Reference/UniProt Q9VMY9
type: UnificationXref
id: Q9VMY9
db: UniProt

Compound/PW C000779 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroneopterin triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Dihydroneopterin triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dihydroneopterin triphosphate

ReactionCatalysis153944
type: Catalysis
controller: GTP cyclohydrolase
controlled: 3.5.4.16
control type: ACTIVATION

Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27714
type: UnificationXref
id: CHEBI:27714
db: ChEBI

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Pyrimidodiazepine synthase
type: ProteinReference
xref: Reference/UniProt Q9VSL3
organism: Drosophila melanogaster

Reference/SMPDB SMP0121064
type: UnificationXref
id: SMP0121064
db: SMPDB

SubPathwayInteraction109718
type: Interaction
name: SubPathway109718Reaction
name: SubPathwayReaction
participant: Guanosine triphosphate

Aurodrosopterin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 10872313
chemical formula: C15H15N9O3
molecular weight: 369.1298
structure: ChemicalStructure/PW C104586

7,8-dihydrolumazine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 590555
chemical formula: C6H6N4O2
molecular weight: 166.04907
structure: ChemicalStructure/PW C104582

7,8-dihydropterin
type: SmallMoleculeReference
xref: Reference/ChemSpider 58752
xref: Reference/CAS 17838-80-1
xref: Reference/PubChem-compound 65260
chemical formula: C6H7N5O
molecular weight: 165.06506
structure: ChemicalStructure/PW C104580

GTP cyclohydrolase
type: Complex
component stoichiometry: Protein/17238 Cytoplasm/Stoichiometry/10.0
component stoichiometry: Protein/10981 Cytoplasm/Stoichiometry/10.0
cellular location: Cytoplasm
component: GTP cyclohydrolase 1
component: Unknown

Pyrimidodiazepine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27714
xref: Reference/KEGG Compound C02587
xref: Reference/PubChem-compound 5579
chemical formula: C9H11N5O2
molecular weight: 221.09128
structure: ChemicalStructure/PW C104581

4.2.3.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000779 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000930 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007822 Mitochondrion/Stoichiometry/1.0
right: PPPi
right: Dyspropterin
spontaneous: false
EC number: 4.2.3.12
left: Dihydroneopterin triphosphate
name: Dihydroneopterin triphosphate → Dyspropterin + PPPi
conversion direction: LEFT_TO_RIGHT

PPPi
type: SmallMolecule
cellular location: Mitochondrion
entity reference: PPPi

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/CAS 20574-65-6
type: UnificationXref
id: 20574-65-6
db: CAS

Reference/HMDB HMDB0001195
type: UnificationXref
id: HMDB0001195
db: HMDB

Dyspropterin
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dyspropterin

Drosopterin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 189089
xref: Reference/ChemSpider 164297
xref: Reference/CAS 33466-46-5
chemical formula: C15H16N10O2
molecular weight: 368.14578
structure: ChemicalStructure/PW C104578

Reference/ChemSpider 958
type: UnificationXref
id: 958
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000779 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Dihydroneopterin triphosphate
right: Formic acid
spontaneous: false
EC number: 3.5.4.16
left: Water
left: Guanosine triphosphate
name: Guanosine triphosphate + Water → Dihydroneopterin triphosphate + Formic acid + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 950
type: UnificationXref
id: 950
db: ChemSpider

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Compound/PW C000930 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dyspropterin
stoichiometric coefficient: 1.0

Reference/CAS 17838-80-1
type: UnificationXref
id: 17838-80-1
db: CAS

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine triphosphate

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate
name: SubPathwayOutput

Reference/UniProt Q9VIP5
type: UnificationXref
id: Q9VIP5
db: UniProt

Dyspropterin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 128973
xref: Reference/ChemSpider 114280
xref: Reference/CAS 89687-39-8
xref: Reference/BioCyc 6-PYRUVOYL-5678-TETRAHYDROPTERIN
xref: Reference/HMDB HMDB0001195
xref: Reference/ChEBI CHEBI 17804
xref: Reference/KEGG Compound C03684
chemical formula: C9H11N5O3
molecular weight: 237.08618
structure: ChemicalStructure/PW C000930

