Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C01089
type: UnificationXref
id: C01089
db: KEGG Compound

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Acetoacetyl-CoA
type: SmallMolecule
entity reference: Acetoacetyl-CoA
name: SubPathwayOutput
name: SubPathwayInput

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Succinic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinic acid

Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt A3KP84
type: UnificationXref
id: A3KP84
db: UniProt

Acetoacetic acid
type: SmallMolecule
entity reference: Acetoacetic acid

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetyl-CoA

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

(R)-3-Hydroxybutyric acid
type: SmallMoleculeReference
xref: Reference/CAS 625-72-9
xref: Reference/BioCyc CPD-335
xref: Reference/PubChem-compound 92135
xref: Reference/KEGG Compound C01089
xref: Reference/ChemSpider 83181
xref: Reference/HMDB HMDB0000011
xref: Reference/ChEBI CHEBI 17066
chemical formula: C4H8O3
molecular weight: 104.04734
structure: ChemicalStructure/PW C000006

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl-CoA

Reference/SMPDB SMP0121171
type: UnificationXref
id: SMP0121171
db: SMPDB

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (Hydroxymethylglutaricaciduria)
type: Protein
entity reference: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (Hydroxymethylglutaricaciduria)

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: Protein
entity reference: 3-hydroxy-3-methylglutaryl coenzyme A synthase

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/TAXONOMY 7955
type: UnificationXref
id: 7955
db: TAXONOMY

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA
name: SubPathwayOutput

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Compound/PW C000042/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Compound/PW C000006 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-3-Hydroxybutyric acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-335
type: UnificationXref
id: CPD-335
db: BioCyc

Synthesis and Degradation of Ketone Bodies
type: Pathway
pathway order: PathwayEnzymeReaction/2124461
pathway order: PathwayEnzymeReaction/2124454
pathway order: PathwayEnzymeReaction/2124446
pathway order: PathwayEnzymeReaction/2124445
pathway order: PathwaySubPathway/110105
pathway order: PathwaySubPathway/110103
pathway order: PathwayEnzymeReaction/2124470
pathway order: PathwaySubPathway/110102
pathway component: Reaction179755
pathway component: ReactionCatalysis169638
pathway component: 2.8.3.5
pathway component: ReactionCatalysis169636
pathway component: Reaction179757
pathway component: ReactionCatalysis169635
pathway component: 2.3.3.10
pathway component: ReactionCatalysis169634
pathway component: ReactionCatalysis169633
pathway component: 1.1.1.-,1.1.1.30
pathway component: Fatty acid degradation
pathway component: Pyruvate metabolism
pathway component: Glycolysis
xref: Reference/PathWhiz PW122459
xref: Reference/SMPDB SMP0121171
organism: Danio rerio

ChemicalStructure/PW C000006
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)CC(O)=O

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Acetoacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetoacetic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

3-hydroxybutyrate dehydrogenase type 2
type: Protein
cellular location: Cytoplasm
entity reference: 3-hydroxybutyrate dehydrogenase type 2

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Reference/ChemSpider 83181
type: UnificationXref
id: 83181
db: ChemSpider

SubPathwayInteraction110105
type: Interaction
name: SubPathwayReaction
name: SubPathway110105Reaction
participant: Acetyl-CoA

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

SubPathwayInteraction110103
type: Interaction
name: SubPathway110103Reaction
name: SubPathwayReaction
participant: Acetoacetyl-CoA

SubPathwayInteraction110102
type: Interaction
name: SubPathwayReaction
name: SubPathway110102Reaction
participant: Acetoacetyl-CoA

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Zgc:163053 protein
type: Protein
cellular location: Cytoplasm
entity reference: Zgc:163053 protein

Succinyl-CoA:3-ketoacid-coenzyme A transferase
type: Protein
cellular location: Mitochondrion
entity reference: Succinyl-CoA:3-ketoacid-coenzyme A transferase

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Reference/UniProt Q7ZU18
type: UnificationXref
id: Q7ZU18
db: UniProt

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinyl-CoA

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/UniProt Q7ZV32
type: UnificationXref
id: Q7ZV32
db: UniProt

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/UniProt Q6AZB2
type: UnificationXref
id: Q6AZB2
db: UniProt

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Compound/PW C000808 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

(R)-3-Hydroxybutyric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: (R)-3-Hydroxybutyric acid

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17066
type: UnificationXref
id: CHEBI:17066
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Acetoacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetic acid

Reference/HMDB HMDB0000011
type: UnificationXref
id: HMDB0000011
db: HMDB

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/UniProt Q561X9
type: UnificationXref
id: Q561X9
db: UniProt

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Danio rerio
type: BioSource
xref: Reference/TAXONOMY 7955

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Compound/PW C001142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

1.1.1.-,1.1.1.30
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000042 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000006 Cytoplasm/Stoichiometry/1.0
right: (R)-3-Hydroxybutyric acid
right: NAD
spontaneous: false
EC number: 1.1.1.-,1.1.1.30
left: Acetoacetic acid
left: Hydrogen Ion
left: NADH
name: Acetoacetic acid + Hydrogen Ion + NADH ↔ (R)-3-Hydroxybutyric acid + NAD
conversion direction: REVERSIBLE

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Acat2 protein
type: Protein
cellular location: Mitochondrion
entity reference: Acat2 protein

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Reaction179755
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
name: 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

2.8.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000808 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
right: Succinyl-CoA
right: Acetoacetic acid
spontaneous: false
EC number: 2.8.3.5
left: Acetoacetyl-CoA
left: Succinic acid
name: Acetoacetyl-CoA + Succinic acid ↔ Acetoacetic acid + Succinyl-CoA
conversion direction: REVERSIBLE

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reaction179757
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063/Stoichiometry/1.0
right: Acetoacetic acid
right: Acetyl-CoA
spontaneous: false
left: 3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA → Acetoacetic acid + Acetyl-CoA
conversion direction: LEFT_TO_RIGHT

2.3.3.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063/Stoichiometry/1.0
right: Coenzyme A
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
EC number: 2.3.3.10
left: Water
left: Acetoacetyl-CoA
left: Acetyl-CoA
name: Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (Hydroxymethylglutaricaciduria)
type: ProteinReference
xref: Reference/UniProt Q7ZV32
organism: Danio rerio

Succinyl-CoA:3-ketoacid-coenzyme A transferase
type: ProteinReference
xref: Reference/UniProt Q6AZB2
organism: Danio rerio

Zgc:163053 protein
type: ProteinReference
xref: Reference/UniProt A3KP84
organism: Danio rerio

3-hydroxybutyrate dehydrogenase type 2
type: ProteinReference
xref: Reference/UniProt Q561X9
organism: Danio rerio

Acat2 protein
type: ProteinReference
xref: Reference/UniProt Q7ZU18
organism: Danio rerio

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
organism: Danio rerio

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/PathWhiz PW122459
type: UnificationXref
id: PW122459
db: PathWhiz

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Compound/PW C000042 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/CAS 625-72-9
type: UnificationXref
id: 625-72-9
db: CAS

Reference/PubChem-compound 92135
type: UnificationXref
id: 92135
db: PubChem-compound

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ReactionCatalysis169638
type: Catalysis
controller: 3-hydroxybutyrate dehydrogenase
controlled: 1.1.1.-,1.1.1.30
control type: ACTIVATION

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ReactionCatalysis169636
type: Catalysis
controller: Succinyl-CoA:3-ketoacid-coenzyme A transferase
controlled: 2.8.3.5
control type: ACTIVATION

ReactionCatalysis169635
type: Catalysis
controller: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (Hydroxymethylglutaricaciduria)
controlled: Reaction179757
control type: ACTIVATION

ReactionCatalysis169634
type: Catalysis
controller: 3-hydroxy-3-methylglutaryl coenzyme A synthase
controlled: 2.3.3.10
control type: ACTIVATION

ReactionCatalysis169633
type: Catalysis
controller: Acat2 protein
controlled: Reaction179755
control type: ACTIVATION

3-hydroxybutyrate dehydrogenase
type: Complex
cellular location: Cytoplasm
component: 3-hydroxybutyrate dehydrogenase type 2
component: Zgc:163053 protein

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Compound/PW C000042 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Compound/PW C001063/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Fatty acid degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110102
pathway component: SubPathwayInteraction110102
name: SubPathway

Pyruvate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110103
pathway component: SubPathwayInteraction110103
name: SubPathway

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110105
pathway component: SubPathwayInteraction110105
name: SubPathway

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD