PW002364
PathWhiz
C23H38N7O17P3S
Acetyl-CoA
809.1258
C00318
KEGG Compound
TransportCatalysis2419
ACTIVATION
TransportCatalysis2418
ACTIVATION
direct_interaction
L-Carnitine
C10H14N5O7P
Adenosine monophosphate
347.06308
Pyrophosphate
Acetyl-CoA carboxylase 1
CHEBI:16027
ChEBI
TransportCatalysis2422
ACTIVATION
HMDB0000538
HMDB
ATP
BioCyc
HMDB0241635
HMDB
PW000173
PathWhiz
1.0
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoyl-CoA
SubPathwayInput
6816
PubChem-compound
Mitochondrial carnitine/acylcarnitine carrier protein
Solute carrier family 22 member 5
L-Carnitine
559142
ChemSpider
Reaction1248
false
Acetyl-CoA → Malonyl-CoA
LEFT_TO_RIGHT
C7H15NO3
L-Carnitine
161.1052
4.1.1.9
false
4.1.1.9
Malonyl-CoA → Acetyl-CoA + Carbon dioxide
LEFT_TO_RIGHT
C9H17NO4
L-Acetylcarnitine
203.11575
1.0
5742
ChemSpider
GO:0005829
GENE ONTOLOGY
Adenosine monophosphate
274
ChemSpider
1.0
L-Carnitine
ReactionCatalysis962
ACTIVATION
ReactionCatalysis1101
ACTIVATION
5858
ChemSpider
ReactionCatalysis289
ACTIVATION
ReactionCatalysis961
ACTIVATION
ReactionCatalysis288
ACTIVATION
Acetyl-CoA
Interaction3511
Malonyl-CoA inhibits Carnitine O-palmitoyltransferase 1
1.0
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
3040-38-8
CAS
HMDB0000201
HMDB
2.3.1.7
false
2.3.1.7
Acetyl-CoA + L-Carnitine ↔ Coenzyme A + L-Acetylcarnitine
REVERSIBLE
PW125883
PathWhiz
PPI
BioCyc
1.0
SMP0002296
SMPDB
1.0
541-15-1
CAS
SMILES
CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C
Cytosol
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoyl-CoA
(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid
Carnitine O-acetyltransferase
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine
Adenosine triphosphate
HMDB0001423
HMDB
124-38-9
CAS
Long-chain-fatty-acid--CoA ligase 1
Carnitine O-palmitoyltransferase 1, liver isoform
Carnitine O-palmitoyltransferase 2, mitochondrial
CHEBI:15531
ChEBI
Q13085
UniProt
Carnitine O-palmitoyltransferase 1
CHEBI:18361
ChEBI
C00002
KEGG Compound
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
SubPathway
P23786
UniProt
GO:0005758
GENE ONTOLOGY
GO:0005759
GENE ONTOLOGY
1.0
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine
(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid
Acylcarnitine (9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine
Carnitine O-acetyltransferase
Solute carrier family 22 member 5
Transport11315
false
L-Carnitine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cytosol
LEFT_TO_RIGHT
C00011
KEGG Compound
SMILES
O=C=O
Mitochondrial carnitine/acylcarnitine carrier protein
C00010
KEGG Compound
CHEBI:73024
ChEBI
C00013
KEGG Compound
Extracellular Space
H4O7P2
Pyrophosphate
177.94322
1
PubChem-compound
5957
PubChem-compound
HMDB0001206
HMDB
1.0
Malonyl-CoA decarboxylase, mitochondrial
CARNITINE
BioCyc
C45H72N7O17P3S
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoyl-CoA
1107.3918
C24H38O2
(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid
358.28717
56-65-5
CAS
C31H49NO4
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine
499.36615
C00020
KEGG Compound
SubPathwayInteraction116354
SubPathwayReaction
SubPathway116354Reaction
Malonyl-CoA decarboxylase, mitochondrial
SubPathwayInteraction116355
SubPathwayReaction
SubPathway116355Reaction
O95822
UniProt
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
C00024
KEGG Compound
P43155
UniProt
C02571
KEGG Compound
O76082
UniProt
GO:0005615
GENE ONTOLOGY
1.0
P33121
UniProt
Carnitine O-palmitoyltransferase 1, liver isoform
6.0
Carnitine O-palmitoyltransferase 2, mitochondrial
Long-chain-fatty-acid--CoA ligase 1
CHEBI:1146900
ChEBI
AMP
BioCyc
Q6PCB7
UniProt
Mitochondrial Matrix
TCA Cycle
SubPathway
HMDB0000250
HMDB
SMILES
OP(O)(=O)OP(O)(O)=O
14000-31-8
CAS
SMP0000482
SMPDB
CO-A
BioCyc
72-89-9
CAS
1.0
Coenzyme A
C21H36N7O16P3S
Coenzyme A
767.11523
1.0
10917
PubChem-compound
10455
ChemSpider
10213
ChemSpider
Long-chain fatty acid transport protein 1
Acetyl-CoA carboxylase 1
1.0
CHEBI:15422
ChEBI
6557
ChemSpider
Homo sapiens
ReactionCatalysis203665
ACTIVATION
524-14-1
CAS
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
2.3.1.21
false
2.3.1.21
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoyl-CoA + L-Carnitine ↔ (9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine + Coenzyme A
REVERSIBLE
Reaction217448
false
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine + Coenzyme A → (9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoyl-CoA + L-Carnitine
LEFT_TO_RIGHT
6.2.1.3
false
6.2.1.3
(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid + Adenosine triphosphate + Coenzyme A → (9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoyl-CoA + Adenosine monophosphate + Pyrophosphate
LEFT_TO_RIGHT
61-19-8
CAS
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
1.0
O43772
UniProt
C10H16N5O13P3
Adenosine triphosphate
506.99576
1.0
CHEBI:16526
ChEBI
SMILES
C[N+](C)(C)C[C@H](O)CC([O-])=O
HMDB0000045
HMDB
9606
TAXONOMY
392413
ChemSpider
(-)o-acetylcarnitine
BioCyc
CO2
Carbon dioxide
43.98983
Long-chain fatty acid transport protein 1
P50416
UniProt
C00083
KEGG Compound
SMP0124427
SMPDB
Mitochondrial Intermembrane Space
C24H38N7O19P3S
Malonyl-CoA
853.1156
CHEBI:16347
ChEBI
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
SMILES
CCC=CCC=CCC=CCC=CCC=CCCCCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
SMILES
CCC=CCC=CCC=CCC=CCC=CC=CCCCCCC(=O)OC(CC([O-])=O)C[N+](C)(C)C
L-Acetylcarnitine
SMILES
CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O
280
PubChem-compound
HMDB0000062
HMDB
644102
PubChem-compound
444493
PubChem-compound
6083
PubChem-compound
Malonyl-CoA
10663
PubChem-compound
21243783
ChemSpider
ACETYL-COA
BioCyc
1.0
Carbon dioxide
HMDB0001967
HMDB
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine
CHEBI:15351
ChEBI
Transport13569
false
(9Z,12Z,15Z,18Z,21Z)-Tetracosa-9,12,15,18,21-pentaenoylcarnitine (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Liver, Mitochondrial Matrix
LEFT_TO_RIGHT
Transport13568
false
(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell
LEFT_TO_RIGHT
Acetyl-CoA
SubPathwayOutput
SubPathwayInput
1.0
85-61-0
CAS
MALONYL-COA
BioCyc
HMDB0001175
HMDB