Reaction179351
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104582/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104586/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104581/Stoichiometry/1.0
right: Water
right: Aurodrosopterin
spontaneous: true
left: Pyrimidodiazepine
left: 7,8-dihydrolumazine
name: 7,8-dihydrolumazine + Pyrimidodiazepine → Aurodrosopterin + Water
conversion direction: LEFT_TO_RIGHT

Reaction179350
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000930 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104581 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001847 Cytoplasm/Stoichiometry/1.0
right: Pyrimidodiazepine
right: Water
right: Oxidized glutathione
spontaneous: false
left: Dyspropterin
left: Glutathione
name: Dyspropterin + 2 Glutathione → Oxidized glutathione + Pyrimidodiazepine + Water
conversion direction: LEFT_TO_RIGHT

Dyspropterin
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dyspropterin

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

ReactionCatalysis169254
type: Catalysis
controller: Pyrimidodiazepine synthase
controlled: Reaction179350
control type: ACTIVATION

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reaction179352
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000930/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104580/Stoichiometry/1.0
right: 7,8-dihydropterin
spontaneous: false
left: Dyspropterin
name: Dyspropterin → 7,8-dihydropterin
conversion direction: LEFT_TO_RIGHT

Guanine deaminase
type: Complex
component stoichiometry: Protein/16696/Stoichiometry/2.0
component: Guanine deaminase

Dihydroneopterin triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dihydroneopterin triphosphate

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

Guanine deaminase
type: ProteinReference
xref: Reference/UniProt Q9VMY9
organism: Drosophila melanogaster

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

ChemicalStructure/PW C104578
type: ChemicalStructure
structure format: SMILES

Ammonium
type: SmallMolecule
entity reference: Ammonium

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Compound/PW C104581 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrimidodiazepine
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 164297
type: UnificationXref
id: 164297
db: ChemSpider

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

ChemicalStructure/PW C104580
type: ChemicalStructure
structure format: SMILES

Pyrimidodiazepine synthase
type: Protein
cellular location: Cytoplasm
entity reference: Pyrimidodiazepine synthase

ChemicalStructure/PW C104582
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C104581
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C1=NC2=C(NCC1)N=C(N)NC2=O

PPPi
type: SmallMoleculeReference
xref: Reference/BioCyc P3I
xref: Reference/KEGG Compound C00404
xref: Reference/PubChem-compound 983
xref: Reference/ChEBI CHEBI 39949
xref: Reference/CAS 10380-08-2
xref: Reference/HMDB HMDB0012282
xref: Reference/ChemSpider 958
chemical formula: H5O10P3
molecular weight: 257.90955
structure: ChemicalStructure/PW C007822

ChemicalStructure/PW C104586
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00127
type: UnificationXref
id: C00127
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

ChemicalStructure/PW C000930
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(=O)C1CNC2=C(N1)C(=O)NC(N)=N2

Drosopterin and Aurodrosopterin Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/2122629
pathway order: PathwayEnzymeReaction/2122581
pathway order: PathwayEnzymeReaction/2122592
pathway order: PathwaySubPathway/109718
pathway order: PathwayEnzymeReaction/2122632
pathway order: PathwayEnzymeReaction/2122633
pathway order: PathwayEnzymeReaction/2122579
pathway order: PathwayEnzymeReaction/2122590
pathway component: ReactionCatalysis153944
pathway component: 3.5.4.16
pathway component: Guanosine ribonucleotides de novo biosynthesis
pathway component: ReactionCatalysis154499
pathway component: Reaction164016
pathway component: Reaction179351
pathway component: Reaction179350
pathway component: 4.2.3.12
pathway component: ReactionCatalysis138945
pathway component: Reaction164131
pathway component: ReactionCatalysis169254
pathway component: Reaction179352
xref: Reference/SMPDB SMP0121064
xref: Reference/PathWhiz PW122333
organism: Drosophila melanogaster

