Carnitine O-acetyltransferase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Carnitine O-acetyltransferase

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PathWhiz PW002364
type: UnificationXref
id: PW002364
db: PathWhiz

ReactionCatalysis202879
type: Catalysis
controller: acetyl-CoA carboxylase
controlled: Reaction213291
control type: ACTIVATION

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/KEGG Compound C00318
type: UnificationXref
id: C00318
db: KEGG Compound

L-Palmitoylcarnitine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000222
xref: Reference/CAS 2364-67-2
xref: Reference/PubChem-compound 11953816
xref: Reference/ChEBI CHEBI 17490
xref: Reference/ChemSpider 10128117
xref: Reference/KEGG Compound C02990
xref: Reference/BioCyc CPD-419
chemical formula: C23H45NO4
molecular weight: 399.33487
structure: ChemicalStructure/PW C000147

Reference/UniProt P06213
type: UnificationXref
id: P06213
db: UniProt

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

TransportCatalysis2419
type: Catalysis
controller: Mitochondrial carnitine/acylcarnitine carrier protein
controlled: Transport11302
control type: ACTIVATION

TransportCatalysis2418
type: Catalysis
controller: Long-chain fatty acid transport protein 1
controlled: Transport11301
control type: ACTIVATION

Palmitic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Palmitic acid

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

direct_interaction
type: InteractionVocabulary

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Insulin Signalling
type: Pathway
xref: Reference/SMPDB SMP0000391
xref: Reference/PathWhiz PW000454
name: ActivatingSubPathway

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA

L-Carnitine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Carnitine

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/BioCyc CPD-419
type: UnificationXref
id: CPD-419
db: BioCyc

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

TransportCatalysis4721
type: Catalysis
controller: Solute carrier family 22 member 5
controlled: Transport13620
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Insulin
type: Protein
cellular location: Cell Membrane
entity reference: Insulin

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PathWhiz PW000173
type: UnificationXref
id: PW000173
db: PathWhiz

Reference/ChemSpider 4514331
type: UnificationXref
id: 4514331
db: ChemSpider

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: L-Carnitine

Reference/HMDB HMDB0002168
type: UnificationXref
id: HMDB0002168
db: HMDB

Reference/PubChem-compound 5359597
type: UnificationXref
id: 5359597
db: PubChem-compound

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Mitochondrial carnitine/acylcarnitine carrier protein
type: Protein
entity reference: Mitochondrial carnitine/acylcarnitine carrier protein

Solute carrier family 22 member 5
type: Protein
entity reference: Solute carrier family 22 member 5

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

L-Carnitine
type: SmallMoleculeReference
xref: Reference/BioCyc CARNITINE
xref: Reference/ChEBI CHEBI 16347
xref: Reference/PubChem-compound 10917
xref: Reference/CAS 541-15-1
xref: Reference/KEGG Compound C00318
xref: Reference/HMDB HMDB0000062
xref: Reference/ChemSpider 10455
chemical formula: C7H15NO3
molecular weight: 161.1052
structure: ChemicalStructure/PW C000044

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C000147 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Palmitoylcarnitine
stoichiometric coefficient: 1.0

4.1.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Acetyl-CoA
spontaneous: false
EC number: 4.1.1.9
left: Malonyl-CoA
name: Malonyl-CoA → Acetyl-CoA + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc PALMITYL-COA
type: UnificationXref
id: PALMITYL-COA
db: BioCyc

Reference/PathWhiz PW000165
type: UnificationXref
id: PW000165
db: PathWhiz

L-Acetylcarnitine
type: SmallMoleculeReference
xref: Reference/CAS 3040-38-8
xref: Reference/PubChem-compound 1
xref: Reference/ChemSpider 21243783
xref: Reference/HMDB HMDB0000201
xref: Reference/KEGG Compound C02571
xref: Reference/BioCyc (-)o-acetylcarnitine
xref: Reference/ChEBI CHEBI 73024
chemical formula: C9H17NO4
molecular weight: 203.11575
structure: ChemicalStructure/PW C000129

Malonyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Malonyl-CoA

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Superoxide
type: SmallMoleculeReference
xref: Reference/ChemSpider 4514331
xref: Reference/HMDB HMDB0002168
xref: Reference/CAS 11062-77-4
xref: Reference/PubChem-compound 5359597
xref: Reference/KEGG Compound C00704
xref: Reference/ChEBI CHEBI 18421
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001457

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

ReactionCatalysis290
type: Catalysis
controller: Carnitine O-palmitoyltransferase 2, mitochondrial
controlled: 2.3.1.21
control type: ACTIVATION

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C02990
type: UnificationXref
id: C02990
db: KEGG Compound

Compound/PW C000145 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Protein/5775 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 2.0

Protein/6172 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Biotin carboxyl carrier protein of acetyl-CoA carboxylase
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/6171 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
stoichiometric coefficient: 2.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/UniProt P0A9Q5
type: UnificationXref
id: P0A9Q5
db: UniProt

6.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: Palmitoyl-CoA
right: Pyrophosphate
spontaneous: false
EC number: 6.2.1.3
left: Adenosine triphosphate
left: Coenzyme A
left: Palmitic acid
name: Adenosine triphosphate + Coenzyme A + Palmitic acid → Adenosine monophosphate + Palmitoyl-CoA + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.3.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000147 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000147 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Palmitoylcarnitine
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.21
left: L-Carnitine
left: Palmitoyl-CoA
name: L-Carnitine + Palmitoyl-CoA ↔ Coenzyme A + L-Palmitoylcarnitine
conversion direction: REVERSIBLE

Insulin receptor
type: Protein
cellular location: Cell Membrane
entity reference: Insulin receptor

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Carnitine

ReactionCatalysis1101
type: Catalysis
controller: Carnitine O-acetyltransferase
controlled: 2.3.1.7
control type: ACTIVATION

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

ReactionCatalysis289
type: Catalysis
controller: Carnitine O-palmitoyltransferase 1
controlled: 2.3.1.21
control type: ACTIVATION

Reference/CAS 2364-67-2
type: UnificationXref
id: 2364-67-2
db: CAS

ReactionCatalysis961
type: Catalysis
controller: Malonyl-CoA decarboxylase, mitochondrial
controlled: 4.1.1.9
control type: ACTIVATION

ReactionCatalysis288
type: Catalysis
controller: Long-chain-fatty-acid--CoA ligase 1
controlled: 6.2.1.3
control type: ACTIVATION

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Compound/PW C000044 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA
name: SubPathwayOutput

Compound/PW C001031 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Interaction3511
type: MolecularInteraction
interaction type: direct_interaction
name: Malonyl-CoA inhibits Carnitine O-palmitoyltransferase 1
participant: Carnitine O-palmitoyltransferase 1
participant: Malonyl-CoA

Interaction369
type: MolecularInteraction
interaction type: direct_interaction
name: Insulin activates Insulin receptor
participant: Insulin
participant: Insulin receptor

Reference/ChEBI CHEBI 18421
type: UnificationXref
id: CHEBI:18421
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/CAS 3040-38-8
type: UnificationXref
id: 3040-38-8
db: CAS

Reference/HMDB HMDB0000201
type: UnificationXref
id: HMDB0000201
db: HMDB

Palmitic acid
type: SmallMolecule
entity reference: Palmitic acid

2.3.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000044 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000129 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
right: Coenzyme A
right: L-Acetylcarnitine
spontaneous: false
EC number: 2.3.1.7
left: Acetyl-CoA
left: L-Carnitine
name: Acetyl-CoA + L-Carnitine ↔ Coenzyme A + L-Acetylcarnitine
conversion direction: REVERSIBLE

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Palmitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 985
xref: Reference/KEGG Compound C00249
xref: Reference/ChemSpider 960
xref: Reference/ChEBI CHEBI 15756
xref: Reference/BioCyc CPD-8475
xref: Reference/CAS 57-10-3
xref: Reference/HMDB HMDB0000220
chemical formula: C16H32O2
molecular weight: 256.24023
structure: ChemicalStructure/PW C000145

Reference/SMPDB SMP0002296
type: UnificationXref
id: SMP0002296
db: SMPDB

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15525
type: UnificationXref
id: CHEBI:15525
db: ChEBI

Reference/CAS 541-15-1
type: UnificationXref
id: 541-15-1
db: CAS

ChemicalStructure/PW C000129
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

SubPathwayControl113858
type: Interaction
name: SubPathway113858Control
name: ActivatingSubPathwayControl
participant: Insulin Signalling
participant: Insulin receptor
participant: acetyl-CoA carboxylase

ChemicalStructure/PW C001457
type: ChemicalStructure
structure format: SMILES
structure data: [O][O-]

Carnitine O-acetyltransferase
type: ProteinReference
xref: Reference/UniProt P43155
organism: Homo sapiens

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Carnitine O-palmitoyltransferase 1, liver isoform
type: Protein
cellular location: Mitochondrial Intermembrane Space
entity reference: Carnitine O-palmitoyltransferase 1, liver isoform

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Carnitine O-palmitoyltransferase 2, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Carnitine O-palmitoyltransferase 2, mitochondrial

Mitochondrial Electron Transport Chain
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113971
pathway component: SubPathwayInteraction113971
xref: Reference/PathWhiz PW000165
xref: Reference/SMPDB SMP0000355
name: SubPathway

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00249
type: UnificationXref
id: C00249
db: KEGG Compound

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Coenzyme A

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0123289
type: UnificationXref
id: SMP0123289
db: SMPDB

Palmitoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Palmitoyl-CoA

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C000147 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Palmitoylcarnitine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/CAS 1763-10-6
type: UnificationXref
id: 1763-10-6
db: CAS

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
type: ProteinReference
xref: Reference/UniProt P0A9Q5
organism: Homo sapiens

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH
name: SubPathwayOutput
name: SubPathwayInput

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/HMDB HMDB0000222
type: UnificationXref
id: HMDB0000222
db: HMDB

Transport13620
type: Transport
participant stoichiometry: Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
right: L-Carnitine
spontaneous: false
left: L-Carnitine
name: L-Carnitine (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction113971
type: Interaction
name: SubPathway113971Reaction
name: SubPathwayReaction
participant: Superoxide
participant: NADH

Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113855
pathway component: SubPathwayInteraction113855
xref: Reference/PathWhiz PW000173
xref: Reference/SMPDB SMP0000482
name: SubPathway

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

ChemicalStructure/PW C000147
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

Reference/UniProt P23786
type: UnificationXref
id: P23786
db: UniProt

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

ChemicalStructure/PW C000145
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(O)=O

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

SubPathwayInteraction113855
type: Interaction
name: SubPathway113855Reaction
name: SubPathwayReaction
participant: Palmitoyl-CoA
participant: Acetyl-CoA

SubPathwayInteraction113857
type: Interaction
name: SubPathwayReaction
name: SubPathway113857Reaction
participant: Palmitic acid
participant: Palmitoyl-CoA

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Insulin receptor
type: Protein
cellular location: Cytosol
entity reference: Insulin receptor
name: SubPathwayActivator

Reference/HMDB HMDB0000220
type: UnificationXref
id: HMDB0000220
db: HMDB

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Protein/6136 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
stoichiometric coefficient: 2.0

Solute carrier family 22 member 5
type: ProteinReference
xref: Reference/UniProt O76082

Mitochondrial carnitine/acylcarnitine carrier protein
type: ProteinReference
xref: Reference/UniProt O43772

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/ChEBI CHEBI 73024
type: UnificationXref
id: CHEBI:73024
db: ChEBI

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Carnitine O-palmitoyltransferase 1, liver isoform
type: Protein
cellular location: Cytosol
entity reference: Carnitine O-palmitoyltransferase 1, liver isoform

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/UniProt P01308
type: UnificationXref
id: P01308
db: UniProt

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Reference/PubChem-compound 1
type: UnificationXref
id: 1
db: PubChem-compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Insulin
type: Complex
component stoichiometry: Protein/5775 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Insulin

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/BioCyc CARNITINE
type: UnificationXref
id: CARNITINE
db: BioCyc

carboxylated-biotinylated [BCCP dimer]
type: Protein
cellular location: Cytosol
entity reference: carboxylated-biotinylated [BCCP dimer]

Reference/KEGG Compound C00704
type: UnificationXref
id: C00704
db: KEGG Compound

Reference/ChEBI CHEBI 15756
type: UnificationXref
id: CHEBI:15756
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Palmitoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Palmitoyl-CoA

Protein/303 Cytosol/Stoichiometry/6.0
type: Stoichiometry
physical entity: Carnitine O-palmitoyltransferase 1, liver isoform
stoichiometric coefficient: 6.0

Transport11301
type: Transport
participant stoichiometry: Compound/PW C000145/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145 Extracellular Space/Stoichiometry/1.0
right: Palmitic acid
spontaneous: false
left: Palmitic acid
name: Palmitic acid (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell
conversion direction: LEFT_TO_RIGHT

Malonyl-CoA decarboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O95822
organism: Homo sapiens

Transport11302
type: Transport
participant stoichiometry: Compound/PW C000147 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000147 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Palmitoylcarnitine
spontaneous: false
left: L-Palmitoylcarnitine
name: L-Palmitoylcarnitine (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Liver, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O95822
type: UnificationXref
id: O95822
db: UniProt

L-Palmitoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Palmitoylcarnitine

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Palmitoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 15667
xref: Reference/ChemSpider 14902
xref: Reference/HMDB HMDB0001338
xref: Reference/ChEBI CHEBI 15525
xref: Reference/KEGG Compound C00154
xref: Reference/CAS 1763-10-6
xref: Reference/BioCyc PALMITYL-COA
chemical formula: C37H66N7O17P3S
molecular weight: 1005.34485
structure: ChemicalStructure/PW C001031

Reference/UniProt P43155
type: UnificationXref
id: P43155
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/KEGG Compound C02571
type: UnificationXref
id: C02571
db: KEGG Compound

Reference/UniProt O76082
type: UnificationXref
id: O76082
db: UniProt

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/ChEBI CHEBI 17490
type: UnificationXref
id: CHEBI:17490
db: ChEBI

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Palmitoyl-CoA
type: SmallMolecule
entity reference: Palmitoyl-CoA
name: SubPathwayInput

Reference/HMDB HMDB0001338
type: UnificationXref
id: HMDB0001338
db: HMDB

Reference/UniProt P33121
type: UnificationXref
id: P33121
db: UniProt

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/KEGG Compound C00154
type: UnificationXref
id: C00154
db: KEGG Compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Carnitine O-palmitoyltransferase 1, liver isoform
type: ProteinReference
xref: Reference/UniProt P50416
organism: Homo sapiens

Carnitine O-palmitoyltransferase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P23786
organism: BiologicalState6

Compound/PW C001031 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Long-chain-fatty-acid--CoA ligase 1
type: ProteinReference
xref: Reference/UniProt P33121
organism: Homo sapiens

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Biotin carboxyl carrier protein of acetyl-CoA carboxylase
type: ProteinReference
xref: Reference/UniProt P0ABD8
organism: Homo sapiens

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
type: ProteinReference
xref: Reference/UniProt P0ABD5
organism: Homo sapiens

Reference/UniProt Q6PCB7
type: UnificationXref
id: Q6PCB7
db: UniProt

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

TCA Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113968
pathway component: SubPathwayInteraction113968
xref: Reference/PathWhiz PW002364
xref: Reference/SMPDB SMP0002296
name: SubPathway

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Protein/6432 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Biotin carboxylase
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Protein/Generic249 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: carboxylated-biotinylated [BCCP dimer]
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/SMPDB SMP0000482
type: UnificationXref
id: SMP0000482
db: SMPDB

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000454
type: UnificationXref
id: PW000454
db: PathWhiz

Reference/BioCyc CPD-8475
type: UnificationXref
id: CPD-8475
db: BioCyc

a biotinylated [BCCP dimer]
type: Protein
cellular location: Cytosol
entity reference: a biotinylated [BCCP dimer]

L-Acetylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Acetylcarnitine

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Targets for the reduction of acylcarnitine content
type: Pathway
pathway order: PathwayEnzymeReaction/2467945
pathway order: PathwayEnzymeReaction/2467944
pathway order: PathwayInteraction/369
pathway order: PathwayTransport/2467949
pathway order: PathwaySubPathway/113855
pathway order: PathwayEnzymeReaction/2467957
pathway order: PathwayTransport/2467947
pathway order: PathwaySubPathway/113857
pathway order: PathwayEnzymeReaction/2467959
pathway order: PathwaySubPathway/113858
pathway order: PathwaySubPathway/113968
pathway order: PathwayTransport/2498829
pathway order: PathwayEnzymeReaction/2467952
pathway order: PathwayEnzymeReaction/2467943
pathway order: PathwayInteraction/3511
pathway order: PathwayEnzymeReaction/2498826
pathway order: PathwaySubPathway/113971
pathway component: ReactionCatalysis202879
pathway component: ReactionCatalysis290
pathway component: SubPathwayControl113858
pathway component: TransportCatalysis2419
pathway component: TransportCatalysis2418
pathway component: Reaction213291
pathway component: Reaction213292
pathway component: TCA Cycle
pathway component: 6.2.1.3
pathway component: 2.3.1.21
pathway component: Mitochondrial Electron Transport Chain
pathway component: ReactionCatalysis1101
pathway component: ReactionCatalysis289
pathway component: ReactionCatalysis961
pathway component: ReactionCatalysis288
pathway component: TransportCatalysis4721
pathway component: Interaction3511
pathway component: Interaction369
pathway component: Transport11301
pathway component: Transport11302
pathway component: Transport13620
pathway component: Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
pathway component: 2.3.1.7
pathway component: Activation of peroxisomal FA Ooxidation
pathway component: 4.1.1.9
xref: Reference/SMPDB SMP0123289
xref: Reference/PathWhiz PW124639
organism: Homo sapiens

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

ChemicalStructure/PW C001031
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 10917
type: UnificationXref
id: 10917
db: PubChem-compound

Compound/PW C000044 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/ChemSpider 10128117
type: UnificationXref
id: 10128117
db: ChemSpider

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Carnitine O-palmitoyltransferase 1
type: Complex
component stoichiometry: Protein/303 Mitochondrial Intermembrane Space/Stoichiometry/6.0
cellular location: Mitochondrial Intermembrane Space
component: Carnitine O-palmitoyltransferase 1, liver isoform

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 10455
type: UnificationXref
id: 10455
db: ChemSpider

Long-chain fatty acid transport protein 1
type: Protein
entity reference: Long-chain fatty acid transport protein 1

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Reference/UniProt P24182
type: UnificationXref
id: P24182
db: UniProt

Reference/ChemSpider 14902
type: UnificationXref
id: 14902
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Malonyl-CoA decarboxylase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Malonyl-CoA decarboxylase, mitochondrial

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Insulin
type: ProteinReference
xref: Reference/UniProt P01308
organism: Homo sapiens

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/CAS 11062-77-4
type: UnificationXref
id: 11062-77-4
db: CAS

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

SubPathwayInteraction113968
type: Interaction
name: SubPathway113968Reaction
name: SubPathwayReaction
participant: Acetyl-CoA
participant: NADH

Reference/CAS 57-10-3
type: UnificationXref
id: 57-10-3
db: CAS

Biotin carboxyl carrier protein of acetyl-CoA carboxylase
type: Protein
cellular location: Cytosol
entity reference: Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Reference/UniProt O43772
type: UnificationXref
id: O43772
db: UniProt

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Palmitoyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Palmitoyl-CoA
name: SubPathwayInput

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000044
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)C[C@H](O)CC([O-])=O

Reference/SMPDB SMP0000391
type: UnificationXref
id: SMP0000391
db: SMPDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Protein/Generic248 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: a biotinylated [BCCP dimer]
stoichiometric coefficient: 1.0

Compound/PW C000129 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

Palmitic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Palmitic acid
name: SubPathwayInput

Compound/PW C000145 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/BioCyc (-)o-acetylcarnitine
type: UnificationXref
id: (-)o-acetylcarnitine
db: BioCyc

Long-chain-fatty-acid--CoA ligase 1
type: Protein
cellular location: Cytosol
entity reference: Long-chain-fatty-acid--CoA ligase 1

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/PathWhiz PW124639
type: UnificationXref
id: PW124639
db: PathWhiz

Reference/UniProt P0ABD5
type: UnificationXref
id: P0ABD5
db: UniProt

Long-chain fatty acid transport protein 1
type: ProteinReference
xref: Reference/UniProt Q6PCB7

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/UniProt P50416
type: UnificationXref
id: P50416
db: UniProt

Reference/UniProt P0ABD8
type: UnificationXref
id: P0ABD8
db: UniProt

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Compound/PW C000145/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

BiologicalState6
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 16347
type: UnificationXref
id: CHEBI:16347
db: ChEBI

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

a biotinylated [BCCP dimer]
type: ProteinReference
organism: Homo sapiens

carboxylated-biotinylated [BCCP dimer]
type: ProteinReference
organism: Homo sapiens

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Superoxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Superoxide
name: SubPathwayOutput

Reference/ChemSpider 960
type: UnificationXref
id: 960
db: ChemSpider

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/HMDB HMDB0000062
type: UnificationXref
id: HMDB0000062
db: HMDB

L-Palmitoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: L-Palmitoylcarnitine

Reference/PubChem-compound 985
type: UnificationXref
id: 985
db: PubChem-compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
type: Protein
cellular location: Cytosol
entity reference: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

L-Carnitine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Carnitine

Insulin receptor
type: ProteinReference
xref: Reference/UniProt P06213
organism: Homo sapiens

Protein/303 Mitochondrial Intermembrane Space/Stoichiometry/6.0
type: Stoichiometry
physical entity: Carnitine O-palmitoyltransferase 1, liver isoform
stoichiometric coefficient: 6.0

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Compound/PW C001099 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChemSpider 21243783
type: UnificationXref
id: 21243783
db: ChemSpider

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reaction213291
type: BiochemicalReaction
participant stoichiometry: Protein/Generic248 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic249 Cytosol/Stoichiometry/1.0
right: Phosphate
right: carboxylated-biotinylated [BCCP dimer]
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
left: Adenosine triphosphate
left: a biotinylated [BCCP dimer]
left: Hydrogen carbonate
name: Adenosine triphosphate + Hydrogen carbonate + a biotinylated [BCCP dimer] → Adenosine diphosphate + Hydrogen Ion + Phosphate + carboxylated-biotinylated [BCCP dimer]
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reaction213292
type: BiochemicalReaction
participant stoichiometry: Protein/Generic248 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic249 Cytosol/Stoichiometry/1.0
right: carboxylated-biotinylated [BCCP dimer]
right: Adenosine triphosphate
right: Acetyl-CoA
right: Water
spontaneous: false
left: Phosphate
left: Adenosine diphosphate
left: Malonyl-CoA
left: Hydrogen Ion
left: a biotinylated [BCCP dimer]
name: Adenosine diphosphate + Hydrogen Ion + Malonyl-CoA + Phosphate + a biotinylated [BCCP dimer] ← Acetyl-CoA + Adenosine triphosphate + Water + carboxylated-biotinylated [BCCP dimer]
conversion direction: RIGHT_TO_LEFT

Compound/PW C000911 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

acetyl-CoA carboxylase
type: Complex
component stoichiometry: Protein/6171 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/6136 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/6432 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/6172 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
component: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
component: Biotin carboxylase
component: Biotin carboxyl carrier protein of acetyl-CoA carboxylase
name: SubPathwayActivation

Reference/PubChem-compound 15667
type: UnificationXref
id: 15667
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Biotin carboxylase
type: Protein
cellular location: Cytosol
entity reference: Biotin carboxylase

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Biotin carboxylase
type: ProteinReference
xref: Reference/UniProt P24182
organism: Homo sapiens

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Carnitine O-palmitoyltransferase 1
type: Complex
component stoichiometry: Protein/303 Cytosol/Stoichiometry/6.0
cellular location: Cytosol
component: Carnitine O-palmitoyltransferase 1, liver isoform

Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA
name: SubPathwayInput

Reference/PubChem-compound 11953816
type: UnificationXref
id: 11953816
db: PubChem-compound

Activation of peroxisomal FA Ooxidation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113857
pathway component: SubPathwayInteraction113857
name: SubPathway

Reference/SMPDB SMP0000355
type: UnificationXref
id: SMP0000355
db: SMPDB

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB