Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Protein/11860 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/ChemSpider 388356
type: UnificationXref
id: 388356
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Glutamate racemase
type: ProteinReference
xref: Reference/UniProt Q02G12
organism: Pseudomonas aeruginosa

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Compound/PW C001009/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Alanine
stoichiometric coefficient: 1.0

Reference/UniProt B7UZJ0
type: UnificationXref
id: B7UZJ0
db: UniProt

C4-dicarboxylate transport protein 1
type: ProteinReference
xref: Reference/UniProt Q02UV9

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Glucosamine 6-phosphate
type: SmallMolecule
entity reference: Glucosamine 6-phosphate

Hydrogen ion
type: SmallMoleculeReference
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C041026

Compound/PW C001906/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/UniProt A6VF30
type: UnificationXref
id: A6VF30
db: UniProt

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 16264
type: UnificationXref
id: CHEBI:16264
db: ChEBI

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 42560
type: UnificationXref
id: CHEBI:42560
db: ChEBI

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

Compound/PW C001849 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glutamic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003498
type: UnificationXref
id: HMDB0003498
db: HMDB

Compound/PW C001009/Stoichiometry/2.0
type: Stoichiometry
physical entity: D-Alanine
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00217
type: UnificationXref
id: C00217
db: KEGG Compound

Reference/CAS 31867-59-1
type: UnificationXref
id: 31867-59-1
db: CAS

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

D-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Alanine

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 8140645
type: UnificationXref
id: 8140645
db: ChemSpider

β-D-Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 388538
xref: Reference/KEGG Compound C01172
xref: Reference/ChEBI CHEBI 17719
xref: Reference/HMDB HMDB0003498
xref: Reference/PubChem-compound 439427
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001906

2.7.7.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: N-Acetyl-glucosamine 1-phosphate
right: Coenzyme A
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.7.23
left: Acetyl-CoA
left: Glucosamine-1P
name: Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction183615
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Uridine diphosphate-N-acetylglucosamine
right: Pyrophosphate
spontaneous: false
left: N-Acetyl-glucosamine 1-phosphate
left: Hydrogen Ion
left: Uridine triphosphate
name: Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00105
type: UnificationXref
id: C00105
db: KEGG Compound

Reference/PubChem-compound 6030
type: UnificationXref
id: 6030
db: PubChem-compound

5.4.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969/Stoichiometry/1.0
right: Glucosamine-1P
spontaneous: false
EC number: 5.4.2.10
left: Glucosamine 6-phosphate
name: Glucosamine 6-phosphate ↔ Glucosamine-1P
conversion direction: REVERSIBLE

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Protein/12119/Stoichiometry/2.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramate--L-alanine ligase
stoichiometric coefficient: 2.0

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

D-Alanyl-D-alanine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16576
xref: Reference/ChemSpider 4573916
xref: Reference/HMDB HMDB0003459
xref: Reference/BioCyc D-ALA-D-ALA
xref: Reference/CAS 923-16-0
xref: Reference/KEGG Compound C00993
xref: Reference/PubChem-compound 5460362
chemical formula: C6H12N2O3
molecular weight: 160.0848
structure: ChemicalStructure/PW C001900

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Phospho-N-acetylmuramoyl-pentapeptide-transferase
type: Protein
entity reference: Phospho-N-acetylmuramoyl-pentapeptide-transferase

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C001009 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Alanine
stoichiometric coefficient: 1.0

Reference/BioCyc GLUCOSAMINE-1P
type: UnificationXref
id: GLUCOSAMINE-1P
db: BioCyc

Reference/PubChem-compound 440272
type: UnificationXref
id: 440272
db: PubChem-compound

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-diphosphate

ChemicalStructure/PW C041232
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C041111
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Glucosamine-1P
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9965052
xref: Reference/BioCyc GLUCOSAMINE-1P
xref: Reference/HMDB HMDB0001109
xref: Reference/ChemSpider 8140645
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000868

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

1.3.1.98
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041114/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041026/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041115/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
right: UDP-N-acetyl-α-D-muramate
right: NADP
spontaneous: false
EC number: 1.3.1.98
left: UDP-N-acetyl-α-D-glucosamine-enolpyruvate
left: Hydrogen ion
left: NADPH
name: Hydrogen ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000868/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine-1P
stoichiometric coefficient: 1.0

2.5.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041114/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: UDP-N-acetyl-α-D-glucosamine-enolpyruvate
right: Phosphate
spontaneous: false
EC number: 2.5.1.7
left: Uridine diphosphate-N-acetylglucosamine
left: Phosphoenolpyruvic acid
name: Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate
conversion direction: LEFT_TO_RIGHT

Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMolecule
entity reference: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

UDP-N-acetylmuramate--L-alanine ligase
type: Protein
entity reference: UDP-N-acetylmuramate--L-alanine ligase

Reference/KEGG Compound C00352
type: UnificationXref
id: C00352
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/PathWhiz PW122613
type: UnificationXref
id: PW122613
db: PathWhiz

β-D-fructofuranose
type: SmallMolecule
cellular location: Inner Membrane
entity reference: β-D-fructofuranose

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Compound/PW C041114/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-α-D-glucosamine-enolpyruvate
stoichiometric coefficient: 1.0

Compound/PW C041111 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-fructofuranose
stoichiometric coefficient: 1.0

2.6.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040941/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969/Stoichiometry/1.0
right: Glucosamine 6-phosphate
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.16
left: β-D-fructofuranose 6-phosphate
left: L-Glutamine
name: L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid
conversion direction: REVERSIBLE

ReactionCoupledTransport353
type: TransportWithBiochemicalReaction
participant stoichiometry: Protein/11860 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040941 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041111 Inner Membrane/Stoichiometry/1.0
right: β-D-fructofuranose 6-phosphate
right: Unknown
spontaneous: false
left: β-D-fructofuranose
left: Unknown
name: HPr - phosphorylated + β-D-fructofuranose → HPr + β-D-fructofuranose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Unknown
type: ProteinReference

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

UDP-N-acetyl-α-D-glucosamine-enolpyruvate
type: SmallMolecule
entity reference: UDP-N-acetyl-α-D-glucosamine-enolpyruvate

D-Glutamic acid
type: SmallMoleculeReference
xref: Reference/CAS 6893-26-1
xref: Reference/KEGG Compound C00217
xref: Reference/ChemSpider 21814
xref: Reference/ChEBI CHEBI 15966
xref: Reference/HMDB HMDB0003339
xref: Reference/PubChem-compound 23327
xref: Reference/BioCyc GAMMA-GLUTAMYL-D-GLUTAMATE
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C001849

Reference/CAS 3616-42-0
type: UnificationXref
id: 3616-42-0
db: CAS

UDP-N-acetyl-α-D-muramate
type: SmallMolecule
entity reference: UDP-N-acetyl-α-D-muramate

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

ChemicalStructure/PW C001906
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate
type: SmallMolecule
entity reference: UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

ChemicalStructure/PW C001900
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](N)C(=O)N[C@H](C)C(O)=O

Reference/PubChem-compound 25244658
type: UnificationXref
id: 25244658
db: PubChem-compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Compound/PW C001900/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Alanyl-D-alanine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

ChemicalStructure/PW C042617
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/COP(O)(O)=O

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

TransportCatalysis845
type: Catalysis
controller: Unknown
controlled: Transport949
control type: ACTIVATION

Compound/PW C041115/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-α-D-muramate
stoichiometric coefficient: 1.0

Compound/PW C042617/Stoichiometry/1.0
type: Stoichiometry
physical entity: di-trans,octa-cis-undecaprenyl phosphate
stoichiometric coefficient: 1.0

TransportCatalysis842
type: Catalysis
controller: Unknown
controlled: Transport946
control type: ACTIVATION

Reference/ChEBI CHEBI 61388
type: UnificationXref
id: CHEBI:61388
db: ChEBI

Compound/PW C000201 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q02G12
type: UnificationXref
id: Q02G12
db: UniProt

Reference/ChEBI CHEBI 61386
type: UnificationXref
id: CHEBI:61386
db: ChEBI

Reference/ChEBI CHEBI 61387
type: UnificationXref
id: CHEBI:61387
db: ChEBI

Hydrogen ion
type: SmallMolecule
entity reference: Hydrogen ion

UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28639
xref: Reference/PubChem-compound 23724481
chemical formula: C35H55N7O26P2
molecular weight: 1051.2672
structure: ChemicalStructure/PW C041232

β-D-fructofuranose
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 42560
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C041111

6.3.2.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040829/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040841/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041232/Stoichiometry/1.0
right: Adenosine diphosphate
right: UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.2.13
left: meso-diaminopimelate
left: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
left: Adenosine triphosphate
name: Adenosine triphosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-diaminopimelate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate
conversion direction: LEFT_TO_RIGHT

Glycolysis and Pyruvate Dehydrogenase
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway111359
pathway component: SubPathwayInteraction111359
xref: Reference/PathWhiz PW000785
xref: Reference/SMPDB SMP0000807
name: SubPathway

UDP-N-acetyl-α-D-glucosamine-enolpyruvate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 68483
chemical formula: C20H26N3O19P2
molecular weight: 674.06525
structure: ChemicalStructure/PW C041114

Reaction183667
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040941/Stoichiometry/1.0
right: β-D-fructofuranose 6-phosphate
spontaneous: false
left: β-D-Glucose 6-phosphate
name: β-D-Glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 388538
type: UnificationXref
id: 388538
db: ChemSpider

UDP-N-acetyl-α-D-muramate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 70757
chemical formula: C20H28N3O19P2
molecular weight: 676.0809
structure: ChemicalStructure/PW C041115

6.3.2.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041115/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040828/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: UDP-N-acetylmuramoyl-L-alanine
right: Phosphate
spontaneous: false
EC number: 6.3.2.8
left: UDP-N-acetyl-α-D-muramate
left: L-Alanine
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Alanine + UDP-N-acetyl-α-D-muramate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-acetylmuramoyl-L-alanine
conversion direction: LEFT_TO_RIGHT

D-Glutamic acid
type: SmallMolecule
entity reference: D-Glutamic acid

Reference/KEGG Compound C00133
type: UnificationXref
id: C00133
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Glucosamine 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 3616-42-0
xref: Reference/ChemSpider 388356
xref: Reference/ChEBI CHEBI 15873
xref: Reference/KEGG Compound C00352
xref: Reference/BioCyc D-GLUCOSAMINE-6-P
xref: Reference/PubChem-compound 439217
xref: Reference/HMDB HMDB0001254
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000969