Reference/PubChem-compound 65260
type: UnificationXref
id: 65260
db: PubChem-compound

Reference/UniProt Q9Y0C8
type: UnificationXref
id: Q9Y0C8
db: UniProt

Oxidized glutathione
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003337
xref: Reference/PubChem-compound 5255796
xref: Reference/ChemSpider 950
xref: Reference/KEGG Compound C00127
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/CAS 27025-41-8
xref: Reference/ChEBI CHEBI 17858
chemical formula: C20H32N6O12S2
molecular weight: 612.152
structure: ChemicalStructure/PW C001847

Protein/17238 Cytoplasm/Stoichiometry/10.0
type: Stoichiometry
physical entity: GTP cyclohydrolase 1
stoichiometric coefficient: 10.0

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Reference/ChemSpider 108735
type: UnificationXref
id: 108735
db: ChemSpider

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/CAS 33466-46-5
type: UnificationXref
id: 33466-46-5
db: CAS

Reference/CAS 89687-39-8
type: UnificationXref
id: 89687-39-8
db: CAS

Reference/ChEBI CHEBI 39949
type: UnificationXref
id: CHEBI:39949
db: ChEBI

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C104586/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aurodrosopterin
stoichiometric coefficient: 1.0

Compound/PW C001847 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized glutathione
stoichiometric coefficient: 1.0

Reference/ChemSpider 114280
type: UnificationXref
id: 114280
db: ChemSpider

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

6-pyruvoyl tetrahydrobiopterin synthase
type: Protein
cellular location: Mitochondrion
entity reference: 6-pyruvoyl tetrahydrobiopterin synthase

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Compound/PW C000779 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroneopterin triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C000930 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dyspropterin
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17804
type: UnificationXref
id: CHEBI:17804
db: ChEBI

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

GTP cyclohydrolase 1
type: Protein
cellular location: Cytoplasm
entity reference: GTP cyclohydrolase 1

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Compound/PW C104582/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydrolumazine
stoichiometric coefficient: 1.0

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Compound/PW C007822 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: PPPi
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5579
type: UnificationXref
id: 5579
db: PubChem-compound

ReactionCatalysis138945
type: Catalysis
controller: 6-pyruvoyl tetrahydrobiopterin synthase
controlled: 4.2.3.12
control type: ACTIVATION

Protein/16696/Stoichiometry/2.0
type: Stoichiometry
physical entity: Guanine deaminase
stoichiometric coefficient: 2.0

Water
type: SmallMolecule
entity reference: Water

Reference/PubChem-compound 5255796
type: UnificationXref
id: 5255796
db: PubChem-compound

Reference/CAS 10380-08-2
type: UnificationXref
id: 10380-08-2
db: CAS

GTP cyclohydrolase 1
type: ProteinReference
xref: Reference/UniProt Q9Y0C8
organism: Drosophila melanogaster

Reference/ChemSpider 58752
type: UnificationXref
id: 58752
db: ChemSpider

Reference/KEGG Compound C02587
type: UnificationXref
id: C02587
db: KEGG Compound

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Reaction164016
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104578/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104581/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104580/Stoichiometry/1.0
right: Water
right: Drosopterin
spontaneous: true
left: Pyrimidodiazepine
left: 7,8-dihydropterin
name: 7,8-dihydropterin + Pyrimidodiazepine → Drosopterin + Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 189089
type: UnificationXref
id: 189089
db: PubChem-compound

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

6-pyruvoyl tetrahydrobiopterin synthase
type: ProteinReference
xref: Reference/UniProt Q9VIP5
organism: Drosophila melanogaster

Reaction164131
type: BiochemicalReaction
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104582/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104580/Stoichiometry/1.0
right: Ammonium
right: 7,8-dihydrolumazine
spontaneous: false
left: Water
left: Hydrogen Ion
left: 7,8-dihydropterin
name: 7,8-dihydropterin + Hydrogen Ion + Water → 7,8-dihydrolumazine + Ammonium
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Unknown
type: ProteinReference
organism: Drosophila melanogaster

Reference/BioCyc 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
type: UnificationXref
id: 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
db: BioCyc

Reference/ChEBI CHEBI 18372
type: UnificationXref
id: CHEBI:18372
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C03684
type: UnificationXref
id: C03684
db: KEGG Compound

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Guanine deaminase
type: Protein
entity reference: Guanine deaminase

Reference/PubChem-compound 590555
type: UnificationXref
id: 590555
db: PubChem-compound

Reference/KEGG Compound C04895
type: UnificationXref
id: C04895
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Compound/PW C104580/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydropterin
stoichiometric coefficient: 1.0

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Dihydroneopterin triphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000980
xref: Reference/CAS 20574-65-6
xref: Reference/PubChem-compound 121885
xref: Reference/ChemSpider 108735
xref: Reference/BioCyc 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
xref: Reference/ChEBI CHEBI 18372
xref: Reference/KEGG Compound C04895
chemical formula: C9H16N5O13P3
molecular weight: 494.99576
structure: ChemicalStructure/PW C000779

Guanosine ribonucleotides de novo biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109718
pathway component: SubPathwayInteraction109718
name: SubPathway

Reference/ChEBI CHEBI 17858
type: UnificationXref
id: CHEBI:17858
db: ChEBI

Reference/PubChem-compound 10872313
type: UnificationXref
id: 10872313
db: PubChem-compound

Reference/UniProt Q9VSL3
type: UnificationXref
id: Q9VSL3
db: UniProt

Reference/PubChem-compound 121885
type: UnificationXref
id: 121885
db: PubChem-compound

Oxidized glutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxidized glutathione

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Dyspropterin
type: SmallMolecule
entity reference: Dyspropterin

Compound/PW C000930/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dyspropterin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Pyrimidodiazepine
type: SmallMolecule
entity reference: Pyrimidodiazepine

7,8-dihydrolumazine
type: SmallMolecule
entity reference: 7,8-dihydrolumazine

Reference/BioCyc 6-PYRUVOYL-5678-TETRAHYDROPTERIN
type: UnificationXref
id: 6-PYRUVOYL-5678-TETRAHYDROPTERIN
db: BioCyc

7,8-dihydropterin
type: SmallMolecule
entity reference: 7,8-dihydropterin

Aurodrosopterin
type: SmallMolecule
entity reference: Aurodrosopterin

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Glutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glutathione

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/PubChem-compound 128973
type: UnificationXref
id: 128973
db: PubChem-compound

Reference/KEGG Compound C00404
type: UnificationXref
id: C00404
db: KEGG Compound

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/HMDB HMDB0012282
type: UnificationXref
id: HMDB0012282
db: HMDB

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

ChemicalStructure/PW C000779
type: ChemicalStructure
structure format: SMILES

Pyrimidodiazepine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrimidodiazepine

Compound/PW C022608/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000980
type: UnificationXref
id: HMDB0000980
db: HMDB

Reference/HMDB HMDB0003337
type: UnificationXref
id: HMDB0003337
db: HMDB

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000080 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 2.0

Drosopterin
type: SmallMolecule
entity reference: Drosopterin

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 983
type: UnificationXref
id: 983
db: PubChem-compound

Reference/CAS 27025-41-8
type: UnificationXref
id: 27025-41-8
db: CAS

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

ChemicalStructure/PW C007822
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(=O)OP(O)(O)=O

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ReactionCatalysis154499
type: Catalysis
controller: Guanine deaminase
controlled: Reaction164131
control type: ACTIVATION

Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Compound/PW C104581/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrimidodiazepine
stoichiometric coefficient: 1.0

Protein/10981 Cytoplasm/Stoichiometry/10.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 10.0

ChemicalStructure/PW C001847
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc P3I
type: UnificationXref
id: P3I
db: BioCyc

Reference/PathWhiz PW122333
type: UnificationXref
id: PW122333
db: PathWhiz

Formic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Formic acid

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

Compound/PW C104578/Stoichiometry/1.0
type: Stoichiometry
physical entity: Drosopterin
stoichiometric coefficient: 1.0