Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Transport10965
type: Transport
participant stoichiometry: ProteinComplex/583 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/583 Nucleus/Stoichiometry/1.0
right: Epithelial Sodium Channel
spontaneous: false
left: Epithelial Sodium Channel
name: Epithelial Sodium Channel (→) Transport: Homo sapiens, Kidney, Nucleus to Homo sapiens, Kidney, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10966
type: Transport
participant stoichiometry: ProteinComplex/545 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/545 Cytosol/Stoichiometry/1.0
right: Sodium/potassium ATPase
spontaneous: false
left: Sodium/potassium ATPase
name: Sodium/potassium ATPase (→) Transport: Homo sapiens, Kidney, Nucleus to Homo sapiens, Kidney, Cytosol
conversion direction: LEFT_TO_RIGHT

direct_interaction
type: InteractionVocabulary

TransportCatalysis2091
type: Catalysis
controller: Potassium channel subfamily K member 1
controlled: Transport10930
control type: ACTIVATION

BiologicalState781
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Kidney
tissue: Kidney

Aldosterone
type: SmallMolecule
cellular location: Cytosol
entity reference: Aldosterone

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Eplerenone_Mineralocorticoid receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C009176 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2032 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Mineralocorticoid receptor
component: Eplerenone

Amiloride-sensitive sodium channel subunit delta
type: Protein
cellular location: Nucleus
entity reference: Amiloride-sensitive sodium channel subunit delta

Transport10958
type: Transport
participant stoichiometry: BoundComplex/16 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/16 Nucleus/Stoichiometry/1.0
right: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
spontaneous: false
left: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
name: Active Mineralocorticoid receptor (Homo sapiens) + Aldosterone (→) Transport: Homo sapiens, Kidney, Cytosol to Homo sapiens, Kidney, Nucleus
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

ProteinComplex/545 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium/potassium ATPase
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Compound/PW C000026 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Sodium/potassium ATPase
type: DnaReference
organism: BiologicalState781

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10203511
type: UnificationXref
id: 10203511
db: ChemSpider

Compound/PW C000026 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Sodium/potassium ATPase
type: Complex
cellular location: Cytosol
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-3
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit beta-2

Amiloride-sensitive sodium channel subunit alpha
type: Protein
cellular location: Nucleus
entity reference: Amiloride-sensitive sodium channel subunit alpha

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Aquaporin-3
type: Protein
entity reference: Aquaporin-3

Transport10930
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: true
left: Potassium
name: Potassium (←) Transport: Homo sapiens, Kidney, Cytosol to Homo sapiens, Extracellular Space
conversion direction: REVERSIBLE

Sodium/potassium ATPase
type: Complex
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-3

Reaction213252
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/583 Nucleus/Stoichiometry/1.0
participant stoichiometry: DNA/349 Nucleus/Stoichiometry/1.0
right: Epithelial Sodium Channel
spontaneous: false
left: Epithelial sodium channel
name: Epithelial sodium channel → Epithelial Sodium Channel
conversion direction: LEFT_TO_RIGHT

Reaction213253
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/545 Nucleus/Stoichiometry/1.0
participant stoichiometry: DNA/350 Nucleus/Stoichiometry/1.0
right: Sodium/potassium ATPase
spontaneous: false
left: Sodium/potassium ATPase
name: Sodium/potassium ATPase → Sodium/potassium ATPase
conversion direction: LEFT_TO_RIGHT

ProteinComplex/672 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Amiloride-sensitive sodium channel subunit delta
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit delta

Amiloride-sensitive sodium channel subunit beta
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit beta

Epithelial Sodium Channel
type: Complex
cellular location: Cytosol
component: Amiloride-sensitive sodium channel subunit delta
component: Amiloride-sensitive sodium channel subunit beta
component: Amiloride-sensitive sodium channel subunit gamma
component: Amiloride-sensitive sodium channel subunit alpha

Reference/HMDB HMDB0014838
type: UnificationXref
id: HMDB0014838
db: HMDB

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Reference/UniProt P37088
type: UnificationXref
id: P37088
db: UniProt

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Aquaporin-2
type: Protein
entity reference: Aquaporin-2

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Kidney
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000671

Transport10362
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

ProteinComplex/583 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epithelial Sodium Channel
stoichiometric coefficient: 1.0

Amiloride-sensitive sodium channel subunit beta
type: Protein
cellular location: Cytosol
entity reference: Amiloride-sensitive sodium channel subunit beta

TransportCatalysis1532
type: Catalysis
controller: Aquaporin-2
controlled: Transport10362
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Transport53
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport55
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Transport62
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
cellular location: Cytosol
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

Mineralocorticoid receptor
type: Protein
cellular location: Cytosol
entity reference: Mineralocorticoid receptor

Amiloride-sensitive sodium channel subunit alpha
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit alpha

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChEBI CHEBI 31547
type: UnificationXref
id: CHEBI:31547
db: ChEBI

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Reference/SMPDB SMP0122731
type: UnificationXref
id: SMP0122731
db: SMPDB

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Epithelial Sodium Channel
type: Complex
component: Amiloride-sensitive sodium channel subunit gamma
component: Amiloride-sensitive sodium channel subunit delta
component: Amiloride-sensitive sodium channel subunit beta
component: Amiloride-sensitive sodium channel subunit alpha

Amiloride-sensitive sodium channel subunit gamma
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit gamma

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
type: Complex
component stoichiometry: ProteinComplex/672 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C000026 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aldosterone
component: Active Mineralocorticoid receptor

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

ChemicalStructure/PW C009176
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Sodium/potassium ATPase
type: Complex
cellular location: Nucleus
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-3
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: Sodium/potassium-transporting ATPase subunit alpha-4

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

BoundComplex/16 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
stoichiometric coefficient: 1.0

Reference/UniProt P08235
type: UnificationXref
id: P08235
db: UniProt

Amiloride-sensitive sodium channel subunit delta
type: ProteinReference
xref: Reference/UniProt P51172

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026

Reference/UniProt P41181
type: UnificationXref
id: P41181
db: UniProt

Aquaporin-3
type: ProteinReference
xref: Reference/UniProt Q92482

Amiloride-sensitive sodium channel subunit beta
type: ProteinReference
xref: Reference/UniProt P51168

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415

ProteinComplex/583 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epithelial Sodium Channel
stoichiometric coefficient: 1.0

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Sodium/potassium ATPase
type: Dna
cellular location: Nucleus
entity reference: Sodium/potassium ATPase

Potassium channel subfamily K member 1
type: Protein
entity reference: Potassium channel subfamily K member 1

Reference/CAS 107724-20-9
type: UnificationXref
id: 107724-20-9
db: CAS

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Amiloride-sensitive sodium channel subunit gamma
type: Protein
cellular location: Nucleus
entity reference: Amiloride-sensitive sodium channel subunit gamma

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

TransportCatalysis23
type: Catalysis
controller: Sodium/potassium ATPase
controlled: Transport53
control type: ACTIVATION

Aquaporin-2
type: ProteinReference
xref: Reference/UniProt P41181

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Reference/UniProt Q92482
type: UnificationXref
id: Q92482
db: UniProt

Reference/PathWhiz PW124055
type: UnificationXref
id: PW124055
db: PathWhiz

DNA/349 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Epithelial sodium channel
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Aldosterone
type: SmallMolecule
cellular location: Nucleus
entity reference: Aldosterone

Epithelial sodium channel
type: Dna
cellular location: Nucleus
entity reference: Epithelial sodium channel

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

TransportCatalysis33
type: Catalysis
controller: Epithelial Sodium Channel
controlled: Transport62
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

TransportCatalysis32
type: Catalysis
controller: Aquaporin-3
controlled: Transport55
control type: ACTIVATION

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023

Interaction3242
type: MolecularInteraction
interaction type: direct_interaction
name: Eplerenone + Mineralocorticoid receptor (Homo sapiens) inhibits Active Mineralocorticoid receptor (Homo sapiens) + Aldosterone
participant: Eplerenone_Mineralocorticoid receptor (Homo sapiens)
participant: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Interaction3249
type: MolecularInteraction
interaction type: direct_interaction
name: Active Mineralocorticoid receptor (Homo sapiens) + Aldosterone activates Epithelial sodium channel
participant: Epithelial sodium channel
participant: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone

Amiloride-sensitive sodium channel subunit beta
type: Protein
cellular location: Nucleus
entity reference: Amiloride-sensitive sodium channel subunit beta

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Active Mineralocorticoid receptor
type: Complex
component stoichiometry: Protein/2032 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Mineralocorticoid receptor

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Eplerenone
type: SmallMolecule
cellular location: Cytosol
entity reference: Eplerenone

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Amiloride-sensitive sodium channel subunit alpha
type: ProteinReference
xref: Reference/UniProt P37088

Eplerenone Action Pathway
type: Pathway
pathway order: PathwayTransport/2462757
pathway order: PathwayTransport/2462768
pathway order: PathwayInteraction/3250
pathway order: PathwayTransport/2462756
pathway order: PathwayTransport/2462748
pathway order: PathwayTransport/2462764
pathway order: PathwayTransport/2462831
pathway order: PathwayTransport/2462762
pathway order: PathwayEnzymeReaction/2462829
pathway order: PathwayEnzymeReaction/2462827
pathway order: PathwayInteraction/3249
pathway order: PathwayInteraction/3242
pathway order: PathwayTransport/2462828
pathway component: TransportCatalysis1532
pathway component: Interaction3250
pathway component: Transport10958
pathway component: Transport10930
pathway component: TransportCatalysis23
pathway component: TransportCatalysis33
pathway component: Reaction213252
pathway component: Transport10965
pathway component: TransportCatalysis32
pathway component: Reaction213253
pathway component: Transport10966
pathway component: Transport53
pathway component: Interaction3242
pathway component: Transport55
pathway component: Transport10362
pathway component: Transport62
pathway component: TransportCatalysis2091
pathway component: Interaction3249
xref: Reference/SMPDB SMP0122731
xref: Reference/PathWhiz PW124055
organism: Homo sapiens

ProteinComplex/672 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor
stoichiometric coefficient: 1.0

Epithelial Sodium Channel
type: Complex
cellular location: Nucleus
component: Amiloride-sensitive sodium channel subunit alpha
component: Amiloride-sensitive sodium channel subunit beta
component: Amiloride-sensitive sodium channel subunit delta
component: Amiloride-sensitive sodium channel subunit gamma

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Mineralocorticoid receptor
type: ProteinReference
xref: Reference/UniProt P08235
organism: BiologicalState781

Amiloride-sensitive sodium channel subunit gamma
type: ProteinReference
xref: Reference/UniProt P51170

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Amiloride-sensitive sodium channel subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Amiloride-sensitive sodium channel subunit alpha

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
type: Complex
component stoichiometry: ProteinComplex/672 Cytosol/Stoichiometry/1.0
component stoichiometry: Compound/PW C000026 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Aldosterone
component: Active Mineralocorticoid receptor

Active Mineralocorticoid receptor
type: Complex
component stoichiometry: Protein/2032 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Mineralocorticoid receptor

Protein/2032 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Mineralocorticoid receptor
stoichiometric coefficient: 2.0

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
cellular location: Nucleus
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Interaction3250
type: MolecularInteraction
interaction type: direct_interaction
name: Active Mineralocorticoid receptor (Homo sapiens) + Aldosterone activates Sodium/potassium ATPase
participant: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
participant: Sodium/potassium ATPase

ProteinComplex/545 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium/potassium ATPase
stoichiometric coefficient: 1.0

Epithelial sodium channel
type: DnaReference
organism: BiologicalState781

Reference/PubChem-compound 443872
type: UnificationXref
id: 443872
db: PubChem-compound

DNA/350 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium/potassium ATPase
stoichiometric coefficient: 1.0

Amiloride-sensitive sodium channel subunit gamma
type: Protein
cellular location: Cytosol
entity reference: Amiloride-sensitive sodium channel subunit gamma

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Potassium channel subfamily K member 1
type: ProteinReference

Eplerenone
type: SmallMoleculeReference
xref: Reference/ChemSpider 10203511
xref: Reference/ChEBI CHEBI 31547
xref: Reference/HMDB HMDB0014838
xref: Reference/PubChem-compound 443872
xref: Reference/CAS 107724-20-9
xref: Reference/KEGG Compound C12512
chemical formula: C24H30O6
molecular weight: 414.20422
structure: ChemicalStructure/PW C009176

BoundComplex/16 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
stoichiometric coefficient: 1.0

Compound/PW C009176 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Eplerenone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Protein/2032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mineralocorticoid receptor
stoichiometric coefficient: 1.0

Amiloride-sensitive sodium channel subunit delta
type: Protein
cellular location: Cytosol
entity reference: Amiloride-sensitive sodium channel subunit delta

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Reference/UniProt P51168
type: UnificationXref
id: P51168
db: UniProt

Reference/KEGG Compound C12512
type: UnificationXref
id: C12512
db: KEGG Compound

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/UniProt P51172
type: UnificationXref
id: P51172
db: UniProt

Reference/UniProt P51170
type: UnificationXref
id: P51170
db: UniProt

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Protein/2032 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Mineralocorticoid receptor
stoichiometric coefficient: 2.0

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
cellular location: Cytosol
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Reference/BRENDA TISSUE ONTOLOGY BTO 0000671
type: UnificationXref
id: BTO:0000671
db: BRENDA TISSUE ONTOLOGY

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
cellular location: Nucleus
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Mineralocorticoid receptor
type: Protein
cellular location: Nucleus
entity reference: Mineralocorticoid receptor

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0