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

ReactionCoupledTransportCatalysis390
type: Catalysis
controller: mannose PTS permease
controlled: ReactionCoupledTransport353
control type: ACTIVATION

Reference/ChEBI CHEBI 7125
type: UnificationXref
id: CHEBI:7125
db: ChEBI

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/BioCyc D-GLUCOSAMINE-6-P
type: UnificationXref
id: D-GLUCOSAMINE-6-P
db: BioCyc

Reference/UniProt Q02FS3
type: UnificationXref
id: Q02FS3
db: UniProt

Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04582
xref: Reference/PubChem-compound 25245499
xref: Reference/ChEBI CHEBI 61387
chemical formula: C87H139N7O23P2
molecular weight: 1711.9419
structure: ChemicalStructure/PW C041243

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
type: Complex
component stoichiometry: Protein/12075/Stoichiometry/3.0
component: Bifunctional protein GlmU

Glucosamine-1P
type: SmallMolecule
entity reference: Glucosamine-1P

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Compound/PW C000458 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

D-fructose-6-phosphate aminotransferase
type: Complex
component stoichiometry: Protein/11860/Stoichiometry/2.0
component: Unknown

Reference/CAS 338-69-2
type: UnificationXref
id: 338-69-2
db: CAS

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChemSpider 4573916
type: UnificationXref
id: 4573916
db: ChemSpider

TransportCatalysis822
type: Catalysis
controller: Unknown
controlled: Transport924
control type: ACTIVATION

Reference/PubChem-compound 23327
type: UnificationXref
id: 23327
db: PubChem-compound

TransportCatalysis821
type: Catalysis
controller: C4-dicarboxylate transport protein 1
controlled: Transport923
control type: ACTIVATION

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

ChemicalStructure/PW C042921
type: ChemicalStructure
structure format: SMILES

6.3.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001009/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001900/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: D-Alanyl-D-alanine
right: Phosphate
spontaneous: false
EC number: 6.3.2.4
left: D-Alanine
left: Adenosine triphosphate
name: Adenosine triphosphate + 2 D-Alanine → Adenosine diphosphate + D-Alanyl-D-alanine + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C042922
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-1-P
db: BioCyc

Reference/SMPDB SMP0000807
type: UnificationXref
id: SMP0000807
db: SMPDB

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/KEGG Compound C03543
type: UnificationXref
id: C03543
db: KEGG Compound

L-Alanine
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Alanine

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Reference/HMDB HMDB0001469
type: UnificationXref
id: HMDB0001469
db: HMDB

Compound/Generic221/Stoichiometry/1.0
type: Stoichiometry
physical entity: a peptidoglycan with D,D cross-links (meso-diaminopimelate containing)
stoichiometric coefficient: 1.0

TransportCatalysis877
type: Catalysis
controller: Unknown
controlled: Transport987
control type: ACTIVATION

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/PubChem-compound 5460362
type: UnificationXref
id: 5460362
db: PubChem-compound

Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

Peptidoglycan Biosynthesis I
type: Pathway
pathway order: PathwayEnzymeReaction/2157150
pathway order: PathwayEnzymeReaction/2157151
pathway order: PathwayTransport/2157175
pathway order: PathwayEnzymeReaction/2157152
pathway order: PathwayTransport/2157176
pathway order: PathwayEnzymeReaction/2157170
pathway order: PathwayEnzymeReaction/2157157
pathway order: PathwayEnzymeReaction/2157158
pathway order: PathwayEnzymeReaction/2157159
pathway order: PathwayEnzymeReaction/2157153
pathway order: PathwaySubPathway/111359
pathway order: PathwayEnzymeReaction/2157154
pathway order: PathwayEnzymeReaction/2157155
pathway order: PathwayEnzymeReaction/2157156
pathway order: PathwayEnzymeReaction/2157160
pathway order: PathwayEnzymeReaction/2157161
pathway order: PathwayEnzymeReaction/2157162
pathway order: PathwayEnzymeReaction/2157163
pathway order: PathwayEnzymeReaction/2157168
pathway order: PathwayEnzymeReaction/2157147
pathway order: PathwayEnzymeReaction/2157169
pathway order: PathwayEnzymeReaction/2157148
pathway order: PathwayEnzymeReaction/2157149
pathway order: PathwayEnzymeReaction/2157164
pathway order: PathwayTransport/2157173
pathway order: PathwayEnzymeReaction/2157165
pathway order: PathwayTransport/2157174
pathway order: PathwayEnzymeReaction/2157166
pathway order: PathwayTransport/2157171
pathway order: PathwayEnzymeReaction/2157167
pathway order: PathwayTransport/2157172
pathway component: 1.3.1.98
pathway component: 6.3.2.4
pathway component: 2.5.1.7
pathway component: ReactionCatalysis173429
pathway component: ReactionCatalysis173428
pathway component: ReactionCatalysis173430
pathway component: TransportCatalysis877
pathway component: 2.6.1.16
pathway component: ReactionCoupledTransport353
pathway component: Transport1004
pathway component: ReactionCatalysis173487
pathway component: ReactionCatalysis173486
pathway component: ReactionCatalysis173485
pathway component: ReactionCatalysis173484
pathway component: Transport924
pathway component: ReactionCatalysis173489
pathway component: ReactionCatalysis173125
pathway component: ReactionCatalysis173488
pathway component: TransportCatalysis845
pathway component: 2.4.1.227
pathway component: 2.4.2.-
pathway component: Transport923
pathway component: TransportCatalysis842
pathway component: Reaction183673
pathway component: ReactionCatalysis173483
pathway component: 6.3.2.10
pathway component: 2.7.8.13
pathway component: 6.3.2.13
pathway component: Glycolysis and Pyruvate Dehydrogenase
pathway component: Reaction183667
pathway component: 6.3.2.8
pathway component: ReactionCatalysis173129
pathway component: ReactionCoupledTransportCatalysis390
pathway component: ReactionCatalysis173133
pathway component: ReactionCatalysis173496
pathway component: ReactionCatalysis173495
pathway component: ReactionCatalysis173455
pathway component: ReactionCatalysis173490
pathway component: ReactionCatalysis173494
pathway component: ReactionCatalysis173493
pathway component: ReactionCatalysis173492
pathway component: TransportCatalysis893
pathway component: ReactionCatalysis173491
pathway component: 2.7.7.23
pathway component: Reaction183615
pathway component: 5.4.2.10
pathway component: 5.1.1.3
pathway component: ReactionCatalysis173462

Reference/HMDB HMDB0001109
type: UnificationXref
id: HMDB0001109
db: HMDB

Reference/KEGG Compound C00043
type: UnificationXref
id: C00043
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-97-9
type: UnificationXref
id: 58-97-9
db: CAS

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

2.4.1.227
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041243 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042922 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Uridine 5'-diphosphate
right: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
spontaneous: false
EC number: 2.4.1.227
left: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
left: Uridine diphosphate-N-acetylglucosamine
name: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + Uridine diphosphate-N-acetylglucosamine → Hydrogen Ion + Uridine 5'-diphosphate + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
conversion direction: LEFT_TO_RIGHT

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

2.4.2.-
type: BiochemicalReaction
participant stoichiometry: Compound/Generic220/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042922/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001130/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Undecaprenyl diphosphate
right: Hydrogen Ion
right: a peptidoglycan dimer (meso-diaminopimelate containing)
spontaneous: false
EC number: 2.4.2.-
left: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
name: 2 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine → a peptidoglycan dimer (meso-diaminopimelate containing) + Hydrogen Ion + Undecaprenyl diphosphate
conversion direction: LEFT_TO_RIGHT

Reaction183673
type: BiochemicalReaction
participant stoichiometry: Compound/Generic220/Stoichiometry/1.0
participant stoichiometry: Compound/Generic221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001009/Stoichiometry/1.0
right: a peptidoglycan with D,D cross-links (meso-diaminopimelate containing)
right: D-Alanine
spontaneous: false
left: a peptidoglycan dimer (meso-diaminopimelate containing)
name: a peptidoglycan dimer (meso-diaminopimelate containing) → D-Alanine + a peptidoglycan with D,D cross-links (meso-diaminopimelate containing)
conversion direction: LEFT_TO_RIGHT

6.3.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001900/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041232/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.2.10
left: UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate
left: D-Alanyl-D-alanine
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Alanyl-D-alanine + UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
conversion direction: LEFT_TO_RIGHT

2.7.8.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042617/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041243/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042921/Stoichiometry/1.0
right: Uridine 5'-monophosphate
right: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
spontaneous: false
EC number: 2.7.8.13
left: UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
left: di-trans,octa-cis-undecaprenyl phosphate
name: UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate → Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/ChEBI CHEBI 70757
type: UnificationXref
id: CHEBI:70757
db: ChEBI

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Reference/ChEBI CHEBI 17047
type: UnificationXref
id: CHEBI:17047
db: ChEBI

Reference/HMDB HMDB0001367
type: UnificationXref
id: HMDB0001367
db: HMDB

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Compound/PW C000192/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 57791
type: UnificationXref
id: CHEBI:57791
db: ChEBI

5.1.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001849 Cytosol/Stoichiometry/1.0
right: D-Glutamic acid
spontaneous: false
EC number: 5.1.1.3
left: L-Glutamic acid
name: L-Glutamic acid ↔ D-Glutamic acid
conversion direction: REVERSIBLE

Reference/PubChem-compound 445675
type: UnificationXref
id: 445675
db: PubChem-compound

ChemicalStructure/PW C001009
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](N)C(O)=O

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/CAS 6866-69-9
type: UnificationXref
id: 6866-69-9
db: CAS

UDP-N-acetylglucosamine 1-carboxyvinyltransferase
type: Protein
entity reference: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Reference/PubChem-compound 3960
type: UnificationXref
id: 3960
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Glutamic acid

Reference/HMDB HMDB0000288
type: UnificationXref
id: HMDB0000288
db: HMDB

ChemicalStructure/PW C001130
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Reference/PubChem-compound 71080
type: UnificationXref
id: 71080
db: PubChem-compound

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

6.3.2.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040829/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040828/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001849/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
right: Phosphate
spontaneous: false
EC number: 6.3.2.9
left: D-Glutamic acid
left: UDP-N-acetylmuramoyl-L-alanine
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Glutamic acid + UDP-N-acetylmuramoyl-L-alanine → Adenosine diphosphate + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001254
type: UnificationXref
id: HMDB0001254
db: HMDB

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

D-Alanine
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: D-Alanine

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

ChemicalStructure/PW C040941
type: ChemicalStructure
structure format: SMILES
structure data: OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

L-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Alanine

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Phosphate
type: SmallMolecule
entity reference: Phosphate

ChemicalStructure/PW C040829
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040828
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Reference/PubChem-compound 9965052
type: UnificationXref
id: 9965052
db: PubChem-compound

Compound/PW C000105/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Compound/PW C041026/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01172
type: UnificationXref
id: C01172
db: KEGG Compound

Compound/PW C042922 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000290
type: UnificationXref
id: HMDB0000290
db: HMDB

Pseudomonas aeruginosa
type: BioSource
xref: Reference/TAXONOMY 287

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/ChemSpider 5808
type: UnificationXref
id: 5808
db: ChemSpider

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Transport1004
type: Transport
participant stoichiometry: Compound/PW C042922 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042922 Periplasmic Space/Stoichiometry/1.0
right: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
spontaneous: false
left: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
name: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine (→) Transport: Pseudomonas aeruginosa, Cytosol to Pseudomonas aeruginosa, Periplasmic Space
conversion direction: LEFT_TO_RIGHT

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/PubChem-compound 52940208
type: UnificationXref
id: 52940208
db: PubChem-compound

Bifunctional protein GlmU
type: Protein
entity reference: Bifunctional protein GlmU

Phosphoglucosamine mutase
type: Protein
entity reference: Phosphoglucosamine mutase

Compound/PW C040941 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-fructofuranose 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 21814
type: UnificationXref
id: 21814
db: ChemSpider

Reference/HMDB HMDB0003459
type: UnificationXref
id: HMDB0003459
db: HMDB

Reference/HMDB HMDB0003339
type: UnificationXref
id: HMDB0003339
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine diphosphate-N-acetylglucosamine

ChemicalStructure/PW C040841
type: ChemicalStructure
structure format: SMILES

mannose PTS permease
type: Complex
component stoichiometry: Protein/11860 Inner Membrane/Stoichiometry/2.0
cellular location: Inner Membrane
component: Unknown

UDP-N-acetylmuramate-alanine ligase
type: Complex
component stoichiometry: Protein/12119/Stoichiometry/2.0
component: UDP-N-acetylmuramate--L-alanine ligase

Reference/KEGG Compound C04582
type: UnificationXref
id: C04582
db: KEGG Compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

ChemicalStructure/PW C000196
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 25245499
type: UnificationXref
id: 25245499
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Glucose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt A6VCI8

Reference/PubChem-compound 23724481
type: UnificationXref
id: 23724481
db: PubChem-compound

ChemicalStructure/PW C000194
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Unknown
type: Protein
cellular location: Inner Membrane
entity reference: Unknown

TransportCatalysis893
type: Catalysis
controller: Unknown
controlled: Transport1004
control type: ACTIVATION

Reference/TAXONOMY 287
type: UnificationXref
id: 287
db: TAXONOMY

Compound/Generic220/Stoichiometry/1.0
type: Stoichiometry
physical entity: a peptidoglycan dimer (meso-diaminopimelate containing)
stoichiometric coefficient: 1.0

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/BioCyc UMP
type: UnificationXref
id: UMP
db: BioCyc

L-Alanine
type: SmallMolecule
entity reference: L-Alanine

Reference/ChEBI CHEBI 57634
type: UnificationXref
id: CHEBI:57634
db: ChEBI

Compound/PW C042922 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001055
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

a peptidoglycan dimer (meso-diaminopimelate containing)
type: SmallMoleculeReference

a peptidoglycan with D,D cross-links (meso-diaminopimelate containing)
type: SmallMoleculeReference

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChEBI CHEBI 16932
type: UnificationXref
id: CHEBI:16932
db: ChEBI

meso-diaminopimelate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57791
chemical formula: C7H14N2O4
molecular weight: 190.09535
structure: ChemicalStructure/PW C040841

Reference/ChEBI CHEBI 15966
type: UnificationXref
id: CHEBI:15966
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

ReactionCatalysis173429
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: 2.7.7.23
control type: ACTIVATION

ReactionCatalysis173428
type: Catalysis
controller: Phosphoglucosamine mutase
controlled: 5.4.2.10
control type: ACTIVATION

ReactionCatalysis173430
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: Reaction183615
control type: ACTIVATION

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/BioCyc GAMMA-GLUTAMYL-D-GLUTAMATE
type: UnificationXref
id: GAMMA-GLUTAMYL-D-GLUTAMATE
db: BioCyc

UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMolecule
entity reference: UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

Bifunctional protein GlmU
type: ProteinReference
xref: Reference/UniProt A6VF30

SubPathwayInteraction111359
type: Interaction
name: SubPathwayReaction
name: SubPathway111359Reaction
participant: β-D-fructofuranose 6-phosphate

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Phosphoglucosamine mutase
type: ProteinReference
xref: Reference/UniProt Q02FS3

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

D-Alanine
type: SmallMoleculeReference
xref: Reference/BioCyc D-ALANINE
xref: Reference/HMDB HMDB0001310
xref: Reference/ChemSpider 64234
xref: Reference/KEGG Compound C00133
xref: Reference/PubChem-compound 71080
xref: Reference/CAS 338-69-2
xref: Reference/ChEBI CHEBI 15570
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C001009

