Aldehyde oxidase
type: Complex
cellular location: Cytoplasm
component: Aldehyde oxidase 5
component: Aldehyde oxidase 6

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/KEGG Compound C00314
type: UnificationXref
id: C00314
db: KEGG Compound

ReactionCatalysis169605
type: Catalysis
controller: Pyridoxamine 5'-phosphate oxidase
controlled: Reaction179725
control type: ACTIVATION

ReactionCatalysis169604
type: Catalysis
controller: Pyridoxal phosphatase
controlled: Reaction179724
control type: ACTIVATION

ReactionCatalysis169603
type: Catalysis
controller: Pyridoxal kinase
controlled: Reaction179723
control type: ACTIVATION

ReactionCatalysis169602
type: Catalysis
controller: Pyridoxal phosphatase
controlled: Reaction179722
control type: ACTIVATION

ReactionCatalysis169601
type: Catalysis
controller: Pyridoxal kinase
controlled: Reaction179721
control type: ACTIVATION

ReactionCatalysis169600
type: Catalysis
controller: Pyridoxamine 5'-phosphate oxidase
controlled: Reaction179720
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Pyridoxal 5'-phosphate
type: SmallMolecule
entity reference: Pyridoxal 5'-phosphate

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/ChEBI CHEBI 28803
type: UnificationXref
id: CHEBI:28803
db: ChEBI

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Aldehyde oxidase 6
type: Protein
cellular location: Cytoplasm
entity reference: Aldehyde oxidase 6

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Pyridoxine 5'-phosphate
type: SmallMolecule
entity reference: Pyridoxine 5'-phosphate

Pyridoxine
type: SmallMolecule
entity reference: Pyridoxine

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 66-72-8
type: UnificationXref
id: 66-72-8
db: CAS

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Aldehyde oxidase 5
type: Protein
cellular location: Cytoplasm
entity reference: Aldehyde oxidase 5

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C001148/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Pyridoxine
type: SmallMoleculeReference
xref: Reference/CAS 65-23-6
xref: Reference/ChemSpider 1025
xref: Reference/KEGG Compound C00314
xref: Reference/BioCyc CPD-455
xref: Reference/HMDB HMDB0000239
xref: Reference/ChEBI CHEBI 16709
xref: Reference/PubChem-compound 1054
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000161

Excretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110087
pathway component: SubPathwayInteraction110087
name: SubPathway

Reference/ChemSpider 1026
type: UnificationXref
id: 1026
db: ChemSpider

Reference/ChemSpider 1025
type: UnificationXref
id: 1025
db: ChemSpider

Reference/ChemSpider 1024
type: UnificationXref
id: 1024
db: ChemSpider

Reference/UniProt B8A4Q2
type: UnificationXref
id: B8A4Q2
db: UniProt

Pyridoxal phosphatase
type: Complex
component: Phosphatase, orphan 2
component: Pyridoxal (pyridoxine, vitamin B6) phosphatase

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Pyridoxal phosphatase
type: Complex
cellular location: Cytoplasm
component: Pyridoxal (pyridoxine, vitamin B6) phosphatase
component: Phosphatase, orphan 2

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 6723
type: UnificationXref
id: 6723
db: PubChem-compound

Compound/PW C001017 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine 5'-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 1023
type: UnificationXref
id: 1023
db: ChemSpider

Reference/ChemSpider 1022
type: UnificationXref
id: 1022
db: ChemSpider

Reference/ChemSpider 1021
type: UnificationXref
id: 1021
db: ChemSpider

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/BioCyc PYRIDOXAL PHOSPHATE
type: UnificationXref
id: PYRIDOXAL_PHOSPHATE
db: BioCyc

Ammonia
type: SmallMolecule
entity reference: Ammonia

Pyridoxal kinase
type: Complex
component: Pyridoxal (pyridoxine, vitamin B6) kinase a
component: Novel protein similar to vertebrate pyridoxal (Pyridoxine, vitamin B6) kinase (PDXK)

4-Pyridoxic acid
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-1112
xref: Reference/HMDB HMDB0000017
xref: Reference/KEGG Compound C00847
xref: Reference/ChEBI CHEBI 17405
xref: Reference/ChemSpider 6467
xref: Reference/PubChem-compound 6723
xref: Reference/CAS 82-82-6
chemical formula: C8H9NO4
molecular weight: 183.05316
structure: ChemicalStructure/PW C000011

