Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Bifunctional TH2 protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt F4KFT7
organism: Arabidopsis thaliana

Bifunctional TENA-E protein
type: ProteinReference
xref: Reference/UniProt Q9ASY9
organism: Arabidopsis thaliana

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Hydroxyethylthiazole kinase
type: ProteinReference
xref: Reference/UniProt Q9LIQ4
organism: Arabidopsis thaliana

Thiamine pyrophosphokinase 1
type: ProteinReference
xref: Reference/UniProt B9DGU7
organism: Arabidopsis thaliana

Phosphomethylpyrimidine synthase, chloroplastic
type: ProteinReference
xref: Reference/UniProt O82392
organism: Arabidopsis thaliana

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q5M731
organism: Arabidopsis thaliana

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

4-Amino-5-aminomethyl-2-methylpyrimidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 4-Amino-5-aminomethyl-2-methylpyrimidine

5-Aminoimidazole ribonucleotide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03373
xref: Reference/HMDB HMDB0001235
xref: Reference/ChEBI CHEBI 28843
xref: Reference/ChemSpider 141854
xref: Reference/CAS 25635-88-5
xref: Reference/PubChem-compound 161500
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
chemical formula: C8H14N3O7P
molecular weight: 295.05695
structure: ChemicalStructure/PW C000955

Reference/PubChem-compound 3382778
type: UnificationXref
id: 3382778
db: PubChem-compound

ChemicalStructure/PW C014066
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCO)SC=N1

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Compound/PW C000721 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02743
type: UnificationXref
id: C02743
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Compound/PW C001165 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 135626338
type: UnificationXref
id: 135626338
db: PubChem-compound

Adenylate kinase 3
type: ProteinReference
xref: Reference/UniProt Q9FK35
organism: Arabidopsis thaliana

At5g66005
type: ProteinReference
xref: Reference/UniProt Q6ID68
organism: Arabidopsis thaliana

Thiamine thiazole synthase, chloroplastic
type: ProteinReference
xref: Reference/UniProt Q38814
organism: Arabidopsis thaliana

2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate

2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate

Reference/PubChem-compound 439182
type: UnificationXref
id: 439182
db: PubChem-compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C000414 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

4-Methyl-5-(2-phosphooxyethyl)thiazole
type: SmallMolecule
cellular location: Chloroplast
entity reference: 4-Methyl-5-(2-phosphooxyethyl)thiazole

Compound/PW C109074 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001086
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)C1=CC=CN=C1

Reference/GENE ONTOLOGY GO 0009507
type: UnificationXref
id: GO:0009507
db: GENE ONTOLOGY

Compound/PW C000921 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/CAS 154-87-0
type: UnificationXref
id: 154-87-0
db: CAS

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Niacinamide
type: SmallMolecule
cellular location: Chloroplast
entity reference: Niacinamide

Reference/UniProt O82392
type: UnificationXref
id: O82392
db: UniProt

Compound/PW C109075 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 936
type: UnificationXref
id: 936
db: PubChem-compound

4-Amino-5-hydroxymethyl-2-methylpyrimidine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 777
xref: Reference/ChEBI CHEBI 16892
chemical formula: C6H9N3O
molecular weight: 139.07455
structure: ChemicalStructure/PW C043231

Glycine
type: SmallMolecule
cellular location: Chloroplast
entity reference: Glycine

Reference/KEGG Compound C00237
type: UnificationXref
id: C00237
db: KEGG Compound

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Compound/PW C014066/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-(2-Hydroxyethyl)-4-methylthiazole
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

4-Methyl-5-(2-phosphooxyethyl)thiazole
type: SmallMolecule
entity reference: 4-Methyl-5-(2-phosphooxyethyl)thiazole

Reference/ChemSpider 141854
type: UnificationXref
id: 141854
db: ChemSpider

Reference/UniProt Q38814
type: UnificationXref
id: Q38814
db: UniProt

NAD
type: SmallMolecule
cellular location: Chloroplast
entity reference: NAD

Reference/ChemSpider 388325
type: UnificationXref
id: 388325
db: ChemSpider

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

4-Amino-5-hydroxymethyl-2-methylpyrimidine
type: SmallMolecule
cellular location: Chloroplast
entity reference: 4-Amino-5-hydroxymethyl-2-methylpyrimidine