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMolecule
entity reference: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

Undecaprenyl diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001469
xref: Reference/CAS 31867-59-1
xref: Reference/ChemSpider 4444213
xref: Reference/BioCyc UNDECAPRENYL-DIPHOSPHATE
xref: Reference/PubChem-compound 5280604
xref: Reference/ChEBI CHEBI 17047
xref: Reference/KEGG Compound C03543
chemical formula: C55H92O7P2
molecular weight: 926.63184
structure: ChemicalStructure/PW C001130

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 528-04-1
type: UnificationXref
id: 528-04-1
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Compound/PW C000180/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 64234
type: UnificationXref
id: 64234
db: ChemSpider

Transport924
type: Transport
participant stoichiometry: Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Glutamic acid
spontaneous: false
left: Sodium
left: L-Glutamic acid
name: L-Glutamic acid (→), Sodium (→) Transport: Pseudomonas aeruginosa, Periplasmic Space to Pseudomonas aeruginosa, Cytosol
conversion direction: LEFT_TO_RIGHT

Undecaprenyl diphosphate
type: SmallMolecule
entity reference: Undecaprenyl diphosphate

Transport923
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Glutamic acid
spontaneous: false
left: Hydrogen Ion
left: L-Glutamic acid
name: Hydrogen Ion (→), L-Glutamic acid (→) Transport: Pseudomonas aeruginosa, Periplasmic Space to Pseudomonas aeruginosa, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

UDP-N-acetylglucosamine 1-carboxyvinyltransferase
type: ProteinReference
xref: Reference/UniProt A6VBC3

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 52940208
xref: Reference/ChEBI CHEBI 61388
chemical formula: C95H152N8O28P2
molecular weight: 1915.0192
structure: ChemicalStructure/PW C042922

UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25244658
xref: Reference/ChEBI CHEBI 61386
chemical formula: C41H61N9O28P2
molecular weight: 1189.3124
structure: ChemicalStructure/PW C042921

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

D-Alanine
type: SmallMolecule
entity reference: D-Alanine

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: Protein
cellular location: Cytosol
entity reference: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04256
type: UnificationXref
id: C04256
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ReactionCatalysis173455
type: Catalysis
controller: D-fructose-6-phosphate aminotransferase
controlled: 2.6.1.16
control type: ACTIVATION

Reference/UniProt A6VB88
type: UnificationXref
id: A6VB88
db: UniProt

Compound/PW C001849/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glutamic acid
stoichiometric coefficient: 1.0

Reference/UniProt A6VB84
type: UnificationXref
id: A6VB84
db: UniProt

Reference/ChemSpider 393240
type: UnificationXref
id: 393240
db: ChemSpider

Compound/PW C041232/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-Acetylmuramoyl-L-alanyl-D-γ-glutamyl-meso-2,6-diaminopimelate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

ReactionCatalysis173462
type: Catalysis
controller: Unknown
controlled: 1.3.1.98
control type: ACTIVATION

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Transport946
type: Transport
participant stoichiometry: Compound/PW C001009 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001009 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
right: D-Alanine
right: Hydrogen Ion
spontaneous: false
left: D-Alanine
left: Hydrogen Ion
name: D-Alanine (→), Hydrogen Ion (→) Transport: Pseudomonas aeruginosa, Periplasmic Space to Pseudomonas aeruginosa, Cytosol
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMolecule
entity reference: NADP

Transport949
type: Transport
participant stoichiometry: Compound/PW C042922 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042922 Periplasmic Space/Stoichiometry/1.0
right: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
spontaneous: false
left: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
name: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine (→) Transport: Pseudomonas aeruginosa, Cytosol to Pseudomonas aeruginosa, Periplasmic Space
conversion direction: LEFT_TO_RIGHT

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

ReactionCatalysis173461
type: Catalysis
controller: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
controlled: 2.5.1.7
control type: ACTIVATION

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/PathWhiz PW000785
type: UnificationXref
id: PW000785
db: PathWhiz

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

D-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glutamic acid

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
type: SmallMolecule
entity reference: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

a peptidoglycan with D,D cross-links (meso-diaminopimelate containing)
type: SmallMolecule
entity reference: a peptidoglycan with D,D cross-links (meso-diaminopimelate containing)

Uridine diphosphate-N-acetylglucosamine
type: SmallMoleculeReference
xref: Reference/CAS 528-04-1
xref: Reference/PubChem-compound 445675
xref: Reference/HMDB HMDB0000290
xref: Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
xref: Reference/KEGG Compound C00043
xref: Reference/ChEBI CHEBI 16264
xref: Reference/ChemSpider 393240
chemical formula: C17H27N3O17P2
molecular weight: 607.08154
structure: ChemicalStructure/PW C000196

Uridine 5'-monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000288
xref: Reference/CAS 58-97-9
xref: Reference/KEGG Compound C00105
xref: Reference/PubChem-compound 6030
xref: Reference/BioCyc UMP
xref: Reference/ChEBI CHEBI 16695
xref: Reference/ChemSpider 5808
chemical formula: C9H13N2O9P
molecular weight: 324.03586
structure: ChemicalStructure/PW C000194

a peptidoglycan dimer (meso-diaminopimelate containing)
type: SmallMolecule
entity reference: a peptidoglycan dimer (meso-diaminopimelate containing)

