Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 388350
type: UnificationXref
id: 388350
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/CAS 18186-48-6
type: UnificationXref
id: 18186-48-6
db: CAS

Reference/KEGG Compound C00794
type: UnificationXref
id: C00794
db: KEGG Compound

Compound/PW C000517 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Fructose
stoichiometric coefficient: 1.0

Fructose-1,6-bisphosphatase 1
type: Complex
component stoichiometry: Protein/15635 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Fructose-1,6-bisphosphatase, isoform F

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

GDP-4-Dehydro-6-deoxy-D-mannose
type: SmallMolecule
cellular location: Cytosol
entity reference: GDP-4-Dehydro-6-deoxy-D-mannose

Reference/UniProt P50053
type: UnificationXref
id: P50053
db: UniProt

Reference/KEGG Compound C00325
type: UnificationXref
id: C00325
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/CAS 53188-23-1
type: UnificationXref
id: 53188-23-1
db: CAS

Reference/HMDB HMDB0001078
type: UnificationXref
id: HMDB0001078
db: HMDB

Reference/ChemSpider 388338
type: UnificationXref
id: 388338
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00577
type: UnificationXref
id: C00577
db: KEGG Compound

Compound/PW C108886 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diphosphoric acid
stoichiometric coefficient: 1.0

Reference/UniProt P34949
type: UnificationXref
id: P34949
db: UniProt

Reference/BioCyc MANNOSE-1P
type: UnificationXref
id: MANNOSE-1P
db: BioCyc

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Compound/PW C000111 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Mannose
stoichiometric coefficient: 1.0

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Reference/CAS 27251-84-9
type: UnificationXref
id: 27251-84-9
db: CAS

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

D-Fructose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Fructose 1-phosphate

Reference/UniProt Q9TY56
type: UnificationXref
id: Q9TY56
db: UniProt

Drosophila melanogaster
type: BioSource
xref: Reference/TAXONOMY 7227

Reference/HMDB HMDB0001095
type: UnificationXref
id: HMDB0001095
db: HMDB

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Reference/ChemSpider 388554
type: UnificationXref
id: 388554
db: ChemSpider

Reference/UniProt Q13630
type: UnificationXref
id: Q13630
db: UniProt

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis202436
type: Catalysis
controller: Hexokinase type 2
controlled: Reaction212796
control type: ACTIVATION

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ReactionCatalysis202437
type: Catalysis
controller: Phosphomannomutase 1
controlled: Reaction212797
control type: ACTIVATION

ReactionCatalysis202438
type: Catalysis
controller: Mannose-1-phosphate guanyltransferase beta
controlled: Reaction212798
control type: ACTIVATION

Reference/ChemSpider 389526
type: UnificationXref
id: 389526
db: ChemSpider

ReactionCatalysis202439
type: Catalysis
controller: GDP-mannose 4,6 dehydratase
controlled: Reaction212799
control type: ACTIVATION

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

ReactionCatalysis202432
type: Catalysis
controller: 6-phosphofructokinase, liver type
controlled: Reaction212793
control type: ACTIVATION

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Phosphomannomutase 1
type: Protein
cellular location: Cytosol
entity reference: Phosphomannomutase 1

ReactionCatalysis202435
type: Catalysis
controller: Mannose-6-phosphate isomerase
controlled: Reaction212795
control type: ACTIVATION

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000168 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sorbitol
stoichiometric coefficient: 1.0

ReactionCatalysis202430
type: Catalysis
controller: Fructose-bisphosphate aldolase
controlled: Reaction212791
control type: ACTIVATION

Reference/CAS 50-70-4
type: UnificationXref
id: 50-70-4
db: CAS

ReactionCatalysis202431
type: Catalysis
controller: Ketohexokinase
controlled: Reaction212792
control type: ACTIVATION

Reference/PubChem-compound 439198
type: UnificationXref
id: 439198
db: PubChem-compound

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

ATP-dependent 6-phosphofructokinase
type: Protein
cellular location: Cytosol
entity reference: ATP-dependent 6-phosphofructokinase

