1.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104669 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102453 Mitochondrion/Stoichiometry/1.0
right: Hydrogen Ion
right: Farnesoic Acid
right: NADH
spontaneous: false
EC number: 1.2.1.3
left: NAD
left: Water
left: 2-trans,6-trans-Farnesal
name: 2-trans,6-trans-Farnesal + NAD + Water → Farnesoic Acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reaction179347
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002120/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104669/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 2-trans,6-trans-Farnesal
right: Hydrogen Ion
right: NADPH
spontaneous: false
left: Farnesol
left: NADP
name: Farnesol + NADP → 2-trans,6-trans-Farnesal + Hydrogen Ion + NADPH
conversion direction: LEFT_TO_RIGHT

3.1.3.-,3.1.3.16, 3.1.3.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000768 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002120 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/2.0
right: Phosphate
right: Farnesol
spontaneous: false
EC number: 3.1.3.-,3.1.3.16, 3.1.3.41
left: Farnesyl pyrophosphate
left: Water
name: Farnesyl pyrophosphate + 2 Water → Farnesol + 2 Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

2.1.1.325
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102453/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102455/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Methyl Farnesoate
spontaneous: false
EC number: 2.1.1.325
left: Farnesoic Acid
left: S-Adenosylmethionine
name: Farnesoic Acid + S-Adenosylmethionine → Methyl Farnesoate + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc 3-OH-BENZYL-ALCOHOL
type: UnificationXref
id: 3-OH-BENZYL-ALCOHOL
db: BioCyc

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C102458 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: (10S)-Juvenile hormone III diol
stoichiometric coefficient: 1.0

Reference/CAS 22963-93-5
type: UnificationXref
id: 22963-93-5
db: CAS

Compound/PW C102455/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methyl Farnesoate
stoichiometric coefficient: 1.0

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

SubPathwayInteraction109732
type: Interaction
name: SubPathway109732Reaction
name: SubPathwayReaction
participant: Farnesyl pyrophosphate

(10S)-Juvenile hormone III diol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: (10S)-Juvenile hormone III diol

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

3.3.2.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102458 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102457 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: (10S)-Juvenile hormone III diol
spontaneous: false
EC number: 3.3.2.9
left: Water
left: Juvenile Hormone III
name: Juvenile Hormone III + Water → (10S)-Juvenile hormone III diol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C104669
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)=CCC\C(C)=C\CC\C(C)=C\C=O

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

3.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102457 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102459 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001247 Mitochondrion/Stoichiometry/1.0
right: Methanol
right: Juvenile Hormone III Acid
spontaneous: false
EC number: 3.1.1.-
left: Water
left: Juvenile Hormone III
name: Juvenile Hormone III + Water → Juvenile Hormone III Acid + Methanol
conversion direction: LEFT_TO_RIGHT

(10S)-Juvenile hormone III acid diol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: (10S)-Juvenile hormone III acid diol

Reference/SMPDB SMP0121063
type: UnificationXref
id: SMP0121063
db: SMPDB

Reference/KEGG Compound C00448
type: UnificationXref
id: C00448
db: KEGG Compound

3.3.2.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102459 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102460 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: (10S)-Juvenile hormone III acid diol
spontaneous: false
EC number: 3.3.2.9
left: Water
left: Juvenile Hormone III Acid
name: Juvenile Hormone III Acid + Water → (10S)-Juvenile hormone III acid diol
conversion direction: LEFT_TO_RIGHT

3.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102460 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102458 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001247 Mitochondrion/Stoichiometry/1.0
right: Methanol
right: (10S)-Juvenile hormone III acid diol
spontaneous: false
EC number: 3.1.1.-
left: (10S)-Juvenile hormone III diol
left: Water
name: (10S)-Juvenile hormone III diol + Water → (10S)-Juvenile hormone III acid diol + Methanol
conversion direction: LEFT_TO_RIGHT

Compound/PW C102457/Stoichiometry/1.0
type: Stoichiometry
physical entity: Juvenile Hormone III
stoichiometric coefficient: 1.0