Reference/UniProt Q5M731
type: UnificationXref
id: Q5M731
db: UniProt

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChEBI CHEBI 17154
type: UnificationXref
id: CHEBI:17154
db: ChEBI

Reference/PathWhiz PW123955
type: UnificationXref
id: PW123955
db: PathWhiz

Compound/PW C000955 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Aminoimidazole ribonucleotide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Compound/PW C109084 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/UniProt F4KFT7
type: UnificationXref
id: F4KFT7
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Bifunctional TH2 protein, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Bifunctional TH2 protein, mitochondrial

Reference/HMDB HMDB0032985
type: UnificationXref
id: HMDB0032985
db: HMDB

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChEBI CHEBI 17245
type: UnificationXref
id: CHEBI:17245
db: ChEBI

Reference/KEGG Compound C00378
type: UnificationXref
id: C00378
db: KEGG Compound

Reference/ChemSpider 911
type: UnificationXref
id: 911
db: ChemSpider

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 163311990
xref: Reference/KEGG Compound C20247
chemical formula: C7H10NO6PS
molecular weight: 266.99664
structure: ChemicalStructure/PW C109074

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 138844
xref: Reference/PubChem-compound 163311989
xref: Reference/KEGG Compound C20246
chemical formula: C7H10NO6PS
molecular weight: 266.99664
structure: ChemicalStructure/PW C109075

4-Amino-5-aminomethyl-2-methylpyrimidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C20267
xref: Reference/PubChem-compound 163312007
chemical formula: C6H10N4
molecular weight: 138.09055
structure: ChemicalStructure/PW C109076

4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 7161
xref: Reference/ChEBI CHEBI 18032
xref: Reference/KEGG Compound C04556
chemical formula: C6H10N3O4P
molecular weight: 219.0409
structure: ChemicalStructure/PW C109077

4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 7322
xref: Reference/KEGG Compound C04752
xref: Reference/ChEBI CHEBI 16629
chemical formula: C6H11N3O7P2
molecular weight: 299.00723
structure: ChemicalStructure/PW C109078

4-Methyl-5-(2-phosphooxyethyl)thiazole
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6980
xref: Reference/ChEBI CHEBI 17857
xref: Reference/KEGG Compound C04327
chemical formula: C6H10NO4PS
molecular weight: 223.00682
structure: ChemicalStructure/PW C109079

Unknown
type: ProteinReference

Reference/PubChem-compound 7322
type: UnificationXref
id: 7322
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
cellular location: Chloroplast
entity reference: S-Adenosylmethionine

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

ADP-5-ethyl-4-methylthiazole-2-carboxylate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C20784
xref: Reference/PubChem-compound 254741251
xref: Reference/ChEBI CHEBI 134399
chemical formula: C17H22N6O12P2S
molecular weight: 596.0492
structure: ChemicalStructure/PW C109080

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Compound/PW C001679 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine monophosphate
stoichiometric coefficient: 1.0

N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C19872
xref: Reference/PubChem-compound 135626338
xref: Reference/ChEBI CHEBI 85895
chemical formula: C7H10N4O
molecular weight: 166.08546
structure: ChemicalStructure/PW C109084

Thiamine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Thiamine monophosphate

Thiamine pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Thiamine pyrophosphate

Carbon monoxide
type: SmallMolecule
cellular location: Chloroplast
entity reference: Carbon monoxide

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Reference/PubChem-compound 163312007
type: UnificationXref
id: 163312007
db: PubChem-compound

Reference/ChEBI CHEBI 18032
type: UnificationXref
id: CHEBI:18032
db: ChEBI

Compound/PW C109079 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Methyl-5-(2-phosphooxyethyl)thiazole
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00153
type: UnificationXref
id: C00153
db: KEGG Compound

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/PubChem-compound 511
type: UnificationXref
id: 511
db: PubChem-compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001235
type: UnificationXref
id: HMDB0001235
db: HMDB

Reference/ChEBI CHEBI 9532
type: UnificationXref
id: CHEBI:9532
db: ChEBI

Reference/ChEBI CHEBI 9534
type: UnificationXref
id: CHEBI:9534
db: ChEBI

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

TransportCatalysis2036
type: Catalysis
controller: Unknown
controlled: Transport10866
control type: ACTIVATION

Reference/UniProt Q9ASY9
type: UnificationXref
id: Q9ASY9
db: UniProt

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/BioCyc NIACINAMIDE
type: UnificationXref
id: NIACINAMIDE
db: BioCyc

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000158
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N

Compound/PW C109076 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Amino-5-aminomethyl-2-methylpyrimidine
stoichiometric coefficient: 1.0

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/SMPDB SMP0122669
type: UnificationXref
id: SMP0122669
db: SMPDB

ChemicalStructure/PW C108886
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001361
type: UnificationXref
id: HMDB0001361
db: HMDB

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/PubChem-compound 777
type: UnificationXref
id: 777
db: PubChem-compound

Reference/ChEBI CHEBI 18385
type: UnificationXref
id: CHEBI:18385
db: ChEBI

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/CAS 630-08-0
type: UnificationXref
id: 630-08-0
db: CAS

Reference/KEGG Compound C00068
type: UnificationXref
id: C00068
db: KEGG Compound

Compound/PW C001060 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/PathWhiz PW123985
type: UnificationXref
id: PW123985
db: PathWhiz

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

TransportCatalysis2044
type: Catalysis
controller: Unknown
controlled: Transport10874
control type: ACTIVATION

Reference/HMDB HMDB0001372
type: UnificationXref
id: HMDB0001372
db: HMDB

Compound/Generic607 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: [ADP-thiazole synthase]-L-cysteine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Thiamine Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2461595
pathway order: PathwayEnzymeReaction/2461594
pathway order: PathwayTransport/2461597
pathway order: PathwaySubPathway/112838
pathway order: PathwayEnzymeReaction/2461513
pathway order: PathwayEnzymeReaction/2461601
pathway order: PathwayEnzymeReaction/2461514
pathway order: PathwayTransport/2461596
pathway order: PathwayEnzymeReaction/2461679
pathway order: PathwayEnzymeReaction/2461599
pathway order: PathwayEnzymeReaction/2461600
pathway order: PathwayEnzymeReaction/2461598
pathway order: PathwayEnzymeReaction/2461508
pathway order: PathwayEnzymeReaction/2461509
pathway order: PathwayEnzymeReaction/2461507
pathway component: ReactionCatalysis202717
pathway component: ReactionCatalysis202712
pathway component: ReactionCatalysis202711
pathway component: TransportCatalysis2036
pathway component: ReactionCatalysis202713
pathway component: 3.1.3.100,3.5.99.2
pathway component: 3.5.1.-,3.5.99.2
pathway component: 2.5.1.3,2.7.1.49
pathway component: Transport10866
pathway component: 2.7.1.50
pathway component: 2.7.6.2
pathway component: Purine Metabolism
pathway component: 2.7.4.3
pathway component: Reaction213092
pathway component: 2.4.2.60
pathway component: ReactionCatalysis202709
pathway component: ReactionCatalysis202708
pathway component: ReactionCatalysis202705
pathway component: ReactionCatalysis202704
pathway component: ReactionCatalysis202707
pathway component: ReactionCatalysis202706
pathway component: ReactionCatalysis202703
pathway component: ReactionCatalysis202702
pathway component: Reaction213097
pathway component: Transport10874
pathway component: 4.1.99.17
pathway component: TransportCatalysis2044
xref: Reference/PathWhiz PW123985
xref: Reference/SMPDB SMP0122669
organism: Arabidopsis thaliana

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/KEGG Compound C04556
type: UnificationXref
id: C04556
db: KEGG Compound

Thiamine monophosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 2627905
xref: Reference/HMDB HMDB0002666
xref: Reference/KEGG Compound C01081
xref: Reference/BioCyc THIAMINE-P
xref: Reference/PubChem-compound 3382778
xref: Reference/ChEBI CHEBI 37574
xref: Reference/CAS 495-23-8
chemical formula: C12H17N4O4PS
molecular weight: 344.0708
structure: ChemicalStructure/PW C001679

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

5-Aminoimidazole ribonucleotide
type: SmallMolecule
cellular location: Chloroplast
entity reference: 5-Aminoimidazole ribonucleotide

Compound/PW C043231 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

ChemicalStructure/PW C001060
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/KEGG Compound C04327
type: UnificationXref
id: C04327
db: KEGG Compound

5'-Deoxyadenosine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05198
xref: Reference/ChemSpider 388325
xref: Reference/CAS 4754-39-6
xref: Reference/HMDB HMDB0001983
xref: Reference/ChEBI CHEBI 17319
xref: Reference/BioCyc CH33ADO
xref: Reference/PubChem-compound 439182
chemical formula: C10H13N5O3
molecular weight: 251.10184
structure: ChemicalStructure/PW C001329

Transport10874
type: Transport
participant stoichiometry: Compound/PW C043231 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043231 Chloroplast/Stoichiometry/1.0
right: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
spontaneous: false
left: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
name: 4-Amino-5-hydroxymethyl-2-methylpyrimidine (→) Transport: Arabidopsis thaliana, Cell, Cytoplasm to Arabidopsis thaliana, Cell, Chloroplast
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 1104
type: UnificationXref
id: 1104
db: ChemSpider

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Thiamine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Thiamine triphosphate

Transport10866
type: Transport
participant stoichiometry: Compound/PW C001679 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001679 Cytosol/Stoichiometry/1.0
right: Thiamine monophosphate
spontaneous: false
left: Thiamine monophosphate
name: Thiamine monophosphate (→) Transport: Arabidopsis thaliana, Cell, Chloroplast to Arabidopsis thaliana, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/ChemSpider 1100
type: UnificationXref
id: 1100
db: ChemSpider

Purine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112838
pathway component: SubPathwayInteraction112838
xref: Reference/SMPDB SMP0122640
xref: Reference/PathWhiz PW123955
name: SubPathway

ChemicalStructure/PW C001165
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C03373
type: UnificationXref
id: C03373
db: KEGG Compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

SubPathwayInteraction112838
type: Interaction
name: SubPathwayReaction
name: SubPathway112838Reaction

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 7161
type: UnificationXref
id: 7161
db: PubChem-compound

Reference/CAS 25635-88-5
type: UnificationXref
id: 25635-88-5
db: CAS

Reference/KEGG Compound C04752
type: UnificationXref
id: C04752
db: KEGG Compound

Reference/UniProt Q6ID68
type: UnificationXref
id: Q6ID68
db: UniProt

Reference/KEGG Compound C01081
type: UnificationXref
id: C01081
db: KEGG Compound

Formic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Formic acid

5'-Deoxyadenosine
type: SmallMolecule
cellular location: Chloroplast
entity reference: 5'-Deoxyadenosine

ChemicalStructure/PW C001050
type: ChemicalStructure
structure format: SMILES
structure data: [C-]#[O+]

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Reference/KEGG Compound C03028
type: UnificationXref
id: C03028
db: KEGG Compound

Reference/PubChem-compound 1136
type: UnificationXref
id: 1136
db: PubChem-compound

Reference/PubChem-compound 1130
type: UnificationXref
id: 1130
db: PubChem-compound

Reference/PubChem-compound 1132
type: UnificationXref
id: 1132
db: PubChem-compound

Reference/HMDB HMDB0001983
type: UnificationXref
id: HMDB0001983
db: HMDB

Reference/ChemSpider 496
type: UnificationXref
id: 496
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Thiamine thiazole synthase, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Thiamine thiazole synthase, chloroplastic

Thiamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000235
xref: Reference/CAS 59-43-8
xref: Reference/BioCyc THIAMINE
xref: Reference/ChEBI CHEBI 18385
xref: Reference/PubChem-compound 1130
xref: Reference/KEGG Compound C00378
xref: Reference/ChemSpider 1098
chemical formula: C12H17N4OS
molecular weight: 265.1123
structure: ChemicalStructure/PW C000158

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C001679 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000092 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Unknown
type: Protein
entity reference: Unknown

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/HMDB HMDB0001512
type: UnificationXref
id: HMDB0001512
db: HMDB

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

L-Methionine
type: SmallMolecule
cellular location: Chloroplast
entity reference: L-Methionine

Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Thiamine monophosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Thiamine monophosphate

Phosphomethylpyrimidine synthase, chloroplastic
type: Protein
cellular location: Chloroplast
entity reference: Phosphomethylpyrimidine synthase, chloroplastic

Reference/KEGG Compound C19872
type: UnificationXref
id: C19872
db: KEGG Compound

Reference/BioCyc THIAMINE-P
type: UnificationXref
id: THIAMINE-P
db: BioCyc

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/ChemSpider 275
type: UnificationXref
id: 275
db: ChemSpider

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/CAS 495-23-8
type: UnificationXref
id: 495-23-8
db: CAS

[ADP-thiazole synthase]-dehydroalanine
type: SmallMolecule
cellular location: Chloroplast
entity reference: [ADP-thiazole synthase]-dehydroalanine

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/HMDB HMDB0001406
type: UnificationXref
id: HMDB0001406
db: HMDB

[ADP-thiazole synthase]-L-cysteine
type: SmallMolecule
cellular location: Chloroplast
entity reference: [ADP-thiazole synthase]-L-cysteine

Reference/CAS 3475-65-8
type: UnificationXref
id: 3475-65-8
db: CAS

Reference/PubChem-compound 1023
type: UnificationXref
id: 1023
db: PubChem-compound

Reference/UniProt Q9FK35
type: UnificationXref
id: Q9FK35
db: UniProt

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/SMPDB SMP0122640
type: UnificationXref
id: SMP0122640
db: SMPDB

Compound/PW C001034 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CH33ADO
type: UnificationXref
id: CH33ADO
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Chloroplast
entity reference: Carbon dioxide

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/ChEBI CHEBI 28843
type: UnificationXref
id: CHEBI:28843
db: ChEBI

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

Thiamine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 511
xref: Reference/BioCyc CPD-611
xref: Reference/HMDB HMDB0001512
xref: Reference/ChemSpider 496
xref: Reference/ChEBI CHEBI 9534
xref: Reference/KEGG Compound C03028
xref: Reference/CAS 3475-65-8
chemical formula: C12H20N4O10P3S
molecular weight: 505.0113
structure: ChemicalStructure/PW C001165

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/CAS 137-00-8
type: UnificationXref
id: 137-00-8
db: CAS

Reference/KEGG Compound C20784
type: UnificationXref
id: C20784
db: KEGG Compound

Compound/PW C001086 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Niacinamide
stoichiometric coefficient: 1.0

Diphosphoric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 29888
xref: Reference/CAS 2466-09-3
xref: Reference/KEGG Compound C00013
xref: Reference/PubChem-compound 1023
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C108886

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Thiamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Thiamine

Reference/CAS 4754-39-6
type: UnificationXref
id: 4754-39-6
db: CAS

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/ChEBI CHEBI 17957
type: UnificationXref
id: CHEBI:17957
db: ChEBI

Compound/PW C109077 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Diphosphoric acid
type: SmallMolecule
cellular location: Chloroplast
entity reference: Diphosphoric acid

Compound/PW C001679 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine monophosphate
stoichiometric coefficient: 1.0

[ADP-thiazole synthase]-L-cysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C02743

[ADP-thiazole synthase]-dehydroalanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C21861

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/KEGG Compound C04294
type: UnificationXref
id: C04294
db: KEGG Compound

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Compound/PW C000548 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Carbon monoxide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00237
xref: Reference/ChemSpider 275
xref: Reference/PubChem-compound 281
xref: Reference/HMDB HMDB0001361
xref: Reference/ChEBI CHEBI 17245
xref: Reference/CAS 630-08-0
chemical formula: CO
molecular weight: 27.994915
structure: ChemicalStructure/PW C001050

Compound/PW C109080 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: ADP-5-ethyl-4-methylthiazole-2-carboxylate
stoichiometric coefficient: 1.0

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

ChemicalStructure/PW C001679
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCOP(O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/HMDB HMDB0000235
type: UnificationXref
id: HMDB0000235
db: HMDB

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

4-Amino-5-hydroxymethyl-2-methylpyrimidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 4-Amino-5-hydroxymethyl-2-methylpyrimidine

Reference/UniProt B9DGU7
type: UnificationXref
id: B9DGU7
db: UniProt

Reference/KEGG Compound C21861
type: UnificationXref
id: C21861
db: KEGG Compound

ChemicalStructure/PW C001329
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Reference/HMDB HMDB0002666
type: UnificationXref
id: HMDB0002666
db: HMDB

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Water
type: SmallMolecule
cellular location: Chloroplast
entity reference: Water

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine

Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
type: UnificationXref
id: 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
db: BioCyc

5-(2-Hydroxyethyl)-4-methylthiazole
type: SmallMolecule
entity reference: 5-(2-Hydroxyethyl)-4-methylthiazole

Compound/PW C001329 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Deoxyadenosine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 161500
type: UnificationXref
id: 161500
db: PubChem-compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16892
type: UnificationXref
id: CHEBI:16892
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Niacinamide
type: SmallMoleculeReference
xref: Reference/CAS 98-92-0
xref: Reference/HMDB HMDB0001406
xref: Reference/KEGG Compound C00153
xref: Reference/PubChem-compound 936
xref: Reference/BioCyc NIACINAMIDE
xref: Reference/ChemSpider 911
xref: Reference/ChEBI CHEBI 17154
chemical formula: C6H6N2O
molecular weight: 122.04801
structure: ChemicalStructure/PW C001086

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000158 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

Reference/BioCyc 2-(alpha-lactyl)-thpp
type: UnificationXref
id: 2-(alpha-lactyl)-thpp
db: BioCyc

Reference/ChEBI CHEBI 138844
type: UnificationXref
id: CHEBI:138844
db: ChEBI

Reference/CAS 59-43-8
type: UnificationXref
id: 59-43-8
db: CAS

Compound/PW C001420 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

4.1.99.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001329 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109077 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001050 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000955 Chloroplast/Stoichiometry/1.0
right: Formic acid
right: 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate
right: Carbon monoxide
right: L-Methionine
right: 5'-Deoxyadenosine
spontaneous: false
EC number: 4.1.99.17
left: S-Adenosylmethionine
left: 5-Aminoimidazole ribonucleotide
name: 5-Aminoimidazole ribonucleotide + S-Adenosylmethionine → 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'-Deoxyadenosine + Carbon monoxide + Formic acid + L-Methionine
conversion direction: LEFT_TO_RIGHT

2.5.1.3,2.7.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109077 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109078 Chloroplast/Stoichiometry/1.0
right: 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.5.1.3,2.7.1.49
left: Adenosine triphosphate
left: 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate
name: 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate + Adenosine triphosphate → 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

2.5.1.3,2.7.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C109074 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109075 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109079 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001679 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108886 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109078 Chloroplast/Stoichiometry/1.0
right: Diphosphoric acid
right: Carbon dioxide
right: Thiamine monophosphate
spontaneous: false
EC number: 2.5.1.3,2.7.1.49
left: 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
left: 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
left: 4-Methyl-5-(2-phosphooxyethyl)thiazole
left: 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
name: 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 4-Methyl-5-(2-phosphooxyethyl)thiazole → Carbon dioxide + Diphosphoric acid + Thiamine monophosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

ChemicalStructure/PW C043231
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CO)C(N)=N1

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C108886 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diphosphoric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 85895
type: UnificationXref
id: CHEBI:85895
db: ChEBI

Reference/ChemSpider 2627905
type: UnificationXref
id: 2627905
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

3.1.3.100,3.5.99.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000158 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001679 Cytoplasm/Stoichiometry/1.0
right: Thiamine
right: Phosphate
spontaneous: false
EC number: 3.1.3.100,3.5.99.2
left: Thiamine monophosphate
left: Water
name: Thiamine monophosphate + Water → Phosphate + Thiamine
conversion direction: LEFT_TO_RIGHT

3.5.1.-,3.5.99.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109076 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043231 Cytoplasm/Stoichiometry/1.0
right: Ammonia
right: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
spontaneous: false
EC number: 3.5.1.-,3.5.99.2
left: 4-Amino-5-aminomethyl-2-methylpyrimidine
left: Water
name: 4-Amino-5-aminomethyl-2-methylpyrimidine + Water → 4-Amino-5-hydroxymethyl-2-methylpyrimidine + Ammonia
conversion direction: LEFT_TO_RIGHT

2.5.1.3,2.7.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109077 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043231 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Chloroplast/Stoichiometry/1.0
right: 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.5.1.3,2.7.1.49
left: Adenosine triphosphate
left: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
name: 4-Amino-5-hydroxymethyl-2-methylpyrimidine + Adenosine triphosphate → 4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

2.7.1.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109079/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C014066/Stoichiometry/1.0
right: Adenosine diphosphate
right: 4-Methyl-5-(2-phosphooxyethyl)thiazole
spontaneous: false
EC number: 2.7.1.50
left: 5-(2-Hydroxyethyl)-4-methylthiazole
left: Adenosine triphosphate
name: 5-(2-Hydroxyethyl)-4-methylthiazole + Adenosine triphosphate → 4-Methyl-5-(2-phosphooxyethyl)thiazole + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

2.7.6.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000158 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Thiamine pyrophosphate
spontaneous: false
EC number: 2.7.6.2
left: Adenosine triphosphate
left: Thiamine
name: Adenosine triphosphate + Thiamine → Adenosine monophosphate + Thiamine pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 37574
type: UnificationXref
id: CHEBI:37574
db: ChEBI