Reference/BioCyc D-ALANINE
type: UnificationXref
id: D-ALANINE
db: BioCyc

β-D-fructofuranose 6-phosphate
type: SmallMolecule
entity reference: β-D-fructofuranose 6-phosphate

Glutamate racemase
type: Protein
cellular location: Cytosol
entity reference: Glutamate racemase

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

UDP-N-acetylmuramoyl-L-alanine
type: SmallMolecule
entity reference: UDP-N-acetylmuramoyl-L-alanine

Compound/PW C040841/Stoichiometry/1.0
type: Stoichiometry
physical entity: meso-diaminopimelate
stoichiometric coefficient: 1.0

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

N-Acetyl-glucosamine 1-phosphate
type: SmallMolecule
entity reference: N-Acetyl-glucosamine 1-phosphate

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis173487
type: Catalysis
controller: Phospho-N-acetylmuramoyl-pentapeptide-transferase
controlled: 2.7.8.13
control type: ACTIVATION

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ReactionCatalysis173486
type: Catalysis
controller: Unknown
controlled: 6.3.2.10
control type: ACTIVATION

Reference/HMDB HMDB0001310
type: UnificationXref
id: HMDB0001310
db: HMDB

ReactionCatalysis173485
type: Catalysis
controller: Unknown
controlled: 6.3.2.13
control type: ACTIVATION

N-Acetyl-glucosamine 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 7125
xref: Reference/ChemSpider 389248
xref: Reference/HMDB HMDB0001367
xref: Reference/PubChem-compound 440272
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
xref: Reference/CAS 6866-69-9
xref: Reference/KEGG Compound C04256
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C001055

ReactionCatalysis173484
type: Catalysis
controller: UDP-N-acetylmuramate-alanine ligase
controlled: 6.3.2.8
control type: ACTIVATION

Compound/PW C040941/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-fructofuranose 6-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

ReactionCatalysis173489
type: Catalysis
controller: penicillin-binding protein 1B
controlled: 2.4.2.-
control type: ACTIVATION

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

ReactionCatalysis173125
type: Catalysis
controller: D-alanine ligase
controlled: 6.3.2.4
control type: ACTIVATION

ReactionCatalysis173488
type: Catalysis
controller: penicillin-binding protein 1A
controlled: 2.4.2.-
control type: ACTIVATION

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/SMPDB SMP0121305
type: UnificationXref
id: SMP0121305
db: SMPDB

ReactionCatalysis173483
type: Catalysis
controller: phosphoglucose isomerase
controlled: Reaction183667
control type: ACTIVATION

phosphoglucose isomerase
type: Complex
component stoichiometry: Protein/11911/Stoichiometry/2.0
component: Glucose-6-phosphate isomerase

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

β-D-fructofuranose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57634
chemical formula: C6H11O9P
molecular weight: 258.01517
structure: ChemicalStructure/PW C040941

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

ReactionCatalysis173129
type: Catalysis
controller: Unknown
controlled: 6.3.2.9
control type: ACTIVATION

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Compound/PW C042921/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
stoichiometric coefficient: 1.0

UDP-N-acetylmuramoyl-L-alanine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16932
chemical formula: C23H36N4O20P2
molecular weight: 750.13983
structure: ChemicalStructure/PW C040828

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3960
chemical formula: C22H32Cl2N2O4
molecular weight: 458.17392
structure: ChemicalStructure/PW C040829

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
entity reference: Uridine diphosphate-N-acetylglucosamine

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

Uridine 5'-monophosphate
type: SmallMolecule
entity reference: Uridine 5'-monophosphate

ReactionCatalysis173133
type: Catalysis
controller: Glutamate racemase
controlled: 5.1.1.3
control type: ACTIVATION

ReactionCatalysis173496
type: Catalysis
controller: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
controlled: 2.4.1.227
control type: ACTIVATION

ReactionCatalysis173495
type: Catalysis
controller: Unknown
controlled: Reaction183673
control type: ACTIVATION

Reference/ChEBI CHEBI 68483
type: UnificationXref
id: CHEBI:68483
db: ChEBI

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C041243 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
stoichiometric coefficient: 1.0

ReactionCatalysis173490
type: Catalysis
controller: Unknown
controlled: 2.4.2.-
control type: ACTIVATION

Compound/PW C001055/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-glucosamine 1-phosphate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Uridine triphosphate
type: SmallMolecule
entity reference: Uridine triphosphate

ReactionCatalysis173494
type: Catalysis
controller: penicillin-binding protein 1A
controlled: Reaction183673
control type: ACTIVATION

ReactionCatalysis173493
type: Catalysis
controller: penicillin-binding protein 1B
controlled: Reaction183673
control type: ACTIVATION

ReactionCatalysis173492
type: Catalysis
controller: Unknown
controlled: Reaction183673
control type: ACTIVATION

ReactionCatalysis173491
type: Catalysis
controller: Unknown
controlled: 2.4.2.-
control type: ACTIVATION

meso-diaminopimelate
type: SmallMolecule
entity reference: meso-diaminopimelate

Reference/ChEBI CHEBI 15873
type: UnificationXref
id: CHEBI:15873
db: ChEBI

Compound/PW C000105 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Glucose-6-phosphate isomerase
type: Protein
entity reference: Glucose-6-phosphate isomerase

