Phenylacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phenylacetic acid

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/PubChem-compound 6140
type: UnificationXref
id: 6140
db: PubChem-compound

Reference/SMPDB SMP0123256
type: UnificationXref
id: SMP0123256
db: SMPDB

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

SubPathwayControl118434
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway118434Control
participant: Inflammation by priming polymorphonuclear leucocytes.
participant: Phenylacetic acid

Reference/CAS 63-91-2
type: UnificationXref
id: 63-91-2
db: CAS

Reference/UniProt P08195
type: UnificationXref
id: P08195
db: UniProt

Reference/KEGG Compound C05332
type: UnificationXref
id: C05332
db: KEGG Compound

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/TAXONOMY 83333
type: UnificationXref
id: 83333
db: TAXONOMY

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0042597
type: UnificationXref
id: GO:0042597
db: GENE ONTOLOGY

Reference/PubChem-compound 1001
type: UnificationXref
id: 1001
db: PubChem-compound

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Ammonium
type: SmallMolecule
cellular location: Periplasm
entity reference: Ammonium

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState60

Reference/KEGG Compound C07086
type: UnificationXref
id: C07086
db: KEGG Compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChemSpider 13876539
type: UnificationXref
id: 13876539
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

4F2 cell-surface antigen heavy chain
type: Protein
entity reference: 4F2 cell-surface antigen heavy chain

Oxygen
type: SmallMolecule
cellular location: Periplasm
entity reference: Oxygen

Compound/PW C007816 Periplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylethylamine
stoichiometric coefficient: 1.0

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Y+L amino acid transporter 1
type: Protein
entity reference: Y+L amino acid transporter 1

Phenylacetic acid
type: SmallMoleculeReference
xref: Reference/BioCyc PHENYLACETATE
xref: Reference/PubChem-compound 999
xref: Reference/ChEBI CHEBI 30745
xref: Reference/KEGG Compound C07086
xref: Reference/HMDB HMDB0000209
xref: Reference/CAS 103-82-2
xref: Reference/ChemSpider 10181341
chemical formula: C8H8O2
molecular weight: 136.05243
structure: ChemicalStructure/PW C000135

Reference/BRENDA TISSUE ONTOLOGY BTO 0000648
type: UnificationXref
id: BTO:0000648
db: BRENDA TISSUE ONTOLOGY

Reference/BioCyc HYDRPHENYLAC-CPD
type: UnificationXref
id: HYDRPHENYLAC-CPD
db: BioCyc

copper-containing amine oxidase
type: Complex
component stoichiometry: Protein/6636 Periplasm/Stoichiometry/2.0
cellular location: Periplasm
component: Primary amine oxidase

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C000104/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Phenylalanine
stoichiometric coefficient: 1.0

SLC3A2/4F2hc Y+L amino acid transporter 1
type: Complex
component: Y+L amino acid transporter 1
component: 4F2 cell-surface antigen heavy chain

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Phenylacetaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00601
xref: Reference/ChEBI CHEBI 16424
xref: Reference/ChemSpider 13876539
xref: Reference/PubChem-compound 998
xref: Reference/HMDB HMDB0006236
xref: Reference/CAS 122-78-1
xref: Reference/BioCyc HYDRPHENYLAC-CPD
chemical formula: C8H8O
molecular weight: 120.05752
structure: ChemicalStructure/PW C002680

Excitatory amino acid transporter 3
type: Protein
entity reference: Excitatory amino acid transporter 3

Compound/PW C002680 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylacetaldehyde
stoichiometric coefficient: 1.0

Compound/PW C001783 Periplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Phenylacetaldehyde dehydrogenase
type: ProteinReference
xref: Reference/UniProt P80668
organism: BiologicalState238

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Phenylethylamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05332
xref: Reference/CAS 64-04-0
xref: Reference/BioCyc PHENYLETHYLAMINE
xref: Reference/ChemSpider 13856352
xref: Reference/HMDB HMDB0012275
xref: Reference/ChEBI CHEBI 18397
xref: Reference/PubChem-compound 1001
chemical formula: C8H11N
molecular weight: 121.08915
structure: ChemicalStructure/PW C007816

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/HMDB HMDB0000209
type: UnificationXref
id: HMDB0000209
db: HMDB

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C000135
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CC=CC=C1

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Inflammation by priming polymorphonuclear leucocytes.
type: Pathway
name: ActivatingSubPathway

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C001420 Periplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

BiologicalState238
type: BioSource
xref: Reference/TAXONOMY 83333
name: Escherichia coli (strain K12)

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Intestine
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000648

ChemicalStructure/PW C002680
type: ChemicalStructure
structure format: SMILES
structure data: O=CCC1=CC=CC=C1

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

ChemicalStructure/PW C000104
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=CC=C1)C(O)=O

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Unknown
type: Protein
entity reference: Unknown

Reference/BioCyc PHENYLACETATE
type: UnificationXref
id: PHENYLACETATE
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

phenylacetaldehyde dehydrogenase
type: Complex
component stoichiometry: Protein/6808 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Phenylacetaldehyde dehydrogenase

4F2 cell-surface antigen heavy chain
type: ProteinReference
xref: Reference/UniProt P08195

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Y+L amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt Q9UM01

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/ChemSpider 13856352
type: UnificationXref
id: 13856352
db: ChemSpider

Phenylethylamine
type: SmallMolecule
entity reference: Phenylethylamine

Compound/PW C002680 Periplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylacetaldehyde
stoichiometric coefficient: 1.0

Periplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042597

TransportCatalysis5354
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 1
controlled: Transport14539
control type: ACTIVATION

TransportCatalysis5352
type: Catalysis
controller: Unknown
controlled: Transport14538
control type: ACTIVATION

TransportCatalysis5353
type: Catalysis
controller: Excitatory amino acid transporter 3
controlled: Transport14539
control type: ACTIVATION

BiologicalState60
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Intestine
tissue: Intestine

TransportCatalysis5350
type: Catalysis
controller: Unknown
controlled: Transport14536
control type: ACTIVATION

TransportCatalysis5351
type: Catalysis
controller: Unknown
controlled: Transport14537
control type: ACTIVATION

Compound/PW C001065 Periplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/UniProt P80668
type: UnificationXref
id: P80668
db: UniProt

Compound/PW C022608 Periplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18397
type: UnificationXref
id: CHEBI:18397
db: ChEBI

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Excitatory amino acid transporter 3
type: ProteinReference
xref: Reference/UniProt P43005

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/UniProt P43005
type: UnificationXref
id: P43005
db: UniProt

ReactionCatalysis5882
type: Catalysis
controller: phenylacetaldehyde dehydrogenase
controlled: 1.2.1.39
control type: ACTIVATION

ReactionCatalysis5881
type: Catalysis
controller: copper-containing amine oxidase
controlled: 1.4.3.21
control type: ACTIVATION

Reference/HMDB HMDB0006236
type: UnificationXref
id: HMDB0006236
db: HMDB

Reference/ChemSpider 10181341
type: UnificationXref
id: 10181341
db: ChemSpider

SubPathwayInteraction113827
type: Interaction
name: SubPathway113827Reaction
name: SubPathwayReaction
participant: Phenylacetic acid

SubPathwayInteraction113828
type: Interaction
name: SubPathway113828Reaction
name: SubPathwayReaction
participant: Phenylacetic acid

Reference/KEGG Compound C00601
type: UnificationXref
id: C00601
db: KEGG Compound

Reference/ChEBI CHEBI 16424
type: UnificationXref
id: CHEBI:16424
db: ChEBI

Reference/PubChem-compound 999
type: UnificationXref
id: 999
db: PubChem-compound

Reference/PubChem-compound 998
type: UnificationXref
id: 998
db: PubChem-compound

Reference/UniProt P46883
type: UnificationXref
id: P46883
db: UniProt

Reference/PathWhiz PW124606
type: UnificationXref
id: PW124606
db: PathWhiz

Phenylacetaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Phenylacetaldehyde

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

1.4.3.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007816 Periplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Periplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Periplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608 Periplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Periplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002680 Periplasm/Stoichiometry/1.0
right: Hydrogen peroxide
right: Ammonium
right: Phenylacetaldehyde
spontaneous: false
EC number: 1.4.3.21
left: Water
left: Oxygen
left: Phenylethylamine
name: Oxygen + Phenylethylamine + Water → Ammonium + Hydrogen peroxide + Phenylacetaldehyde
conversion direction: LEFT_TO_RIGHT

1.2.1.39
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002680 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000135 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Phenylacetic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.2.1.39
left: NAD
left: Phenylacetaldehyde
left: Water
name: NAD + Phenylacetaldehyde + Water → Hydrogen Ion + NADH + Phenylacetic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Metabolism and Physiological Effects of Phenylacetic Acid
type: Pathway
pathway order: PathwayTransport/2511539
pathway order: PathwayEnzymeReaction/2511535
pathway order: PathwayTransport/2467716
pathway order: PathwayEnzymeReaction/2511540
pathway order: PathwaySubPathway/113827
pathway order: PathwayTransport/2511543
pathway order: PathwaySubPathway/113828
pathway order: PathwaySubPathway/118434
pathway order: PathwayTransport/2511541
pathway order: PathwayTransport/2511536
pathway order: PathwayEnzymeReaction/2511538
pathway order: PathwayTransport/2511544
pathway component: Transport14539
pathway component: Reduced nitric oxide production, reduced protection against inflammation in vessel walls
pathway component: 1.4.3.21
pathway component: Transport14538
pathway component: ROS production and oxidative stress
pathway component: 1.2.1.39
pathway component: SubPathwayControl118434
pathway component: Transport14537
pathway component: Reaction218897
pathway component: Transport14536
pathway component: ReactionCatalysis208361
pathway component: Transport11273
pathway component: TransportCatalysis5354
pathway component: ReactionCatalysis5882
pathway component: ReactionCatalysis5881
pathway component: TransportCatalysis5352
pathway component: TransportCatalysis5353
pathway component: TransportCatalysis5350
pathway component: TransportCatalysis5351
xref: Reference/SMPDB SMP0123256
xref: Reference/PathWhiz PW124606
organism: Homo sapiens

Reaction218897
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007816/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Carbon dioxide
right: Phenylethylamine
spontaneous: false
left: Hydrogen Ion
left: L-Phenylalanine
name: Hydrogen Ion + L-Phenylalanine → Carbon dioxide + Phenylethylamine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000159
type: UnificationXref
id: HMDB0000159
db: HMDB

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Hydrogen peroxide
type: SmallMolecule
cellular location: Periplasm
entity reference: Hydrogen peroxide

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Reference/CAS 64-04-0
type: UnificationXref
id: 64-04-0
db: CAS

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Primary amine oxidase
type: ProteinReference
xref: Reference/UniProt P46883
organism: BiologicalState238

Reference/ChEBI CHEBI 17295
type: UnificationXref
id: CHEBI:17295
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/BioCyc PHE
type: UnificationXref
id: PHE
db: BioCyc

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Protein/6808 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Phenylacetaldehyde dehydrogenase
stoichiometric coefficient: 2.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

L-Phenylalanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6140
xref: Reference/HMDB HMDB0000159
xref: Reference/ChemSpider 5910
xref: Reference/ChEBI CHEBI 17295
xref: Reference/BioCyc PHE
xref: Reference/CAS 63-91-2
xref: Reference/KEGG Compound C00079
chemical formula: C9H11NO2
molecular weight: 165.07898
structure: ChemicalStructure/PW C000104

Compound/PW C000135 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylacetic acid
stoichiometric coefficient: 1.0

Reduced nitric oxide production, reduced protection against inflammation in vessel walls
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113827
pathway component: SubPathwayInteraction113827
name: SubPathway

ROS production and oxidative stress
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113828
pathway component: SubPathwayInteraction113828
name: SubPathway

Aromatic-L-amino-acid decarboxylase
type: Protein
entity reference: Aromatic-L-amino-acid decarboxylase

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Phenylacetic acid
type: SmallMolecule
entity reference: Phenylacetic acid
name: SubPathwayInput
name: SubPathwayActivator

Reference/HMDB HMDB0012275
type: UnificationXref
id: HMDB0012275
db: HMDB

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00079
type: UnificationXref
id: C00079
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Phenylacetaldehyde
type: SmallMolecule
cellular location: Periplasm
entity reference: Phenylacetaldehyde

Protein/6636 Periplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Primary amine oxidase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/UniProt Q9UM01
type: UnificationXref
id: Q9UM01
db: UniProt

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChemSpider 5910
type: UnificationXref
id: 5910
db: ChemSpider

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 30745
type: UnificationXref
id: CHEBI:30745
db: ChEBI

Primary amine oxidase
type: Protein
cellular location: Periplasm
entity reference: Primary amine oxidase

Water
type: SmallMolecule
cellular location: Periplasm
entity reference: Water

Reference/BioCyc PHENYLETHYLAMINE
type: UnificationXref
id: PHENYLETHYLAMINE
db: BioCyc

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

Phenylacetaldehyde dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Phenylacetaldehyde dehydrogenase

Reference/CAS 122-78-1
type: UnificationXref
id: 122-78-1
db: CAS

Reference/CAS 103-82-2
type: UnificationXref
id: 103-82-2
db: CAS

Phenylethylamine
type: SmallMolecule
cellular location: Periplasm
entity reference: Phenylethylamine

ChemicalStructure/PW C007816
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC=CC=C1

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Compound/PW C000135/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylacetic acid
stoichiometric coefficient: 1.0

Transport11273
type: Transport
participant stoichiometry: Compound/PW C000104/Stoichiometry/1.0
right: L-Phenylalanine
spontaneous: false
left: L-Phenylalanine
name: L-Phenylalanine (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Unknown
type: ProteinReference

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Transport14539
type: Transport
participant stoichiometry: Compound/PW C000135/Stoichiometry/1.0
right: Phenylacetic acid
spontaneous: false
left: Phenylacetic acid
name: Phenylacetic acid (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

L-Phenylalanine
type: SmallMolecule
entity reference: L-Phenylalanine

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Transport14538
type: Transport
participant stoichiometry: Compound/PW C000135/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000135 Cytosol/Stoichiometry/1.0
right: Phenylacetic acid
spontaneous: false
left: Phenylacetic acid
name: Phenylacetic acid (→) Transport: Escherichia coli (strain K12), Cytosol to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Transport14537
type: Transport
participant stoichiometry: Compound/PW C002680 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002680 Periplasm/Stoichiometry/1.0
right: Phenylacetaldehyde
spontaneous: false
left: Phenylacetaldehyde
name: Phenylacetaldehyde (→) Transport: Escherichia coli (strain K12), Periplasm to Escherichia coli (strain K12), Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14536
type: Transport
participant stoichiometry: Compound/PW C007816 Periplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007816/Stoichiometry/1.0
right: Phenylethylamine
spontaneous: false
left: Phenylethylamine
name: Phenylethylamine (→) Transport: Homo sapiens, Intestine to Escherichia coli, Periplasm
conversion direction: LEFT_TO_RIGHT

Compound/PW C007816/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenylethylamine
stoichiometric coefficient: 1.0

ReactionCatalysis208361
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: Reaction218897
control type: ACTIVATION