2.1.1.325
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102457/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102459/Stoichiometry/1.0
right: Juvenile Hormone III
right: S-Adenosylhomocysteine
spontaneous: false
EC number: 2.1.1.325
left: Juvenile Hormone III Acid
left: S-Adenosylmethionine
name: Juvenile Hormone III Acid + S-Adenosylmethionine → Juvenile Hormone III + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Methanol
type: SmallMoleculeReference
xref: Reference/ChemSpider 864
xref: Reference/HMDB HMDB0001875
xref: Reference/CAS 67-56-1
xref: Reference/PubChem-compound 887
xref: Reference/BioCyc 3-OH-BENZYL-ALCOHOL
xref: Reference/ChEBI CHEBI 17790
xref: Reference/KEGG Compound C00132
chemical formula: CH4O
molecular weight: 32.026215
structure: ChemicalStructure/PW C001247

Uncharacterized protein
type: Protein
cellular location: Cytosol
entity reference: Uncharacterized protein

Compound/PW C001104 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 2.0

Reference/ChemSpider 393270
type: UnificationXref
id: 393270
db: ChemSpider

Compound/PW C102457 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Juvenile Hormone III
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001875
type: UnificationXref
id: HMDB0001875
db: HMDB

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Compound/PW C102453/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesoic Acid
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/PubChem-compound 6281
type: UnificationXref
id: 6281
db: PubChem-compound

Reaction179360
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102453/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000891/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102459/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170/Stoichiometry/1.0
right: Water
right: Juvenile Hormone III Acid
right: Flavin Mononucleotide
spontaneous: false
left: FMNH2
left: Oxygen
left: Farnesoic Acid
name: FMNH2 + Farnesoic Acid + Oxygen → Flavin Mononucleotide + Juvenile Hormone III Acid + Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

ReactionCatalysis169263
type: Catalysis
controller: Unknown
controlled: Reaction179360
control type: ACTIVATION

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/HMDB HMDB0001520
type: UnificationXref
id: HMDB0001520
db: HMDB

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/BioCyc FMN
type: UnificationXref
id: FMN
db: BioCyc

Juvenile Hormone III Acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Juvenile Hormone III Acid

Compound/PW C102459 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Juvenile Hormone III Acid
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 27493
type: UnificationXref
id: CHEBI:27493
db: ChEBI

Uncharacterized protein, isoform B
type: Protein
cellular location: Mitochondrion
entity reference: Uncharacterized protein, isoform B

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/CAS 7548-13-2
type: UnificationXref
id: 7548-13-2
db: CAS

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/PubChem-compound 445395
type: UnificationXref
id: 445395
db: PubChem-compound

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Unknown
type: Protein
entity reference: Unknown

ReactionCatalysis169257
type: Catalysis
controller: Unknown
controlled: Reaction179355
control type: ACTIVATION

NADPH
type: SmallMolecule
entity reference: NADPH

Reaction179355
type: BiochemicalReaction
participant stoichiometry: Compound/PW C102455/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C102457/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000891/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001170/Stoichiometry/1.0
right: Juvenile Hormone III
right: Water
right: Flavin Mononucleotide
spontaneous: false
left: FMNH2
left: Oxygen
left: Methyl Farnesoate
name: FMNH2 + Methyl Farnesoate + Oxygen → Flavin Mononucleotide + Juvenile Hormone III + Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 445713
type: UnificationXref
id: 445713
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ReactionCatalysis169253
type: Catalysis
controller: Juvenile hormone acid O-methyltransferase
controlled: 2.1.1.325
control type: ACTIVATION

ReactionCatalysis169252
type: Catalysis
controller: Uncharacterized protein, isoform B
controlled: 1.2.1.3
control type: ACTIVATION

ReactionCatalysis169251
type: Catalysis
controller: FI06485p
controlled: Reaction179347
control type: ACTIVATION

Compound/PW C102460 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: (10S)-Juvenile hormone III acid diol
stoichiometric coefficient: 1.0

ReactionCatalysis169250
type: Catalysis
controller: Uncharacterized protein
controlled: 3.1.3.-,3.1.3.16, 3.1.3.41
control type: ACTIVATION

Reference/UniProt A1ZA98
type: UnificationXref
id: A1ZA98
db: UniProt

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

Reference/CAS 5666-16-0
type: UnificationXref
id: 5666-16-0
db: CAS

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChemSpider 392816
type: UnificationXref
id: 392816
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

FMNH2
type: SmallMolecule
entity reference: FMNH2

Oxygen
type: SmallMolecule
entity reference: Oxygen

2-trans,6-trans-Farnesal
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15894
xref: Reference/KEGG Compound C03461
xref: Reference/PubChem-compound 6281
chemical formula: C15H24O
molecular weight: 220.18271
structure: ChemicalStructure/PW C104669

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChEBI CHEBI 15894
type: UnificationXref
id: CHEBI:15894
db: ChEBI

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Terpenoid backbone biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109732
pathway component: SubPathwayInteraction109732
name: SubPathway

Juvenile Hormone Synthesis
type: Pathway
pathway order: PathwayEnzymeReaction/2122618
pathway order: PathwayEnzymeReaction/2122570
pathway order: PathwayEnzymeReaction/2122572
pathway order: PathwayEnzymeReaction/2122673
pathway order: PathwayEnzymeReaction/2122674
pathway order: PathwayEnzymeReaction/2122675
pathway order: PathwayEnzymeReaction/2122665
pathway order: PathwayEnzymeReaction/2122676
pathway order: PathwayEnzymeReaction/2122677
pathway order: PathwayEnzymeReaction/2122568
pathway order: PathwayEnzymeReaction/2122679
pathway order: PathwaySubPathway/109732
pathway component: 1.2.1.3
pathway component: Reaction179347
pathway component: 3.3.2.9
pathway component: 3.1.3.-,3.1.3.16, 3.1.3.41
pathway component: 3.1.1.-
pathway component: 2.1.1.325
pathway component: ReactionCatalysis169257
pathway component: Reaction179360
pathway component: Terpenoid backbone biosynthesis
pathway component: Reaction179355
pathway component: ReactionCatalysis169253
pathway component: ReactionCatalysis169252
pathway component: ReactionCatalysis169263
pathway component: ReactionCatalysis169251
pathway component: ReactionCatalysis169250
pathway component: ReactionCatalysis144010
pathway component: ReactionCatalysis144013
pathway component: ReactionCatalysis144015
pathway component: ReactionCatalysis144006
pathway component: ReactionCatalysis144008
xref: Reference/SMPDB SMP0121063
xref: Reference/PathWhiz PW122332
organism: Drosophila melanogaster

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Compound/PW C001247 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methanol
stoichiometric coefficient: 1.0

Farnesyl pyrophosphate
type: SmallMolecule
entity reference: Farnesyl pyrophosphate
name: SubPathwayOutput

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChemSpider 559060
type: UnificationXref
id: 559060
db: ChemSpider

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16619
type: UnificationXref
id: CHEBI:16619
db: ChEBI

Flavin Mononucleotide
type: SmallMolecule
entity reference: Flavin Mononucleotide

Flavin Mononucleotide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001520
xref: Reference/BioCyc FMN
xref: Reference/ChemSpider 559060
xref: Reference/CAS 146-17-8
xref: Reference/ChEBI CHEBI 17621
xref: Reference/PubChem-compound 643976
xref: Reference/KEGG Compound C00061
chemical formula: C17H21N4O9P
molecular weight: 456.1046
structure: ChemicalStructure/PW C001170

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 84162
type: UnificationXref
id: CHEBI:84162
db: ChEBI

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Uncharacterized protein, isoform B
type: ProteinReference
organism: Drosophila melanogaster

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/KEGG Compound C00132
type: UnificationXref
id: C00132
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Compound/PW C102460 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (10S)-Juvenile hormone III acid diol
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt M9PJJ5
organism: Drosophila melanogaster

Juvenile Hormone III Acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Juvenile Hormone III Acid

FI06485p
type: ProteinReference
xref: Reference/UniProt Q8IRN0
organism: Drosophila melanogaster

(10S)-Juvenile hormone III diol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: (10S)-Juvenile hormone III diol

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/CAS 10485-70-8
type: UnificationXref
id: 10485-70-8
db: CAS

