Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

L-lactate dehydrogenase
type: Complex
component stoichiometry: Protein/22942 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: L-lactate dehydrogenase A chain

Reference/ChemSpider 96860
type: UnificationXref
id: 96860
db: ChemSpider

Reference/ChemSpider 388473
type: UnificationXref
id: 388473
db: ChemSpider

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Ferrocytochrome c
type: Protein
cellular location: Mitochondrion
entity reference: Ferrocytochrome c

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/UniProt Q6P963
type: UnificationXref
id: Q6P963
db: UniProt

Compound/PW C001991/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-(a-Hydroxyethyl)thiamine diphosphate
stoichiometric coefficient: 1.0

Phosphoenolpyruvate carboxykinase 1 (Soluble)
type: Protein
cellular location: Cytosol
entity reference: Phosphoenolpyruvate carboxykinase 1 (Soluble)

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001066
type: UnificationXref
id: HMDB0001066
db: HMDB

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

NAD
type: SmallMolecule
entity reference: NAD

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

S-Lactoylglutathione
type: SmallMolecule
entity reference: S-Lactoylglutathione

Protein N6-(lipoyl)lysine
type: ProteinReference
organism: Danio rerio

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 440018
type: UnificationXref
id: 440018
db: PubChem-compound

Reference/ChEBI CHEBI 978
type: UnificationXref
id: CHEBI:978
db: ChEBI

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetoacetyl-CoA

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Malate dehydrogenase
type: Protein
cellular location: Mitochondrion
entity reference: Malate dehydrogenase

Reference/HMDB HMDB0006880
type: UnificationXref
id: HMDB0006880
db: HMDB

Reference/BioCyc D-LACTATE
type: UnificationXref
id: D-LACTATE
db: BioCyc

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl-CoA

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Compound/PW C000905/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvaldehyde
stoichiometric coefficient: 1.0

Reference/UniProt Q7T3D9
type: UnificationXref
id: Q7T3D9
db: UniProt

Reference/CAS 154-87-0
type: UnificationXref
id: 154-87-0
db: CAS

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

Reference/TAXONOMY 7955
type: UnificationXref
id: 7955
db: TAXONOMY

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/KEGG Compound C00227
type: UnificationXref
id: C00227
db: KEGG Compound

Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/CAS 13015-87-7
type: UnificationXref
id: 13015-87-7
db: CAS

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 10326-41-7
type: UnificationXref
id: 10326-41-7
db: CAS

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Compound/PW C000080 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Fumaric acid

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Compound/PW C000463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Compound/PW C000936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoenolpyruvic acid

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 17158
type: UnificationXref
id: CHEBI:17158
db: ChEBI

Reference/CAS 10055-47-7
type: UnificationXref
id: 10055-47-7
db: CAS

Reference/PubChem-compound C16255
type: UnificationXref
id: C16255
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001010 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyruvic acid

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Compound/PW C000148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/PathWhiz PW122513
type: UnificationXref
id: PW122513
db: PathWhiz

Ferricytochrome c
type: Protein
cellular location: Mitochondrion
entity reference: Ferricytochrome c

S-Acetyldihydrolipoamide-E
type: Protein
cellular location: Mitochondrion
entity reference: S-Acetyldihydrolipoamide-E

ChemicalStructure/PW C000905
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C=O

Reaction180278
type: BiochemicalReaction
participant stoichiometry: Protein/Generic265/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001991/Stoichiometry/1.0
participant stoichiometry: Protein/Generic201/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060/Stoichiometry/1.0
right: S-Acetyldihydrolipoamide-E
right: Thiamine pyrophosphate
spontaneous: false
left: 2-(a-Hydroxyethyl)thiamine diphosphate
left: Protein N6-(lipoyl)lysine
name: 2-(a-Hydroxyethyl)thiamine diphosphate + Protein N6-(lipoyl)lysine → S-Acetyldihydrolipoamide-E + Thiamine pyrophosphate
conversion direction: LEFT_TO_RIGHT

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001991/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060/Stoichiometry/1.0
right: 2-(a-Hydroxyethyl)thiamine diphosphate
right: Carbon dioxide
spontaneous: false
EC number: 1.2.4.1
left: Pyruvic acid
left: Thiamine pyrophosphate
name: Pyruvic acid + Thiamine pyrophosphate → 2-(a-Hydroxyethyl)thiamine diphosphate + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q7ZU18
type: UnificationXref
id: Q7ZU18
db: UniProt

S-Lactoylglutathione
type: SmallMoleculeReference
xref: Reference/CAS 25138-66-3
xref: Reference/BioCyc S-LACTOYL-GLUTATHIONE
xref: Reference/KEGG Compound C03451
xref: Reference/ChemSpider 389032
xref: Reference/PubChem-compound 440018
xref: Reference/ChEBI CHEBI 15694
xref: Reference/HMDB HMDB0001066
chemical formula: C13H21N3O8S
molecular weight: 379.10495
structure: ChemicalStructure/PW C000841

Reference/PubChem-compound 107689
type: UnificationXref
id: 107689
db: PubChem-compound

2.3.1.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic543 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic265 Mitochondrion/Stoichiometry/1.0
right: Acetyl-CoA
right: Protein N6-(dihydrolipoyl)lysine
spontaneous: false
EC number: 2.3.1.12
left: Coenzyme A
left: S-Acetyldihydrolipoamide-E
name: Coenzyme A + S-Acetyldihydrolipoamide-E ↔ Acetyl-CoA + Protein N6-(dihydrolipoyl)lysine
conversion direction: REVERSIBLE

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

D-Lactic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: D-Lactic acid

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/CAS 3946-09-6
type: UnificationXref
id: 3946-09-6
db: CAS

Reference/KEGG Compound C00256
type: UnificationXref
id: C00256
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/HMDB HMDB0006458
type: UnificationXref
id: HMDB0006458
db: HMDB

4.4.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000905/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000841/Stoichiometry/1.0
right: S-Lactoylglutathione
spontaneous: false
EC number: 4.4.1.5
left: Pyruvaldehyde
left: Glutathione
name: Glutathione + Pyruvaldehyde ↔ S-Lactoylglutathione
conversion direction: REVERSIBLE

3.1.2.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000841 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001010 Mitochondrion/Stoichiometry/1.0
right: D-Lactic acid
right: Glutathione
spontaneous: false
EC number: 3.1.2.6
left: S-Lactoylglutathione
left: Water
name: S-Lactoylglutathione + Water → D-Lactic acid + Glutathione
conversion direction: LEFT_TO_RIGHT

1.1.1.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000122 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Lactic acid
right: NAD
spontaneous: false
EC number: 1.1.1.27
left: Pyruvic acid
left: Hydrogen Ion
left: NADH
name: Hydrogen Ion + NADH + Pyruvic acid ↔ Hydrogen Ion + L-Lactic acid + NAD
conversion direction: REVERSIBLE

Reaction180275
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002750 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000905 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: D-Lactaldehyde
right: NAD
spontaneous: false
left: Pyruvaldehyde
left: Hydrogen Ion
left: NADH
name: Hydrogen Ion + NADH + Pyruvaldehyde ↔ D-Lactaldehyde + NAD
conversion direction: REVERSIBLE

Reaction180272
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Protein/Generic17 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001010 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic16 Mitochondrion/Stoichiometry/2.0
right: Ferrocytochrome c
right: Hydrogen Ion
right: Pyruvic acid
spontaneous: false
left: Ferricytochrome c
left: D-Lactic acid
name: D-Lactic acid + 2 Ferricytochrome c → 2 Ferrocytochrome c + 2 Hydrogen Ion + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

4.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrion/Stoichiometry/1.0
right: Water
right: Fumaric acid
spontaneous: false
EC number: 4.2.1.2
left: L-Malic acid
name: L-Malic acid ↔ Fumaric acid + Water
conversion direction: REVERSIBLE

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid

Reference/CAS 25138-66-3
type: UnificationXref
id: 25138-66-3
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Pyruvaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvaldehyde

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

1.1.1.37
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
right: NAD
right: L-Malic acid
spontaneous: false
EC number: 1.1.1.37
left: Oxalacetic acid
left: Hydrogen Ion
left: NADH
name: Hydrogen Ion + NADH + Oxalacetic acid ↔ L-Malic acid + NAD
conversion direction: REVERSIBLE

Reaction180269
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
right: Carbon dioxide
right: Hydrogen Ion
right: Pyruvic acid
right: NADH
spontaneous: false
left: NAD
left: L-Malic acid
name: L-Malic acid + NAD ↔ Carbon dioxide + Hydrogen Ion + NADH + Pyruvic acid
conversion direction: REVERSIBLE

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Pyruvate carboxylase
type: Protein
cellular location: Cytoplasm
entity reference: Pyruvate carboxylase

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q7SXK3
type: UnificationXref
id: Q7SXK3
db: UniProt

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

2.7.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: Adenosine triphosphate
spontaneous: false
EC number: 2.7.1.40
left: Adenosine diphosphate
left: Phosphoenolpyruvic acid
name: Adenosine diphosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

6.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Oxalacetic acid
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
EC number: 6.4.1.1
left: Pyruvic acid
left: Hydrogen carbonate
left: Adenosine triphosphate
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction180264
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
right: Guanosine diphosphate
right: Carbon dioxide
right: Phosphoenolpyruvic acid
spontaneous: false
left: Oxalacetic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Oxalacetic acid ↔ Carbon dioxide + Guanosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Compound/PW C000080/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Acetyltransferase component of pyruvate dehydrogenase complex
type: ProteinReference
xref: Reference/UniProt B3DIV6
organism: Danio rerio

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Dihydrolipoyl dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q803L1
organism: Danio rerio

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Pyruvate dehydrogenase E1 component subunit beta
type: ProteinReference
xref: Reference/UniProt Q7T368
organism: Danio rerio

Glyoxylate reductase/hydroxypyruvate reductase b
type: ProteinReference
xref: Reference/UniProt F1QYH7
organism: Danio rerio

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

L-lactate dehydrogenase A chain
type: ProteinReference
xref: Reference/UniProt Q9PVK5
organism: Danio rerio

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/PubChem-compound 880
type: UnificationXref
id: 880
db: PubChem-compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Oxalacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalacetic acid

Reference/CAS 590-54-5
type: UnificationXref
id: 590-54-5
db: CAS

L-lactate dehydrogenase A chain
type: Protein
cellular location: Cytoplasm
entity reference: L-lactate dehydrogenase A chain

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Fumarate hydratase
type: Complex
component stoichiometry: Protein/22935 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Fumarate hydratase, mitochondrial

Reference/SMPDB SMP0121223
type: UnificationXref
id: SMP0121223
db: SMPDB

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Acyl-CoA synthetase short chain family member 2
type: ProteinReference
xref: Reference/UniProt F1QAA7
organism: Danio rerio

Acylphosphatase
type: ProteinReference
xref: Reference/UniProt A3KPA7
organism: Danio rerio

Acetyl-CoA carboxylase beta
type: ProteinReference
xref: Reference/UniProt F1QM37
organism: Danio rerio

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Acetyl adenylate
type: SmallMolecule
entity reference: Acetyl adenylate

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Protein/Generic265/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Acetyldihydrolipoamide-E
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt E7FCU2
organism: Danio rerio

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Reference/ChEBI CHEBI 9532
type: UnificationXref
id: CHEBI:9532
db: ChEBI

3.6.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001151/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Phosphate
right: Acetic acid
spontaneous: false
EC number: 3.6.1.7
left: Water
left: Acetylphosphate
name: Acetylphosphate + Water → Acetic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reaction180284
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
name: 2 Acetyl-CoA → Acetoacetyl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reaction180286
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Malonyl-CoA
spontaneous: false
left: Hydrogen carbonate
left: Acetyl-CoA
left: Adenosine triphosphate
name: Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate → Adenosine diphosphate + Malonyl-CoA + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction180281
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Cytosol/Stoichiometry/1.0
right: Acetic acid
right: Coenzyme A
spontaneous: false
left: Acetyl-CoA
left: Water
name: Acetyl-CoA + Water → Acetic acid + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reference/UniProt A3KPA7
type: UnificationXref
id: A3KPA7
db: UniProt

ChemicalStructure/PW C001151
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OP(O)(O)=O

1.8.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Protein/Generic201/Stoichiometry/1.0
participant stoichiometry: Compound/Generic543/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Protein N6-(lipoyl)lysine
right: Hydrogen Ion
spontaneous: false
EC number: 1.8.1.4
left: NAD
left: Protein N6-(dihydrolipoyl)lysine
name: NAD + Protein N6-(dihydrolipoyl)lysine ↔ Hydrogen Ion + NADH + Protein N6-(lipoyl)lysine
conversion direction: REVERSIBLE

Reaction180283
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002987/Stoichiometry/1.0
right: Acetic acid
right: Adenosine triphosphate
spontaneous: false
left: Pyrophosphate
left: Acetyl adenylate
name: Acetyl adenylate + Pyrophosphate ↔ Acetic acid + Adenosine triphosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reaction180282
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002987/Stoichiometry/1.0
right: Adenosine monophosphate
right: Acetyl-CoA
spontaneous: false
left: Coenzyme A
left: Acetyl adenylate
name: Acetyl adenylate + Coenzyme A ↔ Acetyl-CoA + Adenosine monophosphate
conversion direction: REVERSIBLE