Reference/TAXONOMY 7955
type: UnificationXref
id: 7955
db: TAXONOMY

Reference/SMPDB SMP0121164
type: UnificationXref
id: SMP0121164
db: SMPDB

Compound/PW C001148 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Pyridoxamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001431
xref: Reference/ChEBI CHEBI 16410
xref: Reference/KEGG Compound C00534
xref: Reference/PubChem-compound 1052
xref: Reference/CAS 85-87-0
xref: Reference/ChemSpider 1023
xref: Reference/BioCyc PYRIDOXAMINE
chemical formula: C8H12N2O2
molecular weight: 168.08987
structure: ChemicalStructure/PW C001106

Novel protein similar to vertebrate pyridoxal (Pyridoxine, vitamin B6) kinase (PDXK)
type: ProteinReference
xref: Reference/UniProt B8A4Q2
organism: Danio rerio

Reference/CAS 529-96-4
type: UnificationXref
id: 529-96-4
db: CAS

Reference/BioCyc CPD-455
type: UnificationXref
id: CPD-455
db: BioCyc

Pyridoxal 5'-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyridoxal 5'-phosphate

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

ChemicalStructure/PW C000011
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CO)C(C(O)=O)=C1O

Reference/BioCyc PYRIDOXAMINE-5P
type: UnificationXref
id: PYRIDOXAMINE-5P
db: BioCyc

Pyridoxal
type: SmallMolecule
entity reference: Pyridoxal

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0001545
type: UnificationXref
id: HMDB0001545
db: HMDB

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/UniProt B0S7H1
type: UnificationXref
id: B0S7H1
db: UniProt

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

ReactionCatalysis169599
type: Catalysis
controller: Pyridoxamine 5'-phosphate oxidase
controlled: Reaction179719
control type: ACTIVATION

ReactionCatalysis169598
type: Catalysis
controller: Aldehyde oxidase
controlled: Reaction179718
control type: ACTIVATION

ChemicalStructure/PW C001106
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(O)C(CN)=C(CO)C=N1

Pyridoxine 5'-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyridoxine 5'-phosphate

ReactionCatalysis169597
type: Catalysis
controller: Pyridoxamine 5'-phosphate oxidase
controlled: Reaction179717
control type: ACTIVATION

ReactionCatalysis169596
type: Catalysis
controller: Pyridoxal phosphatase
controlled: Reaction179716
control type: ACTIVATION

ReactionCatalysis169595
type: Catalysis
controller: Pyridoxal kinase
controlled: Reaction179715
control type: ACTIVATION

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Phosphatase, orphan 2
type: Protein
entity reference: Phosphatase, orphan 2

Reference/HMDB HMDB0001431
type: UnificationXref
id: HMDB0001431
db: HMDB

Pyridoxal (pyridoxine, vitamin B6) phosphatase
type: Protein
entity reference: Pyridoxal (pyridoxine, vitamin B6) phosphatase

Pyridoxal (pyridoxine, vitamin B6) kinase a
type: Protein
entity reference: Pyridoxal (pyridoxine, vitamin B6) kinase a

Reference/HMDB HMDB0001555
type: UnificationXref
id: HMDB0001555
db: HMDB

Reference/KEGG Compound C00250
type: UnificationXref
id: C00250
db: KEGG Compound

Reference/UniProt F1Q5R8
type: UnificationXref
id: F1Q5R8
db: UniProt

Pyridoxamine 5'-phosphate oxidase
type: Protein
entity reference: Pyridoxamine 5'-phosphate oxidase

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Compound/PW C001188/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal
stoichiometric coefficient: 1.0

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Reaction179722
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001017/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000161/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Pyridoxine
right: Phosphate
spontaneous: false
left: Water
left: Pyridoxine 5'-phosphate
name: Pyridoxine 5'-phosphate + Water → Phosphate + Pyridoxine
conversion direction: LEFT_TO_RIGHT

Reaction179721
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000161 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001017 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Pyridoxine 5'-phosphate
right: Adenosine diphosphate
spontaneous: false
left: Pyridoxine
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyridoxine → Adenosine diphosphate + Pyridoxine 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00018
type: UnificationXref
id: C00018
db: KEGG Compound

Reaction179720
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000161/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188/Stoichiometry/1.0
right: Pyridoxal
right: Hydrogen peroxide
spontaneous: false
left: Pyridoxine
left: Oxygen
name: Oxygen + Pyridoxine ↔ Hydrogen peroxide + Pyridoxal
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 18335
type: UnificationXref
id: CHEBI:18335
db: ChEBI

Reaction179725
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001197/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Hydrogen peroxide
right: Ammonia
right: Pyridoxal 5'-phosphate
spontaneous: false
left: Water
left: Pyridoxamine 5'-phosphate
left: Oxygen
name: Oxygen + Pyridoxamine 5'-phosphate + Water → Ammonia + Hydrogen peroxide + Pyridoxal 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction179724
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001197/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Phosphate
right: Pyridoxamine
spontaneous: false
left: Water
left: Pyridoxamine 5'-phosphate
name: Pyridoxamine 5'-phosphate + Water → Phosphate + Pyridoxamine
conversion direction: LEFT_TO_RIGHT

Compound/PW C001783/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reaction179723
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001197/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Pyridoxamine 5'-phosphate
spontaneous: false
left: Adenosine triphosphate
left: Pyridoxamine
name: Adenosine triphosphate + Pyridoxamine → Adenosine diphosphate + Pyridoxamine 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0001319
type: UnificationXref
id: HMDB0001319
db: HMDB

Pyridoxine 5'-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 1026
xref: Reference/KEGG Compound C00627
xref: Reference/ChEBI CHEBI 28803
xref: Reference/HMDB HMDB0001319
xref: Reference/BioCyc PYRIDOXINE-5P
xref: Reference/PubChem-compound 1055
xref: Reference/CAS 447-05-2
chemical formula: C8H12NO6P
molecular weight: 249.04022
structure: ChemicalStructure/PW C001017

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen peroxide

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000239
type: UnificationXref
id: HMDB0000239
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/UniProt B3DI21
type: UnificationXref
id: B3DI21
db: UniProt

Reference/ChEBI CHEBI 16709
type: UnificationXref
id: CHEBI:16709
db: ChEBI

Reaction179715
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Pyridoxal 5'-phosphate
right: Adenosine diphosphate
spontaneous: false
left: Pyridoxal
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyridoxal → Adenosine diphosphate + Pyridoxal 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Pyridoxal 5'-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00018
xref: Reference/PubChem-compound 1051
xref: Reference/BioCyc PYRIDOXAL PHOSPHATE
xref: Reference/CAS 54-47-7
xref: Reference/ChEBI CHEBI 18405
xref: Reference/HMDB HMDB0001491
xref: Reference/ChemSpider 1022
chemical formula: C8H10NO6P
molecular weight: 247.02457
structure: ChemicalStructure/PW C001148

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Vitamin B6 Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2124352
pathway order: PathwayEnzymeReaction/2124340
pathway order: PathwayEnzymeReaction/2124332
pathway order: PathwayEnzymeReaction/2124342
pathway order: PathwaySubPathway/110087
pathway order: PathwayEnzymeReaction/2124333
pathway order: PathwayEnzymeReaction/2124336
pathway order: PathwayEnzymeReaction/2124337
pathway order: PathwayEnzymeReaction/2124359
pathway order: PathwayEnzymeReaction/2124350
pathway order: PathwayEnzymeReaction/2124361
pathway order: PathwayEnzymeReaction/2124360
pathway component: Reaction179722
pathway component: Reaction179721
pathway component: Reaction179720
pathway component: ReactionCatalysis169605
pathway component: Reaction179715
pathway component: ReactionCatalysis169604
pathway component: ReactionCatalysis169603
pathway component: Reaction179725
pathway component: ReactionCatalysis169602
pathway component: Reaction179724
pathway component: ReactionCatalysis169601
pathway component: Reaction179723
pathway component: ReactionCatalysis169600
pathway component: ReactionCatalysis169599
pathway component: ReactionCatalysis169598
pathway component: ReactionCatalysis169597
pathway component: ReactionCatalysis169596
pathway component: ReactionCatalysis169595
pathway component: Reaction179719
pathway component: Reaction179718
pathway component: Reaction179717
pathway component: Reaction179716
pathway component: Excretion
xref: Reference/SMPDB SMP0121164
xref: Reference/PathWhiz PW122452
organism: Danio rerio

Reference/BioCyc PYRIDOXAL
type: UnificationXref
id: PYRIDOXAL
db: BioCyc

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/CAS 54-47-7
type: UnificationXref
id: 54-47-7
db: CAS

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reaction179719
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Pyridoxal
right: Hydrogen peroxide
right: Ammonia
spontaneous: false
left: Water
left: Oxygen
left: Pyridoxamine
name: Oxygen + Pyridoxamine + Water ↔ Ammonia + Hydrogen peroxide + Pyridoxal
conversion direction: REVERSIBLE

Reaction179718
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000011 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytoplasm/Stoichiometry/1.0
right: Hydrogen peroxide
right: 4-Pyridoxic acid
spontaneous: false
left: Oxygen
left: Pyridoxal
left: Water
name: Oxygen + Pyridoxal + Water → 4-Pyridoxic acid + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reaction179717
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001017/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148/Stoichiometry/1.0
right: Hydrogen peroxide
right: Pyridoxal 5'-phosphate
spontaneous: false
left: Oxygen
left: Pyridoxine 5'-phosphate
name: Oxygen + Pyridoxine 5'-phosphate → Hydrogen peroxide + Pyridoxal 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction179716
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
right: Pyridoxal
right: Phosphate
spontaneous: false
left: Water
left: Pyridoxal 5'-phosphate
name: Pyridoxal 5'-phosphate + Water → Phosphate + Pyridoxal
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc PYRIDOXAMINE
type: UnificationXref
id: PYRIDOXAMINE
db: BioCyc

Reference/ChEBI CHEBI 16410
type: UnificationXref
id: CHEBI:16410
db: ChEBI

Phosphatase, orphan 2
type: ProteinReference
xref: Reference/UniProt A9JRB9
organism: Danio rerio

Pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: Reference/UniProt F1QQQ6

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Aldehyde oxidase 6
type: ProteinReference
xref: Reference/UniProt F1Q5R8
organism: Danio rerio

Aldehyde oxidase 5
type: ProteinReference
xref: Reference/UniProt M1ZMM0
organism: Danio rerio

ChemicalStructure/PW C001017
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(CO)=C1O

Pyridoxal (pyridoxine, vitamin B6) kinase a
type: ProteinReference
xref: Reference/UniProt B0S7H1
organism: Danio rerio

Pyridoxal (pyridoxine, vitamin B6) phosphatase
type: ProteinReference
xref: Reference/UniProt B3DI21
organism: Danio rerio

Water
type: SmallMolecule
entity reference: Water

Hydrogen peroxide
type: SmallMolecule
entity reference: Hydrogen peroxide

ChemicalStructure/PW C001148
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O

Reference/HMDB HMDB0000017
type: UnificationXref
id: HMDB0000017
db: HMDB

Pyridoxine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyridoxine

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/UniProt A9JRB9
type: UnificationXref
id: A9JRB9
db: UniProt

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/KEGG Compound C00847
type: UnificationXref
id: C00847
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 65-23-6
type: UnificationXref
id: 65-23-6
db: CAS

Pyridoxal
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyridoxal

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Danio rerio
type: BioSource
xref: Reference/TAXONOMY 7955

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/CAS 85-87-0
type: UnificationXref
id: 85-87-0
db: CAS

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 82-82-6
type: UnificationXref
id: 82-82-6
db: CAS

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Novel protein similar to vertebrate pyridoxal (Pyridoxine, vitamin B6) kinase (PDXK)
type: Protein
entity reference: Novel protein similar to vertebrate pyridoxal (Pyridoxine, vitamin B6) kinase (PDXK)

Pyridoxal
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1050
xref: Reference/CAS 66-72-8
xref: Reference/KEGG Compound C00250
xref: Reference/HMDB HMDB0001545
xref: Reference/ChEBI CHEBI 17310
xref: Reference/ChemSpider 1021
xref: Reference/BioCyc PYRIDOXAL
chemical formula: C8H9NO3
molecular weight: 167.05824
structure: ChemicalStructure/PW C001188

