Reaction180216
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001904 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000169 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001938 Cytoplasm/Stoichiometry/1.0
right: Thyroxine
right: Water
right: 2-Aminoacrylic acid
spontaneous: false
left: Hydrogen peroxide
left: 3,5-Diiodo-L-tyrosine
name: 2 3,5-Diiodo-L-tyrosine + Hydrogen peroxide → 2-Aminoacrylic acid + Thyroxine + 2 Water
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reaction180218
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001904 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000014 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000532 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040071 Cytoplasm/Stoichiometry/1.0
right: I(-)
right: 3,5-Diiodo-L-tyrosine
spontaneous: false
left: Iodotyrosine
left: Iodine
name: Iodine + Iodotyrosine → 3,5-Diiodo-L-tyrosine + I(-)
conversion direction: LEFT_TO_RIGHT

Reaction180214
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001904 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000181 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000014 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001938 Cytoplasm/Stoichiometry/1.0
right: Water
right: Liothyronine
right: 2-Aminoacrylic acid
spontaneous: false
left: Iodotyrosine
left: Hydrogen peroxide
left: 3,5-Diiodo-L-tyrosine
name: 3,5-Diiodo-L-tyrosine + Hydrogen peroxide + Iodotyrosine → 2-Aminoacrylic acid + Liothyronine + 2 Water
conversion direction: LEFT_TO_RIGHT

Reaction180213
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000014 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000532 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040071 Cytoplasm/Stoichiometry/1.0
right: Iodotyrosine
right: I(-)
spontaneous: false
left: Iodine
left: L-Tyrosine
name: Iodine + L-Tyrosine → I(-) + Iodotyrosine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 123991
type: UnificationXref
id: 123991
db: PubChem-compound

Reaction180219
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000210/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000103/Stoichiometry/1.0
right: Tyramine
right: Carbon dioxide
spontaneous: false
left: L-Tyrosine
name: L-Tyrosine → Carbon dioxide + Tyramine
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/UniProt Q7SZR0
type: UnificationXref
id: Q7SZR0
db: UniProt

Reference/CAS 775-01-9
type: UnificationXref
id: 775-01-9
db: CAS

Reference/ChEBI CHEBI 846276
type: UnificationXref
id: CHEBI:846276
db: ChEBI

Reaction1126
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000952/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002044/Stoichiometry/1.0
right: Leucodopachrome
spontaneous: false
left: Dopaquinone
name: Dopaquinone → Leucodopachrome
conversion direction: LEFT_TO_RIGHT

Reaction180238
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002411/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000074/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Homovanillic acid
right: Hydrogen Ion
right: NADPH
spontaneous: false
left: Water
left: Homovanillin
left: NADP
name: Homovanillin + NADP + Water → Homovanillic acid + Hydrogen Ion + NADPH
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00218
type: UnificationXref
id: C00218
db: KEGG Compound

Reaction180237
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002411 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000015 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: Homovanillin
right: Hydrogen peroxide
spontaneous: false
left: Water
left: 3-Methoxytyramine
left: Oxygen
name: 3-Methoxytyramine + Oxygen + Water → Ammonia + Homovanillin + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reaction180239
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001969/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: 3,4-Dihydroxybenzeneacetic acid
spontaneous: false
left: Water
left: 3,4-Dihydroxyphenylacetaldehyde
left: NAD
name: 3,4-Dihydroxyphenylacetaldehyde + NAD + Water → 3,4-Dihydroxybenzeneacetic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reaction180234
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
right: Carbon dioxide
spontaneous: false
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

Reaction180233
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000448/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000952/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104791/Stoichiometry/1.0
right: Cysteinyldopa
spontaneous: true
left: Dopaquinone
left: L-Cysteine
name: Dopaquinone + L-Cysteine → Cysteinyldopa
conversion direction: LEFT_TO_RIGHT

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000015/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: 3-Methoxytyramine
spontaneous: false
EC number: 2.1.1.6
left: Dopamine
left: S-Adenosylmethionine
name: Dopamine + S-Adenosylmethionine → 3-Methoxytyramine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 44747
type: UnificationXref
id: CHEBI:44747
db: ChEBI

Reaction180235
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001969 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: 3,4-Dihydroxyphenylacetaldehyde
right: Hydrogen peroxide
spontaneous: false
left: Water
left: Dopamine
left: Oxygen
name: Dopamine + Oxygen + Water → 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 23224
type: UnificationXref
id: 23224
db: ChemSpider

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/PubChem-compound 736172
type: UnificationXref
id: 736172
db: PubChem-compound

Reaction180230
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000952/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000103/Stoichiometry/1.0
right: Water
right: Dopaquinone
right: L-Dopa
spontaneous: false
left: Oxygen
left: L-Tyrosine
left: L-Dopa
name: L-Dopa + L-Tyrosine + Oxygen → Dopaquinone + L-Dopa + Water
conversion direction: LEFT_TO_RIGHT

I(-)
type: SmallMoleculeReference
xref: Reference/CAS 10034-85-2
xref: Reference/PubChem-compound 21844680
xref: Reference/KEGG Compound C05590
xref: Reference/HMDB HMDB0059634
xref: Reference/ChEBI CHEBI 43451
xref: Reference/ChemSpider 23224
chemical formula: HI
molecular weight: 127.91229
structure: ChemicalStructure/PW C040071

Reaction180232
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000103/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
right: L-Dopa
spontaneous: false
left: Oxygen
left: L-Tyrosine
name: 2 L-Tyrosine + Oxygen → L-Dopa
conversion direction: LEFT_TO_RIGHT

Compound/PW C000052 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reaction180231
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001105/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000952/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002044/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117/Stoichiometry/1.0
right: L-Dopachrome
right: L-Dopa
spontaneous: true
left: Leucodopachrome
left: Dopaquinone
name: Dopaquinone + Leucodopachrome → L-Dopa + L-Dopachrome
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 7955
type: UnificationXref
id: 7955
db: TAXONOMY

3,5-Diiodo-L-tyrosine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01060
xref: Reference/CAS 300-39-0 66-02-4
xref: Reference/PubChem-compound 7058163
xref: Reference/ChemSpider 8946
xref: Reference/ChEBI CHEBI 15768
xref: Reference/BioCyc DIIODO-L-TYROSINE
xref: Reference/HMDB HMDB0003474
chemical formula: C9H9I2NO3
molecular weight: 432.8672
structure: ChemicalStructure/PW C001904

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Glutamic acid

Reaction180227
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104789/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
right: Fumaric acid
right: Pyruvic acid
spontaneous: false
left: 3-Fumarylpyruvate
left: Water
name: 3-Fumarylpyruvate + Water → Fumaric acid + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 1506
type: UnificationXref
id: CHEBI:1506
db: ChEBI

Reference/CAS 490-79-9
type: UnificationXref
id: 490-79-9
db: CAS

3.7.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000088 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000981 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Cytosol/Stoichiometry/1.0
right: Acetoacetic acid
right: Fumaric acid
spontaneous: false
EC number: 3.7.1.2
left: 4-Fumarylacetoacetic acid
left: Water
name: 4-Fumarylacetoacetic acid + Water → Acetoacetic acid + Fumaric acid
conversion direction: LEFT_TO_RIGHT

Reaction180229
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002042 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000099 Cytosol/Stoichiometry/1.0
right: Gentisic acid
right: Hydrogen peroxide
spontaneous: false
left: Oxygen
left: Gentisate aldehyde
left: Water
name: Gentisate aldehyde + Oxygen + Water → Gentisic acid + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reaction180228
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000084/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002042/Stoichiometry/1.0
right: Water
right: Gentisate aldehyde
right: Carbon dioxide
spontaneous: false
left: Homogentisic acid
left: Oxygen
name: Homogentisic acid + Oxygen → Carbon dioxide + Gentisate aldehyde + Water
conversion direction: LEFT_TO_RIGHT

Reaction180223
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000084/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558/Stoichiometry/1.0
right: Homogentisic acid
right: Carbon dioxide
spontaneous: false
left: Oxygen
left: 4-Hydroxyphenylpyruvic acid
name: 4-Hydroxyphenylpyruvic acid + Oxygen → Carbon dioxide + Homogentisic acid
conversion direction: LEFT_TO_RIGHT

Reaction180222
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000558/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003007/Stoichiometry/1.0
right: 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
spontaneous: false
left: 4-Hydroxyphenylpyruvic acid
name: 4-Hydroxyphenylpyruvic acid ↔ 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
conversion direction: REVERSIBLE

Reaction180225
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001376/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000981/Stoichiometry/1.0
right: 4-Fumarylacetoacetic acid
spontaneous: false
left: Maleylacetoacetic acid
name: Maleylacetoacetic acid → 4-Fumarylacetoacetic acid
conversion direction: LEFT_TO_RIGHT

Reaction180224
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001376/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000084/Stoichiometry/1.0
right: Maleylacetoacetic acid
spontaneous: false
left: Homogentisic acid
left: Oxygen
name: Homogentisic acid + Oxygen → Maleylacetoacetic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/PubChem-compound 119219
type: UnificationXref
id: 119219
db: PubChem-compound

Reaction180221
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001966/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000013/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: p-Hydroxyphenylacetic acid
right: Hydrogen Ion
spontaneous: false
left: Water
left: NAD
left: 4-Hydroxyphenylacetaldehyde
name: 4-Hydroxyphenylacetaldehyde + NAD + Water ↔ Hydrogen Ion + NADH + p-Hydroxyphenylacetic acid
conversion direction: REVERSIBLE

Reaction180220
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001966 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000210 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: 4-Hydroxyphenylacetaldehyde
spontaneous: false
left: Water
left: Tyramine
left: Oxygen
name: Oxygen + Tyramine + Water → 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reaction180256
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002043 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002041 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040712 Mitochondrion/Stoichiometry/1.0
right: Hydrogen peroxide
right: 3-Methoxy-4-hydroxyphenylglycolaldehyde
right: Methylammonium
spontaneous: false
left: Water
left: Metanephrine
left: Oxygen
name: Metanephrine + Oxygen + Water → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylammonium
conversion direction: LEFT_TO_RIGHT

Reaction180255
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002043/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000048/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Metanephrine
spontaneous: false
left: Epinephrine
left: S-Adenosylmethionine
name: Epinephrine + S-Adenosylmethionine → Metanephrine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Normetanephrine
type: SmallMolecule
entity reference: Normetanephrine

Reaction180254
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000048/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Epinephrine
spontaneous: false
left: Norepinephrine
left: S-Adenosylmethionine
name: Norepinephrine + S-Adenosylmethionine → Epinephrine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Reaction180250
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002041/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000197/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Vanillylmandelic acid
spontaneous: false
left: Water
left: 3-Methoxy-4-hydroxyphenylglycolaldehyde
left: NAD
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde + NAD + Water → Hydrogen Ion + NADH + Vanillylmandelic acid
conversion direction: LEFT_TO_RIGHT

Reaction180249
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002041 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000654 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: 3-Methoxy-4-hydroxyphenylglycolaldehyde
spontaneous: false
left: Water
left: Normetanephrine
left: Oxygen
name: Normetanephrine + Oxygen + Water → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 388447
type: UnificationXref
id: 388447
db: ChemSpider

Reaction180248
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000654/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Normetanephrine
spontaneous: false
left: Norepinephrine
left: S-Adenosylmethionine
name: Norepinephrine + S-Adenosylmethionine → Normetanephrine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reaction180245
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001240/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: 3,4-Dihydroxymandelic acid
right: Hydrogen Ion
spontaneous: false
left: 3,4-Dihydroxymandelaldehyde
left: Water
left: NAD
name: 3,4-Dihydroxymandelaldehyde + NAD + Water ↔ 3,4-Dihydroxymandelic acid + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Reaction180244
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001147/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000222/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Vanylglycol
spontaneous: false
left: 3,4-Dihydroxyphenylglycol
left: S-Adenosylmethionine
name: 3,4-Dihydroxyphenylglycol + S-Adenosylmethionine → S-Adenosylhomocysteine + Vanylglycol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reaction180247
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001240/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000197/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Vanillylmandelic acid
spontaneous: false
left: 3,4-Dihydroxymandelic acid
left: S-Adenosylmethionine
name: 3,4-Dihydroxymandelic acid + S-Adenosylmethionine ↔ S-Adenosylhomocysteine + Vanillylmandelic acid
conversion direction: REVERSIBLE

Reference/CAS 17592-23-3
type: UnificationXref
id: 17592-23-3
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/KEGG Compound C00483
type: UnificationXref
id: C00483
db: KEGG Compound

ChemicalStructure/PW C001904
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@](N)(CC1=CC(I)=C(O)C(I)=C1)C(O)=O

4-Hydroxyphenylacetaldehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440113
xref: Reference/ChEBI CHEBI 15621
xref: Reference/CAS 7339-87-9
xref: Reference/HMDB HMDB0003767
xref: Reference/KEGG Compound C03765
xref: Reference/ChemSpider 389113
xref: Reference/BioCyc CPD-1041
chemical formula: C8H8O2
molecular weight: 136.05243
structure: ChemicalStructure/PW C001966

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChemSpider 82648
type: UnificationXref
id: 82648
db: ChemSpider

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Compound/PW C000117/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

3,4-Dihydroxyphenylacetaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04043
xref: Reference/ChemSpider 106504
xref: Reference/PubChem-compound 119219
xref: Reference/ChEBI CHEBI 27978
xref: Reference/CAS 5707-55-1
xref: Reference/HMDB HMDB0003791
chemical formula: C8H8O3
molecular weight: 152.04735
structure: ChemicalStructure/PW C001969

Compound/PW C001966/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

Reaction180241
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000052 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104792 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytoplasm/Stoichiometry/1.0
right: Norepinephrine
right: Water
right: Dehydroascorbate
spontaneous: false
left: Oxygen
left: Dopamine
left: Ascorbic acid
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbate + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Reaction180240
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000074/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001029/Stoichiometry/1.0
right: Homovanillic acid
right: S-Adenosylhomocysteine
spontaneous: false
left: S-Adenosylmethionine
left: 3,4-Dihydroxybenzeneacetic acid
name: 3,4-Dihydroxybenzeneacetic acid + S-Adenosylmethionine → Homovanillic acid + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

1.1.1.284
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000222 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytoplasm/Stoichiometry/1.0
right: 3,4-Dihydroxyphenylglycol
right: NAD
spontaneous: false
EC number: 1.1.1.284
left: Hydrogen Ion
left: NADH
left: 3,4-Dihydroxymandelaldehyde
name: 3,4-Dihydroxymandelaldehyde + Hydrogen Ion + NADH ↔ 3,4-Dihydroxyphenylglycol + NAD
conversion direction: REVERSIBLE

Reaction180242
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: 3,4-Dihydroxymandelaldehyde
right: Hydrogen peroxide
spontaneous: false
left: Water
left: Norepinephrine
left: Oxygen
name: Norepinephrine + Oxygen + Water → 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Compound/PW C002043 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Metanephrine
stoichiometric coefficient: 1.0

2-Aminoacrylic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 110510
xref: Reference/CAS 1948-56-7
xref: Reference/KEGG Compound C02218
xref: Reference/HMDB HMDB0003609
xref: Reference/PubChem-compound 123991
xref: Reference/ChEBI CHEBI 17123
chemical formula: C3H5NO2
molecular weight: 87.03203
structure: ChemicalStructure/PW C001938

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/BioCyc LIOTHYRONINE
type: UnificationXref
id: LIOTHYRONINE
db: BioCyc

3,4-Dihydroxyphenylacetaldehyde
type: SmallMolecule
entity reference: 3,4-Dihydroxyphenylacetaldehyde

Compound/PW C001783/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/BioCyc IODINE-MOLECULE
type: UnificationXref
id: IODINE-MOLECULE
db: BioCyc

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C03765
type: UnificationXref
id: C03765
db: KEGG Compound

4-Hydroxyphenylacetaldehyde
type: SmallMolecule
entity reference: 4-Hydroxyphenylacetaldehyde

Reference/HMDB HMDB0060291
type: UnificationXref
id: HMDB0060291
db: HMDB

Reference/UniProt Q0ZBR7
type: UnificationXref
id: Q0ZBR7
db: UniProt

L-Tyrosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Tyrosine

Reference/ChEBI CHEBI 17123
type: UnificationXref
id: CHEBI:17123
db: ChEBI

4-Hydroxyphenylacetaldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 4-Hydroxyphenylacetaldehyde

Oxygen
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxygen

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/UniProt Q6NSN2
type: UnificationXref
id: Q6NSN2
db: UniProt

Reference/UniProt Q7ZU10
type: UnificationXref
id: Q7ZU10
db: UniProt

Compound/PW C040071 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: I(-)
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Phenylalanine and Tyrosine Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110241
pathway component: SubPathwayInteraction110241
xref: Reference/PathWhiz PW122456
xref: Reference/SMPDB SMP0121168
name: SubPathway

Reference/UniProt Q504E5
type: UnificationXref
id: Q504E5
db: UniProt

Amine oxidase
type: Protein
cellular location: Mitochondrion
entity reference: Amine oxidase

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/ChemSpider 3350
type: UnificationXref
id: 3350
db: ChemSpider

Amine oxidase [flavin-containing]
type: ProteinReference
xref: Reference/UniProt Q6NSN2
organism: Danio rerio

Aldehyde dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q7ZU10
organism: Danio rerio

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Reference/KEGG Compound C17935
type: UnificationXref
id: C17935
db: KEGG Compound

Compound/PW C000103/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Compound/PW C000169 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thyroxine
stoichiometric coefficient: 1.0

Amine oxidase
type: ProteinReference
xref: Reference/UniProt F1QRA1
organism: Danio rerio

Reference/KEGG Compound C02218
type: UnificationXref
id: C02218
db: KEGG Compound

Aspartate aminotransferase
type: ProteinReference
xref: Reference/UniProt Q7ZWF5
organism: Danio rerio

Tat protein
type: ProteinReference
xref: Reference/UniProt A0JMN6
organism: Danio rerio

Glutathione S-transferase zeta 1
type: Protein
entity reference: Glutathione S-transferase zeta 1

Hgd protein
type: Protein
entity reference: Hgd protein

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Aldehyde oxidase 6
type: ProteinReference
xref: Reference/UniProt F1Q5R8
organism: Danio rerio

Macrophage migration inhibitory factor
type: Protein
entity reference: Macrophage migration inhibitory factor

Aldehyde oxidase 5
type: ProteinReference
xref: Reference/UniProt M1ZMM0
organism: Danio rerio

Reference/BioCyc 4-HYDROXYPHENYLACETATE
type: UnificationXref
id: 4-HYDROXYPHENYLACETATE
db: BioCyc

Reference/ChEBI CHEBI 17189
type: UnificationXref
id: CHEBI:17189
db: ChEBI

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Hydrogen peroxide
type: SmallMolecule
entity reference: Hydrogen peroxide

Reference/HMDB HMDB0006915
type: UnificationXref
id: HMDB0006915
db: HMDB

4-hydroxyphenylpyruvate dioxygenase
type: Protein
entity reference: 4-hydroxyphenylpyruvate dioxygenase

Tyramine
type: SmallMolecule
entity reference: Tyramine

Ddc protein
type: Protein
entity reference: Ddc protein

Reference/HMDB HMDB0001229
type: UnificationXref
id: HMDB0001229
db: HMDB

Pyruvate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110237
pathway component: SubPathwayInteraction110237
name: SubPathway

Citrate cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110238
pathway component: SubPathwayInteraction110238
name: SubPathway

Reference/CAS 19641-92-0
type: UnificationXref
id: 19641-92-0
db: CAS

Reference/HMDB HMDB0000130
type: UnificationXref
id: HMDB0000130
db: HMDB

Reference/SMPDB SMP0121221
type: UnificationXref
id: SMP0121221
db: SMPDB

ChemicalStructure/PW C001029
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CC(O)=C(O)C=C1

L-Cysteine
type: SmallMolecule
entity reference: L-Cysteine

Reference/KEGG Compound C02465
type: UnificationXref
id: C02465
db: KEGG Compound

Reference/KEGG Compound C01382
type: UnificationXref
id: C01382
db: KEGG Compound

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

ChemicalStructure/PW C000181
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChEBI CHEBI 18258
type: UnificationXref
id: CHEBI:18258
db: ChEBI

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Dopamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dopamine

Reference/PubChem-compound 547
type: UnificationXref
id: 547
db: PubChem-compound

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Reference/PubChem-compound 780
type: UnificationXref
id: 780
db: PubChem-compound

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

ChemicalStructure/PW C001240
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(O)=O)C1=CC=C(O)C(O)=C1

Reference/HMDB HMDB0000152
type: UnificationXref
id: HMDB0000152
db: HMDB

Reference/SMPDB SMP0121219
type: UnificationXref
id: SMP0121219
db: SMPDB

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Normetanephrine
type: SmallMoleculeReference
xref: Reference/CAS 97-31-4
xref: Reference/ChemSpider 1200
xref: Reference/PubChem-compound 1237
xref: Reference/ChEBI CHEBI 144308
xref: Reference/HMDB HMDB0000819
xref: Reference/KEGG Compound C05589
chemical formula: C9H13NO3
molecular weight: 183.08954
structure: ChemicalStructure/PW C000654

Compound/PW C001938 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminoacrylic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/PubChem-compound 21100
type: UnificationXref
id: 21100
db: PubChem-compound

ChemicalStructure/PW C000169
type: ChemicalStructure
structure format: SMILES

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C01161
type: UnificationXref
id: C01161
db: KEGG Compound

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Dehydroascorbate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dehydroascorbate

Reference/HMDB HMDB0001490
type: UnificationXref
id: HMDB0001490
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/CAS 5703-24-2
type: UnificationXref
id: 5703-24-2
db: CAS

3-Methoxytyramine
type: SmallMolecule
entity reference: 3-Methoxytyramine

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

L-Dopachrome
type: SmallMolecule
entity reference: L-Dopachrome
name: SubPathwayInput

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 306-08-1
type: UnificationXref
id: 306-08-1
db: CAS

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/PubChem-compound 1738
type: UnificationXref
id: 1738
db: PubChem-compound

ChemicalStructure/PW C003007
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(\O)=C\C1=CC=C(O)C=C1

Reference/HMDB HMDB0001268
type: UnificationXref
id: HMDB0001268
db: HMDB

p-Hydroxyphenylacetic acid
type: SmallMolecule
entity reference: p-Hydroxyphenylacetic acid

Norepinephrine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Norepinephrine

Homovanillin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 151276
xref: Reference/CAS 5703-24-2
xref: Reference/KEGG Compound C05581
xref: Reference/HMDB HMDB0005175
xref: Reference/ChEBI CHEBI 28111
xref: Reference/ChemSpider 133331
chemical formula: C9H10O3
molecular weight: 166.06299
structure: ChemicalStructure/PW C002411

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Reference/CAS 102-32-9
type: UnificationXref
id: 102-32-9
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Glutathione S-transferase zeta 1
type: ProteinReference
xref: Reference/UniProt Q6DGL3
organism: Danio rerio

4-hydroxyphenylpyruvate dioxygenase
type: ProteinReference
xref: Reference/UniProt Q7ZUY6
organism: Danio rerio

Reference/BioCyc IODO-L-TYROSINE
type: UnificationXref
id: IODO-L-TYROSINE
db: BioCyc

Macrophage migration inhibitory factor
type: ProteinReference
xref: Reference/UniProt Q0ZBR7
organism: Danio rerio

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Eosinophil peroxidase
type: ProteinReference
organism: Danio rerio

Hgd protein
type: ProteinReference
xref: Reference/UniProt Q6P2V4
organism: Danio rerio

Ddc protein
type: ProteinReference
xref: Reference/UniProt Q7SZR0
organism: Danio rerio

Amine oxidase
type: ProteinReference
xref: Reference/UniProt F1R2V0
organism: Danio rerio

Compound/PW C002683 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01179
type: UnificationXref
id: C01179
db: KEGG Compound

Reference/PubChem-compound 636708
type: UnificationXref
id: 636708
db: PubChem-compound

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Reference/ChEBI CHEBI 43451
type: UnificationXref
id: CHEBI:43451
db: ChEBI

Compound/PW C000015/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxytyramine
stoichiometric coefficient: 1.0

Reference/CAS 156-39-8
type: UnificationXref
id: 156-39-8
db: CAS

Acetoacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetoacetic acid

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Uncharacterized protein
type: ProteinReference
organism: Danio rerio

2-Aminoacrylic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2-Aminoacrylic acid

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Tyr protein
type: ProteinReference
xref: Reference/UniProt Q504L5
organism: Danio rerio

Reference/ChemSpider 133725
type: UnificationXref
id: 133725
db: ChemSpider

Catechol O-methyltransferase A
type: ProteinReference
xref: Reference/UniProt F4ZGF2
organism: Danio rerio

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt B3DGL8
organism: Danio rerio

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

S-(hydroxymethyl)glutathione dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q6NXA6
organism: Danio rerio

Compound/PW C000532 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodine
stoichiometric coefficient: 1.0

Reference/BioCyc DIIODO-L-TYROSINE
type: UnificationXref
id: DIIODO-L-TYROSINE
db: BioCyc

Fumarylacetoacetase
type: ProteinReference
xref: Reference/UniProt Q803S0
organism: Danio rerio

Zgc:109929
type: ProteinReference
xref: Reference/UniProt Q504E5
organism: Danio rerio

Aldehyde oxidase 5
type: Protein
cellular location: Cytosol
entity reference: Aldehyde oxidase 5

Compound/PW C001147/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vanylglycol
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000197
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(=C1)[C@H](O)C(O)=O

Homovanillin
type: SmallMolecule
entity reference: Homovanillin

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Tyramine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5408
xref: Reference/CAS 51-67-2
xref: Reference/BioCyc CPD-7650
xref: Reference/HMDB HMDB0000306
xref: Reference/KEGG Compound C00483
xref: Reference/PubChem-compound 5610
xref: Reference/ChEBI CHEBI 15760
chemical formula: C8H11NO
molecular weight: 137.08406
structure: ChemicalStructure/PW C000210

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/ChemSpider 5707
type: UnificationXref
id: 5707
db: ChemSpider

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/UniProt Q6DGL3
type: UnificationXref
id: Q6DGL3
db: UniProt

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

ReactionCatalysis169611
type: Catalysis
controller: Tat protein
controlled: Reaction179729
control type: ACTIVATION

ReactionCatalysis169610
type: Catalysis
controller: Aspartate aminotransferase
controlled: Reaction179729
control type: ACTIVATION

Aldehyde oxidase
type: Complex
cellular location: Cytosol
component: Aldehyde oxidase 5
component: Aldehyde oxidase 6

Reference/PathWhiz PW122456
type: UnificationXref
id: PW122456
db: PathWhiz

Reference/ChemSpider 110510
type: UnificationXref
id: 110510
db: ChemSpider

3,4-Dihydroxyphenylglycol
type: SmallMolecule
entity reference: 3,4-Dihydroxyphenylglycol

Reference/CAS 55-10-7
type: UnificationXref
id: 55-10-7
db: CAS

Compound/PW C000088/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

3,4-Dihydroxyphenylglycol
type: SmallMoleculeReference
xref: Reference/CAS 3343-19-9
xref: Reference/ChEBI CHEBI 1387
xref: Reference/HMDB HMDB0000318
xref: Reference/KEGG Compound C05576
xref: Reference/ChemSpider 82648
xref: Reference/PubChem-compound 91528
chemical formula: C8H10O4
molecular weight: 170.0579
structure: ChemicalStructure/PW C000222

Reference/PubChem-compound 979
type: UnificationXref
id: 979
db: PubChem-compound

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Compound/PW C000048/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003474
type: UnificationXref
id: HMDB0003474
db: HMDB

ReactionCatalysis169609
type: Catalysis
controller: Amine oxidase
controlled: Reaction179728
control type: ACTIVATION

Reference/ChemSpider 19844
type: UnificationXref
id: 19844
db: ChemSpider

Reference/PubChem-compound 127
type: UnificationXref
id: 127
db: PubChem-compound

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Vanylglycol
type: SmallMolecule
entity reference: Vanylglycol

Reference/PubChem-compound 91528
type: UnificationXref
id: 91528
db: PubChem-compound

Reference/PubChem-compound 25201348
type: UnificationXref
id: 25201348
db: PubChem-compound

NADH
type: SmallMolecule
entity reference: NADH

Dopamine
type: SmallMolecule
entity reference: Dopamine

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

Aldehyde oxidase 6
type: Protein
cellular location: Cytosol
entity reference: Aldehyde oxidase 6

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

ChemicalStructure/PW C000210
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC=C(O)C=C1

Reference/ChEBI CHEBI 27956
type: UnificationXref
id: CHEBI:27956
db: ChEBI

Reference/HMDB HMDB0001866
type: UnificationXref
id: HMDB0001866
db: HMDB

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

ChemicalStructure/PW C104789
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(=O)CC(=O)C(O)=O

Gentisate aldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Gentisate aldehyde

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Tyramine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Tyramine

Epinephrine
type: SmallMolecule
entity reference: Epinephrine

Reference/KEGG Compound C05576
type: UnificationXref
id: C05576
db: KEGG Compound

Reference/PubChem-compound 96024156
type: UnificationXref
id: 96024156
db: PubChem-compound

Reference/KEGG Compound C05577
type: UnificationXref
id: C05577
db: KEGG Compound

Reference/KEGG Compound C05583
type: UnificationXref
id: C05583
db: KEGG Compound

Reference/KEGG Compound C05582
type: UnificationXref
id: C05582
db: KEGG Compound

Ammonia
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Ammonia

Maleylacetoacetic acid
type: SmallMolecule
entity reference: Maleylacetoacetic acid

Reference/KEGG Compound C05585
type: UnificationXref
id: C05585
db: KEGG Compound

3,4-Dihydroxyphenylacetaldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3,4-Dihydroxyphenylacetaldehyde

Reference/KEGG Compound C05584
type: UnificationXref
id: C05584
db: KEGG Compound

Reference/CAS 7339-87-9
type: UnificationXref
id: 7339-87-9
db: CAS

ChemicalStructure/PW C104791
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Maleylacetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 47904
xref: Reference/ChemSpider 4444078
xref: Reference/CAS 5698-52-2
xref: Reference/HMDB HMDB0002052
xref: Reference/PubChem-compound 5280393
xref: Reference/KEGG Compound C01036
xref: Reference/BioCyc 4-MALEYL-ACETOACETATE
chemical formula: C8H8O6
molecular weight: 200.03209
structure: ChemicalStructure/PW C001376

Reference/ChemSpider 64111
type: UnificationXref
id: 64111
db: ChemSpider

Reference/KEGG Compound C05581
type: UnificationXref
id: C05581
db: KEGG Compound

ChemicalStructure/PW C000222
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C1=CC(O)=C(O)C=C1

ChemicalStructure/PW C104792
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@@H](O)CO

Reference/KEGG Compound C05580
type: UnificationXref
id: C05580
db: KEGG Compound

Reference/ChemSpider 388804
type: UnificationXref
id: 388804
db: ChemSpider

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Tat protein
type: Protein
cellular location: Mitochondrion
entity reference: Tat protein

Reference/PubChem-compound 440729
type: UnificationXref
id: 440729
db: PubChem-compound

Reference/HMDB HMDB0000306
type: UnificationXref
id: HMDB0000306
db: HMDB

Norepinephrine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Norepinephrine

Reference/KEGG Compound C05587
type: UnificationXref
id: C05587
db: KEGG Compound

Reference/KEGG Compound C05589
type: UnificationXref
id: C05589
db: KEGG Compound

Reference/KEGG Compound C05588
type: UnificationXref
id: C05588
db: KEGG Compound

Reference/KEGG Compound C05594
type: UnificationXref
id: C05594
db: KEGG Compound

Compound/PW C001904 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,5-Diiodo-L-tyrosine
stoichiometric coefficient: 1.0

ReactionCatalysis170066
type: Catalysis
controller: Eosinophil peroxidase
controlled: Reaction180213
control type: ACTIVATION

I(-)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: I(-)

Reference/KEGG Compound C05590
type: UnificationXref
id: C05590
db: KEGG Compound

Ammonia
type: SmallMolecule
entity reference: Ammonia

ReactionCatalysis170067
type: Catalysis
controller: Eosinophil peroxidase
controlled: Reaction180214
control type: ACTIVATION

Reference/KEGG Compound C05350
type: UnificationXref
id: C05350
db: KEGG Compound

ReactionCatalysis170069
type: Catalysis
controller: Eosinophil peroxidase
controlled: Reaction180216
control type: ACTIVATION

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Iodotyrosine
type: SmallMoleculeReference
xref: Reference/CAS 70-78-0
xref: Reference/KEGG Compound C02515
xref: Reference/BioCyc IODO-L-TYROSINE
xref: Reference/ChEBI CHEBI 27847
xref: Reference/ChemSpider 388804
xref: Reference/PubChem-compound 439744
xref: Reference/HMDB HMDB0000021
chemical formula: C9H10INO3
molecular weight: 306.97055
structure: ChemicalStructure/PW C000014

Compound/PW C002041/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxy-4-hydroxyphenylglycolaldehyde
stoichiometric coefficient: 1.0

p-Hydroxyphenylacetic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 127
xref: Reference/ChemSpider 124
xref: Reference/CAS 156-38-7
xref: Reference/HMDB HMDB0000020
xref: Reference/BioCyc 4-HYDROXYPHENYLACETATE
xref: Reference/KEGG Compound C00642
xref: Reference/ChEBI CHEBI 18101
chemical formula: C8H8O3
molecular weight: 152.04735
structure: ChemicalStructure/PW C000013

Compound/PW C000088 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

3-Methoxytyramine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 742324
xref: Reference/PubChem-compound 1669
xref: Reference/CAS 554-52-9
xref: Reference/KEGG Compound C05587
xref: Reference/HMDB HMDB0000022
xref: Reference/ChemSpider 1606
chemical formula: C9H13NO2
molecular weight: 167.09464
structure: ChemicalStructure/PW C000015

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Reference/HMDB HMDB0000318
type: UnificationXref
id: HMDB0000318
db: HMDB

L-Dopachrome
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15772
xref: Reference/CAS 89762-39-0
xref: Reference/PubChem-compound 5459802
xref: Reference/ChemSpider 4573572
xref: Reference/KEGG Compound C01693
xref: Reference/HMDB HMDB0001430
chemical formula: C9H7NO4
molecular weight: 193.0375
structure: ChemicalStructure/PW C001105

ReactionCatalysis170075
type: Catalysis
controller: Aldehyde dehydrogenase
controlled: Reaction180221
control type: ACTIVATION

3,4-Dihydroxyphenylglycol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3,4-Dihydroxyphenylglycol

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
entity reference: 3,4-Dihydroxymandelaldehyde

ReactionCatalysis170074
type: Catalysis
controller: Amine oxidase [flavin-containing]
controlled: Reaction180220
control type: ACTIVATION

Reference/CAS 1948-56-7
type: UnificationXref
id: 1948-56-7
db: CAS

ReactionCatalysis170077
type: Catalysis
controller: 4-hydroxyphenylpyruvate dioxygenase
controlled: Reaction180223
control type: ACTIVATION

ReactionCatalysis170076
type: Catalysis
controller: Macrophage migration inhibitory factor
controlled: Reaction180222
control type: ACTIVATION

3,4-Dihydroxymandelaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27852
xref: Reference/PubChem-compound 151725
xref: Reference/ChemSpider 133725
xref: Reference/CAS 13023-73-9
xref: Reference/HMDB HMDB0006242
xref: Reference/KEGG Compound C05577
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C002683

ReactionCatalysis170079
type: Catalysis
controller: Glutathione S-transferase zeta 1
controlled: Reaction180225
control type: ACTIVATION

ReactionCatalysis170078
type: Catalysis
controller: Hgd protein
controlled: Reaction180224
control type: ACTIVATION

Reference/CAS 18766-67-1
type: UnificationXref
id: 18766-67-1
db: CAS

ReactionCatalysis170071
type: Catalysis
controller: Eosinophil peroxidase
controlled: Reaction180218
control type: ACTIVATION

ReactionCatalysis170073
type: Catalysis
controller: Amine oxidase
controlled: Reaction180220
control type: ACTIVATION

ReactionCatalysis170072
type: Catalysis
controller: Ddc protein
controlled: Reaction180219
control type: ACTIVATION

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/ChEBI CHEBI 16852
type: UnificationXref
id: CHEBI:16852
db: ChEBI

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Fumaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Fumaric acid

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Reference/ChEBI CHEBI 15768
type: UnificationXref
id: CHEBI:15768
db: ChEBI

SubPathwayInteraction110238
type: Interaction
name: SubPathwayReaction
name: SubPathway110238Reaction
participant: Fumaric acid

SubPathwayInteraction110237
type: Interaction
name: SubPathway110237Reaction
name: SubPathwayReaction
participant: Pyruvic acid

Compound/PW C002043/Stoichiometry/1.0
type: Stoichiometry
physical entity: Metanephrine
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChEBI CHEBI 15760
type: UnificationXref
id: CHEBI:15760
db: ChEBI

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Compound/PW C001029/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxybenzeneacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

ReactionCatalysis170086
type: Catalysis
controller: Ddc protein
controlled: Reaction180234
control type: ACTIVATION

Reference/KEGG Compound C04043
type: UnificationXref
id: C04043
db: KEGG Compound

ReactionCatalysis170085
type: Catalysis
controller: Tyr protein
controlled: Reaction180232
control type: ACTIVATION

ReactionCatalysis170088
type: Catalysis
controller: Amine oxidase [flavin-containing]
controlled: Reaction180235
control type: ACTIVATION

ReactionCatalysis170087
type: Catalysis
controller: Amine oxidase
controlled: Reaction180235
control type: ACTIVATION

ChemicalStructure/PW C000015
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CCN)=C1

ChemicalStructure/PW C000014
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(I)=C1)C(O)=O

ReactionCatalysis170089
type: Catalysis
controller: Catechol O-methyltransferase A
controlled: 2.1.1.6
control type: ACTIVATION

ChemicalStructure/PW C000013
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CC=C(O)C=C1

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

ReactionCatalysis170080
type: Catalysis
controller: Fumarylacetoacetase
controlled: 3.7.1.2
control type: ACTIVATION

ReactionCatalysis170082
type: Catalysis
controller: Unknown
controlled: Reaction180228
control type: ACTIVATION

Compound/PW C002044/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leucodopachrome
stoichiometric coefficient: 1.0

ReactionCatalysis170081
type: Catalysis
controller: Zgc:109929
controlled: Reaction180227
control type: ACTIVATION

ReactionCatalysis170084
type: Catalysis
controller: Tyr protein
controlled: Reaction180230
control type: ACTIVATION

Homovanillic acid
type: SmallMoleculeReference
xref: Reference/CAS 306-08-1
xref: Reference/KEGG Compound C05582
xref: Reference/PubChem-compound 1738
xref: Reference/HMDB HMDB0000118
xref: Reference/ChemSpider 1675
xref: Reference/ChEBI CHEBI 545959
chemical formula: C9H10O4
molecular weight: 182.0579
structure: ChemicalStructure/PW C000074

ReactionCatalysis170083
type: Catalysis
controller: Aldehyde oxidase
controlled: Reaction180229
control type: ACTIVATION

Reference/ChEBI CHEBI 15772
type: UnificationXref
id: CHEBI:15772
db: ChEBI

Reference/ChEBI CHEBI 144308
type: UnificationXref
id: CHEBI:144308
db: ChEBI

Reference/HMDB HMDB0003609
type: UnificationXref
id: HMDB0003609
db: HMDB

Reference/PubChem-compound 5920
type: UnificationXref
id: 5920
db: PubChem-compound

ChemicalStructure/PW C001105
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CC2=CC(=O)C(=O)C=C2N1

Reference/PubChem-compound 161255
type: UnificationXref
id: 161255
db: PubChem-compound

ReactionCatalysis170097
type: Catalysis
controller: Catechol O-methyltransferase A
controlled: Reaction180244
control type: ACTIVATION

ReactionCatalysis170096
type: Catalysis
controller: S-(hydroxymethyl)glutathione dehydrogenase
controlled: 1.1.1.284
control type: ACTIVATION

Homogentisic acid
type: SmallMolecule
entity reference: Homogentisic acid

ReactionCatalysis170098
type: Catalysis
controller: Aldehyde dehydrogenase
controlled: Reaction180245
control type: ACTIVATION

Fumaric acid
type: SmallMolecule
entity reference: Fumaric acid
name: SubPathwayInput

ChemicalStructure/PW C002683
type: ChemicalStructure
structure format: SMILES
structure data: OC(C=O)C1=CC(O)=C(O)C=C1

ReactionCatalysis170091
type: Catalysis
controller: Aldehyde dehydrogenase
controlled: Reaction180238
control type: ACTIVATION

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

ReactionCatalysis170090
type: Catalysis
controller: Amine oxidase [flavin-containing]
controlled: Reaction180237
control type: ACTIVATION

ReactionCatalysis170093
type: Catalysis
controller: Catechol O-methyltransferase A
controlled: Reaction180240
control type: ACTIVATION

Reference/PubChem-compound 439744
type: UnificationXref
id: 439744
db: PubChem-compound

ReactionCatalysis170092
type: Catalysis
controller: Aldehyde dehydrogenase
controlled: Reaction180239
control type: ACTIVATION

Reference/ChEBI CHEBI 30907
type: UnificationXref
id: CHEBI:30907
db: ChEBI

Reference/HMDB HMDB0001430
type: UnificationXref
id: HMDB0001430
db: HMDB

ReactionCatalysis170095
type: Catalysis
controller: Amine oxidase [flavin-containing]
controlled: Reaction180242
control type: ACTIVATION

Homogentisic acid
type: SmallMoleculeReference
xref: Reference/CAS 451-13-8
xref: Reference/ChEBI CHEBI 44747
xref: Reference/ChemSpider 759
xref: Reference/HMDB HMDB0000130
xref: Reference/KEGG Compound C00544
xref: Reference/PubChem-compound 780
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C000084

ReactionCatalysis170094
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: Reaction180241
control type: ACTIVATION

Compound/PW C002411/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16830
type: UnificationXref
id: CHEBI:16830
db: ChEBI

Epinephrine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000068
xref: Reference/KEGG Compound C00788
xref: Reference/PubChem-compound 5816
xref: Reference/ChemSpider 5611
xref: Reference/CAS 51-43-4
xref: Reference/BioCyc L-EPINEPHRINE
xref: Reference/ChEBI CHEBI 28918
chemical formula: C9H13NO3
molecular weight: 183.08954
structure: ChemicalStructure/PW C000048

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

3-Methoxytyramine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3-Methoxytyramine

Methylammonium
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Methylammonium

ChemicalStructure/PW C002411
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(CC=O)=C1

Homovanillic acid
type: SmallMolecule
entity reference: Homovanillic acid

Reference/CAS 300-39-0 66-02-4
type: UnificationXref
id: 300-39-0 66-02-4
db: CAS

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/HMDB HMDB0000118
type: UnificationXref
id: HMDB0000118
db: HMDB

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27978
type: UnificationXref
id: CHEBI:27978
db: ChEBI

Reference/ChEBI CHEBI 1387
type: UnificationXref
id: CHEBI:1387
db: ChEBI

Vanylglycol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05594
xref: Reference/ChemSpider 10348
xref: Reference/CAS 534-82-7
xref: Reference/ChEBI CHEBI 846276
xref: Reference/PubChem-compound 10805
xref: Reference/HMDB HMDB0001490
chemical formula: C9H12O4
molecular weight: 184.07356
structure: ChemicalStructure/PW C001147

Reaction179729
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000558 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000103 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrion/Stoichiometry/1.0
right: 4-Hydroxyphenylpyruvic acid
right: L-Glutamic acid
spontaneous: false
left: Oxoglutaric acid
left: L-Tyrosine
name: L-Tyrosine + Oxoglutaric acid ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamic acid
conversion direction: REVERSIBLE

Reaction179728
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000103/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: Hydrogen peroxide
right: Ammonia
right: 4-Hydroxyphenylpyruvic acid
spontaneous: false
left: Water
left: Oxygen
left: L-Tyrosine
name: L-Tyrosine + Oxygen + Water → 4-Hydroxyphenylpyruvic acid + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Compound/PW C000181 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Liothyronine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15999
type: UnificationXref
id: CHEBI:15999
db: ChEBI

Methylammonium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00218
xref: Reference/ChEBI CHEBI 16830
xref: Reference/CAS 74-89-5
xref: Reference/PubChem-compound 6329
xref: Reference/HMDB HMDB0060291
xref: Reference/ChemSpider 6089
chemical formula: CH5N
molecular weight: 31.0422
structure: ChemicalStructure/PW C040712

Reference/HMDB HMDB0059634
type: UnificationXref
id: HMDB0059634
db: HMDB

Compound/PW C000654/Stoichiometry/1.0
type: Stoichiometry
physical entity: Normetanephrine
stoichiometric coefficient: 1.0

SubPathwayInteraction110245
type: Interaction
name: SubPathway110245Reaction
name: SubPathwayReaction
participant: L-Dopachrome

SubPathwayInteraction110241
type: Interaction
name: SubPathway110241Reaction
name: SubPathwayReaction
participant: L-Tyrosine

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/UniProt Q6P2V4
type: UnificationXref
id: Q6P2V4
db: UniProt

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000981/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Fumarylacetoacetic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 133331
type: UnificationXref
id: 133331
db: ChemSpider

ChemicalStructure/PW C001938
type: ChemicalStructure
structure format: SMILES
structure data: NC(=C)C(O)=O

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

Compound/PW C000014 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iodotyrosine
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/PubChem-compound 10805
type: UnificationXref
id: 10805
db: PubChem-compound

ChemicalStructure/PW C040071
type: ChemicalStructure
structure format: SMILES
structure data: I

Reference/PubChem-compound 439316
type: UnificationXref
id: 439316
db: PubChem-compound

Reference/HMDB HMDB0004062
type: UnificationXref
id: HMDB0004062
db: HMDB

Reference/ChemSpider 8946
type: UnificationXref
id: 8946
db: ChemSpider

Reference/HMDB HMDB0004061
type: UnificationXref
id: HMDB0004061
db: HMDB

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Compound/PW C000134 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Reference/CAS 3343-19-9
type: UnificationXref
id: 3343-19-9
db: CAS

Reference/HMDB HMDB0004063
type: UnificationXref
id: HMDB0004063
db: HMDB

Reference/HMDB HMDB0006242
type: UnificationXref
id: HMDB0006242
db: HMDB

Reference/HMDB HMDB0004067
type: UnificationXref
id: HMDB0004067
db: HMDB

Reference/HMDB HMDB0000707
type: UnificationXref
id: HMDB0000707
db: HMDB

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/KEGG Compound C01829
type: UnificationXref
id: C01829
db: KEGG Compound

Gentisic acid
type: SmallMoleculeReference
xref: Reference/CAS 490-79-9
xref: Reference/KEGG Compound C00628
xref: Reference/PubChem-compound 3469
xref: Reference/HMDB HMDB0000152
xref: Reference/ChEBI CHEBI 17189
xref: Reference/ChemSpider 3350
chemical formula: C7H6O4
molecular weight: 154.02661
structure: ChemicalStructure/PW C000099

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Compound/PW C000142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Gentisate aldehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 70949
xref: Reference/KEGG Compound C05585
xref: Reference/HMDB HMDB0004062
xref: Reference/ChemSpider 64111
xref: Reference/ChEBI CHEBI 28508
xref: Reference/CAS 1194-98-5
chemical formula: C7H6O3
molecular weight: 138.0317
structure: ChemicalStructure/PW C002042

Metanephrine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 144365
xref: Reference/PubChem-compound 21100
xref: Reference/HMDB HMDB0004063
xref: Reference/CAS 5001-33-2
xref: Reference/KEGG Compound C05588
xref: Reference/ChemSpider 19844
chemical formula: C10H15NO3
molecular weight: 197.1052
structure: ChemicalStructure/PW C002043

Leucodopachrome
type: SmallMoleculeReference
xref: Reference/CAS 18766-67-1
xref: Reference/KEGG Compound C05604
xref: Reference/ChemSpider 141655
xref: Reference/PubChem-compound 161255
xref: Reference/ChEBI CHEBI 60872
xref: Reference/HMDB HMDB0004067
chemical formula: C9H9NO4
molecular weight: 195.05316
structure: ChemicalStructure/PW C002044

Reference/UniProt A0JMN6
type: UnificationXref
id: A0JMN6
db: UniProt

Compound/PW C000981 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Fumarylacetoacetic acid
stoichiometric coefficient: 1.0

3-Methoxy-4-hydroxyphenylglycolaldehyde
type: SmallMolecule
entity reference: 3-Methoxy-4-hydroxyphenylglycolaldehyde

Gentisate aldehyde
type: SmallMolecule
entity reference: Gentisate aldehyde

Reference/UniProt B3DGL8
type: UnificationXref
id: B3DGL8
db: UniProt

Metanephrine
type: SmallMolecule
entity reference: Metanephrine

Leucodopachrome
type: SmallMolecule
entity reference: Leucodopachrome

Reference/HMDB HMDB0005175
type: UnificationXref
id: HMDB0005175
db: HMDB

Unknown
type: Protein
entity reference: Unknown

3-Methoxy-4-hydroxyphenylglycolaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05583
xref: Reference/ChemSpider 389601
xref: Reference/HMDB HMDB0004061
xref: Reference/PubChem-compound 440729
xref: Reference/CAS 17592-23-3
chemical formula: C9H10O4
molecular weight: 182.0579
structure: ChemicalStructure/PW C002041

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Tyrosine

Compound/PW C104789/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Fumarylpyruvate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/PubChem-compound 5524
type: UnificationXref
id: 5524
db: PubChem-compound

ChemicalStructure/PW C000654
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(=CC=C1O)C(O)CN

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/CAS 97-31-4
type: UnificationXref
id: 97-31-4
db: CAS

Compound/PW C002042/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gentisate aldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChemSpider 10348
type: UnificationXref
id: 10348
db: ChemSpider

Compound/PW C001966 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

Reference/CAS 51-48-9
type: UnificationXref
id: 51-48-9
db: CAS

Reference/ChEBI CHEBI 144365
type: UnificationXref
id: CHEBI:144365
db: ChEBI

Compound/PW C000749/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/KEGG Compound C00788
type: UnificationXref
id: C00788
db: KEGG Compound

Reference/CAS 5698-52-2
type: UnificationXref
id: 5698-52-2
db: CAS

ChemicalStructure/PW C001966
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(CC=O)C=C1

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/KEGG Compound C00544
type: UnificationXref
id: C00544
db: KEGG Compound

ChemicalStructure/PW C001969
type: ChemicalStructure
structure format: SMILES
structure data: OC1=C(O)C=C(CC=O)C=C1

Compound/PW C000015 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxytyramine
stoichiometric coefficient: 1.0

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

Reference/PubChem-compound 440113
type: UnificationXref
id: 440113
db: PubChem-compound

Gentisic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Gentisic acid

Reference/UniProt Q7ZUY6
type: UnificationXref
id: Q7ZUY6
db: UniProt

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/BioCyc L-THYROXINE
type: UnificationXref
id: L-THYROXINE
db: BioCyc

Compound/PW C000103 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/PubChem-compound 807
type: UnificationXref
id: 807
db: PubChem-compound

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Dopaquinone
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00822
xref: Reference/ChemSpider 388447
xref: Reference/CAS 4430-97-1 25520-73-4
xref: Reference/ChEBI CHEBI 16852
xref: Reference/HMDB HMDB0001229
xref: Reference/BioCyc DOPAQUINONE
xref: Reference/PubChem-compound 439316
chemical formula: C9H9NO4
molecular weight: 195.05316
structure: ChemicalStructure/PW C000952

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Iodine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Iodine

NAD
type: SmallMolecule
entity reference: NAD

Reference/CAS 554-52-9
type: UnificationXref
id: 554-52-9
db: CAS

Compound/PW C000103 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Compound/PW C000103/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 2.0

4-Fumarylacetoacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Fumarylacetoacetic acid

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Reference/ChEBI CHEBI 28111
type: UnificationXref
id: CHEBI:28111
db: ChEBI

Compound/PW C000035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Iodotyrosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Iodotyrosine

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/KEGG Compound C02514
type: UnificationXref
id: C02514
db: KEGG Compound

Reference/CAS 534-82-7
type: UnificationXref
id: 534-82-7
db: CAS

Reference/KEGG Compound C02515
type: UnificationXref
id: C02515
db: KEGG Compound

Dopaquinone
type: SmallMolecule
entity reference: Dopaquinone

Reference/ChemSpider 954
type: UnificationXref
id: 954
db: ChemSpider

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Unknown
type: ProteinReference
organism: Danio rerio

Reference/HMDB HMDB0002052
type: UnificationXref
id: HMDB0002052
db: HMDB

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Reference/ChEBI CHEBI 47904
type: UnificationXref
id: CHEBI:47904
db: ChEBI

Reference/ChemSpider 5611
type: UnificationXref
id: 5611
db: ChemSpider

Reference/ChemSpider 5614
type: UnificationXref
id: 5614
db: ChemSpider

Reference/SMPDB SMP0121168
type: UnificationXref
id: SMP0121168
db: SMPDB

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Homovanillin
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Homovanillin

Reference/UniProt Q803S0
type: UnificationXref
id: Q803S0
db: UniProt

Compound/PW C002683 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/ChemSpider 5408
type: UnificationXref
id: 5408
db: ChemSpider

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Compound/PW C000052 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/CAS 451-13-8
type: UnificationXref
id: 451-13-8
db: CAS

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/BioCyc DOPAQUINONE
type: UnificationXref
id: DOPAQUINONE
db: BioCyc

Reference/KEGG Compound C01693
type: UnificationXref
id: C01693
db: KEGG Compound

Reference/PubChem-compound 7786
type: UnificationXref
id: 7786
db: PubChem-compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/PathWhiz PW122513
type: UnificationXref
id: PW122513
db: PathWhiz

Reference/UniProt F1Q5R8
type: UnificationXref
id: F1Q5R8
db: UniProt

Reference/PubChem-compound 85782
type: UnificationXref
id: 85782
db: PubChem-compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChEBI CHEBI 18332
type: UnificationXref
id: CHEBI:18332
db: ChEBI

Reference/CAS 70-78-0
type: UnificationXref
id: 70-78-0
db: CAS

Reference/UniProt F4ZGF2
type: UnificationXref
id: F4ZGF2
db: UniProt

S-(hydroxymethyl)glutathione dehydrogenase
type: Protein
cellular location: Cytoplasm
entity reference: S-(hydroxymethyl)glutathione dehydrogenase

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C000210/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyramine
stoichiometric coefficient: 1.0

Reference/ChemSpider 552441
type: UnificationXref
id: 552441
db: ChemSpider

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMolecule
entity reference: S-Adenosylhomocysteine

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Reference/ChEBI CHEBI 18101
type: UnificationXref
id: CHEBI:18101
db: ChEBI

Compound/PW C001105/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopachrome
stoichiometric coefficient: 1.0

4-Fumarylacetoacetic acid
type: SmallMolecule
entity reference: 4-Fumarylacetoacetic acid

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

4-Fumarylacetoacetic acid
type: SmallMoleculeReference
xref: Reference/BioCyc 4-FUMARYL-ACETOACETATE
xref: Reference/HMDB HMDB0001268
xref: Reference/PubChem-compound 5280398
xref: Reference/KEGG Compound C01061
xref: Reference/ChemSpider 4444081
xref: Reference/ChEBI CHEBI 30907
xref: Reference/CAS 28613-33-4
chemical formula: C8H8O6
molecular weight: 200.03209
structure: ChemicalStructure/PW C000981

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChemSpider 389601
type: UnificationXref
id: 389601
db: ChemSpider

3-Fumarylpyruvate
type: SmallMolecule
entity reference: 3-Fumarylpyruvate

Reference/KEGG Compound C05604
type: UnificationXref
id: C05604
db: KEGG Compound

Reference/ChemSpider 141655
type: UnificationXref
id: 141655
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Water
type: SmallMolecule
entity reference: Water

Reference/ChemSpider 532
type: UnificationXref
id: 532
db: ChemSpider

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

ChemicalStructure/PW C001147
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(=CC=C1O)C(O)CO

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/HMDB HMDB0003767
type: UnificationXref
id: HMDB0003767
db: HMDB

4-Hydroxyphenylpyruvic acid
type: SmallMoleculeReference
xref: Reference/BioCyc P-HYDROXY-PHENYLPYRUVATE
xref: Reference/CAS 156-39-8
xref: Reference/ChEBI CHEBI 15999
xref: Reference/PubChem-compound 979
xref: Reference/HMDB HMDB0000707
xref: Reference/ChemSpider 954
xref: Reference/KEGG Compound C01179
chemical formula: C9H8O4
molecular weight: 180.04225
structure: ChemicalStructure/PW C000558

Reference/UniProt F1R2V0
type: UnificationXref
id: F1R2V0
db: UniProt

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/ChemSpider 6089
type: UnificationXref
id: 6089
db: ChemSpider

Reference/BioCyc CPD-1041
type: UnificationXref
id: CPD-1041
db: BioCyc

Reference/HMDB HMDB0000265
type: UnificationXref
id: HMDB0000265
db: HMDB

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000020
type: UnificationXref
id: HMDB0000020
db: HMDB

Reference/HMDB HMDB0000022
type: UnificationXref
id: HMDB0000022
db: HMDB

Reference/HMDB HMDB0000021
type: UnificationXref
id: HMDB0000021
db: HMDB

Reference/PubChem-compound 21844680
type: UnificationXref
id: 21844680
db: PubChem-compound

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxoglutaric acid

Dopamine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dopamine

Compound/PW C000197/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vanillylmandelic acid
stoichiometric coefficient: 1.0

Compound/PW C000142 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/PathWhiz PW122515
type: UnificationXref
id: PW122515
db: PathWhiz

4-Hydroxyphenylpyruvic acid
type: SmallMolecule
entity reference: 4-Hydroxyphenylpyruvic acid

Compound/PW C000031 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/CAS 13023-73-9
type: UnificationXref
id: 13023-73-9
db: CAS

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Reference/PubChem-compound 151276
type: UnificationXref
id: 151276
db: PubChem-compound

Compound/PW C000952/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopaquinone
stoichiometric coefficient: 1.0

Iodine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000675
xref: Reference/ChemSpider 785
xref: Reference/CAS 7553-56-2
xref: Reference/KEGG Compound C01382
xref: Reference/BioCyc IODINE-MOLECULE
xref: Reference/ChEBI CHEBI 17606
xref: Reference/PubChem-compound 807
chemical formula: I2
molecular weight: 253.80893
structure: ChemicalStructure/PW C000532

Reference/ChemSpider 4444081
type: UnificationXref
id: 4444081
db: ChemSpider

Reference/KEGG Compound C01036
type: UnificationXref
id: C01036
db: KEGG Compound

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/ChemSpider 785
type: UnificationXref
id: 785
db: ChemSpider

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

ChemicalStructure/PW C000048
type: ChemicalStructure
structure format: SMILES
structure data: CNC[C@H](O)C1=CC(O)=C(O)C=C1

Cysteinyldopa
type: SmallMolecule
entity reference: Cysteinyldopa

ChemicalStructure/PW C001376
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)CC(=O)\C=C/C(O)=O

Reference/PubChem-compound 1669
type: UnificationXref
id: 1669
db: PubChem-compound

Compound/PW C002041 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methoxy-4-hydroxyphenylglycolaldehyde
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003791
type: UnificationXref
id: HMDB0003791
db: HMDB

Compound/PW C001969/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/ChemSpider 643307
type: UnificationXref
id: 643307
db: ChemSpider

Reference/ChemSpider 1200
type: UnificationXref
id: 1200
db: ChemSpider

Reference/CAS 156-38-7
type: UnificationXref
id: 156-38-7
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

ChemicalStructure/PW C000099
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=C(O)C=CC(O)=C1

Reference/HMDB HMDB0000291
type: UnificationXref
id: HMDB0000291
db: HMDB

Hydrogen peroxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen peroxide

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3,4-Dihydroxymandelaldehyde

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

ChemicalStructure/PW C040712
type: ChemicalStructure
structure format: SMILES
structure data: CN

Liothyronine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Liothyronine

Reference/ChemSpider 1675
type: UnificationXref
id: 1675
db: ChemSpider

Compound/PW C000074/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillic acid
stoichiometric coefficient: 1.0

Reference/BioCyc L-EPINEPHRINE
type: UnificationXref
id: L-EPINEPHRINE
db: BioCyc

Reference/PubChem-compound 5280393
type: UnificationXref
id: 5280393
db: PubChem-compound

Compound/PW C000222/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylglycol
stoichiometric coefficient: 1.0

Melanin Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110245
pathway component: SubPathwayInteraction110245
xref: Reference/SMPDB SMP0121221
xref: Reference/PathWhiz PW122515
name: SubPathway

Reference/KEGG Compound C01060
type: UnificationXref
id: C01060
db: KEGG Compound

Reference/HMDB HMDB0000068
type: UnificationXref
id: HMDB0000068
db: HMDB

Reference/PubChem-compound 5280398
type: UnificationXref
id: 5280398
db: PubChem-compound

ChemicalStructure/PW C002043
type: ChemicalStructure
structure format: SMILES
structure data: CNCC(O)C1=CC(OC)=C(O)C=C1

ChemicalStructure/PW C002044
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CC2=CC(O)=C(O)C=C2N1

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Reference/KEGG Compound C01061
type: UnificationXref
id: C01061
db: KEGG Compound

Tyrosine Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2125380
pathway order: PathwayEnzymeReaction/2125382
pathway order: PathwayEnzymeReaction/2125381
pathway order: PathwayEnzymeReaction/2125384
pathway order: PathwayEnzymeReaction/2125361
pathway order: PathwayEnzymeReaction/2125383
pathway order: PathwayEnzymeReaction/2125385
pathway order: PathwayEnzymeReaction/2125366
pathway order: PathwayEnzymeReaction/2125388
pathway order: PathwayEnzymeReaction/2125421
pathway order: PathwayEnzymeReaction/2125387
pathway order: PathwayEnzymeReaction/2125420
pathway order: PathwayEnzymeReaction/2125368
pathway order: PathwayEnzymeReaction/2125367
pathway order: PathwayEnzymeReaction/2125389
pathway order: PathwayEnzymeReaction/2125400
pathway order: PathwayEnzymeReaction/2125403
pathway order: PathwayEnzymeReaction/2125369
pathway order: PathwayEnzymeReaction/2125402
pathway order: PathwayEnzymeReaction/2125405
pathway order: PathwayEnzymeReaction/2125404
pathway order: PathwayEnzymeReaction/2125407
pathway order: PathwayEnzymeReaction/2125409
pathway order: PathwaySubPathway/110245
pathway order: PathwaySubPathway/110241
pathway order: PathwayEnzymeReaction/2125391
pathway order: PathwayEnzymeReaction/2125371
pathway order: PathwayEnzymeReaction/2125370
pathway order: PathwayEnzymeReaction/2125373
pathway order: PathwayEnzymeReaction/2125395
pathway order: PathwayEnzymeReaction/2125372
pathway order: PathwayEnzymeReaction/2125394
pathway order: PathwayEnzymeReaction/2125375
pathway order: PathwayEnzymeReaction/2125397
pathway order: PathwayEnzymeReaction/2125374
pathway order: PathwayEnzymeReaction/2125396
pathway order: PathwayEnzymeReaction/2125377
pathway order: PathwayEnzymeReaction/2125399
pathway order: PathwayEnzymeReaction/2125410
pathway order: PathwayEnzymeReaction/2125376
pathway order: PathwayEnzymeReaction/2125398
pathway order: PathwayEnzymeReaction/2125379
pathway order: PathwayEnzymeReaction/2125412
pathway order: PathwayEnzymeReaction/2125378
pathway order: PathwayEnzymeReaction/2125411
pathway order: PathwaySubPathway/110238
pathway order: PathwaySubPathway/110237
pathway order: PathwayEnzymeReaction/2125419
pathway component: Reaction180216
pathway component: Reaction180218
pathway component: Reaction180256
pathway component: Reaction180255
pathway component: Reaction180214
pathway component: Reaction180213
pathway component: Reaction180219
pathway component: ReactionCatalysis170086
pathway component: ReactionCatalysis170085
pathway component: ReactionCatalysis170088
pathway component: ReactionCatalysis170087
pathway component: ReactionCatalysis170089
pathway component: Pyruvate metabolism
pathway component: Citrate cycle
pathway component: ReactionCatalysis170080
pathway component: Reaction180254
pathway component: ReactionCatalysis170082
pathway component: ReactionCatalysis170081
pathway component: ReactionCatalysis170084
pathway component: Reaction180250
pathway component: ReactionCatalysis170083
pathway component: Reaction180249
pathway component: Reaction180248
pathway component: Reaction180245
pathway component: Reaction180244
pathway component: Reaction180247
pathway component: Melanin Biosynthesis
pathway component: ReactionCatalysis170097
pathway component: ReactionCatalysis170096
pathway component: ReactionCatalysis170098
pathway component: Reaction180241

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

ChemicalStructure/PW C002041
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C=CC(=C1)C(O)C=O

ChemicalStructure/PW C002042
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC(C=O)=C(O)C=C1

Compound/PW C104791/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cysteinyldopa
stoichiometric coefficient: 1.0

Reference/CAS 28613-33-4
type: UnificationXref
id: 28613-33-4
db: CAS

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/UniProt M1ZMM0
type: UnificationXref
id: M1ZMM0
db: UniProt

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Compound/PW C000222 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylglycol
stoichiometric coefficient: 1.0

Reference/ChemSpider 759
type: UnificationXref
id: 759
db: ChemSpider

Reference/KEGG Compound C05422
type: UnificationXref
id: C05422
db: KEGG Compound

L-Dopa
type: SmallMolecule
entity reference: L-Dopa

Reference/CAS 10034-85-2
type: UnificationXref
id: 10034-85-2
db: CAS

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

ChemicalStructure/PW C000074
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(CC(O)=O)=CC=C1O

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3,4-Dihydroxymandelaldehyde

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

L-Tyrosine
type: SmallMolecule
entity reference: L-Tyrosine
name: SubPathwayOutput

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/CAS 1194-98-5
type: UnificationXref
id: 1194-98-5
db: CAS

ChemicalStructure/PW C000084
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=C(O)C=CC(O)=C1

Compound/PW C003007/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 70949
type: UnificationXref
id: 70949
db: PubChem-compound

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Reference/PubChem-compound 7058163
type: UnificationXref
id: 7058163
db: PubChem-compound

Reference/BioCyc CPD-7650
type: UnificationXref
id: CPD-7650
db: BioCyc

Compound/PW C001420 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 28918
type: UnificationXref
id: CHEBI:28918
db: ChEBI

Reference/PubChem-compound 5610
type: UnificationXref
id: 5610
db: PubChem-compound

Amine oxidase [flavin-containing]
type: Protein
cellular location: Mitochondrion
entity reference: Amine oxidase [flavin-containing]

3,4-Dihydroxybenzeneacetic acid
type: SmallMolecule
entity reference: 3,4-Dihydroxybenzeneacetic acid

Ascorbic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ascorbic acid

Reference/BioCyc P-HYDROXY-PHENYLPYRUVATE
type: UnificationXref
id: P-HYDROXY-PHENYLPYRUVATE
db: BioCyc

3,4-Dihydroxymandelic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 85782
xref: Reference/HMDB HMDB0001866
xref: Reference/KEGG Compound C05580
xref: Reference/ChEBI CHEBI 27637
xref: Reference/CAS 775-01-9
xref: Reference/ChemSpider 77371
chemical formula: C8H8O5
molecular weight: 184.03717
structure: ChemicalStructure/PW C001240

Thyroxine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Thyroxine

Normetanephrine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Normetanephrine

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChemSpider 4573572
type: UnificationXref
id: 4573572
db: ChemSpider

Reference/BioCyc CPD-782
type: UnificationXref
id: CPD-782
db: BioCyc

Reference/ChemSpider 124
type: UnificationXref
id: 124
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Reference/UniProt Q7ZWF5
type: UnificationXref
id: Q7ZWF5
db: UniProt

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid
name: SubPathwayInput

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Compound/PW C001969 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxyphenylacetaldehyde
stoichiometric coefficient: 1.0

Compound/PW C000142 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

3,5-Diiodo-L-tyrosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3,5-Diiodo-L-tyrosine

4-Hydroxyphenylpyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 4-Hydroxyphenylpyruvic acid

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Reference/HMDB HMDB0000675
type: UnificationXref
id: HMDB0000675
db: HMDB

3,4-Dihydroxymandelic acid
type: SmallMolecule
entity reference: 3,4-Dihydroxymandelic acid

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/CAS 4430-97-1 25520-73-4
type: UnificationXref
id: 4430-97-1 25520-73-4
db: CAS

Compound/PW C000448/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Aspartate aminotransferase
type: Protein
cellular location: Mitochondrion
entity reference: Aspartate aminotransferase

ChemicalStructure/PW C000558
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=O)CC1=CC=C(O)C=C1

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

NADP
type: SmallMolecule
entity reference: NADP

Norepinephrine
type: SmallMolecule
entity reference: Norepinephrine

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Compound/PW C000558/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenylpyruvic acid
stoichiometric coefficient: 1.0

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Reference/UniProt F1QRA1
type: UnificationXref
id: F1QRA1
db: UniProt

Reference/ChemSpider 4444078
type: UnificationXref
id: 4444078
db: ChemSpider

Reference/CAS 51-43-4
type: UnificationXref
id: 51-43-4
db: CAS

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Cysteinyldopa
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 81392
xref: Reference/CAS 19641-92-0
xref: Reference/KEGG Compound C17935
xref: Reference/PubChem-compound 96024156
chemical formula: C12H16N2O6S
molecular weight: 316.0729
structure: ChemicalStructure/PW C104791

Dehydroascorbate
type: SmallMoleculeReference
xref: Reference/CAS 490-83-5
xref: Reference/ChEBI CHEBI 27956
xref: Reference/KEGG Compound C05422
xref: Reference/PubChem-compound 7786
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C104792

2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
type: SmallMolecule
entity reference: 2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Compound/PW C001904 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3,5-Diiodo-L-tyrosine
stoichiometric coefficient: 2.0

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/ChEBI CHEBI 742324
type: UnificationXref
id: CHEBI:742324
db: ChEBI

Reference/PubChem-compound 5816
type: UnificationXref
id: 5816
db: PubChem-compound

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/ChEBI CHEBI 27637
type: UnificationXref
id: CHEBI:27637
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Vanillylmandelic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 643307
xref: Reference/KEGG Compound C05584
xref: Reference/CAS 55-10-7
xref: Reference/HMDB HMDB0000291
xref: Reference/ChEBI CHEBI 1127735
xref: Reference/PubChem-compound 736172
chemical formula: C9H10O5
molecular weight: 198.05283
structure: ChemicalStructure/PW C000197

Reference/ChemSpider 1606
type: UnificationXref
id: 1606
db: ChemSpider

Compound/PW C001376/Stoichiometry/1.0
type: Stoichiometry
physical entity: Maleylacetoacetic acid
stoichiometric coefficient: 1.0

3-Fumarylpyruvate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1506
xref: Reference/KEGG Compound C02514
xref: Reference/PubChem-compound 5524
chemical formula: C7H6O6
molecular weight: 186.01643
structure: ChemicalStructure/PW C104789

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/CAS 7553-56-2
type: UnificationXref
id: 7553-56-2
db: CAS

Eosinophil peroxidase
type: Protein
cellular location: Cytoplasm
entity reference: Eosinophil peroxidase

Compound/PW C000654 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Normetanephrine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/BioCyc 4-FUMARYL-ACETOACETATE
type: UnificationXref
id: 4-FUMARYL-ACETOACETATE
db: BioCyc

Amine oxidase
type: Protein
entity reference: Amine oxidase

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytoplasm
entity reference: Dopamine beta-hydroxylase

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C040712 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylammonium
stoichiometric coefficient: 1.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Reference/ChEBI CHEBI 15621
type: UnificationXref
id: CHEBI:15621
db: ChEBI

Reference/CAS 51-67-2
type: UnificationXref
id: 51-67-2
db: CAS

Thyroxine
type: SmallMoleculeReference
xref: Reference/CAS 51-48-9
xref: Reference/PubChem-compound 25201348
xref: Reference/HMDB HMDB0000248
xref: Reference/ChemSpider 5614
xref: Reference/KEGG Compound C01829
xref: Reference/BioCyc L-THYROXINE
xref: Reference/ChEBI CHEBI 18332
chemical formula: C15H11I4NO4
molecular weight: 776.6867
structure: ChemicalStructure/PW C000169

Reference/ChEBI CHEBI 27847
type: UnificationXref
id: CHEBI:27847
db: ChEBI

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/ChEBI CHEBI 1127735
type: UnificationXref
id: CHEBI:1127735
db: ChEBI

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/ChEBI CHEBI 27852
type: UnificationXref
id: CHEBI:27852
db: ChEBI

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen peroxide

Reference/PubChem-compound 1237
type: UnificationXref
id: 1237
db: PubChem-compound

Vanillylmandelic acid
type: SmallMolecule
entity reference: Vanillylmandelic acid

Reference/KEGG Compound C00822
type: UnificationXref
id: C00822
db: KEGG Compound

Compound/PW C000013/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Hydroxyphenylacetic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O

3,4-Dihydroxybenzeneacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 41941
xref: Reference/ChemSpider 532
xref: Reference/HMDB HMDB0001336
xref: Reference/KEGG Compound C01161
xref: Reference/PubChem-compound 547
xref: Reference/CAS 102-32-9
xref: Reference/BioCyc CPD-782
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C001029

Reference/CAS 5001-33-2
type: UnificationXref
id: 5001-33-2
db: CAS

Tyr protein
type: Protein
entity reference: Tyr protein

Liothyronine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000265
xref: Reference/CAS 6893-02-3
xref: Reference/ChEBI CHEBI 18258
xref: Reference/BioCyc LIOTHYRONINE
xref: Reference/PubChem-compound 5920
xref: Reference/ChemSpider 5707
xref: Reference/KEGG Compound C02465
chemical formula: C15H12I3NO4
molecular weight: 650.79004
structure: ChemicalStructure/PW C000181

Zgc:109929
type: Protein
entity reference: Zgc:109929

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/HMDB HMDB0000248
type: UnificationXref
id: HMDB0000248
db: HMDB

Uncharacterized protein
type: Protein
entity reference: Uncharacterized protein

Reference/HMDB HMDB0001336
type: UnificationXref
id: HMDB0001336
db: HMDB

Compound/PW C002042 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gentisate aldehyde
stoichiometric coefficient: 1.0

Catechol O-methyltransferase A
type: Protein
entity reference: Catechol O-methyltransferase A

Reference/ChEBI CHEBI 60872
type: UnificationXref
id: CHEBI:60872
db: ChEBI

Reference/CAS 74-89-5
type: UnificationXref
id: 74-89-5
db: CAS

Reference/CAS 5707-55-1
type: UnificationXref
id: 5707-55-1
db: CAS

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q6NXA6
type: UnificationXref
id: Q6NXA6
db: UniProt

Reference/PubChem-compound 5459802
type: UnificationXref
id: 5459802
db: PubChem-compound

Reference/ChEBI CHEBI 28508
type: UnificationXref
id: CHEBI:28508
db: ChEBI

Compound/PW C002683/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000819
type: UnificationXref
id: HMDB0000819
db: HMDB

Reference/ChemSpider 77371
type: UnificationXref
id: 77371
db: ChemSpider

ChemicalStructure/PW C000981
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)CC(=O)\C=C/C(O)=O

Danio rerio
type: BioSource
xref: Reference/TAXONOMY 7955

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChemSpider 106504
type: UnificationXref
id: 106504
db: ChemSpider

Reference/PubChem-compound 6329
type: UnificationXref
id: 6329
db: PubChem-compound

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 6893-02-3
type: UnificationXref
id: 6893-02-3
db: CAS

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ReactionCatalysis170101
type: Catalysis
controller: Catechol O-methyltransferase A
controlled: Reaction180248
control type: ACTIVATION

ReactionCatalysis170100
type: Catalysis
controller: Catechol O-methyltransferase A
controlled: Reaction180247
control type: ACTIVATION

ReactionCatalysis170103
type: Catalysis
controller: Aldehyde dehydrogenase
controlled: Reaction180250
control type: ACTIVATION

Reference/PubChem-compound 151725
type: UnificationXref
id: 151725
db: PubChem-compound

ReactionCatalysis170102
type: Catalysis
controller: Amine oxidase [flavin-containing]
controlled: Reaction180249
control type: ACTIVATION

Reference/KEGG Compound C00628
type: UnificationXref
id: C00628
db: KEGG Compound

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 552441
xref: Reference/HMDB HMDB0006915
xref: Reference/KEGG Compound C05350
xref: Reference/ChEBI CHEBI 27683
xref: Reference/PubChem-compound 636708
chemical formula: C9H8O4
molecular weight: 180.04225
structure: ChemicalStructure/PW C003007

ChemicalStructure/PW C000952
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC(=O)C(=O)C=C1)C(O)=O

ReactionCatalysis170107
type: Catalysis
controller: Uncharacterized protein
controlled: Reaction180254
control type: ACTIVATION

ReactionCatalysis170109
type: Catalysis
controller: Amine oxidase [flavin-containing]
controlled: Reaction180256
control type: ACTIVATION

ReactionCatalysis170108
type: Catalysis
controller: Catechol O-methyltransferase A
controlled: Reaction180255
control type: ACTIVATION

Compound/PW C104792 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbate
stoichiometric coefficient: 1.0

Compound/PW C000558 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenylpyruvic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17606
type: UnificationXref
id: CHEBI:17606
db: ChEBI

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000052/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/CAS 89762-39-0
type: UnificationXref
id: 89762-39-0
db: CAS

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 81392
type: UnificationXref
id: CHEBI:81392
db: ChEBI

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C000042 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000532
type: ChemicalStructure
structure format: SMILES
structure data: II

Metanephrine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Metanephrine

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/ChEBI CHEBI 41941
type: UnificationXref
id: CHEBI:41941
db: ChEBI

Compound/PW C000084/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homogentisic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 3469
type: UnificationXref
id: 3469
db: PubChem-compound

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/KEGG Compound C00642
type: UnificationXref
id: C00642
db: KEGG Compound

3-Methoxy-4-hydroxyphenylglycolaldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 3-Methoxy-4-hydroxyphenylglycolaldehyde

Compound/PW C002411 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homovanillin
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/UniProt Q504L5
type: UnificationXref
id: Q504L5
db: UniProt

Reference/ChEBI CHEBI 545959
type: UnificationXref
id: CHEBI:545959
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Aldehyde dehydrogenase
type: Protein
entity reference: Aldehyde dehydrogenase

Compound/PW C000099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gentisic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000210 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tyramine
stoichiometric coefficient: 1.0

Fumarylacetoacetase
type: Protein
cellular location: Cytosol
entity reference: Fumarylacetoacetase

Reference/ChemSpider 389113
type: UnificationXref
id: 389113
db: ChemSpider

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Compound/PW C001240/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27683
type: UnificationXref
id: CHEBI:27683
db: ChEBI

Reference/BioCyc 4-MALEYL-ACETOACETATE
type: UnificationXref
id: 4-MALEYL-ACETOACETATE
db: BioCyc