Reference/PathWhiz PW002364
type: UnificationXref
id: PW002364
db: PathWhiz

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/KEGG Compound C00318
type: UnificationXref
id: C00318
db: KEGG Compound

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
type: SmallMoleculeReference
chemical formula: C37H58N7O19P3S
molecular weight: 1029.2721
structure: ChemicalStructure/PW C111568

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
type: SmallMoleculeReference
chemical formula: C16H24O4
molecular weight: 280.16745
structure: ChemicalStructure/PW C111567

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0241502
chemical formula: C23H43NO7
molecular weight: 445.30396
structure: ChemicalStructure/PW C111566

TransportCatalysis2419
type: Catalysis
controller: Mitochondrial carnitine/acylcarnitine carrier protein
controlled: Transport13303
control type: ACTIVATION

TransportCatalysis2418
type: Catalysis
controller: Long-chain fatty acid transport protein 1
controlled: Transport13302
control type: ACTIVATION

direct_interaction
type: InteractionVocabulary

L-Carnitine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Carnitine

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Acetyl-CoA carboxylase 1
type: Protein
entity reference: Acetyl-CoA carboxylase 1

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

TransportCatalysis2422
type: Catalysis
controller: Solute carrier family 22 member 5
controlled: Transport11315
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Transport13303
type: Transport
participant stoichiometry: Compound/PW C111566 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111566 Mitochondrial Matrix/Stoichiometry/1.0
right: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
spontaneous: false
left: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
name: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Liver, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Transport13302
type: Transport
participant stoichiometry: Compound/PW C111567 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111567/Stoichiometry/1.0
right: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
spontaneous: false
left: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
name: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW000173
type: UnificationXref
id: PW000173
db: PathWhiz

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Mitochondrial carnitine/acylcarnitine carrier protein
type: Protein
entity reference: Mitochondrial carnitine/acylcarnitine carrier protein

Solute carrier family 22 member 5
type: Protein
entity reference: Solute carrier family 22 member 5

L-Carnitine
type: SmallMolecule
entity reference: L-Carnitine

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
name: SubPathwayInput

Reaction1248
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
right: Malonyl-CoA
spontaneous: false
left: Acetyl-CoA
name: Acetyl-CoA → Malonyl-CoA
conversion direction: LEFT_TO_RIGHT

L-Carnitine
type: SmallMoleculeReference
xref: Reference/BioCyc CARNITINE
xref: Reference/ChEBI CHEBI 16347
xref: Reference/PubChem-compound 10917
xref: Reference/CAS 541-15-1
xref: Reference/KEGG Compound C00318
xref: Reference/HMDB HMDB0000062
xref: Reference/ChemSpider 10455
chemical formula: C7H15NO3
molecular weight: 161.1052
structure: ChemicalStructure/PW C000044

4.1.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
right: Carbon dioxide
right: Acetyl-CoA
spontaneous: false
EC number: 4.1.1.9
left: Malonyl-CoA
name: Malonyl-CoA → Acetyl-CoA + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

L-Acetylcarnitine
type: SmallMoleculeReference
xref: Reference/CAS 3040-38-8
xref: Reference/PubChem-compound 1
xref: Reference/ChemSpider 21243783
xref: Reference/HMDB HMDB0000201
xref: Reference/KEGG Compound C02571
xref: Reference/BioCyc (-)o-acetylcarnitine
xref: Reference/ChEBI CHEBI 73024
chemical formula: C9H17NO4
molecular weight: 203.11575
structure: ChemicalStructure/PW C000129

6.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111567/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111568/Stoichiometry/1.0
right: Adenosine monophosphate
right: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
right: Pyrophosphate
spontaneous: false
EC number: 6.2.1.3
left: Coenzyme A
left: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
left: Adenosine triphosphate
name: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid + Adenosine triphosphate + Coenzyme A → (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA + Adenosine monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

2.3.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111566/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111568/Stoichiometry/1.0
right: Coenzyme A
right: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
spontaneous: false
EC number: 2.3.1.21
left: L-Carnitine
left: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
name: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA + L-Carnitine ↔ (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine + Coenzyme A
conversion direction: REVERSIBLE

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reaction217049
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111566/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044/Stoichiometry/1.0
participant stoichiometry: Compound/PW C111568/Stoichiometry/1.0
right: L-Carnitine
right: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
spontaneous: false
left: Coenzyme A
left: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
name: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine + Coenzyme A → (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA + L-Carnitine
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/PathWhiz PW125750
type: UnificationXref
id: PW125750
db: PathWhiz

L-Carnitine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Carnitine

ReactionCatalysis962
type: Catalysis
controller: Acetyl-CoA carboxylase 1
controlled: Reaction1248
control type: ACTIVATION

ReactionCatalysis1101
type: Catalysis
controller: Carnitine O-acetyltransferase
controlled: 2.3.1.7
control type: ACTIVATION

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

ReactionCatalysis289
type: Catalysis
controller: Carnitine O-palmitoyltransferase 1
controlled: 2.3.1.21
control type: ACTIVATION

ReactionCatalysis961
type: Catalysis
controller: Malonyl-CoA decarboxylase, mitochondrial
controlled: 4.1.1.9
control type: ACTIVATION

ReactionCatalysis288
type: Catalysis
controller: Long-chain-fatty-acid--CoA ligase 1
controlled: 6.2.1.3
control type: ACTIVATION

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine

Interaction3511
type: MolecularInteraction
interaction type: direct_interaction
name: Malonyl-CoA inhibits Carnitine O-palmitoyltransferase 1
participant: Carnitine O-palmitoyltransferase 1
participant: Malonyl-CoA

Compound/PW C000044 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/CAS 3040-38-8
type: UnificationXref
id: 3040-38-8
db: CAS

Reference/HMDB HMDB0000201
type: UnificationXref
id: HMDB0000201
db: HMDB

2.3.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000129/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044/Stoichiometry/1.0
right: Coenzyme A
right: L-Acetylcarnitine
spontaneous: false
EC number: 2.3.1.7
left: L-Carnitine
left: Acetyl-CoA
name: Acetyl-CoA + L-Carnitine ↔ Coenzyme A + L-Acetylcarnitine
conversion direction: REVERSIBLE

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C000129/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

Compound/PW C111566 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0002296
type: UnificationXref
id: SMP0002296
db: SMPDB

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/CAS 541-15-1
type: UnificationXref
id: 541-15-1
db: CAS

ChemicalStructure/PW C000129
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Carnitine O-acetyltransferase
type: ProteinReference
xref: Reference/UniProt P43155

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Long-chain-fatty-acid--CoA ligase 1
type: Protein
entity reference: Long-chain-fatty-acid--CoA ligase 1

Carnitine O-palmitoyltransferase 1, liver isoform
type: Protein
entity reference: Carnitine O-palmitoyltransferase 1, liver isoform

Carnitine O-palmitoyltransferase 2, mitochondrial
type: Protein
entity reference: Carnitine O-palmitoyltransferase 2, mitochondrial

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/UniProt Q13085
type: UnificationXref
id: Q13085
db: UniProt

Compound/PW C111566/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
stoichiometric coefficient: 1.0

Carnitine O-palmitoyltransferase 1
type: Complex
component stoichiometry: Protein/303/Stoichiometry/6.0
component: Carnitine O-palmitoyltransferase 1, liver isoform

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C111566
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CC(CC([O-])=O)OC(=O)CCCCCC(O)CCCCCCCCC(O)=O

Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116089
pathway component: SubPathwayInteraction116089
xref: Reference/PathWhiz PW000173
xref: Reference/SMPDB SMP0000482
name: SubPathway

Reference/UniProt P23786
type: UnificationXref
id: P23786
db: UniProt

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Carnitine O-acetyltransferase
type: Protein
entity reference: Carnitine O-acetyltransferase

Solute carrier family 22 member 5
type: ProteinReference
xref: Reference/UniProt O76082

Transport11315
type: Transport
participant stoichiometry: Compound/PW C000044 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
right: L-Carnitine
spontaneous: false
left: L-Carnitine
name: L-Carnitine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Mitochondrial carnitine/acylcarnitine carrier protein
type: ProteinReference
xref: Reference/UniProt O43772

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/ChEBI CHEBI 73024
type: UnificationXref
id: CHEBI:73024
db: ChEBI

ChemicalStructure/PW C111567
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCCC\C=C/CC\C=C/CC\C=C/C(O)=O

ChemicalStructure/PW C111568
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/PubChem-compound 1
type: UnificationXref
id: 1
db: PubChem-compound

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Malonyl-CoA decarboxylase, mitochondrial
type: Protein
entity reference: Malonyl-CoA decarboxylase, mitochondrial

Reference/BioCyc CARNITINE
type: UnificationXref
id: CARNITINE
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Malonyl-CoA decarboxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O95822

Reference/UniProt O95822
type: UnificationXref
id: O95822
db: UniProt

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/UniProt P43155
type: UnificationXref
id: P43155
db: UniProt

Compound/PW C111566 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02571
type: UnificationXref
id: C02571
db: KEGG Compound

Reference/UniProt O76082
type: UnificationXref
id: O76082
db: UniProt

Reference/HMDB HMDB0241502
type: UnificationXref
id: HMDB0241502
db: HMDB

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C000911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt P33121
type: UnificationXref
id: P33121
db: UniProt

Carnitine O-palmitoyltransferase 1, liver isoform
type: ProteinReference
xref: Reference/UniProt P50416

Protein/303/Stoichiometry/6.0
type: Stoichiometry
physical entity: Carnitine O-palmitoyltransferase 1, liver isoform
stoichiometric coefficient: 6.0

Carnitine O-palmitoyltransferase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P23786

Long-chain-fatty-acid--CoA ligase 1
type: ProteinReference
xref: Reference/UniProt P33121

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/UniProt Q6PCB7
type: UnificationXref
id: Q6PCB7
db: UniProt

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

TCA Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116088
pathway component: SubPathwayInteraction116088
xref: Reference/PathWhiz PW002364
xref: Reference/SMPDB SMP0002296
name: SubPathway

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/SMPDB SMP0000482
type: UnificationXref
id: SMP0000482
db: SMPDB

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/SMPDB SMP0124294
type: UnificationXref
id: SMP0124294
db: SMPDB

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10917
type: UnificationXref
id: 10917
db: PubChem-compound

Reference/ChemSpider 10455
type: UnificationXref
id: 10455
db: ChemSpider

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Long-chain fatty acid transport protein 1
type: Protein
entity reference: Long-chain fatty acid transport protein 1

Acetyl-CoA carboxylase 1
type: ProteinReference
xref: Reference/UniProt Q13085

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ReactionCatalysis203665
type: Catalysis
controller: Carnitine O-palmitoyltransferase 2, mitochondrial
controlled: Reaction217049
control type: ACTIVATION

Compound/PW C111567/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
stoichiometric coefficient: 1.0

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/UniProt O43772
type: UnificationXref
id: O43772
db: UniProt

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C111567 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

ChemicalStructure/PW C000044
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)C[C@H](O)CC([O-])=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/BioCyc (-)o-acetylcarnitine
type: UnificationXref
id: (-)o-acetylcarnitine
db: BioCyc

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Long-chain fatty acid transport protein 1
type: ProteinReference
xref: Reference/UniProt Q6PCB7

Reference/UniProt P50416
type: UnificationXref
id: P50416
db: UniProt

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 16347
type: UnificationXref
id: CHEBI:16347
db: ChEBI

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Acylcarnitine (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
type: Pathway
pathway order: PathwayEnzymeReaction/2494849
pathway order: PathwayTransport/2494855
pathway order: PathwaySubPathway/116088
pathway order: PathwayTransport/2494856
pathway order: PathwayTransport/2494857
pathway order: PathwayInteraction/3511
pathway order: PathwayEnzymeReaction/2494852
pathway order: PathwayEnzymeReaction/2494853
pathway order: PathwayEnzymeReaction/2494850
pathway order: PathwaySubPathway/116089
pathway order: PathwayEnzymeReaction/2494851
pathway order: PathwayEnzymeReaction/2494854
pathway component: ReactionCatalysis289
pathway component: ReactionCatalysis961
pathway component: ReactionCatalysis288
pathway component: TransportCatalysis2422
pathway component: 6.2.1.3
pathway component: ReactionCatalysis203665
pathway component: Transport11315
pathway component: 2.3.1.21
pathway component: Interaction3511
pathway component: Transport13303
pathway component: Transport13302
pathway component: Reaction217049
pathway component: TransportCatalysis2419
pathway component: TransportCatalysis2418
pathway component: Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
pathway component: 2.3.1.7
pathway component: Reaction1248
pathway component: TCA Cycle
pathway component: 4.1.1.9
pathway component: ReactionCatalysis962
pathway component: ReactionCatalysis1101
xref: Reference/PathWhiz PW125750
xref: Reference/SMPDB SMP0124294
organism: Homo sapiens

Compound/PW C000044/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

L-Acetylcarnitine
type: SmallMolecule
entity reference: L-Acetylcarnitine

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/HMDB HMDB0000062
type: UnificationXref
id: HMDB0000062
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

SubPathwayInteraction116089
type: Interaction
name: SubPathway116089Reaction
name: SubPathwayReaction
participant: Acetyl-CoA
participant: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA

Malonyl-CoA
type: SmallMolecule
entity reference: Malonyl-CoA

SubPathwayInteraction116088
type: Interaction
name: SubPathway116088Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/ChemSpider 21243783
type: UnificationXref
id: 21243783
db: ChemSpider

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
type: SmallMolecule
entity reference: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid
type: SmallMolecule
entity reference: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioic acid

(2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine
type: SmallMolecule
entity reference: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioylcarnitine

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA
name: SubPathwayOutput
name: SubPathwayInput

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Compound/PW C111568/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2Z,6Z,10Z)-hexadeca-2,6,10-trienedioyl-CoA
stoichiometric coefficient: 1.0