Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Kidney Function - Collecting Duct
type: Pathway
pathway order: PathwayTransport/2121629
pathway order: PathwayTransport/2121628
pathway order: PathwayTransport/2124281
pathway order: PathwayTransport/2124280
pathway order: PathwayInteraction/2827
pathway order: PathwayInteraction/2825
pathway order: PathwayEnzymeReaction/2124274
pathway order: PathwayInteraction/2823
pathway order: PathwayInteraction/2824
pathway order: PathwayTransport/2124475
pathway order: PathwayTransport/2121615
pathway order: PathwayTransport/2124459
pathway order: PathwayTransport/2121633
pathway component: TransportCatalysis187
pathway component: TransportCatalysis1510
pathway component: TransportCatalysis1532
pathway component: ReactionCatalysis1409
pathway component: TransportCatalysis23
pathway component: TransportCatalysis1507
pathway component: TransportCatalysis33
pathway component: Transport10339
pathway component: TransportCatalysis32
pathway component: Transport53
pathway component: Transport55
pathway component: Interaction2824
pathway component: Interaction2825
pathway component: 4.2.1.1
pathway component: Transport10362
pathway component: Transport62
pathway component: Interaction2827
pathway component: Transport10342
pathway component: Interaction2823
pathway component: Transport106
pathway component: Transport105
pathway component: TransportCatalysis188
xref: Reference/SMPDB SMP0121011
xref: Reference/PathWhiz PW122278
organism: Homo sapiens

direct_interaction
type: InteractionVocabulary

Reference/UniProt P00915
type: UnificationXref
id: P00915
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 57-13-6
type: UnificationXref
id: 57-13-6
db: CAS

Reference/PubChem-compound 3081372
type: UnificationXref
id: 3081372
db: PubChem-compound

Reference/HMDB HMDB0001980
type: UnificationXref
id: HMDB0001980
db: HMDB

ChemicalStructure/PW C040470
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PathWhiz PW122278
type: UnificationXref
id: PW122278
db: PathWhiz

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

V-type proton ATPase subunit B, kidney isoform
type: ProteinReference
xref: Reference/UniProt P15313

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChemSpider 1143
type: UnificationXref
id: 1143
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/BioCyc UREA
type: UnificationXref
id: UREA
db: BioCyc

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8

Reference/ChEBI CHEBI 2719
type: UnificationXref
id: CHEBI:2719
db: ChEBI

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Aquaporin-3
type: Protein
entity reference: Aquaporin-3

Sodium/potassium ATPase
type: Complex
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-3

Aldosterone
type: SmallMolecule
entity reference: Aldosterone

Urea
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Urea

Angiotensin II
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001035
xref: Reference/ChEBI CHEBI 2719
xref: Reference/PubChem-compound 172198
xref: Reference/ChemSpider 150504
xref: Reference/CAS 4474-91-3
xref: Reference/KEGG Compound C02135
chemical formula: C50H71N13O12
molecular weight: 1045.5345
structure: ChemicalStructure/PW C000816

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Band 3 anion transport protein
type: ProteinReference
xref: Reference/UniProt P02730

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Amiloride-sensitive sodium channel subunit delta
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit delta

ChemicalStructure/PW C000200
type: ChemicalStructure
structure format: SMILES
structure data: NC(N)=O

Amiloride-sensitive sodium channel subunit beta
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit beta

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Reference/UniProt P37088
type: UnificationXref
id: P37088
db: UniProt

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710

Aquaporin-2
type: Protein
entity reference: Aquaporin-2

Reference/CAS 4474-91-3
type: UnificationXref
id: 4474-91-3
db: CAS

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Transport10362
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/UniProt P02730
type: UnificationXref
id: P02730
db: UniProt

Reference/UniProt P00797
type: UnificationXref
id: P00797
db: UniProt

TransportCatalysis1532
type: Catalysis
controller: Aquaporin-2
controlled: Transport10362
control type: ACTIVATION

ChemicalStructure/PW C000816
type: ChemicalStructure
structure format: SMILES

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

ReactionCatalysis1409
type: Catalysis
controller: Carbonic anhydrase 1
controlled: 4.2.1.1
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Urea transporter 2
type: Protein
entity reference: Urea transporter 2

Urea
type: SmallMolecule
cellular location: Cytosol
entity reference: Urea

Transport53
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Transport55
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport62
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Renin
type: Protein
entity reference: Renin

Reference/PubChem-compound 53477739
type: UnificationXref
id: 53477739
db: PubChem-compound

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Reference/BioCyc D-Heptoses
type: UnificationXref
id: D-Heptoses
db: BioCyc

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Amiloride-sensitive sodium channel subunit alpha
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit alpha

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Transport10342
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Reference/CAS 9041-90-1 484-42-4
type: UnificationXref
id: 9041-90-1 484-42-4
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ChemicalStructure/PW C001326
type: ChemicalStructure
structure format: SMILES

Transport10339
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
right: Hydrogen Ion
spontaneous: false
left: Hydrogen Ion
name: Hydrogen Ion (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Epithelial Sodium Channel
type: Complex
component: Amiloride-sensitive sodium channel subunit gamma
component: Amiloride-sensitive sodium channel subunit delta
component: Amiloride-sensitive sodium channel subunit beta
component: Amiloride-sensitive sodium channel subunit alpha

Amiloride-sensitive sodium channel subunit gamma
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit gamma

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Amiloride-sensitive sodium channel subunit delta
type: ProteinReference
xref: Reference/UniProt P51172

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026

Aquaporin-3
type: ProteinReference
xref: Reference/UniProt Q92482

Reference/UniProt P41181
type: UnificationXref
id: P41181
db: UniProt

Amiloride-sensitive sodium channel subunit beta
type: ProteinReference
xref: Reference/UniProt P51168

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Angiotensin I
type: SmallMolecule
entity reference: Angiotensin I

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Carbonic anhydrase 1
type: Protein
cellular location: Cytosol
entity reference: Carbonic anhydrase 1

TransportCatalysis23
type: Catalysis
controller: Sodium/potassium ATPase
controlled: Transport53
control type: ACTIVATION

Aquaporin-2
type: ProteinReference
xref: Reference/UniProt P41181

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Compound/PW C000200 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00840
type: UnificationXref
id: C00840
db: KEGG Compound

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Reference/UniProt Q92482
type: UnificationXref
id: Q92482
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Urea
type: SmallMoleculeReference
xref: Reference/BioCyc UREA
xref: Reference/CAS 57-13-6
xref: Reference/KEGG Compound C00086
xref: Reference/HMDB HMDB0000294
xref: Reference/ChemSpider 1143
xref: Reference/PubChem-compound 1176
xref: Reference/ChEBI CHEBI 16199
chemical formula: CH4N2O
molecular weight: 60.032364
structure: ChemicalStructure/PW C000200

BiologicalState41
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Hydrogen Ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen Ion

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

TransportCatalysis187
type: Catalysis
controller: Urea transporter 2
controlled: Transport105
control type: ACTIVATION

Urea transporter 2
type: ProteinReference
xref: Reference/UniProt Q15849

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

TransportCatalysis1507
type: Catalysis
controller: V-type proton ATPase subunit B, kidney isoform
controlled: Transport10339
control type: ACTIVATION

TransportCatalysis33
type: Catalysis
controller: Epithelial Sodium Channel
controlled: Transport62
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Renin
type: ProteinReference
xref: Reference/UniProt P00797
organism: BiologicalState41

TransportCatalysis32
type: Catalysis
controller: Aquaporin-3
controlled: Transport55
control type: ACTIVATION

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023

Reference/ChEBI CHEBI 16199
type: UnificationXref
id: CHEBI:16199
db: ChEBI

4.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Hydrogen carbonate
spontaneous: false
EC number: 4.2.1.1
left: Carbon dioxide
left: Water
name: Carbon dioxide + Water → Hydrogen Ion + Hydrogen carbonate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Angiotensin I
type: SmallMoleculeReference
xref: Reference/CAS 9041-90-1 484-42-4
xref: Reference/ChemSpider 2338989
xref: Reference/HMDB HMDB0061196
xref: Reference/PubChem-compound 3081372
xref: Reference/KEGG Compound C00873
chemical formula: C62H89N17O14
molecular weight: 1295.6775
structure: ChemicalStructure/PW C040470

