Reference/UniProt Q92536
type: UnificationXref
id: Q92536
db: UniProt

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

TransportCatalysis98
type: Catalysis
controller: Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
controlled: Transport127
control type: ACTIVATION

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Reference/UniProt P08195
type: UnificationXref
id: P08195
db: UniProt

SLC3A2/4F2hc Y+L amino acid transporter 2
type: Complex
component: 4F2 cell-surface antigen heavy chain
component: Y+L amino acid transporter 2

Reference/PathWhiz PW122268
type: UnificationXref
id: PW122268
db: PathWhiz

Reference/UniProt Q07837
type: UnificationXref
id: Q07837
db: UniProt

Reference/UniProt P00915
type: UnificationXref
id: P00915
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Solute carrier family 22 member 2
type: ProteinReference
xref: Reference/UniProt O15244

Reference/ChEBI CHEBI 33709
type: UnificationXref
id: CHEBI:33709
db: ChEBI

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

L-Cysteine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Cysteine

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt Q4U2R8
type: UnificationXref
id: Q4U2R8
db: UniProt

Imino acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Imino acids

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Transport127
type: Transport
participant stoichiometry: Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
spontaneous: false
left: L-Cysteine
name: L-Cysteine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/Generic51 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Solute carrier family 22 member 6
type: Protein
entity reference: Solute carrier family 22 member 6

4F2 cell-surface antigen heavy chain
type: Protein
entity reference: 4F2 cell-surface antigen heavy chain

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

Sodium- and chloride-dependent transporter XTRP3
type: Protein
entity reference: Sodium- and chloride-dependent transporter XTRP3

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Y+L amino acid transporter 1
type: Protein
entity reference: Y+L amino acid transporter 1

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

Compound/Generic39 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

SLC3A2/4F2hc Y+L amino acid transporter 1
type: Complex
component: Y+L amino acid transporter 1
component: 4F2 cell-surface antigen heavy chain

Compound/PW C000374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
type: Complex
component: Large neutral amino acids transporter small subunit 1
component: 4F2 cell-surface antigen heavy chain

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
type: Complex
component: Large neutral amino acids transporter small subunit 2
component: 4F2 cell-surface antigen heavy chain

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Y+L amino acid transporter 2
type: Protein
entity reference: Y+L amino acid transporter 2

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Kidney Function- Proximal Convoluted Tubule
type: Pathway
pathway order: PathwayTransport/2124482
pathway order: PathwayTransport/2124491
pathway order: PathwayEnzymeReaction/2124472
pathway order: PathwayTransport/2124478
pathway order: PathwayTransport/2121552
pathway order: PathwayTransport/2124485
pathway order: PathwayTransport/2124483
pathway order: PathwayTransport/2121416
pathway order: PathwayTransport/2121415
pathway order: PathwayTransport/2121418
pathway order: PathwayTransport/2121412
pathway order: PathwayTransport/2121423
pathway order: PathwayTransport/2121554
pathway order: PathwayTransport/2121414
pathway order: PathwayTransport/2121413
pathway component: TransportCatalysis98
pathway component: TransportCatalysis1525
pathway component: Transport10366
pathway component: TransportCatalysis71
pathway component: 4.2.1.1
pathway component: Transport10362
pathway component: TransportCatalysis30
pathway component: TransportCatalysis74
pathway component: TransportCatalysis51
pathway component: TransportCatalysis73
pathway component: TransportCatalysis50
pathway component: Transport101
pathway component: TransportCatalysis1531
pathway component: TransportCatalysis68
pathway component: ReactionCatalysis1409
pathway component: Transport56
pathway component: TransportCatalysis27
pathway component: TransportCatalysis1536
pathway component: Transport55
pathway component: Transport10356
pathway component: TransportCatalysis47
pathway component: TransportCatalysis25
pathway component: Transport60
pathway component: Transport84
pathway component: Transport83
pathway component: Transport103
pathway component: Transport127
pathway component: Transport104
xref: Reference/PathWhiz PW122268
xref: Reference/SMPDB SMP0121001
organism: Homo sapiens

Excitatory amino acid transporter 3
type: Protein
entity reference: Excitatory amino acid transporter 3

Reference/ChEBI CHEBI 26271
type: UnificationXref
id: CHEBI:26271
db: ChEBI

Reference/ChEBI CHEBI 15705
type: UnificationXref
id: CHEBI:15705
db: ChEBI

Reference/UniProt Q9Y6R1
type: UnificationXref
id: Q9Y6R1
db: UniProt

Imino acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Imino acids

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

L-Amino acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15705

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Large Neutral Amino Acids

Aquaporin-1
type: ProteinReference
xref: Reference/UniProt P29972

TransportCatalysis1525
type: Catalysis
controller: Sodium/hydrogen exchanger 1
controlled: Transport10356
control type: ACTIVATION

Transport10366
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: Hydrogen carbonate
spontaneous: false
left: Sodium
left: Hydrogen carbonate
name: Hydrogen carbonate (→), Sodium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Transport10362
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Chloride ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chloride ion

Large neutral amino acids transporter small subunit 2
type: ProteinReference
xref: Reference/UniProt Q9UHI5

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 25697
type: UnificationXref
id: CHEBI:25697
db: ChEBI

Reference/ChEBI CHEBI 25696
type: UnificationXref
id: CHEBI:25696
db: ChEBI

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

TransportCatalysis1531
type: Catalysis
controller: Aquaporin-1
controlled: Transport10362
control type: ACTIVATION

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

ReactionCatalysis1409
type: Catalysis
controller: Carbonic anhydrase 1
controlled: 4.2.1.1
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Transport56
type: Transport
participant stoichiometry: Compound/Generic32 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic32 Cytosol/Stoichiometry/1.0
right: Organic Anion
spontaneous: false
left: Organic Anion
name: Organic Anion (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

TransportCatalysis1536
type: Catalysis
controller: Electrogenic sodium bicarbonate cotransporter 1
controlled: Transport10366
control type: ACTIVATION

Transport55
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10356
type: Transport
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
right: Sodium
right: Hydrogen Ion
spontaneous: false
left: Hydrogen Ion
left: Sodium
name: Sodium (→), Hydrogen Ion (←) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Compound/Generic50 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Transport60
type: Transport
participant stoichiometry: Compound/Generic39 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic39 Extracellular Space/Stoichiometry/1.0
right: Organic Cation
spontaneous: false
left: Organic Cation
name: Organic Cation (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Sodium-coupled neutral amino acid transporter 4
type: Protein
entity reference: Sodium-coupled neutral amino acid transporter 4

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Organic Anion
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Anion

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Neutral and basic amino acid transport protein rBAT
type: Protein
entity reference: Neutral and basic amino acid transport protein rBAT

B(0,+)-type amino acid transporter 1
type: Protein
entity reference: B(0,+)-type amino acid transporter 1

Sodium/hydrogen exchanger 1
type: Protein
entity reference: Sodium/hydrogen exchanger 1

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Large neutral amino acids transporter small subunit 1
type: Protein
entity reference: Large neutral amino acids transporter small subunit 1

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Sodium- and chloride-dependent transporter XTRP3
type: ProteinReference
xref: Reference/UniProt Q9NP91

4F2 cell-surface antigen heavy chain
type: ProteinReference
xref: Reference/UniProt P08195

Solute carrier family 22 member 6
type: ProteinReference
xref: Reference/UniProt Q4U2R8

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Large Neutral Amino Acids

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Y+L amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt Q9UM01

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Transport84
type: Transport
participant stoichiometry: Compound/Generic50 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic50 Extracellular Space/Stoichiometry/1.0
right: Large Neutral Amino Acids
spontaneous: false
left: Large Neutral Amino Acids
name: Large Neutral Amino Acids (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport83
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: L-Amino acid
right: Sodium
spontaneous: false
left: Sodium
left: L-Amino acid
name: L-Amino acid (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q01650
type: UnificationXref
id: Q01650
db: UniProt

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/Generic32 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Organic Anion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Anion

Reference/UniProt P19634
type: UnificationXref
id: P19634
db: UniProt

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/UniProt P29972
type: UnificationXref
id: P29972
db: UniProt

Y+L amino acid transporter 2
type: ProteinReference
xref: Reference/UniProt Q92536

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Compound/Generic39 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Excitatory amino acid transporter 3
type: ProteinReference
xref: Reference/UniProt P43005

Electrogenic sodium bicarbonate cotransporter 1
type: Protein
entity reference: Electrogenic sodium bicarbonate cotransporter 1

Reference/UniProt P43005
type: UnificationXref
id: P43005
db: UniProt

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Carbonic anhydrase 1
type: Protein
cellular location: Cytosol
entity reference: Carbonic anhydrase 1

Compound/Generic5 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
type: Complex
component: Neutral and basic amino acid transport protein rBAT
component: B(0,+)-type amino acid transporter 1

Imino acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26271

TransportCatalysis27
type: Catalysis
controller: Solute carrier family 22 member 6
controlled: Transport56
control type: ACTIVATION

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

TransportCatalysis25
type: Catalysis
controller: Aquaporin-1
controlled: Transport55
control type: ACTIVATION

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen Ion

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Compound/Generic5 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sodium-coupled neutral amino acid transporter 4
type: ProteinReference
xref: Reference/UniProt Q969I6

L-Amino acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Amino acid

4.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Hydrogen carbonate
spontaneous: false
EC number: 4.2.1.1
left: Carbon dioxide
left: Water
name: Carbon dioxide + Water → Hydrogen Ion + Hydrogen carbonate
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Large Neutral Amino Acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 33709

TransportCatalysis30
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport60
control type: ACTIVATION

Reference/UniProt Q969I6
type: UnificationXref
id: Q969I6
db: UniProt

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

B(0,+)-type amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt P82251

Solute carrier family 22 member 2
type: Protein
entity reference: Solute carrier family 22 member 2

Sodium/hydrogen exchanger 1
type: ProteinReference
xref: Reference/UniProt P19634

Neutral and basic amino acid transport protein rBAT
type: ProteinReference
xref: Reference/UniProt Q07837

Organic Cation
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25697

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/UniProt P82251
type: UnificationXref
id: P82251
db: UniProt

Large neutral amino acids transporter small subunit 1
type: ProteinReference
xref: Reference/UniProt Q01650

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

Organic Anion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25696

TransportCatalysis47
type: Catalysis
controller: Excitatory amino acid transporter 3
controlled: Transport83
control type: ACTIVATION

Compound/Generic32 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Reference/UniProt Q9UHI5
type: UnificationXref
id: Q9UHI5
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/UniProt O15244
type: UnificationXref
id: O15244
db: UniProt

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Organic Cation
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Cation

TransportCatalysis51
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
controlled: Transport84
control type: ACTIVATION

TransportCatalysis50
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
controlled: Transport84
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Hydrogen carbonate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen carbonate

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt Q9UM01
type: UnificationXref
id: Q9UM01
db: UniProt

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Sodium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Sodium

TransportCatalysis68
type: Catalysis
controller: Sodium- and chloride-dependent transporter XTRP3
controlled: Transport101
control type: ACTIVATION

Carbonic anhydrase 1
type: ProteinReference
xref: Reference/UniProt P00915
organism: Homo sapiens

Electrogenic sodium bicarbonate cotransporter 1
type: ProteinReference
xref: Reference/UniProt Q9Y6R1

Compound/Generic51 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

L-Amino acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Amino acid

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

TransportCatalysis71
type: Catalysis
controller: Sodium-coupled neutral amino acid transporter 4
controlled: Transport103
control type: ACTIVATION

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

TransportCatalysis74
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 1
controlled: Transport103
control type: ACTIVATION

TransportCatalysis73
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 2
controlled: Transport104
control type: ACTIVATION

Transport101
type: Transport
participant stoichiometry: Compound/Generic51 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic51 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Imino acids
right: Chloride ion
right: Sodium
spontaneous: false
left: Imino acids
left: Sodium
left: Chloride ion
name: Imino acids (→), Sodium (→), Chloride ion (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0121001
type: UnificationXref
id: SMP0121001
db: SMPDB

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Large neutral amino acids transporter small subunit 2
type: Protein
entity reference: Large neutral amino acids transporter small subunit 2

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Organic Cation
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Cation

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Compound/Generic50 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Aquaporin-1
type: Protein
entity reference: Aquaporin-1

Reference/UniProt Q9NP91
type: UnificationXref
id: Q9NP91
db: UniProt

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Transport103
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport104
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT