Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

ReactionCatalysis138543
type: Catalysis
controller: Acetyl-CoA acetyltransferase, mitochondrial
controlled: 2.3.1.9
control type: ACTIVATION

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C01089
type: UnificationXref
id: C01089
db: KEGG Compound

Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Acetoacetyl-CoA
type: SmallMolecule
entity reference: Acetoacetyl-CoA

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayInput

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Pyruvate dehydrogenase E1 component subunit beta
type: Protein
cellular location: Mitochondrial membrane
entity reference: Pyruvate dehydrogenase E1 component subunit beta

Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial

Acetyl-CoA acetyltransferase, mitochondrial
type: Complex
component stoichiometry: Protein/15188 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: LD24105p

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Acetoacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15344
xref: Reference/HMDB HMDB0000060
xref: Reference/BioCyc 3-KETOBUTYRATE
xref: Reference/KEGG Compound C00164
xref: Reference/PubChem-compound 96
xref: Reference/CAS 541-50-4
xref: Reference/ChemSpider 94
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000042

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

(R)-3-Hydroxybutyric acid
type: SmallMoleculeReference
xref: Reference/CAS 625-72-9
xref: Reference/BioCyc CPD-335
xref: Reference/PubChem-compound 92135
xref: Reference/KEGG Compound C01089
xref: Reference/ChemSpider 83181
xref: Reference/HMDB HMDB0000011
xref: Reference/ChEBI CHEBI 17066
chemical formula: C4H8O3
molecular weight: 104.04734
structure: ChemicalStructure/PW C000006

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: Protein
entity reference: 3-hydroxy-3-methylglutaryl coenzyme A synthase

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reference/UniProt Q7K4Q9
type: UnificationXref
id: Q7K4Q9
db: UniProt

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrial membrane
entity reference: Pyruvic acid

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

(3S)-hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (3S)-hydroxy-3-methylglutaryl-CoA

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Compound/PW C108786 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3S)-hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Compound/PW C000164 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9W058
organism: Drosophila melanogaster

Protein/14859 Mitochondrial membrane/Stoichiometry/24.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase
stoichiometric coefficient: 24.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

ReactionCoupledTransportCatalysis519
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: ReactionCoupledTransport476
control type: ACTIVATION

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Mitochondrial membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0031966

4.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108786 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: Acetoacetic acid
spontaneous: false
EC number: 4.1.3.4
left: (3S)-hydroxy-3-methylglutaryl-CoA
name: (3S)-hydroxy-3-methylglutaryl-CoA ↔ Acetoacetic acid + Acetyl-CoA
conversion direction: REVERSIBLE

1.1.1.239,1.1.1.62
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000006 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetoacetic acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.239,1.1.1.62
left: NAD
left: (R)-3-Hydroxybutyric acid
name: (R)-3-Hydroxybutyric acid + NAD ↔ Acetoacetic acid + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/BioCyc CPD-335
type: UnificationXref
id: CPD-335
db: BioCyc

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

ChemicalStructure/PW C000006
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)CC(O)=O

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Short-chain dehydrogenase/reductase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Short-chain dehydrogenase/reductase

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/14851 Mitochondrial membrane/Stoichiometry/60.0
component stoichiometry: Protein/14846 Mitochondrial membrane/Stoichiometry/60.0
component stoichiometry: Protein/14856 Mitochondrial membrane/Stoichiometry/60.0
component stoichiometry: Protein/14859 Mitochondrial membrane/Stoichiometry/24.0
cellular location: Mitochondrial membrane
component: Pyruvate dehydrogenase E1 component subunit alpha
component: AT21758p
component: Pyruvate dehydrogenase E1 component subunit beta
component: Dihydrolipoyl dehydrogenase

ReactionCoupledTransport476
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Mitochondrial membrane/Stoichiometry/1.0
right: Pyruvic acid
spontaneous: false
left: Acetyl-CoA
name: Acetyl-CoA ← Pyruvic acid
conversion direction: RIGHT_TO_LEFT

(3S)-hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
entity reference: (3S)-hydroxy-3-methylglutaryl-CoA

Reference/ChemSpider 94
type: UnificationXref
id: 94
db: ChemSpider

Reference/ChemSpider 83181
type: UnificationXref
id: 83181
db: ChemSpider

ReactionCatalysis202326
type: Catalysis
controller: Short-chain dehydrogenase/reductase
controlled: 1.1.1.239,1.1.1.62
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

ReactionCatalysis202325
type: Catalysis
controller: 3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A
controlled: 4.1.3.4
control type: ACTIVATION

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Reference/UniProt Q9VM58
type: UnificationXref
id: Q9VM58
db: UniProt

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/PathWhiz PW123925
type: UnificationXref
id: PW123925
db: PathWhiz

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

(3S)-hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/CAS 1553-55-5
xref: Reference/PubChem-compound 3649
xref: Reference/KEGG Compound C00356
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C108786

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Protein/15188 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: LD24105p
stoichiometric coefficient: 4.0

(R)-3-Hydroxybutyric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (R)-3-Hydroxybutyric acid

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

ReactionCatalysis202300
type: Catalysis
controller: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
controlled: 2.8.3.5
control type: ACTIVATION

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

AT21758p
type: Protein
cellular location: Mitochondrial membrane
entity reference: AT21758p

Reference/UniProt Q9W3N9
type: UnificationXref
id: Q9W3N9
db: UniProt

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 3649
type: UnificationXref
id: 3649
db: PubChem-compound

Reference/SMPDB SMP0122611
type: UnificationXref
id: SMP0122611
db: SMPDB

LD24105p
type: Protein
cellular location: Mitochondrial Matrix
entity reference: LD24105p

2.3.3.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108786/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: Hydrogen Ion
right: (3S)-hydroxy-3-methylglutaryl-CoA
spontaneous: false
EC number: 2.3.3.10
left: Water
left: Acetoacetyl-CoA
left: Acetyl-CoA
name: Acetoacetyl-CoA + Acetyl-CoA + Water → (3S)-hydroxy-3-methylglutaryl-CoA + Coenzyme A + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Reference/BioCyc 3-KETOBUTYRATE
type: UnificationXref
id: 3-KETOBUTYRATE
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17066
type: UnificationXref
id: CHEBI:17066
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

SubPathwayInteraction112732
type: Interaction
name: SubPathway112732Reaction
name: SubPathwayReaction
participant: Acetoacetic acid

SubPathwayInteraction112733
type: Interaction
name: SubPathway112733Reaction
name: SubPathwayReaction
participant: Acetoacetyl-CoA

SubPathwayInteraction112734
type: Interaction
name: SubPathway112734Reaction
name: SubPathwayReaction
participant: Acetoacetyl-CoA

SubPathwayInteraction112735
type: Interaction
name: SubPathwayReaction
name: SubPathway112735Reaction
participant: Acetyl-CoA

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/HMDB HMDB0000011
type: UnificationXref
id: HMDB0000011
db: HMDB

Reference/UniProt Q9VM13
type: UnificationXref
id: Q9VM13
db: UniProt

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

LD24105p
type: ProteinReference
xref: Reference/UniProt Q9W3N9
organism: Drosophila melanogaster

Reference/KEGG Compound C00164
type: UnificationXref
id: C00164
db: KEGG Compound

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Compound/PW C000006 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-3-Hydroxybutyric acid
stoichiometric coefficient: 1.0

Reference/UniProt Q9W058
type: UnificationXref
id: Q9W058
db: UniProt

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinyl-CoA

Compound/PW C001142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/UniProt Q7K5K3
type: UnificationXref
id: Q7K5K3
db: UniProt

Dihydrolipoyl dehydrogenase
type: Protein
cellular location: Mitochondrial membrane
entity reference: Dihydrolipoyl dehydrogenase

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

2.8.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Succinic acid
right: Acetoacetyl-CoA
spontaneous: false
EC number: 2.8.3.5
left: Succinyl-CoA
left: Acetoacetic acid
name: Acetoacetic acid + Succinyl-CoA ↔ Acetoacetyl-CoA + Succinic acid
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetoacetyl-CoA
name: SubPathwayOutput
name: SubPathwayInput

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Synthesis and Degradation of Ketone Bodies
type: Pathway
pathway order: PathwayEnzymeReaction/2460584
pathway order: PathwayEnzymeReaction/2461321
pathway order: PathwaySubPathway/112732
pathway order: PathwaySubPathway/112733
pathway order: PathwaySubPathway/112734
pathway order: PathwaySubPathway/112735
pathway order: PathwayEnzymeReaction/2460490
pathway order: PathwayEnzymeReaction/2461678
pathway order: PathwayEnzymeReaction/2460378
pathway order: PathwayEnzymeReaction/2460585
pathway component: 2.3.3.10
pathway component: 4.1.3.4
pathway component: 1.1.1.239,1.1.1.62
pathway component: ReactionCatalysis202326
pathway component: 2.3.1.9
pathway component: ReactionCatalysis138543
pathway component: ReactionCatalysis202300
pathway component: ReactionCatalysis202325
pathway component: 2.8.3.5
pathway component: ReactionCatalysis202281
pathway component: Fatty acid degradation
pathway component: Butanoate metabolism
pathway component: Glycolysis
pathway component: Pyruvate metabolism
pathway component: ReactionCoupledTransport476
pathway component: ReactionCoupledTransportCatalysis519
xref: Reference/SMPDB SMP0122611
xref: Reference/PathWhiz PW123925
organism: Drosophila melanogaster

Reference/UniProt Q9VAH3
type: UnificationXref
id: Q9VAH3
db: UniProt

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.9
left: Acetyl-CoA
name: 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial membrane
entity reference: Acetyl-CoA

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

ChemicalStructure/PW C000042
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)CC(O)=O

3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A
type: Protein
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
xref: Reference/UniProt Q7K4Q9

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000808 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Acetoacetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetoacetic acid
name: SubPathwayInput

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Compound/PW C108786/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3S)-hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt Q9W4H7
type: UnificationXref
id: Q9W4H7
db: UniProt

Protein/23304 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

ChemicalStructure/PW C108786
type: ChemicalStructure
structure format: SMILES

Reference/CAS 625-72-9
type: UnificationXref
id: 625-72-9
db: CAS

Fatty acid degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112733
pathway component: SubPathwayInteraction112733
name: SubPathway

Butanoate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112732
pathway component: SubPathwayInteraction112732
name: SubPathway

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112735
pathway component: SubPathwayInteraction112735
name: SubPathway

Reference/PubChem-compound 92135
type: UnificationXref
id: 92135
db: PubChem-compound

Pyruvate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112734
pathway component: SubPathwayInteraction112734
name: SubPathway

Protein/14846 Mitochondrial membrane/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit alpha
stoichiometric coefficient: 60.0

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Pyruvate dehydrogenase E1 component subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9W4H7
organism: Drosophila melanogaster

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Pyruvate dehydrogenase E1 component subunit alpha
type: Protein
cellular location: Mitochondrial membrane
entity reference: Pyruvate dehydrogenase E1 component subunit alpha

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Pyruvate dehydrogenase E1 component subunit beta
type: ProteinReference
xref: Reference/UniProt Q7K5K3
organism: Drosophila melanogaster

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Protein/14851 Mitochondrial membrane/Stoichiometry/60.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta
stoichiometric coefficient: 60.0

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ReactionCatalysis202281
type: Catalysis
controller: 3-hydroxy-3-methylglutaryl coenzyme A synthase
controlled: 2.3.3.10
control type: ACTIVATION

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000940 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C000042 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetic acid
stoichiometric coefficient: 1.0

Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
type: Complex
component stoichiometry: Protein/23304 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial

Reference/HMDB HMDB0000060
type: UnificationXref
id: HMDB0000060
db: HMDB

Reference/PubChem-compound 96
type: UnificationXref
id: 96
db: PubChem-compound

Dihydrolipoyl dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q9VVL7
organism: Drosophila melanogaster

AT21758p
type: ProteinReference
xref: Reference/UniProt Q9VM13
organism: Drosophila melanogaster

Reference/ChEBI CHEBI 15344
type: UnificationXref
id: CHEBI:15344
db: ChEBI

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid

Reference/UniProt Q9VVL7
type: UnificationXref
id: Q9VVL7
db: UniProt

3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A
type: ProteinReference
xref: Reference/UniProt Q9VM58
organism: Drosophila melanogaster

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Short-chain dehydrogenase/reductase
type: ProteinReference
xref: Reference/UniProt Q9VAH3
organism: Drosophila melanogaster

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/GENE ONTOLOGY GO 0031966
type: UnificationXref
id: GO:0031966
db: GENE ONTOLOGY

Reference/CAS 541-50-4
type: UnificationXref
id: 541-50-4
db: CAS

Protein/14856 Mitochondrial membrane/Stoichiometry/60.0
type: Stoichiometry
physical entity: AT21758p
stoichiometric coefficient: 60.0

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS