Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Transient receptor potential cation channel subfamily V member 5
type: Protein
entity reference: Transient receptor potential cation channel subfamily V member 5

Kidney Function - Distal Convoluted Tubule
type: Pathway
pathway order: PathwayInteraction/2825
pathway order: PathwayInteraction/2823
pathway order: PathwayTransport/2124433
pathway order: PathwayInteraction/2824
pathway order: PathwayTransport/2124462
pathway order: PathwayTransport/2121636
pathway order: PathwayTransport/2124460
pathway order: PathwayTransport/2121657
pathway order: PathwayTransport/2124438
pathway order: PathwayTransport/2121634
pathway order: PathwayInteraction/2827
pathway order: PathwayTransport/2124436
pathway component: TransportCatalysis1522
pathway component: TransportCatalysis1532
pathway component: TransportCatalysis1524
pathway component: TransportCatalysis1523
pathway component: TransportCatalysis24
pathway component: TransportCatalysis23
pathway component: TransportCatalysis22
pathway component: TransportCatalysis32
pathway component: Transport53
pathway component: Transport10354
pathway component: Transport52
pathway component: Transport10355
pathway component: Transport55
pathway component: Transport54
pathway component: Interaction2824
pathway component: Interaction2825
pathway component: Transport10362
pathway component: Interaction2827
pathway component: Transport10353
pathway component: Interaction2823
xref: Reference/PathWhiz PW122279
xref: Reference/SMPDB SMP0121012
organism: Homo sapiens

direct_interaction
type: InteractionVocabulary

Sodium/calcium exchanger 1
type: Protein
entity reference: Sodium/calcium exchanger 1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/PubChem-compound 3081372
type: UnificationXref
id: 3081372
db: PubChem-compound

Reference/HMDB HMDB0001980
type: UnificationXref
id: HMDB0001980
db: HMDB

ChemicalStructure/PW C040470
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P20648
type: UnificationXref
id: P20648
db: UniProt

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/PathWhiz PW122279
type: UnificationXref
id: PW122279
db: PathWhiz

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt P51800
type: UnificationXref
id: P51800
db: UniProt

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8

Reference/ChEBI CHEBI 2719
type: UnificationXref
id: CHEBI:2719
db: ChEBI

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Chloride channel protein ClC-Ka
type: ProteinReference
xref: Reference/UniProt P51800

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Compound/PW C000374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Aquaporin-3
type: Protein
entity reference: Aquaporin-3

Sodium/potassium ATPase
type: Complex
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-3

Aldosterone
type: SmallMolecule
entity reference: Aldosterone

Angiotensin II
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001035
xref: Reference/ChEBI CHEBI 2719
xref: Reference/PubChem-compound 172198
xref: Reference/ChemSpider 150504
xref: Reference/CAS 4474-91-3
xref: Reference/KEGG Compound C02135
chemical formula: C50H71N13O12
molecular weight: 1045.5345
structure: ChemicalStructure/PW C000816

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Potassium-transporting ATPase subunit beta
type: ProteinReference
xref: Reference/UniProt P51164

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Solute carrier family 12 member 3
type: Protein
entity reference: Solute carrier family 12 member 3

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

TransportCatalysis1522
type: Catalysis
controller: H(+)/K(+) ATPase subunit
controlled: Transport10353
control type: ACTIVATION

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

TransportCatalysis1524
type: Catalysis
controller: Sodium/calcium exchanger 1
controlled: Transport10355
control type: ACTIVATION

TransportCatalysis1523
type: Catalysis
controller: Transient receptor potential cation channel subfamily V member 5
controlled: Transport10354
control type: ACTIVATION

Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710

Aquaporin-2
type: Protein
entity reference: Aquaporin-2

Reference/CAS 4474-91-3
type: UnificationXref
id: 4474-91-3
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Potassium-transporting ATPase alpha chain 1
type: ProteinReference
xref: Reference/UniProt P20648

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

Transport10362
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Chloride ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chloride ion

Reference/UniProt P00797
type: UnificationXref
id: P00797
db: UniProt

TransportCatalysis1532
type: Catalysis
controller: Aquaporin-2
controlled: Transport10362
control type: ACTIVATION

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

ChemicalStructure/PW C000816
type: ChemicalStructure
structure format: SMILES

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Transient receptor potential cation channel subfamily V member 5
type: ProteinReference
xref: Reference/UniProt Q9NQA5

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Sodium/calcium exchanger 1
type: ProteinReference
xref: Reference/UniProt P32418

Transport53
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10354
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport52
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
name: Chloride ion (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10355
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Calcium
right: Sodium
spontaneous: false
left: Sodium
left: Calcium
name: Calcium (→), Sodium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Transport55
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport54
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
right: Chloride ion
spontaneous: false
left: Chloride ion
name: Chloride ion (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Transport10353
type: Transport
participant stoichiometry: Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Potassium
spontaneous: false
left: Potassium
left: Hydrogen Ion
name: Hydrogen Ion (←), Potassium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Renin
type: Protein
entity reference: Renin

Reference/PubChem-compound 53477739
type: UnificationXref
id: 53477739
db: PubChem-compound

Reference/BioCyc D-Heptoses
type: UnificationXref
id: D-Heptoses
db: BioCyc

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Reference/CAS 9041-90-1 484-42-4
type: UnificationXref
id: 9041-90-1 484-42-4
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt P55017
type: UnificationXref
id: P55017
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001326
type: ChemicalStructure
structure format: SMILES

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026

Reference/UniProt P41181
type: UnificationXref
id: P41181
db: UniProt

Aquaporin-3
type: ProteinReference
xref: Reference/UniProt Q92482

Solute carrier family 12 member 3
type: ProteinReference
xref: Reference/UniProt P55017

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Angiotensin I
type: SmallMolecule
entity reference: Angiotensin I

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Reference/UniProt Q9NQA5
type: UnificationXref
id: Q9NQA5
db: UniProt

TransportCatalysis24
type: Catalysis
controller: Chloride channel protein ClC-Ka
controlled: Transport54
control type: ACTIVATION

TransportCatalysis23
type: Catalysis
controller: Sodium/potassium ATPase
controlled: Transport53
control type: ACTIVATION

TransportCatalysis22
type: Catalysis
controller: Solute carrier family 12 member 3
controlled: Transport52
control type: ACTIVATION

Aquaporin-2
type: ProteinReference
xref: Reference/UniProt P41181

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Reference/KEGG Compound C00840
type: UnificationXref
id: C00840
db: KEGG Compound

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Reference/UniProt Q92482
type: UnificationXref
id: Q92482
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

BiologicalState41
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Hydrogen Ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen Ion

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Renin
type: ProteinReference
xref: Reference/UniProt P00797
organism: BiologicalState41

TransportCatalysis32
type: Catalysis
controller: Aquaporin-3
controlled: Transport55
control type: ACTIVATION

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Angiotensin I
type: SmallMoleculeReference
xref: Reference/CAS 9041-90-1 484-42-4
xref: Reference/ChemSpider 2338989
xref: Reference/HMDB HMDB0061196
xref: Reference/PubChem-compound 3081372
xref: Reference/KEGG Compound C00873
chemical formula: C62H89N17O14
molecular weight: 1295.6775
structure: ChemicalStructure/PW C040470

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 11000-17-2
type: UnificationXref
id: 11000-17-2
db: CAS

Reference/PubChem-compound 172198
type: UnificationXref
id: 172198
db: PubChem-compound

Reference/HMDB HMDB0061196
type: UnificationXref
id: HMDB0061196
db: HMDB

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Interaction2824
type: MolecularInteraction
interaction type: direct_interaction
name: Angiotensin II activates Aldosterone
participant: Angiotensin II
participant: Aldosterone

Interaction2825
type: MolecularInteraction
interaction type: direct_interaction
name: Angiotensin II activates Vasopressin
participant: Angiotensin II
participant: Vasopressin

Reference/ChemSpider 2338989
type: UnificationXref
id: 2338989
db: ChemSpider

Interaction2827
type: MolecularInteraction
interaction type: direct_interaction
name: Renin activates Angiotensin I
participant: Renin
participant: Angiotensin I

Interaction2823
type: MolecularInteraction
interaction type: direct_interaction
name: Angiotensin I activates Angiotensin II
participant: Angiotensin II
participant: Angiotensin I

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Angiotensin II
type: SmallMolecule
entity reference: Angiotensin II

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00873
type: UnificationXref
id: C00873
db: KEGG Compound

Reference/KEGG Compound C02135
type: UnificationXref
id: C02135
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

H(+)/K(+) ATPase subunit
type: Complex
component stoichiometry: Protein/1340/Stoichiometry/1.0
component stoichiometry: Protein/1354/Stoichiometry/1.0
component: Potassium-transporting ATPase subunit beta
component: Potassium-transporting ATPase alpha chain 1

Vasopressin
type: SmallMoleculeReference
xref: Reference/CAS 11000-17-2
xref: Reference/PubChem-compound 53477739
xref: Reference/KEGG Compound C00840
xref: Reference/BioCyc D-Heptoses
xref: Reference/HMDB HMDB0001980
chemical formula: C46H65N13O12S2
molecular weight: 1055.4318
structure: ChemicalStructure/PW C001326

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/UniProt P32418
type: UnificationXref
id: P32418
db: UniProt

Reference/HMDB HMDB0001035
type: UnificationXref
id: HMDB0001035
db: HMDB

Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion

Protein/1354/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase alpha chain 1
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Reference/SMPDB SMP0121012
type: UnificationXref
id: SMP0121012
db: SMPDB

Reference/ChemSpider 150504
type: UnificationXref
id: 150504
db: ChemSpider

Chloride channel protein ClC-Ka
type: Protein
entity reference: Chloride channel protein ClC-Ka

Vasopressin
type: SmallMolecule
entity reference: Vasopressin

Potassium-transporting ATPase subunit beta
type: Protein
entity reference: Potassium-transporting ATPase subunit beta

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Reference/UniProt P51164
type: UnificationXref
id: P51164
db: UniProt

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Protein/1340/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase subunit beta
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Potassium-transporting ATPase alpha chain 1
type: Protein
entity reference: Potassium-transporting ATPase alpha chain 1

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0