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Amiloride-sensitive sodium channel subunit alpha
type: ProteinReference
xref: Reference/UniProt P37088

Reference/CAS 11000-17-2
type: UnificationXref
id: 11000-17-2
db: CAS

TransportCatalysis1510
type: Catalysis
controller: Band 3 anion transport protein
controlled: Transport10342
control type: ACTIVATION

Reference/PubChem-compound 172198
type: UnificationXref
id: 172198
db: PubChem-compound

Reference/HMDB HMDB0061196
type: UnificationXref
id: HMDB0061196
db: HMDB

Band 3 anion transport protein
type: Protein
entity reference: Band 3 anion transport protein

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Interaction2824
type: MolecularInteraction
interaction type: direct_interaction
name: Angiotensin II activates Aldosterone
participant: Angiotensin II
participant: Aldosterone

Interaction2825
type: MolecularInteraction
interaction type: direct_interaction
name: Angiotensin II activates Vasopressin
participant: Angiotensin II
participant: Vasopressin

Amiloride-sensitive sodium channel subunit gamma
type: ProteinReference
xref: Reference/UniProt P51170

Reference/ChemSpider 2338989
type: UnificationXref
id: 2338989
db: ChemSpider

Interaction2827
type: MolecularInteraction
interaction type: direct_interaction
name: Renin activates Angiotensin I
participant: Renin
participant: Angiotensin I

Interaction2823
type: MolecularInteraction
interaction type: direct_interaction
name: Angiotensin I activates Angiotensin II
participant: Angiotensin II
participant: Angiotensin I

Reference/UniProt Q15849
type: UnificationXref
id: Q15849
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

TransportCatalysis188
type: Catalysis
controller: Urea transporter 2
controlled: Transport106
control type: ACTIVATION

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Angiotensin II
type: SmallMolecule
entity reference: Angiotensin II

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00873
type: UnificationXref
id: C00873
db: KEGG Compound

Reference/PubChem-compound 1176
type: UnificationXref
id: 1176
db: PubChem-compound

Reference/KEGG Compound C02135
type: UnificationXref
id: C02135
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Hydrogen carbonate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen carbonate

Reference/HMDB HMDB0000294
type: UnificationXref
id: HMDB0000294
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Carbonic anhydrase 1
type: ProteinReference
xref: Reference/UniProt P00915
organism: Homo sapiens

Vasopressin
type: SmallMoleculeReference
xref: Reference/CAS 11000-17-2
xref: Reference/PubChem-compound 53477739
xref: Reference/KEGG Compound C00840
xref: Reference/BioCyc D-Heptoses
xref: Reference/HMDB HMDB0001980
chemical formula: C46H65N13O12S2
molecular weight: 1055.4318
structure: ChemicalStructure/PW C001326

V-type proton ATPase subunit B, kidney isoform
type: Protein
entity reference: V-type proton ATPase subunit B, kidney isoform

Reference/KEGG Compound C00086
type: UnificationXref
id: C00086
db: KEGG Compound

Reference/HMDB HMDB0001035
type: UnificationXref
id: HMDB0001035
db: HMDB

Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Reference/SMPDB SMP0121011
type: UnificationXref
id: SMP0121011
db: SMPDB

Reference/ChemSpider 150504
type: UnificationXref
id: 150504
db: ChemSpider

Vasopressin
type: SmallMolecule
entity reference: Vasopressin

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Reference/UniProt P51168
type: UnificationXref
id: P51168
db: UniProt

Reference/UniProt P51172
type: UnificationXref
id: P51172
db: UniProt

Reference/UniProt P51170
type: UnificationXref
id: P51170
db: UniProt

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Reference/UniProt P15313
type: UnificationXref
id: P15313
db: UniProt

Transport106
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

Transport105
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0