Reference/ChEBI CHEBI 134399
type: UnificationXref
id: CHEBI:134399
db: ChEBI

Reference/KEGG Compound C05198
type: UnificationXref
id: C05198
db: KEGG Compound

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Compound/PW C109079/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Methyl-5-(2-phosphooxyethyl)thiazole
stoichiometric coefficient: 1.0

2.7.4.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001165 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Thiamine triphosphate
spontaneous: false
EC number: 2.7.4.3
left: Adenosine monophosphate
left: Thiamine pyrophosphate
name: Adenosine monophosphate + Thiamine pyrophosphate → Thiamine triphosphate
conversion direction: LEFT_TO_RIGHT

Reaction213092
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001679 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060 Cytoplasm/Stoichiometry/1.0
right: Thiamine monophosphate
right: Phosphate
spontaneous: false
left: Water
left: Thiamine pyrophosphate
name: Thiamine pyrophosphate + Water → Phosphate + Thiamine monophosphate
conversion direction: LEFT_TO_RIGHT

2.4.2.60
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/Generic608 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001086 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109080 Chloroplast/Stoichiometry/1.0
participant stoichiometry: Compound/Generic607 Chloroplast/Stoichiometry/1.0
right: Niacinamide
right: [ADP-thiazole synthase]-dehydroalanine
right: Water
right: ADP-5-ethyl-4-methylthiazole-2-carboxylate
spontaneous: false
EC number: 2.4.2.60
left: Glycine
left: NAD
left: [ADP-thiazole synthase]-L-cysteine
name: Glycine + NAD + [ADP-thiazole synthase]-L-cysteine → ADP-5-ethyl-4-methylthiazole-2-carboxylate + Niacinamide + Water + [ADP-thiazole synthase]-dehydroalanine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16629
type: UnificationXref
id: CHEBI:16629
db: ChEBI

Thiamine pyrophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc 2-(alpha-lactyl)-thpp
xref: Reference/ChEBI CHEBI 9532
xref: Reference/CAS 154-87-0
xref: Reference/ChemSpider 1100
xref: Reference/HMDB HMDB0001372
xref: Reference/PubChem-compound 1132
xref: Reference/KEGG Compound C00068
chemical formula: C12H19N4O7P2S
molecular weight: 425.04498
structure: ChemicalStructure/PW C001060

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Bifunctional TENA-E protein
type: Protein
cellular location: Cytoplasm
entity reference: Bifunctional TENA-E protein

Reference/ChEBI CHEBI 17857
type: UnificationXref
id: CHEBI:17857
db: ChEBI

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 254741251
type: UnificationXref
id: 254741251
db: PubChem-compound

Reaction213097
type: BiochemicalReaction
participant stoichiometry: Compound/PW C109084 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109076 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
right: 4-Amino-5-aminomethyl-2-methylpyrimidine
right: Formic acid
spontaneous: false
left: Water
left: N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
name: N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine + Water → 4-Amino-5-aminomethyl-2-methylpyrimidine + Formic acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 163311989
type: UnificationXref
id: 163311989
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/ChemSpider 1098
type: UnificationXref
id: 1098
db: ChemSpider

ChemicalStructure/PW C000955
type: ChemicalStructure
structure format: SMILES

Formic acid
type: SmallMolecule
cellular location: Chloroplast
entity reference: Formic acid

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/PubChem-compound 6980
type: UnificationXref
id: 6980
db: PubChem-compound

Reference/PubChem-compound 163311990
type: UnificationXref
id: 163311990
db: PubChem-compound

Reference/BioCyc CPD-611
type: UnificationXref
id: CPD-611
db: BioCyc

ReactionCatalysis202717
type: Catalysis
controller: Bifunctional TENA-E protein
controlled: Reaction213097
control type: ACTIVATION

ReactionCatalysis202712
type: Catalysis
controller: At5g66005
controlled: Reaction213092
control type: ACTIVATION

ReactionCatalysis202711
type: Catalysis
controller: Adenylate kinase 3
controlled: 2.7.4.3
control type: ACTIVATION

ReactionCatalysis202713
type: Catalysis
controller: Thiamine thiazole synthase, chloroplastic
controlled: 2.4.2.60
control type: ACTIVATION

Reference/PubChem-compound 281
type: UnificationXref
id: 281
db: PubChem-compound

ChemicalStructure/PW C109074
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCOP(O)(O)=O)SC(=N1)C(O)=O

ChemicalStructure/PW C109075
type: ChemicalStructure
structure format: SMILES
structure data: CC1=N[C@H](S\C1=C/COP(O)(O)=O)C(O)=O

Reference/KEGG Compound C20247
type: UnificationXref
id: C20247
db: KEGG Compound

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C20246
type: UnificationXref
id: C20246
db: KEGG Compound

Compound/Generic608 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: [ADP-thiazole synthase]-dehydroalanine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

ChemicalStructure/PW C109076
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CN)C(N)=N1

ChemicalStructure/PW C109077
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(=N)N1

ChemicalStructure/PW C109078
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(=O)OP(O)(O)=O)C(N)=N1

ChemicalStructure/PW C109079
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCOP(O)(O)=O)SC=N1

ADP-5-ethyl-4-methylthiazole-2-carboxylate
type: SmallMolecule
cellular location: Chloroplast
entity reference: ADP-5-ethyl-4-methylthiazole-2-carboxylate

ReactionCatalysis202709
type: Catalysis
controller: Thiamine pyrophosphokinase 1
controlled: 2.7.6.2
control type: ACTIVATION

ReactionCatalysis202708
type: Catalysis
controller: Hydroxyethylthiazole kinase
controlled: 2.7.1.50
control type: ACTIVATION

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Chloroplast
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0009507

Reference/ChEBI CHEBI 17319
type: UnificationXref
id: CHEBI:17319
db: ChEBI

Compound/PW C000078 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C109084
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CN=CO)C(=N)N1

Compound/PW C043231 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C109080
type: ChemicalStructure
structure format: SMILES

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29888
type: UnificationXref
id: CHEBI:29888
db: ChEBI

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C001316 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Hydroxyethylthiazole kinase
type: Protein
entity reference: Hydroxyethylthiazole kinase

At5g66005
type: Protein
cellular location: Cytoplasm
entity reference: At5g66005

Reference/KEGG Compound C20267
type: UnificationXref
id: C20267
db: KEGG Compound

Thiamine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thiamine monophosphate

Reference/CAS 2466-09-3
type: UnificationXref
id: 2466-09-3
db: CAS

Adenosine diphosphate
type: SmallMolecule
cellular location: Chloroplast
entity reference: Adenosine diphosphate

Adenylate kinase 3
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate kinase 3

Thiamine pyrophosphokinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Thiamine pyrophosphokinase 1

Reference/UniProt Q9LIQ4
type: UnificationXref
id: Q9LIQ4
db: UniProt

ReactionCatalysis202705
type: Catalysis
controller: Bifunctional TH2 protein, mitochondrial
controlled: 3.1.3.100,3.5.99.2
control type: ACTIVATION

ReactionCatalysis202704
type: Catalysis
controller: Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic
controlled: 2.5.1.3,2.7.1.49
control type: ACTIVATION

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCatalysis202707
type: Catalysis
controller: Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic
controlled: 2.5.1.3,2.7.1.49
control type: ACTIVATION

ReactionCatalysis202706
type: Catalysis
controller: Bifunctional TENA-E protein
controlled: 3.5.1.-,3.5.99.2
control type: ACTIVATION

ReactionCatalysis202703
type: Catalysis
controller: Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic
controlled: 2.5.1.3,2.7.1.49
control type: ACTIVATION

ReactionCatalysis202702
type: Catalysis
controller: Phosphomethylpyrimidine synthase, chloroplastic
controlled: 4.1.99.17
control type: ACTIVATION

Reference/BioCyc THIAMINE
type: UnificationXref
id: THIAMINE
db: BioCyc

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

5-(2-Hydroxyethyl)-4-methylthiazole
type: SmallMoleculeReference
xref: Reference/ChemSpider 1104
xref: Reference/CAS 137-00-8
xref: Reference/ChEBI CHEBI 17957
xref: Reference/KEGG Compound C04294
xref: Reference/HMDB HMDB0032985
xref: Reference/PubChem-compound 1136
chemical formula: C6H9NOS
molecular weight: 143.04048
structure: ChemicalStructure/PW C014066

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/CAS 98-92-0
type: UnificationXref
id: 98-92-0
db: CAS

Compound/PW C001050 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon monoxide
stoichiometric coefficient: 1.0

Compound/PW C109078 Chloroplast/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
stoichiometric coefficient: 1.0