Reference/SMPDB SMP0121074
type: UnificationXref
id: SMP0121074
db: SMPDB

Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Compound/PW C001145 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc RIBOSE-1P
type: UnificationXref
id: RIBOSE-1P
db: BioCyc

Compound/PW C000154/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinamide ribotide
stoichiometric coefficient: 1.0

Nicotinic acid
type: SmallMolecule
entity reference: Nicotinic acid
name: SubPathwayOutput

Ribose 1-phosphate
type: SmallMolecule
entity reference: Ribose 1-phosphate

Reference/KEGG Compound C03150
type: UnificationXref
id: C03150
db: KEGG Compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChemSpider 13553
type: UnificationXref
id: 13553
db: ChemSpider

Nicotinamide ribotide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 14180
xref: Reference/CAS 1094-61-7
xref: Reference/HMDB HMDB0000229
xref: Reference/BioCyc NICOTINAMIDE NUCLEOTIDE
xref: Reference/ChEBI CHEBI 16171
xref: Reference/ChemSpider 13553
xref: Reference/KEGG Compound C00455
chemical formula: C11H15N2O8P
molecular weight: 334.0566
structure: ChemicalStructure/PW C000154

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Nicotinate phosphoribosyltransferase
type: Protein
cellular location: Cytosol
entity reference: Nicotinate phosphoribosyltransferase

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChemSpider 145043
type: UnificationXref
id: 145043
db: ChemSpider

NAD
type: SmallMolecule
entity reference: NAD

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Uncharacterized protein, isoform C
type: ProteinReference
xref: Reference/UniProt A8DY95
organism: Drosophila melanogaster

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Nicotinate phosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt Q9VQX4
organism: Drosophila melanogaster

Uncharacterized protein, isoform G
type: ProteinReference
xref: Reference/UniProt M9ND26
organism: Drosophila melanogaster

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Adenosine diphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenosine diphosphate

Reference/PubChem-compound 165491
type: UnificationXref
id: 165491
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

6.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000915/Stoichiometry/1.0
right: L-Glutamic acid
right: Adenosine monophosphate
right: NAD
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.1
left: Nicotinic acid adenine dinucleotide
left: Water
left: L-Glutamine
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water → Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15940
type: UnificationXref
id: CHEBI:15940
db: ChEBI

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C000143 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00455
type: UnificationXref
id: C00455
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ChemicalStructure/PW C001086
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)C1=CC=CN=C1

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Nicotinamide ribotide
type: SmallMolecule
entity reference: Nicotinamide ribotide

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Probable glutamine-dependent NAD(+) synthetase
type: Protein
entity reference: Probable glutamine-dependent NAD(+) synthetase

Reference/SMPDB SMP0087413
type: UnificationXref
id: SMP0087413
db: SMPDB

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/UniProt Q8IH17
type: UnificationXref
id: Q8IH17
db: UniProt

Reference/ChEBI CHEBI 18304
type: UnificationXref
id: CHEBI:18304
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Compound/PW C001146/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001406
type: UnificationXref
id: HMDB0001406
db: HMDB

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/PubChem-compound 161234
type: UnificationXref
id: 161234
db: PubChem-compound

ChemicalStructure/PW C000681
type: ChemicalStructure
structure format: SMILES

NAD
type: SmallMolecule
cellular location: Nucleus
entity reference: NAD

NADP
type: SmallMolecule
entity reference: NADP
name: SubPathwayInput

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

nicotinate β-D-ribonucleotide
type: SmallMolecule
entity reference: nicotinate β-D-ribonucleotide

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

Reference/PubChem-compound 938
type: UnificationXref
id: 938
db: PubChem-compound

Reference/UniProt A8DYC9
type: UnificationXref
id: A8DYC9
db: UniProt

Reference/PubChem-compound 936
type: UnificationXref
id: 936
db: PubChem-compound

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

nicotinate β-D-ribonucleotide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15763
xref: Reference/KEGG Compound C01185
xref: Reference/ChemSpider 108822
xref: Reference/HMDB HMDB0059646
xref: Reference/PubChem-compound 121992
chemical formula: C11H15NO9P
molecular weight: 336.04843
structure: ChemicalStructure/PW C040083

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Nicotinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Nicotinic acid

Reference/ChEBI CHEBI 15763
type: UnificationXref
id: CHEBI:15763
db: ChEBI

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Compound/PW C040083/Stoichiometry/1.0
type: Stoichiometry
physical entity: nicotinate β-D-ribonucleotide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0059646
type: UnificationXref
id: HMDB0059646
db: HMDB

Reference/ChEBI CHEBI 27748
type: UnificationXref
id: CHEBI:27748
db: ChEBI

Reference/ChEBI CHEBI 16171
type: UnificationXref
id: CHEBI:16171
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000681/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinamide riboside
stoichiometric coefficient: 1.0

Nicotinamide-nucleotide adenylyltransferase
type: Protein
entity reference: Nicotinamide-nucleotide adenylyltransferase

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

D-Ribose
type: SmallMoleculeReference
xref: Reference/ChemSpider 5575
xref: Reference/KEGG Compound C00121
xref: Reference/PubChem-compound 5779
xref: Reference/CAS 613-83-2
xref: Reference/BioCyc CPD-560
xref: Reference/HMDB HMDB0000283
xref: Reference/ChEBI CHEBI 47013
chemical formula: C5H10O5
molecular weight: 150.05283
structure: ChemicalStructure/PW C000191

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000915/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinic acid adenine dinucleotide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

SubPathwayInteraction110228
type: Interaction
name: SubPathway110228Reaction
name: SubPathwayReaction
participant: Nicotinic acid

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

SubPathwayInteraction110227
type: Interaction
name: SubPathway110227Reaction
name: SubPathwayReaction
participant: NADP

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00121
type: UnificationXref
id: C00121
db: KEGG Compound

Compound/PW C001034 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChEBI CHEBI 17154
type: UnificationXref
id: CHEBI:17154
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Nicotinate D-ribonucleoside
type: SmallMolecule
entity reference: Nicotinate D-ribonucleoside

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/UniProt A8DY95
type: UnificationXref
id: A8DY95
db: UniProt

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/HMDB HMDB0000229
type: UnificationXref
id: HMDB0000229
db: HMDB

Reference/KEGG Compound C00253
type: UnificationXref
id: C00253
db: KEGG Compound

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChemSpider 913
type: UnificationXref
id: 913
db: ChemSpider

Reference/ChemSpider 911
type: UnificationXref
id: 911
db: ChemSpider

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Nicotinic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15940
xref: Reference/HMDB HMDB0001488
xref: Reference/KEGG Compound C00253
xref: Reference/PubChem-compound 938
xref: Reference/CAS 59-67-6
xref: Reference/ChemSpider 913
xref: Reference/BioCyc NIACINE
chemical formula: C6H5NO2
molecular weight: 123.03203
structure: ChemicalStructure/PW C001145

Ribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 14075-00-4
xref: Reference/ChEBI CHEBI 16300
xref: Reference/HMDB HMDB0001489
xref: Reference/PubChem-compound 439236
xref: Reference/ChemSpider 388373
xref: Reference/BioCyc RIBOSE-1P
xref: Reference/KEGG Compound C00620
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001146

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChemSpider 141636
type: UnificationXref
id: 141636
db: ChemSpider

D-Ribose
type: SmallMolecule
entity reference: D-Ribose

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000190 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000915
type: ChemicalStructure
structure format: SMILES

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/BioCyc CPD-560
type: UnificationXref
id: CPD-560
db: BioCyc

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/PathWhiz PW088432
type: UnificationXref
id: PW088432
db: PathWhiz

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

nicotinate β-D-ribonucleotide
type: SmallMolecule
cellular location: Cytosol
entity reference: nicotinate β-D-ribonucleotide

Reference/PubChem-compound 14180
type: UnificationXref
id: 14180
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C001145/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinic acid
stoichiometric coefficient: 1.0

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Reference/UniProt Q8T405
type: UnificationXref
id: Q8T405
db: UniProt

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Mitochondrial Electron Transport Chain
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110227
pathway component: SubPathwayInteraction110227
xref: Reference/SMPDB SMP0087413
xref: Reference/PathWhiz PW088432
name: SubPathway

Reference/KEGG Compound C00153
type: UnificationXref
id: C00153
db: KEGG Compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis169322
type: Catalysis
controller: Nicotinate phosphoribosyltransferase
controlled: 6.3.4.21
control type: ACTIVATION

ReactionCatalysis169321
type: Catalysis
controller: Uncharacterized protein, isoform G
controlled: Reaction179420
control type: ACTIVATION

ReactionCatalysis169320
type: Catalysis
controller: Uncharacterized protein, isoform C
controlled: Reaction179419
control type: ACTIVATION

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/KEGG Compound C05841
type: UnificationXref
id: C05841
db: KEGG Compound

Niacinamide
type: SmallMoleculeReference
xref: Reference/CAS 98-92-0
xref: Reference/HMDB HMDB0001406
xref: Reference/KEGG Compound C00153
xref: Reference/PubChem-compound 936
xref: Reference/BioCyc NIACINAMIDE
xref: Reference/ChemSpider 911
xref: Reference/ChEBI CHEBI 17154
chemical formula: C6H6N2O
molecular weight: 122.04801
structure: ChemicalStructure/PW C001086

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Compound/PW C000414 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 108822
type: UnificationXref
id: 108822
db: ChemSpider

ChemicalStructure/PW C001146
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001145
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CN=CC=C1

Reference/CAS 1094-61-7
type: UnificationXref
id: 1094-61-7
db: CAS

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/ChEBI CHEBI 16300
type: UnificationXref
id: CHEBI:16300
db: ChEBI

Reference/UniProt M9ND26
type: UnificationXref
id: M9ND26
db: UniProt

Uncharacterized protein, isoform F
type: ProteinReference
xref: Reference/UniProt A8DYC9
organism: Drosophila melanogaster

ReactionCatalysis169319
type: Catalysis
controller: Nicotinamide-nucleotide adenylyltransferase
controlled: Reaction179418
control type: ACTIVATION

ReactionCatalysis169314
type: Catalysis
controller: Uncharacterized protein, isoform F
controlled: 2.7.1.23
control type: ACTIVATION

ReactionCatalysis169313
type: Catalysis
controller: Nicotinamide-nucleotide adenylyltransferase
controlled: 2.7.7.1,2.7.7.18
control type: ACTIVATION

ReactionCatalysis169312
type: Catalysis
controller: Uncharacterized protein, isoform C
controlled: 3.-.-.-
control type: ACTIVATION

ReactionCatalysis169311
type: Catalysis
controller: Uncharacterized protein, isoform G
controlled: 2.4.2.1
control type: ACTIVATION

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Compound/PW C000721 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Nicotinamide riboside
type: SmallMolecule
entity reference: Nicotinamide riboside

Reference/BioCyc NICOTINAMIDE NUCLEOTIDE
type: UnificationXref
id: NICOTINAMIDE_NUCLEOTIDE
db: BioCyc

ChemicalStructure/PW C040083
type: ChemicalStructure
structure format: SMILES

Nicotinamide-nucleotide adenylyltransferase
type: ProteinReference
xref: Reference/UniProt Q8T405
organism: Drosophila melanogaster

Nicotinamide riboside
type: SmallMoleculeReference
xref: Reference/ChemSpider 388956
xref: Reference/BioCyc NICOTINAMIDE RIBOSE
xref: Reference/HMDB HMDB0000855
xref: Reference/KEGG Compound C03150
xref: Reference/PubChem-compound 439924
xref: Reference/CAS 1341-23-7
xref: Reference/ChEBI CHEBI 15927
chemical formula: C11H15N2O5
molecular weight: 255.0981
structure: ChemicalStructure/PW C000681

Reference/CAS 14075-00-4
type: UnificationXref
id: 14075-00-4
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/KEGG Compound C00857
type: UnificationXref
id: C00857
db: KEGG Compound

Reference/PubChem-compound 121992
type: UnificationXref
id: 121992
db: PubChem-compound

Nicotinate D-ribonucleoside
type: SmallMoleculeReference
xref: Reference/ChemSpider 141636
xref: Reference/ChEBI CHEBI 27748
xref: Reference/HMDB HMDB0006809
xref: Reference/KEGG Compound C05841
xref: Reference/PubChem-compound 161234
chemical formula: C11H14NO6
molecular weight: 256.08212
structure: ChemicalStructure/PW C002943

Nicotinate and Nicotinamide Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2122818
pathway order: PathwayEnzymeReaction/2122851
pathway order: PathwayEnzymeReaction/2122852
pathway order: PathwayEnzymeReaction/2122897
pathway order: PathwayEnzymeReaction/2122898
pathway order: PathwaySubPathway/110228
pathway order: PathwaySubPathway/110227
pathway order: PathwayEnzymeReaction/2122845
pathway order: PathwayEnzymeReaction/2122900
pathway order: PathwayEnzymeReaction/2122901
pathway order: PathwayEnzymeReaction/2122902
pathway component: 2.7.1.23
pathway component: 2.7.7.1,2.7.7.18
pathway component: 6.3.5.1
pathway component: 3.-.-.-
pathway component: ReactionCatalysis169319
pathway component: ReactionCatalysis138464
pathway component: Reaction179418
pathway component: Mitochondrial Electron Transport Chain
pathway component: ReactionCatalysis169314
pathway component: Dietary sources
pathway component: ReactionCatalysis169313
pathway component: ReactionCatalysis169312
pathway component: ReactionCatalysis169311
pathway component: ReactionCatalysis169322
pathway component: 2.4.2.1
pathway component: ReactionCatalysis169321
pathway component: 6.3.4.21
pathway component: ReactionCatalysis169320
pathway component: Reaction179420
pathway component: Reaction179419
xref: Reference/SMPDB SMP0121074
xref: Reference/PathWhiz PW122343
organism: Drosophila melanogaster

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/BioCyc NIACINAMIDE
type: UnificationXref
id: NIACINAMIDE
db: BioCyc

Reference/HMDB HMDB0006809
type: UnificationXref
id: HMDB0006809
db: HMDB

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000154
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)C1=CC=C[N+](=C1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001489
type: UnificationXref
id: HMDB0001489
db: HMDB

Reference/HMDB HMDB0001488
type: UnificationXref
id: HMDB0001488
db: HMDB

Reference/BioCyc NICOTINAMIDE RIBOSE
type: UnificationXref
id: NICOTINAMIDE_RIBOSE
db: BioCyc

Niacinamide
type: SmallMolecule
entity reference: Niacinamide

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/UniProt Q9VQX4
type: UnificationXref
id: Q9VQX4
db: UniProt

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChemSpider 5575
type: UnificationXref
id: 5575
db: ChemSpider

Reference/CAS 613-83-2
type: UnificationXref
id: 613-83-2
db: CAS

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/CAS 59-67-6
type: UnificationXref
id: 59-67-6
db: CAS

Reference/KEGG Compound C00620
type: UnificationXref
id: C00620
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Probable glutamine-dependent NAD(+) synthetase
type: ProteinReference
xref: Reference/UniProt Q8IH17
organism: Drosophila melanogaster

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000283
type: UnificationXref
id: HMDB0000283
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 388956
type: UnificationXref
id: 388956
db: ChemSpider

ReactionCatalysis138464
type: Catalysis
controller: Probable glutamine-dependent NAD(+) synthetase
controlled: 6.3.5.1
control type: ACTIVATION

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/PubChem-compound 5779
type: UnificationXref
id: 5779
db: PubChem-compound

6.3.4.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001145 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Nicotinic acid
right: Adenosine triphosphate
right: Phosphoribosyl pyrophosphate
right: Hydrogen Ion
right: Water
spontaneous: false
EC number: 6.3.4.21
left: Phosphate
left: nicotinate β-D-ribonucleotide
left: Adenosine diphosphate
left: Pyrophosphate
name: Adenosine diphosphate + Phosphate + Pyrophosphate + nicotinate β-D-ribonucleotide ↔ Adenosine triphosphate + Hydrogen Ion + Nicotinic acid + Phosphoribosyl pyrophosphate + Water
conversion direction: REVERSIBLE

Phosphate
type: SmallMolecule
entity reference: Phosphate

ChemicalStructure/PW C002943
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)[N+]1=CC(=CC=C1)C(O)=O

Reaction179420
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002943/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001145/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Nicotinic acid
right: Ribose 1-phosphate
right: Hydrogen Ion
spontaneous: false
left: Phosphate
left: Nicotinate D-ribonucleoside
name: Nicotinate D-ribonucleoside + Phosphate ↔ Hydrogen Ion + Nicotinic acid + Ribose 1-phosphate
conversion direction: REVERSIBLE

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/CAS 6450-77-7
type: UnificationXref
id: 6450-77-7
db: CAS

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C040083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: nicotinate β-D-ribonucleotide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439236
type: UnificationXref
id: 439236
db: PubChem-compound

Reference/HMDB HMDB0000855
type: UnificationXref
id: HMDB0000855
db: HMDB

Reference/PathWhiz PW122343
type: UnificationXref
id: PW122343
db: PathWhiz

Uncharacterized protein, isoform C
type: Protein
entity reference: Uncharacterized protein, isoform C

Uncharacterized protein, isoform G
type: Protein
entity reference: Uncharacterized protein, isoform G

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/CAS 1341-23-7
type: UnificationXref
id: 1341-23-7
db: CAS

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

2.7.1.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Nucleus/Stoichiometry/1.0
right: NADP
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.23
left: NAD
left: Adenosine triphosphate
name: Adenosine triphosphate + NAD → Adenosine diphosphate + NADP
conversion direction: LEFT_TO_RIGHT

2.7.7.1,2.7.7.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000154/Stoichiometry/1.0
right: Nicotinamide ribotide
right: Adenosine monophosphate
spontaneous: false
EC number: 2.7.7.1,2.7.7.18
left: Water
left: NAD
name: NAD + Water ↔ Adenosine monophosphate + Nicotinamide ribotide
conversion direction: REVERSIBLE

3.-.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000681/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000154/Stoichiometry/1.0
right: Nicotinamide riboside
right: Phosphate
spontaneous: false
EC number: 3.-.-.-
left: Water
left: Nicotinamide ribotide
name: Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reaction179418
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040083/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000915/Stoichiometry/1.0
right: Nicotinic acid adenine dinucleotide
right: Pyrophosphate
spontaneous: false
left: nicotinate β-D-ribonucleotide
left: Adenosine triphosphate
name: Adenosine triphosphate + nicotinate β-D-ribonucleotide ↔ Nicotinic acid adenine dinucleotide + Pyrophosphate
conversion direction: REVERSIBLE

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C001086/Stoichiometry/1.0
type: Stoichiometry
physical entity: Niacinamide
stoichiometric coefficient: 1.0

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000191/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001086/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000681/Stoichiometry/1.0
right: Niacinamide
right: D-Ribose
spontaneous: false
EC number: 2.4.2.1
left: Water
left: Nicotinamide riboside
name: Nicotinamide riboside + Water ↔ D-Ribose + Niacinamide
conversion direction: REVERSIBLE

Nicotinic acid adenine dinucleotide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001179
xref: Reference/ChEBI CHEBI 18304
xref: Reference/CAS 6450-77-7
xref: Reference/ChemSpider 145043
xref: Reference/BioCyc DEAMIDO-NAD
xref: Reference/KEGG Compound C00857
xref: Reference/PubChem-compound 165491
chemical formula: C21H27N6O15P2
molecular weight: 665.10095
structure: ChemicalStructure/PW C000915

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01185
type: UnificationXref
id: C01185
db: KEGG Compound

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate

Reaction179419
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002943/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040083/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Phosphate
right: Nicotinate D-ribonucleoside
spontaneous: false
left: Water
left: nicotinate β-D-ribonucleotide
name: Water + nicotinate β-D-ribonucleotide → Nicotinate D-ribonucleoside + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15927
type: UnificationXref
id: CHEBI:15927
db: ChEBI

Reference/ChEBI CHEBI 47013
type: UnificationXref
id: CHEBI:47013
db: ChEBI

Compound/PW C000191/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribose
stoichiometric coefficient: 1.0

Nicotinic acid adenine dinucleotide
type: SmallMolecule
entity reference: Nicotinic acid adenine dinucleotide

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/ChemSpider 388373
type: UnificationXref
id: 388373
db: ChemSpider

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Compound/PW C002943/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinate D-ribonucleoside
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

ChemicalStructure/PW C000191
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@H](O)[C@@H]1O

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Dietary sources
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110228
pathway component: SubPathwayInteraction110228
name: SubPathway

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc NIACINE
type: UnificationXref
id: NIACINE
db: BioCyc

Uncharacterized protein, isoform F
type: Protein
cellular location: Nucleus
entity reference: Uncharacterized protein, isoform F

Adenosine triphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenosine triphosphate

NADP
type: SmallMolecule
cellular location: Nucleus
entity reference: NADP

Reference/HMDB HMDB0001179
type: UnificationXref
id: HMDB0001179
db: HMDB

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/BioCyc DEAMIDO-NAD
type: UnificationXref
id: DEAMIDO-NAD
db: BioCyc

Reference/CAS 98-92-0
type: UnificationXref
id: 98-92-0
db: CAS

Reference/PubChem-compound 439924
type: UnificationXref
id: 439924
db: PubChem-compound