/14916 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/UniProt Q641Z9
type: UnificationXref
id: Q641Z9
db: UniProt

TNF receptor-associated factor 6
type: Protein
cellular location: Cytoplasm
entity reference: TNF receptor-associated factor 6

Reference/HMDB HMDB0001197
type: UnificationXref
id: HMDB0001197
db: HMDB

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reaction179128
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104584 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Cytoplasm/Stoichiometry/1.0
right: 2-Oxobutanedioate
spontaneous: false
left: Citrate
name: Citrate → 2-Oxobutanedioate
conversion direction: LEFT_TO_RIGHT

Reaction179127
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104585 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: Acetyl-CoA
spontaneous: false
left: Citrate
name: Citrate → Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

Reaction179126
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000932 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000964 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: FADH
spontaneous: false
left: FAD
name: FAD → FADH
conversion direction: LEFT_TO_RIGHT

Reaction179125
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104583 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104585 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104584 Mitochondrion/Stoichiometry/1.0
right: Citrate
spontaneous: false
left: Acetyl Coenzyme A
left: 2-Oxobutanedioate
name: 2-Oxobutanedioate + Acetyl Coenzyme A → Citrate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChEBI CHEBI 16238
type: UnificationXref
id: CHEBI:16238
db: ChEBI

Reference/UniProt Q920L2
type: UnificationXref
id: Q920L2
db: UniProt

ReactionCatalysis169029
type: Catalysis
controller: ATP-citrate synthase
controlled: Reaction179127
control type: ACTIVATION

Reaction179129
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104588 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104584 Cytoplasm/Stoichiometry/1.0
right: 2-Hydroxybutanedioate
spontaneous: false
left: 2-Oxobutanedioate
name: 2-Oxobutanedioate → 2-Hydroxybutanedioate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis169028
type: Catalysis
controller: Succinate dehydrogenase
controlled: Reaction179126
control type: ACTIVATION

ReactionCatalysis169027
type: Catalysis
controller: Citrate synthase, mitochondrial
controlled: Reaction179125
control type: ACTIVATION

Citrate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Citrate

NF-kappa-B essential modulator
type: ProteinReference
xref: Reference/UniProt Q6TMG5
organism: Rattus norvegicus

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

MD2
type: Protein
cellular location: Extracellular Space
entity reference: MD2

Tricarboxylate transport protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q498T8

Reference/ChemSpider 393487
type: UnificationXref
id: 393487
db: ChemSpider

NADP-dependent malic enzyme
type: Protein
cellular location: Cytoplasm
entity reference: NADP-dependent malic enzyme

Protein/14863 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrate synthase, mitochondrial
stoichiometric coefficient: 2.0

FADH
type: SmallMoleculeReference
xref: Reference/PubChem-compound 446013
xref: Reference/ChEBI CHEBI 17877
xref: Reference/BioCyc FADH2
xref: Reference/KEGG Compound C01352
xref: Reference/ChemSpider 393487
xref: Reference/HMDB HMDB0001197
xref: Reference/CAS 1910-41-4
chemical formula: C27H35N9O15P2
molecular weight: 787.1728
structure: ChemicalStructure/PW C000932

Reference/UniProt P13697
type: UnificationXref
id: P13697
db: UniProt

MD2
type: Protein
cellular location: Cytoplasm
entity reference: MD2

Compound/PW C104584 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxobutanedioate
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Fatty Acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Fatty Acid

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/UniProt Q6PCV2
type: UnificationXref
id: Q6PCV2
db: UniProt

Reference/UniProt Q63736
type: UnificationXref
id: Q63736
db: UniProt

MD2
type: ProteinReference
xref: Reference/UniProt Q56DL5
organism: Rattus norvegicus

ChemicalStructure/PW C104584
type: ChemicalStructure
structure format: SMILES
structure data: [O-]C(=O)CC(=O)C([O-])=O

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C104583
type: ChemicalStructure
structure format: SMILES

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Malate dehydrogenase, cytoplasmic

ChemicalStructure/PW C104585
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

Monocyte differentiation antigen CD14
type: ProteinReference
xref: Reference/UniProt Q6GT04
organism: Rattus norvegicus

Reference/UniProt Q6GT04
type: UnificationXref
id: Q6GT04
db: UniProt

ChemicalStructure/PW C104588
type: ChemicalStructure
structure format: SMILES
structure data: OC(CC([O-])=O)C([O-])=O

ChemicalStructure/PW C104587
type: ChemicalStructure
structure format: SMILES

Citrate synthase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Citrate synthase, mitochondrial

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/ChemSpider 559059
type: UnificationXref
id: 559059
db: ChemSpider

ChemicalStructure/PW C000932
type: ChemicalStructure
structure format: SMILES

Reaction179131
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: NADP
spontaneous: false
left: NADPH
name: NADPH → NADP
conversion direction: LEFT_TO_RIGHT

Reaction179130
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104588 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: 2-Hydroxybutanedioate
name: 2-Hydroxybutanedioate → Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/CAS 1910-41-4
type: UnificationXref
id: 1910-41-4
db: CAS

Reference/ChEBI CHEBI 35366
type: UnificationXref
id: CHEBI:35366
db: ChEBI

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

2-Hydroxybutanedioate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2-Hydroxybutanedioate

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

FAD
type: SmallMoleculeReference
xref: Reference/CAS 146-14-5
xref: Reference/HMDB HMDB0001248
xref: Reference/ChEBI CHEBI 16238
xref: Reference/BioCyc FAD
xref: Reference/PubChem-compound 643975
xref: Reference/ChemSpider 559059
xref: Reference/KEGG Compound C00016
chemical formula: C27H33N9O15P2
molecular weight: 785.1571
structure: ChemicalStructure/PW C000964

Reference/KEGG Compound C00016
type: UnificationXref
id: C00016
db: KEGG Compound

FAD
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: FAD

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Acetyl Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl Coenzyme A

Reference/PubChem-compound 164550
type: UnificationXref
id: 164550
db: PubChem-compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

FADH
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: FADH

Compound/PW C104585 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid

RELA
type: Protein
cellular location: Cytoplasm
entity reference: RELA

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Malonyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Malonyl-CoA

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/KEGG Compound C01352
type: UnificationXref
id: C01352
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/UniProt B5DF45
type: UnificationXref
id: B5DF45
db: UniProt

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

CHUK-IKBKB-IKBKG complex
type: Complex
component stoichiometry: Protein/20025 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/19505 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Inhibitor of nuclear factor kappa-B kinase subunit beta
component: NF-kappa-B essential modulator

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt Q8VHF5
type: UnificationXref
id: Q8VHF5
db: UniProt

RCG22794, isoform CRA_a
type: ProteinReference
xref: Reference/UniProt D3ZXA5
organism: Rattus norvegicus

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q0QEZ3
organism: Rattus norvegicus

ATP-citrate synthase
type: Protein
cellular location: Cytoplasm
entity reference: ATP-citrate synthase

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q920L2
organism: Rattus norvegicus

2-Oxobutanedioate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-Oxobutanedioate

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

NADP-dependent malic enzyme
type: Complex
component stoichiometry: Protein/16350 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: NADP-dependent malic enzyme

Hydrogen ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen ion

ChemicalStructure/PW C000964
type: ChemicalStructure
structure format: SMILES

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/UniProt Q56DL5
type: UnificationXref
id: Q56DL5
db: UniProt

Interaction2813
type: MolecularInteraction
interaction type: direct_interaction
name: Citrate inhibits 6-phosphofructokinase, muscle type
participant: ATP-dependent 6-phosphofructokinase, muscle type
participant: Citrate

Interaction2814
type: MolecularInteraction
interaction type: direct_interaction
name: Citrate inhibits Succinate dehydrogenase
participant: Succinate dehydrogenase
participant: Citrate

Interaction2815
type: MolecularInteraction
interaction type: direct_interaction
name: Lipopolysaccharide activates LPS Receptor Complex
participant: Lipopolysaccharide
participant: LPS Receptor Complex

Interaction2816
type: MolecularInteraction
interaction type: direct_interaction
name: Myeloid differentiation primary response protein MyD88 (Rattus norvegicus) + Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus) + TNF receptor-associated factor 6 (Rattus norvegicus) activates LPS Receptor Complex
participant: BoundComplex/500 Cytoplasm
participant: LPS Receptor Complex

Reference/UniProt Q9QY78
type: UnificationXref
id: Q9QY78
db: UniProt

Compound/PW C000932 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: FADH
stoichiometric coefficient: 1.0

NFKB1,NFKBIA,RELA Complex with Phosphate
type: Complex
cellular location: Cytoplasm
component: RELA
component: NF-kappa-B inhibitor alpha
component: Nuclear factor NF-kappa-B p105 subunit

Reference/UniProt B2RYS5
type: UnificationXref
id: B2RYS5
db: UniProt

Acetyl-CoA carboxylase 1
type: Protein
cellular location: Cytoplasm
entity reference: Acetyl-CoA carboxylase 1

Citrate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Citrate

ReactionCatalysis138263
type: Catalysis
controller: Acetyl-CoA carboxylase 1
controlled: Reaction147997
control type: ACTIVATION

Interaction2817
type: MolecularInteraction
interaction type: direct_interaction
name: LPS Receptor Complex activates CHUK-IKBKB-IKBKG complex
participant: CHUK-IKBKB-IKBKG complex
participant: LPS Receptor Complex

Protein/19505 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inhibitor of nuclear factor kappa-B kinase subunit beta
stoichiometric coefficient: 1.0

Interaction2818
type: MolecularInteraction
interaction type: direct_interaction
name: CHUK-IKBKB-IKBKG complex activates NFKB1,NFKBIA,RELA Complex with Phosphate
participant: CHUK-IKBKB-IKBKG complex
participant: NFKB1,NFKBIA,RELA Complex with Phosphate

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt Q9QX05
organism: Rattus norvegicus

RELA
type: ProteinReference
xref: Reference/UniProt Q7TQN4
organism: Rattus norvegicus

Interaction2819
type: MolecularInteraction
interaction type: direct_interaction
name: NFKB1,NFKBIA,RELA Complex with Phosphate activates Nuclear factor NF-kappa-B p105 subunit
participant: NFKB1,NFKBIA,RELA Complex with Phosphate
participant: Nuclear factor NF-kappa-B p105 subunit

Citrate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Citrate

Lipopolysaccharide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lipopolysaccharide

Protein/20025 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B essential modulator
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17877
type: UnificationXref
id: CHEBI:17877
db: ChEBI

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

ATP-dependent 6-phosphofructokinase, muscle type
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: ATP-dependent 6-phosphofructokinase, muscle type

Compound/PW C104588 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hydroxybutanedioate
stoichiometric coefficient: 1.0

Reaction164136
type: BiochemicalReaction
participant stoichiometry: Compound/Generic25 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
right: Fatty Acid
spontaneous: false
left: Malonyl-CoA
name: Malonyl-CoA → Fatty Acid
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q0QEZ3
type: UnificationXref
id: Q0QEZ3
db: UniProt

Protein/16350 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: NADP-dependent malic enzyme
stoichiometric coefficient: 4.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

ATP-citrate synthase
type: Complex
component stoichiometry: Protein/17330 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: ATP-citrate synthase

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Protein/17330 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: ATP-citrate synthase
stoichiometric coefficient: 4.0

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Compound/PW C104585 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 643975
type: UnificationXref
id: 643975
db: PubChem-compound

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/14911 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14916 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14922 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14926 Mitochondrial Inner Membrane/Stoichiometry/1.0
cellular location: Mitochondrial Inner Membrane
component: Succinate dehydrogenase complex subunit C
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Reference/PubChem-compound 160434
type: UnificationXref
id: 160434
db: PubChem-compound

Reference/UniProt Q6PCT8
type: UnificationXref
id: Q6PCT8
db: UniProt

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

2-Oxobutanedioate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2-Oxobutanedioate

Citrate synthase, mitochondrial
type: Complex
component stoichiometry: Protein/14863 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Citrate synthase, mitochondrial

Compound/PW C104583 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl Coenzyme A
stoichiometric coefficient: 1.0

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/HMDB HMDB0001248
type: UnificationXref
id: HMDB0001248
db: HMDB

Protein/22101 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myeloid differentiation primary response protein MyD88
stoichiometric coefficient: 1.0

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor NF-kappa-B p105 subunit

Reaction164141
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041026 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Hydrogen ion
right: NADPH
spontaneous: false
left: Pyruvic acid
name: Pyruvic acid → Hydrogen ion + NADPH
conversion direction: LEFT_TO_RIGHT

Reaction164142
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: NADP
name: NADP → Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Toll-like receptor 4
type: Protein
cellular location: Extracellular Space
entity reference: Toll-like receptor 4

Compound/PW C041026 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen ion
stoichiometric coefficient: 1.0

Reference/UniProt Q498T8
type: UnificationXref
id: Q498T8
db: UniProt

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Tricarboxylate transport protein, mitochondrial
type: Protein
entity reference: Tricarboxylate transport protein, mitochondrial

Compound/PW C000964 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/UniProt Q8VIQ1
type: UnificationXref
id: Q8VIQ1
db: UniProt

Fatty Acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 35366

Reference/UniProt Q9QX05
type: UnificationXref
id: Q9QX05
db: UniProt

Compound/PW C000911 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt P97902
type: UnificationXref
id: P97902
db: UniProt

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt Q4QRC0
organism: Rattus norvegicus

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

RCG22794, isoform CRA_a
type: Protein
cellular location: Cytoplasm
entity reference: RCG22794, isoform CRA_a

Protein/14911 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q6PCV2
organism: Rattus norvegicus

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/CAS 146-14-5
type: UnificationXref
id: 146-14-5
db: CAS

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

NFKB1,NFKBIA,RELA Complex with Phosphate
type: Complex
cellular location: Nucleus
component: RELA
component: Nuclear factor NF-kappa-B p105 subunit
component: NF-kappa-B inhibitor alpha

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/SMPDB SMP0120970
type: UnificationXref
id: SMP0120970
db: SMPDB

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

NADP-dependent malic enzyme
type: ProteinReference
xref: Reference/UniProt P13697
organism: Rattus norvegicus

Reference/PathWhiz PW122233
type: UnificationXref
id: PW122233
db: PathWhiz

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p105 subunit

LPS Receptor Complex
type: Complex
cellular location: Cytoplasm
component: MD2
component: Monocyte differentiation antigen CD14
component: Toll-like receptor 4

Compound/PW C104584 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxobutanedioate
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt Q9QY78
organism: Rattus norvegicus

Protein/14926 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Citrate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8VHF5
organism: Rattus norvegicus

Reference/UniProt D3ZXA5
type: UnificationXref
id: D3ZXA5
db: UniProt

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

ATP-citrate synthase
type: ProteinReference
xref: Reference/UniProt Q8VIQ1
organism: Rattus norvegicus

Acetyl-CoA carboxylase 1
type: ProteinReference
xref: Reference/UniProt P97902
organism: Rattus norvegicus

Reference/BioCyc FAD
type: UnificationXref
id: FAD
db: BioCyc

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: Reference/UniProt B2RYS5
organism: Rattus norvegicus

Reference/BioCyc FADH2
type: UnificationXref
id: FADH2
db: BioCyc

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt Q63369
organism: Rattus norvegicus

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

ChemicalStructure/PW C041026
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C104585 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Reference/UniProt Q63369
type: UnificationXref
id: Q63369
db: UniProt

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Succinate dehydrogenase complex subunit C
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase complex subunit C

Reference/PubChem-compound 11970143
type: UnificationXref
id: 11970143
db: PubChem-compound

ATP-dependent 6-phosphofructokinase, muscle type
type: ProteinReference
xref: Reference/UniProt Q63736
organism: Rattus norvegicus

BoundComplex/500 Cytoplasm
type: Complex
display name: Myeloid differentiation primary response protein MyD88 (Rattus norvegicus)_Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus)_TNF receptor-associated factor 6 (Rattus norvegicus)
component stoichiometry: Protein/22099 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22101 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/20009 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Myeloid differentiation primary response protein MyD88
component: RCG22794, isoform CRA_a
component: TNF receptor-associated factor 6

Monocyte differentiation antigen CD14
type: Protein
cellular location: Extracellular Space
entity reference: Monocyte differentiation antigen CD14

Reference/UniProt Q6TMG5
type: UnificationXref
id: Q6TMG5
db: UniProt

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/UniProt Q4QRC0
type: UnificationXref
id: Q4QRC0
db: UniProt

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Citrate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Citrate