Compound/PW C001039 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/UniProt Q9C6T1
type: UnificationXref
id: Q9C6T1
db: UniProt

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ReactionCatalysis169961
type: Catalysis
controller: Isopentenyl phosphate kinase
controlled: 2.7.4.26
control type: ACTIVATION

Reference/BioCyc MEVALONATE
type: UnificationXref
id: MEVALONATE
db: BioCyc

ReactionCatalysis169960
type: Catalysis
controller: Diphosphomevalonate decarboxylase MVD1, peroxisomal
controlled: 4.1.1.33
control type: ACTIVATION

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Compound/PW C001316 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001981
type: UnificationXref
id: HMDB0001981
db: HMDB

Reference/UniProt Q8H1F7
type: UnificationXref
id: Q8H1F7
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayOutput

Mevalonic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25351
xref: Reference/PubChem-compound 449
xref: Reference/CAS 150-97-0
xref: Reference/KEGG Compound C00418
xref: Reference/HMDB HMDB0000227
xref: Reference/BioCyc MEVALONATE
xref: Reference/ChemSpider 436
chemical formula: C6H12O4
molecular weight: 148.07356
structure: ChemicalStructure/PW C000152

ReactionCatalysis169959
type: Catalysis
controller: Phosphomevalonate kinase, peroxisomal
controlled: 2.7.4.2
control type: ACTIVATION

ReactionCatalysis169958
type: Catalysis
controller: Mevalonate kinase
controlled: 2.7.1.36
control type: ACTIVATION

ReactionCatalysis169957
type: Catalysis
controller: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
controlled: 1.1.1.34
control type: ACTIVATION

ReactionCatalysis169956
type: Catalysis
controller: hydroxymethylglutaryl-CoA synthase
controlled: Reaction180101
control type: ACTIVATION

ReactionCatalysis169955
type: Catalysis
controller: acetyl-CoA C-acetyltransferase
controlled: Reaction180100
control type: ACTIVATION

ReactionCatalysis169953
type: Catalysis
controller: Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
controlled: 5.3.3.2
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ReactionCatalysis169952
type: Catalysis
controller: Geranylgeranyl pyrophosphate synthase 6, mitochondrial
controlled: 2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
control type: ACTIVATION

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Monoterpenoid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110203
pathway component: SubPathwayInteraction110203
xref: Reference/SMPDB SMP0014204
xref: Reference/PathWhiz PW015068
name: SubPathway

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Carbon dioxide
type: SmallMolecule
cellular location: Peroxisome
entity reference: Carbon dioxide

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/UniProt P54873
type: UnificationXref
id: P54873
db: UniProt

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/UniProt O23722
type: UnificationXref
id: O23722
db: UniProt

Reference/CAS 358-72-5
type: UnificationXref
id: 358-72-5
db: CAS

Diphosphomevalonate decarboxylase MVD1, peroxisomal
type: Protein
cellular location: Peroxisome
entity reference: Diphosphomevalonate decarboxylase MVD1, peroxisomal

Compound/PW C001099 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Isopentenyl-diphosphate Delta-isomerase II, chloroplastic

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt P14891
type: UnificationXref
id: P14891
db: UniProt

Compound/PW C001039 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/GENE ONTOLOGY GO 0009507
type: UnificationXref
id: GO:0009507
db: GENE ONTOLOGY

Reference/PathWhiz PW000839
type: UnificationXref
id: PW000839
db: PathWhiz

Compound/PW C000993 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Geranyl-PP
stoichiometric coefficient: 1.0

2.7.4.26
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001039 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104755 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: Isopentenyl phosphate
spontaneous: false
EC number: 2.7.4.26
left: Adenosine diphosphate
left: Isopentenyl pyrophosphate
name: Adenosine diphosphate + Isopentenyl pyrophosphate ← Adenosine triphosphate + Isopentenyl phosphate
conversion direction: RIGHT_TO_LEFT

4.1.1.33
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001327 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001039 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Peroxisome/Stoichiometry/1.0
right: Phosphate
right: Carbon dioxide
right: Adenosine diphosphate
right: Isopentenyl pyrophosphate
spontaneous: false
EC number: 4.1.1.33
left: Adenosine triphosphate
left: (R)-Mevalonic acid-5-pyrophosphate
name: (R)-Mevalonic acid-5-pyrophosphate + Adenosine triphosphate → Adenosine diphosphate + Carbon dioxide + Isopentenyl pyrophosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

1.1.1.34
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000152 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
right: Mevalonic acid
right: Coenzyme A
right: NADP
spontaneous: false
EC number: 1.1.1.34
left: NADPH
left: 3-Hydroxy-3-methylglutaryl-CoA
left: Hydrogen Ion
name: 3-Hydroxy-3-methylglutaryl-CoA + 2 Hydrogen Ion + 2 NADPH → Coenzyme A + Mevalonic acid + 2 NADP
conversion direction: LEFT_TO_RIGHT

Reaction180101
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: Hydrogen Ion
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
left: Acetoacetyl-CoA
left: Acetyl-CoA
left: Water
name: Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110202
pathway component: SubPathwayInteraction110202
xref: Reference/SMPDB SMP0000859
xref: Reference/PathWhiz PW000839
name: SubPathway

2.7.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001036 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001327 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Peroxisome/Stoichiometry/1.0
right: (R)-Mevalonic acid-5-pyrophosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.2
left: Mevalonic acid-5P
left: Adenosine triphosphate
name: Adenosine triphosphate + Mevalonic acid-5P → (R)-Mevalonic acid-5-pyrophosphate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001036 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000152 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Mevalonic acid-5P
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.36
left: Adenosine triphosphate
left: Mevalonic acid
name: Adenosine triphosphate + Mevalonic acid → Adenosine diphosphate + Hydrogen Ion + Mevalonic acid-5P
conversion direction: LEFT_TO_RIGHT

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/KEGG Compound C00341
type: UnificationXref
id: C00341
db: KEGG Compound

Reference/ChEBI CHEBI 17211
type: UnificationXref
id: CHEBI:17211
db: ChEBI

Compound/PW C001142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Adenosine triphosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Adenosine triphosphate

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reaction180100
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: Acetoacetyl-CoA
spontaneous: false
left: Acetyl-CoA
name: Acetyl-CoA → Acetoacetyl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Phosphomevalonate kinase, peroxisomal
type: Protein
cellular location: Peroxisome
entity reference: Phosphomevalonate kinase, peroxisomal

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 449
type: UnificationXref
id: 449
db: PubChem-compound

Mevalonic acid-5P
type: SmallMolecule
cellular location: Peroxisome
entity reference: Mevalonic acid-5P

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

(R)-Mevalonic acid-5-pyrophosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: (R)-Mevalonic acid-5-pyrophosphate

Isopentenyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00129
xref: Reference/ChemSpider 1158
xref: Reference/PubChem-compound 1195
xref: Reference/CAS 358-71-4
xref: Reference/HMDB HMDB0001347
xref: Reference/ChEBI CHEBI 16584
chemical formula: C5H12O7P2
molecular weight: 246.00583
structure: ChemicalStructure/PW C001039

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

Reference/KEGG Compound C00235
type: UnificationXref
id: C00235
db: KEGG Compound

Reference/ChEBI CHEBI 16057
type: UnificationXref
id: CHEBI:16057
db: ChEBI

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Geranyl-PP
type: SmallMoleculeReference
xref: Reference/BioCyc GERANYL-PP
xref: Reference/CAS 763-10-0
xref: Reference/KEGG Compound C00341
xref: Reference/PubChem-compound 445995
xref: Reference/HMDB HMDB0001285
xref: Reference/ChEBI CHEBI 17211
xref: Reference/ChemSpider 393471
chemical formula: C10H20O7P2
molecular weight: 314.06842
structure: ChemicalStructure/PW C000993

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/PubChem-compound 22833574
type: UnificationXref
id: 22833574
db: PubChem-compound

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00129
type: UnificationXref
id: C00129
db: KEGG Compound