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Transport987
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Alanine
spontaneous: false
left: L-Alanine
left: Hydrogen Ion
name: L-Alanine (→), Hydrogen Ion (→) Transport: Pseudomonas aeruginosa, Periplasmic Space to Pseudomonas aeruginosa, Cytosol
conversion direction: LEFT_TO_RIGHT

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid

Compound/PW C001009 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Alanine
stoichiometric coefficient: 1.0

Compound/PW C000194/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28639
type: UnificationXref
id: CHEBI:28639
db: ChEBI

Reference/UniProt A6VBC3
type: UnificationXref
id: A6VBC3
db: UniProt

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000969
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/CAS 6893-26-1
type: UnificationXref
id: 6893-26-1
db: CAS

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C042922/Stoichiometry/2.0
type: Stoichiometry
physical entity: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
stoichiometric coefficient: 2.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChEBI CHEBI 15570
type: UnificationXref
id: CHEBI:15570
db: ChEBI

β-D-fructofuranose 6-phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: β-D-fructofuranose 6-phosphate

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Compound/PW C000196/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Compound/PW C000105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

UDP-N-acetylmuramate--L-alanine ligase
type: ProteinReference
xref: Reference/UniProt A6VB84

Reference/PubChem-compound 439427
type: UnificationXref
id: 439427
db: PubChem-compound

Compound/PW C000196 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: Reference/UniProt B7UZJ0
organism: Pseudomonas aeruginosa

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Phospho-N-acetylmuramoyl-pentapeptide-transferase
type: ProteinReference
xref: Reference/UniProt A6VB88

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

β-D-fructofuranose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-fructofuranose 6-phosphate
name: SubPathwayInput

Protein/12075/Stoichiometry/3.0
type: Stoichiometry
physical entity: Bifunctional protein GlmU
stoichiometric coefficient: 3.0

Compound/PW C040828/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17719
type: UnificationXref
id: CHEBI:17719
db: ChEBI

Reference/PubChem-compound 439217
type: UnificationXref
id: 439217
db: PubChem-compound

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

penicillin-binding protein 1B
type: Complex
component stoichiometry: Protein/11860/Stoichiometry/2.0
component: Unknown

Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
type: UnificationXref
id: UDP-N-ACETYL-D-GLUCOSAMINE
db: BioCyc

penicillin-binding protein 1A
type: Complex
component stoichiometry: Protein/11860/Stoichiometry/2.0
component: Unknown

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 923-16-0
type: UnificationXref
id: 923-16-0
db: CAS

ChemicalStructure/PW C041115
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16576
type: UnificationXref
id: CHEBI:16576
db: ChEBI

ChemicalStructure/PW C041114
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 389248
type: UnificationXref
id: 389248
db: ChemSpider

Compound/PW C000969/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

β-D-Glucose 6-phosphate
type: SmallMolecule
entity reference: β-D-Glucose 6-phosphate

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/UniProt A6VCI8
type: UnificationXref
id: A6VCI8
db: UniProt

D-Alanyl-D-alanine
type: SmallMolecule
entity reference: D-Alanyl-D-alanine

Compound/PW C041243/Stoichiometry/1.0
type: Stoichiometry
physical entity: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
stoichiometric coefficient: 1.0

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00993
type: UnificationXref
id: C00993
db: KEGG Compound

Reference/ChEBI CHEBI 16695
type: UnificationXref
id: CHEBI:16695
db: ChEBI

di-trans,octa-cis-undecaprenyl phosphate
type: SmallMolecule
entity reference: di-trans,octa-cis-undecaprenyl phosphate

Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Protein/11860/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

ChemicalStructure/PW C041243
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5280604
type: UnificationXref
id: 5280604
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Sodium

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

C4-dicarboxylate transport protein 1
type: Protein
entity reference: C4-dicarboxylate transport protein 1

Reference/UniProt Q02UV9
type: UnificationXref
id: Q02UV9
db: UniProt

D-alanine ligase
type: Complex
component: Unknown

Protein/11860 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444213
type: UnificationXref
id: 4444213
db: ChemSpider

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

ChemicalStructure/PW C000868
type: ChemicalStructure
structure format: SMILES

Compound/PW C001130/Stoichiometry/1.0
type: Stoichiometry
physical entity: Undecaprenyl diphosphate
stoichiometric coefficient: 1.0

Protein/11911/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucose-6-phosphate isomerase
stoichiometric coefficient: 2.0

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ChemicalStructure/PW C041026
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Compound/PW C040829/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

Reference/BioCyc UNDECAPRENYL-DIPHOSPHATE
type: UnificationXref
id: UNDECAPRENYL-DIPHOSPHATE
db: BioCyc

Reference/BioCyc D-ALA-D-ALA
type: UnificationXref
id: D-ALA-D-ALA
db: BioCyc

di-trans,octa-cis-undecaprenyl phosphate
type: SmallMoleculeReference
chemical formula: C55H91O4P
molecular weight: 846.6655
structure: ChemicalStructure/PW C042617

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

ChemicalStructure/PW C001849
type: ChemicalStructure
structure format: SMILES
structure data: N[C@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS