4-Hydroxyifosfamide → 4-Ketoifosfamide
Hydrogen Ion + Ifosfamide + NADPH + Oxygen → 4-Hydroxyifosfamide + NADP + Water
Aldehyde dehydrogenase, dimeric NADP-preferring
Isophosphamide mustard (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
4-Hydroxyifosfamide ↔ Aldoifosfamide
Aldoifosfamide (→) Transport: Homo sapiens, Liver, Cell, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel, Cell, Extracellular Space
Aldoifosfamide (→) Transport: Homo sapiens, Blood Vessel, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
Aldoifosfamide + NAD + Water → Carboxyifosfamide + Hydrogen Ion + NADH
Acrolein + NAD + Water → Acrylic acid + Hydrogen Ion + NADH
Ifosfamide Alkylating Agent Action Pathway
Aldoifosfamide → Acrolein + Isophosphamide mustard