Reference/ChemSpider 1158
type: UnificationXref
id: 1158
db: ChemSpider

Reference/SMPDB SMP0000859
type: UnificationXref
id: SMP0000859
db: SMPDB

Compound/PW C001036 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid-5P
stoichiometric coefficient: 1.0

Isopentenyl phosphate kinase
type: Protein
cellular location: Cytosol
entity reference: Isopentenyl phosphate kinase

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Dimethylallylpyrophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-4211
xref: Reference/PubChem-compound 647
xref: Reference/CAS 358-72-5
xref: Reference/ChemSpider 627
xref: Reference/HMDB HMDB0001120
xref: Reference/KEGG Compound C00235
xref: Reference/ChEBI CHEBI 16057
chemical formula: C5H12O7P2
molecular weight: 246.00583
structure: ChemicalStructure/PW C000874

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/SMPDB SMP0014204
type: UnificationXref
id: SMP0014204
db: SMPDB

Dimethylallylpyrophosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dimethylallylpyrophosphate

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/PathWhiz PW122503
type: UnificationXref
id: PW122503
db: PathWhiz

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Compound/PW C001104 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetoacetyl-CoA

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 150-97-0
type: UnificationXref
id: 150-97-0
db: CAS

Compound/PW C000170 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000227
type: UnificationXref
id: HMDB0000227
db: HMDB

Reference/ChemSpider 393471
type: UnificationXref
id: 393471
db: ChemSpider

Reference/UniProt O22043
type: UnificationXref
id: O22043
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Acetyl-CoA acetyltransferase, cytosolic 1
type: Protein
cellular location: Cytosol
entity reference: Acetyl-CoA acetyltransferase, cytosolic 1

Reference/KEGG Compound C01107
type: UnificationXref
id: C01107
db: KEGG Compound

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Isopentenyl pyrophosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Isopentenyl pyrophosphate

Reference/CAS 763-10-0
type: UnificationXref
id: 763-10-0
db: CAS

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Compound/PW C104755 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl phosphate
stoichiometric coefficient: 1.0

Geranyl-PP
type: SmallMolecule
entity reference: Geranyl-PP
name: SubPathwayInput

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt Q9FIK7
type: UnificationXref
id: Q9FIK7
db: UniProt

Coenzyme A
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Coenzyme A

ChemicalStructure/PW C001327
type: ChemicalStructure
structure format: SMILES
structure data: C[C@](O)(CCOP(O)(=O)OP(O)(O)=O)CC(O)=O

Reference/PubChem-compound 445995
type: UnificationXref
id: 445995
db: PubChem-compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/UniProt Q8S4Y1
type: UnificationXref
id: Q8S4Y1
db: UniProt

Reference/PubChem-compound 439400
type: UnificationXref
id: 439400
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Mevalonic acid-5P
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439400
xref: Reference/HMDB HMDB0001343
xref: Reference/ChEBI CHEBI 17436
xref: Reference/KEGG Compound C01107
xref: Reference/BioCyc CPD-499
xref: Reference/ChemSpider 388517
xref: Reference/CAS 73566-35-5
chemical formula: C6H13O7P
molecular weight: 228.03989
structure: ChemicalStructure/PW C001036

Isopentenyl phosphate
type: SmallMoleculeReference
chemical formula: C5H11O4P
molecular weight: 166.03949
structure: ChemicalStructure/PW C104755

Reference/BioCyc CPD-499
type: UnificationXref
id: CPD-499
db: BioCyc

Reference/PubChem-compound 647
type: UnificationXref
id: 647
db: PubChem-compound

Reference/ChemSpider 388517
type: UnificationXref
id: 388517
db: ChemSpider

Reference/UniProt Q42553
type: UnificationXref
id: Q42553
db: UniProt

Compound/PW C001063 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

Isopentenyl pyrophosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Isopentenyl pyrophosphate

Phosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Phosphate

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/HMDB HMDB0001343
type: UnificationXref
id: HMDB0001343
db: HMDB

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Peroxisome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005777

Mevalonic acid-5P
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Mevalonic acid-5P

Reference/HMDB HMDB0001347
type: UnificationXref
id: HMDB0001347
db: HMDB

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc GERANYL-PP
type: UnificationXref
id: GERANYL-PP
db: BioCyc

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/UniProt P46086
type: UnificationXref
id: P46086
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Adenosine diphosphate

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ChemicalStructure/PW C001036
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@](O)(CCOP(O)(O)=O)CC(O)=O

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

hydroxymethylglutaryl-CoA synthase
type: ProteinReference
xref: Reference/UniProt P54873
organism: Arabidopsis thaliana

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Mevalonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Mevalonic acid

Reference/CAS 1492-08-6
type: UnificationXref
id: 1492-08-6
db: CAS

Geranyl-PP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Geranyl-PP

Mevalonate kinase
type: Protein
cellular location: Cytoplasm
entity reference: Mevalonate kinase

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Diphosphomevalonate decarboxylase MVD1, peroxisomal
type: ProteinReference
xref: Reference/UniProt O23722
organism: Arabidopsis thaliana

Isopentenyl phosphate kinase
type: ProteinReference
xref: Reference/UniProt Q8H1F7
organism: Arabidopsis thaliana

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Isopentenyl phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Isopentenyl phosphate

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q42553
organism: Arabidopsis thaliana

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
type: ProteinReference
xref: Reference/UniProt P14891
organism: Arabidopsis thaliana

Mevalonate kinase
type: ProteinReference
xref: Reference/UniProt P46086
organism: Arabidopsis thaliana

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 436
type: UnificationXref
id: 436
db: ChemSpider

Phosphomevalonate kinase, peroxisomal
type: ProteinReference
xref: Reference/UniProt Q9C6T1
organism: Arabidopsis thaliana

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

Reference/ChEBI CHEBI 25351
type: UnificationXref
id: CHEBI:25351
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

ChemicalStructure/PW C000152
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)(CCO)CC(O)=O

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Geranylgeranyl pyrophosphate synthase 6, mitochondrial
type: ProteinReference
xref: Reference/UniProt O22043
organism: Arabidopsis thaliana

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/PathWhiz PW015068
type: UnificationXref
id: PW015068
db: PathWhiz

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0001120
type: UnificationXref
id: HMDB0001120
db: HMDB

Isopentenyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Isopentenyl pyrophosphate

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Reference/BioCyc CPD-4211
type: UnificationXref
id: CPD-4211
db: BioCyc

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C001039 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

SubPathwayInteraction110203
type: Interaction
name: SubPathwayReaction
name: SubPathway110203Reaction
participant: Geranyl-PP

SubPathwayInteraction110202
type: Interaction
name: SubPathway110202Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

Reference/CAS 73566-35-5
type: UnificationXref
id: 73566-35-5
db: CAS

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C001036 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid-5P
stoichiometric coefficient: 1.0

Dimethylallylpyrophosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Dimethylallylpyrophosphate

Reference/GENE ONTOLOGY GO 0005777
type: UnificationXref
id: GO:0005777
db: GENE ONTOLOGY

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0121209
type: UnificationXref
id: SMP0121209
db: SMPDB

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Probable acetyl-CoA acetyltransferase, cytosolic 2
type: Protein
cellular location: Cytosol
entity reference: Probable acetyl-CoA acetyltransferase, cytosolic 2

Compound/PW C000874 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylallylpyrophosphate
stoichiometric coefficient: 1.0

Reference/CAS 358-71-4
type: UnificationXref
id: 358-71-4
db: CAS

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C000152 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid
stoichiometric coefficient: 1.0

Probable acetyl-CoA acetyltransferase, cytosolic 2
type: ProteinReference
xref: Reference/UniProt Q9FIK7
organism: Arabidopsis thaliana

5.3.3.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000874 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001039 Chloroplast/Stoichiometry/1.0
right: Dimethylallylpyrophosphate
spontaneous: false
EC number: 5.3.3.2
left: Isopentenyl pyrophosphate
name: Isopentenyl pyrophosphate ↔ Dimethylallylpyrophosphate
conversion direction: REVERSIBLE

Mevalonate Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2125066
pathway order: PathwayEnzymeReaction/2125069
pathway order: PathwayEnzymeReaction/2125068
pathway order: PathwayEnzymeReaction/2125059
pathway order: PathwayEnzymeReaction/2125061
pathway order: PathwayEnzymeReaction/2125060
pathway order: PathwayEnzymeReaction/2125063
pathway order: PathwayEnzymeReaction/2125062
pathway order: PathwaySubPathway/110203
pathway order: PathwayEnzymeReaction/2125065
pathway order: PathwaySubPathway/110202
pathway component: 2.7.4.26
pathway component: ReactionCatalysis169959
pathway component: 4.1.1.33
pathway component: ReactionCatalysis169958
pathway component: ReactionCatalysis169957
pathway component: ReactionCatalysis169956
pathway component: 1.1.1.34
pathway component: ReactionCatalysis169955
pathway component: Reaction180101
pathway component: Glycolysis
pathway component: 2.7.4.2
pathway component: 2.7.1.36
pathway component: ReactionCatalysis169953
pathway component: ReactionCatalysis169952
pathway component: ReactionCatalysis169961
pathway component: ReactionCatalysis169960
pathway component: Monoterpenoid Biosynthesis
pathway component: 5.3.3.2
pathway component: 2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
pathway component: Reaction180100
xref: Reference/PathWhiz PW122503
xref: Reference/SMPDB SMP0121209
organism: Arabidopsis thaliana

Acetyl-CoA acetyltransferase, cytosolic 1
type: ProteinReference
xref: Reference/UniProt Q8S4Y1
organism: Arabidopsis thaliana

2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001039 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000993 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000874 Mitochondrion/Stoichiometry/1.0
right: Pyrophosphate
right: Geranyl-PP
spontaneous: false
EC number: 2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
left: Dimethylallylpyrophosphate
left: Isopentenyl pyrophosphate
name: Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

Compound/PW C000874 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylallylpyrophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17436
type: UnificationXref
id: CHEBI:17436
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyrophosphate

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Chloroplast
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0009507

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

(R)-Mevalonic acid-5-pyrophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001981
xref: Reference/ChemSpider 17216150
xref: Reference/CAS 1492-08-6
xref: Reference/PubChem-compound 22833574
chemical formula: C6H14O10P2
molecular weight: 308.00623
structure: ChemicalStructure/PW C001327

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000414 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16584
type: UnificationXref
id: CHEBI:16584
db: ChEBI

Geranylgeranyl pyrophosphate synthase 6, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Geranylgeranyl pyrophosphate synthase 6, mitochondrial

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C001039 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C001034 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C104755
type: ChemicalStructure
structure format: SMILES
structure data: CC(=C)CCOP(O)(O)=O

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 1195
type: UnificationXref
id: 1195
db: PubChem-compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Mevalonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Mevalonic acid

Compound/PW C001327 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-Mevalonic acid-5-pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00418
type: UnificationXref
id: C00418
db: KEGG Compound

ChemicalStructure/PW C001039
type: ChemicalStructure
structure format: SMILES
structure data: CC(=C)CCOP(O)(=O)OP(O)(O)=O

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/ChemSpider 17216150
type: UnificationXref
id: 17216150
db: ChemSpider

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000993
type: ChemicalStructure
structure format: SMILES

Compound/PW C000152 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001285
type: UnificationXref
id: HMDB0001285
db: HMDB

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

acetyl-CoA C-acetyltransferase
type: Complex
cellular location: Cytosol
component: Acetyl-CoA acetyltransferase, cytosolic 1
component: Probable acetyl-CoA acetyltransferase, cytosolic 2

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 627
type: UnificationXref
id: 627
db: ChemSpider

ChemicalStructure/PW C000874
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)=CCO[P@](O)(=O)OP(O)(O)=O

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

hydroxymethylglutaryl-CoA synthase
type: Protein
cellular location: Cytosol
entity reference: hydroxymethylglutaryl-CoA synthase

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 2.0

Compound/PW C001063 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Isopentenyl pyrophosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Isopentenyl pyrophosphate