TransportCatalysis2055
type: Catalysis
controller: Unknown
controlled: Transport10889
control type: ACTIVATION

TransportCatalysis2054
type: Catalysis
controller: Unknown
controlled: Transport10888
control type: ACTIVATION

D-Fructose
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-535
xref: Reference/ChEBI CHEBI 28645
xref: Reference/ChemSpider 388775
xref: Reference/PubChem-compound 439709
xref: Reference/KEGG Compound C02336
xref: Reference/HMDB HMDB0000660
xref: Reference/CAS 53188-23-1
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000517

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

GDP-L-fucose
type: SmallMolecule
cellular location: Cytosol
entity reference: GDP-L-fucose

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

ReactionCatalysis202440
type: Catalysis
controller: GDP-L-fucose synthase
controlled: Reaction212800
control type: ACTIVATION

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/BioCyc MANNOSE-6P
type: UnificationXref
id: MANNOSE-6P
db: BioCyc

α-D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003345
xref: Reference/ChemSpider 71358
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/PubChem-compound 79025
xref: Reference/ChEBI CHEBI 17925
xref: Reference/CAS 492-62-6
xref: Reference/KEGG Compound C00267
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C001851

Reference/ChemSpider 388775
type: UnificationXref
id: 388775
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/ChEBI CHEBI 17009
type: UnificationXref
id: CHEBI:17009
db: ChEBI

Reference/KEGG Compound C01222
type: UnificationXref
id: C01222
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/UniProt Q92871
type: UnificationXref
id: Q92871
db: UniProt

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

ChemicalStructure/PW C000901
type: ChemicalStructure
structure format: SMILES

Mannose 6-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc MANNOSE-6P
xref: Reference/PubChem-compound 439198
xref: Reference/ChemSpider 388338
xref: Reference/ChEBI CHEBI 49728
xref: Reference/CAS 3672-15-9
xref: Reference/KEGG Compound C00275
xref: Reference/HMDB HMDB0001078
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000848

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Hexokinase type 2
type: Protein
cellular location: Cytosol
entity reference: Hexokinase type 2

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/HMDB HMDB0006330
type: UnificationXref
id: HMDB0006330
db: HMDB

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

ReactionCatalysis202429
type: Catalysis
controller: Triosephosphate isomerase
controlled: Reaction212790
control type: ACTIVATION

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 17378
type: UnificationXref
id: CHEBI:17378
db: ChEBI

ReactionCatalysis202425
type: Catalysis
controller: LD47736p
controlled: Reaction212786
control type: ACTIVATION

ReactionCatalysis202426
type: Catalysis
controller: Hexokinase type 2
controlled: Reaction212787
control type: ACTIVATION

ReactionCatalysis202427
type: Catalysis
controller: Fructose-1,6-bisphosphatase 1
controlled: Reaction212788
control type: ACTIVATION

ReactionCatalysis202428
type: Catalysis
controller: Fructose-bisphosphate aldolase
controlled: Reaction212789
control type: ACTIVATION

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

ReactionCatalysis202424
type: Catalysis
controller: CG6084, isoform D
controlled: Reaction212785
control type: ACTIVATION

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00267
type: UnificationXref
id: C00267
db: KEGG Compound

Reference/PubChem-compound 644175
type: UnificationXref
id: 644175
db: PubChem-compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Reference/PathWhiz PW123943
type: UnificationXref
id: PW123943
db: PathWhiz

GDP-mannose 4,6 dehydratase
type: ProteinReference
xref: Reference/UniProt O60547
organism: Drosophila melanogaster

Compound/PW C001038 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GDP-4-Dehydro-6-deoxy-D-mannose
stoichiometric coefficient: 1.0

GDP-L-fucose
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00325
xref: Reference/PubChem-compound 439211
xref: Reference/ChEBI CHEBI 17009
xref: Reference/ChemSpider 388350
xref: Reference/BioCyc GUANOSINE DIPHOSPHATE FUCOSE
xref: Reference/HMDB HMDB0001095
xref: Reference/CAS 15839-70-0
chemical formula: C16H25N5O15P2
molecular weight: 589.0822
structure: ChemicalStructure/PW C000861

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/ChEBI CHEBI 28013
type: UnificationXref
id: CHEBI:28013
db: ChEBI

Reference/UniProt Q9Y100
type: UnificationXref
id: Q9Y100
db: UniProt

Reference/CAS 3672-15-9
type: UnificationXref
id: 3672-15-9
db: CAS

Reference/KEGG Compound C00275
type: UnificationXref
id: C00275
db: KEGG Compound

D-Mannose 1-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00636
xref: Reference/ChemSpider 559210
xref: Reference/CAS 27251-84-9
xref: Reference/HMDB HMDB0006330
xref: Reference/ChEBI CHEBI 35374
xref: Reference/BioCyc MANNOSE-1P
xref: Reference/PubChem-compound 644175
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C002722

Reference/KEGG Compound C02336
type: UnificationXref
id: C02336
db: KEGG Compound

Reference/KEGG Compound C00159
type: UnificationXref
id: C00159
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Amino sugar and nucleotide sugar metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112773
pathway component: SubPathwayInteraction112773
name: SubPathway

Galactose metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112772
pathway component: SubPathwayInteraction112772
name: SubPathway

Reference/HMDB HMDB0001346
type: UnificationXref
id: HMDB0001346
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reaction212785
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001851 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000168 Cytosol/Stoichiometry/1.0
right: α-D-Glucose
right: Hydrogen Ion
right: NADPH
spontaneous: false
left: Sorbitol
left: NADP
name: NADP + Sorbitol ↔ Hydrogen Ion + NADPH + α-D-Glucose
conversion direction: REVERSIBLE

Reference/UniProt O96299
type: UnificationXref
id: O96299
db: UniProt

Reaction212786
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000168 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Cytosol/Stoichiometry/1.0
right: D-Fructose
right: Hydrogen Ion
right: NADH
spontaneous: false
left: NAD
left: Sorbitol
name: NAD + Sorbitol ↔ D-Fructose + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reaction212787
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002021 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: β-D-Fructose 6-phosphate
spontaneous: false
left: D-Fructose
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Fructose ↔ Adenosine diphosphate + β-D-Fructose 6-phosphate
conversion direction: REVERSIBLE

Reaction212788
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108883 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002021 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: β-D-Fructose 1,6-bisphosphate
right: Water
spontaneous: false
left: Phosphoric acid
left: β-D-Fructose 6-phosphate
name: Phosphoric acid + β-D-Fructose 6-phosphate ↔ Water + β-D-Fructose 1,6-bisphosphate
conversion direction: REVERSIBLE

Reaction212789
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108883 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
left: β-D-Fructose 1,6-bisphosphate
name: β-D-Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Reference/PathWhiz PW088410
type: UnificationXref
id: PW088410
db: PathWhiz

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

N-Glycan biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112786
pathway component: SubPathwayInteraction112786
name: SubPathway

