Compound/PW C002063/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylylselenate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/KEGG Compound C01528
type: UnificationXref
id: C01528
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/SMPDB SMP0121071
type: UnificationXref
id: SMP0121071
db: SMPDB

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Thioredoxin reductase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9VNT5
organism: Drosophila melanogaster

Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Uncharacterized protein, isoform E
type: ProteinReference
organism: Drosophila melanogaster

Methionyl-tRNA synthetase
type: ProteinReference
xref: Reference/UniProt A1ZBE9
organism: Drosophila melanogaster

Hydrogen selenide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen selenide

Reference/ChemSpider 57
type: UnificationXref
id: 57
db: ChemSpider

PAPS synthetase, isoform E
type: ProteinReference
xref: Reference/UniProt Q7KUT8
organism: Drosophila melanogaster

Thioredoxin reductase 2, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Thioredoxin reductase 2, mitochondrial

Eip55E, isoform A
type: ProteinReference
xref: Reference/UniProt Q7JXZ2
organism: Drosophila melanogaster

Compound/PW C044571 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylselenic acid
stoichiometric coefficient: 1.0

Selenide, water dikinase
type: ProteinReference
xref: Reference/UniProt Q9V700
organism: Drosophila melanogaster

Compound/PW C002064/Stoichiometry/1.0
type: Stoichiometry
physical entity: Se-Methylselenocysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Compound/PW C001420/Stoichiometry/3.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 3.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Compound/PW C002727 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenocystathionine
stoichiometric coefficient: 1.0

Compound/PW C002066/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenohomocysteine
stoichiometric coefficient: 1.0

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 9100
type: UnificationXref
id: CHEBI:9100
db: ChEBI

Compound/PW C006761 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenite
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 950
type: UnificationXref
id: 950
db: ChemSpider

Reference/HMDB HMDB0004119
type: UnificationXref
id: HMDB0004119
db: HMDB

Pyrophosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Pyrophosphate

Reference/HMDB HMDB0060488
type: UnificationXref
id: HMDB0060488
db: HMDB

Reference/HMDB HMDB0004113
type: UnificationXref
id: HMDB0004113
db: HMDB

Reference/HMDB HMDB0004112
type: UnificationXref
id: HMDB0004112
db: HMDB

methylselenol
type: SmallMolecule
entity reference: methylselenol

Reference/HMDB HMDB0060489
type: UnificationXref
id: HMDB0060489
db: HMDB

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/KEGG Compound C00109
type: UnificationXref
id: C00109
db: KEGG Compound

Reaction126900
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006752/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043847/Stoichiometry/1.0
right: Hydrogen selenide
spontaneous: true
left: glutathioselenol
name: glutathioselenol → Hydrogen selenide
conversion direction: LEFT_TO_RIGHT

Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

ChemicalStructure/PW C098438
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]CC(=O)C(O)=O

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002066
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC[SeH])C(O)=O

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

ChemicalStructure/PW C002063
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002064
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]C[C@H](N)C(O)=O

Selenite
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Selenite

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reaction179389
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000080/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001847/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041604/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043847/Stoichiometry/1.0
right: Oxidized glutathione
right: glutathioselenol
spontaneous: true
left: Selenodiglutathione
left: Glutathione
name: Glutathione + Selenodiglutathione → Oxidized glutathione + glutathioselenol
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Reaction179388
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006761/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000080/Stoichiometry/4.0
participant stoichiometry: Compound/PW C001847/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041604/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Water
right: Oxidized glutathione
right: Selenodiglutathione
spontaneous: true
left: Hydrogen Ion
left: Selenite
left: Glutathione
name: 4 Glutathione + 2 Hydrogen Ion + Selenite → Oxidized glutathione + Selenodiglutathione + 3 Water
conversion direction: LEFT_TO_RIGHT

1.8.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006752 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/3.0
participant stoichiometry: Compound/PW C006761 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/5.0
right: Water
right: Hydrogen selenide
right: NADP
spontaneous: false
EC number: 1.8.1.9
left: NADPH
left: Hydrogen Ion
left: Selenite
name: 5 Hydrogen Ion + 3 NADPH + Selenite → Hydrogen selenide + 3 NADP + Water
conversion direction: LEFT_TO_RIGHT

Reaction179386
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006761/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040445/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41/Stoichiometry/1.0
right: Selenic acid
right: Reduced acceptor
spontaneous: false
left: Acceptor
left: Water
left: Selenite
name: Acceptor + Selenite + Water ← Reduced acceptor + Selenic acid
conversion direction: RIGHT_TO_LEFT

2.7.1.25,2.7.7.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002063 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040445 Nucleus/Stoichiometry/1.0
right: Pyrophosphate
right: Adenylylselenate
spontaneous: false
EC number: 2.7.1.25,2.7.7.4
left: Selenic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Selenic acid → Adenylylselenate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reaction179391
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/Generic441/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/Generic527/Stoichiometry/1.0
right: Adenosine diphosphate
right: O-Phosphoseryl-tRNA(Sec)
spontaneous: false
left: L-Seryl-tRNA(Sec)
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Seryl-tRNA(Sec) → Adenosine diphosphate + O-Phosphoseryl-tRNA(Sec)
conversion direction: LEFT_TO_RIGHT

2.9.-.-,2.9.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/Generic526/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001977/Stoichiometry/1.0
participant stoichiometry: Compound/Generic527/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: L-Selenocysteinyl-tRNA(Sec)
right: Phosphate
spontaneous: false
EC number: 2.9.-.-,2.9.1.-
left: O-Phosphoseryl-tRNA(Sec)
left: Phosphoroselenoic acid
name: O-Phosphoseryl-tRNA(Sec) + Phosphoroselenoic acid → L-Selenocysteinyl-tRNA(Sec) + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/KEGG Compound C00127
type: UnificationXref
id: C00127
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Phosphoroselenoic acid
type: SmallMolecule
entity reference: Phosphoroselenoic acid

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Protein/14808/Stoichiometry/4.0
type: Stoichiometry
physical entity: Eip55E, isoform A
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyruvic acid

Oxidized glutathione
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003337
xref: Reference/PubChem-compound 5255796
xref: Reference/ChemSpider 950
xref: Reference/KEGG Compound C00127
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/CAS 27025-41-8
xref: Reference/ChEBI CHEBI 17858
chemical formula: C20H32N6O12S2
molecular weight: 612.152
structure: ChemicalStructure/PW C001847

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/BioCyc 2-OXOBUTANOATE
type: UnificationXref
id: 2-OXOBUTANOATE
db: BioCyc

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Compound/PW C002066 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenohomocysteine
stoichiometric coefficient: 1.0

Reference/ChemSpider 389628
type: UnificationXref
id: 389628
db: ChemSpider

Reference/UniProt Q9VWF7
type: UnificationXref
id: Q9VWF7
db: UniProt

ChemicalStructure/PW C040445
type: ChemicalStructure
structure format: SMILES
structure data: O[Se](O)(=O)=O

Reference/ChemSpider 1061
type: UnificationXref
id: 1061
db: ChemSpider

Oxidized glutathione
type: SmallMolecule
entity reference: Oxidized glutathione

Reference/ChEBI CHEBI 18212
type: UnificationXref
id: CHEBI:18212
db: ChEBI

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C001195 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxo-4-methylthiobutanoic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 64685
type: UnificationXref
id: CHEBI:64685
db: ChEBI

Reference/ChemSpider 1059
type: UnificationXref
id: 1059
db: ChemSpider

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 1058
type: UnificationXref
id: 1058
db: ChemSpider

ChemicalStructure/PW C043847
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 389632
type: UnificationXref
id: 389632
db: ChemSpider

Compound/PW C000003/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Ketobutyric acid
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-1302
type: UnificationXref
id: CPD-1302
db: BioCyc

Reaction179395
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C044570 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044571 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/2.0
right: Water
right: methylselenol
right: NADP
spontaneous: false
left: NADPH
left: Methylselenic acid
left: Hydrogen Ion
name: Methylselenic acid + 2 Hydrogen Ion + 2 NADPH → NADP + Water + methylselenol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 129633
type: UnificationXref
id: 129633
db: ChemSpider

Compound/PW C006752/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen selenide
stoichiometric coefficient: 1.0

2.5.1.48,4.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000003/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Ammonia
right: 2-Ketobutyric acid
right: methylselenol
spontaneous: false
EC number: 2.5.1.48,4.4.1.1
left: Water
left: Selenomethionine
name: Selenomethionine + Water → 2-Ketobutyric acid + Ammonia + methylselenol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

6.1.1.10
type: BiochemicalReaction
participant stoichiometry: Compound/Generic29/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/Generic10/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019/Stoichiometry/1.0
right: Selenomethionyl-tRNA(Met)
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.10
left: tRNA(Met)
left: Adenosine triphosphate
left: Selenomethionine
name: tRNA(Met) + Adenosine triphosphate + Selenomethionine → Adenosine monophosphate + Pyrophosphate + Selenomethionyl-tRNA(Met)
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reaction179392
type: BiochemicalReaction
participant stoichiometry: Compound/Generic526/Stoichiometry/1.0
participant stoichiometry: DNA/Generic442/Stoichiometry/1.0
right: Protein
spontaneous: false
left: L-Selenocysteinyl-tRNA(Sec)
name: L-Selenocysteinyl-tRNA(Sec) → Protein
conversion direction: LEFT_TO_RIGHT

Reaction179399
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002727 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002066 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: Selenohomocysteine
right: Pyruvic acid
spontaneous: false
left: Water
left: Selenocystathionine
name: Selenocystathionine + Water → Ammonia + Pyruvic acid + Selenohomocysteine
conversion direction: LEFT_TO_RIGHT

Reaction179398
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002066/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007732/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002019/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007828/Stoichiometry/1.0
right: Tetrahydropteroyltri-L-glutamate
right: Selenomethionine
spontaneous: false
left: 5-Methyltetrahydropteroyltri-L-glutamate
left: Selenohomocysteine
name: 5-Methyltetrahydropteroyltri-L-glutamate + Selenohomocysteine → Selenomethionine + Tetrahydropteroyltri-L-glutamate
conversion direction: LEFT_TO_RIGHT

Reaction179397
type: BiochemicalReaction
participant stoichiometry: Compound/PW C098438 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002064 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001195 Mitochondrion/Stoichiometry/1.0
right: Methylselenopyruvate
right: L-Methionine
spontaneous: false
left: Se-Methylselenocysteine
left: 2-Oxo-4-methylthiobutanoic acid
name: 2-Oxo-4-methylthiobutanoic acid + Se-Methylselenocysteine → L-Methionine + Methylselenopyruvate
conversion direction: LEFT_TO_RIGHT

4.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044570 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002064 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: methylselenol
right: Pyruvic acid
spontaneous: false
EC number: 4.4.1.1
left: Water
left: Se-Methylselenocysteine
name: Se-Methylselenocysteine + Water → Ammonia + Pyruvic acid + methylselenol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Compound/Generic41/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/UniProt Q9VGH3
type: UnificationXref
id: Q9VGH3
db: UniProt

Reference/HMDB HMDB0006343
type: UnificationXref
id: HMDB0006343
db: HMDB

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Compound/PW C000080/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Selenocystathionine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26630
xref: Reference/ChemSpider 88693
xref: Reference/PubChem-compound 98223
xref: Reference/KEGG Compound C05699
xref: Reference/HMDB HMDB0006343
xref: Reference/CAS 2196-58-9
chemical formula: C7H14N2O4Se
molecular weight: 270.01187
structure: ChemicalStructure/PW C002727

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Compound/PW C000414 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 77012
type: UnificationXref
id: CHEBI:77012
db: ChEBI

Compound/Generic40/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29173
type: UnificationXref
id: CHEBI:29173
db: ChEBI

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt Q9VNT5
type: UnificationXref
id: Q9VNT5
db: UniProt

SD05444p2
type: ProteinReference
xref: Reference/UniProt Q9VWF7
organism: Drosophila melanogaster

Reference/PubChem-compound 108069
type: UnificationXref
id: 108069
db: PubChem-compound

Compound/PW C002019/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenomethionine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C041604
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C006752 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen selenide
stoichiometric coefficient: 1.0

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 14375
type: UnificationXref
id: 14375
db: ChemSpider

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Adenylylselenate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenylylselenate

Reference/BioCyc CPD-479
type: UnificationXref
id: CPD-479
db: BioCyc

Unknown
type: ProteinReference
organism: Drosophila melanogaster

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Phosphoroselenoic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 29269
xref: Reference/HMDB HMDB0003840
xref: Reference/KEGG Compound C05172
xref: Reference/PubChem-compound 1092
xref: Reference/ChemSpider 1061
xref: Reference/CAS 25758-66-1
chemical formula: H3O3PSe
molecular weight: 161.8985
structure: ChemicalStructure/PW C001977

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C16638
type: UnificationXref
id: C16638
db: KEGG Compound

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/CAS 26046-90-2
type: UnificationXref
id: 26046-90-2
db: CAS

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Reference/PubChem-compound 533
type: UnificationXref
id: 533
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

PAPS synthetase, isoform E
type: Protein
cellular location: Nucleus
entity reference: PAPS synthetase, isoform E

Compound/PW C002064 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Se-Methylselenocysteine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/ChEBI CHEBI 29269
type: UnificationXref
id: CHEBI:29269
db: ChEBI

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Compound/PW C044570/Stoichiometry/1.0
type: Stoichiometry
physical entity: methylselenol
stoichiometric coefficient: 1.0

Selenic acid
type: SmallMolecule
cellular location: Nucleus
entity reference: Selenic acid

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C007732/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methyltetrahydropteroyltri-L-glutamate
stoichiometric coefficient: 1.0

Compound/PW C002063 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylylselenate
stoichiometric coefficient: 1.0

2.7.9.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001977/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006752/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441/Stoichiometry/1.0
right: Phosphoric acid
right: Adenosine monophosphate
right: Phosphoroselenoic acid
spontaneous: false
EC number: 2.7.9.3
left: Water
left: Hydrogen selenide
left: Adenosine triphosphate
name: Adenosine triphosphate + Hydrogen selenide + Water ↔ Adenosine monophosphate + Phosphoric acid + Phosphoroselenoic acid
conversion direction: REVERSIBLE

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Phosphate
type: SmallMolecule
entity reference: Phosphate

2-Oxo-4-methylthiobutanoic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2-Oxo-4-methylthiobutanoic acid

Reference/CAS 25758-66-1
type: UnificationXref
id: 25758-66-1
db: CAS

Reference/UniProt Q7KUT8
type: UnificationXref
id: Q7KUT8
db: UniProt

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C006752
type: ChemicalStructure
structure format: SMILES
structure data: [SeH2]

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/CAS 583-92-6
type: UnificationXref
id: 583-92-6
db: CAS

Compound/PW C000143 Mitochondrion/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 3.0

methylselenol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64685
xref: Reference/HMDB HMDB0060488
chemical formula: CH4Se
molecular weight: 95.94782
structure: ChemicalStructure/PW C044570

Methylselenic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 77012
xref: Reference/PubChem-compound 124489574
xref: Reference/HMDB HMDB0060489
chemical formula: CH4O2Se
molecular weight: 127.93765
structure: ChemicalStructure/PW C044571

Reference/PathWhiz PW122340
type: UnificationXref
id: PW122340
db: PathWhiz

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

2-Ketobutyric acid
type: SmallMolecule
entity reference: 2-Ketobutyric acid

NADP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADP

Reference/HMDB HMDB0003337
type: UnificationXref
id: HMDB0003337
db: HMDB

Reference/KEGG Compound C01180
type: UnificationXref
id: C01180
db: KEGG Compound

ChemicalStructure/PW C007732
type: ChemicalStructure
structure format: SMILES

2-Ketobutyric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30831
xref: Reference/HMDB HMDB0000005
xref: Reference/CAS 600-18-0
xref: Reference/ChemSpider 57
xref: Reference/KEGG Compound C00109
xref: Reference/PubChem-compound 58
xref: Reference/BioCyc 2-OXOBUTANOATE
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000003

FI04487p
type: Protein
cellular location: Mitochondrion
entity reference: FI04487p

Compound/PW C000548 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

L-Seryl-tRNA(Sec)
type: SmallMoleculeReference

ChemicalStructure/PW C006761
type: ChemicalStructure
structure format: SMILES
structure data: [O-][Se]([O-])=O

ChemicalStructure/PW C001195
type: ChemicalStructure
structure format: SMILES
structure data: CSCCC(=O)C(O)=O

Protein
type: DnaReference
organism: Drosophila melanogaster

Reference/HMDB HMDB0060694
type: UnificationXref
id: HMDB0060694
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reaction127126
type: BiochemicalReaction
participant stoichiometry: Compound/Generic10/Stoichiometry/1.0
participant stoichiometry: DNA/Generic442/Stoichiometry/1.0
right: Protein
spontaneous: false
left: Selenomethionyl-tRNA(Met)
name: Selenomethionyl-tRNA(Met) → Protein
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Selenomethionyl-tRNA(Met)
type: SmallMolecule
entity reference: Selenomethionyl-tRNA(Met)

Reference/ChEBI CHEBI 33574
type: UnificationXref
id: CHEBI:33574
db: ChEBI

Compound/PW C000080/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 4.0

Reference/ChemSpider 518
type: UnificationXref
id: 518
db: ChemSpider

Cystathionine gamma-lyase
type: Complex
component stoichiometry: Protein/14808/Stoichiometry/4.0
component: Eip55E, isoform A

Reference/HMDB HMDB0012177
type: UnificationXref
id: HMDB0012177
db: HMDB

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Phosphoric acid
type: SmallMolecule
entity reference: Phosphoric acid

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChEBI CHEBI 18170
type: UnificationXref
id: CHEBI:18170
db: ChEBI

Reference/HMDB HMDB0012290
type: UnificationXref
id: HMDB0012290
db: HMDB

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Compound/PW C040445/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenic acid
stoichiometric coefficient: 1.0

NADPH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADPH

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ChemicalStructure/PW C007828
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002019
type: ChemicalStructure
structure format: SMILES
structure data: C[Se]CCC(N)C(O)=O

tRNA(Met)
type: SmallMolecule
entity reference: tRNA(Met)

Adenosine triphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenosine triphosphate

Reference/KEGG Compound C05684
type: UnificationXref
id: C05684
db: KEGG Compound

Reference/PubChem-compound 98223
type: UnificationXref
id: 98223
db: PubChem-compound

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

L-Methionine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Methionine

Reference/KEGG Compound C05689
type: UnificationXref
id: C05689
db: KEGG Compound

Compound/PW C001847/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized glutathione
stoichiometric coefficient: 1.0

ReactionCatalysis169289
type: Catalysis
controller: Uncharacterized protein, isoform E
controlled: 2.9.-.-,2.9.1.-
control type: ACTIVATION

Reference/KEGG Compound C05686
type: UnificationXref
id: C05686
db: KEGG Compound

ReactionCatalysis169288
type: Catalysis
controller: Thioredoxin reductase 2, mitochondrial
controlled: 1.8.1.9
control type: ACTIVATION

ReactionCatalysis169287
type: Catalysis
controller: Unknown
controlled: Reaction179386
control type: ACTIVATION

ReactionCatalysis169286
type: Catalysis
controller: PAPS synthetase, isoform E
controlled: 2.7.1.25,2.7.7.4
control type: ACTIVATION

Selenodiglutathione
type: SmallMolecule
entity reference: Selenodiglutathione

Reference/UniProt Q7JXZ2
type: UnificationXref
id: Q7JXZ2
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Compound/PW C000146 Mitochondrion/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 3.0

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/CAS 14124-67-5
type: UnificationXref
id: 14124-67-5
db: CAS

Acceptor
type: SmallMolecule
entity reference: Acceptor

L-Selenocysteinyl-tRNA(Sec)
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06482

O-Phosphoseryl-tRNA(Sec)
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16638

Reduced acceptor
type: SmallMolecule
entity reference: Reduced acceptor

Compound/Generic526/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Selenocysteinyl-tRNA(Sec)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/KEGG Compound C05697
type: UnificationXref
id: C05697
db: KEGG Compound

FI04487p
type: ProteinReference
xref: Reference/UniProt Q9VGH3
organism: Drosophila melanogaster

Reference/KEGG Compound C04489
type: UnificationXref
id: C04489
db: KEGG Compound

Reference/KEGG Compound C05699
type: UnificationXref
id: C05699
db: KEGG Compound

Reference/KEGG Compound C05335
type: UnificationXref
id: C05335
db: KEGG Compound

Reference/PubChem-compound 473
type: UnificationXref
id: 473
db: PubChem-compound

Reference/KEGG Compound C05698
type: UnificationXref
id: C05698
db: KEGG Compound

Compound/PW C098438 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylselenopyruvate
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Ammonia

Compound/PW C044570 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: methylselenol
stoichiometric coefficient: 1.0

Compound/Generic527/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphoseryl-tRNA(Sec)
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

DNA/Generic442/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein
stoichiometric coefficient: 1.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/PubChem-compound 58
type: UnificationXref
id: 58
db: PubChem-compound

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Compound/Generic29/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Met)
stoichiometric coefficient: 1.0

ReactionCatalysis138401
type: Catalysis
controller: Selenide, water dikinase
controlled: 2.7.9.3
control type: ACTIVATION

Compound/Generic441/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Seryl-tRNA(Sec)
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ChemicalStructure/PW C002727
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC[Se]CC(N)C(O)=O)C(O)=O

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/ChemSpider 88693
type: UnificationXref
id: 88693
db: ChemSpider

Reference/KEGG Compound C04144
type: UnificationXref
id: C04144
db: KEGG Compound

Ammonia
type: SmallMolecule
entity reference: Ammonia

Reference/ChEBI CHEBI 27812
type: UnificationXref
id: CHEBI:27812
db: ChEBI

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Selenohomocysteine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Selenohomocysteine

Compound/PW C001441/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

L-Selenocysteinyl-tRNA(Sec)
type: SmallMolecule
entity reference: L-Selenocysteinyl-tRNA(Sec)

O-Phosphoseryl-tRNA(Sec)
type: SmallMolecule
entity reference: O-Phosphoseryl-tRNA(Sec)

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Unknown
type: Protein
entity reference: Unknown

Selenodiglutathione
type: SmallMoleculeReference
xref: Reference/PubChem-compound 108069
chemical formula: C20H32N6O12S2Se
molecular weight: 692.0685
structure: ChemicalStructure/PW C041604

Reference/BioCyc SELENOMETHIONINE
type: UnificationXref
id: SELENOMETHIONINE
db: BioCyc

Reference/CAS 600-18-0
type: UnificationXref
id: 600-18-0
db: CAS

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Compound/PW C040445 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/HMDB HMDB0003840
type: UnificationXref
id: HMDB0003840
db: HMDB

Se-Methylselenocysteine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Se-Methylselenocysteine

Methylselenopyruvate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Methylselenopyruvate

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Hydrogen selenide
type: SmallMolecule
entity reference: Hydrogen selenide

SD05444p2
type: Protein
entity reference: SD05444p2

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0003966
type: UnificationXref
id: HMDB0003966
db: HMDB

Compound/PW C043847/Stoichiometry/1.0
type: Stoichiometry
physical entity: glutathioselenol
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0011110
type: UnificationXref
id: HMDB0011110
db: HMDB

Reference/ChEBI CHEBI 16503
type: UnificationXref
id: CHEBI:16503
db: ChEBI

Reference/PubChem-compound 16722111
type: UnificationXref
id: 16722111
db: PubChem-compound

Reference/PubChem-compound 16722112
type: UnificationXref
id: 16722112
db: PubChem-compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Tetrahydropteroyltri-L-glutamate
type: SmallMoleculeReference
xref: Reference/ChemSpider 17625690
xref: Reference/KEGG Compound C04144
xref: Reference/HMDB HMDB0012290
xref: Reference/BioCyc CPD-1302
xref: Reference/PubChem-compound 16722112
xref: Reference/ChEBI CHEBI 17420
chemical formula: C29H37N9O12
molecular weight: 703.25616
structure: ChemicalStructure/PW C007828

Selenomethionine
type: SmallMoleculeReference
xref: Reference/BioCyc SELENOMETHIONINE
xref: Reference/ChemSpider 14375
xref: Reference/HMDB HMDB0003966
xref: Reference/PubChem-compound 15103
xref: Reference/CAS 1464-42-2
xref: Reference/KEGG Compound C05335
xref: Reference/ChEBI CHEBI 27585
chemical formula: C5H11NO2Se
molecular weight: 196.9955
structure: ChemicalStructure/PW C002019

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001553
type: UnificationXref
id: HMDB0001553
db: HMDB

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

methylselenol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: methylselenol

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Glutathione
type: SmallMolecule
entity reference: Glutathione

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Tetrahydropteroyltri-L-glutamate
type: SmallMolecule
entity reference: Tetrahydropteroyltri-L-glutamate

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Compound/PW C007828/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydropteroyltri-L-glutamate
stoichiometric coefficient: 1.0

Selenomethionine
type: SmallMolecule
entity reference: Selenomethionine

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/PubChem-compound 440763
type: UnificationXref
id: 440763
db: PubChem-compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Reference/KEGG Compound C06482
type: UnificationXref
id: C06482
db: KEGG Compound

Methylselenic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Methylselenic acid

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0011119
type: UnificationXref
id: HMDB0011119
db: HMDB

L-Seryl-tRNA(Sec)
type: SmallMolecule
entity reference: L-Seryl-tRNA(Sec)

Reference/PubChem-compound 440758
type: UnificationXref
id: 440758
db: PubChem-compound

Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/ChEBI CHEBI 26630
type: UnificationXref
id: CHEBI:26630
db: ChEBI

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 2485
type: UnificationXref
id: CHEBI:2485
db: ChEBI

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/HMDB HMDB0000005
type: UnificationXref
id: HMDB0000005
db: HMDB

ChemicalStructure/PW C000003
type: ChemicalStructure
structure format: SMILES
structure data: CCC(=O)C(O)=O

Reference/ChemSpider 460
type: UnificationXref
id: 460
db: ChemSpider

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Selenic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 1058
xref: Reference/HMDB HMDB0060694
xref: Reference/CAS 7783-08-6
xref: Reference/ChEBI CHEBI 18170
xref: Reference/KEGG Compound C05697
xref: Reference/PubChem-compound 1089
chemical formula: H2O4Se
molecular weight: 145.91183
structure: ChemicalStructure/PW C040445

Reference/PubChem-compound 1090
type: UnificationXref
id: 1090
db: PubChem-compound

Reference/PubChem-compound 1092
type: UnificationXref
id: 1092
db: PubChem-compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChEBI CHEBI 30831
type: UnificationXref
id: CHEBI:30831
db: ChEBI

Reference/PubChem-compound 5255796
type: UnificationXref
id: 5255796
db: PubChem-compound

Reference/KEGG Compound C05172
type: UnificationXref
id: C05172
db: KEGG Compound

Reference/ChEBI CHEBI 64729
type: UnificationXref
id: CHEBI:64729
db: ChEBI

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/CAS 7783-08-6
type: UnificationXref
id: 7783-08-6
db: CAS

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Compound/PW C001977/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoroselenoic acid
stoichiometric coefficient: 1.0

Reaction126889
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002063/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006761/Stoichiometry/1.0
right: Selenite
spontaneous: false
left: Adenylylselenate
name: Adenylylselenate → Selenite
conversion direction: LEFT_TO_RIGHT

glutathioselenol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64729
chemical formula: C9H9O4
molecular weight: 181.05063
structure: ChemicalStructure/PW C043847

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Methylselenopyruvate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 124489576
chemical formula: C4H6O3Se
molecular weight: 181.94821
structure: ChemicalStructure/PW C098438

Reference/PubChem-compound 1089
type: UnificationXref
id: 1089
db: PubChem-compound

Se-Methylselenocysteine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27812
xref: Reference/ChemSpider 129633
xref: Reference/KEGG Compound C05689
xref: Reference/CAS 26046-90-2
xref: Reference/HMDB HMDB0004113
xref: Reference/PubChem-compound 147004
chemical formula: C4H9NO2Se
molecular weight: 182.97984
structure: ChemicalStructure/PW C002064

Selenohomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440763
xref: Reference/ChemSpider 389632
xref: Reference/HMDB HMDB0004119
xref: Reference/CAS 29412-93-9
xref: Reference/BioCyc SELENOHOMOCYSTEINE
xref: Reference/KEGG Compound C05698
chemical formula: C4H9NO2Se
molecular weight: 182.97984
structure: ChemicalStructure/PW C002066

Adenylylselenate
type: SmallMolecule
entity reference: Adenylylselenate

Se-Methylselenocysteine
type: SmallMolecule
entity reference: Se-Methylselenocysteine

Compound/PW C000170 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Selenohomocysteine
type: SmallMolecule
entity reference: Selenohomocysteine

Adenylylselenate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 2485
xref: Reference/ChemSpider 389628
xref: Reference/PubChem-compound 440758
xref: Reference/KEGG Compound C05686
xref: Reference/HMDB HMDB0004112
chemical formula: C10H14N5O10PSe
molecular weight: 474.96436
structure: ChemicalStructure/PW C002063

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Selenocompound Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2122780
pathway order: PathwayEnzymeReaction/2122770
pathway order: PathwayEnzymeReaction/2122760
pathway order: PathwayEnzymeReaction/2122772
pathway order: PathwayEnzymeReaction/2122762
pathway order: PathwayEnzymeReaction/2122784
pathway order: PathwayEnzymeReaction/2122774
pathway order: PathwayEnzymeReaction/2122785
pathway order: PathwayEnzymeReaction/2122786
pathway order: PathwayEnzymeReaction/2122776
pathway order: PathwayEnzymeReaction/2122787
pathway order: PathwayEnzymeReaction/2122766
pathway order: PathwayEnzymeReaction/2122777
pathway order: PathwayEnzymeReaction/2122767
pathway order: PathwayEnzymeReaction/2122778
pathway order: PathwayEnzymeReaction/2122789
pathway order: PathwayEnzymeReaction/2122768
pathway order: PathwayEnzymeReaction/2122779
pathway order: PathwayEnzymeReaction/2122758
pathway order: PathwayEnzymeReaction/2122769
pathway component: ReactionCatalysis138401
pathway component: Reaction179389
pathway component: Reaction127126
pathway component: 2.7.9.3
pathway component: ReactionCatalysis169289
pathway component: ReactionCatalysis169288
pathway component: Reaction179388
pathway component: ReactionCatalysis169287
pathway component: 1.8.1.9
pathway component: ReactionCatalysis169286
pathway component: Reaction179386
pathway component: 2.7.1.25,2.7.7.4
pathway component: Reaction179391
pathway component: 2.9.-.-,2.9.1.-
pathway component: Reaction126889
pathway component: Reaction126900
pathway component: Reaction179395
pathway component: 2.5.1.48,4.4.1.1
pathway component: 6.1.1.10
pathway component: Reaction179392
pathway component: Reaction179399
pathway component: Reaction179398
pathway component: ReactionCatalysis169298
pathway component: Reaction179397
pathway component: ReactionCatalysis169297
pathway component: 4.4.1.1
pathway component: ReactionCatalysis169296
pathway component: ReactionCatalysis169295
pathway component: ReactionCatalysis169294
pathway component: ReactionCatalysis169293
pathway component: ReactionCatalysis169292
pathway component: ReactionCatalysis169291
pathway component: ReactionCatalysis169290
xref: Reference/PathWhiz PW122340
xref: Reference/SMPDB SMP0121071
organism: Drosophila melanogaster

Compound/Generic10/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenomethionyl-tRNA(Met)
stoichiometric coefficient: 1.0

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Hydrogen selenide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0011110
xref: Reference/PubChem-compound 533
xref: Reference/CAS 7783-07-5
xref: Reference/ChEBI CHEBI 16503
xref: Reference/KEGG Compound C01528
xref: Reference/ChemSpider 518
chemical formula: H2Se
molecular weight: 81.932175
structure: ChemicalStructure/PW C006752

Reference/ChemSpider 17625690
type: UnificationXref
id: 17625690
db: ChemSpider

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/PubChem-compound 124489574
type: UnificationXref
id: 124489574
db: PubChem-compound

Reference/PubChem-compound 124489576
type: UnificationXref
id: 124489576
db: PubChem-compound

ChemicalStructure/PW C044570
type: ChemicalStructure
structure format: SMILES
structure data: C[SeH]

Selenocystathionine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Selenocystathionine

Reference/CAS 1464-42-2
type: UnificationXref
id: 1464-42-2
db: CAS

ChemicalStructure/PW C044571
type: ChemicalStructure
structure format: SMILES
structure data: C[Se](O)=O

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Reference/CAS 7783-07-5
type: UnificationXref
id: 7783-07-5
db: CAS

Reference/ChEBI CHEBI 17858
type: UnificationXref
id: CHEBI:17858
db: ChEBI

Reference/ChEBI CHEBI 17614
type: UnificationXref
id: CHEBI:17614
db: ChEBI

Reference/BioCyc SELENOHOMOCYSTEINE
type: UnificationXref
id: SELENOHOMOCYSTEINE
db: BioCyc

Reference/PubChem-compound 15103
type: UnificationXref
id: 15103
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

2-Oxo-4-methylthiobutanoic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001553
xref: Reference/KEGG Compound C01180
xref: Reference/BioCyc CPD-479
xref: Reference/CAS 583-92-6
xref: Reference/ChEBI CHEBI 33574
xref: Reference/ChemSpider 460
xref: Reference/PubChem-compound 473
chemical formula: C5H8O3S
molecular weight: 148.01941
structure: ChemicalStructure/PW C001195

5-Methyltetrahydropteroyltri-L-glutamate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 16722111
xref: Reference/BioCyc CPD-1302
xref: Reference/ChEBI CHEBI 17614
xref: Reference/ChemSpider 17625689
xref: Reference/KEGG Compound C04489
xref: Reference/HMDB HMDB0012177
chemical formula: C30H39N9O12
molecular weight: 717.2718
structure: ChemicalStructure/PW C007732

Selenite
type: SmallMoleculeReference
xref: Reference/ChemSpider 1059
xref: Reference/KEGG Compound C05684
xref: Reference/PubChem-compound 1090
xref: Reference/HMDB HMDB0011119
xref: Reference/ChEBI CHEBI 18212
xref: Reference/CAS 14124-67-5
chemical formula: O3Se
molecular weight: 127.90127
structure: ChemicalStructure/PW C006761

5-Methyltetrahydropteroyltri-L-glutamate
type: SmallMolecule
entity reference: 5-Methyltetrahydropteroyltri-L-glutamate

Selenite
type: SmallMolecule
entity reference: Selenite

Reference/ChemSpider 17625689
type: UnificationXref
id: 17625689
db: ChemSpider

tRNA(Met)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 29173

ChemicalStructure/PW C001977
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=[Se]

Reference/CAS 29412-93-9
type: UnificationXref
id: 29412-93-9
db: CAS

Reference/UniProt A1ZBE9
type: UnificationXref
id: A1ZBE9
db: UniProt

Reference/ChEBI CHEBI 17420
type: UnificationXref
id: CHEBI:17420
db: ChEBI

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 147004
type: UnificationXref
id: 147004
db: PubChem-compound

Reference/CAS 2196-58-9
type: UnificationXref
id: 2196-58-9
db: CAS

Compound/PW C006761/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenite
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Eip55E, isoform A
type: Protein
entity reference: Eip55E, isoform A

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Selenide, water dikinase
type: Protein
entity reference: Selenide, water dikinase

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Selenomethionyl-tRNA(Met)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 9100

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

Compound/PW C040034 Mitochondrion/Stoichiometry/5.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 5.0

Methionyl-tRNA synthetase
type: Protein
entity reference: Methionyl-tRNA synthetase

Uncharacterized protein, isoform E
type: Protein
entity reference: Uncharacterized protein, isoform E

Reference/ChEBI CHEBI 27585
type: UnificationXref
id: CHEBI:27585
db: ChEBI

Reference/CAS 27025-41-8
type: UnificationXref
id: 27025-41-8
db: CAS

glutathioselenol
type: SmallMolecule
entity reference: glutathioselenol

Compound/PW C041604/Stoichiometry/1.0
type: Stoichiometry
physical entity: Selenodiglutathione
stoichiometric coefficient: 1.0

Compound/PW C000146 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 2.0

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Selenic acid
type: SmallMolecule
entity reference: Selenic acid

ReactionCatalysis169298
type: Catalysis
controller: FI04487p
controlled: Reaction179399
control type: ACTIVATION

ChemicalStructure/PW C001847
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis169297
type: Catalysis
controller: Unknown
controlled: Reaction179398
control type: ACTIVATION

ReactionCatalysis169296
type: Catalysis
controller: FI04487p
controlled: Reaction179397
control type: ACTIVATION

ReactionCatalysis169295
type: Catalysis
controller: FI04487p
controlled: 4.4.1.1
control type: ACTIVATION

ReactionCatalysis169294
type: Catalysis
controller: Cystathionine gamma-lyase
controlled: 4.4.1.1
control type: ACTIVATION

ReactionCatalysis169293
type: Catalysis
controller: Thioredoxin reductase 2, mitochondrial
controlled: Reaction179395
control type: ACTIVATION

Protein
type: Dna
entity reference: Protein

ReactionCatalysis169292
type: Catalysis
controller: Cystathionine gamma-lyase
controlled: 2.5.1.48,4.4.1.1
control type: ACTIVATION

ReactionCatalysis169291
type: Catalysis
controller: Methionyl-tRNA synthetase
controlled: 6.1.1.10
control type: ACTIVATION

ReactionCatalysis169290
type: Catalysis
controller: SD05444p2
controlled: Reaction179391
control type: ACTIVATION

Reference/UniProt Q9V700
type: UnificationXref
id: Q9V700
db: UniProt