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C001106/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00627
type: UnificationXref
id: C00627
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Pyridoxamine 5'-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00647
xref: Reference/BioCyc PYRIDOXAMINE-5P
xref: Reference/HMDB HMDB0001555
xref: Reference/ChEBI CHEBI 18335
xref: Reference/ChemSpider 1024
xref: Reference/CAS 529-96-4
xref: Reference/PubChem-compound 1053
chemical formula: C8H13N2O5P
molecular weight: 248.05621
structure: ChemicalStructure/PW C001197

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Pyridoxal (pyridoxine, vitamin B6) kinase a
type: Protein
cellular location: Cytoplasm
entity reference: Pyridoxal (pyridoxine, vitamin B6) kinase a

Pyridoxamine 5'-phosphate
type: SmallMolecule
entity reference: Pyridoxamine 5'-phosphate

Reference/HMDB HMDB0001491
type: UnificationXref
id: HMDB0001491
db: HMDB

ChemicalStructure/PW C000161
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(O)C(CO)=C(CO)C=N1

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1050
type: UnificationXref
id: 1050
db: PubChem-compound

Reference/PubChem-compound 1051
type: UnificationXref
id: 1051
db: PubChem-compound

Reference/BioCyc CPD-1112
type: UnificationXref
id: CPD-1112
db: BioCyc

Novel protein similar to vertebrate pyridoxal (Pyridoxine, vitamin B6) kinase (PDXK)
type: Protein
cellular location: Cytoplasm
entity reference: Novel protein similar to vertebrate pyridoxal (Pyridoxine, vitamin B6) kinase (PDXK)

Reference/PubChem-compound 1052
type: UnificationXref
id: 1052
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C000161/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine
stoichiometric coefficient: 1.0

Pyridoxal (pyridoxine, vitamin B6) phosphatase
type: Protein
cellular location: Cytoplasm
entity reference: Pyridoxal (pyridoxine, vitamin B6) phosphatase

Reference/UniProt F1QQQ6
type: UnificationXref
id: F1QQQ6
db: UniProt

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1053
type: UnificationXref
id: 1053
db: PubChem-compound

Reference/PubChem-compound 1054
type: UnificationXref
id: 1054
db: PubChem-compound

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/PubChem-compound 1055
type: UnificationXref
id: 1055
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Pyridoxamine
type: SmallMolecule
entity reference: Pyridoxamine

ChemicalStructure/PW C001188
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CO)C(C=O)=C1O

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

4-Pyridoxic acid
type: SmallMolecule
entity reference: 4-Pyridoxic acid
name: SubPathwayInput

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Compound/PW C000161 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00647
type: UnificationXref
id: C00647
db: KEGG Compound

Compound/PW C001197/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxamine 5'-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 18405
type: UnificationXref
id: CHEBI:18405
db: ChEBI

Compound/PW C000011 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Pyridoxic acid
stoichiometric coefficient: 1.0

Compound/PW C001188 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17310
type: UnificationXref
id: CHEBI:17310
db: ChEBI

Pyridoxal kinase
type: Complex
cellular location: Cytoplasm
component: Novel protein similar to vertebrate pyridoxal (Pyridoxine, vitamin B6) kinase (PDXK)
component: Pyridoxal (pyridoxine, vitamin B6) kinase a

Phosphatase, orphan 2
type: Protein
cellular location: Cytoplasm
entity reference: Phosphatase, orphan 2

4-Pyridoxic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 4-Pyridoxic acid

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Compound/PW C001017/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine 5'-phosphate
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001197
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(CN)=C1O

Reference/CAS 447-05-2
type: UnificationXref
id: 447-05-2
db: CAS

Reference/UniProt M1ZMM0
type: UnificationXref
id: M1ZMM0
db: UniProt

Reference/KEGG Compound C00534
type: UnificationXref
id: C00534
db: KEGG Compound

Reference/ChEBI CHEBI 17405
type: UnificationXref
id: CHEBI:17405
db: ChEBI

Reference/BioCyc PYRIDOXINE-5P
type: UnificationXref
id: PYRIDOXINE-5P
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/ChemSpider 6467
type: UnificationXref
id: 6467
db: ChemSpider

SubPathwayInteraction110087
type: Interaction
name: SubPathway110087Reaction
name: SubPathwayReaction
participant: 4-Pyridoxic acid

Reference/PathWhiz PW122452
type: UnificationXref
id: PW122452
db: PathWhiz