ChemicalStructure/PW C001038
type: ChemicalStructure
structure format: SMILES

Fructose and Mannose Metabolism
type: Pathway
pathway order: PathwaySubPathway/112786
pathway order: PathwaySubPathway/112787
pathway order: PathwayTransport/2461674
pathway order: PathwayTransport/2461675
pathway order: PathwayEnzymeReaction/2460712
pathway order: PathwayEnzymeReaction/2460723
pathway order: PathwayEnzymeReaction/2460721
pathway order: PathwayEnzymeReaction/2460732
pathway order: PathwayEnzymeReaction/2460722
pathway order: PathwayEnzymeReaction/2460733
pathway order: PathwayEnzymeReaction/2460730
pathway order: PathwayEnzymeReaction/2460720
pathway order: PathwayEnzymeReaction/2460731
pathway order: PathwayEnzymeReaction/2460718
pathway order: PathwayEnzymeReaction/2460729
pathway order: PathwayEnzymeReaction/2460719
pathway order: PathwayEnzymeReaction/2460717
pathway order: PathwayEnzymeReaction/2460728
pathway order: PathwayEnzymeReaction/2460715
pathway order: PathwaySubPathway/112772
pathway order: PathwaySubPathway/112773
pathway component: Reaction212796
pathway component: Reaction212797
pathway component: Reaction212798
pathway component: Reaction212799
pathway component: ReactionCatalysis202436
pathway component: ReactionCatalysis202437
pathway component: ReactionCatalysis202438
pathway component: ReactionCatalysis202439
pathway component: ReactionCatalysis202432
pathway component: Glycolysis
pathway component: Reaction212790
pathway component: Transport10888
pathway component: Reaction212791
pathway component: ReactionCatalysis202435
pathway component: Transport10889
pathway component: Reaction212792
pathway component: Reaction212793
pathway component: ReactionCatalysis202430
pathway component: ReactionCatalysis202431
pathway component: Reaction212795
pathway component: Amino sugar and nucleotide sugar metabolism
pathway component: Galactose metabolism
pathway component: TransportCatalysis2055
pathway component: TransportCatalysis2054
pathway component: Reaction212785
pathway component: ReactionCatalysis202429
pathway component: Reaction212786
pathway component: Reaction212787
pathway component: Reaction212788
pathway component: ReactionCatalysis202425
pathway component: Reaction212789
pathway component: Reaction212800
pathway component: ReactionCatalysis202426
pathway component: ReactionCatalysis202427
pathway component: ReactionCatalysis202428
pathway component: ReactionCatalysis202424
pathway component: ReactionCatalysis202440
pathway component: N-Glycan biosynthesis
xref: Reference/PathWhiz PW123943
xref: Reference/SMPDB SMP0122628
organism: Drosophila melanogaster

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reaction212796
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000848 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000111 Cytosol/Stoichiometry/1.0
right: Mannose 6-phosphate
right: Adenosine diphosphate
spontaneous: false
left: D-Mannose
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Mannose ↔ Adenosine diphosphate + Mannose 6-phosphate
conversion direction: REVERSIBLE

Reaction212797
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000848 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002722 Cytosol/Stoichiometry/1.0
right: D-Mannose 1-phosphate
spontaneous: false
left: Mannose 6-phosphate
name: Mannose 6-phosphate ↔ D-Mannose 1-phosphate
conversion direction: REVERSIBLE

Compound/PW C000861 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GDP-L-fucose
stoichiometric coefficient: 1.0

Reaction212798
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000901 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108886 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002722 Cytosol/Stoichiometry/1.0
right: Diphosphoric acid
right: Guanosine diphosphate mannose
spontaneous: false
left: D-Mannose 1-phosphate
left: Guanosine triphosphate
name: D-Mannose 1-phosphate + Guanosine triphosphate ↔ Diphosphoric acid + Guanosine diphosphate mannose
conversion direction: REVERSIBLE

Reaction212799
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000901 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001038 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: GDP-4-Dehydro-6-deoxy-D-mannose
right: Water
spontaneous: false
left: Guanosine diphosphate mannose
name: Guanosine diphosphate mannose ↔ GDP-4-Dehydro-6-deoxy-D-mannose + Water
conversion direction: REVERSIBLE

Unknown
type: ProteinReference

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Reaction212790
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
spontaneous: false
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

Reaction212791
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108884 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108885 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
right: D-Glyceraldehyde
spontaneous: false
left: D-Fructose 1-phosphate
name: D-Fructose 1-phosphate ↔ D-Glyceraldehyde + Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reaction212792
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108884 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: D-Fructose 1-phosphate
spontaneous: false
left: D-Fructose
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Fructose ↔ Adenosine diphosphate + D-Fructose 1-phosphate
conversion direction: REVERSIBLE

Reaction212793
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108883 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002021 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: β-D-Fructose 1,6-bisphosphate
spontaneous: false
left: Adenosine triphosphate
left: β-D-Fructose 6-phosphate
name: Adenosine triphosphate + β-D-Fructose 6-phosphate ↔ Adenosine diphosphate + β-D-Fructose 1,6-bisphosphate
conversion direction: REVERSIBLE

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reaction212795
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000848 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002021 Cytosol/Stoichiometry/1.0
right: β-D-Fructose 6-phosphate
spontaneous: false
left: Mannose 6-phosphate
name: Mannose 6-phosphate ↔ β-D-Fructose 6-phosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C108885
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)C=O

ChemicalStructure/PW C108884
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C108883
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C108886
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 492-62-6
type: UnificationXref
id: 492-62-6
db: CAS

Compound/PW C001851 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: α-D-Glucose
stoichiometric coefficient: 1.0

Compound/PW C002722 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Mannose 1-phosphate
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C002021 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Fructose 6-phosphate
stoichiometric coefficient: 1.0

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Reference/ChEBI CHEBI 16084
type: UnificationXref
id: CHEBI:16084
db: ChEBI

Reference/HMDB HMDB0000169
type: UnificationXref
id: HMDB0000169
db: HMDB

α-D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: α-D-Glucose
name: SubPathwayInput

ChemicalStructure/PW C000168
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

GDP-L-fucose synthase
type: ProteinReference
xref: Reference/UniProt Q13630
organism: Drosophila melanogaster

Transport10888
type: Transport
participant stoichiometry: Compound/PW C000168 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000168 Cytosol/Stoichiometry/1.0
right: Sorbitol
spontaneous: false
left: Sorbitol
name: Sorbitol (←) Transport: Drosophila melanogaster, Cell, Mitochondrial Matrix to Drosophila melanogaster, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Transport10889
type: Transport
participant stoichiometry: Compound/PW C000517 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Cytosol/Stoichiometry/1.0
right: D-Fructose
spontaneous: false
left: D-Fructose
name: D-Fructose (→) Transport: Drosophila melanogaster, Cell, Mitochondrial Matrix to Drosophila melanogaster, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Mannose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt P34949
organism: Drosophila melanogaster

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/ChemSpider 559210
type: UnificationXref
id: 559210
db: ChemSpider

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

D-Mannose
type: SmallMoleculeReference
xref: Reference/CAS 530-26-7
xref: Reference/ChemSpider 17893
xref: Reference/HMDB HMDB0000169
xref: Reference/PubChem-compound 18950
xref: Reference/BioCyc MANNOSE
xref: Reference/KEGG Compound C00159
xref: Reference/ChEBI CHEBI 4208
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000111

Reference/BioCyc GUANOSINE DIPHOSPHATE FUCOSE
type: UnificationXref
id: GUANOSINE_DIPHOSPHATE_FUCOSE
db: BioCyc

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

D-Mannose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Mannose

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/ChemSpider 71358
type: UnificationXref
id: 71358
db: ChemSpider

Compound/PW C108884 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Fructose 1-phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00096
type: UnificationXref
id: C00096
db: KEGG Compound

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 17893
type: UnificationXref
id: 17893
db: ChemSpider

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003345
type: UnificationXref
id: HMDB0003345
db: HMDB

Reference/PubChem-compound 18396
type: UnificationXref
id: 18396
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/HMDB HMDB0001163
type: UnificationXref
id: HMDB0001163
db: HMDB

β-D-Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Fructose 6-phosphate

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Compound/PW C000901 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate mannose
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Mannose-1-phosphate guanyltransferase beta
type: Protein
cellular location: Cytosol
entity reference: Mannose-1-phosphate guanyltransferase beta

ChemicalStructure/PW C002021
type: ChemicalStructure
structure format: SMILES

Protein/1492 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Phosphomannomutase 1
stoichiometric coefficient: 2.0

Diphosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Diphosphoric acid

Mannose-6-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Mannose-6-phosphate isomerase

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Guanosine diphosphate mannose
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate mannose

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/BioCyc CPD-535
type: UnificationXref
id: CPD-535
db: BioCyc

Compound/PW C108883 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Fructose 1,6-bisphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 37515
type: UnificationXref
id: CHEBI:37515
db: ChEBI

Reference/BioCyc MANNOSE
type: UnificationXref
id: MANNOSE
db: BioCyc

Mannose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Mannose 6-phosphate

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/KEGG Compound C01094
type: UnificationXref
id: C01094
db: KEGG Compound

Reference/PubChem-compound 439709
type: UnificationXref
id: 439709
db: PubChem-compound

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Sorbitol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5780
xref: Reference/HMDB HMDB0000247
xref: Reference/ChEBI CHEBI 17924
xref: Reference/ChemSpider 5576
xref: Reference/CAS 50-70-4
xref: Reference/KEGG Compound C00794
chemical formula: C6H14O6
molecular weight: 182.07904
structure: ChemicalStructure/PW C000168

Reference/UniProt Q9NFT8
type: UnificationXref
id: Q9NFT8
db: UniProt

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/HMDB HMDB0000660
type: UnificationXref
id: HMDB0000660
db: HMDB

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Hexokinase type 2
type: ProteinReference
xref: Reference/UniProt Q9NFT8
organism: Drosophila melanogaster

Reference/ChEBI CHEBI 15820
type: UnificationXref
id: CHEBI:15820
db: ChEBI

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C05345
type: UnificationXref
id: C05345
db: KEGG Compound

ChemicalStructure/PW C002722
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/PW C000848 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mannose 6-phosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/PubChem-compound 1023
type: UnificationXref
id: 1023
db: PubChem-compound

Reference/CAS 15978-08-2
type: UnificationXref
id: 15978-08-2
db: CAS

Reference/UniProt Q9Y5P6
type: UnificationXref
id: Q9Y5P6
db: UniProt

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

GDP-4-Dehydro-6-deoxy-D-mannose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001346
xref: Reference/PubChem-compound 439446
xref: Reference/ChemSpider 388554
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/ChEBI CHEBI 16955
xref: Reference/KEGG Compound C01222
xref: Reference/CAS 18186-48-6
chemical formula: C16H23N5O15P2
molecular weight: 587.0666
structure: ChemicalStructure/PW C001038

D-Mannose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Mannose 1-phosphate

Reference/ChEBI CHEBI 35374
type: UnificationXref
id: CHEBI:35374
db: ChEBI

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

SubPathwayInteraction112772
type: Interaction
name: SubPathwayReaction
name: SubPathway112772Reaction
participant: α-D-Glucose

SubPathwayInteraction112773
type: Interaction
name: SubPathway112773Reaction
name: SubPathwayReaction
participant: D-Fructose

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

β-D-Fructose 1,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05378
xref: Reference/ChEBI CHEBI 28013
xref: Reference/PubChem-compound 7752
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C108883

D-Fructose 1-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 15978-08-2
xref: Reference/PubChem-compound 4329
xref: Reference/KEGG Compound C01094
xref: Reference/ChEBI CHEBI 37515
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C108884

D-Glyceraldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17378
xref: Reference/PubChem-compound 79014
xref: Reference/KEGG Compound C00577
xref: Reference/CAS 453-17-8
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C108885

Diphosphoric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 29888
xref: Reference/CAS 2466-09-3
xref: Reference/KEGG Compound C00013
xref: Reference/PubChem-compound 1023
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C108886

GDP-L-fucose synthase
type: Complex
component stoichiometry: Protein/868 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: GDP-L-fucose synthase

Reference/BioCyc GDP-MANNOSE
type: UnificationXref
id: GDP-MANNOSE
db: BioCyc

Triosephosphate isomerase
type: ProteinReference
xref: Reference/UniProt Q9TY56
organism: Drosophila melanogaster

Protein/15667 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Triosephosphate isomerase
stoichiometric coefficient: 2.0

D-Glyceraldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05378
type: UnificationXref
id: C05378
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

β-D-Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440641
xref: Reference/ChemSpider 389526
xref: Reference/ChEBI CHEBI 16084
xref: Reference/KEGG Compound C05345
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/HMDB HMDB0003971
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C002021

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Reference/HMDB HMDB0003971
type: UnificationXref
id: HMDB0003971
db: HMDB

CG6084, isoform D
type: Protein
cellular location: Cytosol
entity reference: CG6084, isoform D

Reference/ChEBI CHEBI 4208
type: UnificationXref
id: CHEBI:4208
db: ChEBI

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17924
type: UnificationXref
id: CHEBI:17924
db: ChEBI

Reference/ChEBI CHEBI 16955
type: UnificationXref
id: CHEBI:16955
db: ChEBI

Ketohexokinase
type: ProteinReference
xref: Reference/UniProt P50053
organism: Drosophila melanogaster

Phosphomannomutase 1
type: ProteinReference
xref: Reference/UniProt Q92871
organism: Drosophila melanogaster

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/PubChem-compound 440641
type: UnificationXref
id: 440641
db: PubChem-compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/ChemSpider 17372
type: UnificationXref
id: 17372
db: ChemSpider

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

ChemicalStructure/PW C000111
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O

Reference/SMPDB SMP0122628
type: UnificationXref
id: SMP0122628
db: SMPDB

6-phosphofructokinase, liver type
type: Complex
component stoichiometry: Protein/15629 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: ATP-dependent 6-phosphofructokinase

Reference/CAS 530-26-7
type: UnificationXref
id: 530-26-7
db: CAS

Reaction212800
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000861 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001038 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: GDP-L-fucose
right: NADP
spontaneous: false
left: Hydrogen Ion
left: GDP-4-Dehydro-6-deoxy-D-mannose
left: NADPH
name: GDP-4-Dehydro-6-deoxy-D-mannose + Hydrogen Ion + NADPH ↔ GDP-L-fucose + NADP
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/ChEBI CHEBI 49728
type: UnificationXref
id: CHEBI:49728
db: ChEBI

Ketohexokinase
type: Complex
component stoichiometry: Protein/1132 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Ketohexokinase

Fructose-1,6-bisphosphatase, isoform F
type: Protein
cellular location: Cytosol
entity reference: Fructose-1,6-bisphosphatase, isoform F

Sorbitol
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Sorbitol

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/HMDB HMDB0000247
type: UnificationXref
id: HMDB0000247
db: HMDB

SubPathwayInteraction112786
type: Interaction
name: SubPathway112786Reaction
name: SubPathwayReaction
participant: Guanosine diphosphate mannose

SubPathwayInteraction112787
type: Interaction
name: SubPathwayReaction
name: SubPathway112787Reaction
participant: D-Glyceraldehyde 3-phosphate

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate
name: SubPathwayOutput

Reference/ChEBI CHEBI 17925
type: UnificationXref
id: CHEBI:17925
db: ChEBI

Reference/CAS 15839-70-0
type: UnificationXref
id: 15839-70-0
db: CAS

Reference/CAS 453-17-8
type: UnificationXref
id: 453-17-8
db: CAS

Reference/TAXONOMY 7227
type: UnificationXref
id: 7227
db: TAXONOMY

Fructose-bisphosphate aldolase
type: Protein
cellular location: Cytosol
entity reference: Fructose-bisphosphate aldolase

Mannose-1-phosphate guanyltransferase beta
type: ProteinReference
xref: Reference/UniProt Q9Y5P6
organism: Drosophila melanogaster

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000848
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Compound/PW C000517 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Fructose
stoichiometric coefficient: 1.0

Reference/PubChem-compound 7752
type: UnificationXref
id: 7752
db: PubChem-compound

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Reference/ChEBI CHEBI 28645
type: UnificationXref
id: CHEBI:28645
db: ChEBI

Ketohexokinase
type: Protein
cellular location: Cytosol
entity reference: Ketohexokinase

Triosephosphate isomerase
type: Complex
component stoichiometry: Protein/15667 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Triosephosphate isomerase

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

β-D-Fructose 1,6-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Fructose 1,6-bisphosphate

Compound/PW C108885 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde
stoichiometric coefficient: 1.0

LD47736p
type: Protein
cellular location: Cytosol
entity reference: LD47736p

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ChemicalStructure/PW C000861
type: ChemicalStructure
structure format: SMILES

ATP-dependent 6-phosphofructokinase
type: ProteinReference
xref: Reference/UniProt Q9Y100
organism: Drosophila melanogaster

Fructose-1,6-bisphosphatase, isoform F
type: ProteinReference
xref: Reference/UniProt C6SV43
organism: Drosophila melanogaster

D-Fructose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Fructose
name: SubPathwayOutput

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439211
type: UnificationXref
id: 439211
db: PubChem-compound

Reference/PubChem-compound 79014
type: UnificationXref
id: 79014
db: PubChem-compound

Phosphomannomutase 1
type: Complex
component stoichiometry: Protein/1492 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Phosphomannomutase 1

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Protein/868 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: GDP-L-fucose synthase
stoichiometric coefficient: 2.0

Fructose-bisphosphate aldolase
type: ProteinReference
xref: Reference/UniProt Q9VBG3
organism: Drosophila melanogaster

Reference/ChemSpider 5576
type: UnificationXref
id: 5576
db: ChemSpider

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/PubChem-compound 439446
type: UnificationXref
id: 439446
db: PubChem-compound

Protein/1132 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ketohexokinase
stoichiometric coefficient: 2.0

LD47736p
type: ProteinReference
xref: Reference/UniProt O96299
organism: Drosophila melanogaster

Reference/UniProt O60547
type: UnificationXref
id: O60547
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt C6SV43
type: UnificationXref
id: C6SV43
db: UniProt

Reference/UniProt Q9VBG3
type: UnificationXref
id: Q9VBG3
db: UniProt

Reference/KEGG Compound C00636
type: UnificationXref
id: C00636
db: KEGG Compound

Guanosine diphosphate mannose
type: SmallMoleculeReference
xref: Reference/BioCyc GDP-MANNOSE
xref: Reference/CAS 3123-67-9
xref: Reference/KEGG Compound C00096
xref: Reference/PubChem-compound 18396
xref: Reference/ChemSpider 17372
xref: Reference/ChEBI CHEBI 15820
xref: Reference/HMDB HMDB0001163
chemical formula: C16H25N5O16P2
molecular weight: 605.07715
structure: ChemicalStructure/PW C000901

Reference/SMPDB SMP0087391
type: UnificationXref
id: SMP0087391
db: SMPDB

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/PubChem-compound 4329
type: UnificationXref
id: 4329
db: PubChem-compound

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/PubChem-compound 18950
type: UnificationXref
id: 18950
db: PubChem-compound

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Triosephosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Triosephosphate isomerase

Reference/ChEBI CHEBI 29888
type: UnificationXref
id: CHEBI:29888
db: ChEBI

Reference/CAS 3123-67-9
type: UnificationXref
id: 3123-67-9
db: CAS

Reference/PubChem-compound 79025
type: UnificationXref
id: 79025
db: PubChem-compound

Protein/15629 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: ATP-dependent 6-phosphofructokinase
stoichiometric coefficient: 4.0

Reference/UniProt M9PI17
type: UnificationXref
id: M9PI17
db: UniProt

GDP-L-fucose synthase
type: Protein
cellular location: Cytosol
entity reference: GDP-L-fucose synthase

Reference/CAS 2466-09-3
type: UnificationXref
id: 2466-09-3
db: CAS

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112787
pathway component: SubPathwayInteraction112787
xref: Reference/PathWhiz PW088410
xref: Reference/SMPDB SMP0087391
name: SubPathway

Sorbitol
type: SmallMolecule
cellular location: Cytosol
entity reference: Sorbitol

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Protein/15635 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fructose-1,6-bisphosphatase, isoform F
stoichiometric coefficient: 4.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

D-Fructose
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: D-Fructose

Reference/PubChem-compound 5780
type: UnificationXref
id: 5780
db: PubChem-compound

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

Guanosine diphosphate mannose
type: SmallMolecule
entity reference: Guanosine diphosphate mannose
name: SubPathwayOutput

ChemicalStructure/PW C000517
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O

Compound/PW C000168 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sorbitol
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001851
type: ChemicalStructure
structure format: SMILES

CG6084, isoform D
type: ProteinReference
xref: Reference/UniProt M9PI17
organism: Drosophila melanogaster

GDP-mannose 4,6 dehydratase
type: Protein
cellular location: Cytosol
entity reference: GDP-mannose 4,6 dehydratase