Reference/PubChem-compound 445070
type: UnificationXref
id: 445070
db: PubChem-compound

Reference/ChEBI CHEBI 16048
type: UnificationXref
id: CHEBI:16048
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Juvenile Hormone III
type: SmallMolecule
entity reference: Juvenile Hormone III

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMolecule
entity reference: S-Adenosylhomocysteine

Juvenile Hormone III Acid
type: SmallMolecule
entity reference: Juvenile Hormone III Acid

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

(10S)-Juvenile hormone III acid diol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 47205802
xref: Reference/KEGG Compound C16506
xref: Reference/ChEBI CHEBI 80538
chemical formula: C15H26O4
molecular weight: 270.1831
structure: ChemicalStructure/PW C102460

Reference/CAS 106-28-5
type: UnificationXref
id: 106-28-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Farnesol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004305
xref: Reference/BioCyc 2-TRANS6-TRANS-FARNESOL
xref: Reference/ChEBI CHEBI 16619
xref: Reference/CAS 106-28-5
xref: Reference/KEGG Compound C01126
xref: Reference/PubChem-compound 445070
xref: Reference/ChemSpider 392816
chemical formula: C15H26O
molecular weight: 222.19836
structure: ChemicalStructure/PW C002120

Compound/PW C002120/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesol
stoichiometric coefficient: 1.0

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Juvenile Hormone III
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Juvenile Hormone III

Farnesol
type: SmallMolecule
entity reference: Farnesol

Juvenile hormone acid O-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q9VJK8
organism: Drosophila melanogaster

Compound/PW C102459/Stoichiometry/1.0
type: Stoichiometry
physical entity: Juvenile Hormone III Acid
stoichiometric coefficient: 1.0

Epoxide hydrolase
type: ProteinReference
xref: Reference/UniProt Q7JRC3
organism: Drosophila melanogaster

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Carboxylic ester hydrolase
type: ProteinReference
xref: Reference/UniProt A1ZA98
organism: Drosophila melanogaster

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Carboxylic ester hydrolase
type: Protein
cellular location: Mitochondrion
entity reference: Carboxylic ester hydrolase

Juvenile Hormone III Acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 80536
xref: Reference/KEGG Compound C16504
xref: Reference/PubChem-compound 47205800
chemical formula: C15H24O3
molecular weight: 252.17255
structure: ChemicalStructure/PW C102459

Farnesoic Acid
type: SmallMolecule
entity reference: Farnesoic Acid

Reference/PubChem-compound 47205799
type: UnificationXref
id: 47205799
db: PubChem-compound

(10S)-Juvenile hormone III diol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 47205801
xref: Reference/KEGG Compound C16505
chemical formula: C16H28O4
molecular weight: 284.19876
structure: ChemicalStructure/PW C102458

Reference/PubChem-compound 47205798
type: UnificationXref
id: 47205798
db: PubChem-compound

Methyl Farnesoate
type: SmallMolecule
entity reference: Methyl Farnesoate

Methyl Farnesoate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 80535
xref: Reference/KEGG Compound C16503
xref: Reference/CAS 10485-70-8
xref: Reference/PubChem-compound 47205799
chemical formula: C16H26O2
molecular weight: 250.19328
structure: ChemicalStructure/PW C102455

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Juvenile Hormone III
type: SmallMoleculeReference
xref: Reference/CAS 22963-93-5
xref: Reference/KEGG Compound C09694
xref: Reference/ChEBI CHEBI 27493
xref: Reference/PubChem-compound 11884
chemical formula: C16H26O3
molecular weight: 266.1882
structure: ChemicalStructure/PW C102457

2-trans,6-trans-Farnesal
type: SmallMolecule
entity reference: 2-trans,6-trans-Farnesal

Reference/ChEBI CHEBI 17621
type: UnificationXref
id: CHEBI:17621
db: ChEBI

Reference/CAS 67-56-1
type: UnificationXref
id: 67-56-1
db: CAS

Farnesoic Acid
type: SmallMoleculeReference
xref: Reference/CAS 7548-13-2
xref: Reference/ChEBI CHEBI 84162
xref: Reference/KEGG Compound C16502
xref: Reference/PubChem-compound 47205798
chemical formula: C15H24O2
molecular weight: 236.17763
structure: ChemicalStructure/PW C102453

Reference/PubChem-compound 887
type: UnificationXref
id: 887
db: PubChem-compound

Reference/UniProt M9PJJ5
type: UnificationXref
id: M9PJJ5
db: UniProt

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/CAS 372-97-4
type: UnificationXref
id: 372-97-4
db: CAS

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01126
type: UnificationXref
id: C01126
db: KEGG Compound

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 80535
type: UnificationXref
id: CHEBI:80535
db: ChEBI

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

Reference/ChEBI CHEBI 80536
type: UnificationXref
id: CHEBI:80536
db: ChEBI

Reference/ChEBI CHEBI 80538
type: UnificationXref
id: CHEBI:80538
db: ChEBI

Compound/PW C000891/Stoichiometry/1.0
type: Stoichiometry
physical entity: FMNH2
stoichiometric coefficient: 1.0

Reference/UniProt Q9VJK8
type: UnificationXref
id: Q9VJK8
db: UniProt

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Compound/PW C102453 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesoic Acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

ChemicalStructure/PW C002120
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)=CCC\C(C)=C\CC\C(C)=C\CO

Reference/KEGG Compound C16506
type: UnificationXref
id: C16506
db: KEGG Compound

Reference/KEGG Compound C16502
type: UnificationXref
id: C16502
db: KEGG Compound

Reference/KEGG Compound C16503
type: UnificationXref
id: C16503
db: KEGG Compound

Compound/PW C001420 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/KEGG Compound C16504
type: UnificationXref
id: C16504
db: KEGG Compound

Reference/KEGG Compound C16505
type: UnificationXref
id: C16505
db: KEGG Compound

Farnesyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00448
xref: Reference/HMDB HMDB0000961
xref: Reference/ChemSpider 393270
xref: Reference/ChEBI CHEBI 17407
xref: Reference/CAS 372-97-4
xref: Reference/BioCyc FARNESYL-PP
xref: Reference/PubChem-compound 445713
chemical formula: C15H28O7P2
molecular weight: 382.13104
structure: ChemicalStructure/PW C000768

Unknown
type: ProteinReference
organism: Drosophila melanogaster

Reference/PubChem-compound 643976
type: UnificationXref
id: 643976
db: PubChem-compound

Reference/BioCyc 2-TRANS6-TRANS-FARNESOL
type: UnificationXref
id: 2-TRANS6-TRANS-FARNESOL
db: BioCyc

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ReactionCatalysis144010
type: Catalysis
controller: Juvenile hormone acid O-methyltransferase
controlled: 2.1.1.325
control type: ACTIVATION

Compound/PW C104669 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-trans,6-trans-Farnesal
stoichiometric coefficient: 1.0

2-trans,6-trans-Farnesal
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-trans,6-trans-Farnesal

ChemicalStructure/PW C001247
type: ChemicalStructure
structure format: SMILES
structure data: CO

Reference/KEGG Compound C00061
type: UnificationXref
id: C00061
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

ReactionCatalysis144013
type: Catalysis
controller: Epoxide hydrolase
controlled: 3.3.2.9
control type: ACTIVATION

ReactionCatalysis144015
type: Catalysis
controller: Carboxylic ester hydrolase
controlled: 3.1.1.-
control type: ACTIVATION

Reference/UniProt Q8IRN0
type: UnificationXref
id: Q8IRN0
db: UniProt

FMNH2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16048
xref: Reference/BioCyc FMNH2
xref: Reference/KEGG Compound C01847
xref: Reference/PubChem-compound 445395
xref: Reference/CAS 5666-16-0
xref: Reference/ChemSpider 393046
xref: Reference/HMDB HMDB0001142
chemical formula: C17H23N4O9P
molecular weight: 458.12027
structure: ChemicalStructure/PW C000891

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 146-17-8
type: UnificationXref
id: 146-17-8
db: CAS

Reference/BioCyc FARNESYL-PP
type: UnificationXref
id: FARNESYL-PP
db: BioCyc

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000961
type: UnificationXref
id: HMDB0000961
db: HMDB

Reference/KEGG Compound C03461
type: UnificationXref
id: C03461
db: KEGG Compound

Compound/PW C104669/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-trans,6-trans-Farnesal
stoichiometric coefficient: 1.0

Epoxide hydrolase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Epoxide hydrolase

Farnesoic Acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Farnesoic Acid

ReactionCatalysis144006
type: Catalysis
controller: Epoxide hydrolase
controlled: 3.3.2.9
control type: ACTIVATION

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

ReactionCatalysis144008
type: Catalysis
controller: Carboxylic ester hydrolase
controlled: 3.1.1.-
control type: ACTIVATION

Methanol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Methanol

Farnesol
type: SmallMolecule
cellular location: Cytosol
entity reference: Farnesol

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/PubChem-compound 47205802
type: UnificationXref
id: 47205802
db: PubChem-compound

Reference/PubChem-compound 47205801
type: UnificationXref
id: 47205801
db: PubChem-compound

Reference/KEGG Compound C01847
type: UnificationXref
id: C01847
db: KEGG Compound

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

ChemicalStructure/PW C000768
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000891
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/KEGG Compound C09694
type: UnificationXref
id: C09694
db: KEGG Compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001142
type: UnificationXref
id: HMDB0001142
db: HMDB

Reference/PubChem-compound 47205800
type: UnificationXref
id: 47205800
db: PubChem-compound

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C002120 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17790
type: UnificationXref
id: CHEBI:17790
db: ChEBI

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Juvenile Hormone III
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Juvenile Hormone III

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

Reference/PubChem-compound 11884
type: UnificationXref
id: 11884
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/HMDB HMDB0004305
type: UnificationXref
id: HMDB0004305
db: HMDB

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C102453
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)=CCC\C(C)=C\CC\C(C)=C\C(O)=O

(10S)-Juvenile hormone III acid diol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: (10S)-Juvenile hormone III acid diol

ChemicalStructure/PW C102455
type: ChemicalStructure
structure format: SMILES
structure data: COC(=O)\C=C(/C)CC\C=C(/C)CCC=C(C)C

ChemicalStructure/PW C102457
type: ChemicalStructure
structure format: SMILES
structure data: COC(=O)\C=C(/C)CC\C=C(/C)CC[C@H]1OC1(C)C

ChemicalStructure/PW C102458
type: ChemicalStructure
structure format: SMILES
structure data: COC(=O)\C=C(/C)CC\C=C(/C)CC[C@H](O)C(C)(C)O

ChemicalStructure/PW C102459
type: ChemicalStructure
structure format: SMILES
structure data: C\C(CC[C@H]1OC1(C)C)=C/CC\C(C)=C\C(O)=O

Reference/UniProt Q7JRC3
type: UnificationXref
id: Q7JRC3
db: UniProt

Reference/ChEBI CHEBI 17407
type: UnificationXref
id: CHEBI:17407
db: ChEBI

Compound/PW C001170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Flavin Mononucleotide
stoichiometric coefficient: 1.0

Compound/PW C102458 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (10S)-Juvenile hormone III diol
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/BioCyc FMNH2
type: UnificationXref
id: FMNH2
db: BioCyc

Compound/PW C000749/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C102460
type: ChemicalStructure
structure format: SMILES
structure data: C\C(CC[C@H](O)C(C)(C)O)=C/CC\C(C)=C\C(O)=O

Reference/ChemSpider 393046
type: UnificationXref
id: 393046
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Farnesyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Farnesyl pyrophosphate

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Compound/PW C000768 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C102459 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Juvenile Hormone III Acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/ChemSpider 864
type: UnificationXref
id: 864
db: ChemSpider

FI06485p
type: Protein
entity reference: FI06485p

Juvenile hormone acid O-methyltransferase
type: Protein
entity reference: Juvenile hormone acid O-methyltransferase

Reference/PathWhiz PW122332
type: UnificationXref
id: PW122332
db: PathWhiz

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C102457 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Juvenile Hormone III
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001170
type: ChemicalStructure
structure format: SMILES