Ferricytochrome c
type: ProteinReference
xref: Reference/ChEBI CHEBI 15991
organism: Danio rerio

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen carbonate

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/BioCyc CPD-358
type: UnificationXref
id: CPD-358
db: BioCyc

Reference/UniProt A5PN55
type: UnificationXref
id: A5PN55
db: UniProt

Protein/Generic265 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Acetyldihydrolipoamide-E
stoichiometric coefficient: 1.0

Reference/ChemSpider 389703
type: UnificationXref
id: 389703
db: ChemSpider

Reference/CAS 78-98-8
type: UnificationXref
id: 78-98-8
db: CAS

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 17167
type: UnificationXref
id: CHEBI:17167
db: ChEBI

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/PathWhiz PW122517
type: UnificationXref
id: PW122517
db: PathWhiz

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Ferrocytochrome c
type: ProteinReference
xref: Reference/ChEBI CHEBI 16928
organism: Danio rerio

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C03451
type: UnificationXref
id: C03451
db: KEGG Compound

Reference/UniProt Q803L1
type: UnificationXref
id: Q803L1
db: UniProt

Acat2 protein
type: Protein
cellular location: Mitochondrion
entity reference: Acat2 protein

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/SMPDB SMP0121219
type: UnificationXref
id: SMP0121219
db: SMPDB

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C00186
type: UnificationXref
id: C00186
db: KEGG Compound

Compound/Generic543/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein N6-(dihydrolipoyl)lysine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05993
type: UnificationXref
id: C05993
db: KEGG Compound

Acat2 protein
type: ProteinReference
xref: Reference/UniProt Q7ZU18
organism: Danio rerio

Reference/KEGG Compound C00068
type: UnificationXref
id: C00068
db: KEGG Compound

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

2-(a-Hydroxyethyl)thiamine diphosphate
type: SmallMolecule
entity reference: 2-(a-Hydroxyethyl)thiamine diphosphate

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C001010
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C(O)=O

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Protein/Generic17 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ferricytochrome c
stoichiometric coefficient: 2.0

2-(a-Hydroxyethyl)thiamine diphosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 389468
xref: Reference/CAS 10055-47-7
xref: Reference/HMDB HMDB0003904
xref: Reference/KEGG Compound C05125
xref: Reference/PubChem-compound 440568
xref: Reference/ChEBI CHEBI 978
chemical formula: C14H23N4O8P2S
molecular weight: 469.0712
structure: ChemicalStructure/PW C001991

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/HMDB HMDB0001494
type: UnificationXref
id: HMDB0001494
db: HMDB

Reference/HMDB HMDB0001372
type: UnificationXref
id: HMDB0001372
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt Q7T368
type: UnificationXref
id: Q7T368
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/ChemSpider 857
type: UnificationXref
id: 857
db: ChemSpider

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C000940 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 42111
type: UnificationXref
id: CHEBI:42111
db: ChEBI

ChemicalStructure/PW C001060
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCO[P@](O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N

Pyruvate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2125450
pathway order: PathwayEnzymeReaction/2125460
pathway order: PathwayEnzymeReaction/2125430
pathway order: PathwayEnzymeReaction/2125441
pathway order: PathwayEnzymeReaction/2125452
pathway order: PathwayEnzymeReaction/2125451
pathway order: PathwayEnzymeReaction/2125462
pathway order: PathwayEnzymeReaction/2125443
pathway order: PathwayEnzymeReaction/2125454
pathway order: PathwayEnzymeReaction/2125431
pathway order: PathwayEnzymeReaction/2125453
pathway order: PathwayEnzymeReaction/2125434
pathway order: PathwayEnzymeReaction/2125445
pathway order: PathwayEnzymeReaction/2125456
pathway order: PathwayEnzymeReaction/2125455
pathway order: PathwayEnzymeReaction/2125446
pathway order: PathwayEnzymeReaction/2125457
pathway order: PathwayEnzymeReaction/2125448
pathway order: PathwayEnzymeReaction/2125459
pathway order: PathwayEnzymeReaction/2125429
pathway order: PathwayEnzymeReaction/2125439
pathway order: PathwaySubPathway/110246
pathway component: Reaction180278
pathway component: 1.2.4.1
pathway component: 2.3.1.12
pathway component: ReactionCatalysis170116
pathway component: ReactionCatalysis170115
pathway component: ReactionCatalysis170119
pathway component: ReactionCatalysis170121
pathway component: ReactionCatalysis170123
pathway component: ReactionCatalysis170122
pathway component: ReactionCatalysis170125
pathway component: ReactionCatalysis170124
pathway component: 4.4.1.5
pathway component: 3.1.2.6
pathway component: 1.1.1.27
pathway component: Reaction180275
pathway component: Reaction180272
pathway component: 4.2.1.2
pathway component: 1.1.1.37
pathway component: Reaction180269
pathway component: ReactionCatalysis170127
pathway component: ReactionCatalysis170126
pathway component: ReactionCatalysis170129
pathway component: ReactionCatalysis170128
pathway component: ReactionCatalysis170130
pathway component: ReactionCatalysis170132
pathway component: ReactionCatalysis170131
pathway component: ReactionCatalysis170134
pathway component: ReactionCatalysis170133
pathway component: ReactionCatalysis170114
pathway component: ReactionCatalysis170136
pathway component: ReactionCatalysis170113
pathway component: ReactionCatalysis170135
pathway component: 2.7.1.40
pathway component: 3.6.1.7
pathway component: Tyrosine Metabolism
pathway component: Reaction180284
pathway component: 6.4.1.1
pathway component: Reaction180264
pathway component: Reaction180286
pathway component: Reaction180281
pathway component: 1.8.1.4
pathway component: Reaction180283
pathway component: Reaction180282
xref: Reference/SMPDB SMP0121223
xref: Reference/PathWhiz PW122517
organism: Danio rerio

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Compound/PW C002750 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactaldehyde
stoichiometric coefficient: 1.0

Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110246
pathway component: SubPathwayInteraction110246
xref: Reference/PathWhiz PW122513
xref: Reference/SMPDB SMP0121219
name: SubPathway

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxalacetic acid

L-Lactic acid
type: SmallMoleculeReference
xref: Reference/CAS 79-33-4
xref: Reference/ChEBI CHEBI 422
xref: Reference/HMDB HMDB0000190
xref: Reference/PubChem-compound 107689
xref: Reference/KEGG Compound C00186
xref: Reference/BioCyc L-LACTATE
xref: Reference/ChemSpider 96860
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000122

Compound/PW C000905 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvaldehyde
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Pyruvate kinase
type: Protein
cellular location: Cytoplasm
entity reference: Pyruvate kinase

Acetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetic acid

S-Acetyldihydrolipoamide-E
type: Protein
entity reference: S-Acetyldihydrolipoamide-E

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/HMDB HMDB0000190
type: UnificationXref
id: HMDB0000190
db: HMDB

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Acetyl adenylate
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL AMP
xref: Reference/ChemSpider 389703
xref: Reference/CAS 13015-87-7
xref: Reference/ChEBI CHEBI 37666
xref: Reference/PubChem-compound 440867
xref: Reference/HMDB HMDB0006880
xref: Reference/KEGG Compound C05993
chemical formula: C12H16N5O8P
molecular weight: 389.07364
structure: ChemicalStructure/PW C002987

Compound/PW C000088 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 1100
type: UnificationXref
id: 1100
db: ChemSpider

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/HMDB HMDB0001167
type: UnificationXref
id: HMDB0001167
db: HMDB

Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

D-Lactaldehyde
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-358
xref: Reference/HMDB HMDB0006458
xref: Reference/KEGG Compound C00937
xref: Reference/PubChem-compound 439350
xref: Reference/CAS 3946-09-6
xref: Reference/ChEBI CHEBI 17167
xref: Reference/ChemSpider 388473
chemical formula: C3H6O2
molecular weight: 74.03678
structure: ChemicalStructure/PW C002750

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Lactate dehydrogenase D
type: ProteinReference
xref: Reference/UniProt Q803V9
organism: Danio rerio

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Hydroxyacylglutathione hydrolase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q6P963
organism: Danio rerio

Lactoylglutathione lyase
type: ProteinReference
xref: Reference/UniProt Q6P696
organism: Danio rerio

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Malate dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q7T3D9
organism: Danio rerio

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Malic enzyme
type: ProteinReference
xref: Reference/UniProt A5PN55
organism: Danio rerio

Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q7SX99
organism: Danio rerio

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Pyruvate kinase
type: ProteinReference
xref: Reference/UniProt Q7SXK3
organism: Danio rerio

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Phosphoenolpyruvate carboxykinase 1 (Soluble)
type: ProteinReference
xref: Reference/UniProt Q7T3G9
organism: Danio rerio

Pyruvate carboxylase
type: ProteinReference
organism: Danio rerio

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Hydrogen carbonate
type: SmallMolecule
entity reference: Hydrogen carbonate

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

ChemicalStructure/PW C002987
type: ChemicalStructure
structure format: SMILES

Compound/PW C002987/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl adenylate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1132
type: UnificationXref
id: 1132
db: PubChem-compound

Compound/PW C000841 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Lactoylglutathione
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
entity reference: NADH

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C002750
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C=O

Protein N6-(dihydrolipoyl)lysine
type: SmallMolecule
entity reference: Protein N6-(dihydrolipoyl)lysine

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Compound/PW C000180 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16928
type: UnificationXref
id: CHEBI:16928
db: ChEBI

Acetyltransferase component of pyruvate dehydrogenase complex
type: Protein
cellular location: Mitochondrion
entity reference: Acetyltransferase component of pyruvate dehydrogenase complex

Compound/PW C001142 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Protein/22942 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: L-lactate dehydrogenase A chain
stoichiometric coefficient: 4.0

Hydroxyacylglutathione hydrolase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Hydroxyacylglutathione hydrolase, mitochondrial

Compound/PW C001151/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylphosphate
stoichiometric coefficient: 1.0

D-Lactic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001311
xref: Reference/ChemSpider 55423
xref: Reference/BioCyc D-LACTATE
xref: Reference/CAS 10326-41-7
xref: Reference/KEGG Compound C00256
xref: Reference/PubChem-compound 61503
xref: Reference/ChEBI CHEBI 42111
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C001010

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid
name: SubPathwayOutput

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Glyoxylate reductase/hydroxypyruvate reductase b
type: Protein
cellular location: Cytosol
entity reference: Glyoxylate reductase/hydroxypyruvate reductase b

Protein/22935 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fumarate hydratase, mitochondrial
stoichiometric coefficient: 4.0

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Protein N6-(dihydrolipoyl)lysine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Protein N6-(dihydrolipoyl)lysine

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate

Reference/ChemSpider 55423
type: UnificationXref
id: 55423
db: ChemSpider

Protein N6-(dihydrolipoyl)lysine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16832

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/UniProt E7FCU2
type: UnificationXref
id: E7FCU2
db: UniProt

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/UniProt Q9PVK5
type: UnificationXref
id: Q9PVK5
db: UniProt

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

L-Lactic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Lactic acid

Reference/BioCyc L-LACTATE
type: UnificationXref
id: L-LACTATE
db: BioCyc

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

D-Lactaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Lactaldehyde

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Protein N6-(lipoyl)lysine
type: Protein
entity reference: Protein N6-(lipoyl)lysine

Reference/UniProt F1QYH7
type: UnificationXref
id: F1QYH7
db: UniProt

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/PubChem-compound 440867
type: UnificationXref
id: 440867
db: PubChem-compound

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoenolpyruvic acid

Reference/KEGG Compound C05125
type: UnificationXref
id: C05125
db: KEGG Compound

Compound/PW C000029 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/BioCyc S-LACTOYL-GLUTATHIONE
type: UnificationXref
id: S-LACTOYL-GLUTATHIONE
db: BioCyc

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Acetyl-CoA carboxylase beta
type: Protein
entity reference: Acetyl-CoA carboxylase beta

Acylphosphatase
type: Protein
entity reference: Acylphosphatase

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Compound/PW C000841/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Lactoylglutathione
stoichiometric coefficient: 1.0

Thiamine pyrophosphate
type: SmallMolecule
entity reference: Thiamine pyrophosphate

Acyl-CoA synthetase short chain family member 2
type: Protein
entity reference: Acyl-CoA synthetase short chain family member 2

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt Q7SX99
type: UnificationXref
id: Q7SX99
db: UniProt

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 37666
type: UnificationXref
id: CHEBI:37666
db: ChEBI

Dihydrolipoyl dehydrogenase
type: Protein
entity reference: Dihydrolipoyl dehydrogenase

Reference/HMDB HMDB0001311
type: UnificationXref
id: HMDB0001311
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Pyruvate dehydrogenase E1 component subunit beta
type: Protein
entity reference: Pyruvate dehydrogenase E1 component subunit beta

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Reference/UniProt B3DIV6
type: UnificationXref
id: B3DIV6
db: UniProt

Glutathione
type: SmallMolecule
entity reference: Glutathione

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00937
type: UnificationXref
id: C00937
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Lactoylglutathione lyase
type: Protein
entity reference: Lactoylglutathione lyase

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Compound/PW C000180 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Compound/PW C000122 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lactic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

SubPathwayInteraction110246
type: Interaction
name: SubPathway110246Reaction
name: SubPathwayReaction
participant: Pyruvic acid

Protein/Generic201/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein N6-(lipoyl)lysine
stoichiometric coefficient: 1.0

Reference/UniProt F1QM37
type: UnificationXref
id: F1QM37
db: UniProt

Reference/ChEBI CHEBI 15991
type: UnificationXref
id: CHEBI:15991
db: ChEBI

Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Acetylphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00227
xref: Reference/CAS 590-54-5
xref: Reference/BioCyc ACETYL-P
xref: Reference/HMDB HMDB0001494
xref: Reference/ChemSpider 181
xref: Reference/ChEBI CHEBI 15350
xref: Reference/PubChem-compound 186
chemical formula: C2H5O5P
molecular weight: 139.98746
structure: ChemicalStructure/PW C001151

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/BioCyc ACETYL AMP
type: UnificationXref
id: ACETYL_AMP
db: BioCyc

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Acetylphosphate
type: SmallMolecule
entity reference: Acetylphosphate

ChemicalStructure/PW C000122
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)C(O)=O

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000841
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc METHYL-GLYOXAL
type: UnificationXref
id: METHYL-GLYOXAL
db: BioCyc

Reference/BioCyc ACETYL-P
type: UnificationXref
id: ACETYL-P
db: BioCyc

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc 2-(alpha-lactyl)-thpp
type: UnificationXref
id: 2-(alpha-lactyl)-thpp
db: BioCyc

Uncharacterized protein
type: Protein
cellular location: Cytosol
entity reference: Uncharacterized protein

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChEBI CHEBI 15694
type: UnificationXref
id: CHEBI:15694
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbon dioxide

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Danio rerio
type: BioSource
xref: Reference/TAXONOMY 7955

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Oxalacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxalacetic acid

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/PubChem-compound 440568
type: UnificationXref
id: 440568
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Reference/CAS 79-33-4
type: UnificationXref
id: 79-33-4
db: CAS

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Thiamine pyrophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc 2-(alpha-lactyl)-thpp
xref: Reference/ChEBI CHEBI 9532
xref: Reference/CAS 154-87-0
xref: Reference/ChemSpider 1100
xref: Reference/HMDB HMDB0001372
xref: Reference/PubChem-compound 1132
xref: Reference/KEGG Compound C00068
chemical formula: C12H19N4O7P2S
molecular weight: 425.04498
structure: ChemicalStructure/PW C001060

Protein/Generic16 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ferrocytochrome c
stoichiometric coefficient: 2.0

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 389032
type: UnificationXref
id: 389032
db: ChemSpider

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Glutathione
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Glutathione

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ReactionCatalysis170114
type: Catalysis
controller: Phosphoenolpyruvate carboxykinase 1 (Soluble)
controlled: Reaction180264
control type: ACTIVATION

Reference/UniProt Q6P696
type: UnificationXref
id: Q6P696
db: UniProt

Reference/KEGG Compound C16832
type: UnificationXref
id: C16832
db: KEGG Compound

ReactionCatalysis170113
type: Catalysis
controller: Pyruvate kinase
controlled: 2.7.1.40
control type: ACTIVATION

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Compound/Generic543 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein N6-(dihydrolipoyl)lysine
stoichiometric coefficient: 1.0

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

ReactionCatalysis170116
type: Catalysis
controller: Malate dehydrogenase
controlled: 1.1.1.37
control type: ACTIVATION

ReactionCatalysis170115
type: Catalysis
controller: Pyruvate carboxylase
controlled: 6.4.1.1
control type: ACTIVATION

Reference/UniProt F1QAA7
type: UnificationXref
id: F1QAA7
db: UniProt

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

ReactionCatalysis170119
type: Catalysis
controller: Malic enzyme
controlled: Reaction180269
control type: ACTIVATION

Pyruvaldehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001167
xref: Reference/KEGG Compound C00546
xref: Reference/ChEBI CHEBI 17158
xref: Reference/CAS 78-98-8
xref: Reference/BioCyc METHYL-GLYOXAL
xref: Reference/ChemSpider 857
xref: Reference/PubChem-compound 880
chemical formula: C3H4O2
molecular weight: 72.021126
structure: ChemicalStructure/PW C000905

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis170121
type: Catalysis
controller: Fumarate hydratase
controlled: 4.2.1.2
control type: ACTIVATION

ReactionCatalysis170123
type: Catalysis
controller: Hydroxyacylglutathione hydrolase, mitochondrial
controlled: 3.1.2.6
control type: ACTIVATION

Reference/UniProt Q803V9
type: UnificationXref
id: Q803V9
db: UniProt

ReactionCatalysis170122
type: Catalysis
controller: Lactate dehydrogenase D
controlled: Reaction180272
control type: ACTIVATION

ReactionCatalysis170125
type: Catalysis
controller: Glyoxylate reductase/hydroxypyruvate reductase b
controlled: Reaction180275
control type: ACTIVATION

ReactionCatalysis170124
type: Catalysis
controller: Lactoylglutathione lyase
controlled: 4.4.1.5
control type: ACTIVATION

S-Acetyldihydrolipoamide-E
type: ProteinReference
xref: Reference/PubChem-compound C16255
organism: Danio rerio

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ReactionCatalysis170127
type: Catalysis
controller: Pyruvate dehydrogenase E1 component subunit beta
controlled: 1.2.4.1
control type: ACTIVATION

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis170126
type: Catalysis
controller: L-lactate dehydrogenase
controlled: 1.1.1.27
control type: ACTIVATION

Reference/PubChem-compound 439350
type: UnificationXref
id: 439350
db: PubChem-compound

ReactionCatalysis170129
type: Catalysis
controller: Acetyltransferase component of pyruvate dehydrogenase complex
controlled: 2.3.1.12
control type: ACTIVATION

L-Malic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Malic acid

ReactionCatalysis170128
type: Catalysis
controller: Pyruvate dehydrogenase E1 component subunit beta
controlled: Reaction180278
control type: ACTIVATION

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Compound/PW C001060/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Lactate dehydrogenase D
type: Protein
cellular location: Mitochondrion
entity reference: Lactate dehydrogenase D

ChemicalStructure/PW C001991
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis170130
type: Catalysis
controller: Dihydrolipoyl dehydrogenase
controlled: 1.8.1.4
control type: ACTIVATION

ReactionCatalysis170132
type: Catalysis
controller: Acyl-CoA synthetase short chain family member 2
controlled: Reaction180282
control type: ACTIVATION

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCatalysis170131
type: Catalysis
controller: Uncharacterized protein
controlled: Reaction180281
control type: ACTIVATION

Reference/ChEBI CHEBI 422
type: UnificationXref
id: CHEBI:422
db: ChEBI

ReactionCatalysis170134
type: Catalysis
controller: Acat2 protein
controlled: Reaction180284
control type: ACTIVATION

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ReactionCatalysis170133
type: Catalysis
controller: Acyl-CoA synthetase short chain family member 2
controlled: Reaction180283
control type: ACTIVATION

ReactionCatalysis170136
type: Catalysis
controller: Acetyl-CoA carboxylase beta
controlled: Reaction180286
control type: ACTIVATION

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

ReactionCatalysis170135
type: Catalysis
controller: Acylphosphatase
controlled: 3.6.1.7
control type: ACTIVATION

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

Reference/PubChem-compound 61503
type: UnificationXref
id: 61503
db: PubChem-compound

Malic enzyme
type: Protein
cellular location: Mitochondrion
entity reference: Malic enzyme

S-Lactoylglutathione
type: SmallMolecule
cellular location: Mitochondrion
entity reference: S-Lactoylglutathione

Reference/ChemSpider 389468
type: UnificationXref
id: 389468
db: ChemSpider

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Malonyl-CoA
type: SmallMolecule
entity reference: Malonyl-CoA

Reference/PubChem-compound 186
type: UnificationXref
id: 186
db: PubChem-compound

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Pyruvaldehyde
type: SmallMolecule
entity reference: Pyruvaldehyde

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/KEGG Compound C00546
type: UnificationXref
id: C00546
db: KEGG Compound

Fumarate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Fumarate hydratase, mitochondrial

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0003904
type: UnificationXref
id: HMDB0003904
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/ChEBI CHEBI 15350
type: UnificationXref
id: CHEBI:15350
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/UniProt Q7T3G9
type: UnificationXref
id: Q7T3G9
db: UniProt

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/ChemSpider 181
type: UnificationXref
id: 181
db: ChemSpider