Reference/PubChem-compound 11970
type: UnificationXref
id: 11970
db: PubChem-compound

Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Tetrahydropteridine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05650
xref: Reference/HMDB HMDB0001216
xref: Reference/BioCyc 5678-TETRAHYDROPTERIDINE
xref: Reference/ChEBI CHEBI 28889
xref: Reference/CAS 10593-78-9
xref: Reference/ChemSpider 151
xref: Reference/PubChem-compound 156
chemical formula: C6H8N4
molecular weight: 136.07489
structure: ChemicalStructure/PW C000945

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/PubChem-compound 6140
type: UnificationXref
id: 6140
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/CAS 63-91-2
type: UnificationXref
id: 63-91-2
db: CAS

Reference/SMPDB SMP0122609
type: UnificationXref
id: SMP0122609
db: SMPDB

NADH
type: SmallMolecule
entity reference: NADH

Reference/KEGG Compound C05332
type: UnificationXref
id: C05332
db: KEGG Compound

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Tyrosine aminotransferase
type: Protein
entity reference: Tyrosine aminotransferase

Glutamate oxaloacetate transaminase 1, isoform A
type: Protein
entity reference: Glutamate oxaloacetate transaminase 1, isoform A

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

NAD
type: SmallMolecule
entity reference: NAD

Reference/PubChem-compound 1001
type: UnificationXref
id: 1001
db: PubChem-compound

Reference/ChEBI CHEBI 28478
type: UnificationXref
id: CHEBI:28478
db: ChEBI

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Compound/PW C002680 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylacetaldehyde
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Ammonia

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/KEGG Compound C07086
type: UnificationXref
id: C07086
db: KEGG Compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChemSpider 13876539
type: UnificationXref
id: 13876539
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/HMDB HMDB0000669
type: UnificationXref
id: HMDB0000669
db: HMDB

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ReactionCatalysis202297
type: Catalysis
controller: AT01267p
controlled: 1.-.-.-
control type: ACTIVATION

ReactionCatalysis202298
type: Catalysis
controller: 4-hydroxyphenylpyruvate dioxygenase
controlled: Reaction212671
control type: ACTIVATION

ReactionCatalysis202299
type: Catalysis
controller: Aldehyde dehydrogenase
controlled: Reaction212672
control type: ACTIVATION

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

ReactionCatalysis202293
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Phenylacetic acid
type: SmallMoleculeReference
xref: Reference/BioCyc PHENYLACETATE
xref: Reference/PubChem-compound 999
xref: Reference/ChEBI CHEBI 30745
xref: Reference/KEGG Compound C07086
xref: Reference/HMDB HMDB0000209
xref: Reference/CAS 103-82-2
xref: Reference/ChemSpider 10181341
chemical formula: C8H8O2
molecular weight: 136.05243
structure: ChemicalStructure/PW C000135

Reference/ChemSpider 151
type: UnificationXref
id: 151
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Reference/BioCyc HYDRPHENYLAC-CPD
type: UnificationXref
id: HYDRPHENYLAC-CPD
db: BioCyc

Phenylpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 156-06-9
xref: Reference/ChEBI CHEBI 30851
xref: Reference/ChemSpider 972
xref: Reference/BioCyc PHENYL-PYRUVATE
xref: Reference/PubChem-compound 997
xref: Reference/HMDB HMDB0000205
xref: Reference/KEGG Compound C00166
chemical formula: C9H8O3
molecular weight: 164.04735
structure: ChemicalStructure/PW C000131

Reference/ChemSpider 11476
type: UnificationXref
id: 11476
db: ChemSpider

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/KEGG Compound C22239
type: UnificationXref
id: C22239
db: KEGG Compound

Compound/PW C000104/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Phenylalanine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Tetrahydropteridine
type: SmallMolecule
entity reference: Tetrahydropteridine

Reference/UniProt P05031
type: UnificationXref
id: P05031
db: UniProt

Aldehyde dehydrogenase
type: ProteinReference
organism: BiologicalState579

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

BiologicalState579
type: BioSource
xref: Reference/TAXONOMY 7227
name: Drosophila melanogaster, Liver
tissue: Liver

Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Phenylacetaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00601
xref: Reference/ChEBI CHEBI 16424
xref: Reference/ChemSpider 13876539
xref: Reference/PubChem-compound 998
xref: Reference/HMDB HMDB0006236
xref: Reference/CAS 122-78-1
xref: Reference/BioCyc HYDRPHENYLAC-CPD
chemical formula: C8H8O
molecular weight: 120.05752
structure: ChemicalStructure/PW C002680

AT01267p
type: ProteinReference
xref: Reference/UniProt Q9VCA1
organism: Drosophila melanogaster

4-hydroxyphenylpyruvate dioxygenase
type: ProteinReference
xref: Reference/UniProt Q961W1

Phenylacetaldehyde
type: SmallMolecule
entity reference: Phenylacetaldehyde

Reference/HMDB HMDB0000205
type: UnificationXref
id: HMDB0000205
db: HMDB

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Phenylethylamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05332
xref: Reference/CAS 64-04-0
xref: Reference/BioCyc PHENYLETHYLAMINE
xref: Reference/ChemSpider 13856352
xref: Reference/HMDB HMDB0012275
xref: Reference/ChEBI CHEBI 18397
xref: Reference/PubChem-compound 1001
chemical formula: C8H11N
molecular weight: 121.08915
structure: ChemicalStructure/PW C007816

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/HMDB HMDB0000209
type: UnificationXref
id: HMDB0000209
db: HMDB

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

4a-Hydroxy-5,6,7,8-tetrahydropteridine
type: SmallMolecule
entity reference: 4a-Hydroxy-5,6,7,8-tetrahydropteridine

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C000131
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=O)CC1=CC=CC=C1

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

ChemicalStructure/PW C000135
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CC=CC=C1

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/UniProt Q9VCA1
type: UnificationXref
id: Q9VCA1
db: UniProt

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/PubChem-compound 405226430
type: UnificationXref
id: 405226430
db: PubChem-compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C000945/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydropteridine
stoichiometric coefficient: 1.0

ortho-Hydroxyphenylacetic acid
type: SmallMolecule
entity reference: ortho-Hydroxyphenylacetic acid

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/BioCyc PHENYL-PYRUVATE
type: UnificationXref
id: PHENYL-PYRUVATE
db: BioCyc

Glutamate oxaloacetate transaminase 1, isoform A
type: ProteinReference
xref: Reference/UniProt Q7K221
organism: BiologicalState579

Tyrosine aminotransferase
type: ProteinReference
xref: Reference/UniProt Q9VY42
organism: BiologicalState579

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

ChemicalStructure/PW C002680
type: ChemicalStructure
structure format: SMILES
structure data: O=CCC1=CC=CC=C1

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

ChemicalStructure/PW C000104
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=CC=C1)C(O)=O

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

L-Tyrosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Tyrosine
name: SubPathwayOutput

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Oxygen
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxygen

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/PathWhiz PW123923
type: UnificationXref
id: PW123923
db: PathWhiz

4a-Hydroxy-5,6,7,8-tetrahydropteridine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C22239
xref: Reference/PubChem-compound 405226430
chemical formula: C6H10N4O
molecular weight: 154.08546
structure: ChemicalStructure/PW C108781

Reference/BioCyc PHENYLACETATE
type: UnificationXref
id: PHENYLACETATE
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P05031
organism: BiologicalState579

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C007816 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylethylamine
stoichiometric coefficient: 1.0

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/ChemSpider 13856352
type: UnificationXref
id: 13856352
db: ChemSpider

Phenylethylamine
type: SmallMolecule
entity reference: Phenylethylamine

Reference/CAS 614-75-5
type: UnificationXref
id: 614-75-5
db: CAS

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/HMDB HMDB0001216
type: UnificationXref
id: HMDB0001216
db: HMDB

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000103/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Protein henna
type: Protein
entity reference: Protein henna

Reference/BioCyc 5678-TETRAHYDROPTERIDINE
type: UnificationXref
id: 5678-TETRAHYDROPTERIDINE
db: BioCyc

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18397
type: UnificationXref
id: CHEBI:18397
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

Reference/ChEBI CHEBI 28889
type: UnificationXref
id: CHEBI:28889
db: ChEBI

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/HMDB HMDB0006236
type: UnificationXref
id: HMDB0006236
db: HMDB

SubPathwayInteraction112737
type: Interaction
name: SubPathway112737Reaction
name: SubPathwayReaction
participant: L-Tyrosine

Reference/ChemSpider 10181341
type: UnificationXref
id: 10181341
db: ChemSpider

SubPathwayInteraction112739
type: Interaction
name: SubPathwayReaction
name: SubPathway112739Reaction
participant: ortho-Hydroxyphenylacetic acid

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007816/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
right: Carbon dioxide
right: Phenylethylamine
spontaneous: false
EC number: 4.1.1.28
left: L-Phenylalanine
name: L-Phenylalanine ? Carbon dioxide + Phenylethylamine

Reference/KEGG Compound C00601
type: UnificationXref
id: C00601
db: KEGG Compound

Reference/ChEBI CHEBI 16424
type: UnificationXref
id: CHEBI:16424
db: ChEBI

Reference/PubChem-compound 999
type: UnificationXref
id: 999
db: PubChem-compound

Reference/PubChem-compound 997
type: UnificationXref
id: 997
db: PubChem-compound

Reference/PubChem-compound 998
type: UnificationXref
id: 998
db: PubChem-compound

Reference/KEGG Compound C00166
type: UnificationXref
id: C00166
db: KEGG Compound

Compound/PW C108781/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxy-5,6,7,8-tetrahydropteridine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05852
type: UnificationXref
id: C05852
db: KEGG Compound

Phenylethylamine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phenylethylamine

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/UniProt Q27600
type: UnificationXref
id: Q27600
db: UniProt

Reference/UniProt Q961W1
type: UnificationXref
id: Q961W1
db: UniProt

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/UniProt Q7K221
type: UnificationXref
id: Q7K221
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

ortho-Hydroxyphenylacetic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11970
xref: Reference/ChEBI CHEBI 28478
xref: Reference/HMDB HMDB0000669
xref: Reference/CAS 614-75-5
xref: Reference/ChemSpider 11476
xref: Reference/KEGG Compound C05852
chemical formula: C8H8O3
molecular weight: 152.04735
structure: ChemicalStructure/PW C000526

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 10593-78-9
type: UnificationXref
id: 10593-78-9
db: CAS

1.-.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002680 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007816 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: Phenylacetaldehyde
right: Hydrogen peroxide
spontaneous: false
EC number: 1.-.-.-
left: Phenylethylamine
left: Water
left: Oxygen
name: Oxygen + Phenylethylamine + Water ↔ Ammonia + Hydrogen peroxide + Phenylacetaldehyde
conversion direction: REVERSIBLE

Reaction212671
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000131/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000526/Stoichiometry/1.0
right: Carbon dioxide
right: ortho-Hydroxyphenylacetic acid
spontaneous: false
left: Phenylpyruvic acid
left: Oxygen
name: Oxygen + Phenylpyruvic acid → Carbon dioxide + ortho-Hydroxyphenylacetic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reaction212672
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000135/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002680/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Phenylacetic acid
spontaneous: false
left: Water
left: Phenylacetaldehyde
left: NAD
name: NAD + Phenylacetaldehyde + Water ↔ Hydrogen Ion + NADH + Phenylacetic acid
conversion direction: REVERSIBLE

ChemicalStructure/PW C000945
type: ChemicalStructure
structure format: SMILES
structure data: C1CNC2=C(N1)C=NC=N2

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000159
type: UnificationXref
id: HMDB0000159
db: HMDB

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Aldehyde dehydrogenase
type: Protein
entity reference: Aldehyde dehydrogenase

4-hydroxyphenylpyruvate dioxygenase
type: Protein
entity reference: 4-hydroxyphenylpyruvate dioxygenase

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/CAS 156-06-9
type: UnificationXref
id: 156-06-9
db: CAS

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Reference/CAS 64-04-0
type: UnificationXref
id: 64-04-0
db: CAS

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChEBI CHEBI 17295
type: UnificationXref
id: CHEBI:17295
db: ChEBI

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Compound/PW C002680/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylacetaldehyde
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

SubPathwayInteraction112740
type: Interaction
name: SubPathway112740Reaction
name: SubPathwayReaction
participant: L-Phenylalanine

SubPathwayInteraction112741
type: Interaction
name: SubPathwayReaction
name: SubPathway112741Reaction
participant: L-Phenylalanine

Reference/BioCyc PHE
type: UnificationXref
id: PHE
db: BioCyc

Phenylalanine Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2460540
pathway order: PathwayEnzymeReaction/2460538
pathway order: PathwaySubPathway/112737
pathway order: PathwayEnzymeReaction/2460536
pathway order: PathwaySubPathway/112739
pathway order: PathwayEnzymeReaction/2460537
pathway order: PathwayEnzymeReaction/2460534
pathway order: PathwayEnzymeReaction/2460535
pathway order: PathwayEnzymeReaction/2460488
pathway order: PathwaySubPathway/112740
pathway order: PathwaySubPathway/112741
pathway component: 4.1.1.28
pathway component: 1.14.16.1
pathway component: 2.6.1.1
pathway component: Tyrosine Metabolism
pathway component: Styrene Degradation
pathway component: 1.-.-.-
pathway component: Reaction212671
pathway component: ReactionCatalysis202274
pathway component: ReactionCatalysis202275
pathway component: ReactionCatalysis202297
pathway component: Reaction212672
pathway component: ReactionCatalysis202298
pathway component: ReactionCatalysis202276
pathway component: ReactionCatalysis202299
pathway component: Phenylalanine, Tyrosine and Tryptophan Biosynthesis
pathway component: ReactionCatalysis202293
pathway component: Tyrosine, Piperidine and Pyridine Alkaloid Biosynthesis
xref: Reference/SMPDB SMP0122609
xref: Reference/PathWhiz PW123923
organism: Drosophila melanogaster

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

ortho-Hydroxyphenylacetic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: ortho-Hydroxyphenylacetic acid
name: SubPathwayOutput

Phenylacetaldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phenylacetaldehyde

L-Phenylalanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6140
xref: Reference/HMDB HMDB0000159
xref: Reference/ChemSpider 5910
xref: Reference/ChEBI CHEBI 17295
xref: Reference/BioCyc PHE
xref: Reference/CAS 63-91-2
xref: Reference/KEGG Compound C00079
chemical formula: C9H11NO2
molecular weight: 165.07898
structure: ChemicalStructure/PW C000104

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112737
pathway component: SubPathwayInteraction112737
name: SubPathway

Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Styrene Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112739
pathway component: SubPathwayInteraction112739
name: SubPathway

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Phenylacetic acid
type: SmallMolecule
entity reference: Phenylacetic acid

ReactionCatalysis202274
type: Catalysis
controller: Protein henna
controlled: 1.14.16.1
control type: ACTIVATION

ReactionCatalysis202275
type: Catalysis
controller: Glutamate oxaloacetate transaminase 1, isoform A
controlled: 2.6.1.1
control type: ACTIVATION

ReactionCatalysis202276
type: Catalysis
controller: Tyrosine aminotransferase
controlled: 2.6.1.1
control type: ACTIVATION

Reference/HMDB HMDB0012275
type: UnificationXref
id: HMDB0012275
db: HMDB

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

ChemicalStructure/PW C000526
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=C(O)C=CC=C1

Reference/KEGG Compound C00079
type: UnificationXref
id: C00079
db: KEGG Compound

ChemicalStructure/PW C108781
type: ChemicalStructure
structure format: SMILES
structure data: OC12CN=CN=C1NCCN2

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChemSpider 972
type: UnificationXref
id: 972
db: ChemSpider

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/KEGG Compound C05650
type: UnificationXref
id: C05650
db: KEGG Compound

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

Phenylpyruvic acid
type: SmallMolecule
entity reference: Phenylpyruvic acid

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Reference/UniProt Q9VY42
type: UnificationXref
id: Q9VY42
db: UniProt

Hydrogen peroxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen peroxide

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChemSpider 5910
type: UnificationXref
id: 5910
db: ChemSpider

Compound/PW C000526/Stoichiometry/1.0
type: Stoichiometry
physical entity: ortho-Hydroxyphenylacetic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 156
type: UnificationXref
id: 156
db: PubChem-compound

Phenylalanine, Tyrosine and Tryptophan Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112740
pathway component: SubPathwayInteraction112740
name: SubPathway

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Tyrosine, Piperidine and Pyridine Alkaloid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112741
pathway component: SubPathwayInteraction112741
name: SubPathway

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 30745
type: UnificationXref
id: CHEBI:30745
db: ChEBI

Protein henna
type: ProteinReference
xref: Reference/UniProt Q27600
organism: BiologicalState579

Reference/BioCyc PHENYLETHYLAMINE
type: UnificationXref
id: PHENYLETHYLAMINE
db: BioCyc

Reference/CAS 122-78-1
type: UnificationXref
id: 122-78-1
db: CAS

Reference/CAS 103-82-2
type: UnificationXref
id: 103-82-2
db: CAS

ChemicalStructure/PW C007816
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC=CC=C1

Reference/ChEBI CHEBI 30851
type: UnificationXref
id: CHEBI:30851
db: ChEBI

Compound/PW C000131/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylpyruvic acid
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Compound/PW C000135/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylacetic acid
stoichiometric coefficient: 1.0

AT01267p
type: Protein
cellular location: Mitochondrion
entity reference: AT01267p

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

1.14.16.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000945/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108781/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000103/Stoichiometry/1.0
right: 4a-Hydroxy-5,6,7,8-tetrahydropteridine
right: L-Tyrosine
spontaneous: false
EC number: 1.14.16.1
left: Oxygen
left: L-Phenylalanine
left: Tetrahydropteridine
name: L-Phenylalanine + Oxygen + Tetrahydropteridine → 4a-Hydroxy-5,6,7,8-tetrahydropteridine + L-Tyrosine
conversion direction: LEFT_TO_RIGHT

2.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000131/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: L-Glutamic acid
right: Phenylpyruvic acid
spontaneous: false
EC number: 2.6.1.1
left: Oxoglutaric acid
left: L-Phenylalanine
name: L-Phenylalanine + Oxoglutaric acid ↔ L-Glutamic acid + Phenylpyruvic acid
conversion direction: REVERSIBLE

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

L-Phenylalanine
type: SmallMolecule
entity reference: L-Phenylalanine
name: SubPathwayOutput

L-Tyrosine
type: SmallMolecule
entity reference: L-Tyrosine

Compound/PW C007816/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylethylamine
stoichiometric coefficient: 1.0

Aromatic-L-amino-acid decarboxylase
type: Protein
entity reference: Aromatic-L-amino-acid decarboxylase